Joseph P. Mizgerd, ScD
Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

ScD, Harvard School of Public Health




Our work focuses on immunology in the lung and its influence on acute lower respiratory tract infections. Our research is illuminating the regulation and function of innate and adaptive immune cells and signals in the lung, and how variations in these parameters determine pneumonia susceptibility and outcome. Lung defense consists of immune resistance (the ability to eliminate microbes) and tissue resilience (the ability to prevent or withstand injurious stimuli from infection and inflammation). Both activities are accomplished by the coordinated activities of diverse cell types within the lung, involving some that are constitutively present (including diverse types of epithelial cells, macrophages, lymphocytes, and more) as well as others newly recruited to the infected tissue (including neutrophils plus additional myeloid or lymphoid cells). Effective and productive communication amongst these cells can efficiently destroy microbes without damaging the lung, maintaining respiratory health. Dysregulation of these pathways instead promotes infection (e.g., pneumonia), injury (e.g., the acute respiratory distress syndrome), and other pulmonary diseases. Elucidating factors that differentiate lung infection resistance and susceptibility will enable new approaches to preventing and treating pneumonia.

Director
Boston University School of Medicine
Pulmonary Center


Professor
Boston University School of Medicine
Biochemistry


Professor
Boston University School of Medicine
Microbiology


Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Lung-resident antibacterial heterotypic immunity
07/01/2019 - 06/30/2024 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI115053-06

Pneumonia Biology
01/11/2017 - 12/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
5R35HL135756-04

The B cell repertoire as a window into the nature and impact of the lung virome
05/01/2019 - 04/30/2022 (Multi-PI)
PI: Joseph P. Mizgerd, ScD
NIH/National Heart, Lung, and Blood Institute
5R33HL137081-04

Pneumonia Biology
08/15/2020 - 07/31/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
3R35HL135756-04S1

Biology of the Lung: A Multidisciplinary Program
07/01/2018 - 06/30/2021 (Multi-PI)
PI: Joseph P. Mizgerd, ScD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-45

Biology of the Lung: A Multidisciplinary Program
07/01/2017 - 06/30/2021 (Multi-PI)
PI: Joseph P. Mizgerd, ScD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-42

Biology of the Lung: A Multidisciplinary Program
07/01/2016 - 06/30/2021 (Multi-PI)
PI: Joseph P. Mizgerd, ScD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-42

Noninvasive Quantification of Pulmonary Fibrosis Due to Radiation Induced Lung Injury Using [68Ga]CBP8 Type l Collagen Probe-
10/01/2019 - 07/28/2020 (PI)
The CHEST Foundation


Lung-resident antibacterial heterotypic immunity
07/01/2015 - 06/30/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI115053-04

The B cell repertoire as a window into the nature and impact of the lung virome
05/01/2017 - 04/30/2019 (Multi-PI)
PI: Joseph P. Mizgerd, ScD
NIH/National Heart, Lung, and Blood Institute
5R61HL137081-02

Showing 10 of 16 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2020 The B cell repertoire as a window into the nature and impact of the lung virome 5R33HL137081-04
2020 Pneumonia Biology 5R35HL135756-04 14
2020 Pneumonia Biology 3R35HL135756-04S1 14
2020 Lung-resident antibacterial heterotypic immunity 5R01AI115053-06 12
2020 Biology of the Lung: A Multidisciplinary Program 5T32HL007035-45 121
2019 The B cell repertoire as a window into the nature and impact of the lung virome 4R33HL137081-03
2019 Pneumonia Biology 5R35HL135756-03 14
2019 Pneumonia Biology 5R35HL135756-03 14
2019 Lung-resident antibacterial heterotypic immunity 2R01AI115053-05 12
2019 Biology of the Lung: A Multidisciplinary Program 5T32HL007035-44 121
Showing 10 of 51 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Sagar M, Reifler K, Rossi M, Miller NS, Sinha P, White L, Mizgerd JP. Recent endemic coronavirus infection is associated with less severe COVID-19. J Clin Invest. 2020 Sep 30.View Related Profiles. PMID: 32997649
     
  2. Wooten AK, Shenoy AT, Arafa EI, Akiyama H, Martin IMC, Jones MR, Quinton LJ, Gummuluru S, Bai G, Mizgerd JP. Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses. Front Immunol. 2020; 11:554.View Related Profiles. PMID: 32300347
     
  3. Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, Needham DM, Self WH, Seymour CW, Stapleton RD, Thompson BT, Wunderink RG, Aggarwal NR, Reineck LA. Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report. Am J Respir Crit Care Med. 2020 Mar 09. PMID: 32150460
     
  4. Guillon A, Arafa EI, Barker KA, Belkina AC, Martin I, Shenoy AT, Wooten AK, Lyon De Ana C, Dai A, Labadorf A, Hernandez Escalante J, Dooms H, Blasco H, Traber KE, Jones MR, Quinton LJ, Mizgerd JP. Pneumonia recovery reprograms the alveolar macrophage pool. JCI Insight. 2020 02 27; 5(4).View Related Profiles. PMID: 31990682
     
  5. Lin WC, Gowdy KM, Madenspacher JH, Zemans RL, Yamamoto K, Lyons-Cohen M, Nakano H, Janardhan K, Williams CJ, Cook DN, Mizgerd JP, Fessler MB. Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace. J Clin Invest. 2020 01 02; 130(1):157-170. PMID: 31550239
     
  6. Shenoy AT, Wasserman GA, Arafa EI, Wooten AK, Smith NMS, Martin IMC, Jones MR, Quinton LJ, Mizgerd JP. Lung CD4+ resident memory T cells remodel epithelial responses to accelerate neutrophil recruitment during pneumonia. Mucosal Immunol. 2020 03; 13(2):334-343.View Related Profiles. PMID: 31748706
     
  7. Traber KE, Dimbo EL, Symer EM, Korkmaz FT, Jones MR, Mizgerd JP, Quinton LJ. Roles of interleukin-11 during acute bacterial pneumonia. PLoS One. 2019; 14(8):e0221029.View Related Profiles. PMID: 31415618
     
  8. Kim Y, Allen E, Baird LA, Symer EM, Korkmaz FT, Na E, Odom CV, Jones MR, Mizgerd JP, Traber KE, Quinton LJ. NF-?B RelA Is Required for Hepatoprotection during Pneumonia and Sepsis. Infect Immun. 2019 08; 87(8).View Related Profiles. PMID: 31160364
     
  9. Mizgerd JP. Inflammation and Pneumonia: Why Are Some More Susceptible than Others? Clin Chest Med. 2018 12; 39(4):669-676. PMID: 30390740
     
  10. Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP. Future Research Directions in Pneumonia. NHLBI Working Group Report. Am J Respir Crit Care Med. 2018 07 15; 198(2):256-263.View Related Profiles. PMID: 29546996
     
Showing 10 of 118 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 118 publications over 26 distinct years, with a maximum of 14 publications in 2012

YearPublications
19952
19962
19971
19983
19994
20001
20014
20024
20032
20044
20053
20064
20075
20084
20098
20105
201110
201214
20134
20145
20154
20162
201711
20184
20193
20205
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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