Orian S. Shirihai, MD, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Medicine
Gastroenterology Section

MD, Technion-israel Institute of Technology
PhD, Technion-israel Institute of Technology



Expertise includes: Mitochondial biology; Mitochondrial bioenergetics; Mitochondrial dynamics; Imaging of mitochondrial architecture and function; Microscopy.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Boston Medical Center





Role of IAPP in Islet Dysfunction in Diabetes
04/01/2015 - 01/31/2020 (PI)
Univ of California, Los Angeles NIH-NIDDK

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (PI)
NIH-NIDDK
5R01DK074778-10

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (Activity-level PI)
PI: Barbara A. Corkey, PhD
NIH-NIDDK
5R01DK074778-10

Metabolic Signal Transduction in Adipocytes 2
02/01/2014 - 01/31/2017 (PI)
NIH-NIDDK
5R01DK056690-14

Mitochondrial regulation of energy efficiency
04/01/2014 - 03/31/2016 (PI)
NIH-NIDDK
1R01DK099618-01A1

Mitochondrial regulation of energy efficiency
04/01/2014 - 03/31/2016 (Activity-level PI)
PI: Barbara A. Corkey, PhD
NIH-NIDDK
1R01DK099618-01A1

Testing Mitochondrial Bioenergetics
09/05/2012 - 03/31/2016 (PI)
BioEnergetics, LLC

Metabolic Signal Transduction in Adipocytes
04/01/2011 - 01/31/2016 (Activity-level PI)
PI: Barbara A. Corkey, PhD
NIH-NIDDK
5R01 DK056690-13

Binding of Annexin Proteins to Cancer Cells
08/01/2013 - 10/01/2015 (PI)
Advanced Proteome Therapeutics, Inc.

Metabolic Regulation of Insulin Secretion
09/15/2010 - 12/30/2014 (Activity-level PI)
PI: Barbara A. Corkey, PhD
NIH-NIDDK
5R01 DK035914-28

Showing 10 of 20 results. Show All Results


Yr Title Project-Sub Proj Pubs
2017 Mitochondrial regulation of energy efficiency 7R01DK099618-04 1
2016 Mitochondrial regulation of energy efficiency 5R01DK099618-03 1
2015 Mitochondrial regulation of energy efficiency 5R01DK099618-02 1
2015 Mitochondrial dynamics in beta cell function and dysfunction 5R01DK074778-10 38
2015 Metabolic Signal Transduction in Adipocytes 5R01DK056690-15 38
2014 Mitochondrial regulation of energy efficiency 1R01DK099618-01A1 1
2014 Mitochondrial dynamics in beta cell function and dysfunction 5R01DK074778-09 38
2014 Metabolic Signal Transduction in Adipocytes 5R01DK056690-14 38
2013 Mitochondrial dynamics in beta cell function and dysfunction 5R01DK074778-08 38
2013 Metabolic Signal Transduction in Adipocytes 5R01DK056690-13 38
Showing 10 of 40 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Lim JA, Li L, Shirihai OS, Trudeau KM, Puertollano R, Raben N. Modulation of mTOR signaling as a strategy for the treatment of Pompe disease. EMBO Mol Med. 2017 Mar; 9(3):353-370.View Related Profiles. PMID: 28130275; DOI: 10.15252/emmm.201606547;.
  2. Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016 11 17; 539(7629):390-395. PMID: 27799657; DOI: 10.1038/nature20132;.
  3. Nolin AC, Mulhern RM, Panchenko MV, Pisarek-Horowitz A, Wang Z, Shirihai O, Borkan SC, Havasi A. Proteinuria causes dysfunctional autophagy in the proximal tubule. Am J Physiol Renal Physiol. 2016 Dec 01; 311(6):F1271-F1279.View Related Profiles. PMID: 27582098; DOI: 10.1152/ajprenal.00125.2016;.
  4. Trudeau KM, Colby AH, Zeng J, Las G, Feng JH, Grinstaff MW, Shirihai OS. Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity. J Cell Biol. 2016 Jul 04; 214(1):25-34.View Related Profiles. PMID: 27377248; PMCID: PMC4932370; DOI: 10.1083/jcb.201511042;.
  5. Liesa M, Shirihai OS. Mitochondrial Networking in T Cell Memory. Cell. 2016 Jun 30; 166(1):9-10. PMID: 27368094; DOI: 10.1016/j.cell.2016.06.035;.
  6. Liu R, Colby AH, Gilmore D, Schulz M, Zeng J, Padera RF, Shirihai O, Grinstaff MW, Colson YL. Nanoparticle tumor localization, disruption of autophagosomal trafficking, and prolonged drug delivery improve survival in peritoneal mesothelioma. Biomaterials. 2016 Sep; 102:175-86.View Related Profiles. PMID: 27343465; PMCID: PMC4948582; DOI: 10.1016/j.biomaterials.2016.06.031;.
  7. Las G, Shirihai O. Cellular Star Trek: A laser-based shuttle transfers mitochondria into cells. Mol Metab. 2016 Oct; 5(10):805-6.View Related Profiles. PMID: 27688994; DOI: 10.1016/j.molmet.2016.06.001;.
  8. Deeney JT, Belkina AC, Shirihai OS, Corkey BE, Denis GV. BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic ß-Cell. PLoS One. 2016; 11(3):e0151329.View Related Profiles. PMID: 27008626; PMCID: PMC4805167; DOI: 10.1371/journal.pone.0151329;.
  9. Cerqueira FM, Chausse B, Baranovski BM, Liesa M, Lewis EC, Shirihai OS, Kowaltowski AJ. Diluted serum from calorie-restricted animals promotes mitochondrial ß-cell adaptations and protect against glucolipotoxicity. FEBS J. 2016 Mar; 283(5):822-33.View Related Profiles. PMID: 26732506; DOI: 10.1111/febs.13632;.
  10. Fetterman JL, Holbrook M, Flint N, Feng B, Bret?n-Romero R, Linder EA, Berk BD, Duess MA, Farb MG, Gokce N, Shirihai OS, Hamburg NM, Vita JA. Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling. Atherosclerosis. 2016 Apr; 247:207-17.View Related Profiles. PMID: 26926601; PMCID: PMC4913892; DOI: 10.1016/j.atherosclerosis.2016.01.043;.
Showing 10 of 97 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 97 publications over 19 distinct years, with a maximum of 15 publications in 2012

YearPublications
19961
19983
20001
20011
20021
20044
20051
20062
20074
20084
200910
20105
20119
201215
20137
20147
201510
201611
20171
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

autopagy
fission
fusion
Mitochondria
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650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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