Joseph Mizgerd | Profiles RNS

Joseph P. Mizgerd, ScD

Professor

Boston University School of Medicine

Dept of Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

ScD, Harvard School of Public Health

Websites

	Microbiology Faculty
	Pneumonia Biology at BU
	Pulmonary, Allergy, Sleep & Critical Care Medicine Faculty
	Immunology Training Program Faculty
	ResearchGate

ORCID : 0000-0002-4042-3169

Acute lower respiratory tract infections cause a terrible public health burden at present, with potential for worse in the coming years. The outcome of these infections is determined by innate immune responses (such as neutrophil recruitment and activation), necessary for host defense but also contributing to lung injury. Innate immune responses in the lungs require the coordinated expression of diverse mediators including adhesion molecules, chemokines, colony stimulating factors, and cytokines that are absent or present only at low levels in uninfected lungs, but are expressed at high levels during infection. Similar mediators are induced during most lung infections, although individual mediators can have different roles during different infections. The coordinated expression suggests programs of gene regulation. NF-kappaB transcription factors are critical to the gene expression program directing innate immunity in the lungs, with RelA inducing innate immunity genes mediating host defense and p50 counteracting this gene induction to prevent lung injury. Other transcription factors are also important, such as STAT3 which both facilitates host defense and limits lung injury. These transcription factors have cell-specific roles during infection, and elucidating unique cell-specific roles in lung innate immunity is a major ongoing effort. Finally, expression of innate immunity mediators is regulated post-transcriptionally as well. MicroRNAs target innate immunity transcripts, and miRNAs themselves are subject to modifications such as uridylation by Zcchc11 to relieve their repressive activities. An improved knowledge of the molecular mechanisms directing innate immunity in the lungs will provide new directions for preventing and curing acute lower respiratory tract infections.

Director
Boston University School of Medicine
Pulmonary Center

Professor
Boston University School of Medicine
Biochemistry

Professor
Boston University School of Medicine
Microbiology

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

BU Sponsored Research
NIH RePORTER Sponsored Research

PNEUMONIA BIOLOGY
01/11/2017 - 12/31/2023 (PI)
NIH/National Heart, Lung, and Blood Institute
5R35HL135756-02

BIOLOGY OF THE LUNG: A MULTIDISCIPLINARY PROGRAM
07/01/2018 - 06/30/2021 (Co-PI)
PI: David M. Center, MD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-43

BIOLOGY OF THE LUNG: A MULTIDISCIPLINARY PROGRAM
07/01/2017 - 06/30/2021 (Co-PI)
PI: David M. Center, MD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-42

BIOLOGY OF THE LUNG: A MULTIDISCIPLINARY PROGRAM
07/01/2016 - 06/30/2021 (Co-PI)
PI: David M. Center, MD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-42

LUNG-RESIDENT ANTIBACTERIAL HETEROTYPIC IMMUNITY
07/01/2015 - 06/30/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI115053-04

THE B CELL REPERTOIRE AS A WINDOW INTO THE NATURE AND IMPACT OF THE LUNG VIROME
05/01/2017 - 04/30/2019 (Co-PI)
PI: Thomas Kepler, PhD
NIH/National Heart, Lung, and Blood Institute
5R61HL137081-02

MACROPHAGE PROTECTION IN PNEUMOCOCCAL PNEUMONIA
08/20/2016 - 07/31/2018 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R56AI122763-01A1

BIOLOGY OF THE LUNG: A MULTIDISCIPLINARY PROGRAM
07/01/2011 - 06/30/2017 (Multi-PI)
PI: Joseph P. Mizgerd, ScD
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-40

NF-KB INNATE IMMUNITY IN THE LUNGS
08/01/2016 - 12/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
4R01HL068153-13

CYTOKINE-STIMULATED SYSTEMIC DEFENSES DURING PNEUMOCOCCAL PNEUMONIA
12/01/2004 - 12/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL079392-10

Showing 10 of 12 results. Show All Results

Yr	Title	Project-Sub Proj	Pubs
2018	The B cell repertoire as a window into the nature and impact of the lung virome	5R61HL137081-02
2018	Pneumonia Biology	5R35HL135756-02
2018	Lung-resident antibacterial heterotypic immunity	5R01AI115053-04
2018	Biology of the Lung: A Multidisciplinary Program	5T32HL007035-43	53
2017	The B cell repertoire as a window into the nature and impact of the lung virome	1R61HL137081-01
2017	Pneumonia Biology	1R35HL135756-01
2016	Macrophage protection in pneumococcal pneumonia	1R56AI122763-01A1
2016	Lung-resident antibacterial heterotypic immunity	5R01AI115053-02
2016	NF-kB and Innate Immunity in the Lungs	4R01HL068153-13	31
2016	Biology of the Lung: A Multidisciplinary Program	2T32HL007035-41A1	53

Showing 10 of 37 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

Mizgerd JP. Inflammation and Pneumonia: Why Are Some More Susceptible than Others? Clin Chest Med. 2018 Dec; 39(4):669-676. PMID: 30390740.
Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP. Future Research Directions in Pneumonia. NHLBI Working Group Report. Am J Respir Crit Care Med. 2018 Jul 15; 198(2):256-263.View Related Profiles.
Walkey, Allan
Mizgerd, Joseph
PMID: 29546996.
Quinton LJ, Walkey AJ, Mizgerd JP. Integrative Physiology of Pneumonia. Physiol Rev. 2018 Jul 01; 98(3):1417-1464.View Related Profiles.
Walkey, Allan
Mizgerd, Joseph
Quinton, Lee
PMID: 29767563.
Hartmann N, McMurtrey C, Sorensen ML, Huber ME, Kurapova R, Coleman FT, Mizgerd JP, Hildebrand W, Kronenberg M, Lewinsohn DM, Harriff MJ. Riboflavin Metabolism Variation among Clinical Isolates of Streptococcus pneumoniae Results in Differential Activation of Mucosal-associated Invariant T Cells. Am J Respir Cell Mol Biol. 2018 Jun; 58(6):767-776.View Related Profiles.
Coleman, Fadie
Mizgerd, Joseph
PMID: 29356555.
Willinger CM, Rong J, Tanriverdi K, Courchesne PL, Huan T, Wasserman GA, Lin H, Dupuis J, Joehanes R, Jones MR, Chen G, Benjamin EJ, O'Connor GT, Mizgerd JP, Freedman JE, Larson MG, Levy D. MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage. Circ Cardiovasc Genet. 2017 Oct; 10(5).View Related Profiles.
Benjamin, Emelia
O'Connor, George
Wasserman, Gregory
Lin, Honghuang
Dupuis, Josee
Mizgerd, Joseph
Larson, Martin
Jones, Matthew
PMID: 29030400.
Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876.View Related Profiles.
Fine, Alan
Szymaniak, Aleksander
Chen, Felicia
Wasserman, Gregory
Mizgerd, Joseph
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Varelas, Xaralabos
Ai, Xingbin
PMID: 28920925.
Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP. Capacity of Pneumococci to Activate Macrophage Nuclear Factor ?B: Influence on Necroptosis and Pneumonia Severity. J Infect Dis. 2017 Aug 15; 216(4):425-435.View Related Profiles.
Wilson, Andrew
Kotton, Darrell
Coleman, Fadie
Kramnik, Igor
Mizgerd, Joseph
Yamamoto, Kazuko
Quinton, Lee
Jones, Matthew
Pelton, Stephen
PMID: 28368460; DOI: 10.1093/infdis/jix159;.
Kasotakis G, Galvan MD, Osathanugrah P, Dharia N, Bufe L, Breed Z, Mizgerd JP, Remick DG. Timing of valproic acid in acute lung injury: prevention is the best therapy? J Surg Res. 2017 Dec; 220:206-212.View Related Profiles.
Remick, Daniel
Kasotakis, George
Mizgerd, Joseph
PMID: 29180183.
Kozlowski E, Wasserman GA, Morgan M, O'Carroll D, Ramirez NP, Gummuluru S, Rah JY, Gower AC, Ieong M, Quinton LJ, Mizgerd JP, Jones MR. The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses. PLoS One. 2017; 12(6):e0179797.View Related Profiles.
Gower, Adam
Kozlowski, Elyse
Wasserman, Gregory
Mizgerd, Joseph
Quinton, Lee
Jones, Matthew
Ieong, Michael
Gummuluru, Suryaram
PMID: 28665939.
Traber KE, Symer EM, Allen E, Kim Y, Hilliard KL, Wasserman GA, Stewart CL, Jones MR, Mizgerd JP, Quinton LJ. Myeloid-epithelial cross talk coordinates synthesis of the tissue-protective cytokine leukemia inhibitory factor during pneumonia. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 01; 313(3):L548-L558.View Related Profiles.
Wasserman, Gregory
Mizgerd, Joseph
Traber, Katrina
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Kim, Yuri
PMID: 28522567.

Showing 10 of 110 results. Show More

Smith NM, Wasserman GA, Coleman FT, Hilliard KL, Yamamoto K, Lipsitz E, Malley R, Dooms H, Jones MR, Quinton LJ, Mizgerd JP. Regionally compartmentalized resident memory T cells mediate naturally acquired protection against pneumococcal pneumonia. Mucosal Immunol. 2018 Jan; 11(1):220-235.View Related Profiles.
Coleman, Fadie
Wasserman, Gregory
Dooms, Hans
Mizgerd, Joseph
Yamamoto, Kazuko
Hilliard, Kristie
Quinton, Lee
PMID: 28513594.
Mizgerd JP. Pathogenesis of severe pneumonia: advances and knowledge gaps. Curr Opin Pulm Med. 2017 05; 23(3):193-197. PMID: 28221171; DOI: 10.1097/MCP.0000000000000365;.
Kasotakis G, Galvan M, King E, Sarkar B, Stucchi A, Mizgerd JP, Burke PA, Remick D. Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance. J Trauma Acute Care Surg. 2017 Apr; 82(4):758-765.View Related Profiles.
Sarkar, Bedabrata
Remick, Daniel
King, Elizabeth
Kasotakis, George
Mizgerd, Joseph
Burke, Peter
PMID: 28099388; DOI: 10.1097/TA.0000000000001389;.
Gutiérrez-Vázquez C, Enright AJ, Rodríguez-Galán A, Pérez-García A, Collier P, Jones MR, Benes V, Mizgerd JP, Mittelbrunn M, Ramiro AR, Sánchez-Madrid F. 3' Uridylation controls mature microRNA turnover during CD4 T-cell activation. RNA. 2017 Jun; 23(6):882-891.View Related Profiles.
Mizgerd, Joseph
Jones, Matthew
PMID: 28351886; DOI: 10.1261/rna.060095.116;.
Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP. The capacity of pneumococci to activate macrophage NF-kB determines necroptosis and pneumonia severity. The Journal of Infectious Diseases. 2017; 216(4). View Publication
Kamata H, Yamamoto K, Wasserman GA, Zabinski MC, Yuen CK, Lung WY, Gower AC, Belkina AC, Ramirez MI, Deng JC, Quinton LJ, Jones MR, Mizgerd JP. Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia. Am J Respir Cell Mol Biol. 2016 Sep; 55(3):407-18.View Related Profiles.
Gower, Adam
Belkina, Anna
Wasserman, Gregory
Mizgerd, Joseph
Quinton, Lee
Ramirez, Maria
Jones, Matthew
PMID: 27064756; PMCID: PMC5023025; DOI: 10.1165/rcmb.2015-0261OC;.
Stanford EA, Ramirez-Cardenas A, Wang Z, Novikov O, Alamoud K, Koutrakis P, Mizgerd JP, Genco CA, Kukuruzinska M, Monti S, Bais MV, Sherr DH. Role for the Aryl Hydrocarbon Receptor and Diverse Ligands in Oral Squamous Cell Carcinoma Migration and Tumorigenesis. Mol Cancer Res. 2016 Aug; 14(8):696-706.View Related Profiles.
Sherr, David
Stanford, Elizabeth
Mizgerd, Joseph
Bais, Manish
Kukuruzinska, Maria
Novikov, Olga
Monti, Stefano
Wang, Zhongyan
PMID: 27130942; PMCID: PMC4987205; DOI: 10.1158/1541-7786.MCR-16-0069;.
Mizgerd JP. Community-Acquired Pneumonia Requiring Hospitalization. N Engl J Med. 2015 Dec 10; 373(24):2380. PMID: 26650160; DOI: 10.1056/NEJMc1511751#SA1;.
Traber KE, Hilliard KL, Allen E, Wasserman GA, Yamamoto K, Jones MR, Mizgerd JP, Quinton LJ. Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneumonia. Am J Respir Cell Mol Biol. 2015 Oct; 53(4):479-88.View Related Profiles.
Wasserman, Gregory
Mizgerd, Joseph
Traber, Katrina
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
PMID: 25692402; PMCID: PMC4742898; DOI: 10.1165/rcmb.2014-0342OC;.
Hilliard KL, Allen E, Traber KE, Yamamoto K, Stauffer NM, Wasserman GA, Jones MR, Mizgerd JP, Quinton LJ. The Lung-Liver Axis: A Requirement for Maximal Innate Immunity and Hepatoprotection during Pneumonia. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):378-90.View Related Profiles.
Wasserman, Gregory
Mizgerd, Joseph
Traber, Katrina
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Stauffer, Nicole
PMID: 25607543; PMCID: PMC4566062; DOI: 10.1165/rcmb.2014-0195OC;.
Hilliard KL, Allen E, Traber KE, Kim Y, Wasserman GA, Jones MR, Mizgerd JP, Quinton LJ. Activation of Hepatic STAT3 Maintains Pulmonary Defense during Endotoxemia. Infect Immun. 2015 Oct; 83(10):4015-27.View Related Profiles.
Wasserman, Gregory
Mizgerd, Joseph
Traber, Katrina
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Kim, Yuri
PMID: 26216424; PMCID: PMC4567648; DOI: 10.1128/IAI.00464-15;.
Mizgerd JP. The infant nose. Introducing the respiratory tract to the world. Am J Respir Crit Care Med. 2014 Dec 1; 190(11):1206-7. PMID: 25436779; PMCID: PMC4315821; DOI: 10.1164/rccm.201410-1919ED;.
Hyatt LD, Wasserman GA, Rah YJ, Matsuura KY, Coleman FT, Hilliard KL, Pepper-Cunningham ZA, Ieong M, Stumpo DJ, Blackshear PJ, Quinton LJ, Mizgerd JP, Jones MR. Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection. PLoS One. 2014; 9(10):e109072.View Related Profiles.
Coleman, Fadie
Wasserman, Gregory
Mizgerd, Joseph
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Ieong, Michael
PMID: 25299049; PMCID: PMC4192124; DOI: 10.1371/journal.pone.0109072;.
Quinton LJ, Mizgerd JP. Dynamics of lung defense in pneumonia: resistance, resilience, and remodeling. Annu Rev Physiol. 2015; 77:407-30.View Related Profiles.
Mizgerd, Joseph
Quinton, Lee
PMID: 25148693; PMCID: PMC4366440; DOI: 10.1146/annurev-physiol-021014-071937;.
Yamamoto K, Ahyi AN, Pepper-Cunningham ZA, Ferrari JD, Wilson AA, Jones MR, Quinton LJ, Mizgerd JP. Roles of lung epithelium in neutrophil recruitment during pneumococcal pneumonia. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):253-62.View Related Profiles.
Wilson, Andrew
Ahyi, Ayele-Nati
Mizgerd, Joseph
Yamamoto, Kazuko
Quinton, Lee
Jones, Matthew
PMID: 24010952; PMCID: PMC3930948; DOI: 10.1165/rcmb.2013-0114OC;.
Ubags ND, Vernooy JH, Burg E, Hayes C, Bement J, Dilli E, Zabeau L, Abraham E, Poch KR, Nick JA, Dienz O, Zuñiga J, Wargo MJ, Mizgerd JP, Tavernier J, Rincón M, Poynter ME, Wouters EF, Suratt BT. The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med. 2014 Feb; 42(2):e143-51.View Related Profiles.
Hayes, Catherine
Mizgerd, Joseph
PMID: 24231757; PMCID: PMC3947045; DOI: 10.1097/CCM.0000000000000048;.
Ahyi AN, Quinton LJ, Jones MR, Ferrari JD, Pepper-Cunningham ZA, Mella JR, Remick DG, Mizgerd JP. Roles of STAT3 in protein secretion pathways during the acute-phase response. Infect Immun. 2013 May; 81(5):1644-53.View Related Profiles.
Ahyi, Ayele-Nati
Remick, Daniel
Mizgerd, Joseph
Mella, Juan
Quinton, Lee
Jones, Matthew
PMID: 23460517; PMCID: PMC3647986; DOI: 10.1128/IAI.01332-12;.
Zhang H, Neuhöfer P, Song L, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regnér S, Thorlacius H, Saur D, Weirich G, Yoshimura A, Halangk W, Mizgerd JP, Schmid RM, Rose-John S, Algül H. IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality. J Clin Invest. 2013 Mar 1; 123(3):1019-31. PMID: 23426178; PMCID: PMC3582130; DOI: 10.1172/JCI64931;.
Wilson AA, Kwok LW, Porter EL, Payne JG, McElroy GS, Ohle SJ, Greenhill SR, Blahna MT, Yamamoto K, Jean JC, Mizgerd JP, Kotton DN. Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages. Mol Ther. 2013 Apr; 21(4):825-33.View Related Profiles.
Wilson, Andrew
Kotton, Darrell
Mizgerd, Joseph
Jean, Jyh-Chang
Yamamoto, Kazuko
PMID: 23403494; PMCID: PMC3616534; DOI: 10.1038/mt.2013.19;.
Quinton LJ, Mizgerd JP. Mucosal Immunology of Acute Bacterial Pneumonia. Transcriptional Signaling Hubs in Epithelial Cells During Pneumonia. 2013; 159-183. View Publication
Stanya KJ, Jacobi D, Liu S, Bhargava P, Dai L, Gangl MR, Inouye K, Barlow JL, Ji Y, Mizgerd JP, Qi L, Shi H, McKenzie AN, Lee CH. Direct control of hepatic glucose production by interleukin-13 in mice. J Clin Invest. 2013 Jan 2; 123(1):261-71. PMID: 23257358; PMCID: PMC3533296; DOI: 10.1172/JCI64941;.
Jones MR, Blahna MT, Kozlowski E, Matsuura KY, Ferrari JD, Morris SA, Powers JT, Daley GQ, Quinton LJ, Mizgerd JP. Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival. PLoS Genet. 2012; 8(11):e1003105.View Related Profiles.
Kozlowski, Elyse
Mizgerd, Joseph
Quinton, Lee
Jones, Matthew
PMID: 23209448; PMCID: PMC3510031; DOI: 10.1371/journal.pgen.1003105;.
Bartlett NW, Slater L, Glanville N, Haas JJ, Caramori G, Casolari P, Clarke DL, Message SD, Aniscenko J, Kebadze T, Zhu J, Mallia P, Mizgerd JP, Belvisi M, Papi A, Kotenko SV, Johnston SL, Edwards MR. Defining critical roles for NF-?B p65 and type I interferon in innate immunity to rhinovirus. EMBO Mol Med. 2012 Dec; 4(12):1244-60. PMID: 23165884; PMCID: PMC3531601; DOI: 10.1002/emmm.201201650;.
Yamamoto K, Ferrari JD, Cao Y, Ramirez MI, Jones MR, Quinton LJ, Mizgerd JP. Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia. J Immunol. 2012 Sep 1; 189(5):2450-9.View Related Profiles.
Mizgerd, Joseph
Yamamoto, Kazuko
Quinton, Lee
Ramirez, Maria
Jones, Matthew
Cao, Yu-Xia
PMID: 22844121; PMCID: PMC3424336; DOI: 10.4049/jimmunol.1200634;.
Mizgerd JP. Respiratory infection and the impact of pulmonary immunity on lung health and disease. Am J Respir Crit Care Med. 2012 Nov 1; 186(9):824-9. PMID: 22798317; PMCID: PMC3530220; DOI: 10.1164/rccm.201206-1063PP;.
Quinton LJ, Mizgerd JP, Hilliard KL, Jones MR, Kwon CY, Allen E. Leukemia inhibitory factor signaling is required for lung protection during pneumonia. J Immunol. 2012 Jun 15; 188(12):6300-8.View Related Profiles.
Mizgerd, Joseph
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
PMID: 22581855; PMCID: PMC3370070; DOI: 10.4049/jimmunol.1200256;.
Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. Hepatocyte-specific mutation of both NF-?B RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest. 2012 May 1; 122(5):1758-63.View Related Profiles.
Spira, Avrum
Mizgerd, Joseph
Hilliard, Kristie
Quinton, Lee
Jones, Matthew
Pelton, Stephen
Sabharwal, Vishakha
PMID: 22466650; PMCID: PMC3336975; DOI: 10.1172/JCI59408;.
Ahyi ANN, Quinton LJ, Jones MR, Ferrari JD, Shen S, Spira A, Mizgerd JP. American Thoracic Society 2012 International Conference. Stat3 Mediates Secretory Protein Expression In The Liver During Pneumonia And ER Stress. 2012. View Publication
Hyatt LD, Matsuura KM, Joo Rah Y, Pepper-Cunningham ZA, Ferrari JD, Quinton LJ, Mizgerd JP, Jones MR. American Thoracic Society 2012 International Conference. Myeloid Deficiency Of Brf1 Limits Inflammatory Cytokine MRNA Expression During Pneumonia. 2012. View Publication
Chinthrajah RS, Govender P, Ferrari JP, Yamamoto K, Ahyi ANN, White MR, Pepper-Cunningham Z, Hartshorn K, Quinton LJ, Mizgerd JP. The Acute Phase Response Limits Inflammatory Cytokine Expression During Influenza Infection. American Thoracic Society 2012 International Conference. 2012. View Publication
Govender P, Yamamoto K, Ferrari JD, Chinthrajah RS, Pepper-Cunningham ZA, Ahyi ANN, Jones MR, Quinton LJ, Mizgerd JP. American Thoracic Society 2012 International Conference. An Essential Role For Myeloid RelA In Basal Lung Homeostasis. 2012. View Publication
Hong Z, Neuhofer P, Liang S, Rabe B, Lesina M, Kurkowski MU, Treiber M, Wartmann T, Regner S, Thorlacius H, Saur D, Yoshimura A, Halangk W, Mizgerd JP, Rose-John S, Schmid RM, Algul H. IL-6 Trans-signaling vermittelt über die Aktivierung von Stat3 das letale Lungenversagen der schweren akuten Pankreatitis. Zeitschrift für Gastroenterologie. 2012; 50(8). View Publication
Coleman FT, Blahna MT, Ferrari JD, Pepper-Cunningham ZA, Yamamoto K, Wilson AA, Quinton LJ, Jones MR, Kotton DN, Pelton SI, Mizgerd JP. American Thoracic Society 2012 International Conference. Heterogeneity In Activation Of Macrophage NF-?B By Patient Isolates Of Pneumococci. 2012. View Publication
Hilliard K, Mizgerd JP, Allen E, Jones MR, Quinton LJ. American Thoracic Society 2012 International Conference. The Hepatic Acute Phase Response Regulates Pulmonary Inflammation During Pneumonia. 2012. View Publication
Blahna MT, Jones MR, Quinton LJ, Matsuura KY, Mizgerd JP. Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity. J Biol Chem. 2011 Dec 9; 286(49):42381-9.View Related Profiles.
Mizgerd, Joseph
Quinton, Lee
Jones, Matthew
PMID: 22006926; PMCID: PMC3234974; DOI: 10.1074/jbc.M111.259689;.
Pittet LA, Quinton LJ, Yamamoto K, Robson BE, Ferrari JD, Algül H, Schmid RM, Mizgerd JP. Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):573-81.View Related Profiles.
Mizgerd, Joseph
Yamamoto, Kazuko
Quinton, Lee
PMID: 21216972; PMCID: PMC3175578; DOI: 10.1165/rcmb.2010-0210OC;.
Ferrari JD, Yamamoto K, Blahna MT, Quinton LJ, Jones MR, Mizgerd JP. American Thoracic Society 2011 International Conference. Distinct Roles Of NF-?B RelA In Mediating Cytokine Expression From Type I And Type II Cells In The Lung. 2011. View Publication
Quinton LJ, Mizgerd JP, Jones MR, Allen E. American Journal of Respiratory and Critical Care Medicine. Endogenous Leukemia Inhibitory Factor Limits Acute Lung Injury During Pneumonia. 2011; 183. View Publication
Coleman FT, Blahna MT, Ferrari JD, Yamamoto K, Wilson AA, Quinton LJ, Jones MR, Kotton DN, Pelton SI, Mizgerd JP. American Thoracic Society 2011 International Conference. Avoiding Or Subverting Macrophage NF-?B Activation As A Virulence Mechanism Of Invasive Pneumococci. 2011. View Publication
Ahyi ANN, Quinton LJ, Ferrari JD, Shen S, Jones MR, Spira A, Mizgerd JP. American Thoracic Society 2011 International Conference. Stat3 Is A Key Regulator Of Secretory Protein Expression During Pneumonia-Induced Acute Phase Response And Er Stress. 2011. View Publication
Yamamoto K, Blahna MT, Ferrari JD, Jones MR, Quinton LJ, Mizgerd JP. American Thoracic Society 2011 International Conference. Neutrophils Are Sources Of Lung Cytokines With Distinct Transcription Factor Regulation During Pneumonia. 2011. View Publication
Blahna MT, Jones MR, Quinton LJ, Mizgerd JP. American Thoracic Society 2011 International Conference. Zcchc11 Enhances Cellular Proliferation Independent Of Its Uridyltransferase Activity. 2011. View Publication
Chinthrajah RS, Govender P, Allen E, Ferrarri JD, Matsuura K, Jones MR, Hartshorn K, Quinton LJ, Mizgerd JP. American Thoracic Society 2011 International Conference. Influenza Pneumonia And The Hepatic Acute Phase Response. 2011. View Publication
Govender P, Chinthrajah RS, White MR, Blahna MT, Ferrari JD, Quinton LJ, Hartshorn K, Mizgerd JP. American Thoracic Society 2011 International Conference. Roles Of NF-kappaB RelA In Myeloid Cells During Influenza Infection. 2011. View Publication
Perrone LA, Szretter KJ, Katz JM, Mizgerd JP, Tumpey TM. Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus. J Infect Dis. 2010 Oct 15; 202(8):1161-70. PMID: 20815704; PMCID: PMC2941567; DOI: 10.1086/656365;.
Quinton LJ, Mizgerd JP. NF-?B and STAT3 signaling hubs for lung innate immunity. Cell Tissue Res. 2011 Jan; 343(1):153-65.View Related Profiles.
Mizgerd, Joseph
Quinton, Lee
PMID: 20872151; DOI: 10.1007/s00441-010-1044-y;.
Ahyi ANN, Quinton LJ, Ferrari D, Shen S, Spira A, Mizgerd JP. American Thoracic Society 2010 International Conference. Protein Secretory Pathway Induction Is Part Of The Acute Phase Response During Pneumonia. 2010. View Publication
Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Zhang X, Spira A, Mizgerd JP. A Novel Acute Phase-null Mouse Reveals A Critical Role For Liver Products During Pneumonia. American Thoracic Society 2010 International Conference. 2010. View Publication
Blahna MT, Jones MR, Quinton LJ, Mizgerd JP. The Uridyl-Transferase Enzyme Zcchc11 Prevents Senescence And Promotes Cellular Proliferation. American Thoracic Society 2010 International Conference. 2010. View Publication
Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP. Zcchc11-dependent uridylation of microRNA directs cytokine expression. Nat Cell Biol. 2009 Sep; 11(9):1157-63.View Related Profiles.
Mizgerd, Joseph
Quinton, Lee
Jones, Matthew
PMID: 19701194; PMCID: PMC2759306; DOI: 10.1038/ncb1931;.
Quinton LJ, Jones MR, Robson BE, Mizgerd JP. Mechanisms of the hepatic acute-phase response during bacterial pneumonia. Infect Immun. 2009 Jun; 77(6):2417-26.View Related Profiles.
Mizgerd, Joseph
Quinton, Lee
Jones, Matthew
PMID: 19289507; PMCID: PMC2687329; DOI: 10.1128/IAI.01300-08;.
Li Y, Jia Y, Pichavant M, Loison F, Sarraj B, Kasorn A, You J, Robson BE, Umetsu DT, Mizgerd JP, Ye K, Luo HR. Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood. 2009 May 14; 113(20):4930-41. PMID: 19286998; PMCID: PMC2686143; DOI: 10.1182/blood-2008-06-161414;.
Gamble L, Bagby GJ, Quinton LJ, Happel KI, Mizgerd JP, Zhang P, Nelson S. The systemic and pulmonary LPS binding protein response to intratracheal lipopolysaccharide. Shock. 2009 Feb; 31(2):212-7.View Related Profiles.
Mizgerd, Joseph
Quinton, Lee
PMID: 18520704; DOI: 10.1097/SHK.0b013e31817c0d7d;.
Pittet LA, Quinton LJ, Robson BE, Ferrari JD, Algul H, Schmid RM, Mizgerd JP. American Thoracic Society 2009 International Conference. NF-?B RelA Deficiency in Macrophages Delays Response to Pneumococcal Pneumonia. 2009. View Publication
Quinton LJ, Jones MR, Robson BE, Mizgerd JP. American Thoracic Society 2009 International Conference. Signaling Networks Mediating the Hepatic Acute Phase Response during Bacterial Pneumonia. 2009. View Publication
Jones MR, Quinton LJ, Blahna MT, Mizgerd JP. American Thoracic Society 2009 International Conference. Uridylation of mir-26b Enhances IL-6 Expression. 2009. View Publication
Blahna MT, Jones MR, Quinton LJ, Mizgerd JP. American Thoracic Society 2009 International Conference. Prevention of Cellular Senescence by the Uridyl Transferase Enzyme Zcchc11. 2009. View Publication
Huang Y, Zhang J, McHenry KT, Kim MM, Zeng W, Lopez-Pajares V, Dibble CC, Mizgerd JP, Yuan ZM. Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation. Cancer Res. 2008 Nov 15; 68(22):9131-6. PMID: 19010883; PMCID: PMC2717853; DOI: 10.1158/0008-5472.CAN-08-3025;.
Lang JE, Williams ES, Mizgerd JP, Shore SA. Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6. Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5):L1013-20. PMID: 18359888; DOI: 10.1152/ajplung.00122.2007;.
Mizgerd JP. Acute lower respiratory tract infection. N Engl J Med. 2008 Feb 14; 358(7):716-27. PMID: 18272895; PMCID: PMC2711392; DOI: 10.1056/NEJMra074111;.
Quinton LJ, Jones MR, Robson BE, Simms BT, Whitsett JA, Mizgerd JP. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):699-706.View Related Profiles.
Mizgerd, Joseph
Quinton, Lee
Jones, Matthew
PMID: 18192501; PMCID: PMC2396249; DOI: 10.1165/rcmb.2007-0365OC;.
Mizgerd JP, Skerrett SJ. Animal models of human pneumonia. Am J Physiol Lung Cell Mol Physiol. 2008 Mar; 294(3):L387-98. PMID: 18162603.
Johnston RA, Mizgerd JP, Flynt L, Quinton LJ, Williams ES, Shore SA. Type I interleukin-1 receptor is required for pulmonary responses to subacute ozone exposure in mice. Am J Respir Cell Mol Biol. 2007 Oct; 37(4):477-84.View Related Profiles.
Mizgerd, Joseph
Quinton, Lee
PMID: 17575079; PMCID: PMC2176124.
Quinton LJ, Jones MR, Simms BT, Kogan MS, Robson BE, Skerrett SJ, Mizgerd JP. Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia. J Immunol. 2007 Feb 1; 178(3):1896-903.View Related Profiles.
Mizgerd, Joseph
Quinton, Lee
Jones, Matthew
PMID: 17237440; PMCID: PMC2674289.
Nakahira M, Tanaka T, Robson BE, Mizgerd JP, Grusby MJ. Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL. Immunity. 2007 Feb; 26(2):163-76. PMID: 17306571.
Subramanian KK, Jia Y, Zhu D, Simms BT, Jo H, Hattori H, You J, Mizgerd JP, Luo HR. Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood. 2007 May 1; 109(9):4028-37. PMID: 17202315; PMCID: PMC1874585.
Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med. 2006 Jun 12; 203(6):1447-58. PMID: 16702604; PMCID: PMC2118329.
Prince AS, Mizgerd JP, Wiener-Kronish J, Bhattacharya J. Cell signaling underlying the pathophysiology of pneumonia. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L297-300. PMID: 16648241.
Krishnamurthy VM, Quinton LJ, Estroff LA, Metallo SJ, Isaacs JM, Mizgerd JP, Whitesides GM. Promotion of opsonization by antibodies and phagocytosis of Gram-positive bacteria by a bifunctional polyacrylamide. Biomaterials. 2006 Jul; 27(19):3663-74.View Related Profiles.
Mizgerd, Joseph
Quinton, Lee
PMID: 16527349.
Mizgerd JP. Lung infection--a public health priority. PLoS Med. 2006 Feb; 3(2):e76. PMID: 16401173; PMCID: PMC1326257.
Jones MR, Quinton LJ, Simms BT, Lupa MM, Kogan MS, Mizgerd JP. Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia. J Infect Dis. 2006 Feb 1; 193(3):360-9.View Related Profiles.
Mizgerd, Joseph
Quinton, Lee
Jones, Matthew
PMID: 16388483; PMCID: PMC2674298.
Jones MR, Simms BT, Lupa MM, Kogan MS, Mizgerd JP. Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. J Immunol. 2005 Dec 1; 175(11):7530-5.View Related Profiles.
Mizgerd, Joseph
Jones, Matthew
PMID: 16301661; PMCID: PMC2723739.
Faffe DS, Flynt L, Mellema M, Moore PE, Silverman ES, Subramaniam V, Jones MR, Mizgerd JP, Whitehead T, Imrich A, Panettieri RA, Shore SA. Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13. J Allergy Clin Immunol. 2005 Mar; 115(3):514-20.View Related Profiles.
Mizgerd, Joseph
Jones, Matthew
PMID: 15753898.
Johnston RA, Mizgerd JP, Shore SA. CXCR2 is essential for maximal neutrophil recruitment and methacholine responsiveness after ozone exposure. Am J Physiol Lung Cell Mol Physiol. 2005 Jan; 288(1):L61-7. PMID: 15361358.
Mizgerd JP, Lupa MM, Spieker MS. NF-kappaB p50 facilitates neutrophil accumulation during LPS-induced pulmonary inflammation. BMC Immunol. 2004 Jun 9; 5:10. PMID: 15189567; PMCID: PMC449706.
Mizgerd JP, Lupa MM, Hjoberg J, Vallone JC, Warren HB, Butler JP, Silverman ES. Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1. Am J Physiol Lung Cell Mol Physiol. 2004 Jun; 286(6):L1302-10. PMID: 14966082.
Wang Q, Doerschuk CM, Mizgerd JP. Neutrophils in innate immunity. Semin Respir Crit Care Med. 2004 Feb; 25(1):33-41. PMID: 16088447.
Mizgerd JP. Competing benefits of tumor necrosis factor-alpha for bacteria and for host defense. Am J Respir Crit Care Med. 2003 Dec 15; 168(12):1410-1. PMID: 14668252.
Mizgerd JP, Lupa MM, Kogan MS, Warren HB, Kobzik L, Topulos GP. Nuclear factor-kappaB p50 limits inflammation and prevents lung injury during Escherichia coli pneumonia. Am J Respir Crit Care Med. 2003 Oct 1; 168(7):810-7. PMID: 12857723.
Mizgerd JP, Spieker MR, Lupa MM. Exon truncation by alternative splicing of murine ICAM-1. Physiol Genomics. 2002 Dec 26; 12(1):47-51. PMID: 12407184.
Mizgerd JP, Scott ML, Spieker MR, Doerschuk CM. Functions of IkappaB proteins in inflammatory responses to Escherichia coli LPS in mouse lungs. Am J Respir Cell Mol Biol. 2002 Nov; 27(5):575-82. PMID: 12397017.
Tasaka S, Richer SE, Mizgerd JP, Doerschuk CM. Very late antigen-4 in CD18-independent neutrophil emigration during acute bacterial pneumonia in mice. Am J Respir Crit Care Med. 2002 Jul 1; 166(1):53-60. PMID: 12091171.
Mizgerd JP. Molecular mechanisms of neutrophil recruitment elicited by bacteria in the lungs. Semin Immunol. 2002 Apr; 14(2):123-32. PMID: 11978084.
Alcamo E, Mizgerd JP, Horwitz BH, Bronson R, Beg AA, Scott M, Doerschuk CM, Hynes RO, Baltimore D. Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol. 2001 Aug 1; 167(3):1592-600. PMID: 11466381.
Huang C, De Sanctis GT, O'Brien PJ, Mizgerd JP, Friend DS, Drazen JM, Brass LF, Stevens RL. Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung. J Biol Chem. 2001 Jul 13; 276(28):26276-84.View Related Profiles.
Drazen, Jeffrey
Mizgerd, Joseph
PMID: 11335723.
Horwitz BH, Mizgerd JP, Scott ML, Doerschuk CM. Mechanisms of granulocytosis in the absence of CD18. Blood. 2001 Mar 15; 97(6):1578-83. PMID: 11238094.
Mizgerd JP, Spieker MR, Doerschuk CM. Early response cytokines and innate immunity: essential roles for TNF receptor 1 and type I IL-1 receptor during Escherichia coli pneumonia in mice. J Immunol. 2001 Mar 15; 166(6):4042-8. PMID: 11238652.
Mizgerd JP, Peschon JJ, Doerschuk CM. Roles of tumor necrosis factor receptor signaling during murine Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 2000 Jan; 22(1):85-91. PMID: 10615069.
Palombo JD, DeMichele SJ, Boyce PJ, Lydon EE, Liu JW, Huang YS, Forse RA, Mizgerd JP, Bistrian BR. Effect of short-term enteral feeding with eicosapentaenoic and gamma-linolenic acids on alveolar macrophage eicosanoid synthesis and bactericidal function in rats. Crit Care Med. 1999 Sep; 27(9):1908-15. PMID: 10507617.
Mizgerd JP, Horwitz BH, Quillen HC, Scott ML, Doerschuk CM. Effects of CD18 deficiency on the emigration of murine neutrophils during pneumonia. J Immunol. 1999 Jul 15; 163(2):995-9. PMID: 10395697.
Doerschuk CM, Mizgerd JP, Kubo H, Qin L, Kumasaka T. Adhesion molecules and cellular biomechanical changes in acute lung injury: Giles F. Filley Lecture. Chest. 1999 Jul; 116(1 Suppl):37S-43S. PMID: 10424587.
Mizgerd JP, Bullard DC, Hicks MJ, Beaudet AL, Doerschuk CM. Chronic inflammatory disease alters adhesion molecule requirements for acute neutrophil emigration in mouse skin. J Immunol. 1999 May 1; 162(9):5444-8. PMID: 10228023.
Mizgerd JP, Quinlan WM, LeBlanc BW, Kutkoski GJ, Bullard DC, Beaudet AL, Doerschuk CM. Combinatorial requirements for adhesion molecules in mediating neutrophil emigration during bacterial peritonitis in mice. J Leukoc Biol. 1998 Sep; 64(3):291-7. PMID: 9738654.
Mizgerd JP, Horwitz BH, Bhagwan SD, Scott ML, Beaudet AL, Doerschuk CM. Compromised emigration of CD18-deficient neutrophils during LPS pneumonia in bone marrow chimera mice. 1998.
Bran JD, Molina RM, Mizgerd JP, Warner AE. Mechanism of gadolinium-induced macrophage inactivation. 1998.
Mizgerd JP, Kubo H, Kutkoski GJ, Bhagwan SD, Scharffetter-Kochanek K, Beaudet AL, Doerschuk CM. Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice. J Exp Med. 1997 Oct 20; 186(8):1357-64. PMID: 9334375; PMCID: PMC2199087.
Mizgerd JP, Meek BB, Kutkoski GJ, Bullard DC, Beaudet AL, Doerschuk CM. Selectins and neutrophil traffic: margination and Streptococcus pneumoniae-induced emigration in murine lungs. J Exp Med. 1996 Aug 1; 184(2):639-45. PMID: 8760817; PMCID: PMC2192708.
Mizgerd JP, Molina RM, Stearns RC, Brain JD, Warner AE. Gadolinium induces macrophage apoptosis. J Leukoc Biol. 1996 Feb; 59(2):189-95. PMID: 8603991.
Mizgerd JP, Kobzik L, Warner AE, Brain JD. Effects of sodium concentration on human neutrophil bactericidal functions. Am J Physiol. 1995 Sep; 269(3 Pt 1):L388-93. PMID: 7573473.
Mizgerd JP, Brain JD. Reactive oxygen species in the killing of Pseudomonas aeruginosa by human leukocytes. Curr Microbiol. 1995 Aug; 31(2):124-8. PMID: 7606187.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 110 publications over 24 distinct years, with a maximum of 14 publications in 2012