Keywords
Last Name

Katya Ravid, DSc

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionCardiovascular Medicine
Address700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Phone(617) 638-5053
ORCID ORCID Icon0000-0002-9918-3024
Other Positions
TitleProfessor
InstitutionBoston University School of Medicine
DepartmentBiochemistry

TitleDirector
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionEvans Center for Interdisciplinary Biomedical Research

TitleDirector
InstitutionBoston University
DepartmentBU Interdisciplinary Biomedical Research Office

TitleDirector, Master of Science Program in Biomedical Research
InstitutionBoston University School of Medicine
DepartmentMedicine

TitleMentor for Graduate Medical Students
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

TitleCenter Faculty Member
InstitutionBoston University School of Medicine
DepartmentCardiovascular Institute (Whitaker)

 Awards and Honors

Start-EndDescription
1982Technion: Gutwirth Prize for Outstanding Graduate Students
1987Weizmann Institute: Weizmann Postdoctoral Fellowship Award
1997American Heart Association: Grant-In-Aid Award for Young Investigators
2000-2005American Heart Association: Established Investigator Award
2006Boston University School of Medicine : Educator of the Year Award, Graduate Medical Sciences
2009University of Sydney : International Visiting Professor Fellowship Award
2013Boston University School of Medicine: Robert Dawson Evans Special Recognition Teaching Award
2014Weizmann Institute: Weizmann Institute Professorship Award
2014American Association for the Advancement of Science: Elected Fellow
2013-2016American Society of Hematology: Chair, Thrombosis and Vascular Biology Scientific Committee
2011-2013Gordon Research Conference-Cell Biology of Megakaryocytes and Platelets: Vice Chair & Chair
2016Fulbright : Fulbright Research Scholar Award
2016-2017Aarhus University, Denmark : International Advisory Board
 Research Expertise & Professional Interests
Platelet aggregation plays a central role in thrombosis and hemostasis, which are central to vascular disease. In the platelet lineage, the early committed cells undergo a unique cell cycle leading to the formation of polyploid megakaryocytes prior to their fragmentation into platelets. Our research focuses on mechanisms that regulate lineage commitment and the subsequent steps of cellular maturation of bone marrow cells into polyploid megakaryocytes. We reported that polyploidy also develops in aging vascular cells, and in other cell types under stress, and mechanisms of control of polyploidy and its relevance to disease states are investigated. An ongoing related project involves the molecular characterization of platelet and vascular adenosine receptors, and exploration of their role in cellular function and lineage development. The systems used include primary bone marrow cultures, as well as transgenic and knock out mouse models.

 Self-Described Keywords
  • Adenosine Receptors
  • Blood Cells
  • Cell Cycle Control
  • Hematopoietic Stem Cells
  • Megakaryocyte
  • Platelet
  • Polyploidy
  • Vascular Biology
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Lucero HA, Patterson S, Matsuura S, Ravid K. Quantitative histological image analyses of reticulin fibers in a myelofibrotic mouse. J Biol Methods. 2016; 3(4). PMID: 28008415.
    View in: PubMed
  2. Matsuura S, Patterson S, Lucero H, Leiva O, Grant AK, Herrera VL, Ravid K. In vivo magnetic resonance imaging of a mouse model of myelofibrosis. Blood Cancer J. 2016 Nov 11; 6(11):e497. PMID: 27834941.
    View in: PubMed
  3. Sun Y, Hu W, Yu X, Liu Z, Tarran R, Ravid K, Huang P. Actinin-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression. Biochem J. 2016 Jul 15; 473(14):2179-86. PMID: 27208173.
    View in: PubMed
  4. Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity. Blood. 2016 Mar 17; 127(11):1493-501. PMID: 26755713.
    View in: PubMed
  5. Eisenstein A, Patterson S, Ravid K. The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases. J Cell Physiol. 2015 Dec; 230(12):2891-7. PMID: 25975415.
    View in: PubMed
  6. Cohen HB, Ward A, Hamidzadeh K, Ravid K, Mosser DM. IFN-? Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response. J Immunol. 2015 Oct 15; 195(8):3828-37. PMID: 26355158.
    View in: PubMed
  7. Seo SW, Koeppen M, Bonney S, Gobel M, Thayer M, Harter PN, Ravid K, Eltzschig HK, Mittelbronn M, Walker L, Eckle T. Differential Tissue-Specific Function of Adora2b in Cardioprotection. J Immunol. 2015 Aug 15; 195(4):1732-43. PMID: 26136425.
    View in: PubMed
  8. Jing L, Tamplin OJ, Chen MJ, Deng Q, Patterson S, Kim PG, Durand EM, McNeil A, Green JM, Matsuura S, Ablain J, Brandt MK, Schlaeger TM, Huttenlocher A, Daley GQ, Ravid K, Zon LI. Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. J Exp Med. 2015 May 4; 212(5):649-63. PMID: 25870200.
    View in: PubMed
  9. Xu YX, Ashline D, Liu L, Tassa C, Shaw SY, Ravid K, Layne MD, Reinhold V, Robbins PW. The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis. J Lipid Res. 2015 Feb; 56(2):266-76. PMID: 25528754.
    View in: PubMed
  10. Eisenstein A, Carroll SH, Johnston-Cox H, Farb M, Gokce N, Ravid K. An adenosine receptor-Krüppel-like factor 4 protein axis inhibits adipogenesis. J Biol Chem. 2014 Jul 25; 289(30):21071-81. PMID: 24928509.
    View in: PubMed
  11. Johnston-Cox H, Eisenstein AS, Koupenova M, Carroll S, Ravid K. The macrophage A2B adenosine receptor regulates tissue insulin sensitivity. PLoS One. 2014; 9(6):e98775. PMID: 24892847.
    View in: PubMed
  12. Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK. Expression of concern. Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest. 2014 Jun 2; 124(6):2807. PMID: 24812671.
    View in: PubMed
  13. Koupenova M, Vitseva O, MacKay CR, Beaulieu LM, Benjamin EJ, Mick E, Kurt-Jones EA, Ravid K, Freedman JE. Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis. Blood. 2014 Jul 31; 124(5):791-802. PMID: 24755410.
    View in: PubMed
  14. Eisenstein A, Ravid K. G protein-coupled receptors and adipogenesis: a focus on adenosine receptors. J Cell Physiol. 2014 Apr; 229(4):414-21. PMID: 24114647.
    View in: PubMed
  15. Ravid K. New roads to a megakaryocyte inner territory. Blood. 2014 Feb 6; 123(6):803-4. PMID: 24505065.
    View in: PubMed
  16. Tak E, Ridyard D, Kim JH, Zimmerman M, Werner T, Wang XX, Shabeka U, Seo SW, Christians U, Klawitter J, Moldovan R, Garcia G, Levi M, Haase V, Ravid K, Eltzschig HK, Grenz A. CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy. J Am Soc Nephrol. 2014 Mar; 25(3):547-63. PMID: 24262796.
    View in: PubMed
  17. Cohen HB, Briggs KT, Marino JP, Ravid K, Robson SC, Mosser DM. TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses. Blood. 2013 Sep 12; 122(11):1935-45. PMID: 23908469.
    View in: PubMed
  18. Ravid K, Wolozin B. The Scientist's Pledge. Acad Med. 2013 Jun; 88(6):743. PMID: 23708595.
    View in: PubMed
  19. Sher N, Von Stetina JR, Bell GW, Matsuura S, Ravid K, Orr-Weaver TL. Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells. Proc Natl Acad Sci U S A. 2013 Jun 4; 110(23):9368-73. PMID: 23613587.
    View in: PubMed
  20. Eckle T, Hughes K, Ehrentraut H, Brodsky KS, Rosenberger P, Choi DS, Ravid K, Weng T, Xia Y, Blackburn MR, Eltzschig HK. Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury. FASEB J. 2013 Aug; 27(8):3078-89. PMID: 23603835.
    View in: PubMed
  21. Eliades A, Papadantonakis N, Matsuura S, Mi R, Bais MV, Trackman P, Ravid K. Megakaryocyte polyploidy is inhibited by lysyl oxidase propeptide. Cell Cycle. 2013 Apr 15; 12(8):1242-50. PMID: 23518500.
    View in: PubMed
  22. Koupenova M, Ravid K. Adenosine, adenosine receptors and their role in glucose homeostasis and lipid metabolism. J Cell Physiol. 2013 Mar 4. PMID: 23460239.
    View in: PubMed
  23. Carroll SH, Ravid K. Differentiation of mesenchymal stem cells to osteoblasts and chondrocytes: a focus on adenosine receptors. Expert Rev Mol Med. 2013; 15:e1. PMID: 23406574.
    View in: PubMed
  24. Ravid K, Faux R, Corkey B, Coleman D. Building interdisciplinary biomedical research using novel collaboratives. Acad Med. 2013 Feb; 88(2):179-84. PMID: 23269301.
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  25. Coleman DL, Spira A, Ravid K. Promoting interdisciplinary research in departments of medicine: results from two models at Boston University School of Medicine. Trans Am Clin Climatol Assoc. 2013; 124:275-82. PMID: 23874035.
    View in: PubMed
  26. Eliades A, Matsuura S, Ravid K. Oxidases and reactive oxygen species during hematopoiesis: a focus on megakaryocytes. J Cell Physiol. 2012 Oct; 227(10):3355-62. PMID: 22331622.
    View in: PubMed
  27. Koupenova M, Johnston-Cox H, Ravid K. Regulation of atherosclerosis and associated risk factors by adenosine and adenosine receptors. Curr Atheroscler Rep. 2012 Oct; 14(5):460-8. PMID: 22850979.
    View in: PubMed
  28. Johnston-Cox H, Koupenova M, Yang D, Corkey B, Gokce N, Farb MG, LeBrasseur N, Ravid K. The A2b adenosine receptor modulates glucose homeostasis and obesity. PLoS One. 2012; 7(7):e40584. PMID: 22848385.
    View in: PubMed
  29. Sun Y, Duan Y, Eisenstein AS, Hu W, Quintana A, Lam WK, Wang Y, Wu Z, Ravid K, Huang P. A novel mechanism of control of NF?B activation and inflammation involving A2B adenosine receptors. J Cell Sci. 2012 Oct 1; 125(Pt 19):4507-17. PMID: 22767505.
    View in: PubMed
  30. Papadantonakis N, Matsuura S, Ravid K. Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection. Blood. 2012 Aug 30; 120(9):1774-81. PMID: 22767499.
    View in: PubMed
  31. Rudich N, Ravid K, Sagi-Eisenberg R. Mast cell adenosine receptors function: a focus on the a3 adenosine receptor and inflammation. Front Immunol. 2012; 3:134. PMID: 22675325.
    View in: PubMed
  32. Johnston-Cox HA, Koupenova M, Ravid K. A2 adenosine receptors and vascular pathologies. Arterioscler Thromb Vasc Biol. 2012 Apr; 32(4):870-8. PMID: 22423039.
    View in: PubMed
  33. Carroll SH, Wigner NA, Kulkarni N, Johnston-Cox H, Gerstenfeld LC, Ravid K. A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo. J Biol Chem. 2012 May 4; 287(19):15718-27. PMID: 22403399.
    View in: PubMed
  34. Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK. Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest. 2012 Feb 1; 122(2):693-710. PMID: 22269324.
    View in: PubMed
  35. Kataoka S, Baquero A, Yang D, Shultz N, Vandenbeuch A, Ravid K, Kinnamon SC, Finger TE. A2BR adenosine receptor modulates sweet taste in circumvallate taste buds. PLoS One. 2012; 7(1):e30032. PMID: 22253866.
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  36. Koupenova M, Johnston-Cox H, Vezeridis A, Gavras H, Yang D, Zannis V, Ravid K. A2b adenosine receptor regulates hyperlipidemia and atherosclerosis. Circulation. 2012 Jan 17; 125(2):354-63. PMID: 22144568.
    View in: PubMed
  37. van der Hoeven D, Wan TC, Gizewski ET, Kreckler LM, Maas JE, Van Orman J, Ravid K, Auchampach JA. A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils. J Pharmacol Exp Ther. 2011 Sep; 338(3):1004-12. PMID: 21693629.
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  38. Eliades A, Papadantonakis N, Bhupatiraju A, Burridge KA, Johnston-Cox HA, Migliaccio AR, Crispino JD, Lucero HA, Trackman PC, Ravid K. Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase. J Biol Chem. 2011 Aug 5; 286(31):27630-8. PMID: 21665949.
    View in: PubMed
  39. Chen H, Koupenova M, Yang D, Sume SS, Trackman PC, Ravid K. Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-a signaling. Exp Hematol. 2011 May; 39(5):525-30. PMID: 21320567.
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  40. Johnston-Cox HA, Ravid K. Adenosine and blood platelets. Purinergic Signal. 2011 Sep; 7(3):357-65. PMID: 21484090.
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  41. Figler RA, Wang G, Srinivasan S, Jung DY, Zhang Z, Pankow JS, Ravid K, Fredholm B, Hedrick CC, Rich SS, Kim JK, LaNoue KF, Linden J. Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans. Diabetes. 2011 Feb; 60(2):669-79. PMID: 21270276.
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  42. Johnston-Cox HA, Yang D, Ravid K. Physiological implications of adenosine receptor-mediated platelet aggregation. J Cell Physiol. 2011 Jan; 226(1):46-51. PMID: 20717958.
    View in: PubMed
  43. Grimsby JL, Lucero HA, Trackman PC, Ravid K, Kagan HM. Role of lysyl oxidase propeptide in secretion and enzyme activity. J Cell Biochem. 2010 Dec 1; 111(5):1231-43. PMID: 20717923.
    View in: PubMed
  44. Ravid K. The value of a native milieu: mutated non-muscle myosin IIA does lead to thrombocytopenia. J Thromb Haemost. 2010 Oct; 8(10):2241-2. PMID: 20723023.
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  45. McCrann DJ, Ravid K. Survivin localization during endomitosis of high ploidy mouse megakaryocytes. Blood. 2010 Sep 23; 116(12):2192-3. PMID: 20864587.
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  46. Anvari F, Sharma AK, Fernandez LG, Hranjec T, Ravid K, Kron IL, Laubach VE. Tissue-derived proinflammatory effect of adenosine A2B receptor in lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2010 Oct; 140(4):871-7. PMID: 20659747.
    View in: PubMed
  47. Eliades A, Papadantonakis N, Ravid K. New roles for cyclin E in megakaryocytic polyploidization. J Biol Chem. 2010 Jun 11; 285(24):18909-17. PMID: 20392692.
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  48. Yang D, Chen H, Koupenova M, Carroll SH, Eliades A, Freedman JE, Toselli P, Ravid K. A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost. 2010 Apr; 8(4):817-27. PMID: 20102488.
    View in: PubMed
  49. Nguyen HG, Ravid K. Polyploidy: mechanisms and cancer promotion in hematopoietic and other cells. Adv Exp Med Biol. 2010; 676:105-22. PMID: 20687472.
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  50. Genzen JR, Yang D, Ravid K, Bordey A. Activation of adenosine A2B receptors enhances ciliary beat frequency in mouse lateral ventricle ependymal cells. Cerebrospinal Fluid Res. 2009; 6:15. PMID: 19922651.
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  51. Ravid K. MAL: not just a leukemia inducer. Blood. 2009 Nov 5; 114(19):3977-8. PMID: 19892723.
    View in: PubMed
  52. Ravid K. Megakaryocytes survive without survivin. Blood. 2009 Jul 2; 114(1):4. PMID: 19574480.
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  53. McCrann DJ, Eliades A, Makitalo M, Matsuno K, Ravid K. Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy. Blood. 2009 Aug 6; 114(6):1243-9. PMID: 19471020.
    View in: PubMed
  54. Chen H, Yang D, Carroll SH, Eltzschig HK, Ravid K. Activation of the macrophage A2b adenosine receptor regulates tumor necrosis factor-alpha levels following vascular injury. Exp Hematol. 2009 May; 37(5):533-8. PMID: 19375644.
    View in: PubMed
  55. Chandrasekharan BP, Kolachala VL, Dalmasso G, Merlin D, Ravid K, Sitaraman SV, Srinivasan S. Adenosine 2B receptors (A(2B)AR) on enteric neurons regulate murine distal colonic motility. FASEB J. 2009 Aug; 23(8):2727-34. PMID: 19357134.
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  56. Nguyen HG, Makitalo M, Yang D, Chinnappan D, St Hilaire C, Ravid K. Deregulated Aurora-B induced tetraploidy promotes tumorigenesis. FASEB J. 2009 Aug; 23(8):2741-8. PMID: 19332642.
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  57. McCrann DJ, Yang D, Chen H, Carroll S, Ravid K. Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy. Cell Cycle. 2009 Mar 15; 8(6):902-8. PMID: 19221493.
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  58. St Hilaire C, Carroll SH, Chen H, Ravid K. Mechanisms of induction of adenosine receptor genes and its functional significance. J Cell Physiol. 2009 Jan; 218(1):35-44. PMID: 18767039.
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  59. Kintsurashvili E, Shenouda S, Ona D, Ona L, Ahmad S, Ravid K, Gavras I, Gavras H. Hypertension in transgenic mice with brain-selective overexpression of the alpha(2B)-adrenoceptor. Am J Hypertens. 2009 Jan; 22(1):41-5. PMID: 18989257.
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  60. Liu L, Brown D, McKee M, Lebrasseur NK, Yang D, Albrecht KH, Ravid K, Pilch PF. Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab. 2008 Oct; 8(4):310-7. PMID: 18840361.
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  61. St Hilaire C, Koupenova M, Carroll SH, Smith BD, Ravid K. TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4. Biochem Biophys Res Commun. 2008 Oct 24; 375(3):292-6. PMID: 18647598.
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  62. Lucero HA, Ravid K, Grimsby JL, Rich CB, DiCamillo SJ, Mäki JM, Myllyharju J, Kagan HM. Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells. J Biol Chem. 2008 Aug 29; 283(35):24103-17. PMID: 18586678.
    View in: PubMed
  63. Grenz A, Osswald H, Eckle T, Yang D, Zhang H, Tran ZV, Klingel K, Ravid K, Eltzschig HK. The reno-vascular A2B adenosine receptor protects the kidney from ischemia. PLoS Med. 2008 Jun 24; 5(6):e137. PMID: 18578565.
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  64. McCrann DJ, Nguyen HG, Jones MR, Ravid K. Vascular smooth muscle cell polyploidy: an adaptive or maladaptive response? J Cell Physiol. 2008 Jun; 215(3):588-92. PMID: 18181174.
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  65. Papadantonakis N, Makitalo M, McCrann DJ, Liu K, Nguyen HG, Martin G, Patel-Hett S, Italiano JE, Ravid K. Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells. Cell Cycle. 2008 Aug; 7(15):2352-6. PMID: 18677109.
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  66. Kolachala VL, Vijay-Kumar M, Dalmasso G, Yang D, Linden J, Wang L, Gewirtz A, Ravid K, Merlin D, Sitaraman SV. A2B adenosine receptor gene deletion attenuates murine colitis. Gastroenterology. 2008 Sep; 135(3):861-70. PMID: 18601927.
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  67. Ravid K. Platelet marginal bands: not so marginal. Blood. 2008 May 1; 111(9):4423. PMID: 18441237.
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  68. St Hilaire C, Yang D, Schreiber BM, Ravid K. B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells. J Cell Biochem. 2008 Apr 15; 103(6):1962-74. PMID: 17979185.
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  69. Xu Y, Ravid K, Smith BD. Major histocompatibility class II transactivator expression in smooth muscle cells from A2b adenosine receptor knock-out mice: cross-talk between the adenosine and interferon-gamma signaling. J Biol Chem. 2008 May 23; 283(21):14213-20. PMID: 18359773.
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  70. McCrann DJ, Yezefski T, Nguyen HG, Papadantonakis N, Liu H, Wen Q, Crispino JD, Ravid K. Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice. Blood. 2008 Apr 15; 111(8):4092-5. PMID: 18245663.
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  71. Yang D, Koupenova M, McCrann DJ, Kopeikina KJ, Kagan HM, Schreiber BM, Ravid K. The A2b adenosine receptor protects against vascular injury. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):792-6. PMID: 18184815.
    View in: PubMed
  72. Hurtado PA, Vora S, Sume SS, Yang D, St Hilaire C, Guo Y, Palamakumbura AH, Schreiber BM, Ravid K, Trackman PC. Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation. Biochem Biophys Res Commun. 2008 Feb 1; 366(1):156-61. PMID: 18060869.
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  73. Yang D, McCrann DJ, Nguyen H, St Hilaire C, DePinho RA, Jones MR, Ravid K. Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell. 2007 Apr; 6(2):257-60. PMID: 17291294.
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  74. Faenza I, Ramazzotti G, Bavelloni A, Fiume R, Gaboardi GC, Follo MY, Gilmour RS, Martelli AM, Ravid K, Cocco L. Inositide-dependent phospholipase C signaling mimics insulin in skeletal muscle differentiation by affecting specific regions of the cyclin D3 promoter. Endocrinology. 2007 Mar; 148(3):1108-17. PMID: 17122077.
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  75. Hazony Y, Lu J, St Hilaire C, Ravid K. Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature. Nucleic Acids Res. 2006; 34(16):4416-28. PMID: 16936310.
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  76. Nguyen HG, Ravid K. Tetraploidy/aneuploidy and stem cells in cancer promotion: The role of chromosome passenger proteins. J Cell Physiol. 2006 Jul; 208(1):12-22. PMID: 16331679.
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  77. Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest. 2006 Jul; 116(7):1913-23. PMID: 16823489.
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  78. Nguyen HG, Chinnappan D, Urano T, Ravid K. Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property. Mol Cell Biol. 2005 Jun; 25(12):4977-92. PMID: 15923616.
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  79. Nguyen HG, Yu G, Makitalo M, Yang D, Xie HX, Jones MR, Ravid K. Conditional overexpression of transgenes in megakaryocytes and platelets in vivo. Blood. 2005 Sep 1; 106(5):1559-64. PMID: 15890684.
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  80. Nagata Y, Jones MR, Nguyen HG, McCrann DJ, St Hilaire C, Schreiber BM, Hashimoto A, Inagaki M, Earnshaw WC, Todokoro K, Ravid K. Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle. Exp Cell Res. 2005 May 1; 305(2):277-91. PMID: 15817153.
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  81. Yaar R, Jones MR, Chen JF, Ravid K. Animal models for the study of adenosine receptor function. J Cell Physiol. 2005 Jan; 202(1):9-20. PMID: 15389588.
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  82. Jones MR, Zhao Z, Sullivan CP, Schreiber BM, Stone PJ, Toselli PA, Kagan HM, Cohen RA, Ravid K. A(3) adenosine receptor deficiency does not influence atherogenesis. J Cell Biochem. 2004 Aug 1; 92(5):1034-43. PMID: 15258925.
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  83. Zhang Y, Nagata Y, Yu G, Nguyen HG, Jones MR, Toselli P, Jackson CW, Tatsuka M, Todokoro K, Ravid K. Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression. Blood. 2004 May 15; 103(10):3717-26. PMID: 14751927.
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  84. Bernardin-Fried F, Kummalue T, Leijen S, Collector MI, Ravid K, Friedman AD. AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression. J Biol Chem. 2004 Apr 9; 279(15):15678-87. PMID: 14747476.
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  85. Kaluzhny Y, Ravid K. Role of apoptotic processes in platelet biogenesis. Acta Haematol. 2004; 111(1-2):67-77. PMID: 14646346.
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  86. Lu J, Pazin MJ, Ravid K. Properties of ets-1 binding to chromatin and its effect on platelet factor 4 gene expression. Mol Cell Biol. 2004 Jan; 24(1):428-41. PMID: 14673175.
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  87. Jones MR, Ravid K. Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expression. J Biol Chem. 2004 Feb 13; 279(7):5306-13. PMID: 14634004.
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  88. Lu J, Pierron A, Ravid K. An adenosine analogue, IB-MECA, down-regulates estrogen receptor alpha and suppresses human breast cancer cell proliferation. Cancer Res. 2003 Oct 1; 63(19):6413-23. PMID: 14559831.
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  89. Hechler B, Zhang Y, Eckly A, Cazenave JP, Gachet C, Ravid K. Lineage-specific overexpression of the P2Y1 receptor induces platelet hyper-reactivity in transgenic mice. J Thromb Haemost. 2003 Jan; 1(1):155-63. PMID: 12871553.
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  90. Yaar R, Lamperti ED, Toselli PA, Ravid K. Activity of the A3 adenosine receptor gene promoter in transgenic mice: characterization of previously unidentified sites of expression. FEBS Lett. 2002 Dec 18; 532(3):267-72. PMID: 12482577.
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  91. Yaar R, Cataldo LM, Tzatsos A, Francis CE, Zhao Z, Ravid K. Regulation of the A3 adenosine receptor gene in vascular smooth muscle cells: role of a cAMP and GATA element. Mol Pharmacol. 2002 Nov; 62(5):1167-76. PMID: 12391281.
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  92. Kaluzhny Y, Hechler B, Lu J, Nguyen HG, Cataldo LM, Ravid K. A selective effect of Mpl ligand on mRNA stabilization during megakaryocyte differentiation. FEBS Lett. 2002 Sep 11; 527(1-3):279-83. PMID: 12220674.
    View in: PubMed
  93. Kaluzhny Y, Yu G, Sun S, Toselli PA, Nieswandt B, Jackson CW, Ravid K. BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation. Blood. 2002 Sep 1; 100(5):1670-8. PMID: 12176887.
    View in: PubMed
  94. Chinnappan D, Zhang Y, Ravid K. AIM-1 transgenic mice with a curly tail phenotype and its chromosome location. Cytogenet Genome Res. 2002; 98(2-3):231A. PMID: 12698010.
    View in: PubMed
  95. Zhang Y, Sun S, Wang Z, Thompson A, Kaluzhny Y, Zimmet J, Ravid K. Signaling by the Mpl receptor involves IKK and NF-kappaB. J Cell Biochem. 2002; 85(3):523-35. PMID: 11967992.
    View in: PubMed
  96. Zhao Z, Yaar R, Ladd D, Cataldo LM, Ravid K. Overexpression of A3 adenosine receptors in smooth, cardiac, and skeletal muscle is lethal to embryos. Microvasc Res. 2002 Jan; 63(1):61-9. PMID: 11749073.
    View in: PubMed
  97. Ravid K, Lu J, Zimmet JM, Jones MR. Roads to polyploidy: the megakaryocyte example. J Cell Physiol. 2002 Jan; 190(1):7-20. PMID: 11807806.
    View in: PubMed
  98. Hechler B, Toselli P, Ravanat C, Gachet C, Ravid K. Mpl ligand increases P2Y1 receptor gene expression in megakaryocytes with no concomitant change in platelet response to ADP. Mol Pharmacol. 2001 Nov; 60(5):1112-20. PMID: 11641440.
    View in: PubMed
  99. Zhang Y, Sun S, Chen WC, Kaluzhny Y, Chinnappan D, Yu G, Ravid K. Repression of AIM-1 kinase mRNA as part of a program of genes regulated by Mpl ligand. Biochem Biophys Res Commun. 2001 Apr 6; 282(3):844-9. PMID: 11401541.
    View in: PubMed
  100. Sun S, Zimmet JM, Toselli P, Thompson A, Jackson CW, Ravid K. Overexpression of cyclin D1 moderately increases ploidy in megakaryocytes. Haematologica. 2001 Jan; 86(1):17-23. PMID: 11146565.
    View in: PubMed
  101. Zhao Z, Makaritsis K, Francis CE, Gavras H, Ravid K. A role for the A3 adenosine receptor in determining tissue levels of cAMP and blood pressure: studies in knock-out mice. Biochim Biophys Acta. 2000 Mar 17; 1500(3):280-90. PMID: 10699369.
    View in: PubMed
  102. Sun S, Jackson CW, Ravid K. MAP kinase localizes to the platelet-yielding demarcation membrane system in megakaryocytes. Blood. 2000 Feb 15; 95(4):1511. PMID: 10722281.
    View in: PubMed
  103. Zimmet J, Ravid K. Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system. Exp Hematol. 2000 Jan; 28(1):3-16. PMID: 10658672.
    View in: PubMed
  104. Sun S, Ravid K. Role of a serine/threonine kinase, Mst1, in megakaryocyte differentiation. J Cell Biochem. 1999 Nov; 76(1):44-60. PMID: 10581000.
    View in: PubMed
  105. Ravid K, Smith-Mungo LI, Zhao Z, Thomas KM, Kagan HM. Upregulation of lysyl oxidase in vascular smooth muscle cells by cAMP: role for adenosine receptor activation. J Cell Biochem. 1999 Oct 1; 75(1):177-85. PMID: 10462716.
    View in: PubMed
  106. Thompson A, Ravid K. Repression of A TAF(II)32 isoform as part of a program of genes regulated during mpl ligand-induced megakaryocyte differentiation. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):55-9. PMID: 10448067.
    View in: PubMed
  107. Wang Z, Zhang Y, Lu J, Sun S, Ravid K. Mpl ligand enhances the transcription of the cyclin D3 gene: a potential role for Sp1 transcription factor. Blood. 1999 Jun 15; 93(12):4208-21. PMID: 10361118.
    View in: PubMed
  108. Zhao Z, Francis C, Ravid K. Characterization of the mouse A3 adenosine receptor gene: exon/intron organization and promoter activity. Genomics. 1999 Apr 1; 57(1):152-5. PMID: 10191095.
    View in: PubMed
  109. Sun S, Kaluzhny Y, Ravid K. Ectopic expression of the Aspergillus nidulans mitotic inducer, nimA kinase, in megakaryocytes: effect on polyploidization. Exp Hematol. 1999 Apr; 27(4):594-604. PMID: 10210317.
    View in: PubMed
  110. Cataldo LM, Zhang Y, Lu J, Ravid K. Rat NAP1: cDNA cloning and upregulation by Mpl ligand. Gene. 1999 Jan 21; 226(2):355-64. PMID: 9931510.
    View in: PubMed
  111. Zhang Y, Wang Z, Liu DX, Pagano M, Ravid K. Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes. J Biol Chem. 1998 Jan 16; 273(3):1387-92. PMID: 9430673.
    View in: PubMed
  112. Zimmet JM, Toselli P, Ravid K. Cyclin D3 and megakaryocyte development: exploration of a transgenic phenotype. Stem Cells. 1998; 16 Suppl 2:97-106. PMID: 11012182.
    View in: PubMed
  113. Zimmet JM, Ladd D, Jackson CW, Stenberg PE, Ravid K. A role for cyclin D3 in the endomitotic cell cycle. Mol Cell Biol. 1997 Dec; 17(12):7248-59. PMID: 9372957.
    View in: PubMed
  114. Zhao Z, Francis CE, Welch G, Loscalzo J, Ravid K. Reduced glutathione prevents nitric oxide-induced apoptosis in vascular smooth muscle cells. Biochim Biophys Acta. 1997 Nov 27; 1359(2):143-52. PMID: 9409811.
    View in: PubMed
  115. Zhao Z, Francis CE, Ravid K. An A3-subtype adenosine receptor is highly expressed in rat vascular smooth muscle cells: its role in attenuating adenosine-induced increase in cAMP. Microvasc Res. 1997 Nov; 54(3):243-52. PMID: 9441895.
    View in: PubMed
  116. Thompson A, Zhang Y, Kamen D, Jackson CW, Cardiff RD, Ravid K. Deregulated expression of c-myc in megakaryocytes of transgenic mice increases megakaryopoiesis and decreases polyploidization. J Biol Chem. 1996 Sep 20; 271(38):22976-82. PMID: 8798484.
    View in: PubMed
  117. Wang Z, Sicinski P, Weinberg RA, Zhang Y, Ravid K. Characterization of the mouse cyclin D3 gene: exon/intron organization and promoter activity. Genomics. 1996 Jul 1; 35(1):156-63. PMID: 8661116.
    View in: PubMed
  118. Zhang Y, Wang Z, Ravid K. The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin B1-dependent cdc2 kinase. J Biol Chem. 1996 Feb 23; 271(8):4266-72. PMID: 8626773.
    View in: PubMed
  119. Thompson A, Zhao Z, Ladd D, Zimmet J, Ravid K. A new transgenic mouse model for the study of cell cycle control in megakaryocytes. Stem Cells. 1996; 14 Suppl 1:181-7. PMID: 11012219.
    View in: PubMed
  120. Wang Z, Zhang Y, Kamen D, Lees E, Ravid K. Cyclin D3 is essential for megakaryocytopoiesis. Blood. 1995 Nov 15; 86(10):3783-8. PMID: 7579345.
    View in: PubMed
  121. Zhao Z, Ravid S, Ravid K. Chromosomal mapping of the mouse A3 adenosine receptor gene, Adora3. Genomics. 1995 Nov 1; 30(1):118-9. PMID: 8595892.
    View in: PubMed
  122. Ravid K, Kuter DJ, Rosenberg RD. rmIL-6 stimulates the transcriptional activity of the rat PF4 gene. Exp Hematol. 1995 May; 23(5):397-401. PMID: 7720812.
    View in: PubMed
  123. Block KL, Ravid K, Phung QH, Poncz M. Characterization of regulatory elements in the 5'-flanking region of the rat GPIIb gene by studies in a primary rat marrow culture system. Blood. 1994 Nov 15; 84(10):3385-93. PMID: 7949093.
    View in: PubMed
  124. Ravid K, Li YC, Rayburn HB, Rosenberg RD. Targeted expression of a conditional oncogene in hematopoietic cells of transgenic mice. J Cell Biol. 1993 Dec; 123(6 Pt 1):1545-53. PMID: 8253849.
    View in: PubMed
  125. Ravid K, Kuter DJ, Beeler DL, Doi T, Rosenberg RD. Selection of an HEL-derived cell line expressing high levels of platelet factor 4. Blood. 1993 Jun 1; 81(11):2885-90. PMID: 8499627.
    View in: PubMed
  126. Grabarek J, Raychowdhury M, Ravid K, Kent KC, Newman PJ, Ware JA. Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells. J Biol Chem. 1992 May 15; 267(14):10011-7. PMID: 1374394.
    View in: PubMed
  127. Ravid K, Doi T, Beeler DL, Kuter DJ, Rosenberg RD. Transcriptional regulation of the rat platelet factor 4 gene: interaction between an enhancer/silencer domain and the GATA site. Mol Cell Biol. 1991 Dec; 11(12):6116-27. PMID: 1944279.
    View in: PubMed
  128. Ravid K, Beeler DL, Rabin MS, Ruley HE, Rosenberg RD. Selective targeting of gene products with the megakaryocyte platelet factor 4 promoter. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1521-5. PMID: 1899930.
    View in: PubMed
  129. Ravid K, Rosenthal RA, Doctrow SR, Lowenstein JM. 28 kDa adenosine-binding proteins of brain and other tissues. Biochem J. 1989 Mar 15; 258(3):653-61. PMID: 2730563.
    View in: PubMed
  130. Ravid K, Lowenstein JM. Changes in adenosine receptors during differentiation of 3T3-F442A cells to adipocytes. Biochem J. 1988 Jan 15; 249(2):377-81. PMID: 2829856.
    View in: PubMed
  131. Ravid K, Diamant P, Avi-Dor Y. Interrelation between salvage of purine nucleotides and protein synthesis in rat heart cells. Arch Biochem Biophys. 1985 Jan; 236(1):159-66. PMID: 3966790.
    View in: PubMed
  132. Ravid K, Diamant P, Avi-Dor Y. Regulation of the salvage pathway of purine nucleotide synthesis by the oxidation state of NAD+ in rat heart cells. Arch Biochem Biophys. 1984 Mar; 229(2):632-9. PMID: 6200076.
    View in: PubMed
  133. Ravid K, Lavie L, Gershon D. The presence of NADPH-glyceraldehyde 3-phosphate oxidoreductase in macrophages. FEBS Lett. 1983 Oct 3; 162(1):107-11. PMID: 6617882.
    View in: PubMed
  134. Ravid K, Avi-Dor Y. Spectrophotometric determination of cyanide based on the formation of NAD+-cyanide addition compound. Anal Biochem. 1980 Nov 1; 108(2):343-5. PMID: 7457878.
    View in: PubMed
  135. Ravid K, Diamant P, Avi-Dor Y. Glucose-dependent stimulation of protein synthesis in cultured heart muscle cells. Possible involvement of the pentose phosphate pathway. FEBS Lett. 1980 Sep 22; 119(1):20-4. PMID: 6775978.
    View in: PubMed
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