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PhD, Moscow State University
MS, Moscow State University

Websites

Research
Publications

BU Research
NIH RePORTER Research

Complex Role of Hsf1 in Breast Cancer
03/01/2014 - 02/28/2018 (Subcontract PI)
Beth Israel Deaconess Medical Center, Inc. NIH NCI
5R01CA176326-05

Agreement with SpalRx
12/01/2016 - 12/31/2017 (PI)
SpalRx Ltd

The Role of p62 in Cancer
07/01/2015 - 12/31/2015 (PI)
SL Oncology

Heat shock proteins in signaling and cancer
09/29/2009 - 08/31/2015 (PI)
NIH/National Cancer Institute
5R01CA081244-15

Testing of sponsor's materials in cell cultures and animal models
02/15/2014 - 06/30/2015 (PI)
SL Oncology

Age Dependence of Breast Cancer
07/01/2013 - 06/30/2015 (PI)
NIH/National Cancer Institute
5R21CA178563-02

Anti-cancer Immunization
02/15/2013 - 12/31/2014 (PI)
SL Oncology

HEAT SHOCK PROTEINS IN CANCER AND SIGNALING
09/29/2009 - 08/31/2014 (PI)
NIH/National Cancer Institute
5R01CA081244-13

THE MIT CENTER FOR SINGLE-CCELL DYNAMICS IN CANCER (SCDC)
08/01/2010 - 07/31/2014 (Subcontract PI)
Massachusetts Institute of Technology NIH NCI
5U54CA143874-05

Cell Mechanisms of Abnormal Protein Aggregation
07/01/2004 - 02/28/2013 (PI)
NIH/National Institute of General Medical Sciences
5R01GM086890-08

Showing 10 of 13 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2018	Complex Role of HSF1 in Breast Cancer	5R01CA176326-05	15
2017	Complex Role of HSF1 in Breast Cancer	5R01CA176326-04	15
2016	Complex Role of HSF1 in Breast Cancer	5R01CA176326-03	15
2015	Complex Role of HSF1 in Breast Cancer	5R01CA176326-02	15
2014	Complex Role of HSF1 in Breast Cancer	1R01CA176326-01A1	15
2014	Age Dependence of Breast Cancer	5R21CA178563-02	1
2013	Age Dependence of Breast Cancer	1R21CA178563-01	1
2013	Heat shock proteins in signaling and cancer	5R01CA081244-15	14
2012	Cellular Mechanisms of Aggregation of Abnormal Proteins	5R01GM086890-08	8
2012	Heat shock proteins in signaling and cancer	5R01CA081244-14	14

Showing 10 of 42 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Yaglom JA, Wang Y, Li A, Li Z, Monti S, Alexandrov I, Lu X, Sherman MY. Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations. Sci Rep. 2018 02 14; 8(1):3010.View Related Profiles.

Yaglom, Julia
Sherman, Michael

PMID: 29445088

Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY. Correction for Gabai et al., "Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR". Mol Cell Biol. 2017 10 15; 37(20).View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 28951485

Halenova T, Savchuk O, Ostapchenko L, Chursov A, Fridlyand N, Komissarov AB, Venanzi F, Kolesnikov SI, Sufianov AA, Sherman MY, Gabai VL, Shneider AM. P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions. Oncotarget. 2017 Aug 22; 8(34):56030-56040.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 28915571

McFarland CD, Yaglom JA, Wojtkowiak JW, Scott JG, Morse DL, Sherman MY, Mirny LA. The Damaging Effect of Passenger Mutations on Cancer Progression. Cancer Res. 2017 Sep 15; 77(18):4763-4772.View Related Profiles.

Yaglom, Julia
Sherman, Michael

PMID: 28536279

Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 Jan 15; 26(2):305-319. PMID: 28065882; DOI: 10.1093/hmg/ddw387;

Gabai VL, Yaglom JA, Wang Y, Meng L, Shao H, Kim G, Colvin T, Gestwicki J, Sherman MY. Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells. Cancer Res. 2016 Oct 15; 76(20):5926-5932.View Related Profiles.

Yaglom, Julia
Meng, Le
Sherman, Michael
Colvin, Teresa
Gabai, Vladimir

PMID: 27503927; PMCID: PMC5065765; DOI: 10.1158/0008-5472.CAN-16-0800;

Lee do H, Sherman MY, Goldberg AL. The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins. Biochem Biophys Res Commun. 2016 Jun 17; 475(1):100-6. PMID: 27178214; DOI: 10.1016/j.bbrc.2016.05.046;

Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY. RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. EMBO J. 2015 Sep 14; 34(18):2363-82.View Related Profiles.

Meriin, Anatoli
Costello, Catherine
McComb, Mark
Sherman, Michael
Zaarur, Nava

PMID: 26303906; PMCID: PMC4570522; DOI: 10.15252/embj.201591245;

Sabbieti MG, Agas D, Capitani M, Marchetti L, Concetti A, Vullo C, Catone G, Gabai V, Shifrin V, Sherman MY, Shneider A, Venanzi FM. Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent. Oncotarget. 2015 Feb 28; 6(6):3590-9.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 25668818; PMCID: PMC4414139

Gong J, Weng D, Eguchi T, Murshid A, Sherman MY, Song B, Calderwood SK. Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis. Oncogene. 2015 Oct; 34(43):5460-71.View Related Profiles.

Weng, Desheng
Gong, Jianlin
Sherman, Michael

PMID: 25659585; PMCID: PMC7331470; DOI: 10.1038/onc.2015.1;

Showing 10 of 93 results. Show More

Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8.View Related Profiles.

Sherman, Michael
Colvin, Teresa

PMID: 25564440; PMCID: PMC4456214; DOI: 10.1158/1535-7163.MCT-14-0650;

Gabai V, Venanzi FM, Bagashova E, Rud O, Mariotti F, Vullo C, Catone G, Sherman MY, Concetti A, Chursov A, Latanova A, Shcherbinina V, Shifrin V, Shneider A. Pilot study of p62 DNA vaccine in dogs with mammary tumors. Oncotarget. 2014 Dec 30; 5(24):12803-10.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 25296974; PMCID: PMC4350343

Sherman MY, Gabai VL. Hsp70 in cancer: back to the future. Oncogene. 2015 Aug 6; 34(32):4153-61.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 25347739; PMCID: PMC4411196; DOI: 10.1038/onc.2014.349;

Yaglom JA, McFarland C, Mirny L, Sherman MY. Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer. Oncotarget. 2014 Sep 30; 5(18):8367-78.View Related Profiles.

Yaglom, Julia
Sherman, Michael

PMID: 25252808; PMCID: PMC4226689

Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, Takayama S, Sherman MY. Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Res. 2014 Sep 1; 74(17):4731-40.View Related Profiles.

Gong, Jianlin
Sherman, Michael
Garcia-Marcos, Mikel
Gummuluru, Suryaram
Colvin, Teresa
Gabai, Vladimir

PMID: 24994713; PMCID: PMC4174322; DOI: 10.1158/0008-5472.CAN-14-0747;

Colvin TA, Gabai VL, Sherman MY. Proteotoxicity is not the reason for the dependence of cancer cells on the major chaperone Hsp70. Cell Cycle. 2014; 13(14):2306-10.View Related Profiles.

Sherman, Michael
Colvin, Teresa
Gabai, Vladimir

PMID: 24911412; PMCID: PMC4111684; DOI: 10.4161/cc.29296;

Zaarur N, Meriin AB, Bejarano E, Xu X, Gabai VL, Cuervo AM, Sherman MY. Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport. Mol Cell Biol. 2014 Apr; 34(7):1336-48.View Related Profiles.

Meriin, Anatoli
Sherman, Michael
Zaarur, Nava
Gabai, Vladimir

PMID: 24469403; PMCID: PMC3993571; DOI: 10.1128/MCB.00103-14;

Sherman MY, Qian SB. Less is more: improving proteostasis by translation slow down. Trends Biochem Sci. 2013 Dec; 38(12):585-91. PMID: 24126073; DOI: 10.1016/j.tibs.2013.09.003;

Venanzi F, Shifrin V, Sherman M, Gabai V, Kiselev O, Komissarov A, Grudinin M, Shartukova M, Romanovskaya-Romanko EA, Kudryavets Y, Bezdenezhnykh N, Lykhova O, Semesyuk N, Concetti A, Tsyb A, Filimonova M, Makarchuk V, Yakubovsky R, Chursov A, Shcherbinina V, Shneider A. Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector. Oncotarget. 2013 Oct; 4(10):1829-35.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 24121124; PMCID: PMC3858567

Bergholz J, Zhang Y, Wu J, Meng L, Walsh EM, Rai A, Sherman MY, Xiao ZX. ?Np63a regulates Erk signaling via MKP3 to inhibit cancer metastasis. Oncogene. 2014 Jan 9; 33(2):212-24.View Related Profiles.

Meng, Le
Sherman, Michael
Xiao, Zhi-Xiong

PMID: 23246965; PMCID: PMC3962654; DOI: 10.1038/onc.2012.564;

Meriin AB, Mense M, Colbert JD, Liang F, Bihler H, Zaarur N, Rock KL, Sherman MY. A novel approach to recovery of function of mutant proteins by slowing down translation. J Biol Chem. 2012 Oct 5; 287(41):34264-72.View Related Profiles.

Meriin, Anatoli
Sherman, Michael
Zaarur, Nava

PMID: 22902621; PMCID: PMC3464534; DOI: 10.1074/jbc.M112.397307;

Kim G, Meriin AB, Gabai VL, Christians E, Benjamin I, Wilson A, Wolozin B, Sherman MY. The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell. 2012 Aug; 11(4):617-27.View Related Profiles.

Meriin, Anatoli
Wilson, Andrew
Wolozin, Benjamin
Kim-Sun, Geunwon
Sherman, Michael
Gabai, Vladimir

PMID: 22510478; PMCID: PMC3433748; DOI: 10.1111/j.1474-9726.2012.00827.x;

Gong H, Romanova NV, Allen KD, Chandramowlishwaran P, Gokhale K, Newnam GP, Mieczkowski P, Sherman MY, Chernoff YO. Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast. PLoS Genet. 2012; 8(4):e1002634. PMID: 22536159; PMCID: PMC3334884; DOI: 10.1371/journal.pgen.1002634;

Meriin AB, Zaarur N, Sherman MY. Association of translation factor eEF1A with defective ribosomal products generates a signal for aggresome formation. J Cell Sci. 2012 Jun 1; 125(Pt 11):2665-74.View Related Profiles.

Meriin, Anatoli
Sherman, Michael
Zaarur, Nava

PMID: 22357952; PMCID: PMC3403235; DOI: 10.1242/jcs.098954;

Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY. Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol Cell Biol. 2012 Mar; 32(5):929-40.View Related Profiles.

Kim-Sun, Geunwon
Sherman, Michael
Colvin, Teresa
Gabai, Vladimir

PMID: 22215620; PMCID: PMC3295200; DOI: 10.1128/MCB.05921-11;

Wong E, Bejarano E, Rakshit M, Lee K, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM. Molecular determinants of selective clearance of protein inclusions by autophagy. Nat Commun. 2012; 3:1240.View Related Profiles.

Sherman, Michael
Zaarur, Nava

PMID: 23212369; PMCID: PMC3526956; DOI: 10.1038/ncomms2244;

Sherman MY, Meng L, Stampfer M, Gabai VL, Yaglom JA. Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells. Aging Cell. 2011 Dec; 10(6):949-61.View Related Profiles.

Yaglom, Julia
Meng, Le
Sherman, Michael
Gabai, Vladimir

PMID: 21824272; PMCID: PMC3433764; DOI: 10.1111/j.1474-9726.2011.00736.x;

Sherman MY. Proteotoxic stress targeted therapy (PSTT). Oncotarget. 2011 May; 2(5):356-7. PMID: 21636878; PMCID: PMC3248185

Meng L, Hunt C, Yaglom JA, Gabai VL, Sherman MY. Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis. Oncogene. 2011 Jun 23; 30(25):2836-45.View Related Profiles.

Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 21297664; PMCID: PMC3433756; DOI: 10.1038/onc.2011.5;

Wang Z, Gall JM, Bonegio RG, Havasi A, Hunt CR, Sherman MY, Schwartz JH, Borkan SC. Induction of heat shock protein 70 inhibits ischemic renal injury. Kidney Int. 2011 Apr; 79(8):861-70.View Related Profiles.

Havasi, Andrea
Schwartz, John
Gall, Jonathan
Sherman, Michael
Bonegio, Ramon
Borkan, Steven
Wang, Zhiyong

PMID: 21270764; PMCID: PMC8006160; DOI: 10.1038/ki.2010.527;

Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderweyde T, Vanderwyde T, Citro A, Mehta T, Zaarur N, McKee A, Bowser R, Sherman M, Petrucelli L, Wolozin B. Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. PLoS One. 2010; 5(10):e13250.View Related Profiles.

McKee, Ann
Wolozin, Benjamin
Sherman, Michael
Zaarur, Nava
Vanderweyde, Tara

PMID: 20948999; PMCID: PMC2952586; DOI: 10.1371/journal.pone.0013250;

Meriin AB, Wang Y, Sherman MY. Isolation of aggresomes and other large aggregates. Curr Protoc Cell Biol. 2010 Sep; Chapter 3:Unit 3.38.1-9.View Related Profiles.

Meriin, Anatoli
Sherman, Michael

PMID: 20853343; PMCID: PMC3422749; DOI: 10.1002/0471143030.cb0338s48;

Meng L, Gabai VL, Sherman MY. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. Oncogene. 2010 Sep 16; 29(37):5204-13.View Related Profiles.

Meng, Le
Sherman, Michael
Gabai, Vladimir

PMID: 20622894; PMCID: PMC2940982; DOI: 10.1038/onc.2010.277;

Sherman M. Major heat shock protein Hsp72 controls oncogene-induced senescence. Ann N Y Acad Sci. 2010 Jun; 1197:152-7. PMID: 20536844; DOI: 10.1111/j.1749-6632.2010.05196.x;

Gabai VL, Sherman MY, Yaglom JA. HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling. Oncogene. 2010 Apr 1; 29(13):1952-62.View Related Profiles.

Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 20062073; DOI: 10.1038/onc.2009.480;

Gabai VL, Yaglom JA, Waldman T, Sherman MY. Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. Mol Cell Biol. 2009 Jan; 29(2):559-69.View Related Profiles.

Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 19001088; PMCID: PMC2612502; DOI: 10.1128/MCB.01041-08;

Wang Y, Meriin AB, Zaarur N, Romanova NV, Chernoff YO, Costello CE, Sherman MY. Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery. FASEB J. 2009 Feb; 23(2):451-63.View Related Profiles.

Meriin, Anatoli
Costello, Catherine
Sherman, Michael
Zaarur, Nava

PMID: 18854435; PMCID: PMC2630789; DOI: 10.1096/fj.08-117614;

Zaarur N, Meriin AB, Gabai VL, Sherman MY. Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin 1. J Biol Chem. 2008 Oct 10; 283(41):27575-84.View Related Profiles.

Meriin, Anatoli
Sherman, Michael
Zaarur, Nava
Gabai, Vladimir

PMID: 18635553; DOI: 10.1074/jbc.M802216200;

Dinov ID, Rubin D, Lorensen W, Dugan J, Ma J, Murphy S, Kirschner B, Bug W, Sherman M, Floratos A, Kennedy D, Jagadish HV, Schmidt J, Athey B, Califano A, Musen M, Altman R, Kikinis R, Kohane I, Delp S, Parker DS, Toga AW. iTools: a framework for classification, categorization and integration of computational biology resources. PLoS One. 2008; 3(5):e2265. PMID: 18509477; PMCID: PMC2386255; DOI: 10.1371/journal.pone.0002265;

Ilyinskii PO, Thoidis G, Sherman MY, Shneider A. Adjuvant potential of aggregate-forming polyglutamine domains. Vaccine. 2008 Jun 19; 26(26):3223-6. PMID: 18467011; DOI: 10.1016/j.vaccine.2008.03.078;

Gabai VL, O'Callaghan-Sunol C, Meng L, Sherman MY, Yaglom J. Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses. Cancer Res. 2008 Mar 15; 68(6):1834-42.View Related Profiles.

Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 18339864; DOI: 10.1158/0008-5472.CAN-07-5656;

Park MA, Yacoub A, Rahmani M, Zhang G, Hart L, Hagan MP, Calderwood SK, Sherman MY, Koumenis C, Spiegel S, Chen CS, Graf M, Curiel DT, Fisher PB, Grant S, Dent P. OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells. Mol Pharmacol. 2008 Apr; 73(4):1168-84. PMID: 18182481; PMCID: PMC2674576; DOI: 10.1124/mol.107.042697;

O'Callaghan-Sunol C, Gabai VL, Sherman MY. Hsp27 modulates p53 signaling and suppresses cellular senescence. Cancer Res. 2007 Dec 15; 67(24):11779-88.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 18089808

Sherman M, Multhoff G. Heat shock proteins in cancer. Ann N Y Acad Sci. 2007 Oct; 1113:192-201. PMID: 17978282

Sherman M. Universal genome in the origin of metazoa: thoughts about evolution. Cell Cycle. 2007 Aug 1; 6(15):1873-7. PMID: 17660714

Sherman MY, Sherman M, Gabai V, O'Callaghan C, Yaglom J. Molecular chaperones regulate p53 and suppress senescence programs. FEBS Lett. 2007 Jul 31; 581(19):3711-5.View Related Profiles.

Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 17555746; PMCID: PMC3433766

Wang Y, Meriin AB, Costello CE, Sherman MY. Characterization of proteins associated with polyglutamine aggregates: a novel approach towards isolation of aggregates from protein conformation disorders. Prion. 2007 Apr-Jun; 1(2):128-35.View Related Profiles.

Meriin, Anatoli
Costello, Catherine
Sherman, Michael

PMID: 19164926; PMCID: PMC2634453; DOI: 10.4161/pri.1.2.4440;

Meriin AB, Zhang X, Alexandrov IM, Salnikova AB, Ter-Avanesian MD, Chernoff YO, Sherman MY. Endocytosis machinery is involved in aggregation of proteins with expanded polyglutamine domains. FASEB J. 2007 Jun; 21(8):1915-25.View Related Profiles.

Meriin, Anatoli
Sherman, Michael

PMID: 17341688

Yaglom JA, Gabai VL, Sherman MY. High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways. Cancer Res. 2007 Mar 1; 67(5):2373-81.View Related Profiles.

Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 17332370

O'Callaghan-Sunol C, Sherman MY. Heat shock transcription factor (HSF1) plays a critical role in cell migration via maintaining MAP kinase signaling. Cell Cycle. 2006 Jul; 5(13):1431-7. PMID: 16855393

Sherman MY, Gabai VL. Multiple thermometers in mammalian cells: why do cells from homeothermic organisms need to measure temperature? Sci STKE. 2006 Mar 28; 2006(328):pe16.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 16569818

Zaarur N, Gabai VL, Porco JA, Calderwood S, Sherman MY. Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res. 2006 Feb 1; 66(3):1783-91.View Related Profiles.

Porco, John
Sherman, Michael
Zaarur, Nava
Gabai, Vladimir

PMID: 16452239

Ganusova EE, Ozolins LN, Bhagat S, Newnam GP, Wegrzyn RD, Sherman MY, Chernoff YO. Modulation of prion formation, aggregation, and toxicity by the actin cytoskeleton in yeast. Mol Cell Biol. 2006 Jan; 26(2):617-29. PMID: 16382152; PMCID: PMC1346895

Lei X, Zaarur N, Sherman MY, Porco JA. Stereocontrolled synthesis of a complex library via elaboration of angular epoxyquinol scaffolds. J Org Chem. 2005 Aug 5; 70(16):6474-83.View Related Profiles.

Porco, John
Sherman, Michael
Zaarur, Nava

PMID: 16050712

Meriin AB, Sherman MY. Role of molecular chaperones in neurodegenerative disorders. Int J Hyperthermia. 2005 Aug; 21(5):403-19.View Related Profiles.

Meriin, Anatoli
Sherman, Michael

PMID: 16048838

Gabai VL, Budagova KR, Sherman MY. Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents. Oncogene. 2005 May 5; 24(20):3328-38.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 15735699

Gokhale KC, Newnam GP, Sherman MY, Chernoff YO. Modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model. J Biol Chem. 2005 Jun 17; 280(24):22809-18. PMID: 15824100

Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG. A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):892-7.View Related Profiles.

Meriin, Anatoli
Sherman, Michael

PMID: 15642944; PMCID: PMC545525; DOI: 10.1073/pnas.0408936102;

Sherman MY. Yeast prions: protein aggregation is not enough. PLoS Biol. 2004 Apr; 2(4):E125. PMID: 15094820; PMCID: PMC387287

Meriin AB, Zhang X, Miliaras NB, Kazantsev A, Chernoff YO, McCaffery JM, Wendland B, Sherman MY. Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis. Mol Cell Biol. 2003 Nov; 23(21):7554-65.View Related Profiles.

Meriin, Anatoli
Sherman, Michael

PMID: 14560003; PMCID: PMC207640

Yaglom JA, Ekhterae D, Gabai VL, Sherman MY. Regulation of necrosis of H9c2 myogenic cells upon transient energy deprivation. Rapid deenergization of mitochondria precedes necrosis and is controlled by reactive oxygen species, stress kinase JNK, HSP72 and ARC. J Biol Chem. 2003 Dec 12; 278(50):50483-96.View Related Profiles.

Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 14523009

Yaglom J, O'Callaghan-Sunol C, Gabai V, Sherman MY. Inactivation of dual-specificity phosphatases is involved in the regulation of extracellular signal-regulated kinases by heat shock and hsp72. Mol Cell Biol. 2003 Jun; 23(11):3813-24.View Related Profiles.

Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 12748284; PMCID: PMC155207

Sherman MY, Muchowski PJ. Making yeast tremble: yeast models as tools to study neurodegenerative disorders. Neuromolecular Med. 2003; 4(1-2):133-46. PMID: 14528057

Mattson MP, Sherman M. Perturbed signal transduction in neurodegenerative disorders involving aberrant protein aggregation. Neuromolecular Med. 2003; 4(1-2):109-32. PMID: 14528056

Meriin AB, Zhang X, He X, Newnam GP, Chernoff YO, Sherman MY. Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1. J Cell Biol. 2002 Jun 10; 157(6):997-1004.View Related Profiles.

Meriin, Anatoli
Sherman, Michael

PMID: 12058016; PMCID: PMC2174031

Lechpammer S, Asea A, Mallick R, Zhong R, Sherman MY, Calderwood SK. Development of an XTT tetrazolium salt-based assay for detection of specific hyperthermia sensitizers in a high-flux screening programme. Int J Hyperthermia. 2002 May-Jun; 18(3):203-15. PMID: 12061330

Gabai VL, Mabuchi K, Mosser DD, Sherman MY. Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Mol Cell Biol. 2002 May; 22(10):3415-24.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 11971973; PMCID: PMC133785

Gabai VL, Sherman MY. Invited review: Interplay between molecular chaperones and signaling pathways in survival of heat shock. J Appl Physiol (1985). 2002 Apr; 92(4):1743-8.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 11896044

Meriin AB, Mabuchi K, Gabai VL, Yaglom JA, Kazantsev A, Sherman MY. Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1. J Cell Biol. 2001 May 14; 153(4):851-64.View Related Profiles.

Meriin, Anatoli
Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 11352944; PMCID: PMC2192371

Sherman MY, Goldberg AL. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron. 2001 Jan; 29(1):15-32. PMID: 11182078

Gabai VL, Meriin AB, Yaglom JA, Wei JY, Mosser DD, Sherman MY. Suppression of stress kinase JNK is involved in HSP72-mediated protection of myogenic cells from transient energy deprivation. HSP72 alleviates the stewss-induced inhibition of JNK dephosphorylation. J Biol Chem. 2000 Dec 1; 275(48):38088-94.View Related Profiles.

Meriin, Anatoli
Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 10978340

Huang HC, Sherman MY, Kandror O, Goldberg AL. The molecular chaperone DnaJ is required for the degradation of a soluble abnormal protein in Escherichia coli. J Biol Chem. 2001 Feb 9; 276(6):3920-8. PMID: 11062236; DOI: 10.1074/jbc.M002937200;

Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol. 2000 Oct; 20(19):7146-59.View Related Profiles.

Meriin, Anatoli
Sherman, Michael

PMID: 10982831; PMCID: PMC86268

Gabai VL, Yaglom JA, Volloch V, Meriin AB, Force T, Koutroumanis M, Massie B, Mosser DD, Sherman MY. Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol Cell Biol. 2000 Sep; 20(18):6826-36.View Related Profiles.

Meriin, Anatoli
Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 10958679; PMCID: PMC86215

Volloch V, Gabai VL, Rits S, Force T, Sherman MY. HSP72 can protect cells from heat-induced apoptosis by accelerating the inactivation of stress kinase JNK. Cell Stress Chaperones. 2000 Apr; 5(2):139-47.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 11147965; PMCID: PMC312900

Volloch V, Gabai VL, Rits S, Sherman MY. ATPase activity of the heat shock protein hsp72 is dispensable for its effects on dephosphorylation of stress kinase JNK and on heat-induced apoptosis. FEBS Lett. 1999 Nov 12; 461(1-2):73-6.View Related Profiles.

Sherman, Michael
Gabai, Vladimir

PMID: 10561499

Yaglom JA, Gabai VL, Meriin AB, Mosser DD, Sherman MY. The function of HSP72 in suppression of c-Jun N-terminal kinase activation can be dissociated from its role in prevention of protein damage. J Biol Chem. 1999 Jul 16; 274(29):20223-8.View Related Profiles.

Meriin, Anatoli
Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 10400639

Volloch VZ, Sherman MY. Oncogenic potential of Hsp72. Oncogene. 1999 Jun 17; 18(24):3648-51. PMID: 10380887; DOI: 10.1038/sj.onc.1202525;

Meriin AB, Yaglom JA, Gabai VL, Zon L, Ganiatsas S, Mosser DD, Zon L, Sherman MY. Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol Cell Biol. 1999 Apr; 19(4):2547-55.View Related Profiles.

Meriin, Anatoli
Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 10082520; PMCID: PMC84047

Volloch V, Mosser DD, Massie B, Sherman MY. Reduced thermotolerance in aged cells results from a loss of an hsp72-mediated control of JNK signaling pathway. Cell Stress Chaperones. 1998 Dec; 3(4):265-71. PMID: 9880239; PMCID: PMC312972

Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett. 1998 Oct 30; 438(1-2):1-4.View Related Profiles.

Meriin, Anatoli
Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 9821948

Meriin AB, Gabai VL, Yaglom J, Shifrin VI, Sherman MY. Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis. J Biol Chem. 1998 Mar 13; 273(11):6373-9.View Related Profiles.

Meriin, Anatoli
Yaglom, Julia
Sherman, Michael
Gabai, Vladimir

PMID: 9497367

Gabai VL, Meriin AB, Mosser DD, Caron AW, Rits S, Shifrin VI, Sherman MY. Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance. J Biol Chem. 1997 Jul 18; 272(29):18033-7.View Related Profiles.

Meriin, Anatoli
Sherman, Michael
Gabai, Vladimir

PMID: 9218432

Lee DH, Sherman MY, Goldberg AL. Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Sep; 16(9):4773-81. PMID: 8756635; PMCID: PMC231478

Yaglom JA, Goldberg AL, Finley D, Sherman MY. The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation. Mol Cell Biol. 1996 Jul; 16(7):3679-84.View Related Profiles.

Yaglom, Julia
Sherman, Michael

PMID: 8668184; PMCID: PMC231363

Sherman MY, Goldberg AL. Involvement of molecular chaperones in intracellular protein breakdown. EXS. 1996; 77:57-78. PMID: 8856969

Nigam SK, Goldberg AL, Ho S, Rohde MF, Bush KT, Sherman MYu. A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily. J Biol Chem. 1994 Jan 21; 269(3):1744-9. PMID: 8294423

Sherman MY, Goldberg AL. Heat shock of Escherichia coli increases binding of dnaK (the hsp70 homolog) to polypeptides by promoting its phosphorylation. Proc Natl Acad Sci U S A. 1993 Sep 15; 90(18):8648-52. PMID: 8378342; PMCID: PMC47415

Sherman MYu, Goldberg AL. Heat shock in Escherichia coli alters the protein-binding properties of the chaperonin groEL by inducing its phosphorylation. Nature. 1992 May 14; 357(6374):167-9. PMID: 1349729; DOI: 10.1038/357167a0;

Sherman MYu, Goldberg AL. Involvement of the chaperonin dnaK in the rapid degradation of a mutant protein in Escherichia coli. EMBO J. 1992 Jan; 11(1):71-7. PMID: 1740117; PMCID: PMC556427

Sherman MY, Goldberg AL. Formation in vitro of complexes between an abnormal fusion protein and the heat shock proteins from Escherichia coli and yeast mitochondria. J Bacteriol. 1991 Nov; 173(22):7249-56. PMID: 1938919; PMCID: PMC209232

Sherman MY. Interrelation between taxis and sporulation systems. FEBS Lett. 1982 Nov 8; 148(2):192-7. PMID: 6818048

Vorobyeva NV, Sherman MYu, Glagolev AN. Bacterial chemotaxis controls the catabolite repression of flagellar biogenesis. FEBS Lett. 1982 Jul 5; 143(2):233-6. PMID: 6749548

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