Catherine E. Costello, PhD
William Fairfield Warren Distinguished Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

PhD, Georgetown University
MS, Georgetown University
AB, Emmanuel College



Catherine Costello came to Boston University in 1994. That year she established the Center for Biomedical Mass Spectrometry, which has become an internationally recognized research center. She holds her primary appointment in the MED Biochemistry Department, with secondary appointments in the Department of Physiology & Biophysics and the Department of Chemistry. Her research, which focuses on determining the structures and functions of biologically important polymers, has revolutionized an important area of biochemistry by providing insights into the structures of molecules responsible for human disease. She is the author or co-author of more than 300 scientific papers, serves on a number of editorial boards of major journals, and has received numerous awards and honors, including the 2010 Field and Franklin Award from the American Chemical Society, one of the highest honors in her field.

Professor
Boston University Chobanian & Avedisian School of Medicine
Chemistry


Research Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics


Director
Boston University Chobanian & Avedisian School of Medicine
Center for Biomedical Mass Spectrometry


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Amyloidosis Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Mass Spectrometry analyses, matrix-assisted laser desorption/ionization and electrospray ionization tandem analyses
05/01/2023 - 05/01/2025 (PI)
Nutricia Research B.V


Cellular and humoral immunity in Lyme arthritis
01/08/2019 - 12/31/2023 (Subcontract PI)
Massachusetts General Hospital NIH NIAID
5R01AI144365-05

Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine
08/01/2019 - 12/31/2022 (PI)
NIH/National Institute of General Medical Sciences
5R24GM134210-03

Mass Spectrometry based Characterization of (a) O-glycan GAG (b) Enzymatic reaction on physiologically relevant Glycans and (c) Glycovariants and Charge variants of Biologics
04/01/2021 - 08/31/2022 (PI)
Takeda Pharmaceuticals North America, Inc.


Mass Spectrometry analyses, matrix-assisted laser desorption/ionization and electrospray ionization tandem analyses
12/01/2018 - 12/31/2021 (PI)
Nutricia Research B.V


Investigating PCR Reagent Quality and Its Impact on SARS-CoV-2 Assay Accuracy and Precision
06/01/2021 - 10/31/2021 (PI)
Waters Technologies Corporation


IPA Agreement for Juan Wei
04/05/2019 - 09/27/2019 (PI)
Department of Veterans Administration, Bedford


MASS SPECTROMETRY RESOURCE FOR BIOLOGY AND MEDICINE
06/01/2016 - 05/31/2019 (PI)
NIH/National Institute of General Medical Sciences
4P41GM104603-20

A Thermo-Fisher Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer System
03/06/2018 - 03/05/2019 (PI)
NIH/Office of the Director
1S10OD021728-01A1

A Thermo-Fisher Scientific Q-Exactive HF Mass Spectrometry System
05/01/2016 - 04/30/2017 (Key Person)
PI: Joseph Zaia, PhD
NIH/Office of the Director
1S10OD021651-01

Showing 10 of 24 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2021 Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine 5R24GM134210-03
2020 Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine 5R24GM134210-02
2019 Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine 1R24GM134210-01
2018 A Thermo-Fisher Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer System 1S10OD021728-01A1 2
2017 Mass Spectrometry Resource for Biology and Medicine 3P41GM104603-20S1 148
2016 Mass Spectrometry Resource for Biology and Medicine 4P41GM104603-20 148
2015 Mass Spectrometry Resource for Biology and Medicine 5P41GM104603-19 148
2014 Mass Spectrometry Resource for Biology and Medicine 5P41GM104603-18 148
2013 TAS::75 0872::TAS PROTEOMIC CENTERS: MODIFICATION OF CARDIOVASCULAR PROTEINS BY 268201000031C-5-0-1
2013 Mass Spectrometry Resource for Biology and Medicine 5P41GM104603-17 148
Showing 10 of 417 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. van der Wel H, Garcia AM, Gas-Pascual E, Willis MM, Kim HW, Bandini G, Gaye MM, Costello CE, Samuelson J, West CM. Spindly is a nucleocytosolic O-fucosyltransferase in Dictyostelium and related proteins are widespread in protists and bacteria. Glycobiology. 2023 Apr 19; 33(3):225-244.View Related Profiles. PMID: 36250576; PMCID: PMC10114647; DOI: 10.1093/glycob/cwac071;
     
  2. Sanes JT, Costello CE, Steere AC. Heightened Proinflammatory Glycosylation of Borrelia burgdorferi IgG Antibodies in Synovial Fluid in Patients With Antibiotic-Refractory Lyme Arthritis. Arthritis Rheumatol. 2023 Jan 30. PMID: 36716113
     
  3. Zhu G, Yan W, Wang X, Cheng R, Naowarojna N, Wang K, Wang J, Song H, Wang Y, Liu H, Xia X, Costello CE, Liu X, Zhang L, Liu P. Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues. JACS Au. 2022 Jul 25; 2(7):1686-1698. PMID: 35911443; PMCID: PMC9326825; DOI: 10.1021/jacsau.2c00248;
     
  4. Gaye MM, Ward CM, Piasecki AJ, Stahl VL, Karagianni A, Costello CE, Ravid K. Characterization of Glycoproteoforms of Integrins a2 and ß1 in Megakaryocytes in the Occurrence of JAK2V617F Mutation-Induced Primary Myelofibrosis. Mol Cell Proteomics. 2022 Apr; 21(4):100213.View Related Profiles. PMID: 35182768; PMCID: PMC8968581; DOI: 10.1016/j.mcpro.2022.100213;
     
  5. Chen Z, Wei J, Tang Y, Lin C, Costello CE, Hong P. GlycoDeNovo2: An Improved MS/MS-Based De Novo Glycan Topology Reconstruction Algorithm. J Am Soc Mass Spectrom. 2022 Mar 02; 33(3):436-445. PMID: 35157458; PMCID: PMC9149727; DOI: 10.1021/jasms.1c00288;
     
  6. Amraei R, Xia C, Olejnik J, White MR, Napoleon MA, Lotfollahzadeh S, Hauser BM, Schmidt AG, Chitalia V, Mühlberger E, Costello CE, Rahimi N. Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells. Proc Natl Acad Sci U S A. 2022 02 08; 119(6).View Related Profiles. PMID: 35078919; PMCID: PMC8833221; DOI: 10.1073/pnas.2113874119;
     
  7. Pianta A, Chiumento G, Ramsden K, Wang Q, Strle K, Arvikar S, Costello CE, Steere AC. Identification of Novel, Immunogenic HLA-DR-Presented Prevotella copri Peptides in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2021 12; 73(12):2200-2205. PMID: 34042327; PMCID: PMC8626540; DOI: 10.1002/art.41807;
     
  8. Liu L, Veis J, Reiter W, Motari E, Costello CE, Samuelson JC, Ammerer G, Levin DE. Regulation of Pkc1 Hyper-Phosphorylation by Genotoxic Stress. J Fungi (Basel). 2021 Oct 17; 7(10).View Related Profiles. PMID: 34682295; PMCID: PMC8541566; DOI: 10.3390/jof7100874;
     
  9. Rahimi N, Ho RXY, Chandler KB, De La Cena KOC, Amraei R, Mitchel AJ, Engblom N, Costello CE. The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration. J Biomed Sci. 2021 Sep 09; 28(1):61.View Related Profiles. PMID: 34503512; PMCID: PMC8427838; DOI: 10.1186/s12929-021-00757-z;
     
  10. Amraei R, Yin W, Napoleon MA, Suder EL, Berrigan J, Zhao Q, Olejnik J, Chandler KB, Xia C, Feldman J, Hauser BM, Caradonna TM, Schmidt AG, Gummuluru S, Mühlberger E, Chitalia V, Costello CE, Rahimi N. CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2. ACS Cent Sci. 2021 Jul 28; 7(7):1156-1165.View Related Profiles. PMID: 34341769; PMCID: PMC8265543; DOI: 10.1021/acscentsci.0c01537;
     
Showing 10 of 464 results. Show More