Joseph P. Mizgerd, ScD
Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

ScD, Harvard School of Public Health



Our work focuses on immunology in the lung and its influence on acute lower respiratory tract infections. Our research is illuminating the regulation and function of innate and adaptive immune cells and signals in the lung, and how variations in these parameters determine pneumonia susceptibility and outcome. Lung defense consists of immune resistance (the ability to eliminate microbes) and tissue resilience (the ability to prevent or withstand injurious stimuli from infection and inflammation). Both activities are accomplished by the coordinated activities of diverse cell types within the lung, involving some that are constitutively present (including diverse types of epithelial cells, macrophages, lymphocytes, and more) as well as others newly recruited to the infected tissue (including neutrophils plus additional myeloid or lymphoid cells). Effective and productive communication amongst these cells can efficiently destroy microbes without damaging the lung, maintaining respiratory health. Dysregulation of these pathways instead promotes infection (e.g., pneumonia), injury (e.g., the acute respiratory distress syndrome), and other pulmonary diseases. Elucidating factors that differentiate lung infection resistance and susceptibility will enable new approaches to preventing and treating pneumonia.

Director
Boston University School of Medicine
Pulmonary Center


Professor
Boston University School of Medicine
Biochemistry


Professor
Boston University School of Medicine
Microbiology


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Pneumonia Biology
01/11/2017 - 12/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
5R35HL135756-03

Biology of the Lung: A Multidisciplinary Program
07/01/2018 - 06/30/2021 (Co-PI)
PI: David M. Center, MD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-43

Biology of the Lung: A Multidisciplinary Program
07/01/2017 - 06/30/2021 (Co-PI)
PI: David M. Center, MD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-42

Biology of the Lung: A Multidisciplinary Program
07/01/2016 - 06/30/2021 (Co-PI)
PI: David M. Center, MD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-42

Lung-resident antibacterial heterotypic immunity
07/01/2015 - 06/30/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI115053-04

The B cell repertoire as a window into the nature and impact of the lung virome
05/01/2017 - 04/30/2019 (Co-PI)
PI: Thomas Kepler, PhD
NIH/National Heart, Lung, and Blood Institute
5R61HL137081-02

Macrophage protection in pneumococcal pneumonia
08/20/2016 - 07/31/2018 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R56AI122763-01A1

Biology of the Lung: A Multidisciplinary Program
07/01/2011 - 06/30/2017 (Multi-PI)
PI: Joseph P. Mizgerd, ScD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-40

NF-kB Innate Immunity in the Lungs
08/01/2016 - 12/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
4R01HL068153-13

Cytokine-stimulated systemic defenses during pneumococcal pneumonia
12/01/2004 - 12/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL079392-10

Showing 10 of 12 results. Show All Results



Yr Title Project-Sub Proj Pubs
2019 Pneumonia Biology 5R35HL135756-03 11
2019 Pneumonia Biology 5R35HL135756-03 11
2018 The B cell repertoire as a window into the nature and impact of the lung virome 5R61HL137081-02 3
2018 Pneumonia Biology 5R35HL135756-02 11
2018 Lung-resident antibacterial heterotypic immunity 5R01AI115053-04 7
2018 Biology of the Lung: A Multidisciplinary Program 5T32HL007035-43 67
2017 The B cell repertoire as a window into the nature and impact of the lung virome 1R61HL137081-01 3
2017 Pneumonia Biology 1R35HL135756-01 11
2017 Lung-resident antibacterial heterotypic immunity 5R01AI115053-03 7
2017 Biology of the Lung: A Multidisciplinary Program 5T32HL007035-42 67
Showing 10 of 43 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Mizgerd JP. Inflammation and Pneumonia: Why Are Some More Susceptible than Others? Clin Chest Med. 2018 Dec; 39(4):669-676. PMID: 30390740.
     
  2. Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP. Future Research Directions in Pneumonia. NHLBI Working Group Report. Am J Respir Crit Care Med. 2018 Jul 15; 198(2):256-263.View Related Profiles. PMID: 29546996.
     
  3. Quinton LJ, Walkey AJ, Mizgerd JP. Integrative Physiology of Pneumonia. Physiol Rev. 2018 07 01; 98(3):1417-1464.View Related Profiles. PMID: 29767563.
     
  4. Hartmann N, McMurtrey C, Sorensen ML, Huber ME, Kurapova R, Coleman FT, Mizgerd JP, Hildebrand W, Kronenberg M, Lewinsohn DM, Harriff MJ. Riboflavin Metabolism Variation among Clinical Isolates of Streptococcus pneumoniae Results in Differential Activation of Mucosal-associated Invariant T Cells. Am J Respir Cell Mol Biol. 2018 Jun; 58(6):767-776.View Related Profiles. PMID: 29356555.
     
  5. Willinger CM, Rong J, Tanriverdi K, Courchesne PL, Huan T, Wasserman GA, Lin H, Dupuis J, Joehanes R, Jones MR, Chen G, Benjamin EJ, O'Connor GT, Mizgerd JP, Freedman JE, Larson MG, Levy D. MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage. Circ Cardiovasc Genet. 2017 Oct; 10(5).View Related Profiles. PMID: 29030400.
     
  6. Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876.View Related Profiles. PMID: 28920925.
     
  7. Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP. Capacity of Pneumococci to Activate Macrophage Nuclear Factor ?B: Influence on Necroptosis and Pneumonia Severity. J Infect Dis. 2017 Aug 15; 216(4):425-435.View Related Profiles. PMID: 28368460; DOI: 10.1093/infdis/jix159;.
     
  8. Kasotakis G, Galvan MD, Osathanugrah P, Dharia N, Bufe L, Breed Z, Mizgerd JP, Remick DG. Timing of valproic acid in acute lung injury: prevention is the best therapy? J Surg Res. 2017 Dec; 220:206-212.View Related Profiles. PMID: 29180183.
     
  9. Kozlowski E, Wasserman GA, Morgan M, O'Carroll D, Ramirez NP, Gummuluru S, Rah JY, Gower AC, Ieong M, Quinton LJ, Mizgerd JP, Jones MR. The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses. PLoS One. 2017; 12(6):e0179797.View Related Profiles. PMID: 28665939.
     
  10. Traber KE, Symer EM, Allen E, Kim Y, Hilliard KL, Wasserman GA, Stewart CL, Jones MR, Mizgerd JP, Quinton LJ. Myeloid-epithelial cross talk coordinates synthesis of the tissue-protective cytokine leukemia inhibitory factor during pneumonia. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 01; 313(3):L548-L558.View Related Profiles. PMID: 28522567.
     
Showing 10 of 110 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 110 publications over 24 distinct years, with a maximum of 14 publications in 2012

YearPublications
19952
19962
19971
19983
19994
20001
20014
20024
20032
20044
20053
20064
20075
20084
20098
20105
201110
201214
20134
20145
20154
20162
201711
20184
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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