Keywords
Last Name

Konstantin Kandror, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-5049
ORCID ORCID Icon0000-0002-8601-9313
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Research Expertise & Professional Interests
Expertise includes: Insulin action; Dipocyte biology; Membrane traffic.

 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
2014 Insulin regulation of cell nutrition 2R56DK052057-16
2013 Insulin regulation of cell nutrition 5R01DK052057-15 6
2012 Regulation of lipolysis by mTORC1 5R21AG039612-02 3
2012 Insulin regulation of cell nutrition 5R01DK052057-14 6
2011 Regulation of lipolysis by mTORC1 1R21AG039612-01A1 3
2011 Insulin regulation of cell nutrition 5R01DK052057-13 6
2010 Insulin regulation of cell nutrition 3R01DK052057-11A2S1 6
2010 Secretion from adipose cells 3R01DK056736-09S1 26
2010 Insulin regulation of cell nutrition 5R01DK052057-12 6
2009 Secretion from adipose cells 5R01DK056736-09 26
Showing the 10 most recent of 33 results. Show All Results

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Singh M, Kaur R, Lee MJ, Pickering RT, Sharma VM, Puri V, Kandror KV. Fat-specific Protein 27 Inhibits Lipolysis by Facilitating the Inhibitory Effect of Transcription Factor Egr1 on Transcription of Adipose Triglyceride Lipase. J Biol Chem. 2014 May 23; 289(21):14481-7.
    View in: PubMed
  2. Huang G, Buckler-Pena D, Nauta T, Singh M, Asmar A, Shi J, Kim JY, Kandror KV. Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin. Mol Biol Cell. 2013 Oct; 24(19):3115-22.
    View in: PubMed
  3. Chakrabarti P, Kim JY, Singh M, Shin YK, Kim J, Kumbrink J, Wu Y, Lee MJ, Kirsch KH, Fried SK, Kandror KV. Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway. Mol Cell Biol. 2013 Sep; 33(18):3659-66.
    View in: PubMed
  4. Kim JY, Kandror KV. The first luminal loop confers insulin responsiveness to glucose transporter 4. Mol Biol Cell. 2012 Mar; 23(5):910-7.
    View in: PubMed
  5. Karki S, Chakrabarti P, Huang G, Wang H, Farmer SR, Kandror KV. The multi-level action of fatty acids on adiponectin production by fat cells. PLoS One. 2011; 6(11):e28146.
    View in: PubMed
  6. Chakrabarti P, English T, Karki S, Qiang L, Tao R, Kim J, Luo Z, Farmer SR, Kandror KV. SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL. J Lipid Res. 2011 Sep; 52(9):1693-701.
    View in: PubMed
  7. Chakrabarti P, Kandror KV. Adipose triglyceride lipase: a new target in the regulation of lipolysis by insulin. Curr Diabetes Rev. 2011 Jul; 7(4):270-7.
    View in: PubMed
  8. Kandror KV, Pilch PF. The sugar is sIRVed: sorting Glut4 and its fellow travelers. Traffic. 2011 Jun; 12(6):665-71.
    View in: PubMed
  9. Bogan JS, Kandror KV. Biogenesis and regulation of insulin-responsive vesicles containing GLUT4. Curr Opin Cell Biol. 2010 Aug; 22(4):506-12.
    View in: PubMed
  10. Chakrabarti P, English T, Shi J, Smas CM, Kandror KV. Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage. Diabetes. 2010 Apr; 59(4):775-81.
    View in: PubMed
  11. Jedrychowski MP, Gartner CA, Gygi SP, Zhou L, Herz J, Kandror KV, Pilch PF. Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. J Biol Chem. 2010 Jan 1; 285(1):104-14.
    View in: PubMed
  12. Bakirtzi K, Belfort G, Lopez-Coviella I, Kuruppu D, Cao L, Abel ED, Brownell AL, Kandror KV. Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues. J Neurosci. 2009 Apr 22; 29(16):5193-201.
    View in: PubMed
  13. Li LV, Bakirtzi K, Watson RT, Pessin JE, Kandror KV. The C-terminus of GLUT4 targets the transporter to the perinuclear compartment but not to the insulin-responsive vesicles. Biochem J. 2009 Apr 1; 419(1):105-12, 1 p following 112.
    View in: PubMed
  14. Chakrabarti P, Kandror KV. FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes. J Biol Chem. 2009 May 15; 284(20):13296-300.
    View in: PubMed
  15. Wright JJ, Kim J, Buchanan J, Boudina S, Sena S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel ED. Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding. Cardiovasc Res. 2009 May 1; 82(2):351-60.
    View in: PubMed
  16. Shi J, Huang G, Kandror KV. Self-assembly of Glut4 storage vesicles during differentiation of 3T3-L1 adipocytes. J Biol Chem. 2008 Oct 31; 283(44):30311-21.
    View in: PubMed
  17. Chakrabarti P, Anno T, Manning BD, Luo Z, Kandror KV. The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5'-untranslated region in the expression of leptin messenger ribonucleic acid. Mol Endocrinol. 2008 Oct; 22(10):2260-7.
    View in: PubMed
  18. Lee SJ, Jeon H, Kandror KV. Alpha-synuclein is localized in a subpopulation of rat brain synaptic vesicles. Acta Neurobiol Exp (Wars). 2008; 68(4):509-15.
    View in: PubMed
  19. Shi J, Kandror KV. Study of glucose uptake in adipose cells. Methods Mol Biol. 2008; 456:307-15.
    View in: PubMed
  20. Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV, Hsu VW. An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol. 2007 Jul 30; 178(3):453-64.
    View in: PubMed
  21. Shi J, Kandror KV. The luminal Vps10p domain of sortilin plays the predominant role in targeting to insulin-responsive Glut4-containing vesicles. J Biol Chem. 2007 Mar 23; 282(12):9008-16.
    View in: PubMed
  22. Xu Z, Huang G, Kandror KV. Phosphatidylinositol 4-kinase type IIalpha is targeted specifically to cellugyrin-positive glucose transporter 4 vesicles. Mol Endocrinol. 2006 Nov; 20(11):2890-7.
    View in: PubMed
  23. Kandror KV, Pilch PF. Isolation of GLUT4 storage vesicles. Curr Protoc Cell Biol. 2006 Apr; Chapter 3:Unit 3.20.
    View in: PubMed
  24. Tzatsos A, Kandror KV. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol. 2006 Jan; 26(1):63-76.
    View in: PubMed
  25. Shi J, Kandror KV. Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes. Dev Cell. 2005 Jul; 9(1):99-108.
    View in: PubMed
  26. Li LV, Kandror KV. Golgi-localized, gamma-ear-containing, Arf-binding protein adaptors mediate insulin-responsive trafficking of glucose transporter 4 in 3T3-L1 adipocytes. Mol Endocrinol. 2005 Aug; 19(8):2145-53.
    View in: PubMed
  27. Belfort GM, Bakirtzi K, Kandror KV. Cellugyrin induces biogenesis of synaptic-like microvesicles in PC12 cells. J Biol Chem. 2005 Feb 25; 280(8):7262-72.
    View in: PubMed
  28. Wang YL, Guo W, Zang Y, Yaney GC, Vallega G, Getty-Kaushik L, Pilch P, Kandror K, Corkey BE. Acyl coenzyme a synthetase regulation: putative role in long-chain acyl coenzyme a partitioning. Obes Res. 2004 Nov; 12(11):1781-8.
    View in: PubMed
  29. Abel ED, Graveleau C, Betuing S, Pham M, Reay PA, Kandror V, Kupriyanova T, Xu Z, Kandror KV. Regulation of insulin-responsive aminopeptidase expression and targeting in the insulin-responsive vesicle compartment of glucose transporter isoform 4-deficient cardiomyocytes. Mol Endocrinol. 2004 Oct; 18(10):2491-501.
    View in: PubMed
  30. Malikova M, Shi J, Kandror KV. V-type ATPase is involved in biogenesis of GLUT4 vesicles. Am J Physiol Endocrinol Metab. 2004 Sep; 287(3):E547-52.
    View in: PubMed
  31. Watson RT, Khan AH, Furukawa M, Hou JC, Li L, Kanzaki M, Okada S, Kandror KV, Pessin JE. Entry of newly synthesized GLUT4 into the insulin-responsive storage compartment is GGA dependent. EMBO J. 2004 May 19; 23(10):2059-70.
    View in: PubMed
  32. Belfort GM, Kandror KV. Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells. J Biol Chem. 2003 Nov 28; 278(48):47971-8.
    View in: PubMed
  33. Kandror KV. A long search for Glut4 activation. Sci STKE. 2003 Feb 11; 2003(169):PE5.
    View in: PubMed
  34. Xu Z, Kandror KV. Translocation of small preformed vesicles is responsible for the insulin activation of glucose transport in adipose cells. Evidence from the in vitro reconstitution assay. J Biol Chem. 2002 Dec 13; 277(50):47972-5.
    View in: PubMed
  35. Roh C, Han J, Tzatsos A, Kandror KV. Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes. Am J Physiol Endocrinol Metab. 2003 Feb; 284(2):E322-30.
    View in: PubMed
  36. Kupriyanova TA, Kandror V, Kandror KV. Isolation and characterization of the two major intracellular Glut4 storage compartments. J Biol Chem. 2002 Mar 15; 277(11):9133-8.
    View in: PubMed
  37. Thoidis G, Kandror KV. A Glut4-vesicle marker protein, insulin-responsive aminopeptidase, is localized in a novel vesicular compartment in PC12 cells. Traffic. 2001 Aug; 2(8):577-87.
    View in: PubMed
  38. Roh C, Roduit R, Thorens B, Fried S, Kandror KV. Lipoprotein lipase and leptin are accumulated in different secretory compartments in rat adipocytes. J Biol Chem. 2001 Sep 21; 276(38):35990-4.
    View in: PubMed
  39. Lee HJ, Chun M, Kandror KV. Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling. J Biol Chem. 2001 May 18; 276(20):16597-600.
    View in: PubMed
  40. Kupriyanova TA, Kandror KV. Cellugyrin is a marker for a distinct population of intracellular Glut4-containing vesicles. J Biol Chem. 2000 Nov 17; 275(46):36263-8.
    View in: PubMed
  41. Roh C, Thoidis G, Farmer SR, Kandror KV. Identification and characterization of leptin-containing intracellular compartment in rat adipose cells. Am J Physiol Endocrinol Metab. 2000 Oct; 279(4):E893-9.
    View in: PubMed
  42. Zhou M, Vallega G, Kandror KV, Pilch PF. Insulin-mediated translocation of GLUT-4-containing vesicles is preserved in denervated muscles. Am J Physiol Endocrinol Metab. 2000 Jun; 278(6):E1019-26.
    View in: PubMed
  43. Kandror KV. Insulin regulation of protein traffic in rat adipose cells. J Biol Chem. 1999 Sep 3; 274(36):25210-7.
    View in: PubMed
  44. Thoidis G, Kupriyanova T, Cunningham JM, Chen P, Cadel S, Foulon T, Cohen P, Fine RE, Kandror KV. Glucose transporter Glut3 is targeted to secretory vesicles in neurons and PC12 cells. J Biol Chem. 1999 May 14; 274(20):14062-6.
    View in: PubMed
  45. El-Jack AK, Kandror KV, Pilch PF. The formation of an insulin-responsive vesicular cargo compartment is an early event in 3T3-L1 adipocyte differentiation. Mol Biol Cell. 1999 May; 10(5):1581-94.
    View in: PubMed
  46. Kupriyanova TA, Kandror KV. Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin. J Biol Chem. 1999 Jan 15; 274(3):1458-64.
    View in: PubMed
  47. Kandror KV, Thoidis G. Exploring protein interactions. Trends Endocrinol Metab. 1998 Oct 1; 9(8):343-5.
    View in: PubMed
  48. Zhou M, Sevilla L, Vallega G, Chen P, Palacin M, Zorzano A, Pilch PF, Kandror KV. Insulin-dependent protein trafficking in skeletal muscle cells. Am J Physiol. 1998 Aug; 275(2 Pt 1):E187-96.
    View in: PubMed
  49. Kandror KV, Pilch PF. Multiple endosomal recycling pathways in rat adipose cells. Biochem J. 1998 May 1; 331 ( Pt 3):829-35.
    View in: PubMed
  50. Thoidis G, Chen P, Pushkin AV, Vallega G, Leeman SE, Fine RE, Kandror KV. Two distinct populations of synaptic-like vesicles from rat brain. Proc Natl Acad Sci U S A. 1998 Jan 6; 95(1):183-8.
    View in: PubMed
  51. Lin BZ, Pilch PF, Kandror KV. Sortilin is a major protein component of Glut4-containing vesicles. J Biol Chem. 1997 Sep 26; 272(39):24145-7.
    View in: PubMed
  52. Kandror KV, Pilch PF. The insulin-like growth factor II/mannose 6-phosphate receptor utilizes the same membrane compartments as GLUT4 for insulin-dependent trafficking to and from the rat adipocyte cell surface. J Biol Chem. 1996 Sep 6; 271(36):21703-8.
    View in: PubMed
  53. Kandror KV, Pilch PF. Compartmentalization of protein traffic in insulin-sensitive cells. Am J Physiol. 1996 Jul; 271(1 Pt 1):E1-14.
    View in: PubMed
  54. Tozzo E, Kahn BB, Pilch PF, Kandror KV. Glut4 is targeted to specific vesicles in adipocytes of transgenic mice overexpressing Glut4 selectively in adipose tissue. J Biol Chem. 1996 May 3; 271(18):10490-4.
    View in: PubMed
  55. Coderre L, Kandror KV, Vallega G, Pilch PF. Identification and characterization of an exercise-sensitive pool of glucose transporters in skeletal muscle. J Biol Chem. 1995 Nov 17; 270(46):27584-8.
    View in: PubMed
  56. Kandror KV, Stephens JM, Pilch PF. Expression and compartmentalization of caveolin in adipose cells: coordinate regulation with and structural segregation from GLUT4. J Cell Biol. 1995 May; 129(4):999-1006.
    View in: PubMed
  57. Kandror KV, Coderre L, Pushkin AV, Pilch PF. Comparison of glucose-transporter-containing vesicles from rat fat and muscle tissues: evidence for a unique endosomal compartment. Biochem J. 1995 Apr 15; 307 ( Pt 2):383-90.
    View in: PubMed
  58. Kandror KV, Yu L, Pilch PF. The major protein of GLUT4-containing vesicles, gp160, has aminopeptidase activity. J Biol Chem. 1994 Dec 9; 269(49):30777-80.
    View in: PubMed
  59. Strydom DJ, Kandror K. Identification of actin isoforms after in situ hydroxylamine cleavage on sequencer membranes: serum actin is a cytoplasmic isoform. Biochem Biophys Res Commun. 1994 Nov 30; 205(1):195-201.
    View in: PubMed
  60. Kandror KV, Pilch PF. gp160, a tissue-specific marker for insulin-activated glucose transport. Proc Natl Acad Sci U S A. 1994 Aug 16; 91(17):8017-21.
    View in: PubMed
  61. Kandror K, Pilch PF. Identification and isolation of glycoproteins that translocate to the cell surface from GLUT4-enriched vesicles in an insulin-dependent fashion. J Biol Chem. 1994 Jan 7; 269(1):138-42.
    View in: PubMed
  62. Kandror KV, Stepanov AS. [Informosomes and translation activity of mRNA in eukaryotic cells]. Mol Biol (Mosk). 1988 Jan-Feb; 22(1):31-43.
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  63. Kandror KV, Stepanov AS. [Identification and isolation of casein kinase type II from RNA-binding proteins of amphibian oocytes]. Biokhimiia. 1984 Jun; 49(6):1038-45.
    View in: PubMed
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