Keywords
Last Name

Scott Schaus, PhD

TitleAssociate Professor
InstitutionBoston University College of Arts and Sciences
DepartmentChemistry
Address24 Cummington Mall
Boston MA 02215
Phone(617) 353-2489
Fax(617) 353-6466
Other Positions
TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics

 Research Expertise & Professional Interests
Professor Schaus received his Ph.D. in Organic Chemistry with Eric N. Jacobsen at Harvard University in 1999 and did postdoctoral studies in Andy Myers’ laboratory at Harvard University as an NIH fellow.

Research in the Schaus Group is focused in two major areas: enantioselective catalytic synthetic methodologies for chemical synthesis and biomedical research, the latter conducted at the Boston University Center for Molecular Discovery. Catalytic methods developed in the Schaus Research Laboratories include asymmetric Mannich reactions, enantioselective boronate reactions, and metal-promoted condensation reactions.

Asymmetric Mannich Reactions – The use of cinchona amine, acid, and diol catalysis in the synthesis of chiral amines and heterocycles.

Enantioselective Boronate Catalysis – The development of methodologies to construct chiral building blocks and natural products using boronates.

Biomedical Research – In conjunction with the CMD-BU, advance translational science in the treatment of cancer and infectious disease.

Hepatocellular Carcinoma – Taking on liver cancer in the lab.

Neglected Tropical Disease – BU Researchers Work against Deadly, Disfiguring Disease. Pharmaceutical giant GSK chooses team in its new competition.

Techniques & Resources:

Organic Synthesis techniques are used and include modern methods for synthesis, purification, and analysis of organic molecules.

The Center for Molecular Discovery (CMD-BU) is an NIH-funded Center at Boston University which focuses on development of new methodologies for the synthesis of chemical libraries and biomedical research.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Jiang Y, Schaus SE. Asymmetric Petasis Borono-Mannich Allylation Reactions Catalyzed by Chiral Biphenols. Angew Chem Int Ed Engl. 2017 Feb 01; 56(6):1544-1548. PMID: 28052567.
    View in: PubMed
  2. Chin HG, Ponnaluri VK, Zhang G, Estève PO, Schaus SE, Hansen U, Pradhan S. Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression. Oncotarget. 2016 Dec 13; 7(50):83627-83640. PMID: 27845898.
    View in: PubMed
  3. Barbato KS, Luan Y, Ramella D, Panek JS, Schaus SE. Enantioselective Multicomponent Condensation Reactions of Phenols, Aldehydes, and Boronates Catalyzed by Chiral Biphenols. Org Lett. 2015 Dec 4; 17(23):5812-5. PMID: 26576776.
    View in: PubMed
  4. Rajasekaran D, Siddiq A, Willoughby JL, Biagi JM, Christadore LM, Yunes SA, Gredler R, Jariwala N, Robertson CL, Akiel MA, Shen XN, Subler MA, Windle JJ, Schaus SE, Fisher PB, Hansen U, Sarkar D. Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model. Oncotarget. 2015 Sep 22; 6(28):26266-77. PMID: 26313006.
    View in: PubMed
  5. Luan Y, Barbato KS, Moquist PN, Kodama T, Schaus SE. Enantioselective synthesis of 1,2-dihydronaphthalene-1-carbaldehydes by addition of boronates to isochromene acetals catalyzed by tartaric acid. J Am Chem Soc. 2015 Mar 11; 137(9):3233-6. PMID: 25715172.
    View in: PubMed
  6. Luan Y, Qi Y, Gao H, Ma Q, Schaus SE. Brønsted Acid/Lewis Acid Cooperatively Catalyzed Addition of Diazoester to 2H-chromene Acetals. European J Org Chem. 2014 Nov 1; 2014(31):6868-6872. PMID: 25411552.
    View in: PubMed
  7. Luan Y, Yu J, Zhang X, Schaus SE, Wang G. Diastereoselective three-component synthesis of ß-amino carbonyl compounds using diazo compounds, boranes, and acyl imines under catalyst-free conditions. J Org Chem. 2014 May 16; 79(10):4694-8. PMID: 24787904.
    View in: PubMed
  8. Christadore LM, Pham L, Kolaczyk ED, Schaus SE. Improvement of experimental testing and network training conditions with genome-wide microarrays for more accurate predictions of drug gene targets. BMC Syst Biol. 2014; 8:7. PMID: 24444313.
    View in: PubMed
  9. Luan Y, Qi Y, Yu J, Gao H, Schaus SE. The development of a novel HAuCl4@MOF catalyst and its catalytic application in the formation of dihydrochalcones. RSC Adv. 2014 Jan 1; 4(64):34199-34203. PMID: 26989477.
    View in: PubMed
  10. Zandparsa R, Talua NA, Finkelman MD, Schaus SE. An in vitro comparison of shear bond strength of zirconia to enamel using different surface treatments. J Prosthodont. 2014 Feb; 23(2):117-23. PMID: 23890275.
    View in: PubMed
  11. Xiong Y, Schaus SE, Porco JA. Metal-catalyzed cascade rearrangements of 3-alkynyl flavone ethers. Org Lett. 2013 Apr 19; 15(8):1962-5. PMID: 23574045.
    View in: PubMed
  12. Peritore CS, Ho A, Yamamoto BK, Schaus SE. Resveratrol attenuates L-DOPA-induced hydrogen peroxide toxicity in neuronal cells. Neuroreport. 2012 Dec 5; 23(17):989-94. PMID: 23114623.
    View in: PubMed
  13. Luan Y, Schaus SE. Enantioselective addition of boronates to o-quinone methides catalyzed by chiral biphenols. J Am Chem Soc. 2012 Dec 12; 134(49):19965-8. PMID: 23206197.
    View in: PubMed
  14. Ma Z, Ni F, Woo GH, Lo SM, Roveto PM, Schaus SE, Snyder JK. An intramolecular inverse electron demand Diels-Alder approach to annulated a-carbolines. Beilstein J Org Chem. 2012; 8:829-40. PMID: 23015831.
    View in: PubMed
  15. Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SE, Hansen U, Fisher PB, Sarkar D. The transcription factor LSF: a novel oncogene for hepatocellular carcinoma. Am J Cancer Res. 2012; 2(3):269-85. PMID: 22679558.
    View in: PubMed
  16. Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U. Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4503-8. PMID: 22396589.
    View in: PubMed
  17. Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. J Virol. 2012 Mar; 86(5):2632-40. PMID: 22205744.
    View in: PubMed
  18. Luan Y, Sun H, Schaus SE. Iron-catalyzed rearrangements and cycloaddition reactions of 2H-chromenes. Org Lett. 2011 Dec 16; 13(24):6480-3. PMID: 22098535.
    View in: PubMed
  19. Kodama T, Moquist PN, Schaus SE. Enantioselective boronate additions to N-acyl quinoliniums catalyzed by tartaric acid. Org Lett. 2011 Dec 2; 13(23):6316-9. PMID: 22067040.
    View in: PubMed
  20. Pham L, Christadore L, Schaus S, Kolaczyk ED. Network-based prediction for sources of transcriptional dysregulation using latent pathway identification analysis. Proc Natl Acad Sci U S A. 2011 Aug 9; 108(32):13347-52. PMID: 21788508.
    View in: PubMed
  21. Brown LE, Dai P, Porco JA, Schaus SE. Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Org Lett. 2011 Aug 19; 13(16):4228-31. PMID: 21749159.
    View in: PubMed
  22. Muncipinto G, Moquist PN, Schreiber SL, Schaus SE. Catalytic diastereoselective petasis reactions. Angew Chem Int Ed Engl. 2011 Aug 22; 50(35):8172-5. PMID: 21751322.
    View in: PubMed
  23. Medeiros MR, Schaus SE, Porco JA. A cycloisomerization/Friedel-Crafts alkylation strategy for the synthesis of pyrano[3,4-b]indoles. Org Lett. 2011 Aug 5; 13(15):4012-5. PMID: 21740020.
    View in: PubMed
  24. Barnett DS, Schaus SE. Asymmetric propargylation of ketones using allenylboronates catalyzed by chiral biphenols. Org Lett. 2011 Aug 5; 13(15):4020-3. PMID: 21732609.
    View in: PubMed
  25. Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6775-80. PMID: 21498685.
    View in: PubMed
  26. Luan Y, Schaus SE. Multicomponent Mannich reactions with boron enolates derived from diazo esters and 9-BBN. Org Lett. 2011 May 6; 13(9):2510-3. PMID: 21473584.
    View in: PubMed
  27. Moquist PN, Kodama T, Schaus SE. Enantioselective addition of boronates to chromene acetals catalyzed by a chiral Brønsted acid/Lewis acid system. Angew Chem Int Ed Engl. 2010 Sep 17; 49(39):7096-100. PMID: 20721997.
    View in: PubMed
  28. Goldstein C, Schroeder JC, Fortin JP, Goss JM, Schaus SE, Beinborn M, Kopin AS. Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling. J Pharmacol Exp Ther. 2010 Dec; 335(3):799-806. PMID: 20833795.
    View in: PubMed
  29. Medeiros MR, Narayan RS, McDougal NT, Schaus SE, Porco JA. Skeletal diversity via cationic rearrangements of substituted dihydropyrans. Org Lett. 2010 Jul 16; 12(14):3222-5. PMID: 20550144.
    View in: PubMed
  30. Marié JC, Xiong Y, Min GK, Yeager AR, Taniguchi T, Berova N, Schaus SE, Porco JA. Enantioselective synthesis of 3,4-chromanediones via asymmetric rearrangement of 3-allyloxyflavones. J Org Chem. 2010 Jul 2; 75(13):4584-90. PMID: 20527786.
    View in: PubMed
  31. Ting A, Goss JM, McDougal NT, Schaus SE. Brønsted base catalysts. Top Curr Chem. 2010; 291:145-200. PMID: 21494951.
    View in: PubMed
  32. Barnett DS, Moquist PN, Schaus SE. The mechanism and an improved asymmetric allylboration of ketones catalyzed by chiral biphenols. Angew Chem Int Ed Engl. 2009; 48(46):8679-82. PMID: 19816902.
    View in: PubMed
  33. Bishop JA, Lou S, Schaus SE. Enantioselective addition of boronates to acyl imines catalyzed by chiral biphenols. Angew Chem Int Ed Engl. 2009; 48(24):4337-40. PMID: 19431168.
    View in: PubMed
  34. Goss JM, Schaus SE. Enantioselective synthesis of SNAP-7941: chiral dihydropyrimidone inhibitor of MCH1-R. J Org Chem. 2008 Oct 3; 73(19):7651-6. PMID: 18767801.
    View in: PubMed
  35. Lou S, Schaus SE. Asymmetric petasis reactions catalyzed by chiral biphenols. J Am Chem Soc. 2008 Jun 4; 130(22):6922-3. PMID: 18459782.
    View in: PubMed
  36. Lou S, Dai P, Schaus SE. Asymmetric Mannich reaction of dicarbonyl compounds with alpha-amido sulfones catalyzed by cinchona alkaloids and synthesis of chiral dihydropyrimidones. J Org Chem. 2007 Dec 21; 72(26):9998-10008. PMID: 18047372.
    View in: PubMed
  37. Lou S, Moquist PN, Schaus SE. Asymmetric allylboration of acyl imines catalyzed by chiral diols. J Am Chem Soc. 2007 Dec 12; 129(49):15398-404. PMID: 18020334.
    View in: PubMed
  38. Dominguez MM, Wathier M, Grinstaff MW, Schaus SE. Immobilized hydrogels for screening of molecular interactions. Anal Chem. 2007 Feb 1; 79(3):1064-6. PMID: 17263336.
    View in: PubMed
  39. Yeager AR, Min GK, Porco JA, Schaus SE. Exploring skeletal diversity via ring contraction of glycal-derived scaffolds. Org Lett. 2006 Oct 26; 8(22):5065-8. PMID: 17048844.
    View in: PubMed
  40. Lou S, Moquist PN, Schaus SE. Asymmetric allylboration of ketones catalyzed by chiral diols. J Am Chem Soc. 2006 Oct 4; 128(39):12660-1. PMID: 17002355.
    View in: PubMed
  41. Landon MR, Schaus SE. JEDA: Joint entropy diversity analysis. An information-theoretic method for choosing diverse and representative subsets from combinatorial libraries. Mol Divers. 2006 Aug; 10(3):333-9. PMID: 17031536.
    View in: PubMed
  42. Rodgen SA, Schaus SE. Efficient construction of the clerodane decalin core by an asymmetric Morita-Baylis-Hillman reaction/Lewis acid promoted annulation strategy. Angew Chem Int Ed Engl. 2006 Jul 24; 45(30):4929-32. PMID: 16802391.
    View in: PubMed
  43. Ting A, Lou S, Schaus SE. Highly diastereoselective asymmetric Mannich reactions of 1,3-dicarbonyls with acyl imines. Org Lett. 2006 May 11; 8(10):2003-6. PMID: 16671767.
    View in: PubMed
  44. McDougal NT, Schaus SE. Highly diastereoselective synthesis of bicyclo[3.2.1]octenones through phosphine-mediated condensations of 1,4-dien-3-ones. Angew Chem Int Ed Engl. 2006 May 5; 45(19):3117-9. PMID: 16596692.
    View in: PubMed
  45. Lou S, Taoka BM, Ting A, Schaus SE. Asymmetric Mannich reactions of beta-keto esters with acyl imines catalyzed by cinchona alkaloids. J Am Chem Soc. 2005 Aug 17; 127(32):11256-7. PMID: 16089450.
    View in: PubMed
  46. Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Org Lett. 2005 Jun 23; 7(13):2751-4. PMID: 15957938.
    View in: PubMed
  47. Beeler AB, Schaus SE, Porco JA. Chemical library synthesis using convergent approaches. Curr Opin Chem Biol. 2005 Jun; 9(3):277-84. PMID: 15939329.
    View in: PubMed
  48. di Bernardo D, Thompson MJ, Gardner TS, Chobot SE, Eastwood EL, Wojtovich AP, Elliott SJ, Schaus SE, Collins JJ. Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks. Nat Biotechnol. 2005 Mar; 23(3):377-83. PMID: 15765094.
    View in: PubMed
  49. Lou S, Westbrook JA, Schaus SE. Decarboxylative aldol reactions of allyl beta-keto esters via heterobimetallic catalysis. J Am Chem Soc. 2004 Sep 22; 126(37):11440-1. PMID: 15366881.
    View in: PubMed
  50. McDougal NT, Schaus SE. Asymmetric Morita-Baylis-Hillman reactions catalyzed by chiral Brønsted acids. J Am Chem Soc. 2003 Oct 8; 125(40):12094-5. PMID: 14518986.
    View in: PubMed
  51. Eastwood EL, Schaus SE. Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-dependent pathway. Bioorg Med Chem Lett. 2003 Jul 7; 13(13):2235-7. PMID: 12798341.
    View in: PubMed
  52. Myers AG, Glatthar R, Hammond M, Harrington PM, Kuo EY, Liang J, Schaus SE, Wu Y, Xiang JN. Development of an enantioselective synthetic route to neocarzinostatin chromophore and its use for multiple radioisotopic incorporation. J Am Chem Soc. 2002 May 15; 124(19):5380-401. PMID: 11996579.
    View in: PubMed
  53. Plowright AT, Schaus SE, Myers AG. Transcriptional response pathways in a yeast strain sensitive to saframycin a and a more potent analog: evidence for a common basis of activity. Chem Biol. 2002 May; 9(5):607-18. PMID: 12031667.
    View in: PubMed
  54. Schaus SE, Brandes BD, Larrow JF, Tokunaga M, Hansen KB, Gould AE, Furrow ME, Jacobsen EN. Highly selective hydrolytic kinetic resolution of terminal epoxides catalyzed by chiral (salen)Co(III) complexes. Practical synthesis of enantioenriched terminal epoxides and 1,2-diols. J Am Chem Soc. 2002 Feb 20; 124(7):1307-15. PMID: 11841300.
    View in: PubMed
  55. Schaus SE, Cavalieri D, Myers AG. Gene transcription analysis of Saccharomyces cerevisiae exposed to neocarzinostatin protein-chromophore complex reveals evidence of DNA damage, a potential mechanism of resistance, and consequences of prolonged exposure. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11075-80. PMID: 11562456.
    View in: PubMed
  56. Schaus SE, Jacobsen EN. Asymmetric ring opening of meso epoxides with TMSCN catalyzed by (pybox)lanthanide complexes. Org Lett. 2000 Apr 6; 2(7):1001-4. PMID: 10768207.
    View in: PubMed
  57. Furrow ME, Schaus SE, Jacobsen EN. Practical Access to Highly Enantioenriched C-3 Building Blocks via Hydrolytic Kinetic Resolution. J Org Chem. 1998 Oct 02; 63(20):6776-6777. PMID: 11672291.
    View in: PubMed
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