Konstantin Kandror | Profiles RNS

Konstantin Kandror, PhD

Emeritus Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, USSR Academy of Sciences
BS, Moscow State University

Websites

	Biochemistry Faculty
	LinkedIn
	ResearchGate

ORCID : 0000-0002-8601-9313

Expertise includes: Insulin action; Adipocyte biology; Membrane traffic.

Adipocytes, skeletal myocytes and some neurons express a specific isoform of the glucose transporter protein, Glut4. Under basal conditions this transporter is localized in intracellular membrane vesicles which fuse with the plasma membrane upon insulin administration. Translocation of Glut4 plays a major role in post-prandial glucose clearance and, more generally, in glucose sensing and metabolic homeostasis in the body. For a number of years, my lab has been involved in the dissection of the “Glut4 pathway” in various insulin-sensitive cells.

Another key physiological function of insulin is to inhibit lipolysis and to promote storage of triglycerides in fat tissue. Recently, we have discovered two novel pathways of regulation of lipolysis by insulin. One of these pathways is mediated by the insulin- and nutrient-sensitive mammalian Target of Rapamycin Complex 1, while the other is mediated by transcriptional factor FoxO1. Currently, we are engaged in the dissection of both pathways at the molecular level.

Fat represents an important secretory tissue in the body. Unlike typical endocrine and exocrine cells, adipocytes produce and secret several physiologically important proteins, such as leptin, adiponectin, lipoprotein lipase, etc. and switch the secretory process from one protein to another in response to changing metabolic conditions. We are exploring connections between food intake, obesity and secretion of adipokines in order to understand the central role of fat tissue in the orchestrating the overall response of the organism to changing metabolic conditions.

Insulin Regulation of Cell Nutrition
03/06/2020 - 02/29/2024 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK052057-23

Regulation of leptin production by mTORC1
01/01/2018 - 06/30/2021 (PI)
American Diabetes Association

Regulation of Lipolysis by mTORC1
02/10/2016 - 01/31/2021 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK107498-04

Insulin Regulation of Cell Nutrition
09/01/2015 - 02/29/2020 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK052057-19

Boston Nutrition Obesity Research Center
07/01/2017 - 05/31/2018 (Key Person / Mentor)
Boston Medical Center Corporation NIH NIDDK
5P30DK046200-25

Reprogramming Fatty Acid handling to improve adipocyte function in human obesity
07/01/2016 - 12/31/2017 (Subcontract PI)
Icahn School of Medicine at Mount Sinai Amer Diabetes Assoc

Cide Proteins and Regulation of Energy Expenditure
09/01/2015 - 08/31/2017 (Subcontract PI)
Ohio University NIH NIDDK
7R01DK101711-03

Reprogramming Fatty Acid handling to improve adipocyte function in human obesity
01/01/2015 - 06/30/2016 (Subcontract PI)
Boston Medical Center Corporation Amer Diabetes Assoc

Insulin Regulation of Cell Nutrition
08/25/2014 - 08/31/2015 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
2R56DK052057-16

Insulin Regulation of Cell Nutrition
06/01/2008 - 08/24/2014 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK052057-15

Showing 10 of 19 results. Show All Results

Metabolism, Endocrinology & Obesity Training Grant
07/01/2014 - 06/30/2024 (Multi-PI)
PI: Konstantin Kandror, PhD
National Institutes of Health/DHHS/NIH
2T32DK007201-37

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Metabolism, Endocrinology, and Obesity Training Grant	5T32DK007201-46
2023	Insulin regulation of cell nutrition	5R01DK052057-23
2022	Metabolism, Endocrinology, and Obesity Training Grant	5T32DK007201-45
2022	Insulin regulation of cell nutrition	5R01DK052057-22
2021	Metabolism, Endocrinology, and Obesity Training Grant	5T32DK007201-44	75
2021	Insulin regulation of cell nutrition	5R01DK052057-21	48
2020	Metabolism, Endocrinology, and Obesity Training Grant	5T32DK007201-43	75
2020	Insulin regulation of cell nutrition	2R01DK052057-20A1	48
2019	Regulation of lipolysis by mTORC1	5R01DK107498-04	4
2019	Metabolism, Endocrinology, and Obesity Training Grant	2T32DK007201-42	75

Showing 10 of 52 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Zaarur N, Meriin AB, Singh M, Goel RK, Zaia J, Kandror KV. Akt may associate with insulin-responsive vesicles via interaction with sortilin. FEBS Lett. 2024 Feb; 598(4):390-399.View Related Profiles.

Meriin, Anatoli
Zaia, Joseph
Kandror, Konstantin
Zaarur, Nava
Goel, Raghuveera

PMID: 38105115; PMCID: PMC10922807; DOI: 10.1002/1873-3468.14790;

Lotfollahzadeh S, Xia C, Amraei R, Hua N, Kandror KV, Farmer SR, Wei W, Costello CE, Chitalia V, Rahimi N. Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity. Mol Metab. 2023 Jul; 73:101744.View Related Profiles.

Costello, Catherine
Kandror, Konstantin
Rahimi, Nader
Hua, Ning
Lotfollahzadeh, Saran
Farmer, Stephen
Chitalia, Vipul

PMID: 37245847; PMCID: PMC10267597; DOI: 10.1016/j.molmet.2023.101744;

Meriin AB, Zaarur N, Roy D, Kandror KV. Egr1 plays a major role in the transcriptional response of white adipocytes to insulin and environmental cues. Front Cell Dev Biol. 2022; 10:1003030.View Related Profiles.

Meriin, Anatoli
Kandror, Konstantin
Zaarur, Nava

PMID: 36246998; PMCID: PMC9554007; DOI: 10.3389/fcell.2022.1003030;

Meriin AB, Zaarur N, Bogan JS, Kandror KV. Inhibitors of RNA and protein synthesis cause Glut4 translocation and increase glucose uptake in adipocytes. Sci Rep. 2022 Sep 19; 12(1):15640.View Related Profiles.

Meriin, Anatoli
Kandror, Konstantin
Zaarur, Nava

PMID: 36123369; PMCID: PMC9485115; DOI: 10.1038/s41598-022-19534-5;

Zaarur N, Desevin K, Mackenzie J, Lord A, Grishok A, Kandror KV. ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans. Mol Metab. 2019 09; 27:75-82.View Related Profiles.

Grishok, Alla
Kandror, Konstantin
Zaarur, Nava

PMID: 31311719; PMCID: PMC6717769; DOI: 10.1016/j.molmet.2019.07.001;

Pan X, Meriin A, Huang G, Kandror KV. Insulin-responsive amino peptidase follows the Glut4 pathway but is dispensable for the formation and translocation of insulin-responsive vesicles. Mol Biol Cell. 2019 06 01; 30(12):1536-1543.View Related Profiles.

Meriin, Anatoli
Kandror, Konstantin
Pan, Xiang

PMID: 30943117; PMCID: PMC6724691; DOI: 10.1091/mbc.E18-12-0792;

Mohtar O, Ozdemir C, Roy D, Shantaram D, Emili A, Kandror KV. Egr1 mediates the effect of insulin on leptin transcription in adipocytes. J Biol Chem. 2019 04 12; 294(15):5784-5789.View Related Profiles.

Emili, Andrew
Roy, Debasish
Kandror, Konstantin
Mohtar, Omar

PMID: 30846562; PMCID: PMC6463691; DOI: 10.1074/jbc.AC119.007855;

Zaarur N, Pan X, Kandror KV. Detection of Detergent-sensitive Interactions Between Membrane Proteins. J Vis Exp. 2018 03 07; (133).View Related Profiles.

Kandror, Konstantin
Zaarur, Nava
Pan, Xiang

PMID: 29578521; PMCID: PMC5931480; DOI: 10.3791/57179;

Boesze-Battaglia K, Walker LP, Dhingra A, Kandror K, Tang HY, Shenker BJ. Internalization of the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1. Front Cell Infect Microbiol. 2017; 7:469. PMID: 29184850; PMCID: PMC5694546; DOI: 10.3389/fcimb.2017.00469;

Kandror KV. Mammalian target of rapamycin complex 1 and FoxO1 in the transcriptional control of lipolysis and de novo lipogenesis. Curr Opin Endocrinol Diabetes Obes. 2017 Oct; 24(5):326-331. PMID: 28841634

Showing 10 of 100 results. Show More

Pan X, Zaarur N, Singh M, Morin P, Kandror KV. Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes. Mol Biol Cell. 2017 Jun 15; 28(12):1667-1675.View Related Profiles.

Kandror, Konstantin
Zaarur, Nava
Morin, Peter
Pan, Xiang

PMID: 28450454; PMCID: PMC5469609; DOI: 10.1091/mbc.E16-11-0777;

Kandror KV. The Role of Sortilin in the “Glut4 Pathway”. Communicative & integrative biology. 2017; 11(1). View Publication

Chakrabarti P, Kandror KV. The role of mTOR in lipid homeostasis and diabetes progression. Curr Opin Endocrinol Diabetes Obes. 2015 Oct; 22(5):340-6.View Related Profiles.

Kandror, Konstantin
Chakrabarti, Partha

PMID: 26241026; DOI: 10.1097/MED.0000000000000187;

Singh M, Shin YK, Yang X, Zehr B, Chakrabarti P, Kandror KV. 4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL. J Biol Chem. 2015 Jul 10; 290(28):17331-8.View Related Profiles.

Kandror, Konstantin
Chakrabarti, Partha
Yang, Xiaoqing

PMID: 25814662; PMCID: PMC4498071; DOI: 10.1074/jbc.M114.631895;

Singh M, Kaur R, Lee MJ, Pickering RT, Sharma VM, Puri V, Kandror KV. Fat-specific protein 27 inhibits lipolysis by facilitating the inhibitory effect of transcription factor Egr1 on transcription of adipose triglyceride lipase. J Biol Chem. 2014 May 23; 289(21):14481-7.View Related Profiles.

Kandror, Konstantin
Pickering, Richard
Puri, Vishwajeet

PMID: 24742676; PMCID: PMC4031504; DOI: 10.1074/jbc.C114.563080;

Huang G, Buckler-Pena D, Nauta T, Singh M, Asmar A, Shi J, Kim JY, Kandror KV. Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin. Mol Biol Cell. 2013 Oct; 24(19):3115-22. PMID: 23966466; PMCID: PMC3784384; DOI: 10.1091/mbc.E12-10-0765;

Chakrabarti P, Kim JY, Singh M, Shin YK, Kim J, Kumbrink J, Wu Y, Lee MJ, Kirsch KH, Fried SK, Kandror KV. Insulin inhibits lipolysis in adipocytes via the evolutionarily conserved mTORC1-Egr1-ATGL-mediated pathway. Mol Cell Biol. 2013 Sep; 33(18):3659-66.View Related Profiles.

Kumbrink, Joerg
Kirsch, Kathrin
Kandror, Konstantin
Chakrabarti, Partha
Fried, Susan
Wu, Yuanyuan

PMID: 23858058; PMCID: PMC3753874; DOI: 10.1128/MCB.01584-12;

Kim JY, Kandror KV. The first luminal loop confers insulin responsiveness to glucose transporter 4. Mol Biol Cell. 2012 Mar; 23(5):910-7. PMID: 22262463; PMCID: PMC3290648; DOI: 10.1091/mbc.E11-10-0839;

Karki S, Chakrabarti P, Huang G, Wang H, Farmer SR, Kandror KV. The multi-level action of fatty acids on adiponectin production by fat cells. PLoS One. 2011; 6(11):e28146.View Related Profiles.

Kandror, Konstantin
Chakrabarti, Partha
Karki, Shakun
Farmer, Stephen

PMID: 22140527; PMCID: PMC3226650; DOI: 10.1371/journal.pone.0028146;

Chakrabarti P, English T, Karki S, Qiang L, Tao R, Kim J, Luo Z, Farmer SR, Kandror KV. SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL. J Lipid Res. 2011 Sep; 52(9):1693-701.View Related Profiles.

Kandror, Konstantin
Chakrabarti, Partha
Karki, Shakun
Farmer, Stephen
Luo, Zhijun

PMID: 21743036; PMCID: PMC3151689; DOI: 10.1194/jlr.M014647;

Chakrabarti P, Kandror KV. Adipose triglyceride lipase: a new target in the regulation of lipolysis by insulin. Curr Diabetes Rev. 2011 Jul; 7(4):270-7.View Related Profiles.

Kandror, Konstantin
Chakrabarti, Partha

PMID: 21644917

Kandror KV, Pilch PF. The sugar is sIRVed: sorting Glut4 and its fellow travelers. Traffic. 2011 Jun; 12(6):665-71.View Related Profiles.

Year	Publications
1982	2
1983	1
1984	3
1988	3
1989	2
1990	4
1991	2
1992	3
1993	1
1994	5
1995	3
1996	5
1997	1
1998	4
1999	4
2000	4
2001	3
2002	3
2003	2
2004	5
2005	2
2006	3
2007	2
2008	4
2009	5
2010	2
2011	4
2012	1
2013	2
2014	1
2015	2
2017	4
2018	1
2019	3
2022	2
2023	2