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MD, Technion - Israel Institute of Technology
PhD, Technion - Israel Institute of Technology
BSc, Technion - Israel Institute of Technology

Websites

	School of Medicine Faculty
	Google Scholar
	ResearchGate

ORCID : 0000-0002-9502-2661

Research
Publications

BMC Research
NIH RePORTER Research

Role of IAPP in Islet Dysfunction in Diabetes
04/01/2015 - 01/31/2020 (PI)
Univ of California, Los Angeles NIH-NIDDK

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (PI)
NIH-NIDDK
5R01DK074778-10

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01DK074778-10

Metabolic Signal Transduction in Adipocytes 2
02/01/2014 - 01/31/2017 (PI)
NIH-NIDDK
5R01DK056690-14

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (PI)
NIH-NIDDK
1R01DK099618-01A1

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01DK099618-03

Testing Mitochondrial Bioenergetics
09/05/2012 - 03/31/2016 (PI)
BioEnergetics, LLC

Metabolic Signal Transduction in Adipocytes
04/01/2011 - 01/31/2016 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01 DK056690-13

Binding of Annexin Proteins to Cancer Cells
08/01/2013 - 10/01/2015 (PI)
Advanced Proteome Therapeutics, Inc.

Metabolic Regulation of Insulin Secretion
09/15/2010 - 12/30/2014 (Activity-level PI)
PI: Barbara E. Corkey, PhD
NIH-NIDDK
5R01 DK035914-28

Showing 10 of 20 results. Show All Results

Title

Yr	Title	Project-Sub Proj
2023	OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADINGFOR TREATING MESOTHELIOMA	5R01CA232056-05
2022	Role of the heme-related mitochondrial antioxidant ABCB10 in alcoholic liver disease	5R01AA026914-04
2022	OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADINGFOR TREATING MESOTHELIOMA	5R01CA232056-04
2021	MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES	3R41ES031043-01A1S1
2021	OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA	5R01CA232056-03
2020	MITOCHONDRIAL RESPIROMETRY IN FROZEN BIOLOGICAL SAMPLES	1R41ES031043-01A1
2020	A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles	5R21AG060456-02
2020	R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD	5R21AG063373-02
2020	OPTIMIZATION OF NANOPARTICLE TUMOR-LOCALIZATION AND DRUG-LOADING FOR TREATING MESOTHELIOMA	5R01CA232056-02
2019	A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles	1R21AG060456-01A1

Showing 10 of 52 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Desai M, Stiles L, Torsoni AS, Torsoni MA, Shirihai OS, Ross MG. TNFa-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice. Brain Sci. 2022 Jul 09; 12(7). PMID: 35884707; PMCID: PMC9316209; DOI: 10.3390/brainsci12070900;

Petcherski A, Sharma M, Daskou M, Satta S, Vasilopoulos H, Hugo C, Ritou E, Dillon BJ, Fung E, Garcia G, Scafoglio C, Purkayastha A, Gomperts BN, Fishbein GA, Arumugaswami V, Liesa M, Shirihai OS, Kelesidis T. Mitoquinone mesylate targets SARS-CoV-2 and associated lung inflammation through host pathways. bioRxiv. 2022 Feb 24. PMID: 35233569; PMCID: PMC8887067; DOI: 10.1101/2022.02.22.481100;

Kelesidis T, Madhav S, Petcherski A, Cristelle H, O'Connor E, Hultgren NW, Ritou E, Williams DS, Shirihai OS, Reddy ST. The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells. Virulence. 2021 12; 12(1):2214-2227. PMID: 34494942; PMCID: PMC8437485; DOI: 10.1080/21505594.2021.1964329;

Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M. Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance. Mol Metab. 2022 01; 55:101403.View Related Profiles.

Wolf, Dane
Nocito, Laura
Shirihai, Orian

PMID: 34823065; PMCID: PMC8689243; DOI: 10.1016/j.molmet.2021.101403;

Shen N, Korm S, Karantanos T, Li D, Zhang X, Ritou E, Xu H, Lam A, English J, Zong WX, Liu CT, Shirihai O, Feng H. DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer. Commun Biol. 2021 11 16; 4(1):1289.View Related Profiles.

Liu, Ching-Ti
Feng, Hui
Shen, Ning
Shirihai, Orian
Korm, Sovannarith

PMID: 34785772; PMCID: PMC8595664; DOI: 10.1038/s42003-021-02805-8;

Brownstein AJ, Veliova M, Acin-Perez R, Liesa M, Shirihai OS. ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity. Rev Endocr Metab Disord. 2022 02; 23(1):121-131. PMID: 34741717; PMCID: PMC8873062; DOI: 10.1007/s11154-021-09690-w;

Ngo J, Osto C, Villalobos F, Shirihai OS. Mitochondrial Heterogeneity in Metabolic Diseases. Biology (Basel). 2021 Sep 17; 10(9). PMID: 34571805; PMCID: PMC8470264; DOI: 10.3390/biology10090927;

Acin-Perez R, Benincá C, Shabane B, Shirihai OS, Stiles L. Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives. Life (Basel). 2021 Sep 10; 11(9). PMID: 34575097; PMCID: PMC8467772; DOI: 10.3390/life11090949;

Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Rep. 2021 08 31; 36(9):109636.View Related Profiles.

Emili, Andrew
Tilston-Lunel, Andrew
Blum, Benjamin
Kotton, Darrell
Shirihai, Orian
Varelas, Xaralabos

PMID: 34469722; PMCID: PMC8432578; DOI: 10.1016/j.celrep.2021.109636;

Acín-Perez R, Petcherski A, Veliova M, Benador IY, Assali EA, Colleluori G, Cinti S, Brownstein AJ, Baghdasarian S, Livhits MJ, Yeh MW, Krishnan KC, Vergnes L, Winn NC, Padilla J, Liesa M, Sacks HS, Shirihai OS. Recruitment and remodeling of peridroplet mitochondria in human adipose tissue. Redox Biol. 2021 10; 46:102087.View Related Profiles.

Benador, Ilan
Shirihai, Orian

PMID: 34411987; PMCID: PMC8377484; DOI: 10.1016/j.redox.2021.102087;

Showing 10 of 159 results. Show More

Rai P, Janardhan KS, Meacham J, Madenspacher JH, Lin WC, Karmaus PWF, Martinez J, Li QZ, Yan M, Zeng J, Grinstaff MW, Shirihai OS, Taylor GA, Fessler MB. IRGM1 links mitochondrial quality control to autoimmunity. Nat Immunol. 2021 03; 22(3):312-321.View Related Profiles.

Grinstaff, Mark
Shirihai, Orian

PMID: 33510463; PMCID: PMC7906953; DOI: 10.1038/s41590-020-00859-0;

Miller N, Wolf D, Alsabeeh N, Mahdaviani K, Segawa M, Liesa M, Shirihai OS. High-Throughput Image Analysis of Lipid-Droplet-Bound Mitochondria. Methods Mol Biol. 2021; 2276:285-303.View Related Profiles.

Mahdaviani, Kiana
Alsabeeh, Nour
Shirihai, Orian

PMID: 34060050

Ngo J, Benador IY, Brownstein AJ, Vergnes L, Veliova M, Shum M, Acín-Pérez R, Reue K, Shirihai OS, Liesa M. Isolation and functional analysis of peridroplet mitochondria from murine brown adipose tissue. STAR Protoc. 2021 Mar 19; 2(1):100243.View Related Profiles.

Benador, Ilan
Shirihai, Orian

PMID: 33458705; PMCID: PMC7797917; DOI: 10.1016/j.xpro.2020.100243;

Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein AJ, Desousa BR, Acín-Pérez R, Petcherski A, Assali EA, Stiles L, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, Shirihai OS. Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling. EMBO Rep. 2020 12 03; 21(12):e49634.View Related Profiles.

Corkey, Barbara
Benador, Ilan
Mahdaviani, Kiana
Shirihai, Orian

PMID: 33275313; PMCID: PMC7726774; DOI: 10.15252/embr.201949634;

Zeng J, Shirihai OS, Grinstaff MW. Modulating lysosomal pH: a molecular and nanoscale materials design perspective. J Life Sci (Westlake Village). 2020 Dec; 2(4):25-37.View Related Profiles.

Grinstaff, Mark
Shirihai, Orian

PMID: 33403369; PMCID: PMC7781074; DOI: 10.36069/jols/20201204;

Osto C, Benador IY, Ngo J, Liesa M, Stiles L, Acin-Perez R, Shirihai OS. Measuring Mitochondrial Respiration in Previously Frozen Biological Samples. Curr Protoc Cell Biol. 2020 12; 89(1):e116.View Related Profiles.

Benador, Ilan
Shirihai, Orian

PMID: 33320426

Shum M, Ngo J, Shirihai OS, Liesa M. Mitochondrial oxidative function in NAFLD: Friend or foe? Mol Metab. 2021 08; 50:101134. PMID: 33276146; PMCID: PMC8324685; DOI: 10.1016/j.molmet.2020.101134;

Gonzalez-Ibanez AM, Ruiz LM, Jensen E, Echeverria CA, Romero V, Stiles L, Shirihai OS, Elorza AA. Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics. Front Cell Dev Biol. 2020; 8:592035. PMID: 33330472; PMCID: PMC7719720; DOI: 10.3389/fcell.2020.592035;

Jones AE, Sheng L, Acevedo A, Veliova M, Shirihai OS, Stiles L, Divakaruni AS. Forces, fluxes, and fuels: tracking mitochondrial metabolism by integrating measurements of membrane potential, respiration, and metabolites. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C80-C91. PMID: 33147057; PMCID: PMC7846976; DOI: 10.1152/ajpcell.00235.2020;

Acín-Pérez R, Iborra S, Martí-Mateos Y, Cook ECL, Conde-Garrosa R, Petcherski A, Muñoz MDM, Martínez de Mena R, Krishnan KC, Jiménez C, Bolaños JP, Laakso M, Lusis AJ, Shirihai OS, Sancho D, Enríquez JA. Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity. Nat Metab. 2020 09; 2(9):974-988. PMID: 32943786; PMCID: PMC8225238; DOI: 10.1038/s42255-020-00273-8;

Yang J, Guo Y, Henning SM, Chan B, Long J, Zhong J, Acin-Perez R, Petcherski A, Shirihai O, Heber D, Li Z. Ellagic Acid and Its Microbial Metabolite Urolithin A Alleviate Diet-Induced Insulin Resistance in Mice. Mol Nutr Food Res. 2020 10; 64(19):e2000091. PMID: 32783299; PMCID: PMC9185853; DOI: 10.1002/mnfr.202000091;

Cerqueira FM, von Stockum S, Giacomello M, Goliand I, Kakimoto P, Marchesan E, De Stefani D, Kowaltowski AJ, Ziviani E, Shirihai OS. A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake. Redox Biol. 2020 10; 37:101676.View Related Profiles.

Cerqueira, Fernanda
Shirihai, Orian

PMID: 32956978; PMCID: PMC7509235; DOI: 10.1016/j.redox.2020.101676;

Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. Estrogen receptor a controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Sci Transl Med. 2020 08 05; 12(555).View Related Profiles.

Wolf, Dane
Shirihai, Orian

PMID: 32759275; PMCID: PMC8212422; DOI: 10.1126/scitranslmed.aax8096;

Assali EA, Jones AE, Veliova M, Acín-Pérez R, Taha M, Miller N, Shum M, Oliveira MF, Las G, Liesa M, Sekler I, Shirihai OS. NCLX prevents cell death during adrenergic activation of the brown adipose tissue. Nat Commun. 2020 07 03; 11(1):3347.View Related Profiles.

Las, Guy
Shirihai, Orian

PMID: 32620768; PMCID: PMC7334226; DOI: 10.1038/s41467-020-16572-3;

Momcilovic M, Shirihai O, Murphy MP, Koehler CM, Sadeghi S, Shackelford DB. Reply to: In vivo quantification of mitochondrial membrane potential. Nature. 2020 07; 583(7815):E19-E20. PMID: 32641810

Segawa M, Wolf DM, Hultgren NW, Williams DS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria. Life Sci Alliance. 2020 07; 3(7).View Related Profiles.

Wolf, Dane
Shirihai, Orian

PMID: 32499316; PMCID: PMC7283135; DOI: 10.26508/lsa.201900620;

Veliova M, Petcherski A, Liesa M, Shirihai OS. The biology of lipid droplet-bound mitochondria. Semin Cell Dev Biol. 2020 12; 108:55-64. PMID: 32446655; PMCID: PMC8019155; DOI: 10.1016/j.semcdb.2020.04.013;

Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO J. 2020 07 01; 39(13):e104073.View Related Profiles.

Benador, Ilan
Shirihai, Orian

PMID: 32432379; PMCID: PMC7327496; DOI: 10.15252/embj.2019104073;

Bradley MC, Yang K, Fernández-Del-Río L, Ngo J, Ayer A, Tsui HS, Novales NA, Stocker R, Shirihai OS, Barros MH, Clarke CF. COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10. J Biol Chem. 2020 05 01; 295(18):6023-6042. PMID: 32205446; PMCID: PMC7196636; DOI: 10.1074/jbc.RA119.012420;

Wolf DM, Segawa M, Shirihai OS, Liesa M. Method for live-cell super-resolution imaging of mitochondrial cristae and quantification of submitochondrial membrane potentials. Methods Cell Biol. 2020; 155:545-555.View Related Profiles.

Wolf, Dane
Shirihai, Orian

PMID: 32183976; PMCID: PMC7216778; DOI: 10.1016/bs.mcb.2019.12.006;

Kondadi AK, Anand R, Hänsch S, Urbach J, Zobel T, Wolf DM, Segawa M, Liesa M, Shirihai OS, Weidtkamp-Peters S, Reichert AS. Cristae undergo continuous cycles of membrane remodelling in a MICOS-dependent manner. EMBO Rep. 2020 03 04; 21(3):e49776.View Related Profiles.

Wolf, Dane
Shirihai, Orian

PMID: 32067344; PMCID: PMC7054676; DOI: 10.15252/embr.201949776;

Cerqueira FM, Kozer N, Petcherski A, Baranovski BM, Wolf D, Assali EA, Roth Y, Gazit R, Barr H, Lewis EC, Las G, Shirihai OS. MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy. Biochem J. 2020 01 31; 477(2):461-475.View Related Profiles.

Cerqueira, Fernanda
Las, Guy
Shirihai, Orian

PMID: 32003437

Las G, Oliveira MF, Shirihai OS. Emerging roles of ß-cell mitochondria in type-2-diabetes. Mol Aspects Med. 2020 02; 71:100843.View Related Profiles.

Las, Guy
Shirihai, Orian

PMID: 31918997

Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2020 01; 577(7791):E7. PMID: 31896820

Taddeo EP, Alsabeeh N, Baghdasarian S, Wikstrom JD, Ritou E, Sereda S, Erion K, Li J, Stiles L, Abdulla M, Swanson Z, Wilhelm JJ, Bellin MD, Kibbey RG, Liesa M, Shirihai OS. Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels. Diabetes. 2020 02; 69(2):131-145.View Related Profiles.

Erion, Karel
Alsabeeh, Nour
Shirihai, Orian

PMID: 31740442; PMCID: PMC6971491; DOI: 10.2337/db19-0379;

Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N. Author Correction: LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2019 Nov; 575(7783):E5. PMID: 31695192

Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019 11; 575(7782):380-384. PMID: 31666695; PMCID: PMC7328016; DOI: 10.1038/s41586-019-1715-0;

Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS. Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent. EMBO J. 2019 11 15; 38(22):e101056.View Related Profiles.

Wolf, Dane
Shirihai, Orian

PMID: 31609012; PMCID: PMC6856616; DOI: 10.15252/embj.2018101056;

Kowaltowski AJ, Menezes-Filho SL, Assali EA, Gonçalves IG, Cabral-Costa JV, Abreu P, Miller N, Nolasco P, Laurindo FRM, Bruni-Cardoso A, Shirihai OS. Mitochondrial morphology regulates organellar Ca2+ uptake and changes cellular Ca2+ homeostasis. FASEB J. 2019 12; 33(12):13176-13188. PMID: 31480917; PMCID: PMC9272750; DOI: 10.1096/fj.201901136R;

Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. Publisher Correction: IAPP toxicity activates HIF1a/PFKFB3 signaling delaying ß-cell loss at the expense of ß-cell function. Nat Commun. 2019 Jul 31; 10(1):3507. PMID: 31366929; PMCID: PMC6668385; DOI: 10.1038/s41467-019-11516-y;

Montemurro C, Nomoto H, Pei L, Parekh VS, Vongbunyong KE, Vadrevu S, Gurlo T, Butler AE, Subramaniam R, Ritou E, Shirihai OS, Satin LS, Butler PC, Tudzarova S. IAPP toxicity activates HIF1a/PFKFB3 signaling delaying ß-cell loss at the expense of ß-cell function. Nat Commun. 2019 06 18; 10(1):2679. PMID: 31213603; PMCID: PMC6581914; DOI: 10.1038/s41467-019-10444-1;

Yang J, Guo Y, Henning S, Chan B, Long J, Zhong J, Acin-Perez R, Petcherski A, Shirihai O, Heber D, Li Z. Ellagic Acid and Its Microbial Metabolite Urolithin a Alleviate Diet-induced Insulin Resistance in Mice (OR24-03-19). Curr Dev Nutr. 2019 Jun; 3(Suppl 1). PMID: 31224915

Liesa M, Van der Bliek A, Shirihai OS. To Fis or not to Fuse? This is the question! EMBO J. 2019 04 15; 38(8). PMID: 30936092; PMCID: PMC6463207; DOI: 10.15252/embj.2019101839;

Benador IY, Veliova M, Liesa M, Shirihai OS. Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization. Cell Metab. 2019 04 02; 29(4):827-835.View Related Profiles.

Benador, Ilan
Shirihai, Orian

PMID: 30905670; PMCID: PMC6476311; DOI: 10.1016/j.cmet.2019.02.011;

Winn NC, Acin-Perez R, Woodford ML, Hansen SA, Haney MM, Ayedun LA, Rector RS, Vieira-Potter VJ, Shirihai OS, Sacks HS, Kanaley JA, Padilla J. A Thermogenic-Like Brown Adipose Tissue Phenotype Is Dispensable for Enhanced Glucose Tolerance in Female Mice. Diabetes. 2019 09; 68(9):1717-1729. PMID: 30862679; PMCID: PMC6702635; DOI: 10.2337/db18-1070;

Salazar C, Elorza AA, Cofre G, Ruiz-Hincapie P, Shirihai O, Ruiz LM. The OXPHOS supercomplex assembly factor HIG2A responds to changes in energetic metabolism and cell cycle. J Cell Physiol. 2019 08; 234(10):17405-17419. PMID: 30779122

Zeng J, Shirihai OS, Grinstaff MW. Degradable Nanoparticles Restore Lysosomal pH and Autophagic Flux in Lipotoxic Pancreatic Beta Cells. Adv Healthc Mater. 2019 06; 8(12):e1801511.View Related Profiles.

Grinstaff, Mark
Shirihai, Orian

PMID: 30698920

Assali EA, Shlomo D, Zeng J, Taddeo EP, Trudeau KM, Erion KA, Colby AH, Grinstaff MW, Liesa M, Las G, Shirihai OS. Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in ß cells under lipotoxicity. FASEB J. 2019 03; 33(3):4154-4165.View Related Profiles.

Colby, Aaron
Las, Guy
Erion, Karel
Trudeau, Kyle
Grinstaff, Mark
Shirihai, Orian

PMID: 30550357; PMCID: PMC8793810; DOI: 10.1096/fj.201801292R;

Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL. The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Mol Metab. 2019 03; 21:51-67. PMID: 30591411; PMCID: PMC6407367; DOI: 10.1016/j.molmet.2018.11.012;

Taddeo EP, Stiles L, Sereda S, Ritou E, Wolf DM, Abdullah M, Swanson Z, Wilhelm J, Bellin M, McDonald P, Caradonna K, Neilson A, Liesa M, Shirihai OS. Individual islet respirometry reveals functional diversity within the islet population of mice and human donors. Mol Metab. 2018 10; 16:150-159.View Related Profiles.

Wolf, Dane
Shirihai, Orian

PMID: 30098928; PMCID: PMC6157638; DOI: 10.1016/j.molmet.2018.07.003;

Waters LR, Ahsan FM, Wolf DM, Shirihai O, Teitell MA. Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling. iScience. 2018 Jul 27; 5:99-109.View Related Profiles.

Wolf, Dane
Shirihai, Orian

PMID: 30240649; PMCID: PMC6123864; DOI: 10.1016/j.isci.2018.07.005;

Xu S, Catapang A, Braas D, Stiles L, Doh HM, Lee JT, Graeber TG, Damoiseaux R, Shirihai O, Herschman HR. A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer Metab. 2018; 6:7. PMID: 29988332; PMCID: PMC6022704; DOI: 10.1186/s40170-018-0181-8;

Liesa M, Shirihai OS. Mitochondrial adaptation in obesity is a ClpPicated business. EMBO Rep. 2018 06; 19(6). PMID: 29789387; PMCID: PMC5989752; DOI: 10.15252/embr.201846295;

Rodríguez-Nuevo A, Díaz-Ramos A, Noguera E, Díaz-Sáez F, Duran X, Muñoz JP, Romero M, Plana N, Sebastián D, Tezze C, Romanello V, Ribas F, Seco J, Planet E, Doctrow SR, González J, Borràs M, Liesa M, Palacín M, Vendrell J, Villarroya F, Sandri M, Shirihai O, Zorzano A. Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency. EMBO J. 2018 05 15; 37(10).View Related Profiles.

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Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF, Cinti S, Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE, Liesa M, Shirihai OS. Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion. Cell Metab. 2018 04 03; 27(4):869-885.e6.View Related Profiles.

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Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. Estrogen receptor a protects pancreatic ß-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. J Biol Chem. 2018 03 30; 293(13):4735-4751. PMID: 29378845; PMCID: PMC5880140; DOI: 10.1074/jbc.M117.805069;

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Tkatch T, Greotti E, Baranauskas G, Pendin D, Roy S, Nita LI, Wettmarshausen J, Prigge M, Yizhar O, Shirihai OS, Fishman D, Hershfinkel M, Fleidervish IA, Perocchi F, Pozzan T, Sekler I. Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):E5167-E5176. PMID: 28611221; PMCID: PMC5495261; DOI: 10.1073/pnas.1703623114;

Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 Jul; 18(7):1123-1138.View Related Profiles.

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Zeng C, Mulas F, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, Sander M. Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal ß Cell Proliferation. Cell Metab. 2017 May 02; 25(5):1160-1175.e11.View Related Profiles.

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Trudeau KM, Colby AH, Zeng J, Las G, Feng JH, Grinstaff MW, Shirihai OS. Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity. J Cell Biol. 2016 Jul 04; 214(1):25-34.View Related Profiles.

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Liesa M, Shirihai OS. Mitochondrial Networking in T Cell Memory. Cell. 2016 Jun 30; 166(1):9-10. PMID: 27368094; DOI: 10.1016/j.cell.2016.06.035;

Liu R, Colby AH, Gilmore D, Schulz M, Zeng J, Padera RF, Shirihai O, Grinstaff MW, Colson YL. Nanoparticle tumor localization, disruption of autophagosomal trafficking, and prolonged drug delivery improve survival in peritoneal mesothelioma. Biomaterials. 2016 Sep; 102:175-86.View Related Profiles.

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Cerqueira FM, Chausse B, Baranovski BM, Liesa M, Lewis EC, Shirihai OS, Kowaltowski AJ. Diluted serum from calorie-restricted animals promotes mitochondrial ß-cell adaptations and protect against glucolipotoxicity. FEBS J. 2016 Mar; 283(5):822-33.View Related Profiles.

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Forni MF, Peloggia J, Trudeau K, Shirihai O, Kowaltowski AJ. Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics. Stem Cells. 2016 Mar; 34(3):743-55.View Related Profiles.

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Mahdaviani K, Chess D, Wu Y, Shirihai O, Aprahamian TR. Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes. Metabolism. 2016 Jan; 65(1):26-35.View Related Profiles.

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Alves TC, Pongratz RL, Zhao X, Yarborough O, Sereda S, Shirihai O, Cline GW, Mason G, Kibbey RG. Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle. Cell Metab. 2015 Nov 3; 22(5):936-47. PMID: 26411341; PMCID: PMC4635072; DOI: 10.1016/j.cmet.2015.08.021;

Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE. Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional ß cells. J Clin Invest. 2015 Oct 1; 125(10):3847-60. PMID: 26389676; PMCID: PMC4607115; DOI: 10.1172/JCI82498;

Saha S, Ash PE, Gowda V, Liu L, Shirihai O, Wolozin B. Mutations in LRRK2 potentiate age-related impairment of autophagic flux. Mol Neurodegener. 2015; 10:26.View Related Profiles.

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Qiu W, Liesa M, Carpenter EP, Shirihai OS. ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione. PLoS One. 2015; 10(6):e0129772. PMID: 26053025; PMCID: PMC4459825; DOI: 10.1371/journal.pone.0129772;

Shirihai OS, Song M, Dorn GW. How mitochondrial dynamism orchestrates mitophagy. Circ Res. 2015 May 22; 116(11):1835-49. PMID: 25999423; PMCID: PMC4443843; DOI: 10.1161/CIRCRESAHA.116.306374;

Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R. Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2015 May; 7(5):688.View Related Profiles.

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Qiao S, Dennis M, Song X, Vadysirisack DD, Salunke D, Nash Z, Yang Z, Liesa M, Yoshioka J, Matsuzawa S, Shirihai OS, Lee RT, Reed JC, Ellisen LW. A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity. Nat Commun. 2015; 6:7014. PMID: 25916556; PMCID: PMC4421852; DOI: 10.1038/ncomms8014;

Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN. Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem Cell Reports. 2015 May 12; 4(5):873-85.View Related Profiles.

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Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Wilson S C, Edward J M. Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. J Mol Cell Cardiol. 2015 Feb; 79:275-83.View Related Profiles.

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Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS. High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II. J Mol Cell Cardiol. 2015 Jan; 78:165-73.View Related Profiles.

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PMID: 25109264; PMCID: PMC4268348; DOI: 10.1016/j.yjmcc.2014.07.018;

Las G, Shirihai OS. Miro1: new wheels for transferring mitochondria. EMBO J. 2014 May 2; 33(9):939-41.View Related Profiles.

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Hartman ML, Shirihai OS, Holbrook M, Xu G, Kocherla M, Shah A, Fetterman JL, Kluge MA, Frame AA, Hamburg NM, Vita JA. Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus. Vasc Med. 2014 Feb; 19(1):67-74.View Related Profiles.

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Wikstrom JD, Mahdaviani K, Liesa M, Sereda SB, Si Y, Las G, Twig G, Petrovic N, Zingaretti C, Graham A, Cinti S, Corkey BE, Cannon B, Nedergaard J, Shirihai OS. Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure. EMBO J. 2014 Mar 3; 33(5):418-36.View Related Profiles.

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Trudeau KM, Gottlieb RA, Shirihai OS. Measurement of mitochondrial turnover and life cycle using MitoTimer. Methods Enzymol. 2014; 547:21-38.View Related Profiles.

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Nickens KP, Wikstrom JD, Shirihai OS, Patierno SR, Ceryak S. A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity. Mitochondrion. 2013 Nov; 13(6):662-7. PMID: 24075934; PMCID: PMC3837383; DOI: 10.1016/j.mito.2013.09.005;

Ferree AW, Trudeau K, Zik E, Benador IY, Twig G, Gottlieb RA, Shirihai OS. MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age. Autophagy. 2013 Nov 1; 9(11):1887-96.View Related Profiles.

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Patel PK, Shirihai O, Huang KC. Optimal dynamics for quality control in spatially distributed mitochondrial networks. PLoS Comput Biol. 2013; 9(7):e1003108. PMID: 23874166; PMCID: PMC3708874; DOI: 10.1371/journal.pcbi.1003108;

Kalghatgi S, Spina CS, Costello JC, Liesa M, Morones-Ramirez JR, Slomovic S, Molina A, Shirihai OS, Collins JJ. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. Sci Transl Med. 2013 Jul 3; 5(192):192ra85.View Related Profiles.

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Bayeva M, Khechaduri A, Wu R, Burke MA, Wasserstrom JA, Singh N, Liesa M, Shirihai OS, Langer NB, Paw BH, Ardehali H. ATP-binding cassette B10 regulates early steps of heme synthesis. Circ Res. 2013 Jul 19; 113(3):279-87.View Related Profiles.

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Liesa M, Shirihai OS. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab. 2013 Apr 2; 17(4):491-506.View Related Profiles.

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PMID: 23562075; PMCID: PMC5967396; DOI: 10.1016/j.cmet.2013.03.002;

Picard M, Shirihai OS, Gentil BJ, Burelle Y. Mitochondrial morphology transitions and functions: implications for retrograde signaling? Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15; 304(6):R393-406. PMID: 23364527; PMCID: PMC3602821; DOI: 10.1152/ajpregu.00584.2012;

Guo W, Wong S, Li M, Liang W, Liesa M, Serra C, Jasuja R, Bartke A, Kirkland JL, Shirihai O, Bhasin S. Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in male mice. PLoS One. 2012; 7(12):e51180.View Related Profiles.

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PMID: 23240002; PMCID: PMC3519841; DOI: 10.1371/journal.pone.0051180;

Liu C, Yang Q, Hwang SJ, Sun F, Johnson AD, Shirihai OS, Vasan RS, Levy D, Schwartz F. Association of genetic variation in the mitochondrial genome with blood pressure and metabolic traits. Hypertension. 2012 Oct; 60(4):949-56.View Related Profiles.

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PMID: 22949535; PMCID: PMC3753106; DOI: 10.1161/HYPERTENSIONAHA.112.196519;

Corkey BE, Shirihai O. Metabolic master regulators: sharing information among multiple systems. Trends Endocrinol Metab. 2012 Dec; 23(12):594-601.View Related Profiles.

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Liesa M, Qiu W, Shirihai OS. Mitochondrial ABC transporters function: the role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species. Biochim Biophys Acta. 2012 Oct; 1823(10):1945-57.View Related Profiles.

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PMID: 22884976; PMCID: PMC3808996; DOI: 10.1016/j.bbamcr.2012.07.013;

Stiles L, Shirihai OS. Mitochondrial dynamics and morphology in beta-cells. Best Pract Res Clin Endocrinol Metab. 2012 Dec; 26(6):725-38. PMID: 23168275; PMCID: PMC5967392; DOI: 10.1016/j.beem.2012.05.004;

Lovy A, Molina AJ, Cerqueira FM, Trudeau K, Shirihai OS. A faster, high resolution, mtPA-GFP-based mitochondrial fusion assay acquiring kinetic data of multiple cells in parallel using confocal microscopy. J Vis Exp. 2012; (65):e3991.View Related Profiles.

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Blättler SM, Verdeguer F, Liesa M, Cunningham JT, Vogel RO, Chim H, Liu H, Romanino K, Shirihai OS, Vazquez F, Rüegg MA, Shi Y, Puigserver P. Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Mol Cell Biol. 2012 Aug; 32(16):3333-46.View Related Profiles.

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PMID: 22711985; PMCID: PMC3434543; DOI: 10.1128/MCB.00337-12;

Wikstrom JD, Sereda SB, Stiles L, Elorza A, Allister EM, Neilson A, Ferrick DA, Wheeler MB, Shirihai OS. A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. PLoS One. 2012; 7(5):e33023. PMID: 22606219; PMCID: PMC3351473; DOI: 10.1371/journal.pone.0033023;

Zhang B, Weng Z, Sismanopoulos N, Asadi S, Therianou A, Alysandratos KD, Angelidou A, Shirihai O, Theoharides TC. Mitochondria distinguish granule-stored from de novo synthesized tumor necrosis factor secretion in human mast cells. Int Arch Allergy Immunol. 2012; 159(1):23-32.View Related Profiles.

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PMID: 22966490; PMCID: PMC3404883; DOI: 10.4161/auto.19496;

Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 2012 Feb 17; 148(4):651-63.View Related Profiles.

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Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG. Role of mitofusin 2 in the renal stress response. PLoS One. 2012; 7(1):e31074.View Related Profiles.

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PMID: 22292091; PMCID: PMC3266928; DOI: 10.1371/journal.pone.0031074;

Saadeh M, Ferrante TC, Kane A, Shirihai O, Corkey BE, Deeney JT. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. PLoS One. 2012; 7(1):e30200.View Related Profiles.

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Hyde BB, Liesa M, Elorza AA, Qiu W, Haigh SE, Richey L, Mikkola HK, Schlaeger TM, Shirihai OS. The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo. Cell Death Differ. 2012 Jul; 19(7):1117-26.View Related Profiles.

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PMID: 22240895; PMCID: PMC3374075; DOI: 10.1038/cdd.2011.195;

Ferree A, Shirihai O. Mitochondrial dynamics: the intersection of form and function. Adv Exp Med Biol. 2012; 748:13-40.View Related Profiles.

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PMID: 22729853; PMCID: PMC5967395; DOI: 10.1007/978-1-4614-3573-0_2;

Gilkerson RW, De Vries RL, Lebot P, Wikstrom JD, Torgyekes E, Shirihai OS, Przedborski S, Schon EA. Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Hum Mol Genet. 2012 Mar 1; 21(5):978-90. PMID: 22080835; PMCID: PMC3277306; DOI: 10.1093/hmg/ddr529;

Robson-Doucette CA, Sultan S, Allister EM, Wikstrom JD, Koshkin V, Bhattacharjee A, Prentice KJ, Sereda SB, Shirihai OS, Wheeler MB. Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Diabetes. 2011 Nov; 60(11):2710-9. PMID: 21984579; PMCID: PMC3198081; DOI: 10.2337/db11-0132;

Las G, Serada SB, Wikstrom JD, Twig G, Shirihai OS. Fatty acids suppress autophagic turnover in ß-cells. J Biol Chem. 2011 Dec 9; 286(49):42534-44.View Related Profiles.

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PMID: 21859708; PMCID: PMC3234912; DOI: 10.1074/jbc.M111.242412;

Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16; 124(7):806-13.View Related Profiles.

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PMID: 21788586; PMCID: PMC4491919; DOI: 10.1161/CIRCULATIONAHA.110.003418;

Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE, Hamburg NM, Frame AA, Caiano TL, Kluge MA, Duess MA, Levit A, Kim B, Hartman ML, Joseph L, Shirihai OS, Vita JA. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation. 2011 Jul 26; 124(4):444-53.View Related Profiles.

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PMID: 21747057; PMCID: PMC3149100; DOI: 10.1161/CIRCULATIONAHA.110.014506;

Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song WJ, Sereda S, Clerc P, Polster BM, Aja SM, Pletnikov MV, Kensler TW, Shirihai OS, Iijima M, Hussain MA, Sesaki H. The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol Biol Cell. 2011 Jul 1; 22(13):2235-45. PMID: 21551073; PMCID: PMC3128526; DOI: 10.1091/mbc.E10-12-0933;

Twig G, Shirihai OS. The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal. 2011 May 15; 14(10):1939-51. PMID: 21128700; PMCID: PMC3078508; DOI: 10.1089/ars.2010.3779;

Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011 Apr 1; 25(7):717-29.View Related Profiles.

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PMID: 21406549; PMCID: PMC3070934; DOI: 10.1101/gad.2016111;

Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011 Feb 17; 470(7334):359-65.View Related Profiles.

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PMID: 21307849; PMCID: PMC3741661; DOI: 10.1038/nature09787;

Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature. 2010 Dec 2; 468(7324):659-63. PMID: 21124451; PMCID: PMC3037591; DOI: 10.1038/nature09572;

Las G, Shirihai OS. The role of autophagy in ß-cell lipotoxicity and type 2 diabetes. Diabetes Obes Metab. 2010 Oct; 12 Suppl 2:15-9.View Related Profiles.

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PMID: 21029295; PMCID: PMC3786363; DOI: 10.1111/j.1463-1326.2010.01268.x;

Twig G, Liu X, Liesa M, Wikstrom JD, Molina AJ, Las G, Yaniv G, Hajnóczky G, Shirihai OS. Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C477-87.View Related Profiles.

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PMID: 20445168; PMCID: PMC2928626; DOI: 10.1152/ajpcell.00427.2009;

Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 2010 Jan 22; 140(2):280-93. PMID: 20141841; PMCID: PMC2821045; DOI: 10.1016/j.cell.2009.12.041;

Hyde BB, Twig G, Shirihai OS. Organellar vs cellular control of mitochondrial dynamics. Semin Cell Dev Biol. 2010 Aug; 21(6):575-81. PMID: 20079451; PMCID: PMC3808978; DOI: 10.1016/j.semcdb.2010.01.003;

Wang T, Si Y, Shirihai OS, Si H, Schultz V, Corkey RF, Hu L, Deeney JT, Guo W, Corkey BE. Respiration in adipocytes is inhibited by reactive oxygen species. Obesity (Silver Spring). 2010 Aug; 18(8):1493-502.View Related Profiles.

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PMID: 20035277; PMCID: PMC6154476; DOI: 10.1038/oby.2009.456;

Liu S, Okada T, Assmann A, Soto J, Liew CW, Bugger H, Shirihai OS, Abel ED, Kulkarni RN. Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One. 2009; 4(11):e7983. PMID: 19956695; PMCID: PMC2776992; DOI: 10.1371/journal.pone.0007983;

Tagen M, Elorza A, Kempuraj D, Boucher W, Kepley CL, Shirihai OS, Theoharides TC. Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. J Immunol. 2009 Nov 15; 183(10):6313-9. PMID: 19846869; PMCID: PMC2925218; DOI: 10.4049/jimmunol.0803422;

Liu X, Weaver D, Shirihai O, Hajnóczky G. Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics. EMBO J. 2009 Oct 21; 28(20):3074-89. PMID: 19745815; PMCID: PMC2771091; DOI: 10.1038/emboj.2009.255;

Chen W, Paradkar PN, Li L, Pierce EL, Langer NB, Takahashi-Makise N, Hyde BB, Shirihai OS, Ward DM, Kaplan J, Paw BH. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16263-8. PMID: 19805291; PMCID: PMC2752562; DOI: 10.1073/pnas.0904519106;

Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE. The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets. Obesity (Silver Spring). 2009 Oct; 17(10):1856-60.View Related Profiles.

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PMID: 19644453; PMCID: PMC3808997; DOI: 10.1038/oby.2009.234;

Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS. Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009 Oct; 58(10):2303-15.View Related Profiles.

Molina, Anthony J.A.
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PMID: 19581419; PMCID: PMC2750232; DOI: 10.2337/db07-1781;

Wikstrom JD, Twig G, Shirihai OS. What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy? Int J Biochem Cell Biol. 2009 Oct; 41(10):1914-27. PMID: 19549572; DOI: 10.1016/j.biocel.2009.06.006;

Mouli PK, Twig G, Shirihai OS. Frequency and selectivity of mitochondrial fusion are key to its quality maintenance function. Biophys J. 2009 May 6; 96(9):3509-18. PMID: 19413957; PMCID: PMC2711405; DOI: 10.1016/j.bpj.2008.12.3959;

Molina AJ, Shirihai OS. Monitoring mitochondrial dynamics with photoactivatable [corrected] green fluorescent protein. Methods Enzymol. 2009; 457:289-304.View Related Profiles.

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PMID: 19426874; PMCID: PMC5967387; DOI: 10.1016/S0076-6879(09)05016-2;

Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS. UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008 Nov 7; 283(45):30461-70. PMID: 18687678; PMCID: PMC2576537; DOI: 10.1074/jbc.M805400200;

Twig G, Hyde B, Shirihai OS. Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta. 2008 Sep; 1777(9):1092-7. PMID: 18519024; PMCID: PMC3809017; DOI: 10.1016/j.bbabio.2008.05.001;

Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53.View Related Profiles.

Corkey, Barbara
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PMID: 18223655; PMCID: PMC3918232; DOI: 10.1038/nm1717;

Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 23; 27(2):433-46.View Related Profiles.

Corkey, Barbara
Las, Guy
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PMID: 18200046; PMCID: PMC2234339; DOI: 10.1038/sj.emboj.7601963;

Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS. beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 2007 Oct; 56(10):2569-78.View Related Profiles.

Corkey, Barbara
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PMID: 17686943

Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE. Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 2007 Apr 1; 403(1):197-205.View Related Profiles.

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Deeney, Jude
Tornheim, Keith
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PMID: 17181533; PMCID: PMC1828901; DOI: 10.1042/BJ20061209;

Sheftel AD, Zhang AS, Brown C, Shirihai OS, Ponka P. Direct interorganellar transfer of iron from endosome to mitochondrion. Blood. 2007 Jul 1; 110(1):125-32. PMID: 17376890

Haigh SE, Twig G, Molina AA, Wikstrom JD, Deutsch M, Shirihai OS. PA-GFP: a window into the subcellular adventures of the individual mitochondrion. Novartis Found Symp. 2007; 287:21-36; discussion 36-46.View Related Profiles.

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Deutsch M, Deutsch A, Shirihai O, Hurevich I, Afrimzon E, Shafran Y, Zurgil N. A novel miniature cell retainer for correlative high-content analysis of individual untethered non-adherent cells. Lab Chip. 2006 Aug; 6(8):995-1000. PMID: 16874368

Twig G, Graf SA, Wikstrom JD, Mohamed H, Haigh SE, Elorza A, Deutsch M, Zurgil N, Reynolds N, Shirihai OS. Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP. Am J Physiol Cell Physiol. 2006 Jul; 291(1):C176-84.View Related Profiles.

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PMID: 16481372

Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE. Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells. Am J Physiol Endocrinol Metab. 2006 Jan; 290(1):E143-E148.View Related Profiles.

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PMID: 16144817

Twig G, Graf SA, Messerli MA, Smith PJ, Yoo SH, Shirihai OS. Synergistic amplification of beta-amyloid- and interferon-gamma-induced microglial neurotoxic response by the senile plaque component chromogranin A. Am J Physiol Cell Physiol. 2005 Jan; 288(1):C169-75. PMID: 15342341

Katzman SM, Messerli MA, Barry DT, Grossman A, Harel T, Wikstrom JD, Corkey BE, Smith PJ, Shirihai OS. Mitochondrial metabolism reveals a functional architecture in intact islets of Langerhans from normal and diabetic Psammomys obesus. Am J Physiol Endocrinol Metab. 2004 Dec; 287(6):E1090-9.View Related Profiles.

Corkey, Barbara
Shirihai, Orian

PMID: 15339741

Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H, Gutt B, Landgraf R, Garrow AP, Vileikyte L, Findlow A, Waterman C, Boulton AJ, Shankhdhar K, Shankhdhar L, Shankhdhar U, Petrova NL, Foster AV, Edmonds ME, Ferraresi R, Caravaggi C, De Giglio R, Cavaiani P, Pogliaghi I, Sommariva E, Katz IA, Harlan A, Miranda-Palma B, Prieto-Sanchez L, Armstrong DG, Bowker JH, Mizel MS, Cernea S, Wohlgelernter J, Kidron M, Modi P, Raz I, Arbit E, Nosek L, Kapitza C, Beckett P, Gelfand R, Goldberg M, Heise T, Testa MA, Turner RR, Hayes JF, Scranton RE, Simonson DC, Yang YW, Hsu YJ, Naujok O, Francini F, Jörns A, Tiedge M, Lenzen S, Abdel-Wahab YH, Marenah L, Orr DF, Shaw C, Flatt PR, Chokkalingam K, Mansell PI, Clausen P, Ekbom P, Damm P, Feldt-Rasmussen U, Nielsen B, Mathiesen ER, Feldt-Rasmussen B, Dewan S, Da Silva N, Ternan PM, Leong KS, Wilding JP, Asatiani N, Kurashvili R, Dundua M, Shelestova E, Pagava K, Ramazashvili M, Hod M, Smirnov S, Petersen JL, Justesen TI, Ringholm Nielsen L, Müller C, Højlund K, Wensaas A, Kase ET, Aas V, Rustan AC, Thoresen GH, Levin K, Beck-Nielsen H, Gaster M, Im SS, Kang SY, Kim SY, Ahn YH, Lihn AS, Schmoll D, Werner T, Kienitz A, Meyer M, Barthel A, Ailett F, Sutherland C, Walther R, Grempler R, Sasson S, Reich R, Tenenbaum T, Alpert E, Anfossi G, Russo I, Traversa M, Massucco P, Mattiello L, Doronzo G, Trovati M, Lally S, Tan CY, Owens D, Tomkin GH, Porchay I, Péan F, Bellili N, Betoulle D, Balkau B, Tichet J, Marre M, Fumeron F, Chatellier G, Alhenc-Gelas F, Nichols GA, Brown JB, Hayes RP, Bowman L, Drexel H, Saely CH, Marte T, Benzer W, Langer P, Hoefle G, Moll W, Aczel S, Karagiannis E, Lübben G, Urquhart R, Edwards G, Bruce S, Howlett HS, Cugnardey N, Turner KC, Park JS, Fiedorek FT, Avogaro A, Gallo A, Pinton P, Rizzuto R, Murphy E, Ceolotto G, Caterson I, Guy-Grand B, Hill J, Barone M, Aiello A, Allochis G, Borzì V, Cannatà F, Caronna S, D'Avanzo A, Elli R, Formoso G, Paroli A, Scardapane R, Sorichetti P, Tatti P, Viviani G, Santeusanio F, Manzella D, Grella R, Abbatecola AM, Paolisso G, Søndergaard LG, Monster TB, Johnsen SP, Olsen ML, McLaughlin JK, Sørensen HT, Lervang HH, Rungby J, Lyssenko V, Fredriksson J, Almgren P, Anevski D, Orho-Melander M, Sjögren M, Tuomi T, Groop L, Jaziri R, Aubert R, Tuomilehto J, Hu G, Jousilahti P, Peltonen M, Lindstrom J, Laina A, Alevizaki M, Philippou G, Souvatzoglou A, Anastasiou E, Alba S, Metcalf BS, Voss LD, Jeffery AN, Wilkin TJ, Glüimer C, Colagiuri S, Vistisen D, Borch-Johnsen K, Haynes A, Bower C, Bulsara MK, Jones TW, Davis EA, Mortensen HB, Hougaard P, Holl R, Swift P, Pociot F, Knip M, Hansen L, Szadkowska A, Pietrzak I, Zmyslowska A, Wyka K, Bodalski J, Holl RW, Swift R, Hougaard R, Gerstl EM, Engelsberger I, Rabl W, Rosenbauer J, Gröbe H, Hofer SE, Krause U, Dabelea D, Morgan T, Pettitt DJ, Dolan L, Mayer-Davis EJ, Pihoker C, Hillier TA, Imperatore G, Ruggiero A, Hamman RE, Stylianou A, Tentolouris N, Perrea D, Tselepis AD, Lourida E, Kitsou E, Katsilambros N, Vedovato M, Dodesini AR, Lepore G, Tiengo A, Trevisan R, Penno G, Miccoli R, Pucci L, Lucchesi D, Bandinelli S, Fotino C, Triscornia S, Baldassari E, Del Prato S, Reboldi P, Santeusanio E, Fuller J, Langham RG, Gow RM, Zhang Y, Kelly DJ, Christensen PK, Parving HH, Gilbert RE, Chibalin AV, Zhong Z, Kotova O, Davidescu A, Ehrén I, Ekberg K, Wahren J, Wassef L, Buckley AJ, Rooney KB, Briody J, Thompson M, Ozanne SE, Thompson CH, Chamson-Reig A, Summers K, Arany EJ, Hill DJ, Solerte SB, Gazzaruso C, Locatelli E, Precerutti S, Schifino N, Ferrari E, Fioravanti M, Phenekos CV, Ginis A, Fragaki I, Chalkiadaki M, Tzioras C, Powell LA, McGuire GM, Jewhurst V, Trimble ER, Rasmussen BM, Vessby B, Uusitupa M, Berglund L, Pedersen E, Riccardi G, Rivellese AA, Tapsell L, Hermansen K, da Silva Xavier G, Rutter J, Rutter GA, Briaud IM, Lingohr MK, Dickson LM, McCuaig JR, Lawrence JC, Rhodes CJ, Wikstrom JD, Katzman SM, Shirihai OS, Yang J, Deng S, Wang X, Hessner MJ, Wu J, Wong RK, et al. 40th EASD View Related Profiles.

Sorensen, Henrik
Ruderman, Neil
Shirihai, Orian
Sivakumaran, Sudhir

PMID: 27770180; PMCID: PMC7096100; DOI: 10.1007/BF03375463;

Graf SA, Haigh SE, Corson ED, Shirihai OS. Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). J Biol Chem. 2004 Oct 8; 279(41):42954-63.View Related Profiles.

Shirihai, Orian
Haigh Molina, Sarah

PMID: 15215243

Best JL, Ganiatsas S, Agarwal S, Changou A, Salomoni P, Shirihai O, Meluh PB, Pandolfi PP, Zon LI. SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell. 2002 Oct; 10(4):843-55. PMID: 12419228

Twig G, Jung SK, Messerli MA, Smith PJ, Shirihai OS. Real-time detection of reactive oxygen intermediates from single microglial cells. Biol Bull. 2001 Oct; 201(2):261-2. PMID: 11687412

Shirihai OS, Gregory T, Yu C, Orkin SH, Weiss MJ. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J. 2000 Jun 1; 19(11):2492-502. PMID: 10835348; PMCID: PMC212759

Sobko A, Peretz A, Shirihai O, Etkin S, Cherepanova V, Dagan D, Attali B. Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation. J Neurosci. 1998 Dec 15; 18(24):10398-408. PMID: 9852577

Shirihai O, Attali B, Dagan D, Merchav S. Expression of two inward rectifier potassium channels is essential for differentiation of primitive human hematopoietic progenitor cells. J Cell Physiol. 1998 Nov; 177(2):197-205. PMID: 9766516

Shirihai O, Smith P, Hammar K, Dagan D. Microglia generate external proton and potassium ion gradients utilizing a member of the H/K ATPase family. Glia. 1998 Aug; 23(4):339-48. PMID: 9671964

Shirihai O, Merchav S, Attali B, Dagan D. K+ channel antisense oligodeoxynucleotides inhibit cytokine-induced expansion of human hemopoietic progenitors. Pflugers Arch. 1996 Feb; 431(4):632-8. PMID: 8596709

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