Yonghui Jia | Profiles RNS

Yonghui Jia, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

General Internal Medicine

Websites

Dr. Yonghui Jia studies molecular genetics and molecular immunology. She has worked at the VA Central Biorepository since 2022, which processes biospecimens for downstream applications. Before coming to BU, she worked at private genetics companies and at the Center for Advanced Molecular Diagnostics at Brigham and Women's Hospital. Her extensive array of research includes significant work in cancer genomics.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Hanna GJ, Villa A, Mistry N, Jia Y, Quinn CT, Turner MM, Felt KD, Pfaff K, Haddad RI, Uppaluri R, Rodig SJ, Woo SB, Egloff AM, Hodi FS. Correction: Comprehensive Immunoprofiling of High-risk Oral Proliferative and Localized Leukoplakia. Cancer Res Commun. 2022 May; 2(5):390. PMID: 36875716; PMCID: PMC9981205; DOI: 10.1158/2767-9764.CRC-22-0193;

Li YY, Schmidt RJ, Manning DK, Jia Y, Dong F. Contamination Assessment for Cancer Next-Generation Sequencing. Arch Pathol Lab Med. 2022 Jan 02; 146(2):227-232. PMID: 34015814; DOI: 10.5858/arpa.2020-0679-OA;

Hanna GJ, Villa A, Mistry N, Jia Y, Quinn CT, Turner MM, Felt KD, Pfaff K, Haddad RI, Uppaluri R, Rodig SJ, Woo SB, Egloff AM, Hodi FS. Comprehensive Immunoprofiling of High-Risk Oral Proliferative and Localized Leukoplakia. Cancer Res Commun. 2021 Oct; 1(1):30-40. PMID: 36860910; PMCID: PMC9973379; DOI: 10.1158/2767-9764.CRC-21-0060;

Hou Q, Liu F, Chakraborty A, Jia Y, Prasad A, Yu H, Zhao L, Ye K, Snyder SH, Xu Y, Luo HR. Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia. Sci Transl Med. 2018 Apr 04; 10(435). PMID: 29618559; PMCID: PMC6435359; DOI: 10.1126/scitranslmed.aal4045;

Garcia EP, Minkovsky A, Jia Y, Ducar MD, Shivdasani P, Gong X, Ligon AH, Sholl LM, Kuo FC, MacConaill LE, Lindeman NI, Dong F. Validation of OncoPanel: A Targeted Next-Generation Sequencing Assay for the Detection of Somatic Variants in Cancer. Arch Pathol Lab Med. 2017 Jun; 141(6):751-758. PMID: 28557599; DOI: 10.5858/arpa.2016-0527-OA;

Sholl LM, Do K, Shivdasani P, Cerami E, Dubuc AM, Kuo FC, Garcia EP, Jia Y, Davineni P, Abo RP, Pugh TJ, van Hummelen P, Thorner AR, Ducar M, Berger AH, Nishino M, Janeway KA, Church A, Harris M, Ritterhouse LL, Campbell JD, Rojas-Rudilla V, Ligon AH, Ramkissoon S, Cleary JM, Matulonis U, Oxnard GR, Chao R, Tassell V, Christensen J, Hahn WC, Kantoff PW, Kwiatkowski DJ, Johnson BE, Meyerson M, Garraway LA, Shapiro GI, Rollins BJ, Lindeman NI, MacConaill LE. Institutional implementation of clinical tumor profiling on an unselected cancer population. JCI Insight. 2016 11 17; 1(19):e87062.View Related Profiles.

Oxnard, Geoffrey
Campbell, Joshua
Jia, Yonghui

PMID: 27882345; PMCID: PMC5111542; DOI: 10.1172/jci.insight.87062;

Mason EF, Brown RD, Szeto DP, Gibson CJ, Jia Y, Garcia EP, Jacobson CA, Dal Cin P, Kuo FC, Pinkus GS, Lindeman NI, Sholl LM, Aster JC, Morgan EA. Detection of activating MAP2K1 mutations in atypical hairy cell leukemia and hairy cell leukemia variant. Leuk Lymphoma. 2017 Jan; 58(1):233-236. PMID: 27241017; DOI: 10.1080/10428194.2016.1185786;

Ritterhouse LL, Nowak JA, Strickland KC, Garcia EP, Jia Y, Lindeman NI, Macconaill LE, Konstantinopoulos PA, Matulonis UA, Liu J, Berkowitz RS, Nucci MR, Crum CP, Sholl LM, Howitt BE. Morphologic correlates of molecular alterations in extrauterine Müllerian carcinomas. Mod Pathol. 2016 Aug; 29(8):893-903. PMID: 27150160; DOI: 10.1038/modpathol.2016.82;

Stachler M, Jia Y, Sharaf N, Wade J, Longtine J, Garcia E, Sholl LM. Filter Paper-based Nucleic Acid Storage in High-throughput Solid Tumor Genotyping. Appl Immunohistochem Mol Morphol. 2015; 23(5):389-96. PMID: 25221956; DOI: 10.1097/PAI.0000000000000086;

Liu J, Jia Y, Li J, Chu Z. Transcriptional profiling analysis of individual kinase-deletion strains of fission yeast in response to nitrogen starvation. Mol Genet Genomics. 2015 Jun; 290(3):1067-83. PMID: 25528445; DOI: 10.1007/s00438-014-0966-6;

Showing 10 of 36 results. Show More

Lian CG, Sholl LM, Zakka LR, O TM, Liu C, Xu S, Stanek E, Garcia E, Jia Y, MacConaill LE, Murphy GF, Waner M, Mihm MC. Novel genetic mutations in a sporadic port-wine stain. JAMA Dermatol. 2014 Dec; 150(12):1336-40. PMID: 25188413; DOI: 10.1001/jamadermatol.2014.1244;

Howitt BE, Sholl LM, Dal Cin P, Jia Y, Yuan L, MacConaill L, Lindeman N, Kuo F, Garcia E, Nucci MR, Quade BJ. Targeted genomic analysis of Müllerian adenosarcoma. J Pathol. 2015 Jan; 235(1):37-49. PMID: 25231023; DOI: 10.1002/path.4442;

MacConaill LE, Garcia E, Shivdasani P, Ducar M, Adusumilli R, Breneiser M, Byrne M, Chung L, Conneely J, Crosby L, Garraway LA, Gong X, Hahn WC, Hatton C, Kantoff PW, Kluk M, Kuo F, Jia Y, Joshi R, Longtine J, Manning A, Palescandolo E, Sharaf N, Sholl L, van Hummelen P, Wade J, Wollinson BM, Zepf D, Rollins BJ, Lindeman NI. Prospective enterprise-level molecular genotyping of a cohort of cancer patients. J Mol Diagn. 2014 Nov; 16(6):660-72. PMID: 25157968; PMCID: PMC4210463; DOI: 10.1016/j.jmoldx.2014.06.004;

Stygelbout V, Leroy K, Pouillon V, Ando K, D'Amico E, Jia Y, Luo HR, Duyckaerts C, Erneux C, Schurmans S, Brion JP. Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology. Brain. 2014 Feb; 137(Pt 2):537-52. PMID: 24401760; DOI: 10.1093/brain/awt344;

Howitt BE, Jia Y, Sholl LM, Barletta JA. Molecular alterations in partially-encapsulated or well-circumscribed follicular variant of papillary thyroid carcinoma. Thyroid. 2013 Oct; 23(10):1256-62. PMID: 23477374; DOI: 10.1089/thy.2013.0018;

Sakai J, Li J, Subramanian KK, Mondal S, Bajrami B, Hattori H, Jia Y, Dickinson BC, Zhong J, Ye K, Chang CJ, Ho YS, Zhou J, Luo HR. Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils. Immunity. 2012 Dec 14; 37(6):1037-49. PMID: 23159440; PMCID: PMC3525814; DOI: 10.1016/j.immuni.2012.08.017;

Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci. 2012 Mar 04; 15(4):565-73. PMID: 22388960; DOI: 10.1038/nn.3059;

Mondal S, Ghosh-Roy S, Loison F, Li Y, Jia Y, Harris C, Williams DA, Luo HR. PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase. J Immunol. 2011 Dec 01; 187(11):5783-94. PMID: 22043008; PMCID: PMC3221816; DOI: 10.4049/jimmunol.1100484;

He K, Chan CB, Liu X, Jia Y, Luo HR, France SA, Liu Y, Wilson WD, Ye K. Identification of a molecular activator for insulin receptor with potent anti-diabetic effects. J Biol Chem. 2011 Oct 28; 286(43):37379-88. PMID: 21908618; PMCID: PMC3199485; DOI: 10.1074/jbc.M111.247387;

Prasad A, Jia Y, Chakraborty A, Li Y, Jain SK, Zhong J, Roy SG, Loison F, Mondal S, Sakai J, Blanchard C, Snyder SH, Luo HR. Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Nat Immunol. 2011 Jun 19; 12(8):752-60. PMID: 21685907; PMCID: PMC3140608; DOI: 10.1038/ni.2052;

Li Y, Prasad A, Jia Y, Roy SG, Loison F, Mondal S, Kocjan P, Silberstein LE, Ding S, Luo HR. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16; 117(24):6702-13. PMID: 21521784; PMCID: PMC3123029; DOI: 10.1182/blood-2010-09-309864;

Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K. A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. J Med Chem. 2010 Dec 09; 53(23):8274-86. PMID: 21073191; PMCID: PMC3150605; DOI: 10.1021/jm101206p;

Hattori H, Subramanian KK, Sakai J, Jia Y, Li Y, Porter TF, Loison F, Sarraj B, Kasorn A, Jo H, Blanchard C, Zirkle D, McDonald D, Pai SY, Serhan CN, Luo HR. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3546-51. PMID: 20142487; PMCID: PMC2840460; DOI: 10.1073/pnas.0914351107;

Kasorn A, Alcaide P, Jia Y, Subramanian KK, Sarraj B, Li Y, Loison F, Hattori H, Silberstein LE, Luscinskas WF, Luo HR. Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol. 2009 Jul 15; 183(2):1032-43. PMID: 19561112; PMCID: PMC4388231; DOI: 10.4049/jimmunol.0802984;

Li Y, Jia Y, Pichavant M, Loison F, Sarraj B, Kasorn A, You J, Robson BE, Umetsu DT, Mizgerd JP, Ye K, Luo HR. Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood. 2009 May 14; 113(20):4930-41.View Related Profiles.

Mizgerd, Joseph
Jia, Yonghui

PMID: 19286998; PMCID: PMC2686143; DOI: 10.1182/blood-2008-06-161414;

Jia Y, Schurmans S, Luo HR. Regulation of innate immunity by inositol 1,3,4,5-tetrakisphosphate. Cell Cycle. 2008 Sep 15; 7(18):2803-8. PMID: 18769148; DOI: 10.4161/cc.7.18.6688;

Jo H, Jia Y, Subramanian KK, Hattori H, Luo HR. Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation. Mol Cell Biol. 2008 Jul; 28(13):4285-99. PMID: 18458059; PMCID: PMC2447147; DOI: 10.1128/MCB.01240-07;

Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4739-44. PMID: 18339802; PMCID: PMC2290809; DOI: 10.1073/pnas.0800218105;

Jia Y, Subramanian KK, Erneux C, Pouillon V, Hattori H, Jo H, You J, Zhu D, Schurmans S, Luo HR. Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils. Immunity. 2007 Sep; 27(3):453-67. PMID: 17825589; PMCID: PMC2084373; DOI: 10.1016/j.immuni.2007.07.016;

Maréchal Y, Pesesse X, Jia Y, Pouillon V, Pérez-Morga D, Daniel J, Izui S, Cullen PJ, Leo O, Luo HR, Erneux C, Schurmans S. Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13978-83. PMID: 17709751; PMCID: PMC1955816; DOI: 10.1073/pnas.0704312104;

Hattori H, Zhang X, Jia Y, Subramanian KK, Jo H, Loison F, Newburger PE, Luo HR. RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Blood. 2007 Jul 15; 110(2):640-50. PMID: 17420285; PMCID: PMC1924478; DOI: 10.1182/blood-2006-11-059048;

Subramanian KK, Jia Y, Zhu D, Simms BT, Jo H, Hattori H, You J, Mizgerd JP, Luo HR. Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood. 2007 May 1; 109(9):4028-37.View Related Profiles.

Mizgerd, Joseph
Jia, Yonghui

PMID: 17202315; PMCID: PMC1874585; DOI: 10.1182/blood-2006-10-055319;

Zhu D, Hattori H, Jo H, Jia Y, Subramanian KK, Loison F, You J, Le Y, Honczarenko M, Silberstein L, Luo HR. Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14836-41. PMID: 16988010; PMCID: PMC1595438; DOI: 10.1073/pnas.0605722103;

Bimbó A, Jia Y, Poh SL, Karuturi RK, den Elzen N, Peng X, Zheng L, O'Connell M, Liu ET, Balasubramanian MK, Liu J. Systematic deletion analysis of fission yeast protein kinases. Eukaryot Cell. 2005 Apr; 4(4):799-813. PMID: 15821139; PMCID: PMC1087820; DOI: 10.1128/EC.4.4.799-813.2005;

Peng X, Karuturi RK, Miller LD, Lin K, Jia Y, Kondu P, Wang L, Wong LS, Liu ET, Balasubramanian MK, Liu J. Identification of cell cycle-regulated genes in fission yeast. Mol Biol Cell. 2005 Mar; 16(3):1026-42. PMID: 15616197; PMCID: PMC551471; DOI: 10.1091/mbc.e04-04-0299;

Li L, Jia Y, Hou Q, Charles TC, Nester EW, Pan SQ. A global pH sensor: Agrobacterium sensor protein ChvG regulates acid-inducible genes on its two chromosomes and Ti plasmid. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12369-74. PMID: 12218184; PMCID: PMC129451; DOI: 10.1073/pnas.192439499;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 36 publications over 18 distinct years, with a maximum of 5 publications in 2014

Bar chart showing 36 publications over 18 distinct years, with a maximum of 5 publications in 2014

Year	Publications
2002	1
2004	1
2005	1
2006	1
2007	4
2008	3
2009	2
2010	2
2011	4
2012	2
2013	1
2014	5
2015	1
2016	3
2017	1
2018	1
2021	1
2022	2

2016 Brigham and Women’s Hospital, Harvard Medical School: Partners in Excellence TEAM AWARD

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