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Doctrow, S.R., Liesa, M., Melov, S., Shirihai, O.S., and Tofilon, P.J. Current Inorg. Chem. (in press). Salen Mn complexes are superoxide dismutase and catalase mimetics that protect the mitochondria. 2012.
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Mahmood J, Jelveh S, Calveley V, Zaidi A, Doctrow SR, Hill RP. Mitigation of lung injury after accidental exposure to radiation. Radiat Res. 2011 Dec; 176(6):770-80. PMID: 22013884; PMCID: PMC3252890
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Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16; 124(7):806-13.View Related Profiles. PMID: 21788586; PMCID: PMC4491919; DOI: 10.1161/CIRCULATIONAHA.110.003418;
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Mahmood J, Jelveh S, Calveley V, Zaidi A, Doctrow SR, Hill RP. Mitigation of radiation-induced lung injury by genistein and EUK-207. Int J Radiat Biol. 2011 Aug; 87(8):889-901. PMID: 21675818; PMCID: PMC3155801; DOI: 10.3109/09553002.2011.583315;
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Rosenthal RA, Fish B, Hill RP, Huffman KD, Lazarova Z, Mahmood J, Medhora M, Molthen R, Moulder JE, Sonis ST, Tofilon PJ, Doctrow SR. Salen Mn complexes mitigate radiation injury in normal tissues. Anticancer Agents Med Chem. 2011 May 1; 11(4):359-72. PMID: 21453241; PMCID: PMC3814176
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Rosenthal RA, Doctrow SR, Callaway WB. Superoxide dismutase mimics. Antioxid Redox Signal. 2011 Mar 15; 14(6):1173; author reply 1174-6. PMID: 21110789; PMCID: PMC3042305; DOI: 10.1089/ars.2010.3758;
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Vorotnikova E, Rosenthal RA, Tries M, Doctrow SR, Braunhut SJ. Novel synthetic SOD/catalase mimetics can mitigate capillary endothelial cell apoptosis caused by ionizing radiation. Radiat Res. 2010 Jun; 173(6):748-59. PMID: 20518654; DOI: 10.1667/RR1948.1;
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Rosenthal RA, Huffman KD, Fisette LW, Damphousse CA, Callaway WB, Malfroy B, Doctrow SR. Orally available Mn porphyrins with superoxide dismutase and catalase activities. J Biol Inorg Chem. 2009 Aug; 14(6):979-91. PMID: 19504132; PMCID: PMC2716445; DOI: 10.1007/s00775-009-0550-4;
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Brazier MW, Doctrow SR, Masters CL, Collins SJ. A manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease. Free Radic Biol Med. 2008 Jul 15; 45(2):184-92. PMID: 18455516; DOI: 10.1016/j.freeradbiomed.2008.04.006;
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Srinivasan V, Doctrow S, Singh VK, Whitnall MH. Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008; 30(2):271-90. PMID: 18569084; DOI: 10.1080/08923970801925331 ;
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Peng J, Peng L, Stevenson FF, Doctrow SR, Andersen JK. Iron and paraquat as synergistic environmental risk factors in sporadic Parkinson's disease accelerate age-related neurodegeneration. J Neurosci. 2007 Jun 27; 27(26):6914-22. PMID: 17596439
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Limoli CL, Giedzinski E, Baure J, Doctrow SR, Rola R, Fike JR. Using superoxide dismutase/catalase mimetics to manipulate the redox environment of neural precursor cells. Radiat Prot Dosimetry. 2006; 122(1-4):228-36. PMID: 17166877
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Zhang HJ, Doctrow SR, Oberley LW, Kregel KC. Chronic antioxidant enzyme mimetic treatment differentially modulates hyperthermia-induced liver HSP70 expression with aging. J Appl Physiol (1985). 2006 Apr; 100(4):1385-91. PMID: 16254069
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Peng J, Stevenson FF, Doctrow SR, Andersen JK. Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease. J Biol Chem. 2005 Aug 12; 280(32):29194-8. PMID: 15946937
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Melov S, Wolf N, Strozyk D, Doctrow SR, Bush AI. Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment. Free Radic Biol Med. 2005 Jan 15; 38(2):258-61. PMID: 15607908
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J. Sessler, S. R. Doctrow, T. McMurry, and S. Lippard (editors). Medicinal Inorganic Chemistry. American Chemical Society Symposium Series. ACS and Oxford University Press. 2005; 453 pages.
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Doctrow, S.R., Baudry, M., Huffman, K., Malfroy, B., and Melov, S. . Salen-manganese complexes: multifunctional catalytic antioxidants protective in models for neurodegenerative diseases of aging. Medicinal Inorganic Chemistry (J. Sessler, S. R. Doctrow, T. McMurry, and S. Lippard, eds). ACS and Oxford University Press. 2005; 319-347.
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Zhang HJ, Doctrow SR, Xu L, Oberley LW, Beecher B, Morrison J, Oberley TD, Kregel KC. Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress. FASEB J. 2004 Oct; 18(13):1547-9. PMID: 15319374
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Friedman JS, Lopez MF, Fleming MD, Rivera A, Martin FM, Welsh ML, Boyd A, Doctrow SR, Burakoff SJ. SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. Blood. 2004 Oct 15; 104(8):2565-73. PMID: 15205258
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Browne SE, Roberts LJ, Dennery PA, Doctrow SR, Beal MF, Barlow C, Levine RL. Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice. Free Radic Biol Med. 2004 Apr 1; 36(7):938-42. PMID: 15019978
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Hinerfeld D, Traini MD, Weinberger RP, Cochran B, Doctrow SR, Harry J, Melov S. Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice. J Neurochem. 2004 Feb; 88(3):657-67. PMID: 14720215
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Liu R, Liu IY, Bi X, Thompson RF, Doctrow SR, Malfroy B, Baudry M. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. Proc Natl Acad Sci U S A. 2003 Jul 8; 100(14):8526-31. PMID: 12815103; PMCID: PMC166262
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Liu R, Liu W, Doctrow SR, Baudry M. Iron toxicity in organotypic cultures of hippocampal slices: role of reactive oxygen species. J Neurochem. 2003 Apr; 85(2):492-502. PMID: 12675926
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Doctrow, S.R., Adinolfi, C., Baudry, M., Huffman, K., Malfroy, B., Marcus, C.B., Melov, S., Pong, K., Rong, Y., Smart, J., and Tocco, G. . Salen manganese complexes, combined superoxide dismutase/catalase mimetics, demonstrate potential for treating neurodegenerative and other age-associated diseases. Critical Reviews in Oxidative Stress and Aging: Advances in Basic Science, Diagnostics, and Intervention. (H. Rodriguez and R. Cutler, eds.). World Scientific Publishing Company. 2003; Chptr 71(Vol I):1324-43.
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Doctrow SR, Huffman K, Marcus CB, Tocco G, Malfroy E, Adinolfi CA, Kruk H, Baker K, Lazarowych N, Mascarenhas J, Malfroy B. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies. J Med Chem. 2002 Sep 26; 45(20):4549-58. PMID: 12238934
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Pong K, Rong Y, Doctrow SR, Baudry M. Attenuation of zinc-induced intracellular dysfunction and neurotoxicity by a synthetic superoxide dismutase/catalase mimetic, in cultured cortical neurons. Brain Res. 2002 Sep 20; 950(1-2):218-30. PMID: 12231247
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Melov S, Doctrow SR, Schneider JA, Haberson J, Patel M, Coskun PE, Huffman K, Wallace DC, Malfroy B. Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J Neurosci. 2001 Nov 1; 21(21):8348-53. PMID: 11606622
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Pong K, Doctrow SR, Huffman K, Adinolfi CA, Baudry M. Attenuation of staurosporine-induced apoptosis, oxidative stress, and mitochondrial dysfunction by synthetic superoxide dismutase and catalase mimetics, in cultured cortical neurons. Exp Neurol. 2001 Sep; 171(1):84-97. PMID: 11520123
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Giblin GM, Box PC, Campbell IB, Hancock AP, Roomans S, Mills GI, Molloy C, Tranter GE, Walker AL, Doctrow SR, Huffman K, Malfroy B. 6,6'-Bis(2-hydroxyphenyl)-2,2'-bipyridine manganese(III) complexes: a novel series of superoxide dismutase and catalase mimetics. Bioorg Med Chem Lett. 2001 Jun 4; 11(11):1367-70. PMID: 11378356
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Jung C, Rong Y, Doctrow S, Baudry M, Malfroy B, Xu Z. Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model. Neurosci Lett. 2001 May 25; 304(3):157-60. PMID: 11343826
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Anderson I, Adinolfi C, Doctrow S, Huffman K, Joy KA, Malfroy B, Soden P, Rupniak HT, Barnes JC. Oxidative signalling and inflammatory pathways in Alzheimer's disease. Biochem Soc Symp. 2001; (67):141-9. PMID: 11447830
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Pong K, Doctrow SR, Baudry M. Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons. Brain Res. 2000 Oct 27; 881(2):182-9. PMID: 11036157
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Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow GJ. Extension of life-span with superoxide dismutase/catalase mimetics. Science. 2000 Sep 1; 289(5484):1567-9. PMID: 10968795
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Rupniak HT, Joy KA, Atkin C, Brown G, Barnes JC, Doctrow SR, Malfroy B, Wong T, Anderson IK, Molloy CR, Mills GI, Soden P. Oxidative neuropathology and putative chemical entities for Alzheimer's disease: neuroprotective effects of salen-manganese catalytic anti-oxidants. Neurotox Res. 2000; 2(2-3):167-78. PMID: 16787839
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Rong Y, Doctrow SR, Tocco G, Baudry M. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9897-902. PMID: 10449791; PMCID: PMC22307
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Gerol M, Curry L, McCarroll L, Doctrow S, RayChaudhury A. Growth regulation of cultured endothelial cells by inflammatory cytokines: mitogenic, anti-proliferative and cytotoxic effects. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Oct; 120(3):397-404. PMID: 9827056
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Baker K, Marcus CB, Huffman K, Kruk H, Malfroy B, Doctrow SR. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther. 1998 Jan; 284(1):215-21. PMID: 9435181
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Gonzalez PK, Doctrow SR, Malfroy B, Fink MP. Role of oxidant stress and iron delocalization in acidosis-induced intestinal epithelial hyperpermeability. Shock. 1997 Aug; 8(2):108-14. PMID: 9261900
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Malfroy B, Doctrow SR, Orr PL, Tocco G, Fedoseyeva EV, Benichou G. Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites. Cell Immunol. 1997 Apr 10; 177(1):62-8. PMID: 9140096
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Cruikshank WW, Doctrow SR, Falvo MS, Huffman K, Maciaszek J, Viglianti G, Raina J, Kornfeld H, Malfroy B. A lipidated anti-Tat antibody enters living cells and blocks HIV-1 viral replication. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Mar 1; 14(3):193-203.View Related Profiles. PMID: 9117450
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Doctrow SR, Huffman K, Marcus CB, Musleh W, Bruce A, Baudry M, Malfroy B. “Salen manganese complexes: combined superoxide dismutase/catalase mimics with broad pharmacological efficacy”. in Antioxidants in Disease Mechanisms and Therapeutic Strategies (H. Sies, ed.). Advances in Pharmacology. 1997; 38:247-269.
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Doctrow SR, Huffman K, Marcus CB, Musleh W, Bruce A, Baudry M, Malfroy B. Salen-manganese complexes: combined superoxide dismutase/catalase mimics with broad pharmacological efficacy. Adv Pharmacol. 1997; 38:247-69. PMID: 8895812
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Jordan T, Walus L, Velickovic A, Last T, Doctrow S, Liu H. A competitive chemiluminescent enzyme-linked immunosorbent assay for the determination of RMP-7 in human blood. J Pharm Biomed Anal. 1996 Sep; 14(12):1653-62. PMID: 8887712
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Gonzalez PK, Zhuang J, Doctrow SR, Malfroy B, Benson PF, Menconi MJ, Fink MP. Role of oxidant stress in the adult respiratory distress syndrome: evaluation of a novel antioxidant strategy in a porcine model of endotoxin-induced acute lung injury. Shock. 1996; 6 Suppl 1:S23-6. PMID: 8828094
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Gonzalez PK, Zhuang J, Doctrow SR, Malfroy B, Benson PF, Menconi MJ, Fink MP. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J Pharmacol Exp Ther. 1995 Nov; 275(2):798-806. PMID: 7473169
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Doctrow SR, Abelleira SM, Curry LA, Heller-Harrison R, Kozarich JW, Malfroy B, McCarroll LA, Morgan KG, Morrow AR, Musso GF, et al. The bradykinin analog RMP-7 increases intracellular free calcium levels in rat brain microvascular endothelial cells. J Pharmacol Exp Ther. 1994 Oct; 271(1):229-37.View Related Profiles. PMID: 7965719
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Höckel M, Schlenger K, Doctrow S, Kissel T, Vaupel P. Therapeutic angiogenesis. Arch Surg. 1993 Apr; 128(4):423-9. PMID: 7681277
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Trippel SB, Wroblewski J, Makower AM, Whelan MC, Schoenfeld D, Doctrow SR. Regulation of growth-plate chondrocytes by insulin-like growth-factor I and basic fibroblast growth factor. J Bone Joint Surg Am. 1993 Feb; 75(2):177-89. PMID: 8423178
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Friden PM, Walus LR, Watson P, Doctrow SR, Kozarich JW, Bäckman C, Bergman H, Hoffer B, Bloom F, Granholm AC. Blood-brain barrier penetration and in vivo activity of an NGF conjugate. Science. 1993 Jan 15; 259(5093):373-7. PMID: 8420006
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Trippel SB, Whelan MC, Klagsbrun M, Doctrow SR. Interaction of basic fibroblast growth factor with bovine growth plate chondrocytes. J Orthop Res. 1992 Sep; 10(5):638-46. PMID: 1323648
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Watson PM, Anderson JM, Vanltallie CM, Doctrow SR. The tight-junction-specific protein ZO-1 is a component of the human and rat blood-brain barriers. Neurosci Lett. 1991 Aug 5; 129(1):6-10. PMID: 1922971
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Kurokawa M, Doctrow SR, Klagsbrun M. Neutralizing antibodies inhibit the binding of basic fibroblast growth factor to its receptor but not to heparin. J Biol Chem. 1989 May 5; 264(13):7686-91. PMID: 2540201
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Ravid K, Rosenthal RA, Doctrow SR, Lowenstein JM. 28 kDa adenosine-binding proteins of brain and other tissues. Biochem J. 1989 Mar 15; 258(3):653-61.View Related Profiles. PMID: 2730563; PMCID: PMC1138416
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Bashkin P, Doctrow S, Klagsbrun M, Svahn CM, Folkman J, Vlodavsky I. Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry. 1989 Feb 21; 28(4):1737-43. PMID: 2541764
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Doctrow, S.R. and Kulakowski, E.C. Angiogenesis modulators -- new drugs for controlling blood vessel growth?. Drug News and Perspectives. 1989; 2:74-81.
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Doctrow SR, Lowenstein JM. Inhibition of phosphatidylinositol kinase in vascular smooth muscle membranes by adenosine and related compounds. Biochem Pharmacol. 1987 Jul 15; 36(14):2255-62. PMID: 3038119
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Doctrow SR, Folkman J. Protein kinase C activators suppress stimulation of capillary endothelial cell growth by angiogenic endothelial mitogens. J Cell Biol. 1987 Mar; 104(3):679-87. PMID: 3469205; PMCID: PMC2114554
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Doctrow SR, Lowenstein JM. Adenosine and 5'-chloro-5'-deoxyadenosine inhibit the phosphorylation of phosphatidylinositol and myosin light chain in calf aorta smooth muscle. J Biol Chem. 1985 Mar 25; 260(6):3469-76. PMID: 3919023