Keywords
Last Name

Barbara M. Schreiber, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-5094
ORCID ORCID Icon0000-0001-8560-4249
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
Research focuses on studying the role of inflammation on aortic smooth muscle cell function. A major focus has been studying the impact of acute phase serum amyloid A on the development of atherosclerosis. Most recently, efforts have been directed at evaluating the role of periodontal disease on the vasculature with an eye toward poor birth outcomes.

Dr. Schreiber is also the director of the graduate of studies in the Biochemistry department and co-PI on the Boston University Broadening Experiences in Scientific Training (BU’s BEST) award.

 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
2016 BU's BEST 5DP7OD020322-03
2015 BU's BEST 5DP7OD020322-02
2014 BU's BEST 1DP7OD020322-01
2010 Smooth muscle cell lipid metabolism and serum amyloid A 5R01HL079201-05 2
2009 Smooth muscle cell lipid metabolism and serum amyloid A 5R01HL079201-04 2
2008 Smooth muscle cell lipid metabolism and serum amyloid A 5R01HL079201-03 2
2007 Smooth muscle cell lipid metabolism and serum amyloid A 5R01HL079201-02 2
2007 CORE-BIOMODEL 5P01HL013262-34-9002 162
2006 CORE-BIOMODEL 5P01HL013262-33-9002 162
2006 Smooth muscle cell lipid metabolism and serum amyloid A 1R01HL079201-01A2 2
Showing the 10 most recent of 20 results. Show All Results

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pessolano LG, Sullivan CP, Seidl SE, Rich CB, Liscum L, Stone PJ, Sipe JD, Schreiber BM. Trafficking of endogenous smooth muscle cell cholesterol: a role for serum amyloid A and interleukin-1ß. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2741-50. PMID: 22995521.
    View in: PubMed
  2. Sullivan CP, Seidl SE, Rich CB, Raymondjean M, Schreiber BM. Secretory phospholipase A2, group IIA is a novel serum amyloid A target gene: activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism. J Biol Chem. 2010 Jan 1; 285(1):565-75. PMID: 19850938.
    View in: PubMed
  3. St Hilaire C, Yang D, Schreiber BM, Ravid K. B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells. J Cell Biochem. 2008 Apr 15; 103(6):1962-74. PMID: 17979185.
    View in: PubMed
  4. Yang D, Koupenova M, McCrann DJ, Kopeikina KJ, Kagan HM, Schreiber BM, Ravid K. The A2b adenosine receptor protects against vascular injury. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):792-6. PMID: 18184815.
    View in: PubMed
  5. Hurtado PA, Vora S, Sume SS, Yang D, St Hilaire C, Guo Y, Palamakumbura AH, Schreiber BM, Ravid K, Trackman PC. Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation. Biochem Biophys Res Commun. 2008 Feb 1; 366(1):156-61. PMID: 18060869.
    View in: PubMed
  6. Xu Y, McDonald J, Perloff E, Butticè G, Schreiber BM, Smith BD. Collagen and major histocompatibility class II expression in mesenchymal cells from CIITA hypomorphic mice. Mol Immunol. 2007 Mar; 44(7):1709-21. PMID: 16982097.
    View in: PubMed
  7. Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest. 2006 Jul; 116(7):1913-23. PMID: 16823489.
    View in: PubMed
  8. Nagata Y, Jones MR, Nguyen HG, McCrann DJ, St Hilaire C, Schreiber BM, Hashimoto A, Inagaki M, Earnshaw WC, Todokoro K, Ravid K. Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle. Exp Cell Res. 2005 May 1; 305(2):277-91. PMID: 15817153.
    View in: PubMed
  9. Schadinger SE, Bucher NL, Schreiber BM, Farmer SR. PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. Am J Physiol Endocrinol Metab. 2005 Jun; 288(6):E1195-205. PMID: 15644454.
    View in: PubMed
  10. Black LD, Brewer KK, Morris SM, Schreiber BM, Toselli P, Nugent MA, Suki B, Stone PJ. Effects of elastase on the mechanical and failure properties of engineered elastin-rich matrices. J Appl Physiol (1985). 2005 Apr; 98(4):1434-41. PMID: 15640390.
    View in: PubMed
  11. Johnson RJ, Williams JM, Schreiber BM, Elfe CD, Lennon-Hopkins KL, Skrzypek MS, White RD. Analysis of gene ontology features in microarray data using the Proteome BioKnowledge Library. In Silico Biol. 2005; 5(4):389-99. PMID: 16268783.
    View in: PubMed
  12. Hofmann CS, Wang X, Sullivan CP, Toselli P, Stone PJ, McLean SE, Mecham RP, Schreiber BM, Sonenshein GE. B-Myb represses elastin gene expression in aortic smooth muscle cells. J Biol Chem. 2005 Mar 4; 280(9):7694-701. PMID: 15615710.
    View in: PubMed
  13. Jones MR, Zhao Z, Sullivan CP, Schreiber BM, Stone PJ, Toselli PA, Kagan HM, Cohen RA, Ravid K. A(3) adenosine receptor deficiency does not influence atherogenesis. J Cell Biochem. 2004 Aug 1; 92(5):1034-43. PMID: 15258925.
    View in: PubMed
  14. Hofmann CS, Sullivan CP, Jiang HY, Stone PJ, Toselli P, Reis ED, Chereshnev I, Schreiber BM, Sonenshein GE. B-Myb represses vascular smooth muscle cell collagen gene expression and inhibits neointima formation after arterial injury. Arterioscler Thromb Vasc Biol. 2004 Sep; 24(9):1608-13. PMID: 15256398.
    View in: PubMed
  15. Schreiber BM. Serum amyloid A; in search of function. Amyloid. 2002 Dec; 9(4):276-8. PMID: 12557759.
    View in: PubMed
  16. Yu J, Prado GN, Schreiber B, Polgar P, Polgar P, Taylor L. Role of prostaglandin E(2) EP receptors and cAMP in the expression of connective tissue growth factor. Arch Biochem Biophys. 2002 Aug 15; 404(2):302-8. PMID: 12147269.
    View in: PubMed
  17. Layne MD, Patel A, Chen YH, Rebel VI, Carvajal IM, Pellacani A, Ith B, Zhao D, Schreiber BM, Yet SF, Lee ME, Storch J, Perrella MA. Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 2001 Dec; 15(14):2733-5. PMID: 11606480.
    View in: PubMed
  18. Perrella MA, Pellacani A, Layne MD, Patel A, Zhao D, Schreiber BM, Storch J, Feinberg MW, Hsieh CM, Haber E, Lee ME. Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 2001 Aug; 15(10):1774-6. PMID: 11481226.
    View in: PubMed
  19. Zhao D, Letterman J, Schreiber BM. beta-Migrating very low density lipoprotein (beta VLDL) activates smooth muscle cell mitogen-activated protein (MAP) kinase via G protein-coupled receptor-mediated transactivation of the epidermal growth factor (EGF) receptor: effect of MAP kinase activation on beta VLDL plus EGF-induced cell proliferation. J Biol Chem. 2001 Aug 17; 276(33):30579-88. PMID: 11375998.
    View in: PubMed
  20. Chung TF, Sipe JD, McKee A, Fine RE, Schreiber BM, Liang JS, Johnson RJ. Serum amyloid A in Alzheimer's disease brain is predominantly localized to myelin sheaths and axonal membrane. Amyloid. 2000 Jun; 7(2):105-10. PMID: 10842712.
    View in: PubMed
  21. Schreiber BM, Veverbrants M, Fine RE, Blusztajn JK, Salmona M, Patel A, Sipe JD. Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis. Biochem J. 1999 Nov 15; 344 Pt 1:7-13. PMID: 10548527.
    View in: PubMed
  22. Hsiao H, Stone PJ, Toselli P, Rosenbloom J, Franzblau C, Schreiber BM. The role of the carboxy terminus of tropoelastin in its assembly into the elastic fiber. Connect Tissue Res. 1999; 40(2):83-95. PMID: 10761633.
    View in: PubMed
  23. Shanmugaratnam J, Berg E, Kimerer L, Johnson RJ, Amaratunga A, Schreiber BM, Fine RE. Retinal Muller glia secrete apolipoproteins E and J which are efficiently assembled into lipoprotein particles. Brain Res Mol Brain Res. 1997 Oct 15; 50(1-2):113-20. PMID: 9406925.
    View in: PubMed
  24. Kumon Y, Sipe JD, Brinckerhoff CE, Schreiber BM. Regulation of extrahepatic apolipoprotein serum amyloid A (ApoSAA) gene expression by interleukin-1 alpha alone: synthesis and secretion of ApoSAA by cultured aortic smooth muscle cells. Scand J Immunol. 1997 Sep; 46(3):284-91. PMID: 9315118.
    View in: PubMed
  25. Liang JS, Schreiber BM, Salmona M, Phillip G, Gonnerman WA, de Beer FC, Sipe JD. Amino terminal region of acute phase, but not constitutive, serum amyloid A (apoSAA) specifically binds and transports cholesterol into aortic smooth muscle and HepG2 cells. J Lipid Res. 1996 Oct; 37(10):2109-16. PMID: 8906588.
    View in: PubMed
  26. Amaratunga A, Abraham CR, Edwards RB, Sandell JH, Schreiber BM, Fine RE. Apolipoprotein E is synthesized in the retina by Müller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells. J Biol Chem. 1996 Mar 8; 271(10):5628-32. PMID: 8621425.
    View in: PubMed
  27. Schreiber BM, Jones HV, Franzblau C. Apolipoprotein E expression in aortic smooth muscle cells: the effect of beta VLDL. J Lipid Res. 1994 Jul; 35(7):1177-86. PMID: 7964179.
    View in: PubMed
  28. Schreiber BM, Layne MD, Modest EJ. Superoxide production by macrophages stimulated in vivo with synthetic ether lipids. Lipids. 1994 Apr; 29(4):237-42. PMID: 8177017.
    View in: PubMed
  29. Schreiber BM, Jones HV, Toselli P, Franzblau C. Long-term treatment of neonatal aortic smooth muscle cells with beta VLDL induces cholesterol accumulation. Atherosclerosis. 1992 Aug; 95(2-3):201-10. PMID: 1418093.
    View in: PubMed
  30. Wolfe BL, Schreiber BM, Bryan-Rhadfi J, Stone PJ, Franzblau C. Alterations of tropoelastin biosynthesis by elastase damage to smooth muscle cell matrices. Matrix. 1992 Apr; 12(2):163-71. PMID: 1603039.
    View in: PubMed
  31. Faris B, Jackson LE, Schreiber BM, Martin BM, Jones HV, Franzblau C. A controlled precursor add-back model of elastogenesis in smooth muscle cell cultures. Matrix. 1991 Nov; 11(5):367-72. PMID: 1811167.
    View in: PubMed
  32. Schreiber BM, Martin BM, Hollander W, Franzblau C. beta-VLDL-induced alterations in growth potentiating activity produced by mononuclear phagocytes. Atherosclerosis. 1988 Jan; 69(1):69-79. PMID: 3355608.
    View in: PubMed
  33. Moolten FL, Schreiber BM, Zajdel SH. Antibodies conjugated to potent cytotoxins as specific antitumor agents. Immunol Rev. 1982; 62:47-73. PMID: 6804366.
    View in: PubMed
  34. Moolten FL, Schreiber B, Rizzone A, Weiss AJ, Boger E. Protection of mice against 7,12-dimethylbenz(a)anthracene-induced skin tumors by immunization with a fluorinated analog of the carcinogen. Cancer Res. 1981 Feb; 41(2):425-9. PMID: 6778608.
    View in: PubMed
  35. Moolten FL, Schreiber B. Formation of adherent monolayers of murine lymphocytes in vitro: the use of serum-free medium and concanavalin A-coated surfaces to promote adherence. J Immunol Methods. 1980; 36(3-4):359-68. PMID: 7430658.
    View in: PubMed
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