John Porco | Profiles RNS

John A. Porco, PhD

Professor

Boston University College of Arts and Sciences

Dept of Chemistry

PhD, Harvard University
DEng, College of the Holy Cross
MS, Yale University

Websites

	Chemistry Faculty
	Porco Group Home Page
	Center for Molecular Discovery (BU-CMD)
	Google Scholar

John Porco investigates chemical syntheses of complex molecules and synthesis of complex chemical libraries of novel structural types. John joined the Department of Chemistry at Boston University in 1999 after a successful career in industry and was rapidly promoted to Professor of Chemistry in September 2004.

Research in the Porco Group is focused in two major areas: the development of new synthetic methodologies for efficient chemical synthesis of complex molecules and synthesis of complex chemical libraries, the latter conducted at the Boston University Center for Molecular Discovery. Synthetic methodologies developed in the Porco Laboratory include copper (I)-mediated formation of enamides, oxa-electrocyclization/dimerization of dienals enroute to complex epoxyquinoids; enantioselective oxidative dearomatization using chiral copper complexes and molecular oxygen; photocycloaddition using oxidopyryliums enroute to the rocaglamides and related natural products, and catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes.

-Dearomatization Strategies in Complex Synthesis aim to utilize aromatic scaffolds as starting materials as precursors to complex natural products.

-Faculty Profile Scientific Image Porco 1Biomimetic Synthesis Approaches involve development of methodologies to test plausible biosyntheses of complex natural products and derivatives.

-New Reaction Discovery is done in conjunction with the BU-CMD and aims to discover transformations leading to novel chemotypes.

Techniques & Resources:

-Organic Synthesis techniques are used and include modern methods for synthesis, purification, and analysis of organic molecules
.
-Boston University Center for Molecular Discovery (BU-CMD) is an NIH-funded Center at Boston University which focuses on development of new methodologies for the synthesis of complex chemical libraries.

Professor
Boston University School of Medicine
Pharmacology & Experimental Therapeutics

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

BU Research
NIH RePORTER Research

Chemical Sythesis of Complex natural Products for Translational Science
05/01/2016 - 04/30/2021 (Multi-PI)
PI: John A. Porco, PhD
NIH/National Institute of General Medical Sciences
3R35GM118173-04S1

HCV Entry: Mechanisms and Therapeutics
09/26/2016 - 05/31/2020 (Subcontract PI)
SRI International NIH NIDDK
5R01DK088787-07

Synthesis of Cannabidiol (CBD)
08/05/2019 - 05/04/2020 (PI)
CBDQURE, Inc.

High-Throughput Chemistry Platform (HTCP) for Reaction Screening
01/01/2018 - 03/31/2019 (Co-PI)
PI: Aaron Beeler, PhD
Department of Defense/DARPA

Center for Molecular Discovery (CMD): A Small Molecule Resource for Biomedical Research
07/01/2015 - 06/30/2018 (PI)
NIH/National Institute of General Medical Sciences
5R24GM111625-03

Development of Novel APP Dimerization Inhibitors that Lower A-beta Levels
09/01/2015 - 04/01/2018 (SP Co-PI of Sub-Project / SP)
PI: Carmela R. Abraham, PhD
Cure Alzheimer's Fund

Elucidating the T Brachyury pathway in Chordoma Using a Chemical Biology Approach
07/01/2017 - 03/31/2018 (Subcontract PI)
The Brigham and Women's Hospital, Inc. Chordoma Foundation

Inhibiting the Heat Shock Factor 1-Regulated Transcriptional Program in Cancers
04/01/2013 - 03/31/2017 (Subcontract PI)
Whitehead Institute for Biomedical Research NIH NCI
5R01CA175744-03

Chemical Synthesis of Bioactive Flavonoid and Xanthone-Derived Natural Products
02/01/2012 - 01/31/2017 (PI)
NIH/National Institute of General Medical Sciences
5R01GM099920-04

Target validation and development of drug discovery platform for TREM2/TYROBP signaling pathway modular
11/01/2014 - 10/31/2016 (Co-PI)
PI: Tsuneya Ikezu, MD, PhD
Massachusetts Neuroscience Consortium

Showing 10 of 15 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2020	BU-CMD Chemical Library Consortium: Fostering Collaborations between Chemists and Biologists for Translational Discovery	1U01TR002625-01A1
2020	Chemical Synthesis of Complex Natural Products for Translational Science	5R35GM118173-05	26
2019	Chemical Synthesis of Complex Natural Products for Translational Science	5R35GM118173-04	26
2019	Acquisition of a helium recovery system for Nuclear Magnetic Resonance (NMR) and Ion Cyclotron Resonance Mass (ICR-MS) Spectrometers	3R35GM118173-04S1	26
2018	Chemical Synthesis of Complex Natural Products for Translational Science	5R35GM118173-03	26
2018	Acquisition of an UltraPerformance Convergence Chromatography (UPC2) System for Synthetic Chemistry Research	3R35GM118173-03S1	26
2017	Chemical Synthesis of Complex Natural Products for Translational Science	5R35GM118173-02	26
2017	Center for Molecular Discovery (CMD): A Small Molecule Resource for Biomedical Research	5R24GM111625-03	28
2016	Chemical Synthesis of Complex Natural Products for Translational Science	1R35GM118173-01	26
2016	Center for Molecular Discovery (CMD): A Small Molecule Resource for Biomedical Research	5R24GM111625-02	28

Showing 10 of 77 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Abe I, Mitsuhashi T, Barra L, Powers Z, Kojasoy V, Cheng A, Yang F, Taniguchi Y, Kikuchi T, Fujita M, Tantillo DJ, Porco JA. Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids. Angew Chem Int Ed Engl. 2020 Sep 15. PMID: 32931152

Liu H, He XZ, Feng MY, Yuan-Zeng, Rauwolf TJ, Shao LD, Ni W, Yan H, Porco JA, Hao XJ, Qin XJ, Liu HY. Acylphloroglucinols with acetylcholinesterase inhibitory effects from the fruits of Eucalyptus robusta. Bioorg Chem. 2020 Oct; 103:104127. PMID: 32745755

Iyer KR, Whitesell L, Porco JA, Henkel T, Brown LE, Robbins N, Cowen LE. Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris. mBio. 2020 03 10; 11(2). PMID: 32156828

Chu J, Zhang W, Cencic R, O'Connor PBF, Robert F, Devine WG, Selznick A, Henkel T, Merrick WC, Brown LE, Baranov PV, Porco JA, Pelletier J. Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F. Cell Rep. 2020 Feb 25; 30(8):2481-2488.e5. PMID: 32101697

Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, Brown LE, Porco JA, Pollak M, Larsson O, Pelletier J, Chio IIC. eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nat Commun. 2019 11 13; 10(1):5151. PMID: 31723131

Powers Z, Scharf A, Cheng A, Yang F, Himmelbauer M, Mitsuhashi T, Barra L, Taniguchi Y, Kikuchi T, Fujita M, Abe I, Porco JA. Biomimetic Synthesis of Meroterpenoids by Dearomatization-Driven Polycyclization. Angew Chem Int Ed Engl. 2019 11 04; 58(45):16141-16146. PMID: 31515901

Purgett TJ, Dyer MW, Bickel B, McNeely J, Porco JA. Gold(I)-Mediated Cycloisomerization/Cycloaddition Enables Bioinspired Syntheses of Neonectrolides B-E and Analogues. J Am Chem Soc. 2019 09 25; 141(38):15135-15144. PMID: 31469554

Chu J, Zhang W, Cencic R, Devine WG, Beglov D, Henkel T, Brown LE, Vajda S, Porco JA, Pelletier J. Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chem Biol. 2019 11 21; 26(11):1586-1593.e3. PMID: 31519508

Gonçalves AC, Towers ER, Haq N, Porco JA, Pelletier J, Dawson SJ, Gale JE. Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity. Sci Rep. 2019 08 29; 9(1):12501. PMID: 31467369

Kong T, Xue Y, Cencic R, Zhu X, Monast A, Fu Z, Pilon V, Sangwan V, Guiot MC, Foulkes WD, Porco JA, Park M, Pelletier J, Huang S. eIF4A Inhibitors Suppress Cell-Cycle Feedback Response and Acquired Resistance to CDK4/6 Inhibition in Cancer. Mol Cancer Ther. 2019 11; 18(11):2158-2170. PMID: 31395685

Showing 10 of 193 results. Show More

Zhang W, Chu J, Cyr AM, Yueh H, Brown LE, Wang TT, Pelletier J, Porco JA. Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors. J Am Chem Soc. 2019 08 14; 141(32):12891-12900. PMID: 31310112

Wen S, Boyce JH, Kandappa SK, Sivaguru J, Porco JA. Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (-)-Nemorosone and (-)-6-epi-Garcimultiflorone A. J Am Chem Soc. 2019 07 17; 141(28):11315-11321. PMID: 31264859

Zhang X, Bi C, Lu T, Zhang W, Yue T, Wang C, Tian T, Zhang X, Huang Y, Lunning M, Hao X, Brown LE, Devine WG, Vose J, Porco JA, Fu K. Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas. Leukemia. 2020 01; 34(1):138-150. PMID: 31171817

Steinberger J, Robert F, Hallé M, Williams DE, Cencic R, Sawhney N, Pelletier D, Williams P, Igarashi Y, Porco JA, Rodriguez AD, Kopp B, Bachmann B, Andersen RJ, Pelletier J. Tracing MYC Expression for Small Molecule Discovery. Cell Chem Biol. 2019 05 16; 26(5):699-710.e6. PMID: 30880156

Qin XJ, Rauwolf TJ, Li PP, Liu H, McNeely J, Hua Y, Liu HY, Porco JA. Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate. Angew Chem Int Ed Engl. 2019 03 22; 58(13):4291-4296. PMID: 30681258

Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA, Kelley MR, Georgiadis MM. Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1. J Med Chem. 2019 02 28; 62(4):1971-1988.View Related Profiles.

Panek, James
Porco, John

PMID: 30653918

Itoua Maïga R, Cencic R, Chu J, Waller DD, Brown LE, Devine WG, Zhang W, Sebag M, Porco JA, Pelletier J. Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation. Sci Rep. 2019 02 04; 9(1):1265. PMID: 30718665

Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA, Tatu U, Brown LE, Pizarro J, Cowen LE. Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun. 2019 01 24; 10(1):402. PMID: 30679438

Zhang W, Liu S, Maiga RI, Pelletier J, Brown LE, Wang TT, Porco JA. Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection. J Am Chem Soc. 2019 01 23; 141(3):1312-1323. PMID: 30590924

Liu S, Hausmann S, Carlson SM, Fuentes ME, Francis JW, Pillai R, Lofgren SM, Hulea L, Tandoc K, Lu J, Li A, Nguyen ND, Caporicci M, Kim MP, Maitra A, Wang H, Wistuba II, Porco JA, Bassik MC, Elias JE, Song J, Topisirovic I, Van Rechem C, Mazur PK, Gozani O. METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis. Cell. 2019 01 24; 176(3):491-504.e21. PMID: 30612740

Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu YY, Zeldich D, Xia W, Van Nostrand WE, Brown LE, Porco JA, Abraham CR. Small Molecule Amyloid-ß Protein Precursor Processing Modulators Lower Amyloid-ß Peptide Levels via cKit Signaling. J Alzheimers Dis. 2019; 67(3):1089-1106.View Related Profiles.

Abraham, Carmela
Chen, Ci-Di
Zeldich, Ella
Porco, John
Xia, Weiming

PMID: 30776010

Smith MJ, Reichl KD, Escobar RA, Heavey TJ, Coker DF, Schaus SE, Porco JA. Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition. J Am Chem Soc. 2019 01 09; 141(1):148-153.View Related Profiles.

Coker, David
Porco, John
Schaus, Scott

PMID: 30566336

Chennamadhavuni S, Panek JS, Porco JA, Brown LE. Diastereodivergent Synthesis of Chiral Tetrahydropyrrolodiazepinediones via a One-Pot Intramolecular aza-Michael/Lactamization Sequence. J Org Chem. 2018 12 21; 83(24):15449-15462.View Related Profiles.

Panek, James
Porco, John

PMID: 30458107

Kearney SE, Zahoránszky-Kohalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci. 2018 Dec 26; 4(12):1727-1741.View Related Profiles.

Porco, John
Snyder, John

PMID: 30648156

Nalli AD, Brown LE, Thomas CL, Sayers TJ, Porco JA, Henrich CJ. Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs. Sci Rep. 2018 11 30; 8(1):17519. PMID: 30504817

Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SA. High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. 2018 09; 129(3):459-476.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 29894316

Qin XJ, Feng MY, Liu H, Ni W, Rauwolf T, Porco JA, Yan H, He L, Liu HY. Eucalyptusdimers A-C, Dimeric Phloroglucinol-Phellandrene Meroterpenoids from Eucalyptus robusta. Org Lett. 2018 08 17; 20(16):5066-5070. PMID: 30088934

Wu X, Iwata T, Scharf A, Qin T, Reichl KD, Porco JA. Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling. J Am Chem Soc. 2018 05 09; 140(18):5969-5975. PMID: 29658717

Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA, Pelletier J, Gros P. Rocaglates as dual-targeting agents for experimental cerebral malaria. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2366-E2375. PMID: 29463745

Qi C, Wang W, Reichl KD, McNeely J, Porco JA. Total Synthesis of Aurofusarin: Studies on the Atropisomeric Stability of Bis-Naphthoquinones. Angew Chem Int Ed Engl. 2018 02 19; 57(8):2101-2104. PMID: 29318760

Wang W, Clay A, Krishnan R, Lajkiewicz NJ, Brown LE, Sivaguru J, Porco JA. Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B: Selective Excited-State Intramolecular Proton-Transfer Photocycloaddition. Angew Chem Int Ed Engl. 2017 11 13; 56(46):14479-14482. PMID: 28950418

Reichl KD, Smith MJ, Song MK, Johnson RP, Porco JA. Biomimetic Total Synthesis of (±)-Griffipavixanthone via a Cationic Cycloaddition-Cyclization Cascade. J Am Chem Soc. 2017 10 11; 139(40):14053-14056. PMID: 28942643

Yueh H, Gao Q, Porco JA, Beeler AB. A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues. Bioorg Med Chem. 2017 Dec 01; 25(23):6197-6202.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 28666859

Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA, Ghobrial IM. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10; 9(389).View Related Profiles.

Porco, John
Snyder, John

PMID: 28490664

Boyce JH, Eschenbrenner-Lux V, Porco JA. Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations. J Am Chem Soc. 2016 11 09; 138(44):14789-14797. PMID: 27744695

Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes. European J Org Chem. 2016 Oct; 2016(28):4800-4804. PMID: 28082832; DOI: 10.1002/ejoc.201601003;

Ingham OJ, Paranal RM, Smith WB, Escobar RA, Yueh H, Snyder T, Porco JA, Bradner JE, Beeler AB. Development of a Potent and Selective HDAC8 Inhibitor. ACS Med Chem Lett. 2016 Oct 13; 7(10):929-932.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 27774131

Wang W, Cencic R, Whitesell L, Pelletier J, Porco JA. Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition. Chemistry. 2016 Aug 16; 22(34):12006-10. PMID: 27338157; DOI: 10.1002/chem.201602953;

Chu J, Galicia-Vázquez G, Cencic R, Mills JR, Katigbak A, Porco JA, Pelletier J. CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A. Cell Rep. 2016 Jun 14; 15(11):2340-7. PMID: 27239032; DOI: 10.1016/j.celrep.2016.05.005;

Kärkäs MD, Porco JA, Stephenson CR. Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. Chem Rev. 2016 Sep 14; 116(17):9683-747. PMID: 27120289; DOI: 10.1021/acs.chemrev.5b00760;

Bhattacharya B, Chatterjee S, Devine WG, Kobzik L, Beeler AB, Porco JA, Kramnik I. Fine-tuning of macrophage activation using synthetic rocaglate derivatives. Sci Rep. 2016 Apr 18; 6:24409.View Related Profiles.

Beeler, Aaron
Bhattacharya, Bidisha
Kramnik, Igor
Porco, John

PMID: 27086720; PMCID: PMC4834551; DOI: 10.1038/srep24409;

Gandin V, Masvidal L, Hulea L, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA, St-Pierre J, Pelletier J, Larsson O, Topisirovic I. nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs. Genome Res. 2016 05; 26(5):636-48. PMID: 26984228; PMCID: PMC4864462; DOI: 10.1101/gr.197566.115;

Qi C, Xiong Y, Eschenbrenner-Lux V, Cong H, Porco JA. Asymmetric Syntheses of the Flavonoid Diels-Alder Natural Products Sanggenons C and O. J Am Chem Soc. 2016 Jan 27; 138(3):798-801. PMID: 26735066; PMCID: PMC4863937; DOI: 10.1021/jacs.5b12778;

Qin T, Iwata T, Ransom TT, Beutler JA, Porco JA. Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of "Shapeshifting" Properties. J Am Chem Soc. 2015 Dec 9; 137(48):15225-33. PMID: 26544765; PMCID: PMC4863954; DOI: 10.1021/jacs.5b09825;

Chu J, Cencic R, Wang W, Porco JA, Pelletier J. Translation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status. Mol Cancer Ther. 2016 Jan; 15(1):136-41. PMID: 26586722; PMCID: PMC4707080; DOI: 10.1158/1535-7163.MCT-15-0409;

Gervais A, Lazarski KE, Porco JA. Divergent Total Syntheses of Rhodomyrtosones A and B. J Org Chem. 2015 Oct 2; 80(19):9584-91. PMID: 26351970; PMCID: PMC4643464; DOI: 10.1021/acs.joc.5b01570;

Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway. EBioMedicine. 2015 Nov; 2(11):1600-6. PMID: 26870784; PMCID: PMC4740292; DOI: 10.1016/j.ebiom.2015.09.018;

Yeo AT, Chennamadhavuni S, Whitty A, Porco JA, Gilmore TD. Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines. Molecules. 2015; 20(5):7474-94.View Related Profiles.

Whitty, Adrian
Porco, John
Gilmore, Thomas

PMID: 25915462; PMCID: PMC4863944; DOI: 10.3390/molecules20057474;

Qin T, Skraba-Joiner SL, Khalil ZG, Johnson RP, Capon RJ, Porco JA. Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer. Nat Chem. 2015 Mar; 7(3):234-40. PMID: 25698333; PMCID: PMC4339264; DOI: 10.1038/nchem.2173;

Stone SD, Lajkiewicz NJ, Whitesell L, Hilmy A, Porco JA. Biomimetic kinetic resolution: highly enantio- and diastereoselective transfer hydrogenation of aglain ketones to access flavagline natural products. J Am Chem Soc. 2015 Jan 14; 137(1):525-30. PMID: 25514979; DOI: 10.1021/ja511728b;

Yeung CS, Ziegler RE, Porco JA, Jacobsen EN. Thiourea-catalyzed enantioselective addition of indoles to pyrones: alkaloid cores with quaternary carbons. J Am Chem Soc. 2014 Oct 1; 136(39):13614-7. PMID: 25213353; PMCID: PMC4235369; DOI: 10.1021/ja508523g;

Zhu L, Qi J, Chiao CY, Zhang Q, Porco JA, Faller DV, Dai Y. Identification of a novel polyprenylated acylphloroglucinol-derived SIRT1 inhibitor with cancer-specific anti-proliferative and invasion-suppressing activities. Int J Oncol. 2014 Nov; 45(5):2128-36.View Related Profiles.

Faller, Douglas
Porco, John
Dai, Yan

PMID: 25189993; PMCID: PMC4203335; DOI: 10.3892/ijo.2014.2639;

Robert F, Roman W, Bramoullé A, Fellmann C, Roulston A, Shustik C, Porco JA, Shore GC, Sebag M, Pelletier J. Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13421-6. PMID: 25197055; PMCID: PMC4169926; DOI: 10.1073/pnas.1402650111;

Grenning AJ, Boyce JH, Porco JA. Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation. J Am Chem Soc. 2014 Aug 20; 136(33):11799-804. PMID: 25061804; PMCID: PMC4140454; DOI: 10.1021/ja5060302;

Wolfe AL, Singh K, Zhong Y, Drewe P, Rajasekhar VK, Sanghvi VR, Mavrakis KJ, Jiang M, Roderick JE, Van der Meulen J, Schatz JH, Rodrigo CM, Zhao C, Rondou P, de Stanchina E, Teruya-Feldstein J, Kelliher MA, Speleman F, Porco JA, Pelletier J, Rätsch G, Wendel HG. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature. 2014 Sep 4; 513(7516):65-70. PMID: 25079319; PMCID: PMC4492470; DOI: 10.1038/nature13485;

Villar EA, Beglov D, Chennamadhavuni S, Porco JA, Kozakov D, Vajda S, Whitty A. How proteins bind macrocycles. Nat Chem Biol. 2014 Sep; 10(9):723-31.View Related Profiles.

Whitty, Adrian
Porco, John

PMID: 25038790; PMCID: PMC4417626; DOI: 10.1038/nchembio.1584;

Boyce JH, Porco JA. Asymmetric, stereodivergent synthesis of (-)-clusianone utilizing a biomimetic cationic cyclization. Angew Chem Int Ed Engl. 2014 Jul 21; 53(30):7832-7. PMID: 24916169; PMCID: PMC4182949; DOI: 10.1002/anie.201404437;

Martin VI, Goodell JR, Ingham OJ, Porco JA, Beeler AB. Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes. J Org Chem. 2014 May 2; 79(9):3838-46.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 24697145; PMCID: PMC4017617; DOI: 10.1021/jo500190b;

Qi C, Qin T, Suzuki D, Porco JA. Total synthesis and stereochemical assignment of (±)-sorbiterrin A. J Am Chem Soc. 2014 Mar 5; 136(9):3374-7. PMID: 24547688; PMCID: PMC3978410; DOI: 10.1021/ja500854q;

Qin T, Porco JA. Total syntheses of secalonic acids A and D. Angew Chem Int Ed Engl. 2014 Mar 17; 53(12):3107-10. PMID: 24519991; PMCID: PMC4098722; DOI: 10.1002/anie.201311260;

Lajkiewicz NJ, Cognetta AB, Niphakis MJ, Cravatt BF, Porco JA. Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived ß-lactone. J Am Chem Soc. 2014 Feb 12; 136(6):2659-64. PMID: 24447064; PMCID: PMC3978386; DOI: 10.1021/ja412431g;

Grenning AJ, Snyder JK, Porco JA. Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction. Org Lett. 2014 Feb 7; 16(3):792-5.View Related Profiles.

Porco, John
Snyder, John

PMID: 24410175; PMCID: PMC3927640; DOI: 10.1021/ol4035269;

Bos PH, Antalek MT, Porco JA, Stephenson CR. Tandem dienone photorearrangement-cycloaddition for the rapid generation of molecular complexity. J Am Chem Soc. 2013 Nov 27; 135(47):17978-82. PMID: 24161069; PMCID: PMC3964885; DOI: 10.1021/ja409992m;

Nasr Z, Dow LE, Paquet M, Chu J, Ravindar K, Somaiah R, Deslongchamps P, Porco JA, Lowe SW, Pelletier J. Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia. BMC Pharmacol Toxicol. 2013; 14:58. PMID: 24219888; PMCID: PMC4225821; DOI: 10.1186/2050-6511-14-58;

Winter DK, Endoma-Arias MA, Hudlicky T, Beutler JA, Porco JA. Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a tetrahydroxanthone analogue. J Org Chem. 2013 Aug 2; 78(15):7617-26. PMID: 23834060; PMCID: PMC3773511; DOI: 10.1021/jo401169z;

Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA, Whitesell L, Lindquist S. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science. 2013 Jul 19; 341(6143):1238303. PMID: 23869022; PMCID: PMC3959726; DOI: 10.1126/science.1238303;

Qi C, Cong H, Cahill KJ, Müller P, Johnson RP, Porco JA. Biomimetic dehydrogenative Diels-Alder cycloadditions: total syntheses of brosimones A and B. Angew Chem Int Ed Engl. 2013 Aug 5; 52(32):8345-8. PMID: 23818217; PMCID: PMC3886855; DOI: 10.1002/anie.201302847;

Sadlish H, Galicia-Vazquez G, Paris CG, Aust T, Bhullar B, Chang L, Helliwell SB, Hoepfner D, Knapp B, Riedl R, Roggo S, Schuierer S, Studer C, Porco JA, Pelletier J, Movva NR. Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex. ACS Chem Biol. 2013 Jul 19; 8(7):1519-27. PMID: 23614532; PMCID: PMC3796129; DOI: 10.1021/cb400158t;

Xiong Y, Schaus SE, Porco JA. Metal-catalyzed cascade rearrangements of 3-alkynyl flavone ethers. Org Lett. 2013 Apr 19; 15(8):1962-5.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 23574045; PMCID: PMC3773515; DOI: 10.1021/ol400631b;

Winter DK, Sloman DL, Porco JA. Polycyclic xanthone natural products: structure, biological activity and chemical synthesis. Nat Prod Rep. 2013 Mar; 30(3):382-91. PMID: 23334431; PMCID: PMC3615431; DOI: 10.1039/c3np20122h;

Dong S, Qin T, Hamel E, Beutler JA, Porco JA. Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation. J Am Chem Soc. 2012 Dec 5; 134(48):19782-7. PMID: 23110297; PMCID: PMC3542833; DOI: 10.1021/ja3084708;

Leng B, Chichetti S, Su S, Beeler AB, Porco JA. Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations. Beilstein J Org Chem. 2012; 8:1338-43.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 23019468; PMCID: PMC3458758

Ziegler RE, Tan SJ, Kam TS, Porco JA. Development of an alkaloid-pyrone annulation: synthesis of pleiomaltinine. Angew Chem Int Ed Engl. 2012 Sep 10; 51(37):9348-51. PMID: 22893619; PMCID: PMC3574645; DOI: 10.1002/anie.201204093;

Lajkiewicz NJ, Roche SP, Gerard B, Porco JA. Enantioselective photocycloaddition of 3-hydroxyflavones: total syntheses and absolute configuration assignments of (+)-ponapensin and (+)-elliptifoline. J Am Chem Soc. 2012 Aug 8; 134(31):13108-13. PMID: 22804454; PMCID: PMC3529213; DOI: 10.1021/ja305342f;

Jin C, Rajabi H, Rodrigo CM, Porco JA, Kufe D. Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 2013 Apr 25; 32(17):2179-88. PMID: 22689062; PMCID: PMC3443512; DOI: 10.1038/onc.2012.236;

Porco JA. Recent developments in chemical diversity. Beilstein J Org Chem. 2012; 8:827-8. PMID: 23015830; PMCID: PMC3388870

Little A, Porco JA. Total syntheses of graphisin A and sydowinin B. Org Lett. 2012 Jun 1; 14(11):2862-5. PMID: 22621405; PMCID: PMC3367002; DOI: 10.1021/ol301107m;

Scully SS, Porco JA. Studies toward the synthesis of the epoxykinamycin FL-120B': discovery of a decarbonylative photocyclization. Org Lett. 2012 May 18; 14(10):2646-9. PMID: 22571279; PMCID: PMC3433630; DOI: 10.1021/ol3010563;

Cong H, Porco JA. Total synthesis of (±)-sorocenol B employing nanoparticle catalysis. Org Lett. 2012 May 18; 14(10):2516-9. PMID: 22553903; PMCID: PMC3434240; DOI: 10.1021/ol300800r;

Lin CJ, Nasr Z, Premsrirut PK, Porco JA, Hippo Y, Lowe SW, Pelletier J. Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. Cell Rep. 2012 Apr 19; 1(4):325-33. PMID: 22573234

Nasr Z, Robert F, Porco JA, Muller WJ, Pelletier J. eIF4F suppression in breast cancer affects maintenance and progression. Oncogene. 2013 Feb 14; 32(7):861-71. PMID: 22484424; PMCID: PMC4863948; DOI: 10.1038/onc.2012.105;

Zhang Q, Porco JA. Total synthesis of (±)-7-epi-nemorosone. Org Lett. 2012 Apr 6; 14(7):1796-9. PMID: 22449198; PMCID: PMC3326386; DOI: 10.1021/ol300386t;

Achard M, Beeler AB, Porco JA. Synthesis of azaphilone-based chemical libraries. ACS Comb Sci. 2012 Mar 12; 14(3):236-44.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 22330196; PMCID: PMC3313624; DOI: 10.1021/co300002x;

Cong H, Porco JA. Chemical Synthesis of Complex Molecules Using Nanoparticle Catalysis. ACS Catal. 2012 Jan 01; 2(1):65-70. PMID: 22347681

Rodrigo CM, Cencic R, Roche SP, Pelletier J, Porco JA. Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies. J Med Chem. 2012 Jan 12; 55(1):558-62. PMID: 22128783; PMCID: PMC3263355; DOI: 10.1021/jm201263k;

Yeo AT, Porco JA, Gilmore TD. Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis. Cancer Lett. 2012 May 1; 318(1):53-60.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 22155272; PMCID: PMC3288124; DOI: 10.1016/j.canlet.2011.11.035;

Balthaser BR, Maloney MC, Beeler AB, Porco JA, Snyder JK. Remodelling of the natural product fumagillol employing a reaction discovery approach. Nat Chem. 2011 Dec; 3(12):969-73.View Related Profiles.

Beeler, Aaron
Porco, John
Snyder, John

PMID: 22213919; PMCID: PMC3254213

Deb Majumdar I, Devanabanda A, Fox B, Schwartzman J, Cong H, Porco JA, Weber HC. Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro. Biochem Biophys Res Commun. 2011 Dec 16; 416(3-4):397-402.View Related Profiles.

Weber, H.
Porco, John

PMID: 22120630; DOI: 10.1016/j.bbrc.2011.11.052;

Goodell JR, Poole JL, Beeler AB, Aubé J, Porco JA. Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes. J Org Chem. 2011 Dec 2; 76(23):9792-800.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 22007996; PMCID: PMC3235415; DOI: 10.1021/jo2018922;

Dong S, Cahill KJ, Kang MI, Colburn NH, Henrich CJ, Wilson JA, Beutler JA, Johnson RP, Porco JA. Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers. J Org Chem. 2011 Nov 4; 76(21):8944-54. PMID: 21942286; PMCID: PMC3214659; DOI: 10.1021/jo201658y;

Scully SS, Porco JA. Asymmetric total synthesis of the epoxykinamycin FL-120?B'. Angew Chem Int Ed Engl. 2011 Oct 4; 50(41):9722-6. PMID: 21953671; PMCID: PMC3477604; DOI: 10.1002/anie.201104504;

Schatz JH, Oricchio E, Wolfe AL, Jiang M, Linkov I, Maragulia J, Shi W, Zhang Z, Rajasekhar VK, Pagano NC, Porco JA, Teruya-Feldstein J, Rosen N, Zelenetz AD, Pelletier J, Wendel HG. Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. J Exp Med. 2011 Aug 29; 208(9):1799-807. PMID: 21859846; PMCID: PMC3171093; DOI: 10.1084/jem.20110846;

Brown LE, Dai P, Porco JA, Schaus SE. Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Org Lett. 2011 Aug 19; 13(16):4228-31.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 21749159; PMCID: PMC4251731; DOI: 10.1021/ol2015658;

Medeiros MR, Schaus SE, Porco JA. A cycloisomerization/Friedel-Crafts alkylation strategy for the synthesis of pyrano[3,4-b]indoles. Org Lett. 2011 Aug 5; 13(15):4012-5.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 21740020; PMCID: PMC3146574; DOI: 10.1021/ol201532k;

Sloman DL, Bacon JW, Porco JA. Total synthesis and absolute stereochemical assignment of kibdelone C. J Am Chem Soc. 2011 Jul 6; 133(26):9952-5. PMID: 21648477; PMCID: PMC3134420; DOI: 10.1021/ja203642n;

Wu J, Becerril J, Lian Y, Davies HM, Porco JA, Panek JS. Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions. Angew Chem Int Ed Engl. 2011 Jun 20; 50(26):5938-42.View Related Profiles.

Panek, James
Porco, John

PMID: 21560214; DOI: 10.1002/anie.201101366;

Roche SP, Porco JA. Dearomatization strategies in the synthesis of complex natural products. Angew Chem Int Ed Engl. 2011 Apr 26; 50(18):4068-93. PMID: 21506209; PMCID: PMC4136767; DOI: 10.1002/anie.201006017;

Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6775-80.View Related Profiles.

Beeler, Aaron
Porco, John
Snyder, John
Schaus, Scott

PMID: 21498685; PMCID: PMC3084078; DOI: 10.1073/pnas.1017666108;

Germain AR, Bruggemeyer DM, Zhu J, Genet C, O'Brien P, Porco JA. Synthesis of the azaphilones (+)-sclerotiorin and (+)-8-O-methylsclerotiorinamine utilizing (+)-sparteine surrogates in copper-mediated oxidative dearomatization. J Org Chem. 2011 Apr 15; 76(8):2577-84. PMID: 21401026; PMCID: PMC3086581; DOI: 10.1021/jo102448n;

Xia B, Gerard B, Solano DM, Wan J, Jones G, Porco JA. ESIPT-mediated photocycloadditions of 3-hydroxyquinolinones: development of a fluorescence quenching assay for reaction screening. Org Lett. 2011 Mar 18; 13(6):1346-9. PMID: 21338078; PMCID: PMC3055927; DOI: 10.1021/ol200032f;

Sloman DL, Mitasev B, Scully SS, Beutler JA, Porco JA. Synthesis and biological evaluation of ABCD ring fragments of the kibdelones. Angew Chem Int Ed Engl. 2011 Mar 7; 50(11):2511-5. PMID: 21370327; PMCID: PMC3376643; DOI: 10.1002/anie.201007613;

Qin T, Johnson RP, Porco JA. Vinylogous addition of siloxyfurans to benzopyryliums: a concise approach to the tetrahydroxanthone natural products. J Am Chem Soc. 2011 Feb 16; 133(6):1714-7. PMID: 21265529; PMCID: PMC3099260; DOI: 10.1021/ja110698n;

Ebada SS, Lajkiewicz N, Porco JA, Li-Weber M, Proksch P. Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae). Prog Chem Org Nat Prod. 2011; 94:1-58. PMID: 21833837; PMCID: PMC4157394; DOI: 10.1007/978-3-7091-0748-5_1;

Zhang Q, Mitasev B, Qi J, Porco JA. Total synthesis of plukenetione A. J Am Chem Soc. 2010 Oct 13; 132(40):14212-5. PMID: 20843036; PMCID: PMC3014579; DOI: 10.1021/ja105784s;

Qi J, Beeler AB, Zhang Q, Porco JA. Catalytic enantioselective alkylative dearomatization-annulation: total synthesis and absolute configuration assignment of hyperibone K. J Am Chem Soc. 2010 Oct 6; 132(39):13642-4.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 20831187; PMCID: PMC2962984; DOI: 10.1021/ja1057828;

Roche SP, Cencic R, Pelletier J, Porco JA. Biomimetic photocycloaddition of 3-hydroxyflavones: synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation. Angew Chem Int Ed Engl. 2010 Sep 3; 49(37):6533-8. PMID: 20687060; PMCID: PMC3611328; DOI: 10.1002/anie.201003212;

Medeiros MR, Narayan RS, McDougal NT, Schaus SE, Porco JA. Skeletal diversity via cationic rearrangements of substituted dihydropyrans. Org Lett. 2010 Jul 16; 12(14):3222-5.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 20550144; PMCID: PMC2937281; DOI: 10.1021/ol101144k;

Marié JC, Xiong Y, Min GK, Yeager AR, Taniguchi T, Berova N, Schaus SE, Porco JA. Enantioselective synthesis of 3,4-chromanediones via asymmetric rearrangement of 3-allyloxyflavones. J Org Chem. 2010 Jul 2; 75(13):4584-90.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 20527786; PMCID: PMC2896495; DOI: 10.1021/jo100889c;

Goodell JR, Leng B, Snyder TK, Beeler AB, Porco JA. Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones. Synthesis (Stuttg). 2010 Jul 01; 2010(13):2254-2270.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 25132691

Cong H, Becker CF, Elliott SJ, Grinstaff MW, Porco JA. Silver nanoparticle-catalyzed Diels-Alder cycloadditions of 2'-hydroxychalcones. J Am Chem Soc. 2010 Jun 2; 132(21):7514-8.View Related Profiles.

Porco, John
Grinstaff, Mark
Elliott, Sean

PMID: 20443601; PMCID: PMC2882859; DOI: 10.1021/ja102482b;

Kinoshita H, Ingham OJ, Ong WW, Beeler AB, Porco JA. Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation. J Am Chem Soc. 2010 May 12; 132(18):6412-8.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 20394364; PMCID: PMC2881420; DOI: 10.1021/ja100346w;

Treece JL, Goodell JR, Vander Velde D, Porco JA, Aubé J. Reaction discovery using microfluidic-based multidimensional screening of polycyclic iminium ethers. J Org Chem. 2010 Mar 19; 75(6):2028-38. PMID: 20163127; PMCID: PMC2846649; DOI: 10.1021/jo100087h;

Liang B, Kalidindi S, Porco JA, Stephenson CR. Multicomponent reaction discovery: three-component synthesis of spirooxindoles. Org Lett. 2010 Feb 5; 12(3):572-5. PMID: 20050598; PMCID: PMC2814073; DOI: 10.1021/ol902764k;

Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD. A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization. Assay Drug Dev Technol. 2010 Feb; 8(1):96-105.View Related Profiles.

Beeler, Aaron
Porco, John
Snyder, John

PMID: 20035614; PMCID: PMC2971647; DOI: 10.1089/adt.2009.0217;

Cencic R, Carrier M, Trnkus A, Porco JA, Minden M, Pelletier J. Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells. Leuk Res. 2010 Apr; 34(4):535-41. PMID: 19726085; PMCID: PMC4117193; DOI: 10.1016/j.leukres.2009.07.043;

Goodell JR, McMullen JP, Zaborenko N, Maloney JR, Ho CX, Jensen KF, Porco JA, Beeler AB. Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds. J Org Chem. 2009 Aug 21; 74(16):6169-80.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 20560568; PMCID: PMC2976622; DOI: 10.1021/jo901073v;

Castaldi MP, Troast DM, Porco JA. Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations. Org Lett. 2009 Aug 6; 11(15):3362-5. PMID: 19719184; PMCID: PMC2739092; DOI: 10.1021/ol901201k;

Mitasev B, Porco JA. Manganese(III)-mediated transformations of phloroglucinols: a formal oxidative [4 + 2] cycloaddition leading to bicyclo[2.2.2]octadiones. Org Lett. 2009 Jun 4; 11(11):2285-8. PMID: 19415907; PMCID: PMC2740479; DOI: 10.1021/ol900590t;

Cencic R, Carrier M, Galicia-Vázquez G, Bordeleau ME, Sukarieh R, Bourdeau A, Brem B, Teodoro JG, Greger H, Tremblay ML, Porco JA, Pelletier J. Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PLoS One. 2009; 4(4):e5223. PMID: 19401772; PMCID: PMC2671147; DOI: 10.1371/journal.pone.0005223;

Han C, Rangarajan S, Voukides AC, Beeler AB, Johnson R, Porco JA. Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams. Org Lett. 2009 Jan 15; 11(2):413-6.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 19102683; PMCID: PMC2774802; DOI: 10.1021/ol802729f;

Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA. Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor. Angew Chem Int Ed Engl. 2009; 48(8):1494-7. PMID: 19140149; PMCID: PMC2747729; DOI: 10.1002/anie.200805486;

Troast DM, Yuan J, Porco JA. Studies Toward the Synthesis of (-)-Zampanolide: Preparation of the Macrocyclic Core. Adv Synth Catal. 2008 Aug 04; 350(11-12):1701-1711. PMID: 23543877

Bordeleau ME, Robert F, Gerard B, Lindqvist L, Chen SM, Wendel HG, Brem B, Greger H, Lowe SW, Porco JA, Pelletier J. Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J Clin Invest. 2008 Jul; 118(7):2651-60. PMID: 18551192; PMCID: PMC2423864; DOI: 10.1172/JCI34753;

Cong H, Ledbetter D, Rowe GT, Caradonna JP, Porco JA. Electron transfer-initiated Diels-Alder cycloadditions of 2'-hydroxychalcones. J Am Chem Soc. 2008 Jul 23; 130(29):9214-5.View Related Profiles.

Porco, John
Caradonna, John

PMID: 18576647; PMCID: PMC2635952; DOI: 10.1021/ja803094u;

Dong S, Zhu J, Porco JA. Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4 + 2] dimerization cascade. J Am Chem Soc. 2008 Mar 5; 130(9):2738-9. PMID: 18266375; PMCID: PMC2660372; DOI: 10.1021/ja711018z;

Williams AJ, Elyashberg ME, Blinov KA, Lankin DC, Martin GE, Reynolds WF, Porco JA, Singleton CA, Su S. Applying computer-assisted structure elucidation algorithms for the purpose of structure validation: revisiting the NMR assignments of hexacyclinol. J Nat Prod. 2008 Apr; 71(4):581-8. PMID: 18257535; DOI: 10.1021/np070557t;

Kesavan S, Panek JS, Porco JA. Preparation of alkylidene indane and related scaffolds and their further elaboration to novel chemotypes. Org Lett. 2007 Dec 6; 9(25):5203-6.View Related Profiles.

Panek, James
Porco, John

PMID: 17997565

Su S, Porco JA. 1,2-dihydroisoquinolines as templates for cascade reactions to access isoquinoline alkaloid frameworks. Org Lett. 2007 Nov 22; 9(24):4983-6. PMID: 17958365

Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6836-40. PMID: 17964153; PMCID: PMC2169518

Qi J, Porco JA. Rapid access to polyprenylated phloroglucinols via alkylative dearomatization-annulation: total synthesis of (+/-)-clusianone(1). J Am Chem Soc. 2007 Oct 24; 129(42):12682-3. PMID: 17902679; PMCID: PMC2660373

Dandapani S, Duduta M, Panek JS, Porco JA. Skeletal diversity through radical cyclization of tetrahydropyridine scaffolds. Org Lett. 2007 Sep 13; 9(19):3849-52.View Related Profiles.

Panek, James
Porco, John

PMID: 17713919

Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA, Schreiber SL, Chung RT. Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrob Agents Chemother. 2007 Oct; 51(10):3756-9.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 17682098; PMCID: PMC2043288

Su S, Porco JA. Synthesis of pyrrolo-isoquinolines related to the lamellarins using silver-catalyzed cycloisomerization/dipolar cycloaddition. J Am Chem Soc. 2007 Jun 27; 129(25):7744-5. PMID: 17539647

Comer E, Rohan E, Deng L, Porco JA. An approach to skeletal diversity using functional group pairing of multifunctional scaffolds. Org Lett. 2007 May 24; 9(11):2123-6. PMID: 17472394

Porco JA. Organic chemistry: synthesis undressed. Nature. 2007 Mar 22; 446(7134):383-5. PMID: 17377569

Chen Y, Porco JA, Panek JS. Stereochemical and skeletal diversity employing pipecolate ester scaffolds. Org Lett. 2007 Apr 12; 9(8):1529-32.View Related Profiles.

Panek, James
Porco, John

PMID: 17367153

Han C, Porco JA. Synthesis of carbamates and ureas using Zr(IV)-catalyzed exchange processes. Org Lett. 2007 Apr 12; 9(8):1517-20. PMID: 17358074

Beeler AB, Su S, Singleton CA, Porco JA. Discovery of chemical reactions through multidimensional screening. J Am Chem Soc. 2007 Feb 7; 129(5):1413-9.View Related Profiles.

Beeler, Aaron
Porco, John

PMID: 17263426

Zhou Y, Porco JA, Snyder JK. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations. Org Lett. 2007 Feb 1; 9(3):393-6.View Related Profiles.

Porco, John
Snyder, John

PMID: 17249770

Ong WW, Beeler AB, Kesavan S, Panek JS, Porco JA. Nucleophilic addition to N-phosphinylimines by rare-earth-metal triflate/trifluoroacetic anhydride activation. Angew Chem Int Ed Engl. 2007; 46(39):7470-2.View Related Profiles.

Beeler, Aaron
Panek, James
Porco, John

PMID: 17722135

Gerard B, Cencic R, Pelletier J, Porco JA. Enantioselective synthesis of the complex rocaglate (-)-silvestrol. Angew Chem Int Ed Engl. 2007; 46(41):7831-4. PMID: 17806093

Lei X, Porco JA. Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1. J Am Chem Soc. 2006 Nov 22; 128(46):14790-1. PMID: 17105273

Dandapani S, Lan P, Beeler AB, Beischel S, Abbas A, Roth BL, Porco JA, Panek JS. Convergent synthesis of complex diketopiperazines derived from pipecolic acid scaffolds and parallel screening against GPCR targets. J Org Chem. 2006 Nov 10; 71(23):8934-45.View Related Profiles.

Beeler, Aaron
Panek, James
Porco, John

PMID: 17081025

Yeager AR, Min GK, Porco JA, Schaus SE. Exploring skeletal diversity via ring contraction of glycal-derived scaffolds. Org Lett. 2006 Oct 26; 8(22):5065-8.View Related Profiles.

Porco, John
Schaus, Scott

PMID: 17048844

Zhu J, Porco JA. Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products. Org Lett. 2006 Oct 26; 8(22):5169-71. PMID: 17048870

Porco JA, Su S, Lei X, Bardhan S, Rychnovsky SD. Total synthesis and structure assignment of (+)-hexacyclinol. Angew Chem Int Ed Engl. 2006 Sep 4; 45(35):5790-2. PMID: 16871643

Kleinke AS, Li C, Rabasso N, Porco JA. Total synthesis of the interleukin-1beta converting enzyme inhibitor EI-1941-2 using tandem oxa-electrocyclization/oxidation1. Org Lett. 2006 Jun 22; 8(13):2847-50. PMID: 16774272

Gerard B, Sangji S, O'Leary DJ, Porco JA. Enantioselective photocycloaddition mediated by chiral Brønsted acids: asymmetric synthesis of the rocaglamides. J Am Chem Soc. 2006 Jun 21; 128(24):7754-5. PMID: 16771486

Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab. 2006 Jun; 3(6):417-27. PMID: 16753577

Bardhan S, Schmitt DC, Porco JA. Total synthesis and stereochemical assignment of the spiroisoxazoline natural product (+)-calafianin. Org Lett. 2006 Mar 2; 8(5):927-30. PMID: 16494476

Helton ME, Maiti D, Zakharov LN, Rheingold AL, Porco JA, Karlin KD. A mu-eta2:eta2-disulfide dicopper(II) complex from reaction of S8 with a copper(I) precursor: reactivity of the bound disulfur moiety. Angew Chem Int Ed Engl. 2006 Feb 6; 45(7):1138-41. PMID: 16385608

Zaarur N, Gabai VL, Porco JA, Calderwood S, Sherman MY. Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res. 2006 Feb 1; 66(3):1783-91.View Related Profiles.

Porco, John
Sherman, Michael
Zaarur, Nava
Gabai, Vladimir

PMID: 16452239

Liang MC, Bardhan S, Pace EA, Rosman D, Beutler JA, Porco JA, Gilmore TD. Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity. Biochem Pharmacol. 2006 Feb 28; 71(5):634-45.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 16360644

Liang MC, Bardhan S, Porco JA, Gilmore TD. The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line. Cancer Lett. 2006 Sep 8; 241(1):69-78.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 16289774

Kesavan S, Su Q, Shao J, Porco JA, Panek JS. Enantioselective synthesis of linear polypropionate arrays using anthracene-tagged organosilanes. Org Lett. 2005 Sep 29; 7(20):4435-8.View Related Profiles.

Panek, James
Porco, John

PMID: 16178552

Beeler AB, Acquilano DE, Su Q, Yan F, Roth BL, Panek JS, Porco JA. Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters. J Comb Chem. 2005 Sep-Oct; 7(5):673-81.View Related Profiles.

Beeler, Aaron
Panek, James
Porco, John

PMID: 16153061

Lei X, Zaarur N, Sherman MY, Porco JA. Stereocontrolled synthesis of a complex library via elaboration of angular epoxyquinol scaffolds. J Org Chem. 2005 Aug 5; 70(16):6474-83.View Related Profiles.

Porco, John
Sherman, Michael
Zaarur, Nava

PMID: 16050712

Li C, Porco JA. Synthesis of epoxyquinol A and related molecules: probing chemical reactivity of epoxyquinol dimers and 2H-pyran precursors. J Org Chem. 2005 Jul 22; 70(15):6053-65. PMID: 16018703

Han C, Lee JP, Lobkovsky E, Porco JA. Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes. J Am Chem Soc. 2005 Jul 20; 127(28):10039-44. PMID: 16011366; PMCID: PMC1475744

Zhu J, Grigoriadis NP, Lee JP, Porco JA. Synthesis of the azaphilones using copper-mediated enantioselective oxidative dearomatization. J Am Chem Soc. 2005 Jul 6; 127(26):9342-3. PMID: 15984841

Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Org Lett. 2005 Jun 23; 7(13):2751-4.View Related Profiles.

Beeler, Aaron
Panek, James
Porco, John
Snyder, John
Schaus, Scott

PMID: 15957938

Beeler AB, Schaus SE, Porco JA. Chemical library synthesis using convergent approaches. Curr Opin Chem Biol. 2005 Jun; 9(3):277-84.View Related Profiles.

Beeler, Aaron
Porco, John
Schaus, Scott

PMID: 15939329

Wang X, Porco JA. Synthesis of the tetracyclic core of the tetrapetalones through transannular oxidative [4+3] cyclization. Angew Chem Int Ed Engl. 2005 May 13; 44(20):3067-71. PMID: 15832389

Shen R, Inoue T, Forgac M, Porco JA. Synthesis of photoactivatable acyclic analogues of the lobatamides. J Org Chem. 2005 Apr 29; 70(9):3686-92. PMID: 15845008

Gerard B, Jones Ii G, Porco JA. A biomimetic approach to the rocaglamides employing photogeneration of oxidopyryliums derived from 3-hydroxyflavones. J Am Chem Soc. 2004 Oct 27; 126(42):13620-1. PMID: 15493911

Wang X, Bowman EJ, Bowman BJ, Porco JA. Total synthesis of the salicylate enamide macrolide oximidine III: application of relay ring-closing metathesis. Angew Chem Int Ed Engl. 2004 Jul 5; 43(27):3601-5. PMID: 15293258

Lei X, Porco JA. Synthesis of a polymer-supported anthracene and its application as a dienophile scavenger. Org Lett. 2004 Mar 4; 6(5):795-8. PMID: 14986977

Zhu J, Germain AR, Porco JA. Synthesis of azaphilones and related molecules by employing cycloisomerization of o-alkynylbenzaldehydes. Angew Chem Int Ed Engl. 2004 Feb 27; 43(10):1239-43. PMID: 14991787

Li C, Porco JA. Synthesis of the epoxyquinol dimer RKB-3564 D: utilization of an alkoxysilanol to promote [4 + 4] dimerization. J Am Chem Soc. 2004 Feb 11; 126(5):1310-1. PMID: 14759167

Han C, Shen R, Su S, Porco JA. Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801. Org Lett. 2004 Jan 8; 6(1):27-30. PMID: 14703342

Lan P, Berta D, Porco JA, South MS, Parlow JJ. Polymer-assisted solution-phase (PASP) Suzuki couplings employing an anthracene-tagged palladium catalyst. J Org Chem. 2003 Dec 12; 68(25):9678-86. PMID: 14656094

Lei X, Johnson RP, Porco JA. Total synthesis of the ubiquitin-activating enzyme inhibitor (+)-panepophenanthrin. Angew Chem Int Ed Engl. 2003 Aug 25; 42(33):3913-7. PMID: 12949867

Shen R, Lin CT, Bowman EJ, Bowman BJ, Porco JA. Lobatamide C: total synthesis, stereochemical assignment, preparation of simplified analogues, and V-ATPase inhibition studies. J Am Chem Soc. 2003 Jul 2; 125(26):7889-901. PMID: 12823009

Liang MC, Bardhan S, Li C, Pace EA, Porco JA, Gilmore TD. Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase. Mol Pharmacol. 2003 Jul; 64(1):123-31.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 12815168

Su Q, Beeler AB, Lobkovsky E, Porco JA, Panek JS. Stereochemical diversity through cyclodimerization: synthesis of polyketide-like macrodiolides. Org Lett. 2003 Jun 12; 5(12):2149-52.View Related Profiles.

Beeler, Aaron
Panek, James
Porco, John

PMID: 12790551

Wang X, Porco JA. Total synthesis of the salicylate enamide macrolide oximidine II. J Am Chem Soc. 2003 May 21; 125(20):6040-1. PMID: 12785818

Li C, Johnson RP, Porco JA. Total synthesis of the quinone epoxide dimer (+)-torreyanic acid: application of a biomimetic oxidation/electrocyclization/Diels-Alder dimerization cascade. J Am Chem Soc. 2003 Apr 30; 125(17):5095-106. PMID: 12708860

Li C, Bardhan S, Pace EA, Liang MC, Gilmore TD, Porco JA. Angiogenesis inhibitor epoxyquinol a: total synthesis and inhibition of transcription factor NF-kappaB. Org Lett. 2002 Sep 19; 4(19):3267-70.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 12227765

Shen R, Lin CT, Bowman EJ, Bowman BJ, Porco JA. Synthesis and V-ATPase inhibition of simplified lobatamide analogues. Org Lett. 2002 Sep 5; 4(18):3103-6. PMID: 12201727

Shen R, Lin CT, Porco JA. Total synthesis and stereochemical assignment of the salicylate antitumor macrolide lobatamide C(1). J Am Chem Soc. 2002 May 22; 124(20):5650-1. PMID: 12010033

Troast DM, Porco JA. Studies toward the synthesis of (-)-zampanolide: preparation of N-acyl hemiaminal model systems. Org Lett. 2002 Mar 21; 4(6):991-4. PMID: 11893204

Kulkarni BA, Roth GP, Lobkovsky E, Porco JA. Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold. J Comb Chem. 2002 Jan-Feb; 4(1):56-72. PMID: 11831883

Wang X, Porco JA. Modification of C-terminal peptides to form peptide enamides: synthesis of chondriamides A and C. J Org Chem. 2001 Nov 30; 66(24):8215-21. PMID: 11722228

Li C, Pace EA, Liang MC, Lobkovsky E, Gilmore TD, Porco JA. Total synthesis of the NF-kappa B inhibitor (-)-cycloepoxydon: utilization of tartrate-mediated nucleophilic epoxidation. J Am Chem Soc. 2001 Nov 14; 123(45):11308-9.View Related Profiles.

Porco, John
Gilmore, Thomas

PMID: 11697981

Hu Y, Li C, Kulkarni BA, Strobel G, Lobkovsky E, Torczynski RM, Porco JA. Exploring chemical diversity of epoxyquinoid natural products: synthesis and biological activity of (-)-jesterone and related molecules. Org Lett. 2001 May 31; 3(11):1649-52. PMID: 11405677

Wang X, Parlow JJ, Porco JA. Parallel synthesis and purification using anthracene-tagged substrates. Org Lett. 2000 Nov 2; 2(22):3509-12. PMID: 11082021

Porco JA. Organic synthesis using chemical tags: the third Leg of parallel synthesis. Comb Chem High Throughput Screen. 2000 Apr; 3(2):93-102. PMID: 10788579

Porco JA, Labadie JW. Polymer supports for streamlined organic synthesis. Biotechnol Bioeng. 2000; 71(1):1-2. PMID: 10629529

Yun YK, Leung SS, Porco JA. Streamlined synthesis of substituted 2-aminothiazoles using tandem precipitative and polymer-assisted reactions. Biotechnol Bioeng. 2000; 71(1):9-18. PMID: 10629531

Hu Y, Baudart S, Porco JA. Parallel Synthesis of 1,2,3-Thiadiazoles Employing a "Catch and Release" Strategy. J Org Chem. 1999 Feb 05; 64(3):1049-1051. PMID: 11674188

Deegan TL, Nitz TJ, Cebzanov D, Pufko DE, Porco JA. Parallel synthesis of 1,2,4-oxadiazoles using CDI activation. Bioorg Med Chem Lett. 1999 Jan 18; 9(2):209-12. PMID: 10021930

Porco JA, Deegan T, Devonport W, Gooding OW, Heisler K, Labadie JW, Newcomb B, Nguyen C, van Eikeren P, Wong J, Wright P. Automated chemical synthesis: from resins to instruments. Mol Divers. 1997; 2(4):197-206. PMID: 9249755

Schreiber SL, Kelly SE, Porco JA, Sammakia T, Suh EM. Structural and synthetic studies of the spore germination autoinhibitor, gloeosporone. J Am Chem Soc. 1988 Aug 1; 110(18):6210-8. PMID: 22148801; DOI: 10.1021/ja00226a041;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 193 publications over 24 distinct years, with a maximum of 19 publications in 2011

Bar chart showing 193 publications over 24 distinct years, with a maximum of 19 publications in 2011

Year	Publications
1988	1
1997	1
1999	2
2000	4
2001	3
2002	5
2003	7
2004	6
2005	12
2006	11
2007	15
2008	5
2009	7
2010	11
2011	19
2012	14
2013	8
2014	13
2015	6
2016	9
2017	4
2018	9
2019	17
2020	4

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