Vyacheslav Labunskyy, PhD
Associate Professor
Boston University School of Medicine
Dept of Dermatology

PhD, University of Nebraska
MS, Donetsk National University

The primary research focus of our lab is the biology of aging and understanding the basic mechanisms that underlie the pathogenesis of age-related diseases. We are particularly interested in studying the nature of senescence factors and understanding how stress response signaling regulates aging. In our work we utilize ribosome profiling and next-generation sequencing, and a combination of molecular and biochemical approaches to look at transcriptional and translational changes that are associated with the aging process as well as the mechanisms of such regulation in eukaryotic cells. A second major focus of the laboratory is synthetic biology and developing new bioengineering approaches that can be used to study complex traits, such as longevity, using yeast S. cerevisiae as a model organism.

We hope that our studies will provide a better understanding of the mechanisms that regulate aging and will help to identify new targets for therapeutic intervention for age-related diseases.

Assistant Professor
Boston University School of Medicine

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

Molecular mechanisms of translational regulation in aging
04/01/2019 - 01/31/2024 (PI)
NIH/National Institute on Aging

The role of iron homeostasis in aging
09/30/2021 - 08/31/2022 (PI)
NIH/National Institute on Aging

Molecular mechanisms of translational regulation in aging
09/30/2017 - 08/31/2019 (PI)
NIH/National Institute on Aging

ER stress resistance and longevity
07/01/2017 - 06/30/2018 (PI)
American Federation for Aging Research

Endoplasmic Reticulum Thiol Redox State and Unfolded Protein Response in Aging
09/30/2014 - 04/30/2018 (PI)
NIH/National Institute on Aging


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Barlit H, Rai MK, Shoushtari SI, Beaupere C, Labunskyy VM. Genome-Wide Analysis of Translation in Replicatively Aged Yeast. Methods Mol Biol. 2021; 2252:151-173.View Related Profiles. PMID: 33765274; PMCID: PMC8565997; DOI: 10.1007/978-1-0716-1150-0_6;
  2. Beaupere C, Labunskyy VM. (Un)folding mechanisms of adaptation to ER stress: lessons from aneuploidy. Curr Genet. 2019 Apr; 65(2):467-471. PMID: 30511161; PMCID: PMC6421085; DOI: 10.1007/s00294-018-0914-9;
  3. Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):9586-9591. PMID: 30185560; PMCID: PMC6156608; DOI: 10.1073/pnas.1804264115;
  4. Beaupere C, Chen RB, Pelosi W, Labunskyy VM. Genome-wide Quantification of Translation in Budding Yeast by Ribosome Profiling. J Vis Exp. 2017 12 21; (130). PMID: 29286414; PMCID: PMC5755679; DOI: 10.3791/56820;
  5. Lorusso JS, Sviderskiy OA, Labunskyy VM. Emerging Omics Approaches in Aging Research. Antioxid Redox Signal. 2018 10 01; 29(10):985-1002. PMID: 28874057; PMCID: PMC6104250; DOI: 10.1089/ars.2017.7163;
  6. Beaupere C, Wasko BM, Lorusso J, Kennedy BK, Kaeberlein M, Labunskyy VM. CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell Rep. 2017 Feb 21; 18(8):1884-1892. PMID: 28228255; PMCID: PMC5327506; DOI: 10.1016/j.celrep.2017.01.077;
  7. Gao J, Barroso C, Zhang P, Kim HM, Li S, Labrador L, Lightfoot J, Gerashchenko MV, Labunskyy VM, Dong MQ, Martinez-Perez E, Colaiácovo MP. N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Genes Dev. 2016 Nov 01; 30(21):2404-2416. PMID: 27881602; PMCID: PMC5131780; DOI: 10.1101/gad.277350.116;
  8. Labunskyy VM, Hatfield DL, Gladyshev VN. Selenoproteins: molecular pathways and physiological roles. Physiol Rev. 2014 Jul; 94(3):739-77. PMID: 24987004; PMCID: PMC4101630; DOI: 10.1152/physrev.00039.2013;
  9. Labunskyy VM, Suzuki Y, Hanly TJ, Murao A, Roth FP, Gladyshev VN. The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast. G3 (Bethesda). 2014 Jul; 4(7):1183-91. PMID: 24776987; PMCID: PMC4455768; DOI: 10.1534/g3.114.010868;
  10. Labunskyy VM, Gerashchenko MV, Delaney JR, Kaya A, Kennedy BK, Kaeberlein M, Gladyshev VN. Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. PLoS Genet. 2014 Jan; 10(1):e1004019. PMID: 24391512; PMCID: PMC3879150; DOI: 10.1371/journal.pgen.1004019;
Showing 10 of 23 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 23 publications over 12 distinct years, with a maximum of 3 publications in 2005 and 2009 and 2011 and 2014 and 2017

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Functional Genomics
Molecular Mechanisms of Skin Aging
Stress Signaling
Synthetic Biology
Contact for Mentoring:

609 Albany St (J Bldg)
Boston MA 02118
Google Map

Labunskyy's Networks
Click the "See All" links for more information and interactive visualizations
Media Mentions
Similar People
Same Department