Catherine E. Costello, PhD
William Fairfield Warren Distinguished Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

PhD, Georgetown University
MS, Georgetown University
AB, Emmanuel College



Catherine Costello came to Boston University in 1994. That year she established the Center for Biomedical Mass Spectrometry, which has become an internationally recognized research center. She holds her primary appointment in the Chobanian & Avedisian School of Medicine Biochemistry & Cell Biology Department, with secondary appointments in the Department of Physiology & Biophysics and the Department of Chemistry. Her research, which focuses on determining the structures and functions of biologically important polymers, has revolutionized an important area of biochemistry by providing insights into the structures of molecules responsible for human disease. She is the author or co-author of more than 400 scientific papers, serves on a number of advisory boards and editorial boards of major journals, and has received numerous awards and honors, including the 2009 Thomson Medal from the International Mass Spectrometry Foundation (IMSF), the 2010 Field and Franklin Award from the American Chemical Society (ACS), and the 2017 Distinguished Contribution Award from the American Society for Mass Spectrometry (ASMS), the three highest honors in her field. She is a Fellow of the ACS and the American Association for the Advancement of Science. She has served as President of IMSF, ASMS, and the Human Proteome Organization.

Professor
Boston University Chobanian & Avedisian School of Medicine
Chemistry


Research Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics


Director
Boston University Chobanian & Avedisian School of Medicine
Center for Biomedical Mass Spectrometry


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Amyloidosis Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Mass Spectrometry analyses, matrix-assisted laser desorption/ionization and electrospray ionization tandem analyses
05/01/2023 - 05/01/2025 (PI)
Nutricia Research B.V


Cellular and humoral immunity in Lyme arthritis
01/08/2019 - 12/31/2023 (Subcontract PI)
Massachusetts General Hospital NIH NIAID
5R01AI144365-05

Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine
08/01/2019 - 12/31/2022 (PI)
NIH/National Institute of General Medical Sciences
5R24GM134210-03

Mass Spectrometry based Characterization of (a) O-glycan GAG (b) Enzymatic reaction on physiologically relevant Glycans and (c) Glycovariants and Charge variants of Biologics
04/01/2021 - 08/31/2022 (PI)
Takeda Pharmaceuticals North America, Inc.


Mass Spectrometry analyses, matrix-assisted laser desorption/ionization and electrospray ionization tandem analyses
12/01/2018 - 12/31/2021 (PI)
Nutricia Research B.V


Investigating PCR Reagent Quality and Its Impact on SARS-CoV-2 Assay Accuracy and Precision
06/01/2021 - 10/31/2021 (PI)
Waters Technologies Corporation


IPA Agreement for Juan Wei
04/05/2019 - 09/27/2019 (PI)
Department of Veterans Administration, Bedford


MASS SPECTROMETRY RESOURCE FOR BIOLOGY AND MEDICINE
06/01/2016 - 05/31/2019 (PI)
NIH/National Institute of General Medical Sciences
4P41GM104603-20

A Thermo-Fisher Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer System
03/06/2018 - 03/05/2019 (PI)
NIH/Office of the Director
1S10OD021728-01A1

A Thermo-Fisher Scientific Q-Exactive HF Mass Spectrometry System
05/01/2016 - 04/30/2017 (Key Person)
PI: Joseph Zaia, PhD
NIH/Office of the Director
1S10OD021651-01

Showing 10 of 24 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2021 Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine 5R24GM134210-03
2020 Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine 5R24GM134210-02
2019 Legacy Support During Closure of the Mass Spectrometry Resource for Biology and Medicine 1R24GM134210-01
2018 A Thermo-Fisher Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer System 1S10OD021728-01A1 2
2017 Mass Spectrometry Resource for Biology and Medicine 3P41GM104603-20S1 148
2016 Mass Spectrometry Resource for Biology and Medicine 4P41GM104603-20 148
2015 Mass Spectrometry Resource for Biology and Medicine 5P41GM104603-19 148
2014 Mass Spectrometry Resource for Biology and Medicine 5P41GM104603-18 148
2013 TAS::75 0872::TAS PROTEOMIC CENTERS: MODIFICATION OF CARDIOVASCULAR PROTEINS BY 268201000031C-5-0-1
2013 Mass Spectrometry Resource for Biology and Medicine 5P41GM104603-17 148
Showing 10 of 417 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Nador E, Xia C, Santangelo PJ, Whaley KJ, Costello CE, Anderson DJ. Platform-Specific Fc N-Glycan Profiles of an Antisperm Antibody. Antibodies (Basel). 2024 Mar 06; 13(1).View Related Profiles. PMID: 38534207; PMCID: PMC10967333; DOI: 10.3390/antib13010017;
     
  2. Li R, Xia C, Wu S, Downs MJ, Tong H, Tursumamat N, Zaia J, Costello CE, Lin C, Wei J. Direct and Detailed Site-Specific Glycopeptide Characterization by Higher-Energy Electron-Activated Dissociation Tandem Mass Spectrometry. Anal Chem. 2024 Jan 23; 96(3):1251-1258.View Related Profiles. PMID: 38206681; PMCID: PMC10885852; DOI: 10.1021/acs.analchem.3c04484;
     
  3. Rahimi N, White MR, Amraei R, Lotfollahzadeh S, Xia C, Michalak M, Costello CE, Mühlberger E. Calreticulin Regulates SARS-CoV-2 Spike Protein Turnover and Modulates SARS-CoV-2 Infectivity. Cells. 2023 Nov 23; 12(23).View Related Profiles. PMID: 38067122; PMCID: PMC10705507; DOI: 10.3390/cells12232694;
     
  4. Liyanage OT, Xia C, Ringler S, Stahl B, Costello CE. Defining the Ceramide Composition of Bovine and Human Milk Gangliosides by Direct Infusion ESI-CID Tandem Mass Spectrometry of Native and Permethylated Molecular Species. Anal Chem. 2023 Nov 14; 95(45):16465-16473. PMID: 37877731; PMCID: PMC10652237; DOI: 10.1021/acs.analchem.3c00737;
     
  5. Kanjana K, Strle K, Lochhead RB, Pianta A, Mateyka LM, Wang Q, Arvikar SL, Kling DE, Deangelo CA, Curham L, Barbour AG, Costello CE, Moon JJ, Steere AC. Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis. J Clin Invest. 2023 Sep 01; 133(17). PMID: 37471146; PMCID: PMC10471169; DOI: 10.1172/JCI161170;
     
  6. Zhang L, Liu X, Wang X, Zhu G, Song H, Cheng R, Naowarojna N, Costello CE, Liu P. Correspondence on "Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1". Angew Chem Int Ed Engl. 2023 Sep 11; 62(37):e202218643. PMID: 37541669; PMCID: PMC10528348; DOI: 10.1002/anie.202218643;
     
  7. Wei J, Papanastasiou D, Kosmopoulou M, Smyrnakis A, Hong P, Tursumamat N, Klein JA, Xia C, Tang Y, Zaia J, Costello CE, Lin C. De novo glycan sequencing by electronic excitation dissociation MS2-guided MS3 analysis on an Omnitrap-Orbitrap hybrid instrument. Chem Sci. 2023 Jun 21; 14(24):6695-6704.View Related Profiles. PMID: 37350811; PMCID: PMC10284134; DOI: 10.1039/d3sc00870c;
     
  8. Lotfollahzadeh S, Xia C, Amraei R, Hua N, Kandror KV, Farmer SR, Wei W, Costello CE, Chitalia V, Rahimi N. Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity. Mol Metab. 2023 Jul; 73:101744.View Related Profiles. PMID: 37245847; PMCID: PMC10267597; DOI: 10.1016/j.molmet.2023.101744;
     
  9. Sanes JT, Costello CE, Steere AC. Heightened Proinflammatory Glycosylation of Borrelia burgdorferi IgG Antibodies in Synovial Fluid in Patients With Antibiotic-Refractory Lyme Arthritis. Arthritis Rheumatol. 2023 Jul; 75(7):1263-1274. PMID: 36716113; PMCID: PMC10313735; DOI: 10.1002/art.42465;
     
  10. van der Wel H, Garcia AM, Gas-Pascual E, Willis MM, Kim HW, Bandini G, Gaye MM, Costello CE, Samuelson J, West CM. Spindly is a nucleocytosolic O-fucosyltransferase in Dictyostelium and related proteins are widespread in protists and bacteria. Glycobiology. 2023 Apr 19; 33(3):225-244.View Related Profiles. PMID: 36250576; PMCID: PMC10114647; DOI: 10.1093/glycob/cwac071;
     
Showing 10 of 472 results. Show More