Keywords
Last Name

Phillip J. Stone, PhD

TitleEmeritus Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-4131
Other Positions
TitleAssistant Dean
InstitutionBoston University School of Medicine
DepartmentAdmissions

TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pessolano LG, Sullivan CP, Seidl SE, Rich CB, Liscum L, Stone PJ, Sipe JD, Schreiber BM. Trafficking of endogenous smooth muscle cell cholesterol: a role for serum amyloid A and interleukin-1ß. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2741-50. PMID: 22995521.
    View in: PubMed
  2. Isenberg BC, Backman DE, Kinahan ME, Jesudason R, Suki B, Stone PJ, Davis EC, Wong JY. Micropatterned cell sheets with defined cell and extracellular matrix orientation exhibit anisotropic mechanical properties. J Biomech. 2012 Mar 15; 45(5):756-61. PMID: 22177672.
    View in: PubMed
  3. Guarnieri F, Spencer JL, Lucey EC, Nugent MA, Stone PJ. A human surfactant peptide-elastase inhibitor construct as a treatment for emphysema. Proc Natl Acad Sci U S A. 2010 Jun 8; 107(23):10661-6. PMID: 20534582.
    View in: PubMed
  4. Zhao Y, Chen L, Gao S, Toselli P, Stone P, Li W. The critical role of the cellular thiol homeostasis in cadmium perturbation of the lung extracellular matrix. Toxicology. 2010 Jan 12; 267(1-3):60-9. PMID: 19879314.
    View in: PubMed
  5. Ritter MC, Jesudason R, Majumdar A, Stamenovic D, Buczek-Thomas JA, Stone PJ, Nugent MA, Suki B. A zipper network model of the failure mechanics of extracellular matrices. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1081-6. PMID: 19144920.
    View in: PubMed
  6. Black LD, Allen PG, Morris SM, Stone PJ, Suki B. Mechanical and failure properties of extracellular matrix sheets as a function of structural protein composition. Biophys J. 2008 Mar 1; 94(5):1916-29. PMID: 17993498.
    View in: PubMed
  7. Gao S, Zhao Y, Kong L, Toselli P, Chou IN, Stone P, Li W. Cloning and characterization of the rat lysyl oxidase gene promoter: identification of core promoter elements and functional nuclear factor I-binding sites. J Biol Chem. 2007 Aug 31; 282(35):25322-37. PMID: 17597074.
    View in: PubMed
  8. Chou DK, Zhao Y, Gao S, Chou IN, Toselli P, Stone P, Li W. Perturbation of copper (Cu) homeostasis and expression of Cu-binding proteins in cadmium-resistant lung fibroblasts. Toxicol Sci. 2007 Sep; 99(1):267-76. PMID: 17584760.
    View in: PubMed
  9. Spencer JL, Stone PJ, Nugent MA. New insights into the inhibition of human neutrophil elastase by heparin. Biochemistry. 2006 Aug 1; 45(30):9104-20. PMID: 16866356.
    View in: PubMed
  10. DiCamillo SJ, Yang S, Panchenko MV, Toselli PA, Naggar EF, Rich CB, Stone PJ, Nugent MA, Panchenko MP. Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2006 Aug; 291(2):L232-43. PMID: 16473861.
    View in: PubMed
  11. Zhao Y, Gao S, Chou IN, Toselli P, Stone P, Li W. Inhibition of the expression of lysyl oxidase and its substrates in cadmium-resistant rat fetal lung fibroblasts. Toxicol Sci. 2006 Apr; 90(2):478-89. PMID: 16432278.
    View in: PubMed
  12. Berk JL, Hatch CA, Morris SM, Stone PJ, Goldstein RH. Hypoxia suppresses elastin repair by rat lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2005 Dec; 289(6):L931-6. PMID: 16055482.
    View in: PubMed
  13. Gao S, Chen K, Zhao Y, Rich CB, Chen L, Li SJ, Toselli P, Stone P, Li W. Transcriptional and posttranscriptional inhibition of lysyl oxidase expression by cigarette smoke condensate in cultured rat fetal lung fibroblasts. Toxicol Sci. 2005 Sep; 87(1):197-203. PMID: 15933228.
    View in: PubMed
  14. Leach JB, Wolinsky JB, Stone PJ, Wong JY. Crosslinked alpha-elastin biomaterials: towards a processable elastin mimetic scaffold. Acta Biomater. 2005 Mar; 1(2):155-64. PMID: 16701792.
    View in: PubMed
  15. Black LD, Brewer KK, Morris SM, Schreiber BM, Toselli P, Nugent MA, Suki B, Stone PJ. Effects of elastase on the mechanical and failure properties of engineered elastin-rich matrices. J Appl Physiol (1985). 2005 Apr; 98(4):1434-41. PMID: 15640390.
    View in: PubMed
  16. Hofmann CS, Wang X, Sullivan CP, Toselli P, Stone PJ, McLean SE, Mecham RP, Schreiber BM, Sonenshein GE. B-Myb represses elastin gene expression in aortic smooth muscle cells. J Biol Chem. 2005 Mar 4; 280(9):7694-701. PMID: 15615710.
    View in: PubMed
  17. Chen LJ, Zhao Y, Gao S, Chou IN, Toselli P, Stone P, Li W. Downregulation of lysyl oxidase and upregulation of cellular thiols in rat fetal lung fibroblasts treated with cigarette smoke condensate. Toxicol Sci. 2005 Feb; 83(2):372-9. PMID: 15509664.
    View in: PubMed
  18. Jones MR, Zhao Z, Sullivan CP, Schreiber BM, Stone PJ, Toselli PA, Kagan HM, Cohen RA, Ravid K. A(3) adenosine receptor deficiency does not influence atherogenesis. J Cell Biochem. 2004 Aug 1; 92(5):1034-43. PMID: 15258925.
    View in: PubMed
  19. Hofmann CS, Sullivan CP, Jiang HY, Stone PJ, Toselli P, Reis ED, Chereshnev I, Schreiber BM, Sonenshein GE. B-Myb represses vascular smooth muscle cell collagen gene expression and inhibits neointima formation after arterial injury. Arterioscler Thromb Vasc Biol. 2004 Sep; 24(9):1608-13. PMID: 15256398.
    View in: PubMed
  20. Buczek-Thomas JA, Lucey EC, Stone PJ, Chu CL, Rich CB, Carreras I, Goldstein RH, Foster JA, Nugent MA. Elastase mediates the release of growth factors from lung in vivo. Am J Respir Cell Mol Biol. 2004 Sep; 31(3):344-50. PMID: 15191913.
    View in: PubMed
  21. Rich CB, Carreras I, Lucey EC, Jaworski JA, Buczek-Thomas JA, Nugent MA, Stone P, Foster JA. Transcriptional regulation of pulmonary elastin gene expression in elastase-induced injury. Am J Physiol Lung Cell Mol Physiol. 2003 Aug; 285(2):L354-62. PMID: 12679320.
    View in: PubMed
  22. Buczek-Thomas JA, Chu CL, Rich CB, Stone PJ, Foster JA, Nugent MA. Heparan sulfate depletion within pulmonary fibroblasts: implications for elastogenesis and repair. J Cell Physiol. 2002 Sep; 192(3):294-303. PMID: 12124775.
    View in: PubMed
  23. DiCamillo SJ, Carreras I, Panchenko MV, Stone PJ, Nugent MA, Foster JA, Panchenko MP. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. J Biol Chem. 2002 May 24; 277(21):18938-46. PMID: 11889128.
    View in: PubMed
  24. Stone PJ, Morris SM, Griffin S, Mithieux S, Weiss AS. Building Elastin. Incorporation of recombinant human tropoelastin into extracellular matrices using nonelastogenic rat-1 fibroblasts as a source for lysyl oxidase. Am J Respir Cell Mol Biol. 2001 Jun; 24(6):733-9. PMID: 11415939.
    View in: PubMed
  25. Gottlieb DJ, Luisetti M, Stone PJ, Allegra L, Cantey-Kiser JM, Grassi C, Snider GL. Short-term supplementation therapy does not affect elastin degradation in severe alpha(1)-antitrypsin deficiency. The American-Italian AATD Study Group. Am J Respir Crit Care Med. 2000 Dec; 162(6):2069-72. PMID: 11112116.
    View in: PubMed
  26. Stone PJ. Potential use of collagen and elastin degradation markers for monitoring liver fibrosis in schistosomiasis. Acta Trop. 2000 Oct 23; 77(1):97-9. PMID: 10996125.
    View in: PubMed
  27. Perrin S, Rich CB, Morris SM, Stone PJ, Foster JA. The zebrafish swimbladder: A simple model for lung elastin injury and repair. Connect Tissue Res. 1999; 40(2):105-12. PMID: 10761635.
    View in: PubMed
  28. Hsiao H, Stone PJ, Toselli P, Rosenbloom J, Franzblau C, Schreiber BM. The role of the carboxy terminus of tropoelastin in its assembly into the elastic fiber. Connect Tissue Res. 1999; 40(2):83-95. PMID: 10761633.
    View in: PubMed
  29. Lucey EC, Goldstein RH, Stone PJ, Snider GL. Remodeling of alveolar walls after elastase treatment of hamsters. Results of elastin and collagen mRNA in situ hybridization. Am J Respir Crit Care Med. 1998 Aug; 158(2):555-64. PMID: 9700135.
    View in: PubMed
  30. Stone PJ, Beiser A, Gottlieb DJ. Circadian variation of urinary excretion of elastin and collagen crosslinks. Proc Soc Exp Biol Med. 1998 Jul; 218(3):229-33. PMID: 9648941.
    View in: PubMed
  31. Morris SM, Thomas KM, Rich CB, Stone PJ. Degradation and repair of elastic fibers in rat lung interstitial fibroblast cultures. Anat Rec. 1998 Apr; 250(4):397-407. PMID: 9566529.
    View in: PubMed
  32. Afdhal NH, Keaveny AP, Cohen SB, Nunes DP, Maldonado N, O'Brien M, Stone PJ. Urinary assays for desmosine and hydroxylysylpyridinoline in the detection of cirrhosis. J Hepatol. 1997 Dec; 27(6):993-1002. PMID: 9453424.
    View in: PubMed
  33. Stone PJ, Morris SM, Thomas KM, Schuhwerk K, Mitchelson A. Repair of elastase-digested elastic fibers in acellular matrices by replating with neonatal rat-lung lipid interstitial fibroblasts or other elastogenic cell types. Am J Respir Cell Mol Biol. 1997 Sep; 17(3):289-301. PMID: 9308916.
    View in: PubMed
  34. Stone PJ, Lucey EC, Snider GL, Franzblau C. Distribution of elastin in hamsters and the turnover rates of different elastin pools. Proc Soc Exp Biol Med. 1997 May; 215(1):94-101. PMID: 9142143.
    View in: PubMed
  35. Gottlieb DJ, Stone PJ, Sparrow D, Gale ME, Weiss ST, Snider GL, O'Connor GT. Urinary desmosine excretion in smokers with and without rapid decline of lung function: the Normative Aging Study. Am J Respir Crit Care Med. 1996 Nov; 154(5):1290-5. PMID: 8912738.
    View in: PubMed
  36. Morris SM, Stone PJ. Immunocytochemical study of the degradation of elastic fibers in a living extracellular matrix. J Histochem Cytochem. 1995 Nov; 43(11):1145-53. PMID: 7560897.
    View in: PubMed
  37. Stone PJ, Franzblau C. Increase in urinary desmosine and pyridinoline during postpartum involution of the uterus in humans. Proc Soc Exp Biol Med. 1995 Oct; 210(1):39-42. PMID: 7675796.
    View in: PubMed
  38. Stone PJ, Konstan MW, Berger M, Dorkin HL, Franzblau C, Snider GL. Elastin and collagen degradation products in urine of patients with cystic fibrosis. Am J Respir Crit Care Med. 1995 Jul; 152(1):157-62. PMID: 7599816.
    View in: PubMed
  39. Stone PJ, Korn JH, North H, Lally EV, Miller LC, Tucker LB, Strongwater S, Snider GL, Franzblau C. Cross-linked elastin and collagen degradation products in the urine of patients with scleroderma. Arthritis Rheum. 1995 Apr; 38(4):517-24. PMID: 7718005.
    View in: PubMed
  40. Stone PJ, Gottlieb DJ, O'Connor GT, Ciccolella DE, Breuer R, Bryan-Rhadfi J, Shaw HA, Franzblau C, Snider GL. Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1995 Apr; 151(4):952-9. PMID: 7697272.
    View in: PubMed
  41. Stone PJ, Morris TA, Franzblau C, Snider GL. Preliminary evidence that augmentation therapy diminishes degradation of cross-linked elastin in alpha-1-antitrypsin-deficient humans. Respiration. 1995; 62(2):76-9. PMID: 7784713.
    View in: PubMed
  42. Stone PJ, Lucey EC, Snider GL, Franzblau C. Effect of diet on urinary excretion of desmosine and hydroxylysyl pyridinoline. Am J Respir Crit Care Med. 1994 Jan; 149(1):174-7. PMID: 8111578.
    View in: PubMed
  43. Stone PJ, Campistol JM, Abraham CR, Rodgers O, Shirahama T, Skinner M. Neutrophil proteases associated with amyloid fibrils. Biochem Biophys Res Commun. 1993 Nov 30; 197(1):130-6. PMID: 8250917.
    View in: PubMed
  44. Morris SM, Stone PJ, Snider GL. Electron microscopic study of human lung tissue after in vitro exposure to elastase. J Histochem Cytochem. 1993 Jun; 41(6):851-66. PMID: 8315277.
    View in: PubMed
  45. Stone PJ, Lucey EC, Breuer R, Christensen TG, Zaslow MC, Clark RA, Franzblau C, Snider GL. Oxidants from neutrophil myeloperoxidase do not enhance elastase-induced emphysema in the hamster. Respiration. 1993; 60(3):137-43. PMID: 8210717.
    View in: PubMed
  46. Stone PJ, Bryan-Rhadfi J, Shaw HA, Franzblau C. Isolation of hydroxylysyl pyridinoline, a mature collagen crosslink from neonatal rat aorta smooth muscle cell cultures. Matrix. 1992 Nov; 12(5):381-7. PMID: 1484505.
    View in: PubMed
  47. Stone PJ, Lucey EC, Noskova D, Digenis GA, Snider GL. Covalently linking a peptidyl carbamate elastase inhibitor to a hydrophilic polymer increases its effectiveness in preventing emphysema and secretory cell metaplasia in the hamster. Am Rev Respir Dis. 1992 Aug; 146(2):457-61. PMID: 1489140.
    View in: PubMed
  48. Wolfe BL, Schreiber BM, Bryan-Rhadfi J, Stone PJ, Franzblau C. Alterations of tropoelastin biosynthesis by elastase damage to smooth muscle cell matrices. Matrix. 1992 Apr; 12(2):163-71. PMID: 1603039.
    View in: PubMed
  49. Stone PJ, Bryan-Rhadfi J, Lucey EC, Ciccolella DE, Crombie G, Faris B, Snider GL, Franzblau C. Measurement of urinary desmosine by isotope dilution and high performance liquid chromatography. Correlation between elastase-induced air-space enlargement in the hamster and elevation of urinary desmosine. Am Rev Respir Dis. 1991 Aug; 144(2):284-90. PMID: 1859049.
    View in: PubMed
  50. Snider GL, Ciccolella DE, Morris SM, Stone PJ, Lucey EC. Putative role of neutrophil elastase in the pathogenesis of emphysema. Ann N Y Acad Sci. 1991; 624:45-59. PMID: 2064248.
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  51. Stone PJ, Lucey EC, Bryan-Rhadfi J, Snider GL, Franzblau C. Isolation of urinary desmosine by HPLC, amino acid analysis, and quantification by isotope dilution. Ann N Y Acad Sci. 1991; 624:355-7. PMID: 2064245.
    View in: PubMed
  52. Christensen TG, Breuer R, Lucey EC, Hornstra LJ, Stone PJ, Snider GL. Lectin cytochemistry reveals differences between hamster trachea and bronchus in the composition of epithelial surface glycoconjugates and in the response of secretory cells to neutrophil elastase. Am J Respir Cell Mol Biol. 1990 Jul; 3(1):61-9. PMID: 2363936.
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  53. Stone PJ, Lucey EC, Virca GD, Christensen TG, Breuer R, Snider GL. Alpha 1-protease inhibitor moderates human neutrophil elastase-induced emphysema and secretory cell metaplasia in hamsters. Eur Respir J. 1990 Jun; 3(6):673-8. PMID: 2379577.
    View in: PubMed
  54. Stone PJ. Degradation of extracellular matrix proteoglycans by human neutrophils. Am J Respir Cell Mol Biol. 1990 Jun; 2(6):491-2. PMID: 2189455.
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  55. Lucey EC, Stone PJ, Ciccolella DE, Breuer R, Christensen TG, Thompson RC, Snider GL. Recombinant human secretory leukocyte-protease inhibitor: in vitro properties, and amelioration of human neutrophil elastase-induced emphysema and secretory cell metaplasia in the hamster. J Lab Clin Med. 1990 Feb; 115(2):224-32. PMID: 2299266.
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  56. Stone PJ, Lucey EC, Snider GL. Induction and exacerbation of emphysema in hamsters with human neutrophil elastase inactivated reversibly by a peptide boronic acid. Am Rev Respir Dis. 1990 Jan; 141(1):47-52. PMID: 2297186.
    View in: PubMed
  57. Christensen TG, Breuer R, Lucey EC, Stone PJ, Snider GL. Regional difference in airway epithelial response to neutrophil elastase: tracheal secretory cells discharge and recover in hamsters that develop bronchial secretory-cell metaplasia. Exp Lung Res. 1989 Dec; 15(6):943-59. PMID: 2612449.
    View in: PubMed
  58. Lucey EC, Stone PJ, Powers JC, Snider GL. Amelioration of human neutrophil elastase-induced emphysema in hamsters by pretreatment with an oligopeptide chloromethyl ketone. Eur Respir J. 1989 May; 2(5):421-7. PMID: 2759224.
    View in: PubMed
  59. Breuer R, Christensen TG, Niles RM, Stone PJ, Snider GL. Human neutrophil elastase causes glycoconjugate release from the epithelial cell surface of hamster trachea in organ culture. Am Rev Respir Dis. 1989 Mar; 139(3):779-82. PMID: 2923377.
    View in: PubMed
  60. Stone PJ, Morris SM, Martin BM, McMahon MP, Faris B, Franzblau C. Repair of protease-damaged elastin in neonatal rat aortic smooth muscle cell cultures. J Clin Invest. 1988 Nov; 82(5):1644-54. PMID: 3141480.
    View in: PubMed
  61. Snider GL, Lucey EC, Faris B, Jung-Legg Y, Stone PJ, Franzblau C. Cadmium-chloride-induced air-space enlargement with interstitial pulmonary fibrosis is not associated with destruction of lung elastin. Implications for the pathogenesis of human emphysema. Am Rev Respir Dis. 1988 Apr; 137(4):918-23. PMID: 3355000.
    View in: PubMed
  62. Stone PJ, Lucey EC, Calore JD, McMahon MP, Snider GL, Franzblau C. Defenses of the hamster lung against human neutrophil and porcine pancreatic elastase. Respiration. 1988; 54(1):1-15. PMID: 2469116.
    View in: PubMed
  63. Kim KC, Wasano K, Niles RM, Schuster JE, Stone PJ, Brody JS. Human neutrophil elastase releases cell surface mucins from primary cultures of hamster tracheal epithelial cells. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):9304-8. PMID: 3480544.
    View in: PubMed
  64. Stone PJ, McMahon MP, Morris SM, Calore JD, Franzblau C. Elastin in a neonatal rat smooth muscle cell culture has greatly decreased susceptibility to proteolysis by human neutrophil elastase. An in vitro model of elastolytic injury. In Vitro Cell Dev Biol. 1987 Oct; 23(10):663-76. PMID: 3667486.
    View in: PubMed
  65. Christensen TG, Breuer R, Hornstra LJ, Lucey EC, Stone PJ, Snider GL. An ultrastructural study of the response of hamster bronchial epithelium to human neutrophil elastase. Exp Lung Res. 1987; 13(3):279-97. PMID: 3691410.
    View in: PubMed
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