Stefano Monti, PhD Hear my name
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Computational Biomedicine

PhD, University of Pittsburgh
MS, University of Pittsburgh
MS, University of Houston
BS, Università degli Studi di Udine

Pronouns: he/him/his



Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.

Dr. Monti's laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.

Associate Professor
Boston University School of Public Health
Biostatistics


Member
Boston University
BU-BMC Cancer Center


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Bioinformatics Graduate Program


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Defining the Beta-catenin/CBP axis in head and neck cancer
12/07/2020 - 11/30/2025 (Multi-PI)
PI: Stefano Monti, PhD
NIH/National Institute of Dental & Craniofacial Research
5R01DE030350-03

Multiscale analysis of metabolic inflammation as a driver of breast cancer
09/09/2020 - 08/31/2025 (Multi-PI)
PI: Stefano Monti, PhD
NIH/National Cancer Institute
5U01CA243004-04

System-Level Analyses of Multi-Omics Data to Reveal Mechanisms of Head & Neck Cancer
03/17/2022 - 01/31/2025 (PI)
NIH/National Institute of Dental & Craniofacial Research
5R01DE031831-02

Intercepting head and neck cancer using functional genomics approaches
09/01/2020 - 08/31/2022 (Key Person / Mentor)
NIH/National Institute of Dental & Craniofacial Research
5F31DE029701-02

Metabolic Pathways of Increased Cardiovascular risk in type 2 Diabetes
04/01/2016 - 02/29/2020 (Subcontract PI)
Joslin Diabetes Center NIH NHLBI
5R01HL132254-04

Novel genomic models to predict breast carcinogenicity of environmental chemicals
10/01/2014 - 09/30/2016 (PI)
Art beCAUSE


Lymphoma Target Testing Center
07/01/2013 - 06/30/2016 (Subcontract PI)
Dana-Farber Cancer Institute Paul E. Singer Fdn


Receptor-based Developmental and Reproductive Toxicity of Superfund Chemicals
09/20/2012 - 03/31/2016 (Co-Investigator)
PI: David H. Sherr, PhD
NIH/National Institute of Environmental Health Sciences
5P42ES007381-19

Targeting Genetically-driven p53 and Cell Cycle Deregulation in DLBCL
10/01/2012 - 09/30/2015 (Subcontract PI)
Dana-Farber Cancer Institute Leukemia & Lymph Soc




Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Don J, Schork AJ, Glusman G, Rappaport N, Cummings SR, Duggan D, Raju A, Hellberg KG, Gunn S, Monti S, Perls T, Lapidus J, Goetz LH, Sebastiani P, Schork NJ. The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank. Geroscience. 2024 Mar 07.View Related Profiles. PMID: 38451433
     
  2. Li M, Song Z, Gurinovich A, Schork N, Sebastiani P, Monti S. yQTL Pipeline: a structured computational workflow for large scale quantitative trait loci discovery and downstream visualization. bioRxiv. 2024 Jan 30.View Related Profiles. PMID: 38370654; PMCID: PMC10874520; DOI: 10.1101/2024.01.26.577518;
     
  3. Leshchyk A, Xiang Q, Andersen SL, Gurinovich A, Song Z, Lee JH, Christensen K, Yashin A, Wojczynski M, Schwander K, Perls TT, Monti S, Sebastiani P. Mosaic Chromosomal Alterations and Human Longevity. J Gerontol A Biol Sci Med Sci. 2023 Aug 27; 78(9):1561-1568.View Related Profiles. PMID: 36988570; PMCID: PMC10460554; DOI: 10.1093/gerona/glad095;
     
  4. Khan MM, Frustino J, Villa A, Nguyen BC, Woo SB, Johnson WE, Varelas X, Kukuruzinska M, Monti S. Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer. Hum Genomics. 2023 Aug 04; 17(1):72.View Related Profiles. PMID: 37542347; PMCID: PMC10403884; DOI: 10.1186/s40246-023-00519-y;
     
  5. Reed ER, Jankowski SA, Spinella AJ, Noonan V, Haddad R, Nomoto K, Matsui J, Bais MV, Varelas X, Kukuruzinska MA, Monti S. ß-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer. Transl Res. 2023 Oct; 260:46-60.View Related Profiles. PMID: 37353110; PMCID: PMC10527608; DOI: 10.1016/j.trsl.2023.05.007;
     
  6. Karagiannis TT, Monti S, Sebastiani P. Bayesian differential analysis of cell type proportions: opinion. Front Genet. 2023; 14:1205499.View Related Profiles. PMID: 37323674; PMCID: PMC10267376; DOI: 10.3389/fgene.2023.1205499;
     
  7. Federico A, Kern J, Varelas X, Monti S. Structure learning for gene regulatory networks. PLoS Comput Biol. 2023 May; 19(5):e1011118.View Related Profiles. PMID: 37200395; PMCID: PMC10231840; DOI: 10.1371/journal.pcbi.1011118;
     
  8. Karagiannis TT, Dowrey TW, Villacorta-Martin C, Montano M, Reed E, Belkina AC, Andersen SL, Perls TT, Monti S, Murphy GJ, Sebastiani P. Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity. EBioMedicine. 2023 Apr; 90:104514.View Related Profiles. PMID: 37005201; PMCID: PMC10114155; DOI: 10.1016/j.ebiom.2023.104514;
     
  9. Leshchyk A, Xiang Q, Andersen SL, Gurinovich A, Song Z, Lee JH, Christensen K, Yashin A, Wojczynski M, Schwander K, Perls TT, Monti S, Sebastiani P. Mosaic chromosomal alterations and human longevity. J Gerontol A Biol Sci Med Sci. 2023 Mar 29.View Related Profiles. PMID: 36988570; PMCID: PMC10460554; DOI: 10.1093/gerona/glad095;
     
  10. Khan MM, Frustino J, Villa A, Nguyen BC, Woo SB, Johnson WE, Varelas X, Kukuruzinska M, Monti S. Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer. bioRxiv. 2023 Mar 24.View Related Profiles. PMID: 36993637; PMCID: PMC10055367; DOI: 10.1101/2023.03.24.534064;
     
Showing 10 of 135 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 130 publications over 30 distinct years, with a maximum of 11 publications in 2021

YearPublications
19951
19961
19972
19982
19992
20001
20011
20021
20032
20042
20052
20067
20076
20083
20091
20102
20115
20124
20137
20146
20156
201610
20177
20187
20198
20207
202111
20226
20238
20242


Study: Strong immune cells may be the key to living to 100

Atlanta Journal Constitution 4/18/2023

Immune System May Hold Secret to Living to 100

HealthDay 4/6/2023

New Study Finds The Key To Living To 100 And Beyond

iHeart 4/5/2023

Secret To Longevity? Scientists Find Unique Immune Cells In Centenarians That Protect From Illnesses

Medical Daily 4/5/2023

‘Elite’ Immune Systems Could Be Centenarians’ Secret: Study

WebMD 4/5/2023

DNA study reveals one key factor that helps some people live beyond 100

Yahoo News 4/4/2023

This is what you need to live to 100: DNA study

New York Post 4/4/2023

A 'blueprint' for longevity: New study has an answer for why some people live to be over 100

USA Today 4/3/2023

Chemicals in Your Furniture Might Impact Your Metabolism

Technology Networks 8/10/2021

Computational Model Identifies New Candidate Cancer Genes

Drug Target Review 11/18/2019

Foundation focused on causes of breast cancer

The Daily News 5/15/2018

Available to Mentor as: (Review Mentor Role Definitions):
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  • Research / Scholarly Mentor
Contact for Mentoring:

75 E. Newton St Evans Building
Boston MA 02118
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