Vyacheslav Labunskyy, PhD
Assistant Professor
Boston University School of Medicine
Dept of Dermatology

MS, Donetsk State Medical University
PhD, University of Nebraska



The primary research focus of our lab is the biology of aging and understanding the basic mechanisms that underlie the pathogenesis of age-related diseases. We are particularly interested in studying the nature of senescence factors and understanding how stress response signaling regulates aging. In our work we utilize ribosome profiling and next-generation sequencing, and a combination of molecular and biochemical approaches to look at transcriptional and translational changes that are associated with the aging process as well as the mechanisms of such regulation in eukaryotic cells. A second major focus of the laboratory is synthetic biology and developing new bioengineering approaches that can be used to study complex traits, such as longevity, using yeast S. cerevisiae as a model organism.

We hope that our studies will provide a better understanding of the mechanisms that regulate aging and will help to identify new targets for therapeutic intervention for age-related diseases.


Endoplasmic Reticulum Thiol Redox State and Unfolded Protein Response in Aging
09/30/2014 - 04/30/2018 (PI)
NIH/National Institute on Aging
5R00AG040191-05



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Beaupere C, Wasko BM, Lorusso J, Kennedy BK, Kaeberlein M, Labunskyy VM. CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell Rep. 2017 Feb 21; 18(8):1884-1892. PMID: 28228255; DOI: 10.1016/j.celrep.2017.01.077;.
  2. Gao J, Barroso C, Zhang P, Kim HM, Li S, Labrador L, Lightfoot J, Gerashchenko MV, Labunskyy VM, Dong MQ, Martinez-Perez E, Colaiácovo MP. N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Genes Dev. 2016 Nov 01; 30(21):2404-2416. PMID: 27881602.
  3. Labunskyy VM, Hatfield DL, Gladyshev VN. Selenoproteins: molecular pathways and physiological roles. Physiol Rev. 2014 Jul; 94(3):739-77. PMID: 24987004; PMCID: PMC4101630; DOI: 10.1152/physrev.00039.2013;.
  4. Labunskyy VM, Suzuki Y, Hanly TJ, Murao A, Roth FP, Gladyshev VN. The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast. G3 (Bethesda). 2014 Jul; 4(7):1183-91. PMID: 24776987; PMCID: PMC4455768; DOI: 10.1534/g3.114.010868;.
  5. Labunskyy VM, Gerashchenko MV, Delaney JR, Kaya A, Kennedy BK, Kaeberlein M, Gladyshev VN. Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. PLoS Genet. 2014 Jan; 10(1):e1004019. PMID: 24391512; PMCID: PMC3879150; DOI: 10.1371/journal.pgen.1004019;.
  6. Labunskyy VM, Gladyshev VN. Role of reactive oxygen species-mediated signaling in aging. Antioxid Redox Signal. 2013 Oct 20; 19(12):1362-72. PMID: 22901002; PMCID: PMC3791051; DOI: 10.1089/ars.2012.4891;.
  7. Kasaikina MV, Fomenko DE, Labunskyy VM, Lachke SA, Qiu W, Moncaster JA, Zhang J, Wojnarowicz MW, Natarajan SK, Malinouski M, Schweizer U, Tsuji PA, Carlson BA, Maas RL, Lou MF, Goldstein LE, Hatfield DL, Gladyshev VN. Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice. J Biol Chem. 2011 Sep 23; 286(38):33203-12.View Related Profiles. PMID: 21768092; PMCID: PMC3190948; DOI: 10.1074/jbc.M111.259218;.
  8. Labunskyy VM, Lee BC, Handy DE, Loscalzo J, Hatfield DL, Gladyshev VN. Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. Antioxid Redox Signal. 2011 Jun 15; 14(12):2327-36. PMID: 21194350; PMCID: PMC3096499; DOI: 10.1089/ars.2010.3526;.
  9. Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehár J, Roth FP. Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection. Nat Methods. 2011 Feb; 8(2):159-64. PMID: 21217751; PMCID: PMC3076670; DOI: 10.1038/nmeth.1550;.
  10. Shchedrina VA, Zhang Y, Labunskyy VM, Hatfield DL, Gladyshev VN. Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins. Antioxid Redox Signal. 2010 Apr 1; 12(7):839-49. PMID: 19747065; PMCID: PMC2864662; DOI: 10.1089/ars.2009.2865;.
Showing 10 of 18 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 18 publications over 10 distinct years, with a maximum of 3 publications in 2005 and 2009 and 2011 and 2014

YearPublications
20031
20053
20071
20093
20101
20113
20121
20143
20161
20171
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Functional Genomics
Molecular Mechanisms of Skin Aging
Stress Signaling
Synthetic Biology
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609 Albany St (J Bldg)
Boston MA 02118
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