Keywords
Last Name

Alla Grishok, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address72 E. Concord St Silvio Conte (K)
Boston MA
 Research Expertise & Professional Interests
Gene regulation by RNA and chromatin

Research in the Grishok laboratory utilizes the nematode Caenorhabditis elegans and focuses on new mechanisms of gene regulation by short RNAs and chromatin-modifying complexes. Model organisms, such as C. elegans, are best suited for basic science. Importantly, discoveries made in basic research have the potential to affect translational science and the biotech industry in often-unpredictable ways.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Cecere G, Hoersch S, O'Keeffe S, Sachidanandam R, Grishok A. Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape. Nat Struct Mol Biol. 2014 Apr; 21(4):358-65. PMID: 24681887.
    View in: PubMed
  2. Kennedy LM, Grishok A. Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans. Genetics. 2014 May; 197(1):207-20. PMID: 24558261.
    View in: PubMed
  3. Cecere G, Grishok A. A nuclear perspective on RNAi pathways in metazoans. Biochim Biophys Acta. 2014 Mar; 1839(3):223-33. PMID: 24361586.
    View in: PubMed
  4. Kennedy LM, Pham SC, Grishok A. Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1. Cell Rep. 2013 Sep 12; 4(5):996-1009. PMID: 23994474.
    View in: PubMed
  5. Cecere G, Hoersch S, Jensen MB, Dixit S, Grishok A. The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription. Mol Cell. 2013 Jun 27; 50(6):894-907. PMID: 23806335.
    View in: PubMed
  6. Grishok A. Biology and Mechanisms of Short RNAs in Caenorhabditis elegans. Adv Genet. 2013; 83:1-69. PMID: 23890211.
    View in: PubMed
  7. Avgousti DC, Cecere G, Grishok A. The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans. Mol Cell Biol. 2013 Mar; 33(5):999-1015. PMID: 23263989.
    View in: PubMed
  8. Avgousti DC, Palani S, Sherman Y, Grishok A. CSR-1 RNAi pathway positively regulates histone expression in C. elegans. EMBO J. 2012 Oct 3; 31(19):3821-32. PMID: 22863779.
    View in: PubMed
  9. Cecere G, Zheng GX, Mansisidor AR, Klymko KE, Grishok A. Promoters recognized by forkhead proteins exist for individual 21U-RNAs. Mol Cell. 2012 Sep 14; 47(5):734-45. PMID: 22819322.
    View in: PubMed
  10. Grishok A. Endogenous RNAi and adaptation to environment in C. elegans. Worm. 2012 Apr 1; 1(2):129-33. PMID: 24058837.
    View in: PubMed
  11. Mansisidor AR, Cecere G, Hoersch S, Jensen MB, Kawli T, Kennedy LM, Chavez V, Tan MW, Lieb JD, Grishok A. A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans. PLoS Genet. 2011 Sep; 7(9):e1002299. PMID: 21980302.
    View in: PubMed
  12. Grishok A, Hoersch S, Sharp PA. RNA interference and retinoblastoma-related genes are required for repression of endogenous siRNA targets in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20386-91. PMID: 19073934.
    View in: PubMed
  13. Grishok A, Sharp PA. Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17360-5. PMID: 16287966.
    View in: PubMed
  14. Grishok A. RNAi mechanisms in Caenorhabditis elegans. FEBS Lett. 2005 Oct 31; 579(26):5932-9. PMID: 16162338.
    View in: PubMed
  15. Grishok A, Sinskey JL, Sharp PA. Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes Dev. 2005 Mar 15; 19(6):683-96. PMID: 15741313.
    View in: PubMed
  16. Grishok A, Mello CC. RNAi (Nematodes: Caenorhabditis elegans). Adv Genet. 2002; 46:339-60. PMID: 11931230.
    View in: PubMed
  17. Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001 Jul 13; 106(1):23-34. PMID: 11461699.
    View in: PubMed
  18. Grishok A, Tabara H, Mello CC. Genetic requirements for inheritance of RNAi in C. elegans. Science. 2000 Mar 31; 287(5462):2494-7. PMID: 10741970.
    View in: PubMed
  19. Tabara H, Sarkissian M, Kelly WG, Fleenor J, Grishok A, Timmons L, Fire A, Mello CC. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell. 1999 Oct 15; 99(2):123-32. PMID: 10535731.
    View in: PubMed
  20. Tabara H, Grishok A, Mello CC. RNAi in C. elegans: soaking in the genome sequence. Science. 1998 Oct 16; 282(5388):430-1. PMID: 9841401.
    View in: PubMed
  21. Neitz M, Neitz J, Grishok A. Polymorphism in the number of genes encoding long-wavelength-sensitive cone pigments among males with normal color vision. Vision Res. 1995 Sep; 35(17):2395-407. PMID: 8594809.
    View in: PubMed
  22. Grishok A. Extracellular nucleic acids as possible messengers in regulatory information transfer from immune system to non-lymphoid tissues. Med Hypotheses. 1995 Jun; 44(6):435-8. PMID: 7476586.
    View in: PubMed
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