Keywords
Last Name

Michael Sherman, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-5971
ORCID ORCID Icon0000-0003-3345-073X
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
I. Research in my lab has focused on understanding the molecular mechanisms underlying the central role of the heat shock protein Hsp72 in cancer. In cancer cells Hsp72 is often expressed at very high levels, and its expression correlates with the aggressiveness of tumors. Recently we have found that Hsp72 regulates early stages of tumorigenesis. Indeed, Hsp72 can control signaling pathways initiated by major oncogenes, resulting in avoiding growth inhibition and facilitating cell proliferation and transformation.

Our research addresses several questions:

(1) How Hsp72 keeps the p53 pathway activated by PIK3CA oncogene under control?

(2) How Hsp72 prevents cell senescence activated by Her2 oncogene.

II. In a distinct project we study a process of aggregation of abnormal polypeptides. When chaperone and protein degradation machineries fail to handle abnormal proteins, they aggregate and cause cell toxicity, which may give rise to various neurological disorders. As the last line of defense, a special machinery has evolved that transports these toxic aggregates to a centrosome location via microtubules, which leads to relieve of toxicity. The resulting non-toxic single large aggregate is called aggresome. Previously we have established a yeast model to study aggregation and toxicity of the disease-causing polypeptides with expanded polyglutamine domain. Now, using both yeast and mammalian systems, we are dissecting the pathway of aggresome formation.

Our current research within this project uses genetics and biochemical approaches to addresses the following questions:

(1) What cellular components are involved in aggresome formation?

(2) What signaling pathways control aggresome formation?

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 Jan 15; 26(2):305-319. PMID: 28065882.
    View in: PubMed
  2. Gabai VL, Yaglom JA, Wang Y, Meng L, Shao H, Kim G, Colvin T, Gestwicki J, Sherman MY. Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells. Cancer Res. 2016 Oct 15; 76(20):5926-5932. PMID: 27503927.
    View in: PubMed
  3. Lee do H, Sherman MY, Goldberg AL. The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins. Biochem Biophys Res Commun. 2016 Jun 17; 475(1):100-6. PMID: 27178214.
    View in: PubMed
  4. Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY. RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. EMBO J. 2015 Sep 14; 34(18):2363-82. PMID: 26303906.
    View in: PubMed
  5. Sabbieti MG, Agas D, Capitani M, Marchetti L, Concetti A, Vullo C, Catone G, Gabai V, Shifrin V, Sherman MY, Shneider A, Venanzi FM. Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent. Oncotarget. 2015 Feb 28; 6(6):3590-9. PMID: 25668818.
    View in: PubMed
  6. Gong J, Weng D, Eguchi T, Murshid A, Sherman MY, Song B, Calderwood SK. Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis. Oncogene. 2015 Oct; 34(43):5460-71. PMID: 25659585.
    View in: PubMed
  7. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. PMID: 25564440.
    View in: PubMed
  8. Gabai V, Venanzi FM, Bagashova E, Rud O, Mariotti F, Vullo C, Catone G, Sherman MY, Concetti A, Chursov A, Latanova A, Shcherbinina V, Shifrin V, Shneider A. Pilot study of p62 DNA vaccine in dogs with mammary tumors. Oncotarget. 2014 Dec 30; 5(24):12803-10. PMID: 25296974.
    View in: PubMed
  9. Sherman MY, Gabai VL. Hsp70 in cancer: back to the future. Oncogene. 2015 Aug 6; 34(32):4153-61. PMID: 25347739.
    View in: PubMed
  10. Yaglom JA, McFarland C, Mirny L, Sherman MY. Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer. Oncotarget. 2014 Sep 30; 5(18):8367-78. PMID: 25252808.
    View in: PubMed
  11. Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, Takayama S, Sherman MY. Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Res. 2014 Sep 1; 74(17):4731-40. PMID: 24994713.
    View in: PubMed
  12. Colvin TA, Gabai VL, Sherman MY. Proteotoxicity is not the reason for the dependence of cancer cells on the major chaperone Hsp70. Cell Cycle. 2014; 13(14):2306-10. PMID: 24911412.
    View in: PubMed
  13. Zaarur N, Meriin AB, Bejarano E, Xu X, Gabai VL, Cuervo AM, Sherman MY. Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport. Mol Cell Biol. 2014 Apr; 34(7):1336-48. PMID: 24469403.
    View in: PubMed
  14. Sherman MY, Qian SB. Less is more: improving proteostasis by translation slow down. Trends Biochem Sci. 2013 Dec; 38(12):585-91. PMID: 24126073.
    View in: PubMed
  15. Venanzi F, Shifrin V, Sherman M, Gabai V, Kiselev O, Komissarov A, Grudinin M, Shartukova M, Romanovskaya-Romanko EA, Kudryavets Y, Bezdenezhnykh N, Lykhova O, Semesyuk N, Concetti A, Tsyb A, Filimonova M, Makarchuk V, Yakubovsky R, Chursov A, Shcherbinina V, Shneider A. Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector. Oncotarget. 2013 Oct; 4(10):1829-35. PMID: 24121124.
    View in: PubMed
  16. Bergholz J, Zhang Y, Wu J, Meng L, Walsh EM, Rai A, Sherman MY, Xiao ZX. ?Np63a regulates Erk signaling via MKP3 to inhibit cancer metastasis. Oncogene. 2014 Jan 9; 33(2):212-24. PMID: 23246965.
    View in: PubMed
  17. Meriin AB, Mense M, Colbert JD, Liang F, Bihler H, Zaarur N, Rock KL, Sherman MY. A novel approach to recovery of function of mutant proteins by slowing down translation. J Biol Chem. 2012 Oct 5; 287(41):34264-72. PMID: 22902621.
    View in: PubMed
  18. Kim G, Meriin AB, Gabai VL, Christians E, Benjamin I, Wilson A, Wolozin B, Sherman MY. The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell. 2012 Aug; 11(4):617-27. PMID: 22510478.
    View in: PubMed
  19. Gong H, Romanova NV, Allen KD, Chandramowlishwaran P, Gokhale K, Newnam GP, Mieczkowski P, Sherman MY, Chernoff YO. Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast. PLoS Genet. 2012; 8(4):e1002634. PMID: 22536159.
    View in: PubMed
  20. Meriin AB, Zaarur N, Sherman MY. Association of translation factor eEF1A with defective ribosomal products generates a signal for aggresome formation. J Cell Sci. 2012 Jun 1; 125(Pt 11):2665-74. PMID: 22357952.
    View in: PubMed
  21. Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY. Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol Cell Biol. 2012 Mar; 32(5):929-40. PMID: 22215620.
    View in: PubMed
  22. Wong E, Bejarano E, Rakshit M, Lee K, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM. Molecular determinants of selective clearance of protein inclusions by autophagy. Nat Commun. 2012; 3:1240. PMID: 23212369.
    View in: PubMed
  23. Sherman MY, Meng L, Stampfer M, Gabai VL, Yaglom JA. Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells. Aging Cell. 2011 Dec; 10(6):949-61. PMID: 21824272.
    View in: PubMed
  24. Sherman MY. Proteotoxic stress targeted therapy (PSTT). Oncotarget. 2011 May; 2(5):356-7. PMID: 21636878.
    View in: PubMed
  25. Walpita P, Barr J, Sherman M, Basler CF, Wang L. Vaccine potential of Nipah virus-like particles. PLoS One. 2011; 6(4):e18437. PMID: 21494680.
    View in: PubMed
  26. Meng L, Hunt C, Yaglom JA, Gabai VL, Sherman MY. Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis. Oncogene. 2011 Jun 23; 30(25):2836-45. PMID: 21297664.
    View in: PubMed
  27. Wang Z, Gall JM, Bonegio RG, Havasi A, Hunt CR, Sherman MY, Schwartz JH, Borkan SC. Induction of heat shock protein 70 inhibits ischemic renal injury. Kidney Int. 2011 Apr; 79(8):861-70. PMID: 21270764.
    View in: PubMed
  28. Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderweyde T, Vanderwyde T, Citro A, Mehta T, Zaarur N, McKee A, Bowser R, Sherman M, Petrucelli L, Wolozin B. Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. PLoS One. 2010; 5(10):e13250. PMID: 20948999.
    View in: PubMed
  29. Meriin AB, Wang Y, Sherman MY. Isolation of aggresomes and other large aggregates. Curr Protoc Cell Biol. 2010 Sep; Chapter 3:Unit 3.38.1-9. PMID: 20853343.
    View in: PubMed
  30. Meng L, Gabai VL, Sherman MY. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. Oncogene. 2010 Sep 16; 29(37):5204-13. PMID: 20622894.
    View in: PubMed
  31. Sherman M. Major heat shock protein Hsp72 controls oncogene-induced senescence. Ann N Y Acad Sci. 2010 Jun; 1197:152-7. PMID: 20536844.
    View in: PubMed
  32. Gabai VL, Sherman MY, Yaglom JA. HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling. Oncogene. 2010 Apr 1; 29(13):1952-62. PMID: 20062073.
    View in: PubMed
  33. Gabai VL, Yaglom JA, Waldman T, Sherman MY. Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. Mol Cell Biol. 2009 Jan; 29(2):559-69. PMID: 19001088.
    View in: PubMed
  34. Wang Y, Meriin AB, Zaarur N, Romanova NV, Chernoff YO, Costello CE, Sherman MY. Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery. FASEB J. 2009 Feb; 23(2):451-63. PMID: 18854435.
    View in: PubMed
  35. Zaarur N, Meriin AB, Gabai VL, Sherman MY. Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin 1. J Biol Chem. 2008 Oct 10; 283(41):27575-84. PMID: 18635553.
    View in: PubMed
  36. Dinov ID, Rubin D, Lorensen W, Dugan J, Ma J, Murphy S, Kirschner B, Bug W, Sherman M, Floratos A, Kennedy D, Jagadish HV, Schmidt J, Athey B, Califano A, Musen M, Altman R, Kikinis R, Kohane I, Delp S, Parker DS, Toga AW. iTools: a framework for classification, categorization and integration of computational biology resources. PLoS One. 2008; 3(5):e2265. PMID: 18509477.
    View in: PubMed
  37. Ilyinskii PO, Thoidis G, Sherman MY, Shneider A. Adjuvant potential of aggregate-forming polyglutamine domains. Vaccine. 2008 Jun 19; 26(26):3223-6. PMID: 18467011.
    View in: PubMed
  38. Gabai VL, O'Callaghan-Sunol C, Meng L, Sherman MY, Yaglom J. Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses. Cancer Res. 2008 Mar 15; 68(6):1834-42. PMID: 18339864.
    View in: PubMed
  39. Park MA, Yacoub A, Rahmani M, Zhang G, Hart L, Hagan MP, Calderwood SK, Sherman MY, Koumenis C, Spiegel S, Chen CS, Graf M, Curiel DT, Fisher PB, Grant S, Dent P. OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells. Mol Pharmacol. 2008 Apr; 73(4):1168-84. PMID: 18182481.
    View in: PubMed
  40. O'Callaghan-Sunol C, Gabai VL, Sherman MY. Hsp27 modulates p53 signaling and suppresses cellular senescence. Cancer Res. 2007 Dec 15; 67(24):11779-88. PMID: 18089808.
    View in: PubMed
  41. Sherman M, Multhoff G. Heat shock proteins in cancer. Ann N Y Acad Sci. 2007 Oct; 1113:192-201. PMID: 17978282.
    View in: PubMed
  42. Sherman M. Universal genome in the origin of metazoa: thoughts about evolution. Cell Cycle. 2007 Aug 1; 6(15):1873-7. PMID: 17660714.
    View in: PubMed
  43. Sherman MY, Sherman M, Gabai V, O'Callaghan C, Yaglom J. Molecular chaperones regulate p53 and suppress senescence programs. FEBS Lett. 2007 Jul 31; 581(19):3711-5. PMID: 17555746.
    View in: PubMed
  44. Wang Y, Meriin AB, Costello CE, Sherman MY. Characterization of proteins associated with polyglutamine aggregates: a novel approach towards isolation of aggregates from protein conformation disorders. Prion. 2007 Apr-Jun; 1(2):128-35. PMID: 19164926.
    View in: PubMed
  45. Meriin AB, Zhang X, Alexandrov IM, Salnikova AB, Ter-Avanesian MD, Chernoff YO, Sherman MY. Endocytosis machinery is involved in aggregation of proteins with expanded polyglutamine domains. FASEB J. 2007 Jun; 21(8):1915-25. PMID: 17341688.
    View in: PubMed
  46. Yaglom JA, Gabai VL, Sherman MY. High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways. Cancer Res. 2007 Mar 1; 67(5):2373-81. PMID: 17332370.
    View in: PubMed
  47. O'Callaghan-Sunol C, Sherman MY. Heat shock transcription factor (HSF1) plays a critical role in cell migration via maintaining MAP kinase signaling. Cell Cycle. 2006 Jul; 5(13):1431-7. PMID: 16855393.
    View in: PubMed
  48. Sherman MY, Gabai VL. Multiple thermometers in mammalian cells: why do cells from homeothermic organisms need to measure temperature? Sci STKE. 2006 Mar 28; 2006(328):pe16. PMID: 16569818.
    View in: PubMed
  49. Zaarur N, Gabai VL, Porco JA, Calderwood S, Sherman MY. Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res. 2006 Feb 1; 66(3):1783-91. PMID: 16452239.
    View in: PubMed
  50. Ganusova EE, Ozolins LN, Bhagat S, Newnam GP, Wegrzyn RD, Sherman MY, Chernoff YO. Modulation of prion formation, aggregation, and toxicity by the actin cytoskeleton in yeast. Mol Cell Biol. 2006 Jan; 26(2):617-29. PMID: 16382152.
    View in: PubMed
  51. Lei X, Zaarur N, Sherman MY, Porco JA. Stereocontrolled synthesis of a complex library via elaboration of angular epoxyquinol scaffolds. J Org Chem. 2005 Aug 5; 70(16):6474-83. PMID: 16050712.
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  52. Meriin AB, Sherman MY. Role of molecular chaperones in neurodegenerative disorders. Int J Hyperthermia. 2005 Aug; 21(5):403-19. PMID: 16048838.
    View in: PubMed
  53. Gabai VL, Budagova KR, Sherman MY. Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents. Oncogene. 2005 May 5; 24(20):3328-38. PMID: 15735699.
    View in: PubMed
  54. Gokhale KC, Newnam GP, Sherman MY, Chernoff YO. Modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model. J Biol Chem. 2005 Jun 17; 280(24):22809-18. PMID: 15824100.
    View in: PubMed
  55. Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG. A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):892-7. PMID: 15642944.
    View in: PubMed
  56. Sherman MY. Yeast prions: protein aggregation is not enough. PLoS Biol. 2004 Apr; 2(4):E125. PMID: 15094820.
    View in: PubMed
  57. Meriin AB, Zhang X, Miliaras NB, Kazantsev A, Chernoff YO, McCaffery JM, Wendland B, Sherman MY. Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis. Mol Cell Biol. 2003 Nov; 23(21):7554-65. PMID: 14560003.
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  58. Yaglom JA, Ekhterae D, Gabai VL, Sherman MY. Regulation of necrosis of H9c2 myogenic cells upon transient energy deprivation. Rapid deenergization of mitochondria precedes necrosis and is controlled by reactive oxygen species, stress kinase JNK, HSP72 and ARC. J Biol Chem. 2003 Dec 12; 278(50):50483-96. PMID: 14523009.
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  59. Yaglom J, O'Callaghan-Sunol C, Gabai V, Sherman MY. Inactivation of dual-specificity phosphatases is involved in the regulation of extracellular signal-regulated kinases by heat shock and hsp72. Mol Cell Biol. 2003 Jun; 23(11):3813-24. PMID: 12748284.
    View in: PubMed
  60. Sherman MY, Muchowski PJ. Making yeast tremble: yeast models as tools to study neurodegenerative disorders. Neuromolecular Med. 2003; 4(1-2):133-46. PMID: 14528057.
    View in: PubMed
  61. Mattson MP, Sherman M. Perturbed signal transduction in neurodegenerative disorders involving aberrant protein aggregation. Neuromolecular Med. 2003; 4(1-2):109-32. PMID: 14528056.
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  62. Meriin AB, Zhang X, He X, Newnam GP, Chernoff YO, Sherman MY. Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1. J Cell Biol. 2002 Jun 10; 157(6):997-1004. PMID: 12058016.
    View in: PubMed
  63. Gabai VL, Mabuchi K, Mosser DD, Sherman MY. Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Mol Cell Biol. 2002 May; 22(10):3415-24. PMID: 11971973.
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  64. Lechpammer S, Asea A, Mallick R, Zhong R, Sherman MY, Calderwood SK. Development of an XTT tetrazolium salt-based assay for detection of specific hyperthermia sensitizers in a high-flux screening programme. Int J Hyperthermia. 2002 May-Jun; 18(3):203-15. PMID: 12061330.
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  65. Gabai VL, Sherman MY. Invited review: Interplay between molecular chaperones and signaling pathways in survival of heat shock. J Appl Physiol (1985). 2002 Apr; 92(4):1743-8. PMID: 11896044.
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  66. Meriin AB, Mabuchi K, Gabai VL, Yaglom JA, Kazantsev A, Sherman MY. Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1. J Cell Biol. 2001 May 14; 153(4):851-64. PMID: 11352944.
    View in: PubMed
  67. Sherman MY, Goldberg AL. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron. 2001 Jan; 29(1):15-32. PMID: 11182078.
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  68. Gabai VL, Meriin AB, Yaglom JA, Wei JY, Mosser DD, Sherman MY. Suppression of stress kinase JNK is involved in HSP72-mediated protection of myogenic cells from transient energy deprivation. HSP72 alleviates the stewss-induced inhibition of JNK dephosphorylation. J Biol Chem. 2000 Dec 1; 275(48):38088-94. PMID: 10978340.
    View in: PubMed
  69. Huang HC, Sherman MY, Kandror O, Goldberg AL. The molecular chaperone DnaJ is required for the degradation of a soluble abnormal protein in Escherichia coli. J Biol Chem. 2001 Feb 9; 276(6):3920-8. PMID: 11062236.
    View in: PubMed
  70. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol. 2000 Oct; 20(19):7146-59. PMID: 10982831.
    View in: PubMed
  71. Gabai VL, Yaglom JA, Volloch V, Meriin AB, Force T, Koutroumanis M, Massie B, Mosser DD, Sherman MY. Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol Cell Biol. 2000 Sep; 20(18):6826-36. PMID: 10958679.
    View in: PubMed
  72. Volloch V, Gabai VL, Rits S, Force T, Sherman MY. HSP72 can protect cells from heat-induced apoptosis by accelerating the inactivation of stress kinase JNK. Cell Stress Chaperones. 2000 Apr; 5(2):139-47. PMID: 11147965.
    View in: PubMed
  73. Volloch V, Gabai VL, Rits S, Sherman MY. ATPase activity of the heat shock protein hsp72 is dispensable for its effects on dephosphorylation of stress kinase JNK and on heat-induced apoptosis. FEBS Lett. 1999 Nov 12; 461(1-2):73-6. PMID: 10561499.
    View in: PubMed
  74. Yaglom JA, Gabai VL, Meriin AB, Mosser DD, Sherman MY. The function of HSP72 in suppression of c-Jun N-terminal kinase activation can be dissociated from its role in prevention of protein damage. J Biol Chem. 1999 Jul 16; 274(29):20223-8. PMID: 10400639.
    View in: PubMed
  75. Volloch VZ, Sherman MY. Oncogenic potential of Hsp72. Oncogene. 1999 Jun 17; 18(24):3648-51. PMID: 10380887.
    View in: PubMed
  76. Meriin AB, Yaglom JA, Gabai VL, Zon L, Ganiatsas S, Mosser DD, Zon L, Sherman MY. Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol Cell Biol. 1999 Apr; 19(4):2547-55. PMID: 10082520.
    View in: PubMed
  77. Volloch V, Mosser DD, Massie B, Sherman MY. Reduced thermotolerance in aged cells results from a loss of an hsp72-mediated control of JNK signaling pathway. Cell Stress Chaperones. 1998 Dec; 3(4):265-71. PMID: 9880239.
    View in: PubMed
  78. Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 1998 Oct 30; 438(1-2):1-4. PMID: 9821948.
    View in: PubMed
  79. Meriin AB, Gabai VL, Yaglom J, Shifrin VI, Sherman MY. Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis. J Biol Chem. 1998 Mar 13; 273(11):6373-9. PMID: 9497367.
    View in: PubMed
  80. Gabai VL, Meriin AB, Mosser DD, Caron AW, Rits S, Shifrin VI, Sherman MY. Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance. J Biol Chem. 1997 Jul 18; 272(29):18033-7. PMID: 9218432.
    View in: PubMed
  81. Lee DH, Sherman MY, Goldberg AL. Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Sep; 16(9):4773-81. PMID: 8756635.
    View in: PubMed
  82. Yaglom JA, Goldberg AL, Finley D, Sherman MY. The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation. Mol Cell Biol. 1996 Jul; 16(7):3679-84. PMID: 8668184.
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  83. Sherman MY, Goldberg AL. Involvement of molecular chaperones in intracellular protein breakdown. EXS. 1996; 77:57-78. PMID: 8856969.
    View in: PubMed
  84. Nigam SK, Goldberg AL, Ho S, Rohde MF, Bush KT, Sherman MYu. A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily. J Biol Chem. 1994 Jan 21; 269(3):1744-9. PMID: 8294423.
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  85. Sherman MY, Goldberg AL. Heat shock of Escherichia coli increases binding of dnaK (the hsp70 homolog) to polypeptides by promoting its phosphorylation. Proc Natl Acad Sci U S A. 1993 Sep 15; 90(18):8648-52. PMID: 8378342.
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  86. Sherman MYu, Goldberg AL. Heat shock in Escherichia coli alters the protein-binding properties of the chaperonin groEL by inducing its phosphorylation. Nature. 1992 May 14; 357(6374):167-9. PMID: 1349729.
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  87. Sherman MYu, Goldberg AL. Involvement of the chaperonin dnaK in the rapid degradation of a mutant protein in Escherichia coli. EMBO J. 1992 Jan; 11(1):71-7. PMID: 1740117.
    View in: PubMed
  88. Sherman MY, Goldberg AL. Formation in vitro of complexes between an abnormal fusion protein and the heat shock proteins from Escherichia coli and yeast mitochondria. J Bacteriol. 1991 Nov; 173(22):7249-56. PMID: 1938919.
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  89. Sherman MY. Interrelation between taxis and sporulation systems. FEBS Lett. 1982 Nov 8; 148(2):192-7. PMID: 6818048.
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  90. Vorobyeva NV, Sherman MYu, Glagolev AN. Bacterial chemotaxis controls the catabolite repression of flagellar biogenesis. FEBS Lett. 1982 Jul 5; 143(2):233-6. PMID: 6749548.
    View in: PubMed
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