Keywords
Last Name

Maria Isabel Dominguez, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionHematology & Medical Oncology
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 414-1829
ORCID ORCID Icon0000-0001-9617-4141
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

InstitutionBoston Medical Center

 Awards and Honors

Start-EndDescription
1987-1988Basque Government: Undergraduate Fellowship
1988-1989Iberduero S.A.: Postgraduate Fellowship
1990-1994Basque Government: Postgraduate Fellowship
1994-1996Spanish Government: Postdoctoral Fellowship
1996-1998Basque Government: Postdoctoral Fellowship
1998The Company of Biologists: Travel Fellowship to Attend the 7th International Xenopus Meeting
2002-2003Cancer Center, BU School of Medicine: American Cancer Society Institutional Research Grant
2003-2004Department of Medicine, Boston University School of Medicine: Pilot Project Grant
2007-2008Karin Grunebaum Cancer Research Foundation: Junior Faculty Cancer Research Award
2007-2008Department of Medicine, Boston University School of Medicine: Pilot Project Grant
2008Department of Medicine, Boston University School of Medicine: Faculty Development Grant
2013Department of Medicine, Boston University School of Medicine: Faculty Development Grant
 Research Expertise & Professional Interests
My research interest is to understand the cascade of intracellular events that leads to the activation of Wnt signaling and the biological role of the Wnt pathway during organ development and maintenance. We have two areas of interest:

Our first area of interest is to characterize the molecular mechanism leading to activation (stabilization and nuclear translocation) of ß-catenin, the key intracellular Wnt component that is activated in many human tumors. For this, we are using Xenopus embryos, mammalian cell lines, and mice ablated for CK2 catalytic subunits.

Our second area of interest is to characterize the cellular and molecular mechanisms regulated by Wnt/ß-catenin signaling during embryonic organ morphogenesis. For this we are using mice ablated for CK2 subunits and Xenopus embryos.

 Self-Described Keywords
  • Carcinogens
  • Cardiovascular Abnormalities
  • Cell Transformation, Neoplastic
  • Developmental Biology
  • Signal Transduction
  • Wnt Proteins
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Apfel J, Parikh JR, Reischmann P, Ewing RM, Müller O, Xia Y, Dominguez I. Systems Biology of Cancer Editor: Sam Thiagalingam. The Wnt signaling network in Cancer. Cambridge University Press. 2015.
  2. Ortega C, Prince-Wright L, Dominguez I. Proceedings of the CK2-VII meeting. Editors Khalil Ahmed, Olaf Issinger and Ryszard Szyska. Role of CK2 in organ formation. 2015.
  3. Ortega CE, Seidner Y, Dominguez I. Mining CK2 in cancer. PLoS One. 2014; 9(12):e115609. PMID: 25541719.
    View in: PubMed
  4. Siriwardana NS, Meyer R, Havasi A, Dominguez I, Panchenko MV. Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex. Cell Cycle. 2014; 13(12):1885-901. PMID: 24739512.
    View in: PubMed
  5. Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I, Ehler E. Two distinct phosphorylation events govern the function of muscle FHOD3. Cell Mol Life Sci. 2013 Mar; 70(5):893-908. PMID: 23052206.
    View in: PubMed
  6. Papanicolaou KN, Kikuchi R, Ngoh GA, Coughlan KA, Dominguez I, Stanley WC, Walsh K. Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circ Res. 2012 Sep 28; 111(8):1012-26. PMID: 22904094.
    View in: PubMed
  7. Imbrie GA, Wu H, Seldin DC, Dominguez I. Asymmetric Localization of CK2a During Xenopus Oogenesis. Hum Genet Embryol. 2012 May 5; Suppl 4(1):11328. PMID: 25346867.
    View in: PubMed
  8. Revuelta-Cervantes J, Macias Alvarez L, Dominguez I. The Wiley-IUBMB Series on Biochemistry and Molecular Biology: Protein Kinase CK2. Editor: Lorenzo Pinna. CK2 in embryonic development. Wiley-Blackwell Publishing. John Wiley & Sons, Inc. 2012.
  9. Dominguez I, Degano IR, Chea K, Cha J, Toselli P, Seldin DC. CK2a is essential for embryonic morphogenesis. Mol Cell Biochem. 2011 Oct; 356(1-2):209-16. PMID: 21761203.
    View in: PubMed
  10. Rigato PO, de Alencar BC, de Vasconcelos JR, Dominguez MR, Araújo AF, Machado AV, Gazzinelli RT, Bruna-Romero O, Rodrigues MM. Heterologous plasmid DNA prime-recombinant human adenovirus 5 boost vaccination generates a stable pool of protective long-lived CD8(+) T effector memory cells specific for a human parasite, Trypanosoma cruzi. Infect Immun. 2011 May; 79(5):2120-30. PMID: 21357719.
    View in: PubMed
  11. Currier N, Chea K, Hlavacova M, Sussman DJ, Seldin DC, Dominguez I. Dynamic expression of a LEF-EGFP Wnt reporter in mouse development and cancer. Genesis. 2010 Mar; 48(3):183-94. PMID: 20146356.
    View in: PubMed
  12. Wu H, Symes K, Seldin DC, Dominguez I. Threonine 393 of beta-catenin regulates interaction with Axin. J Cell Biochem. 2009 Sep 1; 108(1):52-63. PMID: 19565571.
    View in: PubMed
  13. Dominguez I, Sonenshein GE, Seldin DC. Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer. Cell Mol Life Sci. 2009 Jun; 66(11-12):1850-7. PMID: 19387549.
    View in: PubMed
  14. Bryja V, Schambony A, Cajánek L, Dominguez I, Arenas E, Schulte G. Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways. EMBO Rep. 2008 Dec; 9(12):1244-50. PMID: 18953287.
    View in: PubMed
  15. Chitalia VC, Foy RL, Bachschmid MM, Zeng L, Panchenko MV, Zhou MI, Bharti A, Seldin DC, Lecker SH, Dominguez I, Cohen HT. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nat Cell Biol. 2008 Oct; 10(10):1208-16. PMID: 18806787.
    View in: PubMed
  16. Seldin DC, Lou DY, Toselli P, Landesman-Bollag E, Dominguez I. Gene targeting of CK2 catalytic subunits. Mol Cell Biochem. 2008 Sep; 316(1-2):141-7. PMID: 18594950.
    View in: PubMed
  17. Lou DY, Dominguez I, Toselli P, Landesman-Bollag E, O'Brien C, Seldin DC. The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development. Mol Cell Biol. 2008 Jan; 28(1):131-9. PMID: 17954558.
    View in: PubMed
  18. Farago M, Dominguez I, Landesman-Bollag E, Xu X, Rosner A, Cardiff RD, Seldin DC. Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis. Cancer Res. 2005 Jul 1; 65(13):5792-801. PMID: 15994955.
    View in: PubMed
  19. Seldin DC, Landesman-Bollag E, Farago M, Currier N, Lou D, Dominguez I. CK2 as a positive regulator of Wnt signalling and tumourigenesis. Mol Cell Biochem. 2005 Jun; 274(1-2):63-7. PMID: 16342409.
    View in: PubMed
  20. Dominguez I, Mizuno J, Wu H, Imbrie GA, Symes K, Seldin DC. A role for CK2alpha/beta in Xenopus early embryonic development. Mol Cell Biochem. 2005 Jun; 274(1-2):125-31. PMID: 16342412.
    View in: PubMed
  21. Currier N, Solomon SE, Demicco EG, Chang DL, Farago M, Ying H, Dominguez I, Sonenshein GE, Cardiff RD, Xiao ZX, Sherr DH, Seldin DC. Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors. Toxicol Pathol. 2005; 33(6):726-37. PMID: 16263698.
    View in: PubMed
  22. Green JB, Dominguez I, Davidson LA. Self-organization of vertebrate mesoderm based on simple boundary conditions. Dev Dyn. 2004 Nov; 231(3):576-81. PMID: 15376320.
    View in: PubMed
  23. Dominguez I, Mizuno J, Wu H, Song DH, Symes K, Seldin DC. Protein kinase CK2 is required for dorsal axis formation in Xenopus embryos. Dev Biol. 2004 Oct 1; 274(1):110-24. PMID: 15355792.
    View in: PubMed
  24. Song DH, Dominguez I, Mizuno J, Kaut M, Mohr SC, Seldin DC. CK2 phosphorylation of the armadillo repeat region of beta-catenin potentiates Wnt signaling. J Biol Chem. 2003 Jun 27; 278(26):24018-25. PMID: 12700239.
    View in: PubMed
  25. Dominguez I, Green JB. Missing links in GSK3 regulation. Dev Biol. 2001 Jul 15; 235(2):303-13. PMID: 11437438.
    View in: PubMed
  26. Dominguez I, Green JB. Dorsal downregulation of GSK3beta by a non-Wnt-like mechanism is an early molecular consequence of cortical rotation in early Xenopus embryos. Development. 2000 Feb; 127(4):861-8. PMID: 10648244.
    View in: PubMed
  27. Martínez-Gimeno C, Díaz-Meco MT, Domínguez I, Moscat J. Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: epsilon PKC, a novel prognostic factor for relapse and survival. Head Neck. 1995 Nov-Dec; 17(6):516-25. PMID: 8847210.
    View in: PubMed
  28. Dominguez I, Itoh K, Sokol SY. Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8498-502. PMID: 7667318.
    View in: PubMed
  29. Lozano J, Berra E, Municio MM, Diaz-Meco MT, Dominguez I, Sanz L, Moscat J. Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. J Biol Chem. 1994 Jul 29; 269(30):19200-2. PMID: 8034680.
    View in: PubMed
  30. Diaz-Meco MT, Dominguez I, Sanz L, Dent P, Lozano J, Municio MM, Berra E, Hay RT, Sturgill TW, Moscat J. zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. EMBO J. 1994 Jun 15; 13(12):2842-8. PMID: 8026469.
    View in: PubMed
  31. Sanz L, Berra E, Municio MM, Dominguez I, Lozano J, Johansen T, Moscat J, Diaz-Meco MT. Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element. J Biol Chem. 1994 Apr 1; 269(13):10044-9. PMID: 8144503.
    View in: PubMed
  32. Arenzana-Seisdedos F, Fernandez B, Dominguez I, Jacqué JM, Thomas D, Diaz-Meco MT, Moscat J, Virelizier JL. Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. J Virol. 1993 Nov; 67(11):6596-604. PMID: 8411362.
    View in: PubMed
  33. Berra E, Diaz-Meco MT, Dominguez I, Municio MM, Sanz L, Lozano J, Chapkin RS, Moscat J. Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell. 1993 Aug 13; 74(3):555-63. PMID: 7688666.
    View in: PubMed
  34. Diaz-Meco MT, Berra E, Municio MM, Sanz L, Lozano J, Dominguez I, Diaz-Golpe V, Lain de Lera MT, Alcamí J, Payá CV, et al. A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation. Mol Cell Biol. 1993 Aug; 13(8):4770-5. PMID: 8336714.
    View in: PubMed
  35. Dominguez I, Sanz L, Arenzana-Seisdedos F, Diaz-Meco MT, Virelizier JL, Moscat J. Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes. Mol Cell Biol. 1993 Feb; 13(2):1290-5. PMID: 8423794.
    View in: PubMed
  36. Dominguez I, Diaz-Meco MT, Municio MM, Berra E, García de Herreros A, Cornet ME, Sanz L, Moscat J. Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes. Mol Cell Biol. 1992 Sep; 12(9):3776-83. PMID: 1508183.
    View in: PubMed
  37. Diaz-Meco MT, Dominguez I, Sanz L, Municio MM, Berra E, Cornet ME, Garcia de Herreros A, Johansen T, Moscat J. Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals. Mol Cell Biol. 1992 Jan; 12(1):302-8. PMID: 1309592.
    View in: PubMed
  38. Dominguez I, Marshall MS, Gibbs JB, García de Herreros A, Cornet ME, Graziani G, Diaz-Meco MT, Johansen T, McCormick F, Moscat J. Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. EMBO J. 1991 Nov; 10(11):3215-20. PMID: 1655413.
    View in: PubMed
  39. García de Herreros A, Dominguez I, Diaz-Meco MT, Graziani G, Cornett ME, Guddal PH, Johansen T, Moscat J. Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21. J Biol Chem. 1991 Apr 15; 266(11):6825-9. PMID: 2016297.
    View in: PubMed
  40. Wolfe J. Conjugation in Tetrahymena: the relationship between the division cycle and cell pairing. Dev Biol. 1973 Dec; 35(2):221-31. PMID: 4207361.
    View in: PubMed
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