Joseph P. Mizgerd, ScD Hear my name
Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

ScD, Harvard School of Public Health
BA, Amherst College

Pronouns: he/him/his



Our work focuses on immunology in the lung and its influence on acute lower respiratory tract infections. Our research is illuminating the regulation and function of innate and adaptive immune cells and signals in the lung, and how variations in these parameters determine pneumonia susceptibility and outcome. Lung defense consists of immune resistance (the ability to eliminate microbes) and tissue resilience (the ability to prevent or withstand injurious stimuli from infection and inflammation). Both activities are accomplished by the coordinated activities of diverse cell types within the lung, involving some that are constitutively present (including diverse types of epithelial cells, macrophages, lymphocytes, and more) as well as others newly recruited to the infected tissue (including neutrophils plus additional myeloid or lymphoid cells). Effective and productive communication amongst these cells can efficiently destroy microbes without damaging the lung, maintaining respiratory health. Dysregulation of these pathways instead promotes infection (e.g., pneumonia), injury (e.g., the acute respiratory distress syndrome), and other pulmonary diseases. Elucidating factors that differentiate lung infection resistance and susceptibility will enable new approaches to preventing and treating pneumonia.

Director
Boston University Chobanian & Avedisian School of Medicine
Pulmonary Center


Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology


Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Fibrin in the Infected Lung
02/15/2024 - 01/31/2028 (PI)
NIH/National Heart, Lung, and Blood Institute
1R01HL171499-01

LOX-1 as a protective countermeasure in response to lung infection
06/15/2023 - 05/31/2027 (Subcontract PI)
University of Massachusetts, Medical School NIH NHLBI
5R01HL165718-02

Pulmonary pathophysiology sub-phenotypes of pneumonia
02/01/2022 - 01/31/2027 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI162850-03

Biology of the Lung: A Multidisciplinary Program
07/01/2021 - 06/30/2026 (Multi-PI)
PI: Joseph P. Mizgerd, ScD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-48

Sub-phenotyping pneumonia by lung pathobiology
09/01/2023 - 06/30/2025 (Key Person / Mentor)
PI: Bradley E. Hiller, Ph.D.
NIH/National Heart, Lung, and Blood Institute
5F32HL170650-02

Lung-resident antibacterial heterotypic immunity
07/01/2019 - 06/30/2025 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI115053-09

Protective lung memory B cell functions and dynamics during respiratory infection
06/01/2021 - 05/31/2025 (Key Person / Mentor)
PI: Neelou Etesami
NIH/National Heart, Lung, and Blood Institute
5F30HL158109-04

Pneumonia Biology
01/11/2017 - 12/31/2024 (PI)
NIH/National Heart, Lung, and Blood Institute
5R35HL135756-07

PASC Pathobiology: long-term remodeling after acute infection
03/01/2022 - 02/29/2024 (Subcontract PI)
President & Fellows of Harvard College on behalf of Harvard Medical School China Evergrande Gr


The B cell repertoire as a window into the nature and impact of the lung virome
05/01/2019 - 04/30/2023 (Multi-PI)
PI: Joseph P. Mizgerd, ScD
NIH/National Heart, Lung, and Blood Institute
5R33HL137081-05

Showing 10 of 26 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2025 Fibrin in the Infected Lung 5R01HL171499-02
2025 Pulmonary pathophysiology sub-phenotypes of pneumonia 5R01AI162850-04
2024 Fibrin in the Infected Lung 1R01HL171499-01
2024 Pulmonary pathophysiology sub-phenotypes of pneumonia 5R01AI162850-03
2024 Biology of the Lung: A Multidisciplinary Program 5T32HL007035-49
2023 Pulmonary pathophysiology sub-phenotypes of pneumonia 5R01AI162850-02
2023 Pneumonia Biology 5R35HL135756-07
2023 Lung-resident antibacterial heterotypic immunity 5R01AI115053-09
2023 Biology of the Lung: A Multidisciplinary Program 5T32HL007035-48
2022 Pulmonary pathophysiology sub-phenotypes of pneumonia 1R01AI162850-01A1
Showing 10 of 67 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Traber KE, Mizgerd JP. The Integrated Pulmonary Immune Response to Pneumonia. Annu Rev Immunol. 2025 Mar 04. PMID: 40036700; DOI: 10.1146/annurev-immunol-082323-031642;
     
  2. Soucy AM, Brune JE, Jayaraman A, Shenoy AT, Korkmaz FT, Etesami NS, Hiller BE, Martin IM, Goltry WN, Ha CT, Crossland NA, Campbell JD, Beach TG, Traber KE, Jones MR, Quinton LJ, Bosmann M, Frevert CW, Mizgerd JP. Transcriptomic responses of lung mesenchymal cells during pneumonia. JCI Insight. 2025 Feb 25.View Related Profiles. PMID: 39998887
     
  3. Ravi VR, Korkmaz FT, De Ana CL, Lu L, Shao FZ, Odom CV, Barker KA, Ramanujan A, Niszczak EN, Goltry WN, Martin IMC, Ha CT, Quinton LJ, Jones MR, Fine A, Welch JD, Chen F, Belkina AC, Mizgerd JP, Shenoy AT. Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate onset of allergic airway neutrophilic disease. Cell Rep. 2025 Feb 11; 115294.View Related Profiles. PMID: 39965565
     
  4. Harlow OS, Ravi VR, Ke F, Sanders NL, Armstrong E, Mizgerd JP, Shenoy AT. The mysterious case of missing lymphocytes: a cautionary tale of interinstitutional variability in outcomes of lung dissociation protocols. Am J Physiol Lung Cell Mol Physiol. 2025 Feb 01; 328(2):L260-L266. PMID: 39786964
     
  5. Yin J, Hayes KM, Ong MS, Mizgerd JP, Cunningham-Rundles C, Dominguez I, Barmettler S, Farmer JR, Maglione PJ. Common Variable Immunodeficiency Clinical Manifestations Are Shaped by Presence and Type of Heterozygous NFKB1 Variants. J Allergy Clin Immunol Pract. 2025 Mar; 13(3):639-646.View Related Profiles. PMID: 39672378; PMCID: PMC11885011; DOI: 10.1016/j.jaip.2024.12.002;
     
  6. Deshmukh H, Whitsett J, Zacharias W, Way SS, Martinez FD, Mizgerd J, Pryhuber G, Ambalavanan N, Bacharier L, Natarajan A, Tamburro R, Lin S, Randolph A, Nino G, Mejias A, Ramilo O. Impact of Viral Lower Respiratory Tract Infection (LRTI) in Early Childhood (0-2 Years) on Lung Growth and Development and Lifelong Trajectories of Pulmonary Health: A National Institutes of Health (NIH) Workshop Summary. Pediatr Pulmonol. 2025 Jan; 60(1):e27357. PMID: 39565217; PMCID: PMC11740654; DOI: 10.1002/ppul.27357;
     
  7. Hiller BE, Mizgerd JP. IFN-? and YAP lead epithelial cells astray after severe respiratory infection. J Clin Invest. 2024 Oct 01; 134(19).View Related Profiles. PMID: 39352386; PMCID: PMC11444161; DOI: 10.1172/JCI185072;
     
  8. Auld SC, Sheshadri A, Alexander-Brett J, Aschner Y, Barczak AK, Basil MC, Cohen KA, Dela Cruz C, McGroder C, Restrepo MI, Ridge KM, Schnapp LM, Traber K, Wunderink RG, Zhang D, Ziady A, Attia EF, Carter J, Chalmers JD, Crothers K, Feldman C, Jones BE, Kaminski N, Keane J, Lewinsohn D, Metersky M, Mizgerd JP, Morris A, Ramirez J, Samarasinghe AE, Staitieh BS, Stek C, Sun J, Evans SE. Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2024 Sep; 21(9):1219-1237.View Related Profiles. PMID: 39051991
     
  9. Lee MM, Zuo Y, Steiling K, Mizgerd JP, Kalesan B, Walkey AJ. Clinical risk factors and blood protein biomarkers of 10-year pneumonia risk. PLoS One. 2024; 19(7):e0296139.View Related Profiles. PMID: 38968193; PMCID: PMC11226120; DOI: 10.1371/journal.pone.0296139;
     
  10. Ysasi AB, Engler AE, Bawa PS, Wang F, Conrad RD, Yeung AK, Rock JR, Beane-Ebel J, Mazzilli SA, Franklin RA, Mizgerd JP, Murphy GJ. A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism. iScience. 2024 Jul 19; 27(7):110169.View Related Profiles. PMID: 38993668; PMCID: PMC11238131; DOI: 10.1016/j.isci.2024.110169;
     
Showing 10 of 152 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 152 publications over 31 distinct years, with a maximum of 14 publications in 2012

YearPublications
19952
19962
19971
19983
19994
20001
20014
20024
20032
20044
20053
20064
20075
20084
20098
20105
201110
201214
20134
20145
20154
20162
201711
20184
20193
20205
202111
20227
20235
20247
20254

2023 American Thoracic Society: Recognition Award for Scientific Accomplishment
2021 BU: Jerome S. Brody, MD, Professor of Pulmonary Medicine
2021 American Thoracic Society: Scientific Accomplishment Award for Allergy, Immunology & Inflammation
2020 BU: University Lecture
2018 American Thoracic Society: ATS Fellow
2017 NIH: NHLBI Outstanding Investigator
2017 BUSM Department of Medicine: Robert Dawson Evans Research Mentoring Award
1999 Francis Families Foundation: Parker B. Francis Fellow in Pulmonary Research
1998 American Lung Association: Edward Livingston Trudeau Scholar

Available to Mentor as: (Review Mentor Role Definitions):
  • Co-Mentor or Peer Mentor
  • Diversity Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')

72 E. Concord St Housman (R)
Boston MA 02118
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