Alla Grishok | Profiles RNS

Alla Grishok, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, University of Massachusetts Medical School
BS, Kiev Taras Shevchenko University

Websites

	Biochemistry Faculty
	BUSM
	Google Scholar
	Linkedin
	Research Gate

ORCID : 0000-0001-8922-7575

Gene regulation by RNA and chromatin

Research in the Grishok laboratory utilizes the nematode Caenorhabditis elegans and focuses on new mechanisms of gene regulation by short RNAs and chromatin-modifying complexes. Model organisms, such as C. elegans, are best suited for basic science. Importantly, discoveries made in basic research have the potential to affect translational science and the biotech industry in often-unpredictable ways.

Co-Director
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Investigate double-stranded RNA-derived small RNAs and their targets affecting C. elegans lifespan
04/01/2024 - 03/31/2026 (PI)
Hevolution Foundation

The role of DOT1L methyltransferase in controlling the noncoding transcriptome
08/01/2020 - 07/31/2025 (PI)
NIH/National Institute of General Medical Sciences
5R01GM135199-04

Molecular mechanisms of translational regulation in aging
04/01/2019 - 01/31/2025 (Key Person)
PI: Vyacheslav Labunskyy, PhD
NIH/National Institute on Aging
5R01AG058713-05

Regulation of RNA Processing and Transcription by Endogenous RNAi
04/01/2016 - 03/31/2018 (PI)
NIH/National Institute of General Medical Sciences
5R01GM107056-04

Title

Yr	Title	Project-Sub Proj	Pubs
2023	The role of DOT1L methyltransferase in controlling the noncoding transcriptome	3R01GM135199-03S1
2023	The role of DOT1L methyltransferase in controlling the noncoding transcriptome	5R01GM135199-04
2022	The role of DOT1L methyltransferase in controlling the noncoding transcriptome	3R01GM135199-02S1
2022	The role of DOT1L methyltransferase in controlling the noncoding transcriptome	5R01GM135199-03
2021	The role of DOT1L methyltransferase in controlling the noncoding transcriptome	5R01GM135199-02
2020	The role of DOT1L methyltransferase in controlling the noncoding transcriptome	1R01GM135199-01A1
2017	Regulation of RNA processing and transcription by endogenous RNAi	5R01GM107056-04	2
2016	Regulation of RNA processing and transcription by endogenous RNAi	7R01GM107056-03	2
2015	Regulation of RNA processing and transcription by endogenous RNAi	5R01GM107056-02	2
2014	Regulation of RNA processing and transcription by endogenous RNAi	1R01GM107056-01A1	2

Showing 10 of 11 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Sepulveda GP, Gushchanskaia ES, Mora-Martin A, Esse R, Nikorich I, Ceballos A, Kwan J, Blum BC, Dholiya P, Emili A, Perissi V, Cardamone MD, Grishok A. DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin. bioRxiv. 2024 Feb 07.View Related Profiles.

Grishok, Alla
Blum, Benjamin
Gushchanskaia, Ekaterina
Sepulveda, Gian
Perissi, Valentina

PMID: 38370658; PMCID: PMC10871221; DOI: 10.1101/2024.02.06.579191;

Liontis T, Verma K, Grishok A. DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation. BBA Adv. 2023; 3:100080. PMID: 37082252; PMCID: PMC10074844; DOI: 10.1016/j.bbadva.2023.100080;

Farley SJ, Grishok A, Zeldich E. Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain. Epigenetics Chromatin. 2022 Dec 03; 15(1):39.View Related Profiles.

Grishok, Alla
Zeldich, Ella

PMID: 36463299; PMCID: PMC9719135; DOI: 10.1186/s13072-022-00471-6;

Ceballos A, Esse R, Grishok A. The proline-rich domain of MML-1 is biologically important but not required for localization to target promoters. MicroPubl Biol. 2021; 2021. PMID: 34778725; PMCID: PMC8579147; DOI: 10.17912/micropub.biology.000498;

Grishok A. Small RNAs Worm Up Transgenerational Epigenetics Research. DNA (Basel). 2021 Dec; 1(2):37-48. PMID: 34725653; PMCID: PMC8556531; DOI: 10.3390/dna1020005;

Lascarez-Lagunas LI, Herruzo E, Grishok A, San-Segundo PA, Colaiácovo MP. DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans. PLoS Genet. 2020 10; 16(10):e1009171. PMID: 33104701; PMCID: PMC7644094; DOI: 10.1371/journal.pgen.1009171;

Esse R, Grishok A. Caenorhabditis elegans Deficient in DOT-1.1 Exhibit Increases in H3K9me2 at Enhancer and Certain RNAi-Regulated Regions. Cells. 2020 08 06; 9(8). PMID: 32781660; PMCID: PMC7464606; DOI: 10.3390/cells9081846;

Esse R, Gushchanskaia ES, Lord A, Grishok A. DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi in Caenorhabditis elegans. RNA. 2019 10; 25(10):1259-1273.View Related Profiles.

Grishok, Alla
Gushchanskaia, Ekaterina

PMID: 31300558; PMCID: PMC6800474; DOI: 10.1261/rna.070292.119;

Zaarur N, Desevin K, Mackenzie J, Lord A, Grishok A, Kandror KV. ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans. Mol Metab. 2019 09; 27:75-82.View Related Profiles.

Grishok, Alla
Kandror, Konstantin
Zaarur, Nava

PMID: 31311719; PMCID: PMC6717769; DOI: 10.1016/j.molmet.2019.07.001;

Gushchanskaia ES, Esse R, Ma Q, Lau NC, Grishok A. Interplay between small RNA pathways shapes chromatin landscapes in C. elegans. Nucleic Acids Res. 2019 06 20; 47(11):5603-5616.View Related Profiles.

Grishok, Alla
Gushchanskaia, Ekaterina
Lau, Nelson

PMID: 31216042; PMCID: PMC6582410; DOI: 10.1093/nar/gkz275;

Showing 10 of 29 results. Show More

Cecere G, Grishok A. RNA Chromatin Immunoprecipitation (RNA-ChIP) in Caenorhabditis elegans. Bio Protoc. 2014 Dec 20; 4(24). PMID: 29170745; PMCID: PMC5697774; DOI: 10.21769/BioProtoc.1358;

Cecere G, Hoersch S, O'Keeffe S, Sachidanandam R, Grishok A. Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape. Nat Struct Mol Biol. 2014 Apr; 21(4):358-65. PMID: 24681887; PMCID: PMC4068146; DOI: 10.1038/nsmb.2801;

Kennedy LM, Grishok A. Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans. Genetics. 2014 May; 197(1):207-20. PMID: 24558261; PMCID: PMC4012481; DOI: 10.1534/genetics.114.162917;

Cecere G, Grishok A. A nuclear perspective on RNAi pathways in metazoans. Biochim Biophys Acta. 2014 Mar; 1839(3):223-33. PMID: 24361586; PMCID: PMC3951611; DOI: 10.1016/j.bbagrm.2013.11.009;

Kennedy LM, Pham SC, Grishok A. Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1. Cell Rep. 2013 Sep 12; 4(5):996-1009. PMID: 23994474; PMCID: PMC3800683; DOI: 10.1016/j.celrep.2013.07.045;

Cecere G, Hoersch S, Jensen MB, Dixit S, Grishok A. The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription. Mol Cell. 2013 Jun 27; 50(6):894-907. PMID: 23806335; PMCID: PMC3784254; DOI: 10.1016/j.molcel.2013.06.002;

Grishok A. Biology and Mechanisms of Short RNAs in Caenorhabditis elegans. Adv Genet. 2013; 83:1-69. PMID: 23890211; DOI: 10.1016/B978-0-12-407675-4.00001-8;

Avgousti DC, Cecere G, Grishok A. The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans. Mol Cell Biol. 2013 Mar; 33(5):999-1015. PMID: 23263989; PMCID: PMC3623080; DOI: 10.1128/MCB.01462-12;

Avgousti DC, Palani S, Sherman Y, Grishok A. CSR-1 RNAi pathway positively regulates histone expression in C. elegans. EMBO J. 2012 Oct 3; 31(19):3821-32. PMID: 22863779; PMCID: PMC3463841; DOI: 10.1038/emboj.2012.216;

Cecere G, Zheng GX, Mansisidor AR, Klymko KE, Grishok A. Promoters recognized by forkhead proteins exist for individual 21U-RNAs. Mol Cell. 2012 Sep 14; 47(5):734-45. PMID: 22819322; PMCID: PMC3444671; DOI: 10.1016/j.molcel.2012.06.021;

Grishok A. Endogenous RNAi and adaptation to environment in C. elegans. Worm. 2012 Apr 1; 1(2):129-33. PMID: 24058837; PMCID: PMC3670229; DOI: 10.4161/worm.19538;

Mansisidor AR, Cecere G, Hoersch S, Jensen MB, Kawli T, Kennedy LM, Chavez V, Tan MW, Lieb JD, Grishok A. A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans. PLoS Genet. 2011 Sep; 7(9):e1002299. PMID: 21980302; PMCID: PMC3183084; DOI: 10.1371/journal.pgen.1002299;

Grishok A, Hoersch S, Sharp PA. RNA interference and retinoblastoma-related genes are required for repression of endogenous siRNA targets in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20386-91. PMID: 19073934; PMCID: PMC2629315; DOI: 10.1073/pnas.0810589105;

Grishok A, Sharp PA. Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17360-5. PMID: 16287966; PMCID: PMC1297700; DOI: 10.1073/pnas.0508989102;

Grishok A. RNAi mechanisms in Caenorhabditis elegans. FEBS Lett. 2005 Oct 31; 579(26):5932-9. PMID: 16162338

Grishok A, Sinskey JL, Sharp PA. Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes Dev. 2005 Mar 15; 19(6):683-96. PMID: 15741313; PMCID: PMC1065722; DOI: 10.1101/gad.1247705;

Grishok A, Mello CC. RNAi (Nematodes: Caenorhabditis elegans). Adv Genet. 2002; 46:339-60. PMID: 11931230

Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell. 2001 Jul 13; 106(1):23-34. PMID: 11461699

Neitz M, Neitz J, Grishok A. Polymorphism in the number of genes encoding long-wavelength-sensitive cone pigments among males with normal color vision. Vision Res. 1995 Sep; 35(17):2395-407. PMID: 8594809

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 29 publications over 15 distinct years, with a maximum of 4 publications in 2012 and 2013

Bar chart showing 29 publications over 15 distinct years, with a maximum of 4 publications in 2012 and 2013

Year	Publications
1995	1
2001	1
2002	1
2005	3
2008	1
2011	1
2012	4
2013	4
2014	3
2019	3
2020	2
2021	2
2022	1
2023	1
2024	1

Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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617.358.4525

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