Keywords
Last Name

Aaron Beeler, PhD

TitleAssistant Professor
InstitutionBoston University College of Arts and Sciences
DepartmentChemistry
Address590 Commonwealth Avenue
Boston MA 02215
Phone (617) 358-3487
Fax(617) 358-2847
Other Positions
TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics

 Research Expertise & Professional Interests
Aaron Beeler received his Ph.D. in 2002 from Professor John Rimoldi’s laboratory in the Department of Medicinal Chemistry at the University of Mississippi. He then joined the Porco group as a postodoctoral fellow and subsequently the Center for Chemical Methodology and Library Development at Boston University, now the Center for Molecular Discovery. He was promoted to Assistant Director of the CMLD-BU in January 2005. In 2012 Aaron joined the Department of Chemistry as a tenure-track professor in medicinal chemistry.

RESEARCH

The Beeler Research Group is truly multidisciplinary, combining organic chemistry, engineering, and biology to solve problems in medicinal chemistry. All of these elements are combined and directed toward significant problems in human health. The Beeler Group is addressing focused disease areas (e.g., schizophrenia, Parkinson’s, cystic fibrosis), as well as project areas with broader impact potential (e.g., new methods for discovery of small molecules with anti-cancer properties).

Medicinal Chemistry: The goals of medicinal chemistry projects are to optimize small molecules in order to: a) develop a probe that may be utilized as a tool in biological studies; b) develop a lead molecule to facilitate future therapeutics; and c) utilize small molecules to enhance understanding of biological targets that are important for human health. These projects provide students with training in organic chemistry, medicinal chemistry, and focused biology. Projects are selected based on their chemistry and/or biology significance and potential for addressing challenging questions.

Technology: One of the core components of the research in the Beeler Group is development of technologies and paradigms that facilitate rapid modification of complex scaffolds. These technologies enable optimization of biologically active lead compounds and identification of small molecule leads in biological systems. The projects focus on utilizing automation, miniaturization, and microfluidics to carry out chemical transformations. These projects are highly interdisciplinary with both chemistry and engineering components.

Photochemistry: This area focuses on photochemical transformations toward the synthesis of natural products, natural product scaffolds, and other complex chemotypes of interest to medicinal chemistry and chemical biology. The foundation of these projects is utilizing microfluidics to enable photochemical reaction development.

TECHNIQUES & RESOURCES

Students in the Beeler Research Group will have opportunities to learn a number of exciting research disciplines. Organic synthesis will be at the heart of every project. This will include targeted synthesis, methodology development, and medicinal chemistry. Through collaborations with biological researchers and/or research projects carried out within the Beeler Group, students will learn methods for biological assays, pharmacology, and target identification. Many projects will also include aspects of engineering that will provide opportunities for learning techniques such as microfabrication and microfluidics.

OPPORTUNITIES

It is becoming evident that successful and impactful science is realized in collaborative interdisciplinary environments. The Beeler Research Group’s multidisciplinary nature and collaborative projects provides opportunities to learn areas of research outside of traditional chemistry.

WHAT'S NEXT FOR GRADUATES OF THE BEELER GROUP?

Members of the Beeler Research Group will be positioned for a wide range of future endeavors:

-Undergraduates will be prepared to enter into graduate school for organic chemistry, chemical biology, or chemical engineering or to start careers in industry;

-Graduate students will have the foundation required for postdoctoral studies in organic synthesis or chemical biology as well as an industrial career in biotech or pharma;

-Postdoctoral associates will gain training and experience critical for both academic and industrial careers.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Imberdis T, Heeres JT, Yueh H, Fang C, Zhen J, Rich CB, Glicksman M, Beeler AB, Harris DA. Identification of Anti-prion Compounds using a Novel Cellular Assay. J Biol Chem. 2016 Dec 09; 291(50):26164-26176. PMID: 27803163.
    View in: PubMed
  2. Beeler AB. Introduction: Photochemistry in Organic Synthesis. Chem Rev. 2016 Sep 14; 116(17):9629-30. PMID: 27625298.
    View in: PubMed
  3. Ingham OJ, Paranal RM, Smith WB, Escobar RA, Yueh H, Snyder T, Porco JA, Bradner JE, Beeler AB. Development of a Potent and Selective HDAC8 Inhibitor. ACS Med Chem Lett. 2016 Oct 13; 7(10):929-932. PMID: 27774131.
    View in: PubMed
  4. Bhattacharya B, Chatterjee S, Devine WG, Kobzik L, Beeler AB, Porco JA, Kramnik I. Fine-tuning of macrophage activation using synthetic rocaglate derivatives. Sci Rep. 2016 Apr 18; 6:24409. PMID: 27086720.
    View in: PubMed
  5. Hancock WW, Wang L, Newick K, Beeler AB, Albelda SM. Abstract A03: Inhibition of the histone/protein acetyltransferase, Tip60, impairs Foxp3 acetylation and Treg function and thereby promotes antitumor immunity. Cancer Research. 2016; 76(3 suppl):A03.
    View in: External Website
  6. Yueh H, Voevodin A, Beeler AB. Development of a photolabile amine protecting group suitable for multistep flow synthesis. Journal of Flow Chemistry. 2015; 5(3):155-159.
    View in: External Website
  7. Beeler AB, Corning SR. Photochemistry in flow. Photochemistry. Royal Society of Chemistry. 2015; 43:175.
    View in: External Website
  8. Telmesani R, Park SH, Lynch-Colameta T, Beeler AB. [2+2] Photocycloaddition of Cinnamates in Flow and Development of a Thiourea Catalyst. Angew Chem Int Ed Engl. 2015 Sep 21; 54(39):11521-5. PMID: 26136253.
    View in: PubMed
  9. Martin VI, Goodell JR, Ingham OJ, Porco JA, Beeler AB. Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes. J Org Chem. 2014 May 2; 79(9):3838-46. PMID: 24697145.
    View in: PubMed
  10. Leng B, Chichetti S, Su S, Beeler AB, Porco JA. Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations. Beilstein J Org Chem. 2012; 8:1338-43. PMID: 23019468.
    View in: PubMed
  11. Achard M, Beeler AB, Porco JA. Synthesis of azaphilone-based chemical libraries. ACS Comb Sci. 2012 Mar 12; 14(3):236-44. PMID: 22330196.
    View in: PubMed
  12. Pimparkar K, Yen B, Goodell JR, Martin VI, Lee WH, Porco JA, Beeler AB, Jensen KF. Development of a Photochemical Microfluidics Platform. Journal of Flow Chemistry. 2011; 1(2):53-55.
    View in: External Website
  13. Balthaser BR, Maloney MC, Beeler AB, Porco JA, Snyder JK. Remodelling of the natural product fumagillol employing a reaction discovery approach. Nat Chem. 2011 Dec; 3(12):969-73. PMID: 22213919.
    View in: PubMed
  14. Goodell JR, Poole JL, Beeler AB, Aubé J, Porco JA. Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes. J Org Chem. 2011 Dec 2; 76(23):9792-800. PMID: 22007996.
    View in: PubMed
  15. Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6775-80. PMID: 21498685.
    View in: PubMed
  16. Albini A, Fasani E, Amendola V, Araki K, Beeler AB, Briceño A, Fausto R, Friend R, MacGillivray L, Monti S, Puntoriero F, Seixas de Melo JS. Photochemistry. Royal Society of Chemistry. 2011.
    View in: External Website
  17. Qi J, Beeler AB, Zhang Q, Porco JA. Catalytic enantioselective alkylative dearomatization-annulation: total synthesis and absolute configuration assignment of hyperibone K. J Am Chem Soc. 2010 Oct 6; 132(39):13642-4. PMID: 20831187.
    View in: PubMed
  18. Goodell JR, Leng B, Snyder TK, Beeler AB, Porco JA. Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones. Synthesis (Stuttg). 2010 Jul 01; 2010(13):2254-2270. PMID: 25132691.
    View in: PubMed
  19. Kinoshita H, Ingham OJ, Ong WW, Beeler AB, Porco JA. Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation. J Am Chem Soc. 2010 May 12; 132(18):6412-8. PMID: 20394364.
    View in: PubMed
  20. Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD. A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization. Assay Drug Dev Technol. 2010 Feb; 8(1):96-105. PMID: 20035614.
    View in: PubMed
  21. Goodell JR, McMullen JP, Zaborenko N, Maloney JR, Ho CX, Jensen KF, Porco JA, Beeler AB. Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds. J Org Chem. 2009 Aug 21; 74(16):6169-80. PMID: 20560568.
    View in: PubMed
  22. Han C, Rangarajan S, Voukides AC, Beeler AB, Johnson R, Porco JA. Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams. Org Lett. 2009 Jan 15; 11(2):413-6. PMID: 19102683.
    View in: PubMed
  23. Zhou Y, Beeler AB, Cho S, Wang Y, Franzblau SG, Snyder JK. Library synthesis using 5,6,7,8-tetrahydro-1,6-naphthyridines as scaffolds. J Comb Chem. 2008 Jul-Aug; 10(4):534-40. PMID: 18517255.
    View in: PubMed
  24. Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA, Schreiber SL, Chung RT. Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrob Agents Chemother. 2007 Oct; 51(10):3756-9. PMID: 17682098.
    View in: PubMed
  25. Woo GH, Beeler AB, Snyder JK. 1,2,3,4-Tetrahydro-1,5-naphthyridines and related heterocyclic scaffolds: Exploration of suitable chemistry for library development. Tetrahedron. 2007 Jun 18; 63(25):5649-5655. PMID: 19112520.
    View in: PubMed
  26. Choi SR, Beeler AB, Pradhan A, Watkins EB, Rimoldi JM, Tekwani B, Avery MA. Generation of oxamic acid libraries: antimalarials and inhibitors of Plasmodium falciparum lactate dehydrogenase. J Comb Chem. 2007 Mar-Apr; 9(2):292-300. PMID: 17316052.
    View in: PubMed
  27. Beeler AB, Su S, Singleton CA, Porco JA. Discovery of chemical reactions through multidimensional screening. J Am Chem Soc. 2007 Feb 7; 129(5):1413-9. PMID: 17263426.
    View in: PubMed
  28. Ong WW, Beeler AB, Kesavan S, Panek JS, Porco JA. Nucleophilic addition to N-phosphinylimines by rare-earth-metal triflate/trifluoroacetic anhydride activation. Angew Chem Int Ed Engl. 2007; 46(39):7470-2. PMID: 17722135.
    View in: PubMed
  29. Dandapani S, Lan P, Beeler AB, Beischel S, Abbas A, Roth BL, Porco JA, Panek JS. Convergent synthesis of complex diketopiperazines derived from pipecolic acid scaffolds and parallel screening against GPCR targets. J Org Chem. 2006 Nov 10; 71(23):8934-45. PMID: 17081025.
    View in: PubMed
  30. Beeler AB, Acquilano DE, Su Q, Yan F, Roth BL, Panek JS, Porco JA. Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters. J Comb Chem. 2005 Sep-Oct; 7(5):673-81. PMID: 16153061.
    View in: PubMed
  31. Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Org Lett. 2005 Jun 23; 7(13):2751-4. PMID: 15957938.
    View in: PubMed
  32. Beeler AB, Schaus SE, Porco JA. Chemical library synthesis using convergent approaches. Curr Opin Chem Biol. 2005 Jun; 9(3):277-84. PMID: 15939329.
    View in: PubMed
  33. Beeler AB, Gadepalli RS, Steyn S, Castagnoli N, Rimoldi JM. Synthesis and in vitro biological evaluation of fluoro-substituted-4-phenyl-1,2,3,6-tetrahydropyridines as monoamine oxidase B substrates. Bioorg Med Chem. 2003 Nov 17; 11(23):5229-34. PMID: 14604687.
    View in: PubMed
  34. Su Q, Beeler AB, Lobkovsky E, Porco JA, Panek JS. Stereochemical diversity through cyclodimerization: synthesis of polyketide-like macrodiolides. Org Lett. 2003 Jun 12; 5(12):2149-52. PMID: 12790551.
    View in: PubMed
  35. Schlenk D, Huggett DB, Allgood J, Bennett E, Rimoldi J, Beeler AB, Block D, Holder AW, Hovinga R, Bedient P. Toxicity of fipronil and its degradation products to Procambarus sp.: field and laboratory studies. Arch Environ Contam Toxicol. 2001 Oct; 41(3):325-32. PMID: 11503069.
    View in: PubMed
  36. Beeler AB, Schlenk DK, Rimoldi JM. Synthesis of fipronil sulfide, an active metabolite, from the parent insecticide fipronil. Tetrahedron Letters. 2001; 42(32):5371–5372.
    View in: External Website
Aaron's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
BU Co-Authors
_
Similar BU People
_
Same Department