Igor Kramnik | Profiles RNS

Igor Kramnik, MD, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Samara State Medical University
PhD, Russian Academy of Medical Sciences

Websites

	Microbiology Faculty
	Immunology Training Program Faculty
	National Emerging Infectious Diseases Laboratories Faculty

ORCID : 0000-0001-6511-9246

Control of tuberculosis (TB) remains a global health priority despite a significant decrease in its prevalence within the past century. New challenges have emerged with the appearance of drug resistant forms of M.tb and the realization that the existing BCG vaccine is not sufficiently effective to eradicate the disease. Thus, the emergence and spread of drug resistant forms of Mycobacterium tuberculosis (M.tb) represents a significant global threat of re-emerging epidemics of TB with no effective therapies in sight.. Given the dearth of new drugs targeting the pathogen, interventions targeting host cells are urgently needed. However, our limited understanding of the virulence stragegy of M.tb remains a major obstacle to its complete eradication. In our view two major gaps exist on the host side: what makes some immunocompetent individuals more susceptible to M.tb than the majority of the population, and what makes the lungs an organ that is particularly vulnerable to M.tb. The lung is central to the virulence strategy of M.tb, because aerosol is the only epidemiologically significant route of M.tb transmission in human populations. Interventions that target the lung to enhance mechanisms of local immunity and prevent lung damage may produce the biggest epidemiological impact by preventing M.tb transmission.

We pursue identification of pathways exploited by the pathogen in the lungs of susceptible individuals – a critical node in the extremely successful evolutionary strategy of M.tb - and the development of targeted interventions. Our lab and collaborators described a novel mouse model of human-like pulmonary tuberculosis. The key element of this model is the development of well organized necrotic granulomas, which closely resemble the human disease, specifically in the lungs of otherwise immunocompetent mice. Using forward genetic analysis we identifed the sst1 locus as the one responsible for necrotization of the lung granulomas and identified the candidate gene Ipr1 using positional cloning. We have found that the Ipr1 protein is an interferon-inducible chromatin-associated protein involved in control of macrophage activation and death. Our current efforts are focused on understanding the Ipr1-mediated biochemical pathways and their role in host resistance to infections, control of lung inflammation and tissue damage. In addition we have developed a screening strategy to identify compounds that enhance the Ipr1 function, which can be developed into novel drugs that increase host resistance to M.tuberculosis and related infections.

During the course of these studies we documented the development of lung squamous cell carcinomas (SSC) at the chronic stages of tuberculosis infection. Because squamous cell carcinomas do not occur in our mouse strains spontaneously, we concluded that M.tb infection was sufficient for both initiation and progression of lung SCC. These findings experimentally proved a causal link between tuberculosis and lung cancers, recently confirmed by epidemiological analysis in humans. Thus the TB-infected lung presents a destabilizing environment for epithelial cells, yet factors influencing epithelial cell function in the context of chronic infection have not been much studied. We study lung epithelial cells over the course of TB infection to understand mechanisms of their injury, repair, and neoplastic transformation in order to develop interventions that restore epithelial cell homeostasis and prevent initiation of lung tumors during TB progression.

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology

Faculty
Boston University
National Emerging Infectious Disease Lab

Member
Boston University
Pulmonary Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Boston Medical Center

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Toxin secretion and trafficking by Mycobacterium tuberculosis
07/17/2023 - 06/30/2027 (Subcontract PI)
University of Alabama at Birmingham NIH NIAID
1R01AI175106-01

Necrosis in Pulmonary TB granulomas: dynamics, mechanisms, and therapies
03/04/2022 - 02/28/2026 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL126066-07

Sideropher-depedent inhibitors of Mycobacterium tuberculosis
06/22/2020 - 05/31/2022 (Subcontract PI)
University of Alabama at Birmingham NIH NIAID
5R21AI153981-02

Aberrant Immune activation in the tuberculous granuloma: a pivotal role in necrosis
07/15/2016 - 06/30/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL133190-04

Necrosis in Pulmonary TB granulomas: dynamics, mechanisms, therapies
05/01/2016 - 04/30/2021 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL126066-04

Novel TB Treatment Strategy - Optimization of Macrophage Responsiveness to IFNy
03/11/2015 - 02/28/2019 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R33AI105944-05

Genetic-based susceptibility to pulmonary tuberculosis
04/15/2015 - 03/31/2018 (Subcontract PI)
Trustees of Tufts College, Inc NIH NIAID
5R21AI115038-02

Novel TB Treatment Strategy- Optimization of Macrophage Responsiveness to IFNy
03/01/2013 - 02/28/2015 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI105944-02

Genetics of Host Resistance and Susceptibility to MTB
08/01/2012 - 07/31/2014 (PI)
NIH/National Heart, Lung, and Blood Institute
7R01HL059836-16

National Emerging Infectious Diseases Laboratories Operations
06/20/2012 - 07/31/2014 (Sub-Project Level Key Person)
PI: John R. Murphy, PhD
NIH/National Institute of Allergy & Infectious Diseases
3UC7AI070088-05S3

Showing 10 of 12 results. Show All Results

Genetics of Host resistance & susceptibility to MTB
08/01/2009 - 08/02/2012 (PI)
NIH-NHLBI
5R01 HL059836-15

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Necrosis in Pulmonary TB granulomas: dynamics, mechanisms, and therapies	5R01HL126066-07
2023	Necrosis in Pulmonary TB granulomas: dynamics, mechanisms, and therapies	5R01HL126066-06
2022	Necrosis in Pulmonary TB granulomas: dynamics, mechanisms, and therapies	2R01HL126066-05
2019	Aberrant immune activation in the tuberculosis granuloma: a pivotal role in necrosis	5R01HL133190-04	4
2019	Necrosis in pulmonary TB granulomas: dynamics, mechanisms, therapies	5R01HL126066-04	5
2018	Aberrant immune activation in the tuberculosis granuloma: a pivotal role in necrosis	5R01HL133190-03	4
2018	Necrosis in pulmonary TB granulomas: dynamics, mechanisms, therapies	5R01HL126066-03	5
2017	Aberrant immune activation in the tuberculosis granuloma: a pivotal role in necrosis	5R01HL133190-02	4
2017	Necrosis in pulmonary TB granulomas: dynamics, mechanisms, therapies	5R01HL126066-02	5
2017	Novel TB Treatment Strategy - Optimization of Macrophage Responsiveness to IFNy	5R33AI105944-05	4

Showing 10 of 35 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Koyuncu D, Tavolara T, Gatti DM, Gower AC, Ginese ML, Kramnik I, Yener B, Sajjad U, Niazi MKK, Gurcan M, Alsharaydeh A, Beamer G. B cells in perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell signatures identify asymptomatic Mycobacterium tuberculosis lung infection in Diversity Outbred mice. Infect Immun. 2024 Jul 11; 92(7):e0026323.View Related Profiles.

Gower, Adam
Kramnik, Igor

PMID: 38899881; PMCID: PMC11238564; DOI: 10.1128/iai.00263-23;

Gatti DM, Tyler AL, Mahoney JM, Churchill GA, Yener B, Koyuncu D, Gurcan MN, Niazi MK, Tavolara T, Gower A, Dayao D, McGlone E, Ginese ML, Specht A, Alsharaydeh A, Tessier PA, Kurtz SL, Elkins KL, Kramnik I, Beamer G. Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice. PLoS Pathog. 2024 Jun; 20(6):e1011915.View Related Profiles.

Gower, Adam
Kramnik, Igor

PMID: 38861581; PMCID: PMC11195971; DOI: 10.1371/journal.ppat.1011915;

Dartois V, Bonfield TL, Boyce JP, Daley CL, Dick T, Gonzalez-Juarrero M, Gupta S, Kramnik I, Lamichhane G, Laughon BE, Lorè NI, Malcolm KC, Olivier KN, Tuggle KL, Jackson M. Preclinical murine models for the testing of antimicrobials against Mycobacterium abscessus pulmonary infections: Current practices and recommendations. Tuberculosis (Edinb). 2024 Jul; 147:102503. PMID: 38729070; PMCID: PMC11168888; DOI: 10.1016/j.tube.2024.102503;

Yabaji SM, Zhernovkov V, Araveti PB, Lata S, Rukhlenko OS, Abdullatif SA, Alekseev Y, Ma Q, Dayama G, Lau NC, Bishai WR, Crossland NA, Campbell JD, Kholodenko BN, Gimelbrant AA, Kobzik L, Kramnik I. Myc Dysregulation in Activated Macrophages Initiates Iron-Mediated Lipid Peroxidation that Fuels Type I Interferon and Compromises TB Resistance. bioRxiv. 2024 Mar 10.View Related Profiles.

VanValkenburg, Arthur
Kramnik, Igor
Lau, Nelson
Crossland, Nicholas
Araveti, Prasanna
Yabaji, Shivraj
Lata, Suruchi

PMID: 38496444; PMCID: PMC10942339; DOI: 10.1101/2024.03.05.583602;

Amaral EP, Namasivayam S, Queiroz ATL, Fukutani E, Hilligan KL, Aberman K, Fisher L, Bomfim CCB, Kauffman K, Buchanan J, Santuo L, Gazzinelli-Guimaraes PH, Costa DL, Teixeira MA, Barreto-Duarte B, Rocha CG, Santana MF, Cordeiro-Santos M, Barber DL, Wilkinson RJ, Kramnik I, Igarashi K, Scriba T, Mayer-Barber KD, Andrade BB, Sher A. BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility. Nat Microbiol. 2024 Jan; 9(1):120-135. PMID: 38066332; PMCID: PMC10769877; DOI: 10.1038/s41564-023-01523-7;

Yabaji SM, Rukhlenko OS, Chatterjee S, Bhattacharya B, Wood E, Kasaikina M, Kholodenko BN, Gimelbrant AA, Kramnik I. Cell state transition analysis identifies interventions that improve control of Mycobacterium tuberculosis infection by susceptible macrophages. Sci Adv. 2023 Sep 29; 9(39):eadh4119.View Related Profiles.

Bhattacharya, Bidisha
Kramnik, Igor
Yabaji, Shivraj

PMID: 37756395; PMCID: PMC10530096; DOI: 10.1126/sciadv.adh4119;

Klever AM, Alexander KA, Almeida D, Anderson MZ, Ball RL, Beamer G, Boggiatto P, Buikstra JE, Chandler B, Claeys TA, Concha AE, Converse PJ, Derbyshire KM, Dobos KM, Dupnik KM, Endsley JJ, Endsley MA, Fennelly K, Franco-Paredes C, Hagge DA, Hall-Stoodley L, Hayes D, Hirschfeld K, Hofman CA, Honda JR, Hull NM, Kramnik I, Lacourciere K, Lahiri R, Lamont EA, Larsen MH, Lemaire T, Lesellier S, Lee NR, Lowry CA, Mahfooz NS, McMichael TM, Merling MR, Miller MA, Nagajyothi JF, Nelson E, Nuermberger EL, Pena MT, Perea C, Podell BK, Pyle CJ, Quinn FD, Rajaram MVS, Mejia OR, Rothoff M, Sago SA, Salvador LCM, Simonson AW, Spencer JS, Sreevatsan S, Subbian S, Sunstrum J, Tobin DM, Vijayan KKV, Wright CTO, Robinson RT. The Many Hosts of Mycobacteria 9 (MHM9): A conference report. Tuberculosis (Edinb). 2023 Sep; 142:102377. PMID: 37531864; PMCID: PMC10529179; DOI: 10.1016/j.tube.2023.102377;

Krug S, Prasad P, Xiao S, Lun S, Ruiz-Bedoya CA, Klunk M, Ordonez AA, Jain SK, Srikrishna G, Kramnik I, Bishai WR. Adjunctive Integrated Stress Response Inhibition Accelerates Tuberculosis Clearance in Mice. mBio. 2023 Apr 25; 14(2):e0349622. PMID: 36853048; PMCID: PMC10128048; DOI: 10.1128/mbio.03496-22;

Yabaji SM, Rukhlenko OS, Chatterjee S, Bhattacharya B, Wood E, Kasaikina M, Kholodenko B, Gimelbrant AA, Kramnik I. Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages. bioRxiv. 2023 Feb 10.View Related Profiles.

Bhattacharya, Bidisha
Kramnik, Igor
Yabaji, Shivraj

PMID: 36798271; PMCID: PMC9934610; DOI: 10.1101/2023.02.09.527908;

Rosenbloom R, Gavrish I, Tseng AE, Seidel K, Yabaji SM, Gertje HP, Huber BR, Kramnik I, Crossland NA. Progression and Dissemination of Pulmonary Mycobacterium Avium Infection in a Susceptible Immunocompetent Mouse Model. Int J Mol Sci. 2022 May 26; 23(11).View Related Profiles.

Huber, Bertrand
Kramnik, Igor
Seidel, Kerstin
Crossland, Nicholas
Yabaji, Shivraj

PMID: 35682679; PMCID: PMC9181083; DOI: 10.3390/ijms23115999;

Showing 10 of 69 results. Show More

Yabaji SM, Chatterjee S, Waligursky E, Gimelbrant A, Kramnik I. Medium throughput protocol for genome-based quantification of intracellular mycobacterial loads and macrophage survival during in vitro infection. STAR Protoc. 2022 06 17; 3(2):101241.View Related Profiles.

Kramnik, Igor
Yabaji, Shivraj

PMID: 35310069; PMCID: PMC8931439; DOI: 10.1016/j.xpro.2022.101241;

Koyuncu D, Niazi MKK, Tavolara T, Abeijon C, Ginese ML, Liao Y, Mark C, Specht A, Gower AC, Restrepo BI, Gatti DM, Kramnik I, Gurcan M, Yener B, Beamer G. CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice. PLoS Pathog. 2021 08; 17(8):e1009773.View Related Profiles.

Gower, Adam
Kramnik, Igor

PMID: 34403447; PMCID: PMC8423361; DOI: 10.1371/journal.ppat.1009773;

Chatterjee S, Yabaji SM, Rukhlenko OS, Bhattacharya B, Waligurski E, Vallavoju N, Ray S, Kholodenko BN, Brown LE, Beeler AB, Ivanov AR, Kobzik L, Porco JA, Kramnik I. Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis. iScience. 2021 Aug 20; 24(8):102845.View Related Profiles.

Beeler, Aaron
Bhattacharya, Bidisha
Kramnik, Igor
Porco, John
Brown, Lauren
Yabaji, Shivraj

PMID: 34381970; PMCID: PMC8333345; DOI: 10.1016/j.isci.2021.102845;

Ji DX, Witt KC, Kotov DI, Margolis SR, Louie A, Chevée V, Chen KJ, Gaidt MM, Dhaliwal HS, Lee AY, Nishimura SL, Zamboni DS, Kramnik I, Portnoy DA, Darwin KH, Vance RE. Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons. Elife. 2021 06 21; 10. PMID: 34151776; PMCID: PMC8248984; DOI: 10.7554/eLife.67290;

Ordonez AA, Tucker EW, Anderson CJ, Carter CL, Ganatra S, Kaushal D, Kramnik I, Lin PL, Madigan CA, Mendez S, Rao J, Savic RM, Tobin DM, Walzl G, Wilkinson RJ, Lacourciere KA, Via LE, Jain SK. Visualizing the dynamics of tuberculosis pathology using molecular imaging. J Clin Invest. 2021 03 01; 131(5). PMID: 33645551; PMCID: PMC7919721; DOI: 10.1172/JCI145107;

Bhattacharya B, Xiao S, Chatterjee S, Urbanowski M, Ordonez A, Ihms EA, Agrahari G, Lun S, Berland R, Pichugin A, Gao Y, Connor J, Ivanov AR, Yan BS, Kobzik L, Koo BB, Jain S, Bishai W, Kramnik I. The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas. J Clin Invest. 2021 02 01; 131(3).View Related Profiles.

Koo, Bang-bon
Bhattacharya, Bidisha
Kramnik, Igor
Connor, John

PMID: 33301427; PMCID: PMC7843230; DOI: 10.1172/JCI130319;

Apt AS, Kramnik I, McMurray DN. Editorial: Mycobacteria-Host Interactions: Genetics, Immunity, Pathology. Front Cell Infect Microbiol. 2020; 10:611216. PMID: 33194847; PMCID: PMC7661744; DOI: 10.3389/fcimb.2020.611216;

Gregory DJ, DeLoid GM, Salmon SL, Metzger DW, Kramnik I, Kobzik L. SON DNA-binding protein mediates macrophage autophagy and responses to intracellular infection. FEBS Lett. 2020 09; 594(17):2782-2799. PMID: 32484234; PMCID: PMC7708400; DOI: 10.1002/1873-3468.13851;

Ji DX, Yamashiro LH, Chen KJ, Mukaida N, Kramnik I, Darwin KH, Vance RE. Publisher Correction: Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra. Nat Microbiol. 2020 05; 5(5):777. PMID: 32300234

Kurtz SL, Rossi AP, Beamer GL, Gatti DM, Kramnik I, Elkins KL. The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection. mSphere. 2020 04 15; 5(2). PMID: 32295871; PMCID: PMC7160682; DOI: 10.1128/mSphere.00097-20;

Ji DX, Yamashiro LH, Chen KJ, Mukaida N, Kramnik I, Darwin KH, Vance RE. Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra. Nat Microbiol. 2019 12; 4(12):2128-2135. PMID: 31611644; PMCID: PMC6879852; DOI: 10.1038/s41564-019-0578-3;

Carow B, Hauling T, Qian X, Kramnik I, Nilsson M, Rottenberg ME. Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma. Nat Commun. 2019 04 23; 10(1):1823. PMID: 31015452; PMCID: PMC6479067; DOI: 10.1038/s41467-019-09816-4;

Gregory DJ, Kramnik I, Kobzik L. Protection of macrophages from intracellular pathogens by miR-182-5p mimic-a gene expression meta-analysis approach. FEBS J. 2018 01; 285(2):244-260. PMID: 29197182; PMCID: PMC5845812; DOI: 10.1111/febs.14348;

Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP. Capacity of Pneumococci to Activate Macrophage Nuclear Factor ?B: Influence on Necroptosis and Pneumonia Severity. J Infect Dis. 2017 Aug 15; 216(4):425-435.View Related Profiles.

Wilson, Andrew
Kotton, Darrell
Coleman, Fadie
Kramnik, Igor
Mizgerd, Joseph
Yamamoto, Kazuko
Quinton, Lee
Jones, Matthew
Pelton, Stephen

PMID: 28368460; PMCID: PMC6279164; DOI: 10.1093/infdis/jix159;

Leu JS, Chen ML, Chang SY, Yu SL, Lin CW, Wang H, Chen WC, Chang CH, Wang JY, Lee LN, Yu CJ, Kramnik I, Yan BS. SP110b Controls Host Immunity and Susceptibility to Tuberculosis. Am J Respir Crit Care Med. 2017 Feb 01; 195(3):369-382. PMID: 27858493; PMCID: PMC5328177; DOI: 10.1164/rccm.201601-0103OC;

Coppola M, van Meijgaarden KE, Franken KL, Commandeur S, Dolganov G, Kramnik I, Schoolnik GK, Comas I, Lund O, Prins C, van den Eeden SJ, Korsvold GE, Oftung F, Geluk A, Ottenhoff TH. New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles. Sci Rep. 2016 11 28; 6:37793. PMID: 27892960; PMCID: PMC5125271; DOI: 10.1038/srep37793;

Bhattacharya B, Chatterjee S, Devine WG, Kobzik L, Beeler AB, Porco JA, Kramnik I. Fine-tuning of macrophage activation using synthetic rocaglate derivatives. Sci Rep. 2016 Apr 18; 6:24409.View Related Profiles.

Beeler, Aaron
Bhattacharya, Bidisha
Kramnik, Igor
Porco, John

PMID: 27086720; PMCID: PMC4834551; DOI: 10.1038/srep24409;

Kramnik I, Beamer G. Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies. Semin Immunopathol. 2016 Mar; 38(2):221-37. PMID: 26542392; PMCID: PMC4779126; DOI: 10.1007/s00281-015-0538-9;

Niazi MK, Dhulekar N, Schmidt D, Major S, Cooper R, Abeijon C, Gatti DM, Kramnik I, Yener B, Gurcan M, Beamer G. Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice. Dis Model Mech. 2015 Sep; 8(9):1141-53. PMID: 26204894; PMCID: PMC4582107; DOI: 10.1242/dmm.020867;

Irwin SM, Gruppo V, Brooks E, Gilliland J, Scherman M, Reichlen MJ, Leistikow R, Kramnik I, Nuermberger EL, Voskuil MI, Lenaerts AJ. Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas. Antimicrob Agents Chemother. 2014 Jul; 58(7):4026-34. PMID: 24798275; PMCID: PMC4068578; DOI: 10.1128/AAC.02565-14;

He X, Berland R, Mekasha S, Christensen TG, Alroy J, Kramnik I, Ingalls RR. The sst1 resistance locus regulates evasion of type I interferon signaling by Chlamydia pneumoniae as a disease tolerance mechanism. PLoS Pathog. 2013; 9(8):e1003569.View Related Profiles.

Kramnik, Igor
Ingalls, Robin
Christensen, Thomas
He, Xianbao

PMID: 24009502; PMCID: PMC3757055; DOI: 10.1371/journal.ppat.1003569;

Commandeur S, van Meijgaarden KE, Prins C, Pichugin AV, Dijkman K, van den Eeden SJ, Friggen AH, Franken KL, Dolganov G, Kramnik I, Schoolnik GK, Oftung F, Korsvold GE, Geluk A, Ottenhoff TH. An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection. J Immunol. 2013 Feb 15; 190(4):1659-71. PMID: 23319735; DOI: 10.4049/jimmunol.1201593;

Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol. 2013 Feb; 14(2):179-85. PMID: 23263557; PMCID: PMC3838897; DOI: 10.1038/ni.2509;

Driver ER, Ryan GJ, Hoff DR, Irwin SM, Basaraba RJ, Kramnik I, Lenaerts AJ. Evaluation of a mouse model of necrotic granuloma formation using C3HeB/FeJ mice for testing of drugs against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2012 Jun; 56(6):3181-95. PMID: 22470120; PMCID: PMC3370740; DOI: 10.1128/AAC.00217-12;

Kramnik I. Genetic dissection of pulmonary tuberculosis: implications for drug and vaccine development. Nihon Hansenbyo Gakkai Zasshi. 2012 Apr; 81(1-2):13. PMID: 22586941

Yang CS, Rodgers M, Min CK, Lee JS, Kingeter L, Lee JY, Jong A, Kramnik I, Lin X, Jung JU. The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity. Cell Host Microbe. 2012 Mar 15; 11(3):277-89. PMID: 22423967; PMCID: PMC3615900; DOI: 10.1016/j.chom.2012.01.019;

Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU. Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation. Cell Host Microbe. 2012 Mar 15; 11(3):264-76. PMID: 22423966; PMCID: PMC3616771; DOI: 10.1016/j.chom.2012.01.018;

Zhou H, DeLoid G, Browning E, Gregory DJ, Tan F, Bedugnis AS, Imrich A, Koziel H, Kramnik I, Lu Q, Kobzik L. Genome-wide RNAi screen in IFN-?-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis. PLoS One. 2012; 7(2):e31752. PMID: 22359626; PMCID: PMC3281001; DOI: 10.1371/journal.pone.0031752;

Harper J, Skerry C, Davis SL, Tasneen R, Weir M, Kramnik I, Bishai WR, Pomper MG, Nuermberger EL, Jain SK. Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions. J Infect Dis. 2012 Feb 15; 205(4):595-602. PMID: 22198962; PMCID: PMC3266133; DOI: 10.1093/infdis/jir786;

Cai L, Pan H, Trzcinski K, Thompson CM, Wu Q, Kramnik I. MYBBP1A: a new Ipr1's binding protein in mice. Mol Biol Rep. 2010 Dec; 37(8):3863-8. PMID: 20221700; PMCID: PMC3084015; DOI: 10.1007/s11033-010-0042-1;

Aryee MJ, Gutiérrez-Pabello JA, Kramnik I, Maiti T, Quackenbush J. An improved empirical bayes approach to estimating differential gene expression in microarray time-course data: BETR (Bayesian Estimation of Temporal Regulation). BMC Bioinformatics. 2009; 10:409. PMID: 20003283; PMCID: PMC2801687; DOI: 10.1186/1471-2105-10-409;

Pichugin AV, Yan BS, Sloutsky A, Kobzik L, Kramnik I. Dominant role of the sst1 locus in pathogenesis of necrotizing lung granulomas during chronic tuberculosis infection and reactivation in genetically resistant hosts. Am J Pathol. 2009 Jun; 174(6):2190-201. PMID: 19443700; PMCID: PMC2684184; DOI: 10.2353/ajpath.2009.081075;

Apt A, Kramnik I. Man and mouse TB: contradictions and solutions. Tuberculosis (Edinb). 2009 May; 89(3):195-8. PMID: 19345146; PMCID: PMC2705810; DOI: 10.1016/j.tube.2009.02.002;

Nalbandian A, Yan BS, Pichugin A, Bronson RT, Kramnik I. Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control. Oncogene. 2009 Apr 30; 28(17):1928-38. PMID: 19330024; DOI: 10.1038/onc.2009.32;

Sissons J, Yan BS, Pichugin AV, Kirby A, Daly MJ, Kramnik I. Multigenic control of tuberculosis resistance: analysis of a QTL on mouse chromosome 7 and its synergism with sst1. Genes Immun. 2009 Jan; 10(1):37-46. PMID: 18784733; PMCID: PMC3060060; DOI: 10.1038/gene.2008.68;

Kumar A, Deshane JS, Crossman DK, Bolisetty S, Yan BS, Kramnik I, Agarwal A, Steyn AJ. Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon. J Biol Chem. 2008 Jun 27; 283(26):18032-9. PMID: 18400743; PMCID: PMC2440631; DOI: 10.1074/jbc.M802274200;

Schurr E, Kramnik I. Genetic control of host susceptibility to tuberculosis. In: Handbook of Tuberculosis: Immunology and Cell Biology. Kaufmann SHE, Britton WJ (Eds.). WILEY-VCH Verlag. Weinheim, Germany. 2008; 295-336.

Kramnik I. Genetic dissection of host resistance to Mycobacterium tuberculosis: the sst1 locus and the Ipr1 gene. Curr Top Microbiol Immunol. 2008; 321:123-48. PMID: 18727490

Yan BS, Pichugin AV, Jobe O, Helming L, Eruslanov EB, Gutiérrez-Pabello JA, Rojas M, Shebzukhov YV, Kobzik L, Kramnik I. Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guérin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity. J Immunol. 2007 Nov 15; 179(10):6919-32. PMID: 17982083

Pan H, Mostoslavsky G, Eruslanov E, Kotton DN, Kramnik I. Dual-promoter lentiviral system allows inducible expression of noxious proteins in macrophages. J Immunol Methods. 2008 Jan 1; 329(1-2):31-44.View Related Profiles.

Kotton, Darrell
Mostoslavsky, Gustavo
Kramnik, Igor

PMID: 17967462; PMCID: PMC2244810; DOI: 10.1016/j.jim.2007.09.009;

Tosh K, Campbell SJ, Fielding K, Sillah J, Bah B, Gustafson P, Manneh K, Lisse I, Sirugo G, Bennett S, Aaby P, McAdam KP, Bah-Sow O, Lienhardt C, Kramnik I, Hill AV. Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. Proc Natl Acad Sci U S A. 2006 Jul 5; 103(27):10364-8. PMID: 16803959; PMCID: PMC1502463; DOI: 10.1073/pnas.0603340103;

Yan BS, Kirby A, Shebzukhov YV, Daly MJ, Kramnik I. Genetic architecture of tuberculosis resistance in a mouse model of infection. Genes Immun. 2006 Apr; 7(3):201-10. PMID: 16452998

Sullivan BM, Jobe O, Lazarevic V, Vasquez K, Bronson R, Glimcher LH, Kramnik I. Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production. J Immunol. 2005 Oct 1; 175(7):4593-602. PMID: 16177104

Pan H, Yan BS, Rojas M, Shebzukhov YV, Zhou H, Kobzik L, Higgins DE, Daly MJ, Bloom BR, Kramnik I. Ipr1 gene mediates innate immunity to tuberculosis. Nature. 2005 Apr 7; 434(7034):767-72. PMID: 15815631; PMCID: PMC1388092; DOI: 10.1038/nature03419;

Boyartchuk V, Rojas M, Yan BS, Jobe O, Hurt N, Dorfman DM, Higgins DE, Dietrich WF, Kramnik I. The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice. J Immunol. 2004 Oct 15; 173(8):5112-20. PMID: 15470055

Kramnik I, Boyartchuk V. Immunity to intracellular pathogens as a complex genetic trait. Curr Opin Microbiol. 2002 Feb; 5(1):111-7. PMID: 11834379

Kramnik I, Dietrich WF, Demant P, Bloom BR. Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8560-5. PMID: 10890913; PMCID: PMC26987

Alland D, Kramnik I, Weisbrod TR, Otsubo L, Cerny R, Miller LP, Jacobs WR, Bloom BR. Identification of differentially expressed mRNA in prokaryotic organisms by customized amplification libraries (DECAL): the effect of isoniazid on gene expression in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13227-32. PMID: 9789070; PMCID: PMC23765

Kramnik I, Demant P, Bloom BB. Susceptibility to tuberculosis as a complex genetic trait: analysis using recombinant congenic strains of mice. Novartis Found Symp. 1998; 217:120-31; discussion 132-7. PMID: 9949805

Barrera LF, Kramnik I, Skamene E, Radzioch D. I-A beta gene expression regulation in macrophages derived from mice susceptible or resistant to infection with M. bovis BCG. Mol Immunol. 1997 Mar; 34(4):343-55. PMID: 9244347

Radzioch D, Kramnik I, Skamene E. Molecular mechanisms of natural resistance to mycobacterial infections. Circ Shock. 1994 Nov; 44(3):115-20. PMID: 7600634

Barrera LF, Kramnik I, Skamene E, Radzioch D. Nitrite production by macrophages derived from BCG-resistant and -susceptible congenic mouse strains in response to IFN-gamma and infection with BCG. Immunology. 1994 Jul; 82(3):457-64. PMID: 7959883; PMCID: PMC1414881

Kramnik I, Radzioch D, Skamene E. T-helper 1-like subset selection in Mycobacterium bovis bacillus Calmette-Guérin-infected resistant and susceptible mice. Immunology. 1994 Apr; 81(4):618-25. PMID: 8039813; PMCID: PMC1422372

Apt AS, Avdienko VG, Nikonenko BV, Kramnik IB, Moroz AM, Skamene E. Distinct H-2 complex control of mortality, and immune responses to tuberculosis infection in virgin and BCG-vaccinated mice. Clin Exp Immunol. 1993 Nov; 94(2):322-9. PMID: 8222323; PMCID: PMC1534249

Kramnik I, Skamene E, Radzioch D. Assessment of lymphokine profiles in activated lymphocytes by semiquantitative PCR. J Immunol Methods. 1993 Jun 18; 162(2):143-53. PMID: 7686197

Avdienko VG, Kramnik IB, Apt AS, Litvinov VI. [The isolation and testing of syngeneic anti-idiotypic antibodies against antimycobacterial monoclonal antibodies]. Probl Tuberk. 1993; (1):47-50. PMID: 7687055

Apt AS, Kramnik IB, Moroz AM. Regulation of T-cell proliferative responses by cells from solid lung tissue of M. tuberculosis-infected mice. Immunology. 1991 Jun; 73(2):173-9. PMID: 2071162; PMCID: PMC1384461

Kramnik IG, Moroz AM, Apt AS. [Cellular mechanisms of suppression of T-lymphocyte proliferation by lung cells in experimental tuberculosis]. Biull Eksp Biol Med. 1990 Aug; 110(8):172-6. PMID: 1705456

Kramnik IB, Apt AS, Moroz AM. [Suppression of immune response by lung cells in experimental tuberculosis]. Biull Eksp Biol Med. 1990 Jul; 110(7):77-80. PMID: 2145988

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 69 publications over 28 distinct years, with a maximum of 6 publications in 2012