Our work focuses on immunology in the lung and its influence on acute lower respiratory tract infections. Our research is illuminating the regulation and function of innate and adaptive immune cells and signals in the lung, and how variations in these parameters determine pneumonia susceptibility and outcome. Lung defense consists of immune resistance (the ability to eliminate microbes) and tissue resilience (the ability to prevent or withstand injurious stimuli from infection and inflammation). Both activities are accomplished by the coordinated activities of diverse cell types within the lung, involving some that are constitutively present (including diverse types of epithelial cells, macrophages, lymphocytes, and more) as well as others newly recruited to the infected tissue (including neutrophils plus additional myeloid or lymphoid cells). Effective and productive communication amongst these cells can efficiently destroy microbes without damaging the lung, maintaining respiratory health. Dysregulation of these pathways instead promotes infection (e.g., pneumonia), injury (e.g., the acute respiratory distress syndrome), and other pulmonary diseases. Elucidating factors that differentiate lung infection resistance and susceptibility will enable new approaches to preventing and treating pneumonia.
Diversity, Equity, Inclusion and Accessibility
I care deeply about diversity as the Pulmonary Center Director, as Principal Investigator of a research team, and as a person who believes this involves fundamental human rights. Diversity strengthens groups, making them more creative, more open, more supportive, more positive, more joyous, more insightful, more productive, and more sustaining. Forces that oppose or constrain diversity are toxic and need to be countered. I actively work to build diversity in our teams. I encourage suggestions for how we can do so better. Fostering diversity requires equity, inclusion, and accessibility. Principles of DEIA are driving factors for us as we build teams and work together in the Center and the laboratory.
The Pulmonary Center includes researchers, clinicians, educators, and administrators who are dedicated to the principles of DEIA. Our Center houses multiple enterprises created specifically to improve diversity. Our Racial Equity Committee includes faculty, trainees, and staff who meet regularly to envision and enact ways we can improve DEIA in the Pulmonary Center. As part of this persistent effort for improvement, this committee provides a monthly racial equity educational program for everyone in the Center, involving readings, seminars, and interactive workshops. All in the Center participate. The Pulmonary Center’s Social Justice Forum was created by our trainees, beginning as a series of meetings to discuss among themselves injustices and how to overcome them and which evolved into a visiting speaker series inviting scientists from under-represented groups to share what they recognize as obstacles faced, individual strategies for success, and institutional opportunities for improvement. The Pulmonary Center houses a Faculty Recruitment Diversity Committee, and all faculty searches coordinate activities with this standing committee in order to ensure that the principles of DEIA consistently and effectively guide and inform the processes and outcomes of our recruitment efforts. The Center houses a T32 training program that trains predoctoral and postdoctoral PhD, MD, and MD/PhD researchers and has been funded by the NIH for 50 years; a critical component of this program is its major emphasis and concerted attention on increasing diversity in its trainee pool. A contributing factor in the long-term success of this program is its commitment to training diverse groups of students and fellows to strengthen the scientific work-force.
As PI, I lead a research team that is dynamic by design, with members changing regularly, but this research team is always inclusive and diverse in multiple ways. Current and former members have self-identified as black, brown, LatinX, Asian, white, mixed, or other. Trainees have included recent immigrants as well as citizens of Canada, France, India, Ireland, Japan, Jordan, South Korea, Togo, or Venezuela. Half of all current and former doctoral students and postdoctoral fellows mentored have been female, and a third have been persons of color. Many of our current and former team are members of the LGBTQIA+ community. The first deaf student to receive a PhD from the BU School of Medicine, to our knowledge, was from our lab group and broke a barrier in diversity that others now follow. We modify our research team schedules, spaces, and activities to bolster accessibility for varying needs, for example to accommodate disabilities or religious practices. Team members bring highly varied life experiences and perspectives, including those who are deeply religious (and from different faiths) or atheist, who are from disadvantaged or wealthier backgrounds, who are single or with intense family demands, who tilt liberal or conservative, and more. The group always includes members from different training stages (e.g., at any one time there may be high school students, college students, Master’s students, MD students, PhD and MD/PhD students, PhD and MD/PhD postdocs, MD clinical fellows, junior faculty, and/or visiting faculty), which provides an enriching mixture of ages and experiences. We are active in institutional initiatives designed to foster diversity in science, such as BUSM’s Summer Training for Research Scholars (STaRS) Program. All of our lab team value and celebrate diversity. While grateful for the diversity our research teams have accomplished through the present, we are far from satisfied and strive to continue improving diversity in our current and coming teams and in tomorrow’s scientific research community.
Director
Boston University Chobanian & Avedisian School of Medicine
Pulmonary Center
Professor
Boston University Chobanian & Avedisian School of Medicine
Biochemistry & Cell Biology
Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology
Member
Boston University
Evans Center for Interdisciplinary Biomedical Research
Member
Boston University
Genome Science Institute
Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
This tab shows grant data from BMC Sponsored Research. It includes:
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- Data is sorted by project end date, and updated monthly.
This tab shows grant data from BU Sponsored Research. It includes:
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- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
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from BU or BMC sources.
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from the Boston VA. We are only showing grant title, and only for people in the role of PI.
Fibrin in the Infected Lung02/15/2024 - 01/31/2028 (PI)
NIH/National Heart, Lung, and Blood Institute1R01HL171499-01
LOX-1 as a protective countermeasure in response to lung infection06/15/2023 - 05/31/2027 (Subcontract PI)
University of Massachusetts, Medical School NIH NHLBI1R01HL165718-01A1
Pulmonary pathophysiology sub-phenotypes of pneumonia02/01/2022 - 01/31/2027 (PI)
NIH/National Institute of Allergy & Infectious Diseases5R01AI162850-03
Biology of the Lung: A Multidisciplinary Program07/01/2021 - 06/30/2026 (Multi-PI)
PI:
Joseph P. Mizgerd, ScDNIH/National Heart, Lung, and Blood Institute5T32HL007035-48
Sub-phenotyping pneumonia by lung pathobiology09/01/2023 - 08/31/2025 (Key Person / Mentor)
PI:
Bradley E. Hiller, Ph.D.NIH/National Heart, Lung, and Blood Institute1F32HL170650-01
Lung-resident antibacterial heterotypic immunity07/01/2019 - 06/30/2025 (PI)
NIH/National Institute of Allergy & Infectious Diseases5R01AI115053-09
Protective lung memory B cell functions and dynamics during respiratory infection06/01/2021 - 05/31/2025 (Key Person / Mentor)
PI:
Neelou EtesamiNIH/National Heart, Lung, and Blood Institute5F30HL158109-04
Pneumonia Biology01/11/2017 - 12/31/2024 (PI)
NIH/National Heart, Lung, and Blood Institute5R35HL135756-07
PASC Pathobiology: long-term remodeling after acute infection03/01/2022 - 02/29/2024 (Subcontract PI)
President & Fellows of Harvard College on behalf of Harvard Medical School China Evergrande Gr
The B cell repertoire as a window into the nature and impact of the lung virome05/01/2019 - 04/30/2023 (Multi-PI)
PI:
Joseph P. Mizgerd, ScDNIH/National Heart, Lung, and Blood Institute5R33HL137081-05
Showing 10 of 26 results.
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Lung epithelial cell reprogramming by CD4 T cells01/01/2022 - 03/31/2023 (Key Person / Mentor)
PI:
Anukul Shenoy, PhDNIH/National Heart, Lung, and Blood Institute5K99HL157555-02
Pneumonia Biology08/15/2020 - 07/31/2021 (PI)
NIH/National Heart, Lung, and Blood Institute3R35HL135756-04S1
Biology of the Lung: A Multidisciplinary Program07/01/2018 - 06/30/2021 (Multi-PI)
PI:
Joseph P. Mizgerd, ScDNIH/National Heart, Lung, and Blood Institute5T32HL007035-45
Biology of the Lung: A Multidisciplinary Program07/01/2017 - 06/30/2021 (Multi-PI)
PI:
Joseph P. Mizgerd, ScDNIH/National Heart, Lung, and Blood Institute5T32HL007035-42
Biology of the Lung: A Multidisciplinary Program07/01/2016 - 06/30/2021 (Multi-PI)
PI:
Joseph P. Mizgerd, ScDNIH/National Heart, Lung, and Blood Institute5T32HL007035-42
Noninvasive Quantification of Pulmonary Fibrosis Due to Radiation Induced Lung Injury Using [68Ga]CBP8 Type l Collagen Probe-10/01/2019 - 07/28/2020 (PI)
The CHEST Foundation
Lung-resident antibacterial heterotypic immunity07/01/2015 - 06/30/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases5R01AI115053-04
The B cell repertoire as a window into the nature and impact of the lung virome05/01/2017 - 04/30/2019 (Multi-PI)
PI:
Joseph P. Mizgerd, ScDNIH/National Heart, Lung, and Blood Institute5R61HL137081-02
Macrophage protection in pneumococcal pneumonia08/20/2016 - 07/31/2018 (PI)
NIH/National Institute of Allergy & Infectious Diseases1R56AI122763-01A1
Biology of the Lung: A Multidisciplinary Program07/01/2011 - 06/30/2017 (Multi-PI)
PI:
Joseph P. Mizgerd, ScDNIH/National Heart, Lung, and Blood Institute5T32HL007035-40
NF-kB Innate Immunity in the Lungs08/01/2016 - 12/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute4R01HL068153-13
Cytokine-stimulated systemic defenses during pneumococcal pneumonia12/01/2004 - 12/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL079392-10
Vectored Delivery of Oligoclonal Antibodies for Protection Against Enterotoxin Mediated Diarrheal Diseases02/01/2016 - 11/30/2016 (Subcontract PI)
University of Massachusetts, Worcester DOD ARO
NF-kB Innate Immunity in the Lungs08/05/2013 - 07/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute5R01HL068153-12
Influence of Macrophage NF-kB Activation on the Outcome of Pneumococcal Pneumonia08/01/2012 - 07/31/2015 (Key Person / Mentor)
PI:
Fadie Thomas ColemanNIH/National Heart, Lung, and Blood Institute5F31HL114360-03
NK-kB Re1A in lung epithelial cells and in neutrophils during pneumonia07/01/2011 - 06/30/2013 (Key Person)
PI:
Kazuko Yamamoto, MD, PhDAmerican Lung Association
Showing 10 of 65 results.
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Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
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Auld SC, Sheshadri A, Alexander-Brett J, Aschner Y, Barczak AK, Basil MC, Cohen KA, Dela Cruz C, McGroder C, Restrepo MI, Ridge KM, Schnapp LM, Traber K, Wunderink RG, Zhang D, Ziady A, Attia EF, Carter J, Chalmers JD, Crothers K, Feldman C, Jones BE, Kaminski N, Keane J, Lewinsohn D, Metersky M, Mizgerd JP, Morris A, Ramirez J, Samarasinghe AE, Staitieh BS, Stek C, Sun J, Evans SE. Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2024 Sep; 21(9):1219-1237.View Related Profiles. PMID: 39051991
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Ysasi AB, Engler AE, Bawa PS, Wang F, Conrad RD, Yeung AK, Rock JR, Beane-Ebel J, Mazzilli SA, Franklin RA, Mizgerd JP, Murphy GJ. A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism. iScience. 2024 Jul 19; 27(7):110169.View Related Profiles. PMID: 38993668; PMCID: PMC11238131; DOI: 10.1016/j.isci.2024.110169;
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Etesami NS, Barker KA, Shenoy AT, De Ana CL, Arafa EI, Grifno GN, Matschulat AM, Vannini ME, Pihl RMF, Breen MP, Soucy AM, Goltry WN, Ha CT, Betsuyaku H, Browning JL, Varelas X, Traber KE, Jones MR, Quinton LJ, Maglione PJ, Nia HT, Belkina AC, Mizgerd JP. B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells. Front Immunol. 2024; 15:1382638.View Related Profiles. PMID: 38715601; PMCID: PMC11074383; DOI: 10.3389/fimmu.2024.1382638;
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Lyon De Ana C, Shenoy AT, Barker KA, Arafa EI, Etesami NS, Korkmaz FT, Soucy AM, Breen MP, Martin IMC, Tilton BR, Devarajan P, Crossland NA, Pihl RMF, Goltry WN, Belkina AC, Jones MR, Quinton LJ, Mizgerd JP. GL7 ligand expression defines a novel subset of CD4+ TRM cells in lungs recovered from pneumococcus. Mucosal Immunol. 2023 Oct; 16(5):699-710.View Related Profiles. PMID: 37604254; PMCID: PMC10591822; DOI: 10.1016/j.mucimm.2023.07.004;
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Banerji R, Grifno GN, Shi L, Smolen D, LeBourdais R, Muhvich J, Eberman C, Hiller BE, Lee J, Regan K, Zheng S, Zhang S, Jiang J, Raslan AA, Breda JC, Pihl R, Traber K, Mazzilli S, Ligresti G, Mizgerd JP, Suki B, Nia HT. Crystal ribcage: a platform for probing real-time lung function at cellular resolution. Nat Methods. 2023 Nov; 20(11):1790-1801.View Related Profiles. PMID: 37710017; PMCID: PMC10860663; DOI: 10.1038/s41592-023-02004-9;
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Showing 10 of 146 results.
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Korkmaz FT, Shenoy AT, Symer EM, Baird LA, Odom CV, Arafa EI, Dimbo EL, Na E, Molina-Arocho W, Brudner M, Standiford TJ, Mehta JL, Sawamura T, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. Lectin-like oxidized low-density lipoprotein receptor 1 attenuates pneumonia-induced lung injury. JCI Insight. 2022 Dec 08; 7(23).View Related Profiles. PMID: 36264633; PMCID: PMC9746901; DOI: 10.1172/jci.insight.149955;
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Serrano GE, Walker JE, Tremblay C, Piras IS, Huentelman MJ, Belden CM, Goldfarb D, Shprecher D, Atri A, Adler CH, Shill HA, Driver-Dunckley E, Mehta SH, Caselli R, Woodruff BK, Haarer CF, Ruhlen T, Torres M, Nguyen S, Schmitt D, Rapscak SZ, Bime C, Peters JL, Alevritis E, Arce RA, Glass MJ, Vargas D, Sue LI, Intorcia AJ, Nelson CM, Oliver J, Russell A, Suszczewicz KE, Borja CI, Cline MP, Hemmingsen SJ, Qiji S, Hobgood HM, Mizgerd JP, Sahoo MK, Zhang H, Solis D, Montine TJ, Berry GJ, Reiman EM, Röltgen K, Boyd SD, Pinsky BA, Zehnder JL, Talbot P, Desforges M, DeTure M, Dickson DW, Beach TG. SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19. J Neuropathol Exp Neurol. 2022 Aug 16; 81(9):666-695. PMID: 35818336; PMCID: PMC9278252; DOI: 10.1093/jnen/nlac056;
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Arafa EI, Shenoy AT, Barker KA, Etesami NS, Martin IM, Lyon De Ana C, Na E, Odom CV, Goltry WN, Korkmaz FT, Wooten AK, Belkina AC, Guillon A, Forsberg EC, Jones MR, Quinton LJ, Mizgerd JP. Recruitment and training of alveolar macrophages after pneumococcal pneumonia. JCI Insight. 2022 Mar 08; 7(5).View Related Profiles. PMID: 35133985; PMCID: PMC8983128; DOI: 10.1172/jci.insight.150239;
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Na E, Allen E, Baird LA, Odom CV, Korkmaz FT, Shenoy AT, Matschulat AM, Jones MR, Kotton DN, Mizgerd JP, Varelas X, Traber KE, Quinton LJ. Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2022 Apr 01; 322(4):L550-L563.View Related Profiles. PMID: 35137631; PMCID: PMC8957336; DOI: 10.1152/ajplung.00325.2021;
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Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2022 02; 66(2):e1-e14. PMID: 35103557; PMCID: PMC8845128; DOI: 10.1165/rcmb.2021-0531ST;
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Murray MP, Crosby CM, Marcovecchio P, Hartmann N, Chandra S, Zhao M, Khurana A, Zahner SP, Clausen BE, Coleman FT, Mizgerd JP, Mikulski Z, Kronenberg M. Stimulation of a subset of natural killer T cells by CD103+ DC is required for GM-CSF and protection from pneumococcal infection. Cell Rep. 2022 01 11; 38(2):110209.View Related Profiles. PMID: 35021099; PMCID: PMC8934033; DOI: 10.1016/j.celrep.2021.110209;
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Shenoy AT, Lyon De Ana C, Barker KA, Arafa EI, Martin IMC, Mizgerd JP, Belkina AC. CPHEN-011: Comprehensive phenotyping of murine lung resident lymphocytes after recovery from pneumococcal pneumonia. Cytometry A. 2022 Nov; 101(11):892-902.View Related Profiles. PMID: 34854229; PMCID: PMC9160214; DOI: 10.1002/cyto.a.24522;
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Shenoy AT, Lyon De Ana C, Arafa EI, Salwig I, Barker KA, Korkmaz FT, Ramanujan A, Etesami NS, Soucy AM, Martin IMC, Tilton BR, Hinds A, Goltry WN, Kathuria H, Braun T, Jones MR, Quinton LJ, Belkina AC, Mizgerd JP. Antigen presentation by lung epithelial cells directs CD4+ TRM cell function and regulates barrier immunity. Nat Commun. 2021 10 05; 12(1):5834.View Related Profiles. PMID: 34611166; PMCID: PMC8492657; DOI: 10.1038/s41467-021-26045-w;
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Odom CV, Kim Y, Burgess CL, Baird LA, Korkmaz FT, Na E, Shenoy AT, Arafa EI, Lam TT, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. Liver-Dependent Lung Remodeling during Systemic Inflammation Shapes Responses to Secondary Infection. J Immunol. 2021 10 01; 207(7):1891-1902.View Related Profiles. PMID: 34470857; PMCID: PMC8631467; DOI: 10.4049/jimmunol.2100254;
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Keefe J, Yao C, Hwang SJ, Courchesne P, Lee GY, Dupuis J, Mizgerd JP, O'Connor G, Washko GR, Cho MH, Silverman EK, Levy D. An Integrative Genomic Strategy Identifies sRAGE as a Causal and Protective Biomarker of Lung Function. Chest. 2022 01; 161(1):76-84.View Related Profiles. PMID: 34237330; PMCID: PMC8783029; DOI: 10.1016/j.chest.2021.06.053;
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Dela Cruz CS, Evans SE, Restrepo MI, Dean N, Torres A, Amara-Elori I, Awasthi S, Caler E, Cao B, Chalmers JD, Chastre J, Cohen TS, Cohen AH, Crothers K, Di YP, Egan ME, Feldman C, Gautam S, Halstead ES, Herold S, Jones BE, Luna C, Niederman MS, Mendez R, Menendez R, Mizgerd JP, Nusrat R, Ramirez J, Shindo Y, Waterer G, Yeligar SM, Wunderink RG. Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2021 07; 18(7):1087-1097. PMID: 34242148; PMCID: PMC8328365; DOI: 10.1513/AnnalsATS.202102-209ST;
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Barker KA, Etesami NS, Shenoy AT, Arafa EI, Lyon de Ana C, Smith NM, Martin IM, Goltry WN, Barron AM, Browning JL, Kathuria H, Belkina AC, Guillon A, Zhong X, Crossland NA, Jones MR, Quinton LJ, Mizgerd JP. Lung-resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021 06 01; 131(11).View Related Profiles. PMID: 34060477; PMCID: PMC8159694; DOI: 10.1172/JCI141810;
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Serrano GE, Walker JE, Arce R, Glass MJ, Vargas D, Sue LI, Intorcia AJ, Nelson CM, Oliver J, Papa J, Russell A, Suszczewicz KE, Borja CI, Belden C, Goldfarb D, Shprecher D, Atri A, Adler CH, Shill HA, Driver-Dunckley E, Mehta SH, Readhead B, Huentelman MJ, Peters JL, Alevritis E, Bimi C, Mizgerd JP, Reiman EM, Montine TJ, Desforges M, Zehnder JL, Sahoo MK, Zhang H, Solis D, Pinsky BA, Deture M, Dickson DW, Beach TG. Mapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 Disease. medRxiv. 2021 Feb 18. PMID: 33619496; PMCID: PMC7899461; DOI: 10.1101/2021.02.15.21251511;
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Beach TG, Russell A, Sue LI, Intorcia AJ, Glass MJ, Walker JE, Arce R, Nelson CM, Hidalgo T, Chiarolanza G, Mariner M, Scroggins A, Pullen J, Souders L, Sivananthan K, Carter N, Saxon-LaBelle M, Hoffman B, Garcia A, Callan M, Fornwalt BE, Carew J, Filon J, Cutler B, Papa J, Curry JR, Oliver J, Shprecher D, Atri A, Belden C, Shill HA, Driver-Dunckley E, Mehta SH, Adler CH, Haarer CF, Ruhlen T, Torres M, Nguyen S, Schmitt D, Fietz M, Lue LF, Walker DG, Mizgerd JP, Serrano GE. Increased Risk of Autopsy-Proven Pneumonia with Sex, Season and Neurodegenerative Disease. medRxiv. 2021 Jan 08. PMID: 33442709; PMCID: PMC7805471; DOI: 10.1101/2021.01.07.21249410;
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Guillon A, Mizgerd JP, Grammatico-Guillon L. 2-year survival among elderly hospitalised for acute respiratory infection versus hip fracture: a useful comparison to raise awareness. Eur Respir Rev. 2020 Dec 31; 29(158). PMID: 33268438; PMCID: PMC9488726; DOI: 10.1183/16000617.0156-2020;
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Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA. Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report. Am J Respir Crit Care Med. 2020 Aug 15; 202(4):511-523. PMID: 32150460; PMCID: PMC7427373; DOI: 10.1164/rccm.201908-1595WS;
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Wooten AK, Shenoy AT, Arafa EI, Akiyama H, Martin IMC, Jones MR, Quinton LJ, Gummuluru S, Bai G, Mizgerd JP. Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses. Front Immunol. 2020; 11:554.View Related Profiles. PMID: 32300347; PMCID: PMC7145409; DOI: 10.3389/fimmu.2020.00554;
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Guillon A, Arafa EI, Barker KA, Belkina AC, Martin I, Shenoy AT, Wooten AK, Lyon De Ana C, Dai A, Labadorf A, Hernandez Escalante J, Dooms H, Blasco H, Traber KE, Jones MR, Quinton LJ, Mizgerd JP. Pneumonia recovery reprograms the alveolar macrophage pool. JCI Insight. 2020 02 27; 5(4).View Related Profiles. PMID: 31990682; PMCID: PMC7101156; DOI: 10.1172/jci.insight.133042;
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Lin WC, Gowdy KM, Madenspacher JH, Zemans RL, Yamamoto K, Lyons-Cohen M, Nakano H, Janardhan K, Williams CJ, Cook DN, Mizgerd JP, Fessler MB. Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace. J Clin Invest. 2020 01 02; 130(1):157-170.View Related Profiles. PMID: 31550239; PMCID: PMC6934223; DOI: 10.1172/JCI127144;
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Shenoy AT, Wasserman GA, Arafa EI, Wooten AK, Smith NMS, Martin IMC, Jones MR, Quinton LJ, Mizgerd JP. Lung CD4+ resident memory T cells remodel epithelial responses to accelerate neutrophil recruitment during pneumonia. Mucosal Immunol. 2020 03; 13(2):334-343.View Related Profiles. PMID: 31748706; PMCID: PMC7044037; DOI: 10.1038/s41385-019-0229-2;
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Kim Y, Allen E, Baird LA, Symer EM, Korkmaz FT, Na E, Odom CV, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. NF-?B RelA Is Required for Hepatoprotection during Pneumonia and Sepsis. Infect Immun. 2019 08; 87(8).View Related Profiles. PMID: 31160364; PMCID: PMC6652780; DOI: 10.1128/IAI.00132-19;
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Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP. Future Research Directions in Pneumonia. NHLBI Working Group Report. Am J Respir Crit Care Med. 2018 07 15; 198(2):256-263.View Related Profiles. PMID: 29546996; PMCID: PMC6058989; DOI: 10.1164/rccm.201801-0139WS;
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Hartmann N, McMurtrey C, Sorensen ML, Huber ME, Kurapova R, Coleman FT, Mizgerd JP, Hildebrand W, Kronenberg M, Lewinsohn DM, Harriff MJ. Riboflavin Metabolism Variation among Clinical Isolates of Streptococcus pneumoniae Results in Differential Activation of Mucosal-associated Invariant T Cells. Am J Respir Cell Mol Biol. 2018 06; 58(6):767-776.View Related Profiles. PMID: 29356555; PMCID: PMC6002660; DOI: 10.1165/rcmb.2017-0290OC;
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Willinger CM, Rong J, Tanriverdi K, Courchesne PL, Huan T, Wasserman GA, Lin H, Dupuis J, Joehanes R, Jones MR, Chen G, Benjamin EJ, O'Connor GT, Mizgerd JP, Freedman JE, Larson MG, Levy D. MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage. Circ Cardiovasc Genet. 2017 Oct; 10(5).View Related Profiles. PMID: 29030400; PMCID: PMC5683429; DOI: 10.1161/CIRCGENETICS.116.001678;
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Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876.View Related Profiles. PMID: 28920925; PMCID: PMC5617666; DOI: 10.1172/JCI94639;
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Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP. Capacity of Pneumococci to Activate Macrophage Nuclear Factor ?B: Influence on Necroptosis and Pneumonia Severity. J Infect Dis. 2017 Aug 15; 216(4):425-435.View Related Profiles. PMID: 28368460; PMCID: PMC6279164; DOI: 10.1093/infdis/jix159;
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Kozlowski E, Wasserman GA, Morgan M, O'Carroll D, Ramirez NP, Gummuluru S, Rah JY, Gower AC, Ieong M, Quinton LJ, Mizgerd JP, Jones MR. The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses. PLoS One. 2017; 12(6):e0179797.View Related Profiles. PMID: 28665939; PMCID: PMC5493306; DOI: 10.1371/journal.pone.0179797;
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Traber KE, Symer EM, Allen E, Kim Y, Hilliard KL, Wasserman GA, Stewart CL, Jones MR, Mizgerd JP, Quinton LJ. Myeloid-epithelial cross talk coordinates synthesis of the tissue-protective cytokine leukemia inhibitory factor during pneumonia. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 01; 313(3):L548-L558.View Related Profiles. PMID: 28522567; PMCID: PMC5625259; DOI: 10.1152/ajplung.00482.2016;
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Smith NM, Wasserman GA, Coleman FT, Hilliard KL, Yamamoto K, Lipsitz E, Malley R, Dooms H, Jones MR, Quinton LJ, Mizgerd JP. Regionally compartmentalized resident memory T cells mediate naturally acquired protection against pneumococcal pneumonia. Mucosal Immunol. 2018 Jan; 11(1):220-235.View Related Profiles. PMID: 28513594; PMCID: PMC5693795; DOI: 10.1038/mi.2017.43;
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Kasotakis G, Galvan M, King E, Sarkar B, Stucchi A, Mizgerd JP, Burke PA, Remick D. Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance. J Trauma Acute Care Surg. 2017 Apr; 82(4):758-765.View Related Profiles. PMID: 28099388; PMCID: PMC5360476; DOI: 10.1097/TA.0000000000001389;
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Gutiérrez-Vázquez C, Enright AJ, Rodríguez-Galán A, Pérez-García A, Collier P, Jones MR, Benes V, Mizgerd JP, Mittelbrunn M, Ramiro AR, Sánchez-Madrid F. 3' Uridylation controls mature microRNA turnover during CD4 T-cell activation. RNA. 2017 Jun; 23(6):882-891.View Related Profiles. PMID: 28351886; PMCID: PMC5435861; DOI: 10.1261/rna.060095.116;
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Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP. The capacity of pneumococci to activate macrophage NF-kB determines necroptosis and pneumonia severity. The Journal of Infectious Diseases. 2017; 216(4). View Publication
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Kamata H, Yamamoto K, Wasserman GA, Zabinski MC, Yuen CK, Lung WY, Gower AC, Belkina AC, Ramirez MI, Deng JC, Quinton LJ, Jones MR, Mizgerd JP. Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia. Am J Respir Cell Mol Biol. 2016 Sep; 55(3):407-18.View Related Profiles. PMID: 27064756; PMCID: PMC5023025; DOI: 10.1165/rcmb.2015-0261OC;
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Stanford EA, Ramirez-Cardenas A, Wang Z, Novikov O, Alamoud K, Koutrakis P, Mizgerd JP, Genco CA, Kukuruzinska M, Monti S, Bais MV, Sherr DH. Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis. Mol Cancer Res. 2016 Aug; 14(8):696-706.View Related Profiles. PMID: 27130942; PMCID: PMC4987205; DOI: 10.1158/1541-7786.MCR-16-0069;
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Traber KE, Hilliard KL, Allen E, Wasserman GA, Yamamoto K, Jones MR, Mizgerd JP, Quinton LJ. Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneumonia. Am J Respir Cell Mol Biol. 2015 Oct; 53(4):479-88.View Related Profiles. PMID: 25692402; PMCID: PMC4742898; DOI: 10.1165/rcmb.2014-0342OC;
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Hilliard KL, Allen E, Traber KE, Yamamoto K, Stauffer NM, Wasserman GA, Jones MR, Mizgerd JP, Quinton LJ. The Lung-Liver Axis: A Requirement for Maximal Innate Immunity and Hepatoprotection during Pneumonia. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):378-90.View Related Profiles. PMID: 25607543; PMCID: PMC4566062; DOI: 10.1165/rcmb.2014-0195OC;
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Hyatt LD, Wasserman GA, Rah YJ, Matsuura KY, Coleman FT, Hilliard KL, Pepper-Cunningham ZA, Ieong M, Stumpo DJ, Blackshear PJ, Quinton LJ, Mizgerd JP, Jones MR. Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection. PLoS One. 2014; 9(10):e109072.View Related Profiles. PMID: 25299049; PMCID: PMC4192124; DOI: 10.1371/journal.pone.0109072;
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Ubags ND, Vernooy JH, Burg E, Hayes C, Bement J, Dilli E, Zabeau L, Abraham E, Poch KR, Nick JA, Dienz O, Zuñiga J, Wargo MJ, Mizgerd JP, Tavernier J, Rincón M, Poynter ME, Wouters EF, Suratt BT. The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med. 2014 Feb; 42(2):e143-51.View Related Profiles. PMID: 24231757; PMCID: PMC3947045; DOI: 10.1097/CCM.0000000000000048;
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Yamamoto K, Ahyi AN, Pepper-Cunningham ZA, Ferrari JD, Wilson AA, Jones MR, Quinton LJ, Mizgerd JP. Roles of lung epithelium in neutrophil recruitment during pneumococcal pneumonia. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):253-62.View Related Profiles. PMID: 24010952; PMCID: PMC3930948; DOI: 10.1165/rcmb.2013-0114OC;
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Ahyi AN, Quinton LJ, Jones MR, Ferrari JD, Pepper-Cunningham ZA, Mella JR, Remick DG, Mizgerd JP. Roles of STAT3 in protein secretion pathways during the acute-phase response. Infect Immun. 2013 May; 81(5):1644-53.View Related Profiles. PMID: 23460517; PMCID: PMC3647986; DOI: 10.1128/IAI.01332-12;
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Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J Clin Invest. 2013 Mar 1; 123(3):1019-31. PMID: 23426178; PMCID: PMC3582130; DOI: 10.1172/JCI64931;
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Wilson AA, Kwok LW, Porter EL, Payne JG, McElroy GS, Ohle SJ, Greenhill SR, Blahna MT, Yamamoto K, Jean JC, Mizgerd JP, Kotton DN. Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages. Mol Ther. 2013 Apr; 21(4):825-33.View Related Profiles. PMID: 23403494; PMCID: PMC3616534; DOI: 10.1038/mt.2013.19;
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Quinton LJ, Mizgerd JP. Mucosal Immunology of Acute Bacterial Pneumonia. Transcriptional Signaling Hubs in Epithelial Cells During Pneumonia. 2013; 159-183. View Publication
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Stanya KJ, Jacobi D, Liu S, Bhargava P, Dai L, Gangl MR, Inouye K, Barlow JL, Ji Y, Mizgerd JP, Qi L, Shi H, McKenzie AN, Lee CH. Direct control of hepatic glucose production by interleukin-13 in mice. J Clin Invest. 2013 Jan 2; 123(1):261-71. PMID: 23257358; PMCID: PMC3533296; DOI: 10.1172/JCI64941;
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Jones MR, Blahna MT, Kozlowski E, Matsuura KY, Ferrari JD, Morris SA, Powers JT, Daley GQ, Quinton LJ, Mizgerd JP. Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival. PLoS Genet. 2012; 8(11):e1003105.View Related Profiles. PMID: 23209448; PMCID: PMC3510031; DOI: 10.1371/journal.pgen.1003105;
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Bartlett NW, Slater L, Glanville N, Haas JJ, Caramori G, Casolari P, Clarke DL, Message SD, Aniscenko J, Kebadze T, Zhu J, Mallia P, Mizgerd JP, Belvisi M, Papi A, Kotenko SV, Johnston SL, Edwards MR. Defining critical roles for NF-?B p65 and type I interferon in innate immunity to rhinovirus. EMBO Mol Med. 2012 Dec; 4(12):1244-60. PMID: 23165884; PMCID: PMC3531601; DOI: 10.1002/emmm.201201650;
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Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. Hepatocyte-specific mutation of both NF-?B RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest. 2012 May 1; 122(5):1758-63.View Related Profiles. PMID: 22466650; PMCID: PMC3336975; DOI: 10.1172/JCI59408;
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Hong Z, Neuhofer P, Liang S, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regner S, Thorlacius H, Saur D, Yoshimura A, Halangk W, Mizgerd JP, Rose-John S, Schmid RM, Algul H. IL-6 Trans-signaling vermittelt über die Aktivierung von Stat3 das letale Lungenversagen der schweren akuten Pankreatitis. Zeitschrift für Gastroenterologie. 2012; 50(8). View Publication
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Hilliard K, Mizgerd JP, Allen E, Jones MR, Quinton LJ. American Thoracic Society 2012 International Conference. The Hepatic Acute Phase Response Regulates Pulmonary Inflammation During Pneumonia. 2012. View Publication
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Hyatt LD, Matsuura KM, Joo Rah Y, Pepper-Cunningham ZA, Ferrari JD, Quinton LJ, Mizgerd JP, Jones MR. American Thoracic Society 2012 International Conference. Myeloid Deficiency Of Brf1 Limits Inflammatory Cytokine MRNA Expression During Pneumonia. 2012. View Publication
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Coleman FT, Blahna MT, Ferrari JD, Pepper-Cunningham ZA, Yamamoto K, Wilson AA, Quinton LJ, Jones MR, Kotton DN, Pelton SI, Mizgerd JP. American Thoracic Society 2012 International Conference. Heterogeneity In Activation Of Macrophage NF-?B By Patient Isolates Of Pneumococci. 2012. View Publication
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Ahyi ANN, Quinton LJ, Jones MR, Ferrari JD, Shen S, Spira A, Mizgerd JP. American Thoracic Society 2012 International Conference. Stat3 Mediates Secretory Protein Expression In The Liver During Pneumonia And ER Stress. 2012. View Publication
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Chinthrajah RS, Govender P, Ferrari JP, Yamamoto K, Ahyi ANN, White MR, Pepper-Cunningham Z, Hartshorn K, Quinton LJ, Mizgerd JP. The Acute Phase Response Limits Inflammatory Cytokine Expression During Influenza Infection. American Thoracic Society 2012 International Conference. 2012. View Publication
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Govender P, Yamamoto K, Ferrari JD, Chinthrajah RS, Pepper-Cunningham ZA, Ahyi ANN, Jones MR, Quinton LJ, Mizgerd JP. American Thoracic Society 2012 International Conference. An Essential Role For Myeloid RelA In Basal Lung Homeostasis. 2012. View Publication
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Pittet LA, Quinton LJ, Yamamoto K, Robson BE, Ferrari JD, Algül H, Schmid RM, Mizgerd JP. Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):573-81.View Related Profiles. PMID: 21216972; PMCID: PMC3175578; DOI: 10.1165/rcmb.2010-0210OC;
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Blahna MT, Jones MR, Quinton LJ, Mizgerd JP. American Thoracic Society 2011 International Conference. Zcchc11 Enhances Cellular Proliferation Independent Of Its Uridyltransferase Activity. 2011. View Publication
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Ferrari JD, Yamamoto K, Blahna MT, Quinton LJ, Jones MR, Mizgerd JP. American Thoracic Society 2011 International Conference. Distinct Roles Of NF-?B RelA In Mediating Cytokine Expression From Type I And Type II Cells In The Lung. 2011. View Publication
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Yamamoto K, Blahna MT, Ferrari JD, Jones MR, Quinton LJ, Mizgerd JP. American Thoracic Society 2011 International Conference. Neutrophils Are Sources Of Lung Cytokines With Distinct Transcription Factor Regulation During Pneumonia. 2011. View Publication
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Coleman FT, Blahna MT, Ferrari JD, Yamamoto K, Wilson AA, Quinton LJ, Jones MR, Kotton DN, Pelton SI, Mizgerd JP. American Thoracic Society 2011 International Conference. Avoiding Or Subverting Macrophage NF-?B Activation As A Virulence Mechanism Of Invasive Pneumococci. 2011. View Publication
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Chinthrajah RS, Govender P, Allen E, Ferrarri JD, Matsuura K, Jones MR, Hartshorn K, Quinton LJ, Mizgerd JP. American Thoracic Society 2011 International Conference. Influenza Pneumonia And The Hepatic Acute Phase Response. 2011. View Publication
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Govender P, Chinthrajah RS, White MR, Blahna MT, Ferrari JD, Quinton LJ, Hartshorn K, Mizgerd JP. American Thoracic Society 2011 International Conference. Roles Of NF-kappaB RelA In Myeloid Cells During Influenza Infection. 2011. View Publication
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Quinton LJ, Mizgerd JP, Jones MR, Allen E. American Journal of Respiratory and Critical Care Medicine. Endogenous Leukemia Inhibitory Factor Limits Acute Lung Injury During Pneumonia. 2011; 183. View Publication
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Ahyi ANN, Quinton LJ, Ferrari JD, Shen S, Jones MR, Spira A, Mizgerd JP. American Thoracic Society 2011 International Conference. Stat3 Is A Key Regulator Of Secretory Protein Expression During Pneumonia-Induced Acute Phase Response And Er Stress. 2011. View Publication
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Perrone LA, Szretter KJ, Katz JM, Mizgerd JP, Tumpey TM. Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus. J Infect Dis. 2010 Oct 15; 202(8):1161-70. PMID: 20815704; PMCID: PMC2941567; DOI: 10.1086/656365;
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Blahna MT, Jones MR, Quinton LJ, Mizgerd JP. The Uridyl-Transferase Enzyme Zcchc11 Prevents Senescence And Promotes Cellular Proliferation. American Thoracic Society 2010 International Conference. 2010. View Publication
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Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Zhang X, Spira A, Mizgerd JP. A Novel Acute Phase-null Mouse Reveals A Critical Role For Liver Products During Pneumonia. American Thoracic Society 2010 International Conference. 2010. View Publication
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Ahyi ANN, Quinton LJ, Ferrari D, Shen S, Spira A, Mizgerd JP. American Thoracic Society 2010 International Conference. Protein Secretory Pathway Induction Is Part Of The Acute Phase Response During Pneumonia. 2010. View Publication
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Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP. Zcchc11-dependent uridylation of microRNA directs cytokine expression. Nat Cell Biol. 2009 Sep; 11(9):1157-63.View Related Profiles. PMID: 19701194; PMCID: PMC2759306; DOI: 10.1038/ncb1931;
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Li Y, Jia Y, Pichavant M, Loison F, Sarraj B, Kasorn A, You J, Robson BE, Umetsu DT, Mizgerd JP, Ye K, Luo HR. Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood. 2009 May 14; 113(20):4930-41.View Related Profiles. PMID: 19286998; PMCID: PMC2686143; DOI: 10.1182/blood-2008-06-161414;
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Blahna MT, Jones MR, Quinton LJ, Mizgerd JP. American Thoracic Society 2009 International Conference. Prevention of Cellular Senescence by the Uridyl Transferase Enzyme Zcchc11. 2009. View Publication
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Jones MR, Quinton LJ, Blahna MT, Mizgerd JP. American Thoracic Society 2009 International Conference. Uridylation of mir-26b Enhances IL-6 Expression. 2009. View Publication
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Quinton LJ, Jones MR, Robson BE, Mizgerd JP. American Thoracic Society 2009 International Conference. Signaling Networks Mediating the Hepatic Acute Phase Response during Bacterial Pneumonia. 2009. View Publication
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Pittet LA, Quinton LJ, Robson BE, Ferrari JD, Algul H, Schmid RM, Mizgerd JP. American Thoracic Society 2009 International Conference. NF-?B RelA Deficiency in Macrophages Delays Response to Pneumococcal Pneumonia. 2009. View Publication
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Huang Y, Zhang J, McHenry KT, Kim MM, Zeng W, Lopez-Pajares V, Dibble CC, Mizgerd JP, Yuan ZM. Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation. Cancer Res. 2008 Nov 15; 68(22):9131-6. PMID: 19010883; PMCID: PMC2717853; DOI: 10.1158/0008-5472.CAN-08-3025;
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Lang JE, Williams ES, Mizgerd JP, Shore SA. Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6. Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5):L1013-20. PMID: 18359888; DOI: 10.1152/ajplung.00122.2007;
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Mizgerd JP, Skerrett SJ. Animal models of human pneumonia. Am J Physiol Lung Cell Mol Physiol. 2008 Mar; 294(3):L387-98. PMID: 18162603
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Nakahira M, Tanaka T, Robson BE, Mizgerd JP, Grusby MJ. Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL. Immunity. 2007 Feb; 26(2):163-76. PMID: 17306571
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Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med. 2006 Jun 12; 203(6):1447-58. PMID: 16702604; PMCID: PMC2118329; DOI: 10.1084/jem.20060375;
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Prince AS, Mizgerd JP, Wiener-Kronish J, Bhattacharya J. Cell signaling underlying the pathophysiology of pneumonia. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L297-300. PMID: 16648241
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Krishnamurthy VM, Quinton LJ, Estroff LA, Metallo SJ, Isaacs JM, Mizgerd JP, Whitesides GM. Promotion of opsonization by antibodies and phagocytosis of Gram-positive bacteria by a bifunctional polyacrylamide. Biomaterials. 2006 Jul; 27(19):3663-74.View Related Profiles. PMID: 16527349
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Jones MR, Quinton LJ, Simms BT, Lupa MM, Kogan MS, Mizgerd JP. Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia. J Infect Dis. 2006 Feb 1; 193(3):360-9.View Related Profiles. PMID: 16388483; PMCID: PMC2674298; DOI: 10.1086/499312;
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Faffe DS, Flynt L, Mellema M, Moore PE, Silverman ES, Subramaniam V, Jones MR, Mizgerd JP, Whitehead T, Imrich A, Panettieri RA, Shore SA. Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13. J Allergy Clin Immunol. 2005 Mar; 115(3):514-20.View Related Profiles. PMID: 15753898
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Johnston RA, Mizgerd JP, Shore SA. CXCR2 is essential for maximal neutrophil recruitment and methacholine responsiveness after ozone exposure. Am J Physiol Lung Cell Mol Physiol. 2005 Jan; 288(1):L61-7. PMID: 15361358
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Mizgerd JP, Lupa MM, Spieker MS. NF-kappaB p50 facilitates neutrophil accumulation during LPS-induced pulmonary inflammation. BMC Immunol. 2004 Jun 9; 5:10. PMID: 15189567; PMCID: PMC449706
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Mizgerd JP, Lupa MM, Hjoberg J, Vallone JC, Warren HB, Butler JP, Silverman ES. Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1302-10. PMID: 14966082
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Wang Q, Doerschuk CM, Mizgerd JP. Neutrophils in innate immunity. Semin Respir Crit Care Med. 2004 Feb; 25(1):33-41. PMID: 16088447
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Mizgerd JP. Competing benefits of tumor necrosis factor-alpha for bacteria and for host defense. Am J Respir Crit Care Med. 2003 Dec 15; 168(12):1410-1. PMID: 14668252
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Mizgerd JP, Lupa MM, Kogan MS, Warren HB, Kobzik L, Topulos GP. Nuclear factor-kappaB p50 limits inflammation and prevents lung injury during Escherichia coli pneumonia. Am J Respir Crit Care Med. 2003 Oct 1; 168(7):810-7. PMID: 12857723
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Mizgerd JP, Spieker MR, Lupa MM. Exon truncation by alternative splicing of murine ICAM-1. Physiol Genomics. 2002 Dec 26; 12(1):47-51. PMID: 12407184
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Mizgerd JP, Scott ML, Spieker MR, Doerschuk CM. Functions of IkappaB proteins in inflammatory responses to Escherichia coli LPS in mouse lungs. Am J Respir Cell Mol Biol. 2002 Nov; 27(5):575-82. PMID: 12397017
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Tasaka S, Richer SE, Mizgerd JP, Doerschuk CM. Very late antigen-4 in CD18-independent neutrophil emigration during acute bacterial pneumonia in mice. Am J Respir Crit Care Med. 2002 Jul 1; 166(1):53-60. PMID: 12091171
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Mizgerd JP. Molecular mechanisms of neutrophil recruitment elicited by bacteria in the lungs. Semin Immunol. 2002 Apr; 14(2):123-32. PMID: 11978084
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Alcamo E, Mizgerd JP, Horwitz BH, Bronson R, Beg AA, Scott M, Doerschuk CM, Hynes RO, Baltimore D. Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol. 2001 Aug 1; 167(3):1592-600. PMID: 11466381
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Huang C, De Sanctis GT, O'Brien PJ, Mizgerd JP, Friend DS, Drazen JM, Brass LF, Stevens RL. Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung. J Biol Chem. 2001 Jul 13; 276(28):26276-84.View Related Profiles. PMID: 11335723
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Mizgerd JP, Spieker MR, Doerschuk CM. Early response cytokines and innate immunity: essential roles for TNF receptor 1 and type I IL-1 receptor during Escherichia coli pneumonia in mice. J Immunol. 2001 Mar 15; 166(6):4042-8. PMID: 11238652
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Horwitz BH, Mizgerd JP, Scott ML, Doerschuk CM. Mechanisms of granulocytosis in the absence of CD18. Blood. 2001 Mar 15; 97(6):1578-83. PMID: 11238094
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Mizgerd JP, Peschon JJ, Doerschuk CM. Roles of tumor necrosis factor receptor signaling during murine Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 2000 Jan; 22(1):85-91. PMID: 10615069
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Palombo JD, DeMichele SJ, Boyce PJ, Lydon EE, Liu JW, Huang YS, Forse RA, Mizgerd JP, Bistrian BR. Effect of short-term enteral feeding with eicosapentaenoic and gamma-linolenic acids on alveolar macrophage eicosanoid synthesis and bactericidal function in rats. Crit Care Med. 1999 Sep; 27(9):1908-15. PMID: 10507617
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Mizgerd JP, Horwitz BH, Quillen HC, Scott ML, Doerschuk CM. Effects of CD18 deficiency on the emigration of murine neutrophils during pneumonia. J Immunol. 1999 Jul 15; 163(2):995-9. PMID: 10395697
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Doerschuk CM, Mizgerd JP, Kubo H, Qin L, Kumasaka T. Adhesion molecules and cellular biomechanical changes in acute lung injury: Giles F. Filley Lecture. Chest. 1999 Jul; 116(1 Suppl):37S-43S. PMID: 10424587
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Mizgerd JP, Bullard DC, Hicks MJ, Beaudet AL, Doerschuk CM. Chronic inflammatory disease alters adhesion molecule requirements for acute neutrophil emigration in mouse skin. J Immunol. 1999 May 1; 162(9):5444-8. PMID: 10228023
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Mizgerd JP, Quinlan WM, LeBlanc BW, Kutkoski GJ, Bullard DC, Beaudet AL, Doerschuk CM. Combinatorial requirements for adhesion molecules in mediating neutrophil emigration during bacterial peritonitis in mice. J Leukoc Biol. 1998 Sep; 64(3):291-7. PMID: 9738654
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Mizgerd JP, Horwitz BH, Bhagwan SD, Scott ML, Beaudet AL, Doerschuk CM. Compromised emigration of CD18-deficient neutrophils during LPS pneumonia in bone marrow chimera mice. 1998.
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Bran JD, Molina RM, Mizgerd JP, Warner AE. Mechanism of gadolinium-induced macrophage inactivation. 1998.
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Mizgerd JP, Kubo H, Kutkoski GJ, Bhagwan SD, Scharffetter-Kochanek K, Beaudet AL, Doerschuk CM. Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. J Exp Med. 1997 Oct 20; 186(8):1357-64. PMID: 9334375; PMCID: PMC2199087
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Mizgerd JP, Meek BB, Kutkoski GJ, Bullard DC, Beaudet AL, Doerschuk CM. Selectins and neutrophil traffic: margination and Streptococcus pneumoniae-induced emigration in murine lungs. J Exp Med. 1996 Aug 1; 184(2):639-45. PMID: 8760817; PMCID: PMC2192708
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Mizgerd JP, Molina RM, Stearns RC, Brain JD, Warner AE. Gadolinium induces macrophage apoptosis. J Leukoc Biol. 1996 Feb; 59(2):189-95. PMID: 8603991
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Mizgerd JP, Kobzik L, Warner AE, Brain JD. Effects of sodium concentration on human neutrophil bactericidal functions. Am J Physiol. 1995 Sep; 269(3 Pt 1):L388-93. PMID: 7573473
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Mizgerd JP, Brain JD. Reactive oxygen species in the killing of Pseudomonas aeruginosa by human leukocytes. Curr Microbiol. 1995 Aug; 31(2):124-8. PMID: 7606187
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 1995 | 2 |
| 1996 | 2 |
| 1997 | 1 |
| 1998 | 3 |
| 1999 | 4 |
| 2000 | 1 |
| 2001 | 4 |
| 2002 | 4 |
| 2003 | 2 |
| 2004 | 4 |
| 2005 | 3 |
| 2006 | 4 |
| 2007 | 5 |
| 2008 | 4 |
| 2009 | 8 |
| 2010 | 5 |
| 2011 | 10 |
| 2012 | 14 |
| 2013 | 4 |
| 2014 | 5 |
| 2015 | 4 |
| 2016 | 2 |
| 2017 | 11 |
| 2018 | 4 |
| 2019 | 3 |
| 2020 | 5 |
| 2021 | 11 |
| 2022 | 7 |
| 2023 | 5 |
| 2024 | 5 |
2023 American Thoracic Society:
Recognition Award for Scientific Accomplishment
2021 BU:
Jerome S. Brody, MD, Professor of Pulmonary Medicine
2021 American Thoracic Society:
Scientific Accomplishment Award for Allergy, Immunology & Inflammation
2020 BU:
University Lecture
2018 American Thoracic Society:
ATS Fellow
2017 NIH:
NHLBI Outstanding Investigator
2017 BUSM Department of Medicine:
Robert Dawson Evans Research Mentoring Award
1999 Francis Families Foundation:
Parker B. Francis Fellow in Pulmonary Research
1998 American Lung Association:
Edward Livingston Trudeau Scholar