Catherine Costello | Profiles RNS

Catherine E. Costello, PhD

William Fairfield Warren Distinguished Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, Georgetown University
MS, Georgetown University
AB, Emmanuel College

Websites

	Biochemistry Faculty
	Center for Biomedical Mass Spectrometry Faculty
	Google Scholar
	ResearchGate

ORCID : 0000-0003-1594-5122

Catherine Costello came to Boston University in 1994. That year she established the Center for Biomedical Mass Spectrometry, which has become an internationally recognized research center. She holds her primary appointment in the MED Biochemistry Department, with secondary appointments in the Department of Physiology & Biophysics and the Department of Chemistry. Her research, which focuses on determining the structures and functions of biologically important polymers, has revolutionized an important area of biochemistry by providing insights into the structures of molecules responsible for human disease. She is the author or co-author of more than 300 scientific papers, serves on a number of editorial boards of major journals, and has received numerous awards and honors, including the 2010 Field and Franklin Award from the American Chemical Society, one of the highest honors in her field.

Professor
Boston University Chobanian & Avedisian School of Medicine
Chemistry

Research Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

Director
Boston University Chobanian & Avedisian School of Medicine
Center for Biomedical Mass Spectrometry

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Amyloidosis Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Mass Spectrometry analyses, matrix-assisted laser desorption/ionization and electrospray ionization tandem analyses
05/01/2023 - 05/01/2025 (PI)
Nutricia Research B.V

Cellular and humoral immunity in Lyme arthritis
01/08/2019 - 12/31/2023 (Subcontract PI)
Massachusetts General Hospital NIH NIAID
5R01AI144365-05

Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine
08/01/2019 - 12/31/2022 (PI)
NIH/National Institute of General Medical Sciences
5R24GM134210-03

Mass Spectrometry based Characterization of (a) O-glycan GAG (b) Enzymatic reaction on physiologically relevant Glycans and (c) Glycovariants and Charge variants of Biologics
04/01/2021 - 08/31/2022 (PI)
Takeda Pharmaceuticals North America, Inc.

Mass Spectrometry analyses, matrix-assisted laser desorption/ionization and electrospray ionization tandem analyses
12/01/2018 - 12/31/2021 (PI)
Nutricia Research B.V

Investigating PCR Reagent Quality and Its Impact on SARS-CoV-2 Assay Accuracy and Precision
06/01/2021 - 10/31/2021 (PI)
Waters Technologies Corporation

IPA Agreement for Juan Wei
04/05/2019 - 09/27/2019 (PI)
Department of Veterans Administration, Bedford

MASS SPECTROMETRY RESOURCE FOR BIOLOGY AND MEDICINE
06/01/2016 - 05/31/2019 (PI)
NIH/National Institute of General Medical Sciences
4P41GM104603-20

A Thermo-Fisher Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer System
03/06/2018 - 03/05/2019 (PI)
NIH/Office of the Director
1S10OD021728-01A1

A Thermo-Fisher Scientific Q-Exactive HF Mass Spectrometry System
05/01/2016 - 04/30/2017 (Key Person)
PI: Joseph Zaia, PhD
NIH/Office of the Director
1S10OD021651-01

Showing 10 of 24 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2021	Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine	5R24GM134210-03
2020	Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine	5R24GM134210-02
2019	Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine	1R24GM134210-01
2018	A Thermo-Fisher Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer System	1S10OD021728-01A1	2
2017	Mass Spectrometry Resource for Biology and Medicine	3P41GM104603-20S1	148
2016	Mass Spectrometry Resource for Biology and Medicine	4P41GM104603-20	148
2015	Mass Spectrometry Resource for Biology and Medicine	5P41GM104603-19	148
2014	Mass Spectrometry Resource for Biology and Medicine	5P41GM104603-18	148
2013	TAS::75 0872::TAS PROTEOMIC CENTERS: MODIFICATION OF CARDIOVASCULAR PROTEINS BY	268201000031C-5-0-1
2013	Mass Spectrometry Resource for Biology and Medicine	5P41GM104603-17	148

Showing 10 of 417 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

van der Wel H, Garcia AM, Gas-Pascual E, Willis MM, Kim HW, Bandini G, Gaye MM, Costello CE, Samuelson J, West CM. Spindly is a nucleocytosolic O-fucosyltransferase in Dictyostelium and related proteins are widespread in protists and bacteria. Glycobiology. 2023 Apr 19; 33(3):225-244.View Related Profiles.

Costello, Catherine
Samuelson, John
Gaye, Maissa

PMID: 36250576; PMCID: PMC10114647; DOI: 10.1093/glycob/cwac071;

Sanes JT, Costello CE, Steere AC. Heightened Proinflammatory Glycosylation of Borrelia burgdorferi IgG Antibodies in Synovial Fluid in Patients With Antibiotic-Refractory Lyme Arthritis. Arthritis Rheumatol. 2023 Jan 30. PMID: 36716113

Zhu G, Yan W, Wang X, Cheng R, Naowarojna N, Wang K, Wang J, Song H, Wang Y, Liu H, Xia X, Costello CE, Liu X, Zhang L, Liu P. Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues. JACS Au. 2022 Jul 25; 2(7):1686-1698. PMID: 35911443; PMCID: PMC9326825; DOI: 10.1021/jacsau.2c00248;

Gaye MM, Ward CM, Piasecki AJ, Stahl VL, Karagianni A, Costello CE, Ravid K. Characterization of Glycoproteoforms of Integrins a2 and ß1 in Megakaryocytes in the Occurrence of JAK2V617F Mutation-Induced Primary Myelofibrosis. Mol Cell Proteomics. 2022 Apr; 21(4):100213.View Related Profiles.

Costello, Catherine
Ward, Christina
Ravid, Katya
Gaye, Maissa

PMID: 35182768; PMCID: PMC8968581; DOI: 10.1016/j.mcpro.2022.100213;

Chen Z, Wei J, Tang Y, Lin C, Costello CE, Hong P. GlycoDeNovo2: An Improved MS/MS-Based De Novo Glycan Topology Reconstruction Algorithm. J Am Soc Mass Spectrom. 2022 Mar 02; 33(3):436-445. PMID: 35157458; PMCID: PMC9149727; DOI: 10.1021/jasms.1c00288;

Amraei R, Xia C, Olejnik J, White MR, Napoleon MA, Lotfollahzadeh S, Hauser BM, Schmidt AG, Chitalia V, Mühlberger E, Costello CE, Rahimi N. Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells. Proc Natl Acad Sci U S A. 2022 02 08; 119(6).View Related Profiles.

Costello, Catherine
Xia, Chaoshuang
Muhlberger, Elke
Olejnik, Judith
Rahimi, Nader
Chitalia, Vipul

PMID: 35078919; PMCID: PMC8833221; DOI: 10.1073/pnas.2113874119;

Pianta A, Chiumento G, Ramsden K, Wang Q, Strle K, Arvikar S, Costello CE, Steere AC. Identification of Novel, Immunogenic HLA-DR-Presented Prevotella copri Peptides in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2021 12; 73(12):2200-2205. PMID: 34042327; PMCID: PMC8626540; DOI: 10.1002/art.41807;

Liu L, Veis J, Reiter W, Motari E, Costello CE, Samuelson JC, Ammerer G, Levin DE. Regulation of Pkc1 Hyper-Phosphorylation by Genotoxic Stress. J Fungi (Basel). 2021 Oct 17; 7(10).View Related Profiles.

Costello, Catherine
Levin, David
Motari, Edwin
Samuelson, John

PMID: 34682295; PMCID: PMC8541566; DOI: 10.3390/jof7100874;

Rahimi N, Ho RXY, Chandler KB, De La Cena KOC, Amraei R, Mitchel AJ, Engblom N, Costello CE. The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration. J Biomed Sci. 2021 Sep 09; 28(1):61.View Related Profiles.

Costello, Catherine
Rahimi, Nader

PMID: 34503512; PMCID: PMC8427838; DOI: 10.1186/s12929-021-00757-z;

Amraei R, Yin W, Napoleon MA, Suder EL, Berrigan J, Zhao Q, Olejnik J, Chandler KB, Xia C, Feldman J, Hauser BM, Caradonna TM, Schmidt AG, Gummuluru S, Mühlberger E, Chitalia V, Costello CE, Rahimi N. CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2. ACS Cent Sci. 2021 Jul 28; 7(7):1156-1165.View Related Profiles.

Costello, Catherine
Xia, Chaoshuang
Muhlberger, Elke
Olejnik, Judith
Rahimi, Nader
Zhao, Qing
Gummuluru, Suryaram
Chitalia, Vipul
Yin, Wenqing

PMID: 34341769; PMCID: PMC8265543; DOI: 10.1021/acscentsci.0c01537;

Showing 10 of 464 results. Show More

Yan W, Song H, Song F, Guo Y, Wu CH, Her AS, Pu Y, Wang S, Naowarojna N, Weitz A, Hendrich MP, Costello CE, Zhang L, Liu P, Zhang YJ. Retraction Note: Endoperoxide formation by an a-ketoglutarate-dependent mononuclear non-haem iron enzyme. Nature. 2021 May; 593(7860):612. PMID: 34012118; PMCID: PMC8183423; DOI: 10.1038/s41586-021-03527-x;

Hill MM, Dasari S, Mollee P, Merlini G, Costello CE, Hazenberg BPC, Grogan M, Dispenzieri A, Gertz MA, Kourelis T, McPhail ED. The Clinical Impact of Proteomics in Amyloid Typing. Mayo Clin Proc. 2021 05; 96(5):1122-1127. PMID: 33840526; PMCID: PMC8934443; DOI: 10.1016/j.mayocp.2020.12.002;

Sebastiani P, Federico A, Morris M, Gurinovich A, Tanaka T, Chandler KB, Andersen SL, Denis G, Costello CE, Ferrucci L, Jennings L, Glass DJ, Monti S, Perls TT. Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans. Aging Cell. 2021 02; 20(2):e13290.View Related Profiles.

Costello, Catherine
Denis, Gerald
Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 33512769; PMCID: PMC7884029; DOI: 10.1111/acel.13290;

Chandler KB, Mehta N, Leon DR, Suscovich TJ, Alter G, Costello CE. Multi-isotype Glycoproteomic Characterization of Serum Antibody Heavy Chains Reveals Isotype- and Subclass-Specific N-Glycosylation Profiles. Mol Cell Proteomics. 2019 Apr; 18(4):686-703. PMID: 33451651

Wei J, Tang Y, Ridgeway ME, Park MA, Costello CE, Lin C. Accurate Identification of Isomeric Glycans by Trapped Ion Mobility Spectrometry-Electronic Excitation Dissociation Tandem Mass Spectrometry. Anal Chem. 2020 10 06; 92(19):13211-13220. PMID: 32865981; PMCID: PMC8111820; DOI: 10.1021/acs.analchem.0c02374;

Amraie R, Napoleon MA, Yin W, Berrigan J, Suder E, Zhao G, Olejnik J, Gummuluru S, Muhlberger E, Chitalia V, Rahimi N. CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2 and are differentially expressed in lung and kidney epithelial and endothelial cells. bioRxiv. 2020 Jun 23.View Related Profiles.

Costello, Catherine
Xia, Chaoshuang
Muhlberger, Elke
Olejnik, Judith
Rahimi, Nader
Zhao, Qing
Gummuluru, Suryaram
Chitalia, Vipul
Yin, Wenqing

PMID: 32607506; PMCID: PMC7325172; DOI: 10.1101/2020.06.22.165803;

Azab E, Chandler KB, Uda Y, Sun N, Hussein A, Shuwaikan R, Lu V, Costello CE, McComb ME, Divieti Pajevic P. Osteocytes control myeloid cell proliferation and differentiation through Gsa-dependent and -independent mechanisms. FASEB J. 2020 08; 34(8):10191-10211.View Related Profiles.

Hussein, Amira
Costello, Catherine
Chandler, Kevin
McComb, Mark
Sun, Ningyuan
Divieti Pajevic, Paola

PMID: 32557809; PMCID: PMC7688590; DOI: 10.1096/fj.202000366R;

Fuzita FJ, Chandler KB, Haserick JR, Terra WR, Ferreira C, Costello CE. N-glycosylation in Spodoptera frugiperda (Lepidoptera: Noctuidae) midgut membrane-bound glycoproteins. Comp Biochem Physiol B Biochem Mol Biol. 2020 Aug - Sep; 246-247:110464.View Related Profiles.

Costello, Catherine
Haserick, John
Chandler, Kevin

PMID: 32553552; PMCID: PMC8130577; DOI: 10.1016/j.cbpb.2020.110464;

Chandler KB, Alamoud KA, Stahl VL, Nguyen BC, Kartha VK, Bais MV, Nomoto K, Owa T, Monti S, Kukuruzinska MA, Costello CE. ß-Catenin/CBP inhibition alters epidermal growth factor receptor fucosylation status in oral squamous cell carcinoma. Mol Omics. 2020 06 01; 16(3):195-209.View Related Profiles.

Costello, Catherine
Chandler, Kevin
Bais, Manish
Kukuruzinska, Maria
Monti, Stefano

PMID: 32203567; PMCID: PMC7299767; DOI: 10.1039/d0mo00009d;

Wei J, Tang Y, Bai Y, Zaia J, Costello CE, Hong P, Lin C. Toward Automatic and Comprehensive Glycan Characterization by Online PGC-LC-EED MS/MS. Anal Chem. 2020 01 07; 92(1):782-791.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 31829560; PMCID: PMC7082718; DOI: 10.1021/acs.analchem.9b03183;

Yura Y, Chong BSH, Johnson RD, Watanabe Y, Tsukahara Y, Ferran B, Murdoch CE, Behring JB, McComb ME, Costello CE, Janssen-Heininger YMW, Cohen RA, Bachschmid MM, Matsui R. Endothelial cell-specific redox gene modulation inhibits angiogenesis but promotes B16F0 tumor growth in mice. FASEB J. 2019 12; 33(12):14147-14158.View Related Profiles.

Chong, Brian
Costello, Catherine
Murdoch, Colin
Behring, Jessica
McComb, Mark
Bachschmid, Markus
Matsui, Reiko
Cohen, Richard
Tsukahara, Yuko

PMID: 31647879; PMCID: PMC6894059; DOI: 10.1096/fj.201900786R;

Tsybin YO, Bondarenko PV, Artaev VB, Zubarev RA, Costello CE. The Russian Mass Spectrometry Interest Group at ASMS: Over 20 Years of Science and Water Polo. J Am Soc Mass Spectrom. 2019 Oct 01; 30(10):2178-2182. PMID: 31951721

Chandler KB, Leon DR, Kuang J, Meyer RD, Rahimi N, Costello CE. N-Glycosylation regulates ligand-dependent activation and signaling of vascular endothelial growth factor receptor 2 (VEGFR2). J Biol Chem. 2019 08 30; 294(35):13117-13130.View Related Profiles.

Costello, Catherine
Chandler, Kevin
Rahimi, Nader

PMID: 31308178; PMCID: PMC6721943; DOI: 10.1074/jbc.RA119.008643;

Sorvillo N, Mizurini DM, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson PR, Wagner DD. Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury. Circ Res. 2019 08 16; 125(5):507-519. PMID: 31248335; PMCID: PMC6697196; DOI: 10.1161/CIRCRESAHA.118.314571;

Brown Chandler K, Costello CE, Rahimi N. Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis. Cells. 2019 Jun 05; 8(6).View Related Profiles.

Costello, Catherine
Chandler, Kevin
Rahimi, Nader

PMID: 31195728; PMCID: PMC6627046; DOI: 10.3390/cells8060544;

Magistrado-Coxen P, Aqeel Y, Lopez A, Haserick JR, Urbanowicz BR, Costello CE, Samuelson J. The most abundant cyst wall proteins of Acanthamoeba castellanii are lectins that bind cellulose and localize to distinct structures in developing and mature cyst walls. PLoS Negl Trop Dis. 2019 05; 13(5):e0007352.View Related Profiles.

Costello, Catherine
Samuelson, John
Haserick, John
Aqeel, Yousuf

PMID: 31095564; PMCID: PMC6541295; DOI: 10.1371/journal.pntd.0007352;

Campbell MP, Abrahams JL, Rapp E, Struwe WB, Costello CE, Novotny M, Ranzinger R, York WS, Kolarich D, Rudd PM, Kettner C. The minimum information required for a glycomics experiment (MIRAGE) project: LC guidelines. Glycobiology. 2019 05 01; 29(5):349-354. PMID: 30778580

McDonald AJ, Leon DR, Markham KA, Wu B, Heckendorf CF, Schilling K, Showalter HD, Andrews PC, McComb ME, Pushie MJ, Costello CE, Millhauser GL, Harris DA. Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking, MS/MS, and NMR. Structure. 2019 06 04; 27(6):907-922.e5.View Related Profiles.

Wu, Bei
Costello, Catherine
Harris, David
McComb, Mark

PMID: 30956132; PMCID: PMC6736647; DOI: 10.1016/j.str.2019.03.008;

Shao D, Yao C, Kim MH, Fry J, Cohen RA, Costello CE, Matsui R, Seta F, McComb ME, Bachschmid MM. Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators. Redox Biol. 2019 04; 22:101150.View Related Profiles.

Costello, Catherine
Yao, Chunxiang
Shao, Di
Seta, Francesca
Fry, Jessica
McComb, Mark
Bachschmid, Markus
Matsui, Reiko
Cohen, Richard

PMID: 30877853; PMCID: PMC6423473; DOI: 10.1016/j.redox.2019.101150;

Nguyen DN, Xu B, Stanfield RL, Bailey JK, Horiya S, Temme JS, Leon DR, LaBranche CC, Montefiori DC, Costello CE, Wilson IA, Krauss IJ. Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities. ACS Cent Sci. 2019 Feb 27; 5(2):237-249. PMID: 30834312; PMCID: PMC6396197; DOI: 10.1021/acscentsci.8b00588;

Wei J, Wu J, Tang Y, Ridgeway ME, Park MA, Costello CE, Zaia J, Lin C. Characterization and Quantification of Highly Sulfated Glycosaminoglycan Isomers by Gated-Trapped Ion Mobility Spectrometry Negative Electron Transfer Dissociation MS/MS. Anal Chem. 2019 02 19; 91(4):2994-3001.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 30649866; PMCID: PMC6441329; DOI: 10.1021/acs.analchem.8b05283;

Costello, Catherine
Chandler, Kevin

PMID: 30659065; PMCID: PMC6442369; DOI: 10.1074/mcp.RA118.001185;

Bandini G, Leon DR, Hoppe CM, Zhang Y, Agop-Nersesian C, Shears MJ, Mahal LK, Routier FH, Costello CE, Samuelson J. O-Fucosylation of thrombospondin-like repeats is required for processing of microneme protein 2 and for efficient host cell invasion by Toxoplasma gondii tachyzoites. J Biol Chem. 2019 02 08; 294(6):1967-1983.View Related Profiles.

Costello, Catherine
Bandini, Giulia
Samuelson, John

PMID: 30538131; PMCID: PMC6369279; DOI: 10.1074/jbc.RA118.005179;

Ho RX, Meyer RD, Chandler KB, Ersoy E, Park M, Bondzie PA, Rahimi N, Xu H, Costello CE, Rahimi N. MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth. J Mol Cell Biol. 2018 06 01; 10(3):195-204.View Related Profiles.

Costello, Catherine
Xu, Huihong
Chandler, Kevin
Rahimi, Nader
Bondzie, Philip Apraku

PMID: 29329397; PMCID: PMC6025234; DOI: 10.1093/jmcb/mjy002;

Hoppe CM, Albuquerque-Wendt A, Bandini G, Leon DR, Shcherbakova A, Buettner FFR, Izquierdo L, Costello CE, Bakker H, Routier FH. Apicomplexan C-Mannosyltransferases Modify Thrombospondin Type I-containing Adhesins of the TRAP Family. Glycobiology. 2018 05 01; 28(5):333-343.View Related Profiles.

Costello, Catherine
Bandini, Giulia

PMID: 29432542; PMCID: PMC6018953; DOI: 10.1093/glycob/cwy013;

Khatri K, Pu Y, Klein JA, Wei J, Costello CE, Lin C, Zaia J. Comparison of Collisional and Electron-Based Dissociation Modes for Middle-Down Analysis of Multiply Glycosylated Peptides. J Am Soc Mass Spectrom. 2018 06; 29(6):1075-1085.View Related Profiles.

Costello, Catherine
Zaia, Joseph
Khatri, Kshitij

PMID: 29663256; PMCID: PMC6004259; DOI: 10.1007/s13361-018-1909-y;

Tang Y, Wei J, Costello CE, Lin C. Characterization of Isomeric Glycans by Reversed Phase Liquid Chromatography-Electronic Excitation Dissociation Tandem Mass Spectrometry. J Am Soc Mass Spectrom. 2018 06; 29(6):1295-1307. PMID: 29654534; PMCID: PMC6004250; DOI: 10.1007/s13361-018-1943-9;

Irani S, Naowarojna N, Tang Y, Kathuria KR, Wang S, Dhembi A, Lee N, Yan W, Lyu H, Costello CE, Liu P, Zhang YJ. Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism. Cell Chem Biol. 2018 05 17; 25(5):519-529.e4. PMID: 29503207; PMCID: PMC5959753; DOI: 10.1016/j.chembiol.2018.02.002;

Tang Y, Pu Y, Gao J, Hong P, Costello CE, Lin C. De Novo Glycan Sequencing by Electronic Excitation Dissociation and Fixed-Charge Derivatization. Anal Chem. 2018 03 20; 90(6):3793-3801. PMID: 29443510; PMCID: PMC6521716; DOI: 10.1021/acs.analchem.7b04077;

Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B. How many human proteoforms are there? Nat Chem Biol. 2018 02 14; 14(3):206-214. PMID: 29443976; PMCID: PMC5837046; DOI: 10.1038/nchembio.2576;

Shao W, Pedrioli PGA, Wolski W, Scurtescu C, Schmid E, Vizcaíno JA, Courcelles M, Schuster H, Kowalewski D, Marino F, Arlehamn CSL, Vaughan K, Peters B, Sette A, Ottenhoff THM, Meijgaarden KE, Nieuwenhuizen N, Kaufmann SHE, Schlapbach R, Castle JC, Nesvizhskii AI, Nielsen M, Deutsch EW, Campbell DS, Moritz RL, Zubarev RA, Ytterberg AJ, Purcell AW, Marcilla M, Paradela A, Wang Q, Costello CE, Ternette N, van Veelen PA, van Els CACM, Heck AJR, de Souza GA, Sollid LM, Admon A, Stevanovic S, Rammensee HG, Thibault P, Perreault C, Bassani-Sternberg M, Aebersold R, Caron E. The SysteMHC Atlas project. Nucleic Acids Res. 2018 01 04; 46(D1):D1237-D1247. PMID: 28985418; PMCID: PMC5753376; DOI: 10.1093/nar/gkx664;

Haserick JR, Klein JA, Costello CE, Samuelson J. Cryptosporidium parvum vaccine candidates are incompletely modified with O-linked-N-acetylgalactosamine or contain N-terminal N-myristate and S-palmitate. PLoS One. 2017; 12(8):e0182395.View Related Profiles.

Costello, Catherine
Samuelson, John
Haserick, John

PMID: 28792526; PMCID: PMC5549699; DOI: 10.1371/journal.pone.0182395;

Saito Â, Souza EE, Costa FC, Meirelles GV, Gonçalves KA, Santos MT, Bressan GC, McComb ME, Costello CE, Whelan SA, Kobarg J. Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation. J Proteome Res. 2017 Sep 01; 16(9):3147-3157.View Related Profiles.

Costello, Catherine
McComb, Mark
Whelan, Stephen

PMID: 28695742; PMCID: PMC6699623; DOI: 10.1021/acs.jproteome.7b00001;

Pianta A, Arvikar SL, Strle K, Drouin EE, Wang Q, Costello CE, Steere AC. Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest. 2017 Aug 01; 127(8):2946-2956. PMID: 28650341; PMCID: PMC5531397; DOI: 10.1172/JCI93450;

Khatri K, Klein JA, Haserick JR, Leon DR, Costello CE, McComb ME, Zaia J. Microfluidic Capillary Electrophoresis-Mass Spectrometry for Analysis of Monosaccharides, Oligosaccharides, and Glycopeptides. Anal Chem. 2017 06 20; 89(12):6645-6655.View Related Profiles.

Costello, Catherine
Haserick, John
Zaia, Joseph
Khatri, Kshitij
McComb, Mark

PMID: 28530388; PMCID: PMC5554952; DOI: 10.1021/acs.analchem.7b00875;

Pianta A, Arvikar S, Strle K, Drouin EE, Wang Q, Costello CE, Steere AC. Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017 May; 69(5):964-975. PMID: 27863183; PMCID: PMC5406252; DOI: 10.1002/art.40003;

Glaskin RS, Khatri K, Wang Q, Zaia J, Costello CE. Construction of a Database of Collision Cross Section Values for Glycopeptides, Glycans, and Peptides Determined by IM-MS. Anal Chem. 2017 04 18; 89(8):4452-4460.View Related Profiles.

Costello, Catherine
Zaia, Joseph
Khatri, Kshitij
Wang, Qi
Glaskin, Rebecca

PMID: 28323417; PMCID: PMC5766263; DOI: 10.1021/acs.analchem.6b04146;

Haserick JR, Leon DR, Samuelson J, Costello CE. Asparagine-Linked Glycans of Cryptosporidium parvum Contain a Single Long Arm, Are Barely Processed in the Endoplasmic Reticulum (ER) or Golgi, and Show a Strong Bias for Sites with Threonine. Mol Cell Proteomics. 2017 Apr; 16(4 suppl 1):S42-S53.View Related Profiles.

Costello, Catherine
Samuelson, John
Haserick, John

PMID: 28179475; PMCID: PMC5393390; DOI: 10.1074/mcp.M116.066035;

Chandler KB, Leon DR, Meyer RD, Rahimi N, Costello CE. Site-Specific N-Glycosylation of Endothelial Cell Receptor Tyrosine Kinase VEGFR-2. J Proteome Res. 2017 Feb 03; 16(2):677-688.View Related Profiles.

Costello, Catherine
Chandler, Kevin
Rahimi, Nader

PMID: 27966990; PMCID: PMC5291786; DOI: 10.1021/acs.jproteome.6b00738;

Liu Y, McBride R, Stoll M, Palma AS, Silva L, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Haslam SM, Karlsson NG, Khoo KH, Kolarich D, Novotny MV, Packer NH, Ranzinger R, Rapp E, Rudd PM, Struwe WB, Tiemeyer M, Wells L, York WS, Zaia J, Kettner C, Paulson JC, Feizi T, Smith DF. The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data. Glycobiology. 2017 04; 27(4):280-284.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 27993942; PMCID: PMC5444268; DOI: 10.1093/glycob/cww118;

Wang YH, Meyer RD, Bondzie PA, Jiang Y, Rahimi I, Rezazadeh K, Mehta M, Laver NM, Costello CE, Rahimi N. IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function. J Mol Biol. 2016 Dec 04; 428(24 Pt B):5019-5033.View Related Profiles.

Costello, Catherine
Rezazadeh, Kobra
Mehta, Manisha
Rahimi, Nader
Bondzie, Philip Apraku

PMID: 27838321; PMCID: PMC5138093; DOI: 10.1016/j.jmb.2016.11.003;

Lu Y, Jiang Y, Prokaeva T, Connors LH, Costello CE. Oxidative Post-Translational Modifications of an Amyloidogenic Immunoglobulin Light Chain Protein. Int J Mass Spectrom. 2017 05; 416:71-79.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Prokaeva, Tatiana
Lu, Yanyan

PMID: 29358899; PMCID: PMC5774984; DOI: 10.1016/j.ijms.2016.11.006;

Wang Q, Drouin EE, Yao C, Zhang J, Huang Y, Leon DR, Steere AC, Costello CE. Immunogenic HLA-DR-Presented Self-Peptides Identified Directly from Clinical Samples of Synovial Tissue, Synovial Fluid, or Peripheral Blood in Patients with Rheumatoid Arthritis or Lyme Arthritis. J Proteome Res. 2017 Jan 06; 16(1):122-136.View Related Profiles.

Costello, Catherine
Yao, Chunxiang
Wang, Qi
Huang, Yu

PMID: 27726376; PMCID: PMC5766322; DOI: 10.1021/acs.jproteome.6b00386;

Villar RF, Patel J, Weaver GC, Kanekiyo M, Wheatley AK, Yassine HM, Costello CE, Chandler KB, McTamney PM, Nabel GJ, McDermott AB, Mascola JR, Carr SA, Lingwood D. Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation. Sci Rep. 2016 10 31; 6:36298.View Related Profiles.

Costello, Catherine
Chandler, Kevin

PMID: 27796362; PMCID: PMC5087089; DOI: 10.1038/srep36298;

Bandini G, Haserick JR, Motari E, Ouologuem DT, Lourido S, Roos DS, Costello CE, Robbins PW, Samuelson J. O-fucosylated glycoproteins form assemblies in close proximity to the nuclear pore complexes of Toxoplasma gondii. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11567-11572.View Related Profiles.

Costello, Catherine
Motari, Edwin
Bandini, Giulia
Samuelson, John
Haserick, John
Robbins, Phillips

PMID: 27663739; PMCID: PMC5068260; DOI: 10.1073/pnas.1613653113;

Struwe WB, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Ten Feizi, Haslam SM, Karlsson NG, Khoo KH, Kolarich D, Liu Y, McBride R, Novotny MV, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Tiemeyer M, Wells L, York WS, Zaia J, Kettner C. The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets. Glycobiology. 2016 Sep; 26(9):907-910.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 27654115; PMCID: PMC5045532; DOI: 10.1093/glycob/cww082;

Zheng X, Zhang X, Schocker NS, Renslow RS, Orton DJ, Khamsi J, Ashmus RA, Almeida IC, Tang K, Costello CE, Smith RD, Michael K, Baker ES. Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses. Anal Bioanal Chem. 2017 Jan; 409(2):467-476. PMID: 27604268; PMCID: PMC5434874; DOI: 10.1007/s00216-016-9866-4;

Ma J, Banerjee P, Whelan SA, Liu T, Wei AC, Ramirez-Correa G, McComb ME, Costello CE, O'Rourke B, Murphy A, Hart GW. Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts. J Proteome Res. 2016 Jul 01; 15(7):2254-64.View Related Profiles.

Costello, Catherine
McComb, Mark
Whelan, Stephen

PMID: 27213235; PMCID: PMC7814404; DOI: 10.1021/acs.jproteome.6b00250;

Zhang Z, Costa FC, Tan EP, Bushue N, DiTacchio L, Costello CE, McComb ME, Whelan SA, Peterson KR, Slawson C. O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2ß Protein at the A?-Globin Promoter. J Biol Chem. 2016 Jul 22; 291(30):15628-40.View Related Profiles.

Costello, Catherine
McComb, Mark
Whelan, Stephen

PMID: 27231347; PMCID: PMC4957047; DOI: 10.1074/jbc.M116.721928;

Premasiri WR, Lee JC, Sauer-Budge A, Théberge R, Costello CE, Ziegler LD. The biochemical origins of the surface-enhanced Raman spectra of bacteria: a metabolomics profiling by SERS. Anal Bioanal Chem. 2016 Jul; 408(17):4631-47.View Related Profiles.

Costello, Catherine
Ziegler, Lawrence
Theberge, Roger

PMID: 27100230; PMCID: PMC4911336; DOI: 10.1007/s00216-016-9540-x;

Lucena MC, Carvalho-Cruz P, Donadio JL, Oliveira IA, de Queiroz RM, Marinho-Carvalho MM, Sola-Penna M, de Paula IF, Gondim KC, McComb ME, Costello CE, Whelan SA, Todeschini AR, Dias WB. Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation. J Biol Chem. 2016 Jun 17; 291(25):12917-29.View Related Profiles.

Costello, Catherine
McComb, Mark
Whelan, Stephen

PMID: 27129262; PMCID: PMC4933211; DOI: 10.1074/jbc.M116.729236;

Ridgeway ME, Wolff JJ, Silveira JA, Lin C, Costello CE, Park MA. Gated Trapped Ion Mobility Spectrometry Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Int J Ion Mobil Spectrom. 2016 Sep; 19(2):77-85. PMID: 27667964; PMCID: PMC5029861; DOI: 10.1007/s12127-016-0197-0;

Chandler KB, Costello CE. Glycomics and glycoproteomics of membrane proteins and cell-surface receptors: Present trends and future opportunities. Electrophoresis. 2016 Jun; 37(11):1407-19.View Related Profiles.

Costello, Catherine
Chandler, Kevin

PMID: 26872045; PMCID: PMC4889498; DOI: 10.1002/elps.201500552;

Pu Y, Ridgeway ME, Glaskin RS, Park MA, Costello CE, Lin C. Separation and Identification of Isomeric Glycans by Selected Accumulation-Trapped Ion Mobility Spectrometry-Electron Activated Dissociation Tandem Mass Spectrometry. Anal Chem. 2016 Apr 05; 88(7):3440-3.View Related Profiles.

Costello, Catherine
Lin, Cheng
Glaskin, Rebecca

PMID: 26959868; PMCID: PMC4821751; DOI: 10.1021/acs.analchem.6b00041;

Crowley JT, Strle K, Drouin EE, Pianta A, Arvikar SL, Wang Q, Costello CE, Steere AC. Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis. J Autoimmun. 2016 May; 69:24-37. PMID: 26922382; PMCID: PMC4826816; DOI: 10.1016/j.jaut.2016.02.005;

Suematsu T, Zhang L, Aphasizheva I, Monti S, Huang L, Wang Q, Costello CE, Aphasizhev R. Antisense Transcripts Delimit Exonucleolytic Activity of the Mitochondrial 3' Processome to Generate Guide RNAs. Mol Cell. 2016 Feb 4; 61(3):364-78.View Related Profiles.

Costello, Catherine
Zhang, Liye
Wang, Qi
Afasizhev, Ruslan
Monti, Stefano
Suematsu, Takuma

PMID: 26833087; PMCID: PMC4744118; DOI: 10.1016/j.molcel.2016.01.004;

Aphasizheva I, Maslov DA, Qian Y, Huang L, Wang Q, Costello CE, Aphasizhev R. Ribosome-associated pentatricopeptide repeat proteins function as translational activators in mitochondria of trypanosomes. Mol Microbiol. 2016 Mar; 99(6):1043-58.View Related Profiles.

Costello, Catherine
Wang, Qi
Afasizhev, Ruslan

PMID: 26713541; PMCID: PMC4855836; DOI: 10.1111/mmi.13287;

Ji Y, Bachschmid MM, Costello CE, Lin C. S- to N-Palmitoyl Transfer During Proteomic Sample Preparation. J Am Soc Mass Spectrom. 2016 Apr; 27(4):677-85.View Related Profiles.

Costello, Catherine
Lin, Cheng
Bachschmid, Markus
Ji, Yuhuan

PMID: 26729453; PMCID: PMC4794353; DOI: 10.1007/s13361-015-1319-3;

Pianta A, Drouin EE, Arvikar SL, Wang Q, Costello CE, Steere AC. OP0199 Immune Responses To Prevotella copri in Patients with Rheumatoid Arthritis. Annals of the Rheumatic Diseases. 2016; 75(Suppl 2):132.1-132. View Publication

Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025.View Related Profiles.

Sverdlov, Aaron
Elezaby, Aly
Costello, Catherine
Yao, Chunxiang
Siwik, Deborah
Shao, Di
Seta, Francesca
Behring, Jessica
McComb, Mark
Bachschmid, Markus
Matsui, Reiko
Cohen, Richard
Whelan, Stephen
Colucci, Wilson
Yin, Xiaoyan

PMID: 26642319; PMCID: PMC4671598; DOI: 10.1371/journal.pone.0144025;

Yu X, Sargaeva NP, Thompson CJ, Costello CE, Lin C. In-Source Decay Characterization of Isoaspartate and ß-Peptides. Int J Mass Spectrom. 2015 Nov 15; 390:101-109.View Related Profiles.

Costello, Catherine
Lin, Cheng

PMID: 26644780; PMCID: PMC4669973; DOI: 10.1016/j.ijms.2015.07.013;

Yan W, Song H, Song F, Guo Y, Wu CH, Sae Her A, Pu Y, Wang S, Naowarojna N, Weitz A, Hendrich MP, Costello CE, Zhang L, Liu P, Zhang YJ. Endoperoxide formation by an a-ketoglutarate-dependent mononuclear non-haem iron enzyme. Nature. 2015 Nov 26; 527(7579):539-43.View Related Profiles.

Costello, Catherine
Liu, Pinghua

PMID: 26524521; PMCID: PMC4804460; DOI: 10.1038/nature15519;

Huang Y, Pu Y, Yu X, Costello CE, Lin C. Mechanistic Study on Electronic Excitation Dissociation of the Cellobiose-Na(+) Complex. J Am Soc Mass Spectrom. 2016 Feb; 27(2):319-28.View Related Profiles.

Costello, Catherine
Lin, Cheng
Huang, Yiqun

PMID: 26432580; PMCID: PMC4724539; DOI: 10.1007/s13361-015-1277-9;

Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY. RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. EMBO J. 2015 Sep 14; 34(18):2363-82.View Related Profiles.

Meriin, Anatoli
Costello, Catherine
McComb, Mark
Sherman, Michael
Zaarur, Nava

PMID: 26303906; PMCID: PMC4570522; DOI: 10.15252/embj.201591245;

Lindsey ML, Mayr M, Gomes AV, Delles C, Arrell DK, Murphy AM, Lange RA, Costello CE, Jin YF, Laskowitz DT, Sam F, Terzic A, Van Eyk J, Srinivas PR. Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circulation. 2015 Sep 1; 132(9):852-72.View Related Profiles.

Costello, Catherine
Sam, Flora

PMID: 26195497; DOI: 10.1161/CIR.0000000000000226;

Pianta A, Drouin EE, Crowley JT, Arvikar S, Strle K, Costello CE, Steere AC. Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis. Clin Immunol. 2015 Oct; 160(2):336-41. PMID: 26187145; PMCID: PMC4582008; DOI: 10.1016/j.clim.2015.07.005;

Baker ES, Burnum-Johnson KE, Ibrahim YM, Orton DJ, Monroe ME, Kelly RT, Moore RJ, Zhang X, Théberge R, Costello CE, Smith RD. Enhancing bottom-up and top-down proteomic measurements with ion mobility separations. Proteomics. 2015 Aug; 15(16):2766-76.View Related Profiles.

Costello, Catherine
Theberge, Roger

PMID: 26046661; PMCID: PMC4534090; DOI: 10.1002/pmic.201500048;

Srinivasan S, Chitalia V, Meyer RD, Hartsough E, Mehta M, Harrold I, Anderson N, Feng H, Smith LE, Jiang Y, Costello CE, Rahimi N. Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis. 2015 Oct; 18(4):449-62.View Related Profiles.

Costello, Catherine
Feng, Hui
Mehta, Manisha
Rahimi, Nader
Chitalia, Vipul

PMID: 26059764; PMCID: PMC4600037; DOI: 10.1007/s10456-015-9468-3;

Crowley JT, Drouin EE, Pianta A, Strle K, Wang Q, Costello CE, Steere AC. A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients With Lyme Disease. J Infect Dis. 2015 Dec 1; 212(11):1841-50. PMID: 26014802; PMCID: PMC4633766; DOI: 10.1093/infdis/jiv310;

Théberge R, Dikler S, Heckendorf C, Chui DH, Costello CE, McComb ME. MALDI-ISD Mass Spectrometry Analysis of Hemoglobin Variants: a Top-Down Approach to the Characterization of Hemoglobinopathies. J Am Soc Mass Spectrom. 2015 Aug; 26(8):1299-310.View Related Profiles.

Costello, Catherine
Chui, David
McComb, Mark
Theberge, Roger

PMID: 26002792; PMCID: PMC4496427; DOI: 10.1007/s13361-015-1164-4;

Ji Y, Liu M, Bachschmid MM, Costello CE, Lin C. Surfactant-Induced Artifacts during Proteomic Sample Preparation. Anal Chem. 2015 Jun 2; 87(11):5500-4.View Related Profiles.

Costello, Catherine
Lin, Cheng
Bachschmid, Markus

PMID: 25945600; PMCID: PMC4574305; DOI: 10.1021/acs.analchem.5b00249;

Yao C, Yu J, Taylor L, Polgar P, McComb ME, Costello CE. Protein Expression by Human Pulmonary Artery Smooth Muscle Cells Containing a BMPR2 Mutation and the Action of ET-1 as Determined by Proteomic Mass Spectrometry. Int J Mass Spectrom. 2015 Feb 15; 378:347-359.View Related Profiles.

Costello, Catherine
Yao, Chunxiang
Taylor, Linda
McComb, Mark
Polgar, Peter

PMID: 25866469; PMCID: PMC4387548; DOI: 10.1016/j.ijms.2014.10.006;

Samuelson J, Bandini G, Motari E, Costello CE, Lourido S, West C, Robbins PW. Glycobiology. Evidence for a fucosylated protein complex associated with the nuclear membrane of Toxoplasma gondii. 2015.
Pianta A, Drouin EE, Wang Q, Arvikar SL, Costello CE, Steere AC. OP0116 Identification of N-Acetylglucosamine-6-Sulfatase and Filamin a as Novel Targets of Autoimmune T and B Cell Responses in Rheumatoid Arthritis. Annals of the Rheumatic Diseases. 2015; 74(Suppl 2):112.2-112. View Publication

Rahimi N, Costello CE. Emerging roles of post-translational modifications in signal transduction and angiogenesis. Proteomics. 2015 Jan; 15(2-3):300-9.View Related Profiles.

Costello, Catherine
Rahimi, Nader

PMID: 25161153; PMCID: PMC4297243; DOI: 10.1002/pmic.201400183;

de Souza EE, Meirelles GV, Godoy BB, Perez AM, Smetana JH, Doxsey SJ, McComb ME, Costello CE, Whelan SA, Kobarg J. Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6. J Proteome Res. 2014 Sep 5; 13(9):4074-90.View Related Profiles.

Costello, Catherine
McComb, Mark
Whelan, Stephen

PMID: 25093993; PMCID: PMC4156247; DOI: 10.1021/pr500437x;

Jiang J, Tian F, Cai Y, Qian X, Costello CE, Ying W. Site-specific qualitative and quantitative analysis of the N- and O-glycoforms in recombinant human erythropoietin. Anal Bioanal Chem. 2014 Oct; 406(25):6265-74. PMID: 25080026; PMCID: PMC4422759; DOI: 10.1007/s00216-014-8037-8;

Zhou Y, Park H, Kim P, Jiang Y, Costello CE. Surface oxidation under ambient air--not only a fast and economical method to identify double bond positions in unsaturated lipids but also a reminder of proper lipid processing. Anal Chem. 2014 Jun 17; 86(12):5697-705.View Related Profiles.

Costello, Catherine
Park, Hyejung

PMID: 24832382; PMCID: PMC4066906; DOI: 10.1021/ac404214a;

Huang Y, Pu Y, Yu X, Costello CE, Lin C. Mechanistic study on electron capture dissociation of the oligosaccharide-Mg²? complex. J Am Soc Mass Spectrom. 2014 Aug; 25(8):1451-60.View Related Profiles.

Costello, Catherine
Lin, Cheng
Huang, Yiqun

PMID: 24845360; PMCID: PMC4108535; DOI: 10.1007/s13361-014-0921-0;

Bourgoin-Voillard S, Leymarie N, Costello CE. Top-down tandem mass spectrometry on RNase A and B using a Qh/FT-ICR hybrid mass spectrometer. Proteomics. 2014 May; 14(10):1174-84.View Related Profiles.

Costello, Catherine
Leymarie, Nancy
Bourgoin-Voillard, Sandrine

PMID: 24687996; PMCID: PMC4095805; DOI: 10.1002/pmic.201300433;

York WS, Agravat S, Aoki-Kinoshita KF, McBride R, Campbell MP, Costello CE, Dell A, Feizi T, Haslam SM, Karlsson N, Khoo KH, Kolarich D, Liu Y, Novotny M, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Struwe WB, Tiemeyer M, Wells L, Zaia J, Kettner C. MIRAGE: the minimum information required for a glycomics experiment. Glycobiology. 2014 May; 24(5):402-6.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 24653214; PMCID: PMC3976285; DOI: 10.1093/glycob/cwu018;

Gault J, Malosse C, Machata S, Millien C, Podglajen I, Ploy MC, Costello CE, Duménil G, Chamot-Rooke J. Complete posttranslational modification mapping of pathogenic Neisseria meningitidis pilins requires top-down mass spectrometry. Proteomics. 2014 May; 14(10):1141-51. PMID: 24459079; PMCID: PMC4201860; DOI: 10.1002/pmic.201300394;

Park H, Zhou Y, Costello CE. Direct analysis of sialylated or sulfated glycosphingolipids and other polar and neutral lipids using TLC-MS interfaces. J Lipid Res. 2014 Apr; 55(4):773-81.View Related Profiles.

Costello, Catherine
Park, Hyejung

PMID: 24482490; PMCID: PMC3966711; DOI: 10.1194/jlr.D046128;

Behring JB, Kumar V, Whelan SA, Chauhan P, Siwik DA, Costello CE, Colucci WS, Cohen RA, McComb ME, Bachschmid MM. Does reversible cysteine oxidation link the Western diet to cardiac dysfunction? FASEB J. 2014 May; 28(5):1975-87.View Related Profiles.

Costello, Catherine
Siwik, Deborah
Behring, Jessica
McComb, Mark
Bachschmid, Markus
Cohen, Richard
Whelan, Stephen
Kumar, Vikas
Colucci, Wilson

PMID: 24469991; PMCID: PMC4046179; DOI: 10.1096/fj.13-233445;

Pianta A, Drouin EE, Arvikar SL, Costello CE, Steere AC. Identification of annexin A-2 as an autoantigen in rheumatoid arthritis and in Lyme arthritis. Arthritis & Rheumatology. 2014; 66.

Ji Y, Leymarie N, Haeussler DJ, Bachschmid MM, Costello CE, Lin C. Direct detection of S-palmitoylation by mass spectrometry. Anal Chem. 2013 Dec 17; 85(24):11952-9.View Related Profiles.

Costello, Catherine
Lin, Cheng
Haeussler, Dagmar
Bachschmid, Markus
Leymarie, Nancy
Ji, Yuhuan

PMID: 24279456; PMCID: PMC3912867; DOI: 10.1021/ac402850s;

Hartsough EJ, Meyer RD, Chitalia V, Jiang Y, Marquez VE, Zhdanova IV, Weinberg J, Costello CE, Rahimi N. Lysine methylation promotes VEGFR-2 activation and angiogenesis. Sci Signal. 2013 Dec 3; 6(304):ra104.View Related Profiles.

Costello, Catherine
Zhdanova, Irina
Weinberg, Janice
Rahimi, Nader
Meyer, Rosana
Chitalia, Vipul

PMID: 24300896; PMCID: PMC4108444; DOI: 10.1126/scisignal.2004289;

Spencer JL, Bhatia VN, Whelan SA, Costello CE, McComb ME. STRAP PTM: Software Tool for Rapid Annotation and Differential Comparison of Protein Post-Translational Modifications. Curr Protoc Bioinformatics. 2013 Dec; 44:13.22.1-36.View Related Profiles.

Costello, Catherine
Spencer, Jean
McComb, Mark
Whelan, Stephen

PMID: 25422678; PMCID: PMC4240648; DOI: 10.1002/0471250953.bi1322s44;

Huang Y, Yu X, Mao Y, Costello CE, Zaia J, Lin C. De novo sequencing of heparan sulfate oligosaccharides by electron-activated dissociation. Anal Chem. 2013 Dec 17; 85(24):11979-86.View Related Profiles.

Costello, Catherine
Lin, Cheng
Zaia, Joseph
Mao, Yang
Huang, Yu

PMID: 24224699; PMCID: PMC3912864; DOI: 10.1021/ac402931j;

Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89.View Related Profiles.

Seaton, Barbara
Costello, Catherine
Madico, Guillermo
Sharon, Jacqueline
Zaia, Joseph
Rynkiewicz, Michael
Wang, Qi
Lu, Zhaohua

PMID: 23844703; PMCID: PMC3800442; DOI: 10.1111/imm.12150;

Yu X, Jiang Y, Chen Y, Huang Y, Costello CE, Lin C. Detailed glycan structural characterization by electronic excitation dissociation. Anal Chem. 2013 Nov 5; 85(21):10017-21.View Related Profiles.

Costello, Catherine
Lin, Cheng

PMID: 24080071; PMCID: PMC3851312; DOI: 10.1021/ac402886q;

Kehasse A, Rich CB, Lee A, McComb ME, Costello CE, Trinkaus-Randall V. Epithelial wounds induce differential phosphorylation changes in response to purinergic and EGF receptor activation. Am J Pathol. 2013 Dec; 183(6):1841-52.View Related Profiles.

Kehasse, Amanuel
Costello, Catherine
McComb, Mark
Trinkaus-Randall, Vickery

PMID: 24095926; PMCID: PMC5745543; DOI: 10.1016/j.ajpath.2013.08.015;

Bushkin GG, Motari E, Carpentieri A, Dubey JP, Costello CE, Robbins PW, Samuelson J. Evidence for a structural role for acid-fast lipids in oocyst walls of Cryptosporidium, Toxoplasma, and Eimeria. MBio. 2013; 4(5):e00387-13.View Related Profiles.

Costello, Catherine
Motari, Edwin
Bushkin, Gary
Samuelson, John
Robbins, Phillips

PMID: 24003177; PMCID: PMC3760245; DOI: 10.1128/mBio.00387-13;

Leo G, Altucci C, Bourgoin-Voillard S, Gravagnuolo AM, Esposito R, Marino G, Costello CE, Velotta R, Birolo L. Ultraviolet laser-induced cross-linking in peptides. Rapid Commun Mass Spectrom. 2013 Jul 30; 27(14):1660-8.View Related Profiles.

Costello, Catherine
Bourgoin-Voillard, Sandrine

PMID: 23754800; PMCID: PMC3882510; DOI: 10.1002/rcm.6610;

Han L, Costello CE. Mass spectrometry of glycans. Biochemistry (Mosc). 2013 Jul; 78(7):710-20. PMID: 24010834; PMCID: PMC4104780; DOI: 10.1134/S0006297913070031;

Smith BW, Rozelle SS, Leung A, Ubellacker J, Parks A, Nah SK, French D, Gadue P, Monti S, Chui DH, Steinberg MH, Frelinger AL, Michelson AD, Theberge R, McComb ME, Costello CE, Kotton DN, Mostoslavsky G, Sherr DH, Murphy GJ. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood. 2013 Jul 18; 122(3):376-85.View Related Profiles.

Leung, Amy
Costello, Catherine
Kotton, Darrell
Sherr, David
Chui, David
Murphy, George
Mostoslavsky, Gustavo
McComb, Mark
Steinberg, Martin
Theberge, Roger
Monti, Stefano

PMID: 23723449; PMCID: PMC3716202; DOI: 10.1182/blood-2012-11-466722;

Singh BN, Hayes GR, Han L, Heiss C, Azadi P, Costello CE, Fichorova R. Glycobiology. Biochemical nature of lectin-binding ceramide-phosphatidylinositol glycolipid membrane anchor from Trichomonas vaginalis. 2013.

Drouin EE, Seward RJ, Strle K, McHugh G, Katchar K, Londoño D, Yao C, Costello CE, Steere AC. A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease. Arthritis Rheum. 2013 Jan; 65(1):186-96.View Related Profiles.

Costello, Catherine
Yao, Chunxiang

PMID: 23044924; PMCID: PMC3535550; DOI: 10.1002/art.37732;

Whelan SA, Theberge R, Spencer JL, Griffin PJ, Xing C, Steinberg M, Costello CE, Klings ES, Mccomb ME. 61st ASMS Conference on Mass Spectrometry and Allied Topics. Protein and Post-Translational Modification Markers in Sickle Cell Disease. 2013.
Motari E, Bushkin GG, Dubey JP, Costello CE, Robbins PW, Samuelson J. Glycobiology. The oocyst walls of Toxoplasma have an inner layer of beta-1,3-glucan (like fungi) and an outer layer of acid-fast lipids (like mycobacteria). 2013.
Mccomb ME, Whelan SA, Spencer JL, Heckendorg CF, Bachschmid MM, Siwik DA, Colucci WS, Cohen RA, Costello CE. Experimental Biology. Characterization of Post-Translational Modifications Related to Cardiovascular Disease. FASEB J. Boston. 2013; 27:663.10.
Whelan SA, Mccomb ME, Spencer JL, Heckendorf CF, Bachschmid MM, Siwik DA, Colucci WS, Cohen RA, Costello CE. Experimental Biology FASEB J. Metabolic Disorder in a Mouse Model on an American Diet: Proteomic Analysis of Cardiovascular Disease. Boston. 2013; 27:794.17.
Leon D, Yu X, Lin C, Leymarie N, Loo R, Loo JA, Gunsalus R, Costello CE. Glycobiology. The N-linked Octasaccharide of M. mazei Does Not Resemble the Eukaryotic or Bacterial N-linked Counterparts. 2013.
Whelan SA, Tan E, Costello CE, Mccomb ME, Slawson C. Experimental Biology. Quantitative Proteomics to Profile Post-translational Modifications During M Phase: Interplay Between O-GlcNAcylation and Phosphorylation. FASEB J. Boston. 2013.

Bushkin GG, Motari E, Magnelli P, Gubbels MJ, Dubey JP, Miska KB, Bullitt E, Costello CE, Robbins PW, Samuelson J. ß-1,3-glucan, which can be targeted by drugs, forms a trabecular scaffold in the oocyst walls of Toxoplasma and Eimeria. MBio. 2012; 3(5).View Related Profiles.

Costello, Catherine
Motari, Edwin
Bullitt, Esther
Bushkin, Gary
Samuelson, John
Robbins, Phillips

PMID: 23015739; PMCID: PMC3518913; DOI: 10.1128/mBio.00258-12;

Chinnapen DJ, Hsieh WT, te Welscher YM, Saslowsky DE, Kaoutzani L, Brandsma E, D'Auria L, Park H, Wagner JS, Drake KR, Kang M, Benjamin T, Ullman MD, Costello CE, Kenworthy AK, Baumgart T, Massol RH, Lencer WI. Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1. Dev Cell. 2012 Sep 11; 23(3):573-86. PMID: 22975326; PMCID: PMC3443397; DOI: 10.1016/j.devcel.2012.08.002;

Yu X, Huang Y, Lin C, Costello CE. Energy-dependent electron activated dissociation of metal-adducted permethylated oligosaccharides. Anal Chem. 2012 Sep 4; 84(17):7487-94.View Related Profiles.

Costello, Catherine
Lin, Cheng
Huang, Yiqun

PMID: 22881449; PMCID: PMC3568493; DOI: 10.1021/ac301589z;

Lu Z, Madico G, Roche MI, Wang Q, Hui JH, Perkins HM, Zaia J, Costello CE, Sharon J. Protective B-cell epitopes of Francisella tularensis O-polysaccharide in a mouse model of respiratory tularaemia. Immunology. 2012 Jul; 136(3):352-60.View Related Profiles.

Costello, Catherine
Madico, Guillermo
Sharon, Jacqueline
Zaia, Joseph
Wang, Qi
Lu, Zhaohua

PMID: 22486311; PMCID: PMC3385035; DOI: 10.1111/j.1365-2567.2012.03589.x;

Li X, Yu X, Costello CE, Lin C, O'Connor PB. Top-down study of ß2-microglobulin deamidation. Anal Chem. 2012 Jul 17; 84(14):6150-7.View Related Profiles.

Costello, Catherine
Lin, Cheng

PMID: 22746280; PMCID: PMC4170183; DOI: 10.1021/ac3009324;

Mccomb ME, Whelan SA, Siwik DA, Colucci WS, Bachshmid MM, Cohen RA, Costello CE. The 11th HUPO World Congress. Biomarkers of Cardiovascular Disease related to Metabolic Syndrome and the American Diet. Boston. 2012.
Spencer JL, Bhatia VN, Kehasse A, Whelan SA, Heckendorf CF, Costello CE, Mccomb ME. The 11th HUPO World Congress. Characterization of Post-Translational Modifications Using Counting Approaches. Boston. 2012.
Whelan SA, Tan E, Costello CE, Mccomb ME, Slawson C. Experimental Biology. Quantitative proteomic analysis of proteins and post-translational modifications during the metaphase to anaphase transition after altered O-GlcNAcylation. FASEB J. San Diego. 2012; 26:978.5.
Whelan SA, Slawson C, Mccomb ME, Costello CE. The 11th HUPO World Congress. Quantitative Proteomic Analysis of Altered O-GlcNAcylation During the Metaphase to Anaphase Transition. Boston. 2012.
Han L, Costello CE. Joint Meeting of the Society-for-Glycobiology. Detailed structural investigation of beta-glucans from yeast cell walls by electron-transfer dissociation. 2012; 22.

Wang Q, Shi X, Leymarie N, Madico G, Sharon J, Costello CE, Zaia J. A typical preparation of Francisella tularensis O-antigen yields a mixture of three types of saccharides. Biochemistry. 2011 Dec 20; 50(50):10941-50.View Related Profiles.

Costello, Catherine
Madico, Guillermo
Sharon, Jacqueline
Zaia, Joseph
Leymarie, Nancy
Wang, Qi
Shi, Xiaofeng

PMID: 22091710; PMCID: PMC3238095; DOI: 10.1021/bi201450v;

Burgoyne JR, Haeussler DJ, Kumar V, Ji Y, Pimental DR, Zee RS, Costello CE, Lin C, McComb ME, Cohen RA, Bachschmid MM. Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis. FASEB J. 2012 Feb; 26(2):832-41.View Related Profiles.

Costello, Catherine
Lin, Cheng
Haeussler, Dagmar
Burgoyne, Joseph
McComb, Mark
Bachschmid, Markus
Cohen, Richard
Kumar, Vikas

PMID: 22085642; PMCID: PMC3290434; DOI: 10.1096/fj.11-189415;

Legrain P, Aebersold R, Archakov A, Bairoch A, Bala K, Beretta L, Bergeron J, Borchers CH, Corthals GL, Costello CE, Deutsch EW, Domon B, Hancock W, He F, Hochstrasser D, Marko-Varga G, Salekdeh GH, Sechi S, Snyder M, Srivastava S, Uhlén M, Wu CH, Yamamoto T, Paik YK, Omenn GS. The human proteome project: current state and future direction. Mol Cell Proteomics. 2011 Jul; 10(7):M111.009993. PMID: 21742803; PMCID: PMC3134076; DOI: 10.1074/mcp.M111.009993;

Legrain P, Aebersold R, Archakov A, Bairoch A, Bala K, Beretta L, Bergeron J, Borchers C, Corthals GL, Costello CE, Deutsch EW, Domon B, Hancock W, He F, Hochstrasser D, Marko-Varga G, Salekdeh GH, Sechi S, Snyder M, Srivastava S, Uhlen M, Hu CH, Yamamoto T, Paik YK, Omenn GS. The human proteome project: Current state and future direction. Mol Cell Proteomics. 2011 Apr 29. PMID: 21531903; DOI: 10.1074/mcp.O111.009993;

Han L, Costello CE. Electron transfer dissociation of milk oligosaccharides. J Am Soc Mass Spectrom. 2011 Jun; 22(6):997-1013. PMID: 21953041; PMCID: PMC3606914; DOI: 10.1007/s13361-011-0117-9;

Théberge R, Infusini G, Tong W, McComb ME, Costello CE. Top-Down Analysis of Small Plasma Proteins Using an LTQ-Orbitrap. Potential for Mass Spectrometry-Based Clinical Assays for Transthyretin and Hemoglobin. Int J Mass Spectrom. 2011 Mar 01; 300(2-3):130-142.View Related Profiles.

Costello, Catherine
McComb, Mark
Theberge, Roger

PMID: 21607198; PMCID: PMC3098445; DOI: 10.1016/j.ijms.2010.08.012;

Haeussler DJ, Kumar V, Burgoyne JR, Ji Y, Lin C, Costello CE, Pimental DR, Cohen RA, Bachschmid MM. Differential Labeling of Reversible Protein-Oxidation and S-Palmitoylation Using the Biotin-Switch Assay. Free Radical Biology and Medicine. 2011; 51. View Publication
Francoleon D, Ogorzalek Loo R, Loo R, Ytterberg AJ, Kim U, Gunsalus R, Costello CE. Annual Conference of the Society-for-Glycobiology. Methanosarcina mazei Sweet Uniqueness at its Cell Surface Protein Glycans. 2011; 21.
Han L, Costello CE. Annual Conference of the Society-for-Glycobiology. Structural Investigation of C-13 Labeled N-linked Glycans from Trichomonas vaginalis by Electron Transfer Dissociation. 2011.
Yu X, Lin C, Costello CE. Annual Conference of the Society-for-Glycobiology. Differentiation of Oligosaccharide Linkage Isomers by Electron Activated Dissociation. 2011.
Perreault H, Costello CE. Differentiation of cerebroside isomers and study of fragmentation by liquid secondary ion mass spectrometry and mass spectrometry/mass spectrometry of selected derivatives. Canadian Journal of Chemistry. 2011; 74(9):1682-1695. View Publication
Mao Y, Newburg DS, Costello CE, Zaia J. Annual Conference of the Society-for-Glycobiology. Comparative Glycomics of Human and Bovine Milk Glycosaminoglycans. 2011.
Hollingsworth MT, Costello CE, Hart GW, Paulson JC, Lebrilla C. Glycobiology. Program and abstracts for the 2011 Meeting of the Society for Glycobiology. 2011; 21(11):1454-531. View Publication
Burgoyne JR, Haeussler D, Ji Y, Bachschmid M, Costello CE et al. Oxidation of Terminal Cysteines On HRas during Metabolic Stress Prevents Palmitoylation and Contributes To Endothelial Dysfunction. Free Radical Biology and Medicine. 2011; 51. View Publication

Szmola R, Bence M, Carpentieri A, Szabó A, Costello CE, Samuelson J, Sahin-Tóth M. Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2. J Biol Chem. 2011 Jan 21; 286(3):1819-27.View Related Profiles.

Costello, Catherine
Samuelson, John
Sahin-Toth, Miklos

PMID: 21098023; PMCID: PMC3023477; DOI: 10.1074/jbc.M110.187369;

Seward RJ, Drouin EE, Steere AC, Costello CE. Peptides presented by HLA-DR molecules in synovia of patients with rheumatoid arthritis or antibiotic-refractory Lyme arthritis. Mol Cell Proteomics. 2011 Mar; 10(3):M110.002477. PMID: 21081667; PMCID: PMC3047150; DOI: 10.1074/mcp.M110.002477;

Zee RS, Yoo CB, Pimentel DR, Perlman DH, Burgoyne JR, Hou X, McComb ME, Costello CE, Cohen RA, Bachschmid MM. Redox regulation of sirtuin-1 by S-glutathiolation. Antioxid Redox Signal. 2010 Oct 1; 13(7):1023-32.View Related Profiles.

Costello, Catherine
Pimentel, David
Burgoyne, Joseph
McComb, Mark
Bachschmid, Markus
Cohen, Richard

PMID: 20392170; PMCID: PMC2959181; DOI: 10.1089/ars.2010.3251;

Ren R, Hong Z, Gong H, Laporte K, Skinner M, Seldin DC, Costello CE, Connors LH, Trinkaus-Randall V. Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils. J Biol Chem. 2010 Nov 26; 285(48):37672-82.View Related Profiles.

Costello, Catherine
Seldin, David
Gong, Haiyan
Connors, Lawreen
Skinner, Martha
Ren, Ruiyi
Trinkaus-Randall, Vickery
Hong, Zhenning

PMID: 20870723; PMCID: PMC2988372; DOI: 10.1074/jbc.M110.149575;

Carpentieri A, Ratner DM, Ghosh SK, Banerjee S, Bushkin GG, Cui J, Lubrano M, Steffen M, Costello CE, O'Keefe B, Robbins PW, Samuelson J. The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites. Eukaryot Cell. 2010 Nov; 9(11):1661-8.View Related Profiles.

Costello, Catherine
Bushkin, Gary
Samuelson, John
Steffen, Martin
Robbins, Phillips

PMID: 20852023; PMCID: PMC2976296; DOI: 10.1128/EC.00166-10;

Chatterjee A, Carpentieri A, Ratner DM, Bullitt E, Costello CE, Robbins PW, Samuelson J. Giardia cyst wall protein 1 is a lectin that binds to curled fibrils of the GalNAc homopolymer. PLoS Pathog. 2010; 6(8):e1001059.View Related Profiles.

Chatterjee, Aparajita
Costello, Catherine
Bullitt, Esther
Samuelson, John
Robbins, Phillips

PMID: 20808847; PMCID: PMC2924369; DOI: 10.1371/journal.ppat.1001059;

Palaima E, Leymarie N, Stroud D, Mizanur RM, Hodgkin J, Gravato-Nobre MJ, Costello CE, Cipollo JF. The Caenorhabditis elegans bus-2 mutant reveals a new class of O-glycans affecting bacterial resistance. J Biol Chem. 2010 Jun 4; 285(23):17662-72.View Related Profiles.

Costello, Catherine
Leymarie, Nancy

PMID: 20385555; PMCID: PMC2878530; DOI: 10.1074/jbc.M109.065433;

Li X, Lin C, Han L, Costello CE, O'Connor PB. Charge remote fragmentation in electron capture and electron transfer dissociation. J Am Soc Mass Spectrom. 2010 Apr; 21(4):646-56.View Related Profiles.

Costello, Catherine
Lin, Cheng

PMID: 20171118; PMCID: PMC2882803; DOI: 10.1016/j.jasms.2010.01.001;

Staples GO, Naimy H, Yin H, Kileen K, Kraiczek K, Costello CE, Zaia J. Improved hydrophilic interaction chromatography LC/MS of heparinoids using a chip with postcolumn makeup flow. Anal Chem. 2010 Jan 15; 82(2):516-22.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 20000724; PMCID: PMC3247906; DOI: 10.1021/ac901706f;

Ebbel EN, Leymarie N, Schiavo S, Sharma S, Gevorkian S, Hersch S, Matson WR, Costello CE. Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry. Anal Biochem. 2010 Apr 15; 399(2):152-61.View Related Profiles.

Costello, Catherine
Leymarie, Nancy

PMID: 20074541; PMCID: PMC3568495; DOI: 10.1016/j.ab.2010.01.010;

Liu J, Ortega F, Sethuraman P, Katsoulis DE, Costello CE, Pope MT. ChemInform Abstract: Trimetallo Derivatives of Lacunary 9-Tungstosilicate Heteropolyanions. Part 1. Synthesis and Characterization. ChemInform. 2010; 23(39):37. View Publication
Naimy H, Staples G, Mccomb ME, Costello CE, Zaia J, Leymarie N. Patterns of Tissue-Specific Glycosaminoglycan Expression Revealed by Tandem Mass Spectrometry and Statistical Methods. Journal of biomolecular techniques: JBT. 2010; 21(3 Suppl).
Smook ME, Widstrom NW, Wiseman BR, Gueldner RC, Wilson RL, Himmelsbach DS, Harwood J, Costello CE. ChemInform Abstract: New Flavone C-Glycosides from Corn (Zea mays L.) for the Control of the Corn Earworm (Helicoverpa zea). ChemInform. 2010; 25(42). View Publication
Han L, Costello CE. Investigations of Structures and Fragmentation Pathways by Electron Transfer Dissociation of Permethylated Milk Sugars. Glycobiology. 2010; 20:1514-1515.
Yu X, Lin C, Costello CE. Annual Conference of the Society-for-Glycobiology. Electron Energy Dependent Electron Capture Dissociation, an Informative Tool for Structural Characterization of Oligosaccharides. 2010; 20.

Wada Y, Dell A, Haslam SM, Tissot B, Canis K, Azadi P, Bäckström M, Costello CE, Hansson GC, Hiki Y, Ishihara M, Ito H, Kakehi K, Karlsson N, Hayes CE, Kato K, Kawasaki N, Khoo KH, Kobayashi K, Kolarich D, Kondo A, Lebrilla C, Nakano M, Narimatsu H, Novak J, Novotny MV, Ohno E, Packer NH, Palaima E, Renfrow MB, Tajiri M, Thomsson KA, Yagi H, Yu SY, Taniguchi N. Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1. Mol Cell Proteomics. 2010 Apr; 9(4):719-27. PMID: 20038609; PMCID: PMC2860227; DOI: 10.1074/mcp.M900450-MCP200;

Ying W, Perlman DH, Li L, Théberge R, Costello CE, McComb ME. Highly efficient and selective enrichment of peptide subsets combining fluorous chemistry with reversed-phase chromatography. Rapid Commun Mass Spectrom. 2009 Dec; 23(24):4019-30.View Related Profiles.

Costello, Catherine
McComb, Mark
Theberge, Roger

PMID: 19924777; PMCID: PMC3584324; DOI: 10.1002/rcm.4343;

Bhatia VN, Perlman DH, Costello CE, McComb ME. Software tool for researching annotations of proteins: open-source protein annotation software with data visualization. Anal Chem. 2009 Dec 1; 81(23):9819-23.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 19839595; PMCID: PMC2787672; DOI: 10.1021/ac901335x;

Connors LH, Prokaeva T, Lim A, Théberge R, Falk RH, Doros G, Berg A, Costello CE, O'Hara C, Seldin DC, Skinner M. Cardiac amyloidosis in African Americans: comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosis. Am Heart J. 2009 Oct; 158(4):607-14.View Related Profiles.

O'Hara, Carl
Costello, Catherine
Seldin, David
Doros, Gheorghe
Connors, Lawreen
Skinner, Martha
Theberge, Roger
Prokaeva, Tatiana

PMID: 19781421; DOI: 10.1016/j.ahj.2009.08.006;

Young DC, Kasmar A, Moraski G, Cheng TY, Walz AJ, Hu J, Xu Y, Endres GW, Uzieblo A, Zajonc D, Costello CE, Miller MJ, Moody DB. Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures. J Biol Chem. 2009 Sep 11; 284(37):25087-96. PMID: 19605355; PMCID: PMC2757212; DOI: 10.1074/jbc.M109.000802;

Rex S, Beaulieu LM, Perlman DH, Vitseva O, Blair PS, McComb ME, Costello CE, Freedman JE. Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release. Thromb Haemost. 2009 Jul; 102(1):97-110.View Related Profiles.

Costello, Catherine
Freedman, Jane
Beaulieu, Lea
McComb, Mark
Vitseva, Olga

PMID: 19572074; PMCID: PMC2774228; DOI: 10.1160/TH08-08-0513;

Romesser PB, Perlman DH, Faller DV, Costello CE, McComb ME, Denis GV. Development of a malignancy-associated proteomic signature for diffuse large B-cell lymphoma. Am J Pathol. 2009 Jul; 175(1):25-35.View Related Profiles.

Costello, Catherine
Faller, Douglas
Denis, Gerald
McComb, Mark

PMID: 19498000; PMCID: PMC2708791; DOI: 10.2353/ajpath.2009.080707;

Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, Barral D, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB. CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J Exp Med. 2009 Jun 8; 206(6):1409-22. PMID: 19468063; PMCID: PMC2715062; DOI: 10.1084/jem.20082480;

Makkinje A, Near RI, Infusini G, Vanden Borre P, Bloom A, Cai D, Costello CE, Lerner A. AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. Cell Signal. 2009 Sep; 21(9):1423-35.View Related Profiles.

Lerner, Adam
Costello, Catherine
Near, Richard

PMID: 19454314; PMCID: PMC2740797; DOI: 10.1016/j.cellsig.2009.05.006;

Jones KL, Seward RJ, Ben-Menachem G, Glickstein LJ, Costello CE, Steere AC. Strong IgG antibody responses to Borrelia burgdorferi glycolipids in patients with Lyme arthritis, a late manifestation of the infection. Clin Immunol. 2009 Jul; 132(1):93-102. PMID: 19342303; PMCID: PMC2752957; DOI: 10.1016/j.clim.2009.03.510;

Perlman DH, Bauer SM, Ashrafian H, Bryan NS, Garcia-Saura MF, Lim CC, Fernandez BO, Infusini G, McComb ME, Costello CE, Feelisch M. Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach. Circ Res. 2009 Mar 27; 104(6):796-804.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 19229060; PMCID: PMC6731772; DOI: 10.1161/CIRCRESAHA.108.187005;

Staples GO, Bowman MJ, Costello CE, Hitchcock AM, Lau JM, Leymarie N, Miller C, Naimy H, Shi X, Zaia J. A chip-based amide-HILIC LC/MS platform for glycosaminoglycan glycomics profiling. Proteomics. 2009 Feb; 9(3):686-95.View Related Profiles.

Costello, Catherine
Zaia, Joseph
Leymarie, Nancy
Shi, Xiaofeng

PMID: 19137549; PMCID: PMC2771417; DOI: 10.1002/pmic.200701008;

Drouin EE, Seward R, Costello CE, Steere A. S.71. HLA-DRB1-Presented Peptides in Inflamed Synovium from Patients with Rheumatoid Arthritis or Antibiotic-Refractory Lyme Arthritis. Clinical Immunology. 2009; 131. View Publication

Wang Y, Meriin AB, Zaarur N, Romanova NV, Chernoff YO, Costello CE, Sherman MY. Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery. FASEB J. 2009 Feb; 23(2):451-63.View Related Profiles.

Meriin, Anatoli
Costello, Catherine
Sherman, Michael
Zaarur, Nava

PMID: 18854435; PMCID: PMC2630789; DOI: 10.1096/fj.08-117614;

Pfenninger A, Chan SY, Karas M, Finke B, Stahl B, Costello CE. Mass spectrometric detection of multiple extended series of neutral highly fucosylated N-acetyllactosamine oligosaccharides in human milk. Int J Mass Spectrom. 2008 Dec 01; 278(2-3):129-136. PMID: 23538872; PMCID: PMC3607386; DOI: 10.1016/j.ijms.2008.09.005;

Kilcoyne M, Shah M, Gerlach JQ, Bhavanandan V, Nagaraj V, Smith AD, Fujiyama K, Sommer U, Costello CE, Olszewski N, Joshi L. O-glycosylation of protein subpopulations in alcohol-extracted rice proteins. J Plant Physiol. 2009 Feb 15; 166(3):219-32. PMID: 18639953; DOI: 10.1016/j.jplph.2008.05.007;

Singh BN, Hayes GR, Lucas JJ, Sommer U, Viseux N, Mirgorodskaya E, Trifonova RT, Sassi RR, Costello CE, Fichorova RN. Structural details and composition of Trichomonas vaginalis lipophosphoglycan in relevance to the epithelial immune function. Glycoconj J. 2009 Jan; 26(1):3-17. PMID: 18604640; PMCID: PMC2637367; DOI: 10.1007/s10719-008-9157-1;

Lavatelli F, Perlman DH, Spencer B, Prokaeva T, McComb ME, Théberge R, Connors LH, Bellotti V, Seldin DC, Merlini G, Skinner M, Costello CE. Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue. Mol Cell Proteomics. 2008 Aug; 7(8):1570-83.View Related Profiles.

Costello, Catherine
Seldin, David
Connors, Lawreen
McComb, Mark
Skinner, Martha
Theberge, Roger
Prokaeva, Tatiana

PMID: 18474516; PMCID: PMC2494907; DOI: 10.1074/mcp.M700545-MCP200;

Magnelli P, Cipollo JF, Ratner DM, Cui J, Kelleher D, Gilmore R, Costello CE, Robbins PW, Samuelson J. Unique Asn-linked oligosaccharides of the human pathogen Entamoeba histolytica. J Biol Chem. 2008 Jun 27; 283(26):18355-64.View Related Profiles.

Costello, Catherine
Samuelson, John
Robbins, Phillips

PMID: 18417475; PMCID: PMC2440624; DOI: 10.1074/jbc.M800725200;

Hitchcock AM, Yates KE, Costello CE, Zaia J. Comparative glycomics of connective tissue glycosaminoglycans. Proteomics. 2008 Apr; 8(7):1384-97.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 18318007; PMCID: PMC2577024; DOI: 10.1002/pmic.200700787;

Kingsbury JS, Laue TM, Klimtchuk ES, Théberge R, Costello CE, Connors LH. The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation. J Biol Chem. 2008 May 2; 283(18):11887-96.View Related Profiles.

Costello, Catherine
Klimtchuk, Elena
Connors, Lawreen
Theberge, Roger

PMID: 18326041; PMCID: PMC2335343; DOI: 10.1074/jbc.M709638200;

Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A. Human Proteinpedia enables sharing of human protein data. Nat Biotechnol. 2008 Feb; 26(2):164-7.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 18259167; DOI: 10.1038/nbt0208-164;

Lim CC, Yang H, Yang M, Wang CK, Shi J, Berg EA, Pimentel DR, Gwathmey JK, Hajjar RJ, Helmes M, Costello CE, Huo S, Liao R. A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility. Biophys J. 2008 May 1; 94(9):3577-89.View Related Profiles.

Costello, Catherine
Pimentel, David

PMID: 18212018; PMCID: PMC2292379; DOI: 10.1529/biophysj.107.112896;

Brennan MR, Costello CE, Maleknia SD, Pettit GR, Erickson KL. Stylopeptide 2, a proline-rich cyclodecapeptide from the sponge Stylotella sp. J Nat Prod. 2008 Mar; 71(3):453-6. PMID: 18197605; DOI: 10.1021/np0704856;

Staples G, Costello CE, Zaia J. Annual Meeting of the Society-for-Glycobiology. Structural Analysis of Sulf2 Activity on Heparan Sulfate Domains. 2008.
Xie B, Costello CE. Carbohydrate Chemistry, Biology and Medical Applications. Carbohydrate Structure Determination by Mass Spectrometry. 2008; 29-57. View Publication
Blackmom Ross KE, Nita-Lazar M, Kukuruzinska MA, Costello CE. Annual Meeting of the Society-for-Glycobiology. N-Glycosylation of E-Cadherin Affects Protein Complex Formation. 2008.

Xie B, Luo X, Zhao C, Priest CM, Chan SY, O' Connor PB, Kirschner DA, Costello CE. Molecular Characterization of Myelin Protein Zero in Xenopus laevis Peripheral Nerve: Equilibrium between Non-covalently Associated Dimer and Monomer. Int J Mass Spectrom. 2007 Dec 01; 268(2-3):304-315. PMID: 19430539; PMCID: PMC2678737; DOI: 10.1016/j.ijms.2007.08.007;

Connors LH, Jiang Y, Budnik M, Théberge R, Prokaeva T, Bodi KL, Seldin DC, Costello CE, Skinner M. Heterogeneity in primary structure, post-translational modifications, and germline gene usage of nine full-length amyloidogenic kappa1 immunoglobulin light chains. Biochemistry. 2007 Dec 11; 46(49):14259-71.View Related Profiles.

Costello, Catherine
Seldin, David
Connors, Lawreen
Skinner, Martha
Theberge, Roger
Prokaeva, Tatiana

PMID: 18004879; PMCID: PMC2912213; DOI: 10.1021/bi7013773;

Zhao C, Xie B, Chan SY, Costello CE, O'Connor PB. Collisionally activated dissociation and electron capture dissociation provide complementary structural information for branched permethylated oligosaccharides. J Am Soc Mass Spectrom. 2008 Jan; 19(1):138-50. PMID: 18063385

Luo X, Cerullo J, Dawli T, Priest C, Haddadin Z, Kim A, Inouye H, Suffoletto BP, Avila RL, Lees JP, Sharma D, Xie B, Costello CE, Kirschner DA. Peripheral myelin of Xenopus laevis: role of electrostatic and hydrophobic interactions in membrane compaction. J Struct Biol. 2008 Apr; 162(1):170-83. PMID: 18065238; PMCID: PMC2435285; DOI: 10.1016/j.jsb.2007.10.012;

Costello CE, Contado-Miller JM, Cipollo JF. A glycomics platform for the analysis of permethylated oligosaccharide alditols. J Am Soc Mass Spectrom. 2007 Oct; 18(10):1799-812. PMID: 17719235; PMCID: PMC4383468; DOI: 10.1016/j.jasms.2007.07.016;

Altland K, Benson MD, Costello CE, Ferlini A, Hazenberg BP, Hund E, Kristen AV, Linke RP, Merlini G, Salvi F, Saraiva MJ, Singer R, Skinner M, Winter P. Genetic microheterogeneity of human transthyretin detected by IEF. Electrophoresis. 2007 Jun; 28(12):2053-64.View Related Profiles.

Costello, Catherine
Skinner, Martha

PMID: 17503405

Pilch PF, Souto RP, Liu L, Jedrychowski MP, Berg EA, Costello CE, Gygi SP. Cellular spelunking: exploring adipocyte caveolae. J Lipid Res. 2007 Oct; 48(10):2103-11.View Related Profiles.

Costello, Catherine
Liu, Libin
Pilch, Paul

PMID: 17496267

Saba JA, McComb ME, Potts DL, Costello CE, Amar S. Proteomic mapping of stimulus-specific signaling pathways involved in THP-1 cells exposed to Porphyromonas gingivalis or its purified components. J Proteome Res. 2007 Jun; 6(6):2211-21.View Related Profiles.

Costello, Catherine
McComb, Mark
Amar, Salomon

PMID: 17477557; PMCID: PMC3925766; DOI: 10.1021/pr070031u;

Wang Y, Meriin AB, Costello CE, Sherman MY. Characterization of proteins associated with polyglutamine aggregates: a novel approach towards isolation of aggregates from protein conformation disorders. Prion. 2007 Apr-Jun; 1(2):128-35.View Related Profiles.

Meriin, Anatoli
Costello, Catherine
Sherman, Michael

PMID: 19164926; PMCID: PMC2634453; DOI: 10.4161/pri.1.2.4440;

Zaia J, Miller MJ, Seymour JL, Costello CE. The role of mobile protons in negative ion CID of oligosaccharides. J Am Soc Mass Spectrom. 2007 May; 18(5):952-60.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 17383193; PMCID: PMC1964798; DOI: 10.1016/j.jasms.2007.01.016;

Rosenzweig M, Skinner M, Prokaeva T, Théberge R, Costello C, Drachman BM, Connors LH. A new transthyretin variant (Glu61Gly) associated with cardiomyopathy. Amyloid. 2007 Mar; 14(1):65-71.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Skinner, Martha
Theberge, Roger
Prokaeva, Tatiana

PMID: 17453626

Kranz C, Ng BG, Sun L, Sharma V, Eklund EA, Miura Y, Ungar D, Lupashin V, Winkel RD, Cipollo JF, Costello CE, Loh E, Hong W, Freeze HH. COG8 deficiency causes new congenital disorder of glycosylation type IIh. Hum Mol Genet. 2007 Apr 1; 16(7):731-41. PMID: 17331980

Kingsbury JS, Théberge R, Karbassi JA, Lim A, Costello CE, Connors LH. Detailed structural analysis of amyloidogenic wild-type transthyretin using a novel purification strategy and mass spectrometry. Anal Chem. 2007 Mar 1; 79(5):1990-8.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Theberge, Roger

PMID: 17261023

Perlman DH, Huang H, Dauly C, Costello CE, McComb ME. Coupling of protein HPLC to MALDI-TOF MS using an on-target device for fraction collection, concentration, digestion, desalting, and matrix/analyte cocrystallization. Anal Chem. 2007 Mar 1; 79(5):2058-66.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 17256876

Kingsbury JS, Klimtchuk ES, Théberge R, Costello CE, Connors LH. Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretin. Protein Expr Purif. 2007 Jun; 53(2):370-7.View Related Profiles.

Costello, Catherine
Klimtchuk, Elena
Connors, Lawreen
Theberge, Roger

PMID: 17317215; PMCID: PMC2696000; DOI: 10.1016/j.pep.2007.01.004;

Wada Y, Azadi P, Costello CE, Dell A, Dwek RA, Geyer H, Geyer R, Kakehi K, Karlsson NG, Kato K, Kawasaki N, Khoo KH, Kim S, Kondo A, Lattova E, Mechref Y, Miyoshi E, Nakamura K, Narimatsu H, Novotny MV, Packer NH, Perreault H, Peter-Katalinic J, Pohlentz G, Reinhold VN, Rudd PM, Suzuki A, Taniguchi N. Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study. Glycobiology. 2007 Apr; 17(4):411-22. PMID: 17223647

Odhiambo A, Perlman DH, Huang H, Costello CE, Farber HW, Steinberg MH, McComb ME, Klings ES. Identification of oxidative post-translational modification of serum albumin in patients with idiopathic pulmonary arterial hypertension and pulmonary hypertension of sickle cell anemia. Rapid Commun Mass Spectrom. 2007; 21(14):2195-203.View Related Profiles.

Costello, Catherine
Klings, Elizabeth
Farber, Harrison
McComb, Mark
Steinberg, Martin

PMID: 17569101

McComb ME, Perlman DH, Huang H, Costello CE. Evaluation of an on-target sample preparation system for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in conjunction with normal-flow peptide high-performance liquid chromatography for peptide mass fingerprint analyses. Rapid Commun Mass Spectrom. 2007; 21(1):44-58.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 17133622

Sethuraman M, Clavreul N, Huang H, McComb ME, Costello CE, Cohen RA. Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry. Free Radic Biol Med. 2007 Mar 15; 42(6):823-9.View Related Profiles.

Costello, Catherine
McComb, Mark
Cohen, Richard

PMID: 17320764; PMCID: PMC1855198; DOI: 10.1016/j.freeradbiomed.2006.12.012;

Monis GF, Schultz C, Ren R, Eberhard J, Costello C, Connors L, Skinner M, Trinkaus-Randall V. Role of endocytic inhibitory drugs on internalization of amyloidogenic light chains by cardiac fibroblasts. Am J Pathol. 2006 Dec; 169(6):1939-52.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Skinner, Martha
Ren, Ruiyi
Trinkaus-Randall, Vickery

PMID: 17148659; PMCID: PMC1762491; DOI: 10.2353/ajpath.2006.060183;

Fichorova RN, Trifonova RT, Gilbert RO, Costello CE, Hayes GR, Lucas JJ, Singh BN. Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells. Infect Immun. 2006 Oct; 74(10):5773-9. PMID: 16988255; PMCID: PMC1594934; DOI: 10.1128/IAI.00631-06;

Hitchcock AM, Yates KE, Shortkroff S, Costello CE, Zaia J. Optimized extraction of glycosaminoglycans from normal and osteoarthritic cartilage for glycomics profiling. Glycobiology. 2007 Jan; 17(1):25-35.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 16980326; PMCID: PMC2630472; DOI: 10.1093/glycob/cwl046;

Mitsi M, Hong Z, Costello CE, Nugent MA. Heparin-mediated conformational changes in fibronectin expose vascular endothelial growth factor binding sites. Biochemistry. 2006 Aug 29; 45(34):10319-28.View Related Profiles.

Costello, Catherine
Nugent, Matthew
Hong, Zhenning

PMID: 16922507

Ghosh S, Seward R, Costello CE, Stollar BD, Huber BT. Autoantibodies from synovial lesions in chronic, antibiotic treatment-resistant Lyme arthritis bind cytokeratin-10. J Immunol. 2006 Aug 15; 177(4):2486-94. PMID: 16888010

Madico G, Welsch JA, Lewis LA, McNaughton A, Perlman DH, Costello CE, Ngampasutadol J, Vogel U, Granoff DM, Ram S. The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance. J Immunol. 2006 Jul 1; 177(1):501-10.View Related Profiles.

Costello, Catherine
Madico, Guillermo

PMID: 16785547; PMCID: PMC2248442; DOI: 10.4049/jimmunol.177.1.501;

Dauly C, Perlman DH, Costello CE, McComb ME. Protein separation and characterization by np-RP-HPLC followed by intact MALDI-TOF mass spectrometry and peptide mass mapping analyses. J Proteome Res. 2006 Jul; 5(7):1688-700.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 16823977; PMCID: PMC2590652; DOI: 10.1021/pr060108z;

Seymour JL, Costello CE, Zaia J. The influence of sialylation on glycan negative ion dissociation and energetics. J Am Soc Mass Spectrom. 2006 Jun; 17(6):844-54.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 16603372; PMCID: PMC2586975; DOI: 10.1016/j.jasms.2006.02.022;

Xie B, Zhou G, Chan SY, Shapiro E, Kong XP, Wu XR, Sun TT, Costello CE. Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia. J Biol Chem. 2006 May 26; 281(21):14644-53. PMID: 16567801

Denis GV, McComb ME, Faller DV, Sinha A, Romesser PB, Costello CE. Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. J Proteome Res. 2006 Mar; 5(3):502-11.View Related Profiles.

Costello, Catherine
Faller, Douglas
Denis, Gerald
McComb, Mark

PMID: 16512664; PMCID: PMC2823066; DOI: 10.1021/pr050430u;

Hitchcock AM, Costello CE, Zaia J. Glycoform quantification of chondroitin/dermatan sulfate using a liquid chromatography-tandem mass spectrometry platform. Biochemistry. 2006 Feb 21; 45(7):2350-61.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 16475824; PMCID: PMC2597419; DOI: 10.1021/bi052100t;

Miller MJ, Costello CE, Malmström A, Zaia J. A tandem mass spectrometric approach to determination of chondroitin/dermatan sulfate oligosaccharide glycoforms. Glycobiology. 2006 Jun; 16(6):502-13.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 16489125; PMCID: PMC2577607; DOI: 10.1093/glycob/cwj093;

Sommer U, Herscovitz H, Welty FK, Costello CE. LC-MS-based method for the qualitative and quantitative analysis of complex lipid mixtures. J Lipid Res. 2006 Apr; 47(4):804-14.View Related Profiles.

Costello, Catherine
Herscovitz, Haya

PMID: 16443931

Zaia J, Campuzano I, Giles K, Bateman R, Keith C, Costello CE. Meeting of the Society-for-Gylcobiology. Electrospray ion mobility spectrometry of isomeric carbohydrates. Glycobiology. 2006; 16.
Singh BN, Lucas JL, Hayes GR, Sommer U, Costello CE, Fichorova R. Meeting of the Society-for-Gylcobiology. Structure and biological significance of Trichomonas vaginalis LPG. Glycobiology. 2006; 16.
Hong Z, Theberge R, Connors LH, Skinner M, Costello CE. 11th International Symposium on Amyloidosis. Detection and characterization of immunoglobulin light chain fibrils from different organs of a single AL patient. 2006; 13.
Prokaeva T, Spencer B, Doros G, Eberhard J, Jiang Y, Budnik M, Theberge R, Costello CE, Connors LH, Skinner M, Seldin DC. 11th International Symposium on Amyloidosis. Somatic mutations create potential N-glycosylation sites in the immunoglobulin light chain variable regions (VL) in primary amyloidosis (AL). Amyloid. 2006; 13. View Publication
Ren R, Hong Z, Gantz D, Connors L, Skinner M, Costello CE, Trinkaus-Randall V. 11th International Symposium on Amyloidosis. Fibril formation is mediated by sulfated glycosaminoglycans. Amyloid. 2006; 13.
Lavatelli F, Perlman DH, Mccomb ME, Theberge R, Seldin DC, Connors LH, Merlini G, Skinner M, Costello CE. 11th International Symposium on Amyloidosis. A Proteomic Approach to the Study of Systemic Amyloidoses. Amyloid. 2006; 13. View Publication
Costello CE, Theberge R, Kingsbury J, Klimtchuk ES, Connors LH, Skinner M, O'Connor P, Chen L. 11th International Symposium on Amyloidosis. Top-down Mass Spectrometry Analysis of Amyloidogenic Proteins. Amyloid. 2006; 13. View Publication
Jiang Y, Theberge R, Eberhard J, Karamitis G, Prokaeva T, Connors LH, Skinner M, Lin C, O'Connor P, Costello CE. 11th International Symposium on Amyloidosis. Characterization of post-translational modifications of an amyloidogenic immunoglobulin kappa light chain. Amyloid. 2006; 13. View Publication
Rex S, Perlman DH, Vitseva O, Blair PS, Mccomb ME, Costello CE, Freedman JE. 79th Annual Scientific Session of the American-Heart-Association. Immune vs. thrombotic stimulation of platelets differentially regulates intracellular protein associations and protein, release: a proteomics analysis. Circulation. 2006; 14.
Hitchcock AM, Costello CE, Zaia J. Meeting of the Society-for-Gylcobiology. Comparative glycomics of connective tissue glycosaminoglycans using mass spectrometry. 2006; 16.
Ivleva VB, Wolf AA, Lencer WI, Chinnapen F, O'Connor P, Costello CE. Structural characterization of glycosphingolipids and toxin receptor gangliosides by IRMPD with TLC/VC-MALDI-FTMS. Glycobiology. 2006.
Xie B, Luo X, Zhao C, Priest C, Chan SY, O'Connor P, Kirschner DA, Costello CE. Meeting of the Society-for-Gylcobiology. Molecular basis for equilibrium between non-covalent dimer and monomer of myelin P0 glycoprotein in Xenopus laevis peripheral nerve. Glycobiology. 2006; 16.
Kilcoyne M, Shah M, Gerlach JQ, Smith A, Fujiyama K, Bhavanandan V, Summers U, Costello CE, Joshi L. Meeting of the Society-for-Gylcobiology. Mucin-type O-glycosylation and O-GlcNAc found in rice seed storage protein prolamin fraction. 2006; 16.
Kingsbury JS, Theberge R, Costello CE, Connors LH. 11th International Symposium on Amyloidosis. Mass spectrometric characterization of wild type Cys10 crosslinked transthyretin in ex vivo cardiac deposits from cases of senile systemic amyloidosis. 2006; 13.
Connors LH, Eberhard J, Spencer B, Prokaeva T, Seldin D, Jiang YY, Budnik M, Theberge R, Costello CE, Skinner M. 11th International Symposium on Amyloidosis. Comparison of Immunoglobulin Light Chains (K1): Amyloidogenic Vs. Nonamyloidogenic Proteins. Amyloid. 2006; 13. View Publication

Wang Y, Berg EA, Feng X, Shen L, Smith T, Costello CE, Zhang YX. Identification of surface-exposed components of MOMP of Chlamydia trachomatis serovar F. Protein Sci. 2006 Jan; 15(1):122-34. PMID: 16322562; PMCID: PMC2242375; DOI: 10.1110/ps.051616206;

Jebanathirajah JA, Pittman JL, Thomson BA, Budnik BA, Kaur P, Rape M, Kirschner M, Costello CE, O'Connor PB. Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins. J Am Soc Mass Spectrom. 2005 Dec; 16(12):1985-99. PMID: 16271296

Oh SY, Ellenstein A, Chen CD, Hinman JD, Berg EA, Costello CE, Yamin R, Neve RL, Abraham CR. Amyloid precursor protein interacts with notch receptors. J Neurosci Res. 2005 Oct 1; 82(1):32-42.View Related Profiles.

Abraham, Carmela
Costello, Catherine
Chen, Ci-Di
Oh, Sunyoung

PMID: 16118793

Ivleva VB, Sapp LM, O'Connor PB, Costello CE. Ganglioside analysis by thin-layer chromatography matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry. J Am Soc Mass Spectrom. 2005 Sep; 16(9):1552-60. PMID: 16054389

Perlman DH, Berg EA, O'connor PB, Costello CE, Hu J. Reverse transcription-associated dephosphorylation of hepadnavirus nucleocapsids. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):9020-5. PMID: 15951426; PMCID: PMC1157036; DOI: 10.1073/pnas.0502138102;

Cipollo JF, Awad AM, Costello CE, Hirschberg CB. N-Glycans of Caenorhabditis elegans are specific to developmental stages. J Biol Chem. 2005 Jul 15; 280(28):26063-72.View Related Profiles.

Hirschberg, Carlos
Costello, Catherine

PMID: 15899899

Sommer U, Costello CE, Hayes GR, Beach DH, Gilbert RO, Lucas JJ, Singh BN. Identification of Trichomonas vaginalis cysteine proteases that induce apoptosis in human vaginal epithelial cells. J Biol Chem. 2005 Jun 24; 280(25):23853-60. PMID: 15843376

Chung CM, Chiu JD, Connors LH, Gursky O, Lim A, Dykstra AB, Liepnieks J, Benson MD, Costello CE, Skinner M, Walsh MT. Thermodynamic stability of a kappaI immunoglobulin light chain: relevance to multiple myeloma. Biophys J. 2005 Jun; 88(6):4232-42.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Skinner, Martha
Gursky, Olga

PMID: 15792972; PMCID: PMC1305653; DOI: 10.1529/biophysj.105.061317;

Zajonc DM, Crispin MD, Bowden TA, Young DC, Cheng TY, Hu J, Costello CE, Rudd PM, Dwek RA, Miller MJ, Brenner MB, Moody DB, Wilson IA. Molecular mechanism of lipopeptide presentation by CD1a. Immunity. 2005 Feb; 22(2):209-19. PMID: 15723809

Cournoyer JJ, Pittman JL, Ivleva VB, Fallows E, Waskell L, Costello CE, O'Connor PB. Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation. Protein Sci. 2005 Feb; 14(2):452-63. PMID: 15659375; PMCID: PMC2253403; DOI: 10.1110/ps.041062905;

Ivleva VB, Wolf AA, Lencer WI, O'Connor PB, Costello CE. Meeting of the Society-for-Glycobiology. Structural characterization of toxin-binding gangliosides by TLC/VC-FTMS. Glycobiology. 2005.
Rex S, Blair PS, Perlman DH, Huang H, Mccomb ME, Costello CE, Freedman JE. 78th Annual Scientific Session of the American-Heart-Association. Proteomics analysis of toll-like receptor 2 and intracellular factor XIIIA in platelets: Functional implications in immune defense. Circulation. 2005; 112.
Staples G, Hodgkin J, Zaia O, Costello CE, Cipollo JF. Meeting of the Society-for-Glycobiology. Microbacterium nematophilum infection of the Caenorhabditis elegans cuticle requires galactosyl oligosaccharides. Glycobiology. 2005; 15.
Zaia J, Seymour JL, Costello CE. Meeting of the Society-for-Glycobiology. Glycomics using negative ion tandem mass spectrometry of native glycans. Glycobiology. 2005; 15.
Sommer U, Costello CE. Meeting of the Society-for-Glycobiology. A new tandem LC-MS-based method for glycolipids. Glycobiology. 2005; 15.
Singh BN, Lucas JJ, Hayes GR, Kummer S, Gilbert R, Sommer U, Costello CE. Identification and cloning of Trichomonas vaginalis cysteine proteases that induce human vaginal epithelial cell (HVEC) apoptosis. The FASEB Journal. 2005; 19:A836.
Xie B, Lu XY, Kirschner DA, Costello CE. Meeting of the Society-for-Glycobiology. Mass spectrometry structural investigation to address stability of ghleoprotein P0 dimer. Glycobiology. 2005; 15.
Xie B, Zhou G, Chan SY, Sun TT, Costello CE. Meeting of the Society-for-Glycobiology. Mass spectrometry strategy for the determination of N-glycosylation patterns in uroplakins. 2005; 15.
Hitchcock AM, Costello CE, Zaia J. Meeting of the Society-for-Glycobiology. An LC/MS/MS platform for glycoform quantification of chondroitin sulfate. Glycobiology. 2005; 15.

Matsunaga I, Bhatt A, Young DC, Cheng TY, Eyles SJ, Besra GS, Briken V, Porcelli SA, Costello CE, Jacobs WR, Moody DB. Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. J Exp Med. 2004 Dec 20; 200(12):1559-69. PMID: 15611286; PMCID: PMC2211992

Gudiksen KL, Urbach AR, Gitlin I, Yang J, Vazquez JA, Costello CE, Whitesides GM. Influence of the Zn(II) cofactor on the refolding of bovine carbonic anhydrase after denaturation with sodium dodecyl sulfate. Anal Chem. 2004 Dec 15; 76(24):7151-61. PMID: 15595855

Pedrioli PG, Eng JK, Hubley R, Vogelzang M, Deutsch EW, Raught B, Pratt B, Nilsson E, Angeletti RH, Apweiler R, Cheung K, Costello CE, Hermjakob H, Huang S, Julian RK, Kapp E, McComb ME, Oliver SG, Omenn G, Paton NW, Simpson R, Smith R, Taylor CF, Zhu W, Aebersold R. A common open representation of mass spectrometry data and its application to proteomics research. Nat Biotechnol. 2004 Nov; 22(11):1459-66.View Related Profiles.

Costello, Catherine
McComb, Mark

PMID: 15529173

Sethuraman M, McComb ME, Huang H, Huang S, Heibeck T, Costello CE, Cohen RA. Isotope-coded affinity tag (ICAT) approach to redox proteomics: identification and quantitation of oxidant-sensitive cysteine thiols in complex protein mixtures. J Proteome Res. 2004 Nov-Dec; 3(6):1228-33.View Related Profiles.

Costello, Catherine
McComb, Mark
Cohen, Richard

PMID: 15595732

Ivleva VB, Elkin YN, Budnik BA, Moyer SC, O'Connor PB, Costello CE. Coupling thin-layer chromatography with vibrational cooling matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for the analysis of ganglioside mixtures. Anal Chem. 2004 Nov 1; 76(21):6484-91. PMID: 15516145

Naggar EF, Costello CE, Zaia J. Competing fragmentation processes in tandem mass spectra of heparin-like glycosaminoglycans. J Am Soc Mass Spectrom. 2004 Nov; 15(11):1534-44.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 15519220

Cipollo JF, Awad AM, Costello CE, Hirschberg CB. srf-3, a mutant of Caenorhabditis elegans, resistant to bacterial infection and to biofilm binding, is deficient in glycoconjugates. J Biol Chem. 2004 Dec 17; 279(51):52893-903.View Related Profiles.

Hirschberg, Carlos
Costello, Catherine

PMID: 15452127

Singh BN, Lucas JJ, Hayes GR, Kumar I, Beach DH, Frajblat M, Gilbert RO, Sommer U, Costello CE. Tritrichomonas foetus induces apoptotic cell death in bovine vaginal epithelial cells. Infect Immun. 2004 Jul; 72(7):4151-8. PMID: 15213160; PMCID: PMC427413

Francesconi LC, Zheng Y, Bartis J, Blumenstein M, Costello C, De Rosch MA. Preparation and characterization of [99TcO] apcitide: a technetium labeled peptide. Inorg Chem. 2004 May 3; 43(9):2867-75. PMID: 15106974

Cipollo JF, Awad A, Costello CE, Robbins PW, Hirschberg CB. Biosynthesis in vitro of Caenorhabditis elegans phosphorylcholine oligosaccharides. Proc Natl Acad Sci U S A. 2004 Mar 9; 101(10):3404-8.View Related Profiles.

Hirschberg, Carlos
Costello, Catherine
Robbins, Phillips

PMID: 14993596; PMCID: PMC373474

Moody DB, Young DC, Cheng TY, Rosat JP, Roura-Mir C, O'Connor PB, Zajonc DM, Walz A, Miller MJ, Levery SB, Wilson IA, Costello CE, Brenner MB. T cell activation by lipopeptide antigens. Science. 2004 Jan 23; 303(5657):527-31. PMID: 14739458

Sethuraman M, McComb ME, Heibeck T, Costello CE, Cohen RA. Isotope-coded affinity tag approach to identify and quantify oxidant-sensitive protein thiols. Mol Cell Proteomics. 2004 Mar; 3(3):273-8.View Related Profiles.

Costello, Catherine
McComb, Mark
Cohen, Richard

PMID: 14726493

Prokaeva T, Costello C, Theberge R, Akar H, Connors L, Smith P, Lim A, Skinner M, Metayer M. Amyloid and Amyloidosis. Familial Amyloidosis. 2004; 360-362. View Publication
Connors L, Lim A, Jiang Y, Costello C, Theberge R, Eberhard J, Skinner M. Amyloid and Amyloidosis. Detection and Characterization of Post-Translational Modifications in Al Light Chain Proteins by Mass Spectrometry. 2004; 46-48. View Publication
Budnik BA, Moyer SC, Pittman JL, Ivleva VB, Sommer U, Costello CE, O'Connor P. High pressure MALDI-FTMS: implications for proteomics. International Journal of Mass Spectrometry. 2004; 234(1):202-212. View Publication
Prokaeva T, Costello C, Theberge R, Connors L, Lim A, Mccomb ME, Skinner M. Amyloid and Amyloidosis. Clinical Diagnosis of Familial Transthyretin Amyloidosis by Automated Data Acquisition and Processing with Quadrupole Orthogonal Time-of-Flight Mass Spectrometry. 2004; 348-350. View Publication

O'Connor PB, Budnik BA, Ivleva VB, Kaur P, Moyer SC, Pittman JL, Costello CE. A high pressure matrix-assisted laser desorption ion source for Fourier transform mass spectrometry designed to accommodate large targets with diverse surfaces. J Am Soc Mass Spectrom. 2004 Jan; 15(1):128-32. PMID: 14698563

Abraham CR, Oh S, Ellenstein A, Berg E, O'Connor P, Costello CE, Van Nostrand WE, Neve R. P1-201 In search for APP-binding proteins. Neurobiology of Aging. 2004; 25(2). View Publication
Costello CE, Blackmun-Ross KE, Budnik BA, Elkin Y, Ivleva VB, Steen JA, Pittman JL, Xie B, Mccomb ME, O'Connor PB, Zaia J. Glycobiology. Sample preparation and mass spectral fragmentation methods for use in glycobiology. 2004.

Ciucanu I, Costello CE. Elimination of oxidative degradation during the per-O-methylation of carbohydrates. J Am Chem Soc. 2003 Dec 31; 125(52):16213-9. PMID: 14692762

Moyer SC, Budnik BA, Pittman JL, Costello CE, O'Connor PB. Attomole peptide analysis by high-pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry. Anal Chem. 2003 Dec 1; 75(23):6449-54. PMID: 14640713

Zaia J, Li XQ, Chan SY, Costello CE. Tandem mass spectrometric strategies for determination of sulfation positions and uronic acid epimerization in chondroitin sulfate oligosaccharides. J Am Soc Mass Spectrom. 2003 Nov; 14(11):1270-81.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 14597117

Yang J, Gitlin I, Krishnamurthy VM, Vazquez JA, Costello CE, Whitesides GM. Synthesis of monodisperse polymers from proteins. J Am Chem Soc. 2003 Oct 15; 125(41):12392-3. PMID: 14531666

Lim A, Sengupta S, McComb ME, Théberge R, Wilson WG, Costello CE, Jacobsen DW. In vitro and in vivo interactions of homocysteine with human plasma transthyretin. J Biol Chem. 2003 Dec 12; 278(50):49707-13.View Related Profiles.

Costello, Catherine
McComb, Mark
Theberge, Roger

PMID: 14507924

Rauch J, Gumperz J, Robinson C, Sköld M, Roy C, Young DC, Lafleur M, Moody DB, Brenner MB, Costello CE, Behar SM. Structural features of the acyl chain determine self-phospholipid antigen recognition by a CD1d-restricted invariant NKT (iNKT) cell. J Biol Chem. 2003 Nov 28; 278(48):47508-15. PMID: 12963715; PMCID: PMC3465362

Connors LH, Lim A, Prokaeva T, Roskens VA, Costello CE. Tabulation of human transthyretin (TTR) variants, 2003. Amyloid. 2003 Sep; 10(3):160-84.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Prokaeva, Tatiana

PMID: 14640030

Lim A, Prokaeva T, McComb ME, Connors LH, Skinner M, Costello CE. Identification of S-sulfonation and S-thiolation of a novel transthyretin Phe33Cys variant from a patient diagnosed with familial transthyretin amyloidosis. Protein Sci. 2003 Aug; 12(8):1775-85.View Related Profiles.

Costello, Catherine
Connors, Lawreen
McComb, Mark
Skinner, Martha
Prokaeva, Tatiana

PMID: 12876326; PMCID: PMC2323963

Leymarie N, Costello CE, O'Connor PB. Electron capture dissociation initiates a free radical reaction cascade. J Am Chem Soc. 2003 Jul 23; 125(29):8949-58.View Related Profiles.

Costello, Catherine
Leymarie, Nancy

PMID: 12862492

Hammarström P, Sekijima Y, White JT, Wiseman RL, Lim A, Costello CE, Altland K, Garzuly F, Budka H, Kelly JW. D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis? Biochemistry. 2003 Jun 10; 42(22):6656-63. PMID: 12779320

Zaia J, Costello CE. Tandem mass spectrometry of sulfated heparin-like glycosaminoglycan oligosaccharides. Anal Chem. 2003 May 15; 75(10):2445-55.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 12918989

Kopp DA, Berg EA, Costello CE, Lippard SJ. Structural features of covalently cross-linked hydroxylase and reductase proteins of soluble methane monooxygenase as revealed by mass spectrometric analysis. J Biol Chem. 2003 Jun 6; 278(23):20939-45. PMID: 12660237

Costello CE, Mccomb ME, O'Connor PB, Zaia J. 8th Annual Conference of the Society-for-Glycobiology. Mass spectrometry-based methods for revealing the Glyeans' family secrets. Glycobiology. 2003.
Naggar EF, Costello CE, Zaia J. 8th Annual Conference of the Society-for-Glycobiology. Identification and sequencing of protein binding heparin-like glycosaminoglycan oligosaccharides. Glycobiology. 2003; 13.

O'Connor PB, Costello CE, Earle WE. A high voltage RF oscillator for driving multipole ion guides. J Am Soc Mass Spectrom. 2002 Dec; 13(12):1370-5. PMID: 12484456

Yao Y, Berg EA, Costello CE, Troxler RF, Oppenheim FG. Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches. J Biol Chem. 2003 Feb 14; 278(7):5300-8.View Related Profiles.

Costello, Catherine
Oppenheim, Frank

PMID: 12444093

Cipollo JF, Costello CE, Hirschberg CB. The fine structure of Caenorhabditis elegans N-glycans. J Biol Chem. 2002 Dec 20; 277(51):49143-57.View Related Profiles.

Hirschberg, Carlos
Costello, Catherine

PMID: 12361949

Inouye H, Bond JE, Deverin SP, Lim A, Costello CE, Kirschner DA. Molecular organization of amyloid protofilament-like assembly of betabellin 15D: helical array of beta-sandwiches. Biophys J. 2002 Sep; 83(3):1716-27. PMID: 12202394; PMCID: PMC1302267

Leymarie N, Berg EA, McComb ME, O'Connor PB, Grogan J, Oppenheim FG, Costello CE. Tandem mass spectrometry for structural characterization of proline-rich proteins: application to salivary PRP-3. Anal Chem. 2002 Aug 15; 74(16):4124-32.View Related Profiles.

Costello, Catherine
Oppenheim, Frank
McComb, Mark
Leymarie, Nancy

PMID: 12199583

McClellan JE, Costello CE, O'Connor PB, Zaia J. Influence of charge state on product ion mass spectra and the determination of 4S/6S sulfation sequence of chondroitin sulfate oligosaccharides. Anal Chem. 2002 Aug 1; 74(15):3760-71.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 12175164

Gurcha SS, Baulard AR, Kremer L, Locht C, Moody DB, Muhlecker W, Costello CE, Crick DC, Brennan PJ, Besra GS. Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. Biochem J. 2002 Jul 15; 365(Pt 2):441-50. PMID: 11931640; PMCID: PMC1222681

Hopkins CE, O'Connor PB, Allen KN, Costello CE, Tolan DR. Chemical-modification rescue assessed by mass spectrometry demonstrates that gamma-thia-lysine yields the same activity as lysine in aldolase. Protein Sci. 2002 Jul; 11(7):1591-9. PMID: 12070312; PMCID: PMC2373652

Lim A, Prokaeva T, Connor LH, Falk RH, Skinner M, Costello CE. Identification of a novel transthyretin Thr59Lys/Arg104His. A case of compound heterozygosity in a Chinese patient diagnosed with familial transthyretin amyloidosis. Amyloid. 2002 Jun; 9(2):134-40.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Skinner, Martha
Prokaeva, Tatiana

PMID: 12440486

O'Connor PB, Mirgorodskaya E, Costello CE. High pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for minimization of ganglioside fragmentation. J Am Soc Mass Spectrom. 2002 Apr; 13(4):402-7. PMID: 11951978

Mirgorodskaya E, O'Connor PB, Costello CE. A general method for precalculation of parameters for sustained off resonance irradiation/collision-induced dissociation. J Am Soc Mass Spectrom. 2002 Apr; 13(4):318-24. PMID: 11951969

Lim A, Prokaeva T, McComb ME, O'Connor PB, Théberge R, Connors LH, Skinner M, Costello CE. Characterization of transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping and DNA sequence analysis. Anal Chem. 2002 Feb 15; 74(4):741-51.View Related Profiles.

Costello, Catherine
Connors, Lawreen
McComb, Mark
Skinner, Martha
Theberge, Roger
Prokaeva, Tatiana

PMID: 11866053

Panepinto MJ, Berg EA, Mccomb ME, Fine RE, Costello CE. Characterization of membrane lipids of dense core vesicles from rabbit brain. 2002.
Ratts R, Zeng H, Berg EA, Costello CE, vanderSpek J, Murphy JR. In vitro translocation assay for the diphtheria toxin catalytic domain across the endosomal membrane: Implications for understanding the pathophysiology of the botulinum and tetanus neurotoxins. Archiv für Experimentelle Pathologie und Pharmakologie. 2002; 365:R35.
Kirschner DA, Inouye H, Bond JP, Deverin SP, Teeter MT, El-Agnaf O, Henry C, Costello CE, Lim A. X-ray fiber diffraction analysis of amyloid assemblies. 2002.
Lim A, Makhov AM, Connors LH, Bond J, Inouye H, Griffith J, Kirschner DA, Costello CE. Peptides for the New Millennium: Proceedings of the 16th American Peptide Symposium June 26–July 1, 1999, Minneapolis, Minnesota, U.S.A. Characterization of betabellins 15D and 16D, designed beta-sandwich proteins that have amyloidogenic properties. 2002; 22-23. View Publication
Zaia J, Costello CE. 7th Annual Conference of the Society-for-Glycobiology. A new approach for sequencing heparins. Glycobiology. 2002; 12.

Zaia J, McClellan JE, Costello CE. Tandem mass spectrometric determination of the 4S/6S sulfation sequence in chondroitin sulfate oligosaccharides. Anal Chem. 2001 Dec 15; 73(24):6030-9.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 11791576

Håkansson K, Cooper HJ, Emmett MR, Costello CE, Marshall AG, Nilsson CL. Electron capture dissociation and infrared multiphoton dissociation MS/MS of an N-glycosylated tryptic peptic to yield complementary sequence information. Anal Chem. 2001 Sep 15; 73(18):4530-6. PMID: 11575803

Lim A, Wally J, Walsh MT, Skinner M, Costello CE. Identification and location of a cysteinyl posttranslational modification in an amyloidogenic kappa1 light chain protein by electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry. Anal Biochem. 2001 Aug 1; 295(1):45-56.View Related Profiles.

Costello, Catherine
Skinner, Martha

PMID: 11476544

Yao Y, Grogan J, Zehnder M, Lendenmann U, Nam B, Wu Z, Costello CE, Oppenheim FG. Compositional analysis of human acquired enamel pellicle by mass spectrometry. Arch Oral Biol. 2001 Apr; 46(4):293-303.View Related Profiles.

Costello, Catherine
Oppenheim, Frank

PMID: 11269863

Upchurch GR, Goodman DG, Willoughby SR, Zhang YY, Welch GN, Freedman JE, Ye S, Costello CE, Loscalzo J. Heparin reacts with and inactivates nitric oxide. J Cardiovasc Pharmacol Ther. 2001 Apr; 6(2):163-73.View Related Profiles.

Costello, Catherine
Freedman, Jane

PMID: 11509923

Costello CE, Beach DH, Singh BN. Acidic glycerol lipids of Trichomonas vaginalis and Tritrichomonas foetus. Biol Chem. 2001 Feb; 382(2):275-82. PMID: 11308025

Zaia J, Costello CE. Compositional analysis of glycosaminoglycans by electrospray mass spectrometry. Anal Chem. 2001 Jan 15; 73(2):233-9.View Related Profiles.

Costello, Catherine
Zaia, Joseph

PMID: 11199971

Zaia J, McClellan JE, Costello CE. Tandem mass spectrometric sequencing of glycosaminoglycans. Glycobiology. 2001; 11(10):877.
Connors LH, Lim A, Prokaeva T, Metayer M, Costello CE, Skinner M. Familial transthyretin amyloidosis: Recent Boston experience. Amyloid. 2001; 8:158-159.
O'Connor PB, Mirgorodskaya E, Costello CE. A new high pressure Matrix-Assisted Laser Desorption/Ionization Fourier Transform Mass Spectrometry ion source for analysis of gangliosides. Glycobiology. 2001; 11(10):880.
Costello CE, Lim A, O'Connor PB, Prokaeva T, Connors LH, Skinner M. Identification of novel transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping. Amyloid. 2001; 8:104-105.
Lim A, Wally J, Walsh MT, Skinner M, Costello CE. Detection and characterization of post-translational modifications in amyloidogenic kappa 1 light chain proteins by mass spectrometric peptide mapping. Amyloid. 2001; 8:61-62.
Mirgorodskaya E, Leymarie N, O'Conner PB, Costello CE. Comparison of Infrared Multiphoton Decomposition (IRMPD) and Sustained Off-Resonance Irradiation Collision-Induced Decomposition (SORI-CID) for structural analysis of derivatized and native oligosaccharides. Glycobiology. 2001; 11(10):926.

O'Connor PB, Costello CE. A high pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry ion source for thermal stabilization of labile biomolecules. Rapid Commun Mass Spectrom. 2001; 15(19):1862-8. PMID: 11565105

Hakansson K, Cooper HJ, Emmett MR, Costello CE, Marshall AG, Nilsson CL. ECD and IRMPD MS/MS of an N-glycosylated tryptic peptide to yield complementary sequence information. Analytical Chemistry. 2001; 73(18):4530-4536. View Publication

O'Connor PB, Costello CE. Internal calibration on adjacent samples (InCAS) with Fourier transform mass spectrometry. Anal Chem. 2000 Dec 15; 72(24):5881-5. PMID: 11140752

Li H, Macdonald DM, Hronowski X, Costello CE, Leeman SE, Boyd ND. Further definition of the substance P (SP)/neurokinin-1 receptor complex. MET-174 is the site of photoinsertion p-benzoylphenylalanine4 SP. J Biol Chem. 2001 Apr 6; 276(14):10589-93.View Related Profiles.

Costello, Catherine
Leeman, Susan

PMID: 11116140

Naik RS, Branch OH, Woods AS, Vijaykumar M, Perkins DJ, Nahlen BL, Lal AA, Cotter RJ, Costello CE, Ockenhouse CF, Davidson EA, Gowda DC. Glycosylphosphatidylinositol anchors of Plasmodium falciparum: molecular characterization and naturally elicited antibody response that may provide immunity to malaria pathogenesis. J Exp Med. 2000 Dec 4; 192(11):1563-76. PMID: 11104799; PMCID: PMC2193092

O'Connor PB, Costello CE. Application of multishot acquisition in Fourier transform mass spectrometry. Anal Chem. 2000 Oct 15; 72(20):5125-30. PMID: 11055737

Lim A, Makhov AM, Bond J, Inouye H, Connors LH, Griffith JD, Erickson BW, Kirschner DA, Costello CE. Betabellins 15D and 16D, de Novo designed beta-sandwich proteins that have amyloidogenic properties. J Struct Biol. 2000 Jun; 130(2-3):363-70.View Related Profiles.

Costello, Catherine
Connors, Lawreen

PMID: 10940239

Moody DB, Ulrichs T, Mühlecker W, Young DC, Gurcha SS, Grant E, Rosat JP, Brenner MB, Costello CE, Besra GS, Porcelli SA. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature. 2000 Apr 20; 404(6780):884-8. PMID: 10786796

Connors LH, Richardson AM, Théberge R, Costello CE. Tabulation of transthyretin (TTR) variants as of 1/1/2000. Amyloid. 2000 Mar; 7(1):54-69.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Theberge, Roger

PMID: 10842707

Théberge R, Connors LH, Skinner M, Costello CE. Detection of transthyretin variants using immunoprecipitation and matrix-assisted laser desorption/ionization bioreactive probes: a clinical application of mass spectrometry. J Am Soc Mass Spectrom. 2000 Feb; 11(2):172-5.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Skinner, Martha
Theberge, Roger

PMID: 10689671

Inouye H, Lim A, Shinchuk LB, Bond J, Reixach N, Deverin S, Makhov AM, Griffith JD, Costello CE, Blondelle SE, Kirschner DA. Amyloid structure modeled using designed polypeptides. Journal of Neurochemistry. 2000; 74:S12.
Zaia J, Costello CE. Characterization of glycosaminoglycan structure using mass spectrometry. Glycobiology. 2000; 10(10):1093.

Popham DL, Meador-Parton J, Costello CE, Setlow P. Spore peptidoglycan structure in a cwlD dacB double mutant of Bacillus subtilis. J Bacteriol. 1999 Oct; 181(19):6205-9. PMID: 10498740; PMCID: PMC103655

Connors LH, Théberge R, Skare J, Costello CE, Falk RH, Skinner M. A new transthyretin variant (Ser23Asn) associated with familial amyloidosis in a Portuguese patient. Amyloid. 1999 Jun; 6(2):114-8.View Related Profiles.

Costello, Catherine
Connors, Lawreen
Skinner, Martha
Theberge, Roger

PMID: 10439117

Niemelä R, Natunen J, Penttilä L, Salminen H, Helin J, Maaheimo H, Costello CE, Renkonen O. Isolation and characterization of linear polylactosamines containing one and two site-specifically positioned Lewis x determinants: WGA agarose chromatography in fractionation of mixtures generated by random, partial enzymatic alpha3-fucosylation of pure polylactosamines. Glycobiology. 1999 May; 9(5):517-26. PMID: 10207184

Kuliopulos A, Covic L, Seeley SK, Sheridan PJ, Helin J, Costello CE. Plasmin desensitization of the PAR1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy. Biochemistry. 1999 Apr 6; 38(14):4572-85. PMID: 10194379

Viseux N, Costello CE, Domon B. Post-source decay mass spectrometry: optimized calibration procedure and structural characterization of permethylated oligosaccharides. J Mass Spectrom. 1999 Apr; 34(4):364-76. PMID: 10226363

Perreault H, Costello CE. Stereochemical effects on the mass spectrometric behavior of native and derivatized trisaccharide isomers: comparisons with results from molecular modeling. J Mass Spectrom. 1999 Mar; 34(3):184-97. PMID: 10214722

Théberge R, Connors L, Skare J, Skinner M, Falk RH, Costello CE. A new amyloidogenic transthyretin variant (Val122Ala) found in a compound heterozygous patient. Amyloid. 1999 Mar; 6(1):54-8.View Related Profiles.
Costello, Catherine
Connors, Lawreen
Skinner, Martha
Theberge, Roger
PMID: 10211412