Valentina Perissi | Profiles RNS

Valentina Perissi, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, University of California, San Diego
BSc, University of Torino

Websites

	Perissi Lab
	Biochemistry Faculty
	LinkedIn
	Public Relations - BU Experts

ORCID : 0000-0002-3716-0003

Valentina Perissi holds a Laurea in Molecular Biology from the University of Torino (Italy) and a PhD in Molecular Pathology from UCSD. After postdoctoral training in Epigenetics, Endocrinology and Metabolism in Dr. Geoff Rosenfeld’s HHMI laboratory at UCSD, she established an independent research group at Boston University. This transition was supported by a K99-R00 career development award from NIDDK and a Peter Paul Career Development Professorship from Boston University.

The overarching theme in the Perissi Lab is dissecting the molecular mechanisms that control metabolic adaptation in response to nutrients availability, cell differentiation and oxidative stress.
Current projects focus on two main areas:
1) Mechanisms regulating mitochondria-nuclear communication and genomic regulation of the mitochondrial stress response
2) Role of non-proteolytic K63 ubiquitination in the regulation of metabolic reprogramming.
Ongoing studies investigate these topics in the context of obesity-associated inflammation/insulin resistance and breast cancer.

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Coordination of PAR and Ub signaling in mitochondria
04/01/2023 - 03/31/2028 (PI)
NIH/National Institute of General Medical Sciences
5R35GM149339-02

Regulation of mitochondrial homeostasis through retrograde signaling
04/01/2018 - 03/31/2023 (PI)
NIH/National Institute of General Medical Sciences
5R01GM127625-04

Coordinated regulation of breast cancer cell growth and metabolism though inhibition of non-proteolytic K63 ubiquitination
02/01/2017 - 01/31/2021 (PI)
Department of Defense

Ubiquitin-dependent Regulation of Inflammation and Insulin Resistance
04/15/2014 - 03/31/2019 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK100422-05

Expansion of the Diabetes Research Center's Pilot and Feasibility Program
09/14/2012 - 06/30/2016 (Co-Investigator of Sub-Project / SP)
Joslin Diabetes Center NIH NIDDK
5P30DK036836-29

Ubiquitin regulation in PPARgamma-mediated trascriptional regulation
04/01/2012 - 03/31/2014 (Subcontract PI)
Boston Medical Center Corporation NIH NIDDK
5P30DK046200-20

Role of the NCoR Corepressor Complex in the Development of Insulin Resistance
09/25/2010 - 06/30/2013 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R00DK078756-05

Boston Nutrition Obesity Research Center P&F Projects Targeting URM Early Career Scientists
06/01/2021 - 05/31/2024 (PI)
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
3P30DK046200-29S1

Boston Nutrition Obesity Research Center - Administrative Supplement
06/01/2019 - 05/31/2024 (PI)
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
3P30DK046200-27S1

Boston nutrition Obesity Research Center(CCRC/Epid/Tc)
06/01/2018 - 05/31/2024 (Multi-PI)
PI: Valentina Perissi, PhD
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS

Boston Nutrition Obesity Research Center (Pilot)
06/01/2018 - 05/31/2024 (Multi-PI)
PI: Valentina Perissi, PhD
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS

Boston Nutrition Obesity Research Center(Administrative Core
06/01/2018 - 05/31/2024 (Multi-PI)
PI: Valentina Perissi, PhD
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
3P30DK046200-29S1

Boston Nutrition Obesity Research Center - supplement
06/01/2019 - 05/31/2023 (Multi-PI)
PI: Valentina Perissi, PhD
National Institutes of Health/DHHS/NIH
3P30DK046200-29S1

Boston Nutrition Obesity Research Center(Ac)
06/01/2018 - 05/31/2019 (Multi-PI)
PI: Valentina Perissi, PhD
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Coordination of PAR and Ub signaling in mitochondria	5R35GM149339-02
2023	Coordination of PAR and Ub signaling in mitochondria	1R35GM149339-01
2021	Regulation of mitochondrial homeostasis through retrograde signaling	5R01GM127625-04	2
2021	Boston Nutrition Obesity Research Center	5P30DK046200-29	948
2021	Boston Nutrition Obesity Research Center	3P30DK046200-29S2	948
2021	Boston Nutrition Obesity Research Center P&F Projects Targeting URM Early Career Scientists	3P30DK046200-29S1	948
2020	Regulation of mitochondrial homeostasis through retrograde signaling	5R01GM127625-03	2
2019	Regulation of mitochondrial homeostasis through retrograde signaling	5R01GM127625-02	2
2018	Regulation of mitochondrial homeostasis through retrograde signaling	1R01GM127625-01	2
2018	Regulation of mitochondrial homeostasis through retrograde signaling	3R01GM127625-01S1	2

Showing 10 of 20 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Gao Y, Kwan J, Orofino J, Burrone G, Mitra S, Fan TY, English J, Hekman R, Emili A, Lyons SM, Cardamone MD, Perissi V. Inhibition of K63 ubiquitination by G-Protein pathway suppressor 2 (GPS2) regulates mitochondria-associated translation. Pharmacol Res. 2024 Sep; 207:107336.View Related Profiles.

Lyons, Shawn
Perissi, Valentina

PMID: 39094987

Mitro N, Verdeguer F, Perissi V. Editorial: Epigenetics and metabolism. Front Endocrinol (Lausanne). 2024; 15:1373368. PMID: 38405145; PMCID: PMC10884298; DOI: 10.3389/fendo.2024.1373368;

Sepulveda GP, Gushchanskaia ES, Mora-Martin A, Esse R, Nikorich I, Ceballos A, Kwan J, Blum BC, Dholiya P, Emili A, Perissi V, Cardamone MD, Grishok A. DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin. bioRxiv. 2024 Feb 07.View Related Profiles.

Grishok, Alla
Blum, Benjamin
Gushchanskaia, Ekaterina
Sepulveda, Gian
Perissi, Valentina

PMID: 38370658; PMCID: PMC10871221; DOI: 10.1101/2024.02.06.579191;

Oliveira AG, Oliveira LD, Cruz MV, Guimarães DSPSF, Lima TI, Santos-Fávero BC, Luchessi AD, Pauletti BA, Leme AP, Bajgelman MC, Afonso J, Regitano LCA, Carvalho HF, Carneiro EM, Kobarg J, Perissi V, Auwerx J, Silveira LR. Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. J Biol Chem. 2023 Jun; 299(6):104702. PMID: 37059182; PMCID: PMC10203745; DOI: 10.1016/j.jbc.2023.104702;

Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V, Seidman CE, Seidman J, Chin MT, Chen C, Emili A. Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling. Int J Mol Sci. 2023 Mar 01; 24(5).View Related Profiles.

Luptak, Ivan
Moore, Jarrod
Goel, Raghuveera
Perissi, Valentina
Lin, Weiwei

PMID: 36902152; PMCID: PMC10002553; DOI: 10.3390/ijms24054724;

English J, Orofino J, Cederquist CT, Paul I, Li H, Auwerx J, Emili A, Belkina A, Cardamone D, Perissi V. GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity. Mol Metab. 2023 Mar; 69:101682.View Related Profiles.

Belkina, Anna
Cederquist, Carly
Perissi, Valentina

PMID: 36731652; PMCID: PMC9922684; DOI: 10.1016/j.molmet.2023.101682;

Cardamone MD, Gao Y, Kwan J, Hayashi V, Sheeran M, Xu J, English J, Orofino J, Emili A, Perissi V. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. J Cell Biol. 2022 03 07; 221(3).View Related Profiles.

Emili, Andrew
Perissi, Valentina

PMID: 35157000; PMCID: PMC8932523; DOI: 10.1083/jcb.202101021;

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212.View Related Profiles. PMID: 33417854; PMCID: PMC7831449; DOI: 10.1016/j.molcel.2020.12.028;

Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Front Cell Dev Biol. 2020; 8:608044.View Related Profiles.

Emili, Andrew
Tilston-Lunel, Andrew
Blum, Benjamin
Cardamone, Maria
Chan, Stefanie
Monti, Stefano
Perissi, Valentina
Varelas, Xaralabos

PMID: 33490071; PMCID: PMC7817781; DOI: 10.3389/fcell.2020.608044;

Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9.View Related Profiles. PMID: 33259812; PMCID: PMC7674017; DOI: 10.1016/j.molcel.2020.11.028;

Showing 10 of 37 results. Show More

English J, Son JM, Cardamone MD, Lee C, Perissi V. Decoding the rosetta stone of mitonuclear communication. Pharmacol Res. 2020 11; 161:105161.View Related Profiles.

Cardamone, Maria
Perissi, Valentina

PMID: 32846213; PMCID: PMC7755734; DOI: 10.1016/j.phrs.2020.105161;

Jones JEC, Rabhi N, Orofino J, Gamini R, Perissi V, Vernochet C, Farmer SR. The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet. Sci Rep. 2020 02 11; 10(1):2380.View Related Profiles.

Jones, Jessica
Rabhi, Nabil
Farmer, Stephen
Perissi, Valentina

PMID: 32047213; PMCID: PMC7012923; DOI: 10.1038/s41598-020-59284-w;

Lima TI, Guimarães DSPSF, Oliveira AG, Araujo H, Sponton CHG, Souza-Pinto NC, Saito Â, Figueira ACM, Palameta S, Bajgelman MC, Calixto A, Pinto S, Mori MA, Orofino J, Perissi V, Mottis A, Auwerx J, Silveira LR. Opposing action of NCoR1 and PGC-1a in mitochondrial redox homeostasis. Free Radic Biol Med. 2019 11 01; 143:203-208. PMID: 31408725

Cardamone MD, Orofino J, Labadorf A, Perissi V. Chromatin Immunoprecipitation of Murine Brown Adipose Tissue. J Vis Exp. 2018 11 21; (141).View Related Profiles.

Labadorf, Adam
Cardamone, Maria
Perissi, Valentina

PMID: 30531713; PMCID: PMC6684207; DOI: 10.3791/58682;

Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel KA, Rocha MC, Reeve AK, Falkous G, Perissi V, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Ann Neurol. 2018 08; 84(2):289-301. PMID: 30014514; PMCID: PMC6141001; DOI: 10.1002/ana.25288;

Cardamone MD, Tanasa B, Cederquist CT, Huang J, Mahdaviani K, Li W, Rosenfeld MG, Liesa M, Perissi V. Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell. 2018 03 01; 69(5):757-772.e7.View Related Profiles.

Cederquist, Carly
Mahdaviani, Kiana
Cardamone, Maria
Perissi, Valentina

PMID: 29499132; PMCID: PMC6022402; DOI: 10.1016/j.molcel.2018.01.037;

Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 Jul; 18(7):1123-1138.View Related Profiles.

Corkey, Barbara
Benador, Ilan
Mahdaviani, Kiana
Trudeau, Kyle
Cardamone, Maria
Shirihai, Orian
Aprahamian, Tamar
Perissi, Valentina

PMID: 28539390; PMCID: PMC5887905; DOI: 10.15252/embr.201643827;

Lentucci C, Belkina AC, Cederquist CT, Chan M, Johnson HE, Prasad S, Lopacinski A, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD, Perissi V. Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. J Biol Chem. 2017 Feb 17; 292(7):2754-2772.View Related Profiles.

Belkina, Anna
Nikolajczyk, Barbara
Cederquist, Carly
Snyder-Cappione , Jennifer
Cardamone, Maria
Monti, Stefano
Perissi, Valentina

PMID: 28039360; PMCID: PMC5314172; DOI: 10.1074/jbc.M116.755132;

Cederquist CT, Lentucci C, Martinez-Calejman C, Hayashi V, Orofino J, Guertin D, Fried SK, Lee MJ, Cardamone MD, Perissi V. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017 01; 6(1):125-137.View Related Profiles.

Cederquist, Carly
Cardamone, Maria
Fried, Susan
Perissi, Valentina

PMID: 28123943; PMCID: PMC5220281; DOI: 10.1016/j.molmet.2016.10.007;

Huang J, Cardamone MD, Johnson HE, Neault M, Chan M, Floyd ZE, Mallette FA, Perissi V. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. J Biol Chem. 2015 Jul 31; 290(31):19044-54.View Related Profiles.

Cardamone, Maria
Perissi, Valentina

PMID: 26070566; PMCID: PMC4521029; DOI: 10.1074/jbc.M115.637660;

Cardamone MD, Tanasa B, Chan M, Cederquist CT, Andricovich J, Rosenfeld MG, Perissi V. GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPAR?. Cell Rep. 2014 Jul 10; 8(1):163-76.View Related Profiles.

Cederquist, Carly
Cardamone, Maria
Perissi, Valentina

PMID: 24953653; PMCID: PMC4104678; DOI: 10.1016/j.celrep.2014.05.041;

Scafoglio C, Smolka M, Zhou H, Perissi V, Rosenfeld MG. The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation. PLoS One. 2013; 8(5):e59986. PMID: 23690919; PMCID: PMC3656868; DOI: 10.1371/journal.pone.0059986;

Cardamone MD, Krones A, Tanasa B, Taylor H, Ricci L, Ohgi KA, Glass CK, Rosenfeld MG, Perissi V. A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. Mol Cell. 2012 Apr 13; 46(1):91-104.View Related Profiles.

Cardamone, Maria
Perissi, Valentina

PMID: 22424771; PMCID: PMC3327812; DOI: 10.1016/j.molcel.2012.01.025;

Perissi V, Jepsen K, Glass CK, Rosenfeld MG. Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet. 2010 Feb; 11(2):109-23. PMID: 20084085; DOI: 10.1038/nrg2736;

Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell. 2009 Jul 10; 35(1):48-57. PMID: 19595715; PMCID: PMC2759189; DOI: 10.1016/j.molcel.2009.05.023;

Perissi V, Scafoglio C, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG. TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Mol Cell. 2008 Mar 28; 29(6):755-66. PMID: 18374649; PMCID: PMC2364611; DOI: 10.1016/j.molcel.2008.01.020;

Pascual G, Sullivan AL, Ogawa S, Gamliel A, Perissi V, Rosenfeld MG, Glass CK. Anti-inflammatory and antidiabetic roles of PPARgamma. Novartis Found Symp. 2007; 286:183-96; discussion 196-203. PMID: 18269183

Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, Glass CK, Rosenfeld MG. A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science. 2006 Jun 23; 312(5781):1798-802. PMID: 16794079

Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, Perissi V, Rose DW, Willson TM, Rosenfeld MG, Glass CK. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature. 2005 Sep 29; 437(7059):759-63. PMID: 16127449; PMCID: PMC1464798; DOI: 10.1038/nature03988;

Perissi V, Rosenfeld MG. Controlling nuclear receptors: the circular logic of cofactor cycles. Nat Rev Mol Cell Biol. 2005 Jul; 6(7):542-54. PMID: 15957004

Ogawa S, Lozach J, Jepsen K, Sawka-Verhelle D, Perissi V, Sasik R, Rose DW, Johnson RS, Rosenfeld MG, Glass CK. A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc Natl Acad Sci U S A. 2004 Oct 5; 101(40):14461-6. PMID: 15452344; PMCID: PMC521940

Perissi V, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell. 2004 Feb 20; 116(4):511-26. PMID: 14980219

Li X, Perissi V, Liu F, Rose DW, Rosenfeld MG. Tissue-specific regulation of retinal and pituitary precursor cell proliferation. Science. 2002 Aug 16; 297(5584):1180-3. PMID: 12130660

Wen YD, Perissi V, Staszewski LM, Yang WM, Krones A, Glass CK, Rosenfeld MG, Seto E. The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7202-7. PMID: 10860984; PMCID: PMC16523

Perissi V, Menini N, Cottone E, Capello D, Sacco M, Montaldo F, De Bortoli M. AP-2 transcription factors in the regulation of ERBB2 gene transcription by oestrogen. Oncogene. 2000 Jan 13; 19(2):280-8. PMID: 10645007

Perissi V, Staszewski LM, McInerney EM, Kurokawa R, Krones A, Rose DW, Lambert MH, Milburn MV, Glass CK, Rosenfeld MG. Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev. 1999 Dec 15; 13(24):3198-208. PMID: 10617569; PMCID: PMC317209

Perissi V, Dasen JS, Kurokawa R, Wang Z, Korzus E, Rose DW, Glass CK, Rosenfeld MG. Factor-specific modulation of CREB-binding protein acetyltransferase activity. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3652-7. PMID: 10097092; PMCID: PMC22349

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 37 publications over 23 distinct years, with a maximum of 3 publications in 2018 and 2020 and 2023 and 2024