Joseph P. Mizgerd, ScD
Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine

ScD, Harvard School of Public Health



Acute lower respiratory tract infections cause a terrible public health burden at present, with potential for worse in the coming years. The outcome of these infections is determined by innate immune responses (such as neutrophil recruitment and activation), necessary for host defense but also contributing to lung injury. Innate immune responses in the lungs require the coordinated expression of diverse mediators including adhesion molecules, chemokines, colony stimulating factors, and cytokines that are absent or present only at low levels in uninfected lungs, but are expressed at high levels during infection. Similar mediators are induced during most lung infections, although individual mediators can have different roles during different infections. The coordinated expression suggests programs of gene regulation. NF-kappaB transcription factors are critical to the gene expression program directing innate immunity in the lungs, with RelA inducing innate immunity genes mediating host defense and p50 counteracting this gene induction to prevent lung injury. Other transcription factors are also important, such as STAT3 which both facilitates host defense and limits lung injury. These transcription factors have cell-specific roles during infection, and elucidating unique cell-specific roles in lung innate immunity is a major ongoing effort. Finally, expression of innate immunity mediators is regulated post-transcriptionally as well. MicroRNAs target innate immunity transcripts, and miRNAs themselves are subject to modifications such as uridylation by Zcchc11 to relieve their repressive activities. An improved knowledge of the molecular mechanisms directing innate immunity in the lungs will provide new directions for preventing and curing acute lower respiratory tract infections.

Director
Boston University School of Medicine
Pulmonary Center


Professor
Boston University School of Medicine
Biochemistry


Professor
Boston University School of Medicine
Microbiology


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Pneumonia Biology
01/11/2017 - 12/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
1R35HL135756-01

Biology of the Lung: A Multidisciplinary Program
07/01/2017 - 06/30/2021 (Co-PI)
PI: David M. Center, MD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-42

Biology of the Lung: A Multidisciplinary Program
07/01/2016 - 06/30/2021 (Co-PI)
PI: David M. Center, MD
NIH/National Heart, Lung, and Blood Institute
2T32HL007035-41A1

Lung-resident antibacterial heterotypic immunity
07/01/2015 - 06/30/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI115053-02

The B cell repertoire as a window into the nature and impact of the lung virome
05/01/2017 - 04/30/2019 (Co-PI)
PI: Thomas Kepler, PhD
NIH/National Heart, Lung, and Blood Institute
1R61HL137081-01

Macrophage protection in pneumococcal pneumonia
08/20/2016 - 07/31/2018 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R56AI122763-01A1

Biology of the Lung: A Multidisciplinary Program
07/01/2011 - 06/30/2017 (Multi-PI)
PI: Joseph P. Mizgerd, ScD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-40

NF-kB Innate Immunity in the Lungs
08/01/2016 - 12/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
4R01HL068153-13

Cytokine-stimulated systemic defenses during pneumococcal pneumonia
12/01/2004 - 12/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL079392-10

Vectored Delivery of Oligoclonal Antibodies for Protection Against Enterotoxin Mediated Diarrheal Diseases
02/01/2016 - 11/30/2016 (PI)
University of Massachusetts, Worcester DOD ARO


Showing 10 of 11 results. Show All Results



Yr Title Project-Sub Proj Pubs
2018 Pneumonia Biology 5R35HL135756-02
2017 The B cell repertoire as a window into the nature and impact of the lung virome 1R61HL137081-01
2017 Pneumonia Biology 1R35HL135756-01
2016 Macrophage protection in pneumococcal pneumonia 1R56AI122763-01A1
2016 Lung-resident antibacterial heterotypic immunity 5R01AI115053-02
2016 NF-kB and Innate Immunity in the Lungs 4R01HL068153-13 31
2016 Biology of the Lung: A Multidisciplinary Program 2T32HL007035-41A1 53
2015 Cytokine-stimulated systemic defenses during pneumococcal pneumonia 5R01HL079392-10 26
2015 NF-kB and Innate Immunity in the Lungs 5R01HL068153-12 31
2014 Cytokine-stimulated systemic defenses during pneumococcal pneumonia 5R01HL079392-09 26
Showing 10 of 34 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP. Future Research Directions in Pneumonia: NHLBI Working Group Report. Am J Respir Crit Care Med. 2018 Mar 16.View Related Profiles. PMID: 29546996.
     
  2. Hartmann N, McMurtrey C, Sorensen ML, Huber ME, Kurapova R, Coleman FT, Mizgerd JP, Hildebrand W, Kronenberg M, Lewinsohn DM, Harriff MJ. Riboflavin Metabolism Variation Among Clinical Isolates of Streptococcus pneumoniae Results in Differential Activation of MAIT Cells. Am J Respir Cell Mol Biol. 2018 Jan 22.View Related Profiles. PMID: 29356555.
     
  3. Willinger CM, Rong J, Tanriverdi K, Courchesne PL, Huan T, Wasserman GA, Lin H, Dupuis J, Joehanes R, Jones MR, Chen G, Benjamin EJ, O''Connor GT, Mizgerd JP, Freedman JE, Larson MG, Levy D. MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage. Circ Cardiovasc Genet. 2017 Oct; 10(5).View Related Profiles. PMID: 29030400.
     
  4. Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O''Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876.View Related Profiles. PMID: 28920925.
     
  5. Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP. Capacity of Pneumococci to Activate Macrophage Nuclear Factor ?B: Influence on Necroptosis and Pneumonia Severity. J Infect Dis. 2017 Aug 15; 216(4):425-435.View Related Profiles. PMID: 28368460; DOI: 10.1093/infdis/jix159;.
     
  6. Kasotakis G, Galvan MD, Osathanugrah P, Dharia N, Bufe L, Breed Z, Mizgerd JP, Remick DG. Timing of valproic acid in acute lung injury: prevention is the best therapy? J Surg Res. 2017 Dec; 220:206-212.View Related Profiles. PMID: 29180183.
     
  7. Kozlowski E, Wasserman GA, Morgan M, O''Carroll D, Ramirez NP, Gummuluru S, Rah JY, Gower AC, Ieong M, Quinton LJ, Mizgerd JP, Jones MR. The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses. PLoS One. 2017; 12(6):e0179797.View Related Profiles. PMID: 28665939.
     
  8. Traber KE, Symer EM, Allen E, Kim Y, Hilliard KL, Wasserman GA, Stewart CL, Jones MR, Mizgerd JP, Quinton LJ. Myeloid-epithelial cross talk coordinates synthesis of the tissue-protective cytokine leukemia inhibitory factor during pneumonia. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 01; 313(3):L548-L558.View Related Profiles. PMID: 28522567.
     
  9. Smith NM, Wasserman GA, Coleman FT, Hilliard KL, Yamamoto K, Lipsitz E, Malley R, Dooms H, Jones MR, Quinton LJ, Mizgerd JP. Regionally compartmentalized resident memory T cells mediate naturally acquired protection against pneumococcal pneumonia. Mucosal Immunol. 2018 Jan; 11(1):220-235.View Related Profiles. PMID: 28513594.
     
  10. Mizgerd JP. Pathogenesis of severe pneumonia: advances and knowledge gaps. Curr Opin Pulm Med. 2017 05; 23(3):193-197. PMID: 28221171; DOI: 10.1097/MCP.0000000000000365;.
     
Showing 10 of 82 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 82 publications over 24 distinct years, with a maximum of 10 publications in 2017

YearPublications
19952
19962
19971
19981
19994
20001
20014
20024
20032
20044
20053
20064
20075
20084
20094
20102
20112
20127
20133
20145
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20162
201710
20182
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Acute lower respiratory tract infection
acute lung injury
cell biology
Cytokines
gene expression
Immunity, Innate
Innate immunity
lung infection
macrophages
microRNA
Neutrophil recruitment and activation
neutrophils
Pneumonia
transcription factors
Transcriptional and post-transcriptional regulation of gene expression
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72 E. Concord St Housman (R)
Boston MA 02118
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