Keywords
Last Name

Zhi-Xiong Xiao, PhD

TitleAdjunct Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-6011
ORCID ORCID Icon0000-0002-0183-0538
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
2011 REGULATION AND FUNCTION OF P63 5P41RR010888-15-5141 236
2010 REGULATION AND FUNCTION OF P63 5P41RR010888-14-6846 236
2010 Role of MDM2 in Cell Proliferation and Tumorigenesis 5R01CA079804-09 13
2009 REGULATION AND FUNCTION OF P63 5P41RR010888-13-6203 236
2009 Role of MDM2 in Cell Proliferation and Tumorigenesis 5R01CA079804-08 13
2008 REGULATION AND FUNCTION OF P63 5P41RR010888-12-5305 236
2008 Role of MDM2 in Cell Proliferation and Tumorigenesis 5R01CA079804-07 13
2007 REGULATION AND FUNCTION OF P63 2P41RR010888-11-8126 236
2007 Role of MDM2 in Cell Proliferation and Tumorigenesis 2R01CA079804-06A2 13
2006 Regulation of p53 in reespnse to genotoxic stress 5R01GM070017-04 6
Showing the 10 most recent of 19 results. Show All Results

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Fei Q, Shang K, Zhang J, Chuai S, Kong D, Zhou T, Fu S, Liang Y, Li C, Chen Z, Zhao Y, Yu Z, Huang Z, Hu M, Ying H, Chen Z, Zhang Y, Xing F, Zhu J, Xu H, Zhao K, Lu C, Atadja P, Xiao ZX, Li E, Shou J. Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53. Nat Commun. 2015; 6:8651. PMID: 26471002.
    View in: PubMed
  2. Yuan L, Lv Y, Li H, Gao H, Song S, Zhang Y, Xing G, Kong X, Wang L, Li Y, Zhou T, Gao D, Xiao ZX, Yin Y, Wei W, He F, Zhang L. Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat Cell Biol. 2015 Sep; 17(9):1169-81. PMID: 26280536.
    View in: PubMed
  3. Walsh EM, Niu M, Bergholz J, Xiao ZX. Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation. Biochem Biophys Res Commun. 2015 May 29; 461(2):293-9. PMID: 25871794.
    View in: PubMed
  4. Zhang H, Hu L, Qiu W, Deng T, Zhang Y, Bergholz J, Xiao ZX. MDMX exerts its oncogenic activity via suppression of retinoblastoma protein. Oncogene. 2015 Oct 29; 34(44):5560-9. PMID: 25703327.
    View in: PubMed
  5. Tong Y, Ying H, Liu R, Li L, Bergholz J, Xiao ZX. Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage. Cell Death Dis. 2015; 6:e1640. PMID: 25675300.
    View in: PubMed
  6. Yuan L, Chen Z, Song S, Wang S, Tian C, Xing G, Chen X, Xiao ZX, He F, Zhang L. p53 degradation by a coronavirus papain-like protease suppresses type I interferon signaling. J Biol Chem. 2015 Jan 30; 290(5):3172-82. PMID: 25505178.
    View in: PubMed
  7. Xiang X, Deng L, Zhang J, Zhang X, Lei T, Luan G, Yang C, Xiao ZX, Li Q, Li Q. A distinct expression pattern of cyclin K in mammalian testes suggests a functional role in spermatogenesis. PLoS One. 2014; 9(7):e101539. PMID: 25004108.
    View in: PubMed
  8. Wu J, Liang S, Bergholz J, He H, Walsh EM, Zhang Y, Xiao ZX. ?Np63a activates CD82 metastasis suppressor to inhibit cancer cell invasion. Cell Death Dis. 2014; 5:e1280. PMID: 24901051.
    View in: PubMed
  9. Tran D, Bergholz J, Zhang H, He H, Wang Y, Zhang Y, Li Q, Kirkland JL, Xiao ZX. Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence. Aging Cell. 2014 Aug; 13(4):669-78. PMID: 25070626.
    View in: PubMed
  10. Dai Q, Luan G, Deng L, Lei T, Kang H, Song X, Zhang Y, Xiao ZX, Li Q. Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation. Cell Rep. 2014 May 8; 7(3):735-46. PMID: 24768001.
    View in: PubMed
  11. Li C, Xiao ZX. Regulation of p63 protein stability via ubiquitin-proteasome pathway. Biomed Res Int. 2014; 2014:175721. PMID: 24822180.
    View in: PubMed
  12. Li C, Chang DL, Yang Z, Qi J, Liu R, He H, Li D, Xiao ZX. Pin1 modulates p63a protein stability in regulation of cell survival, proliferation and tumor formation. Cell Death Dis. 2013; 4:e943. PMID: 24309930.
    View in: PubMed
  13. Chen Q, Li D, Ren J, Li C, Xiao ZX. MUC1 activates JNK1 and inhibits apoptosis under genotoxic stress. Biochem Biophys Res Commun. 2013 Oct 11; 440(1):179-83. PMID: 24055030.
    View in: PubMed
  14. Du W, Yi Y, Zhang H, Bergholz J, Wu J, Ying H, Zhang Y, Xiao ZX. Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy. PLoS One. 2013; 8(4):e63179. PMID: 23638184.
    View in: PubMed
  15. Bergholz J, Zhang Y, Wu J, Meng L, Walsh EM, Rai A, Sherman MY, Xiao ZX. ?Np63a regulates Erk signaling via MKP3 to inhibit cancer metastasis. Oncogene. 2014 Jan 9; 33(2):212-24. PMID: 23246965.
    View in: PubMed
  16. Bergholz J, Xiao ZX. Role of p63 in Development, Tumorigenesis and Cancer Progression. Cancer Microenviron. 2012 Dec; 5(3):311-22. PMID: 22847008.
    View in: PubMed
  17. Gao WL, Li D, Xiao ZX, Liao QP, Yang HX, Li YX, Ji L, Wang YL. Detection of global DNA methylation and paternally imprinted H19 gene methylation in preeclamptic placentas. Hypertens Res. 2011 May; 34(5):655-61. PMID: 21326306.
    View in: PubMed
  18. Xiao ZX, Yin XC, Tan YF, Peng YH. [Effects of diallyl disulfide on apoptosis of human leukemia K562 cells and expression of Fas, FasL and caspase-8]. Zhongguo Dang Dai Er Ke Za Zhi. 2011 Jan; 13(1):53-6. PMID: 21251389.
    View in: PubMed
  19. Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG, Harper JW, Wei W. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 2010 Aug 9; 18(2):147-59. PMID: 20708156.
    View in: PubMed
  20. Guo J, Zhu T, Chen L, Nishioka T, Tsuji T, Xiao ZX, Chen CY. Differential sensitization of different prostate cancer cells to apoptosis. Genes Cancer. 2010 Aug; 1(8):836-46. PMID: 21132068.
    View in: PubMed
  21. Wu J, Bergholz J, Lu J, Sonenshein GE, Xiao ZX. TAp63 is a transcriptional target of NF-kappaB. J Cell Biochem. 2010 Mar 1; 109(4):702-10. PMID: 20052674.
    View in: PubMed
  22. Mineva ND, Wang X, Yang S, Ying H, Xiao ZX, Holick MF, Sonenshein GE. Inhibition of RelB by 1,25-dihydroxyvitamin D3 promotes sensitivity of breast cancer cells to radiation. J Cell Physiol. 2009 Sep; 220(3):593-9. PMID: 19373868.
    View in: PubMed
  23. Du W, Wu J, Walsh EM, Zhang Y, Chen CY, Xiao ZX. Nutlin-3 affects expression and function of retinoblastoma protein: role of retinoblastoma protein in cellular response to nutlin-3. J Biol Chem. 2009 Sep 25; 284(39):26315-21. PMID: 19648117.
    View in: PubMed
  24. Qiu W, Wu J, Walsh EM, Zhang Y, Chen CY, Fujita J, Xiao ZX. Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells. Oncogene. 2008 Jul 3; 27(29):4034-43. PMID: 18332869.
    View in: PubMed
  25. Zhang Y, Tuzova M, Xiao ZX, Cruikshank WW, Center DM. Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP. J Immunol. 2008 Jan 1; 180(1):402-8. PMID: 18097041.
    View in: PubMed
  26. Guo J, Zhu T, Xiao ZX, Chen CY. Modulation of intracellular signaling pathways to induce apoptosis in prostate cancer cells. J Biol Chem. 2007 Aug 17; 282(33):24364-72. PMID: 17573344.
    View in: PubMed
  27. Chang DL, Qiu W, Ying H, Zhang Y, Chen CY, Xiao ZX. ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2. Oncogene. 2007 Jul 12; 26(32):4627-34. PMID: 17297463.
    View in: PubMed
  28. Guo J, Zhu T, Collins L, Xiao ZX, Kim SH, Chen CY. Modulation of lung cancer growth arrest and apoptosis by Phellinus Linteus. Mol Carcinog. 2007 Feb; 46(2):144-54. PMID: 17131292.
    View in: PubMed
  29. Ying H, Xiao ZX. Targeting retinoblastoma protein for degradation by proteasomes. Cell Cycle. 2006 Mar; 5(5):506-8. PMID: 16552188.
    View in: PubMed
  30. Sdek P, Ying H, Chang DL, Qiu W, Zheng H, Touitou R, Allday MJ, Xiao ZX. MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol Cell. 2005 Dec 9; 20(5):699-708. PMID: 16337594.
    View in: PubMed
  31. Murray SA, Yang S, Demicco E, Ying H, Sherr DH, Hafer LJ, Rogers AE, Sonenshein GE, Xiao ZX. Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. J Cell Biochem. 2005 Aug 1; 95(5):875-84. PMID: 15844214.
    View in: PubMed
  32. Ying H, Chang DL, Zheng H, McKeon F, Xiao ZX. DNA-binding and transactivation activities are essential for TAp63 protein degradation. Mol Cell Biol. 2005 Jul; 25(14):6154-64. PMID: 15988026.
    View in: PubMed
  33. Currier N, Solomon SE, Demicco EG, Chang DL, Farago M, Ying H, Dominguez I, Sonenshein GE, Cardiff RD, Xiao ZX, Sherr DH, Seldin DC. Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors. Toxicol Pathol. 2005; 33(6):726-37. PMID: 16263698.
    View in: PubMed
  34. Sdek P, Ying H, Zheng H, Margulis A, Tang X, Tian K, Xiao ZX. The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. J Biol Chem. 2004 Dec 17; 279(51):53317-22. PMID: 15485814.
    View in: PubMed
  35. Gu L, Ying H, Zheng H, Murray SA, Xiao ZX. The MDM2 RING finger is required for cell cycle-dependent regulation of its protein expression. FEBS Lett. 2003 Jun 5; 544(1-3):218-22. PMID: 12782320.
    View in: PubMed
  36. Zheng H, You H, Zhou XZ, Murray SA, Uchida T, Wulf G, Gu L, Tang X, Lu KP, Xiao ZX. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature. 2002 Oct 24; 419(6909):849-53. PMID: 12397361.
    View in: PubMed
  37. You H, Zheng H, Murray SA, Yu Q, Uchida T, Fan D, Xiao ZX. IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry. J Cell Biochem. 2002; 84(2):211-6. PMID: 11787050.
    View in: PubMed
  38. Gallo-Hendrikx E, Murray SA, Vonderhaar BK, Xiao ZX. Vanadate disrupts mammary gland development in whole organ culture. Dev Dyn. 2001 Nov; 222(3):354-67. PMID: 11747071.
    View in: PubMed
  39. Charles A, Tang X, Crouch E, Brody JS, Xiao ZX. Retinoblastoma protein complexes with C/EBP proteins and activates C/EBP-mediated transcription. J Cell Biochem. 2001 Aug 21-Sep 5; 83(3):414-25. PMID: 11596110.
    View in: PubMed
  40. Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol Cell. 1998 Oct; 2(4):405-15. PMID: 9809062.
    View in: PubMed
  41. Xiao ZX, Ginsberg D, Ewen M, Livingston DM. Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4633-7. PMID: 8643455.
    View in: PubMed
  42. Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR, Livingston DM. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature. 1995 Jun 22; 375(6533):694-8. PMID: 7791904.
    View in: PubMed
  43. Xiao ZX, Fitzgerald-Hayes M. Functional interaction between the CSE2 gene product and centromeres in Saccharomyces cerevisiae. J Mol Biol. 1995 Apr 28; 248(2):255-63. PMID: 7739039.
    View in: PubMed
  44. Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994 Nov 15; 8(22):2665-79. PMID: 7958924.
    View in: PubMed
  45. McGrew JT, Xiao ZX, Fitzgerald-Hayes M. Saccharomyces cerevisiae mutants defective in chromosome segregation. Yeast. 1989 Jul-Aug; 5(4):271-84. PMID: 2675488.
    View in: PubMed
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