Michael Sherman, PhD
Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, Moscow State University
MS, Moscow State University



I. Research in my lab has focused on understanding the molecular mechanisms underlying the central role of the heat shock protein Hsp72 in cancer. In cancer cells Hsp72 is often expressed at very high levels, and its expression correlates with the aggressiveness of tumors. Recently we have found that Hsp72 regulates early stages of tumorigenesis. Indeed, Hsp72 can control signaling pathways initiated by major oncogenes, resulting in avoiding growth inhibition and facilitating cell proliferation and transformation.

Our research addresses several questions:

(1) How Hsp72 keeps the p53 pathway activated by PIK3CA oncogene under control?

(2) How Hsp72 prevents cell senescence activated by Her2 oncogene.

II. In a distinct project we study a process of aggregation of abnormal polypeptides. When chaperone and protein degradation machineries fail to handle abnormal proteins, they aggregate and cause cell toxicity, which may give rise to various neurological disorders. As the last line of defense, a special machinery has evolved that transports these toxic aggregates to a centrosome location via microtubules, which leads to relieve of toxicity. The resulting non-toxic single large aggregate is called aggresome. Previously we have established a yeast model to study aggregation and toxicity of the disease-causing polypeptides with expanded polyglutamine domain. Now, using both yeast and mammalian systems, we are dissecting the pathway of aggresome formation.

Our current research within this project uses genetics and biochemical approaches to addresses the following questions:

(1) What cellular components are involved in aggresome formation?

(2) What signaling pathways control aggresome formation?

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Complex Role of Hsf1 in Breast Cancer
03/01/2014 - 02/28/2018 (PI)
Beth Israel Deaconess Medical Center, In NIH NCI
5R01CA176326-03

Agreement with SpalRx
12/01/2016 - 12/31/2017 (PI)
SpalRx Ltd


The Role of p62 in Cancer
07/01/2015 - 12/31/2015 (PI)
SL Oncology


Heat shock proteins in signaling and cancer
09/29/2009 - 08/31/2015 (PI)
NIH/National Cancer Institute
5R01CA081244-15

Testing of sponsor's materials in cell cultures and animal models
02/15/2014 - 06/30/2015 (PI)
SL Oncology


Age Dependence of Breast Cancer
07/01/2013 - 06/30/2015 (PI)
NIH/National Cancer Institute
5R21CA178563-02

Anti-cancer Immunization
02/15/2013 - 12/31/2014 (PI)
SL Oncology


THE MIT CENTER FOR SINGLE-CCELL DYNAMICS IN CANCER (SCDC)
08/01/2010 - 07/31/2014 (PI)
Massachusetts Institute of Technology NIH NCI
5U54CA143874-05

Cell Mechanisms of Abnormal Protein Aggregation
07/01/2004 - 02/28/2013 (PI)
NIH/National Institute of General Medica
5R01GM086890-08

HEAT SHOCK PROTEINS IN CANCER AND SIGNALING
09/29/2009 - 08/31/2012 (PI)
NIH/National Cancer Institute
5R01CA081244-13

Showing 10 of 13 results. Show All Results



Yr Title Project-Sub Proj Pubs
2017 Complex Role of HSF1 in Breast Cancer 5R01CA176326-04 7
2015 Complex Role of HSF1 in Breast Cancer 5R01CA176326-02 7
2014 Complex Role of HSF1 in Breast Cancer 1R01CA176326-01A1 7
2014 Age Dependence of Breast Cancer 5R21CA178563-02 1
2013 Age Dependence of Breast Cancer 1R21CA178563-01 1
2013 Heat shock proteins in signaling and cancer 5R01CA081244-15 11
2012 Cellular Mechanisms of Aggregation of Abnormal Proteins 5R01GM086890-08 6
2012 Heat shock proteins in signaling and cancer 5R01CA081244-14 11
2011 CHARACTERIZATION OF HUNTINGTON AND PARKINSON AGGREGATES BY MASS SPECTROMETRY 5P41RR010888-15-5120 236
2011 Cellular Mechanisms of Aggregation of Abnormal Proteins 5R01GM086890-07 6
Showing 10 of 40 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY. Correction for Gabai et al., "Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR". Mol Cell Biol. 2017 Oct 15; 37(20).View Related Profiles. PMID: 28951485.
  2. Halenova T, Savchuk O, Ostapchenko L, Chursov A, Fridlyand N, Komissarov AB, Venanzi F, Kolesnikov SI, Sufianov AA, Sherman MY, Gabai VL, Shneider AM. P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions. Oncotarget. 2017 Aug 22; 8(34):56030-56040.View Related Profiles. PMID: 28915571.
  3. McFarland CD, Yaglom JA, Wojtkowiak JW, Scott JG, Morse DL, Sherman MY, Mirny LA. The Damaging Effect of Passenger Mutations on Cancer Progression. Cancer Res. 2017 Sep 15; 77(18):4763-4772.View Related Profiles. PMID: 28536279.
  4. Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 Jan 15; 26(2):305-319. PMID: 28065882; DOI: 10.1093/hmg/ddw387;.
  5. Gabai VL, Yaglom JA, Wang Y, Meng L, Shao H, Kim G, Colvin T, Gestwicki J, Sherman MY. Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells. Cancer Res. 2016 Oct 15; 76(20):5926-5932.View Related Profiles. PMID: 27503927.
  6. Lee do H, Sherman MY, Goldberg AL. The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins. Biochem Biophys Res Commun. 2016 Jun 17; 475(1):100-6. PMID: 27178214; DOI: 10.1016/j.bbrc.2016.05.046;.
  7. Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY. RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. EMBO J. 2015 Sep 14; 34(18):2363-82.View Related Profiles. PMID: 26303906; PMCID: PMC4570522; DOI: 10.15252/embj.201591245;.
  8. Sabbieti MG, Agas D, Capitani M, Marchetti L, Concetti A, Vullo C, Catone G, Gabai V, Shifrin V, Sherman MY, Shneider A, Venanzi FM. Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent. Oncotarget. 2015 Feb 28; 6(6):3590-9.View Related Profiles. PMID: 25668818; PMCID: PMC4414139.
  9. Gong J, Weng D, Eguchi T, Murshid A, Sherman MY, Song B, Calderwood SK. Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis. Oncogene. 2015 Oct; 34(43):5460-71.View Related Profiles. PMID: 25659585; DOI: 10.1038/onc.2015.1;.
  10. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8.View Related Profiles. PMID: 25564440; PMCID: PMC4456214; DOI: 10.1158/1535-7163.MCT-14-0650;.
Showing 10 of 89 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 89 publications over 26 distinct years, with a maximum of 7 publications in 2007 and 2012

YearPublications
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19994
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20162
20174
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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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