Vyacheslav Labunskyy | Profiles RNS

Vyacheslav Labunskyy, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Dermatology

PhD, University of Nebraska
MS, Donetsk National University
BS, Donetsk National University

Websites

	Labunskyy Lab website
	LinkedIn
	ResearchGate
	Google Scholar

ORCID : 0000-0001-9317-1076

The primary research focus of our lab is the biology of aging and understanding the basic mechanisms that underlie the pathogenesis of age-related diseases. We are particularly interested in studying the nature of senescence factors and understanding how stress response signaling regulates aging. In our work we utilize ribosome profiling and next-generation sequencing, and a combination of molecular and biochemical approaches to look at transcriptional and translational changes that are associated with the aging process as well as the mechanisms of such regulation in eukaryotic cells. A second major focus of the laboratory is synthetic biology and developing new bioengineering approaches that can be used to study complex traits, such as longevity, using yeast S. cerevisiae as a model organism.

We hope that our studies will provide a better understanding of the mechanisms that regulate aging and will help to identify new targets for therapeutic intervention for age-related diseases.

Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Molecular mechanisms of translational regulation in aging
04/01/2019 - 01/31/2024 (PI)
NIH/National Institute on Aging
5R01AG058713-05

The role of iron homeostasis in aging
09/30/2021 - 08/31/2023 (PI)
NIH/National Institute on Aging
1R56AG066704-01A1

Molecular mechanisms of translational regulation in aging
09/30/2017 - 08/31/2019 (PI)
NIH/National Institute on Aging
3R56AG054566-01A1S1

ER stress resistance and longevity
07/01/2017 - 06/30/2018 (PI)
American Federation for Aging Research

Endoplasmic Reticulum Thiol Redox State and Unfolded Protein Response in Aging
09/30/2014 - 04/30/2018 (PI)
NIH/National Institute on Aging
5R00AG040191-05

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Molecular mechanisms of translational regulation in aging	5R01AG058713-05
2022	Molecular mechanisms of translational regulation in aging	5R01AG058713-04
2021	The role of iron homeostasis in aging	1R56AG066704-01A1
2021	Molecular mechanisms of translational regulation in aging	5R01AG058713-03
2020	Molecular mechanisms of translational regulation in aging	5R01AG058713-02
2019	Molecular mechanisms of translational regulation in aging	1R01AG058713-01A1
2018	Molecular mechanisms of translational regulation in aging	3R56AG054566-01A1S1	4
2017	Molecular mechanisms of translational regulation in aging	1R56AG054566-01A1	4
2016	Endoplasmic Reticulum Thiol Redox State and Unfolded Protein Response in Aging	5R00AG040191-05	9
2015	Endoplasmic Reticulum Thiol Redox State and Unfolded Protein Response in Aging	5R00AG040191-04	9

Showing 10 of 12 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Patnaik PK, Nady N, Barlit H, Gülhan A, Labunskyy VM. Lifespan regulation by targeting heme signaling in yeast. bioRxiv. 2024 Jan 21.View Related Profiles.

Patnaik, Praveen
Labunskyy, Vyacheslav

PMID: 38293148; PMCID: PMC10827197; DOI: 10.1101/2024.01.20.576446;

Patnaik PK, Barlit H, Labunskyy VM. Manipulating mRNA-binding protein Cth2 function in budding yeast Saccharomyces cerevisiae. STAR Protoc. 2024 Mar 15; 5(1):102807.View Related Profiles.

Patnaik, Praveen
Labunskyy, Vyacheslav

PMID: 38165801; PMCID: PMC10797207; DOI: 10.1016/j.xpro.2023.102807;

Patnaik PK, Beaupere C, Barlit H, Romero AM, Tsuchiya M, Muir M, Martínez-Pastor MT, Puig S, Kaeberlein M, Labunskyy VM. Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function. Cell Rep. 2022 Jul 19; 40(3):111113.View Related Profiles.

Patnaik, Praveen
Labunskyy, Vyacheslav

PMID: 35858543; PMCID: PMC9382658; DOI: 10.1016/j.celrep.2022.111113;

Barlit H, Rai MK, Shoushtari SI, Beaupere C, Labunskyy VM. Genome-Wide Analysis of Translation in Replicatively Aged Yeast. Methods Mol Biol. 2021; 2252:151-173.View Related Profiles.

Rai, Manish
Labunskyy, Vyacheslav

PMID: 33765274; PMCID: PMC8565997; DOI: 10.1007/978-1-0716-1150-0_6;

Beaupere C, Labunskyy VM. (Un)folding mechanisms of adaptation to ER stress: lessons from aneuploidy. Curr Genet. 2019 Apr; 65(2):467-471. PMID: 30511161; PMCID: PMC6421085; DOI: 10.1007/s00294-018-0914-9;

Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):9586-9591. PMID: 30185560; PMCID: PMC6156608; DOI: 10.1073/pnas.1804264115;

Beaupere C, Chen RB, Pelosi W, Labunskyy VM. Genome-wide Quantification of Translation in Budding Yeast by Ribosome Profiling. J Vis Exp. 2017 12 21; (130). PMID: 29286414; PMCID: PMC5755679; DOI: 10.3791/56820;

Lorusso JS, Sviderskiy OA, Labunskyy VM. Emerging Omics Approaches in Aging Research. Antioxid Redox Signal. 2018 10 01; 29(10):985-1002. PMID: 28874057; PMCID: PMC6104250; DOI: 10.1089/ars.2017.7163;

Beaupere C, Wasko BM, Lorusso J, Kennedy BK, Kaeberlein M, Labunskyy VM. CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. Cell Rep. 2017 Feb 21; 18(8):1884-1892. PMID: 28228255; PMCID: PMC5327506; DOI: 10.1016/j.celrep.2017.01.077;

Gao J, Barroso C, Zhang P, Kim HM, Li S, Labrador L, Lightfoot J, Gerashchenko MV, Labunskyy VM, Dong MQ, Martinez-Perez E, Colaiácovo MP. N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Genes Dev. 2016 Nov 01; 30(21):2404-2416. PMID: 27881602; PMCID: PMC5131780; DOI: 10.1101/gad.277350.116;

Showing 10 of 26 results. Show More

Labunskyy VM, Hatfield DL, Gladyshev VN. Selenoproteins: molecular pathways and physiological roles. Physiol Rev. 2014 Jul; 94(3):739-77. PMID: 24987004; PMCID: PMC4101630; DOI: 10.1152/physrev.00039.2013;

Labunskyy VM, Suzuki Y, Hanly TJ, Murao A, Roth FP, Gladyshev VN. The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast. G3 (Bethesda). 2014 Jul; 4(7):1183-91. PMID: 24776987; PMCID: PMC4455768; DOI: 10.1534/g3.114.010868;

Labunskyy VM, Gerashchenko MV, Delaney JR, Kaya A, Kennedy BK, Kaeberlein M, Gladyshev VN. Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. PLoS Genet. 2014 Jan; 10(1):e1004019. PMID: 24391512; PMCID: PMC3879150; DOI: 10.1371/journal.pgen.1004019;

Labunskyy VM, Gladyshev VN. Role of reactive oxygen species-mediated signaling in aging. Antioxid Redox Signal. 2013 Oct 20; 19(12):1362-72. PMID: 22901002; PMCID: PMC3791051; DOI: 10.1089/ars.2012.4891;

Kasaikina MV, Fomenko DE, Labunskyy VM, Lachke SA, Qiu W, Moncaster JA, Zhang J, Wojnarowicz MW, Natarajan SK, Malinouski M, Schweizer U, Tsuji PA, Carlson BA, Maas RL, Lou MF, Goldstein LE, Hatfield DL, Gladyshev VN. Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice. J Biol Chem. 2011 Sep 23; 286(38):33203-12.View Related Profiles.

Moncaster, Juliet
Goldstein, Lee
Wojnarowicz, Mark
Labunskyy, Vyacheslav

PMID: 21768092; PMCID: PMC3190948; DOI: 10.1074/jbc.M111.259218;

Labunskyy VM, Lee BC, Handy DE, Loscalzo J, Hatfield DL, Gladyshev VN. Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. Antioxid Redox Signal. 2011 Jun 15; 14(12):2327-36. PMID: 21194350; PMCID: PMC3096499; DOI: 10.1089/ars.2010.3526;

Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehár J, Roth FP. Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection. Nat Methods. 2011 Feb; 8(2):159-64. PMID: 21217751; PMCID: PMC3076670; DOI: 10.1038/nmeth.1550;

Shchedrina VA, Zhang Y, Labunskyy VM, Hatfield DL, Gladyshev VN. Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins. Antioxid Redox Signal. 2010 Apr 1; 12(7):839-49. PMID: 19747065; PMCID: PMC2864662; DOI: 10.1089/ars.2009.2865;

Sengupta A, Carlson BA, Labunskyy VM, Gladyshev VN, Hatfield DL. Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells. Biochem Cell Biol. 2009 Dec; 87(6):953-61. PMID: 19935881; PMCID: PMC3471091; DOI: 10.1139/o09-064;

Labunskyy VM, Yoo MH, Hatfield DL, Gladyshev VN. Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses. Biochemistry. 2009 Sep 8; 48(35):8458-65. PMID: 19650649; PMCID: PMC2778599; DOI: 10.1021/bi900717p;

Kehr S, Malinouski M, Finney L, Vogt S, Labunskyy VM, Kasaikina MV, Carlson BA, Zhou Y, Hatfield DL, Gladyshev VN. X-ray fluorescence microscopy reveals the role of selenium in spermatogenesis. J Mol Biol. 2009 Jun 26; 389(5):808-18. PMID: 19379757; PMCID: PMC2778597; DOI: 10.1016/j.jmb.2009.04.024;

Labunskyy VM, Hatfield DL, Gladyshev VN. The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. IUBMB Life. 2007 Jan; 59(1):1-5. PMID: 17365173

Novoselov SV, Calvisi DF, Labunskyy VM, Factor VM, Carlson BA, Fomenko DE, Moustafa ME, Hatfield DL, Gladyshev VN. Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice. Oncogene. 2005 Dec 1; 24(54):8003-11. PMID: 16170372

Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J Biol Chem. 2006 Feb 10; 281(6):3536-43. PMID: 16319061

Labunskyy VM, Ferguson AD, Fomenko DE, Chelliah Y, Hatfield DL, Gladyshev VN. A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase. J Biol Chem. 2005 Nov 11; 280(45):37839-45. PMID: 16129668

Shostak K, Labunskyy V, Dmitrenko V, Malisheva T, Shamayev M, Rozumenko V, Zozulya Y, Zehetner G, Kavsan V. HC gp-39 gene is upregulated in glioblastomas. Cancer Lett. 2003 Aug 20; 198(2):203-10. PMID: 12957359

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 26 publications over 14 distinct years, with a maximum of 3 publications in 2005 and 2009 and 2011 and 2014 and 2017