Orian S. Shirihai, MD, PhD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Medicine
Gastroenterology

MD, Technion - Israel Institute of Technology
PhD, Technion - Israel Institute of Technology



Expertise includes: Mitochondial biology; Mitochondrial bioenergetics; Mitochondrial dynamics; Imaging of mitochondrial architecture and function; Microscopy.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Boston Medical Center





Role of IAPP in Islet Dysfunction in Diabetes
04/01/2015 - 01/31/2020 (PI)
Univ of California, Los Angeles NIH-NIDDK

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (PI)
NIH-NIDDK

Mitochondrial Dynamics in Beta Cell Function & Dysfunction
08/01/2012 - 07/31/2017 (Activity-level PI)
PI: Barbara A. Corkey, PhD
NIH-NIDDK

Metabolic Signal Transduction in Adipocytes 2
02/01/2014 - 01/31/2017 (PI)
NIH-NIDDK

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (PI)
NIH-NIDDK

Mitochondrial regulation of energy efficiency
04/01/2014 - 04/02/2016 (Activity-level PI)
PI: Barbara A. Corkey, PhD
NIH-NIDDK

Testing Mitochondrial Bioenergetics
09/05/2012 - 03/31/2016 (PI)
BioEnergetics, LLC

Metabolic Signal Transduction in Adipocytes
04/01/2011 - 01/31/2016 (Activity-level PI)
PI: Barbara A. Corkey, PhD
NIH-NIDDK

Binding of Annexin Proteins to Cancer Cells
08/01/2013 - 10/01/2015 (PI)
Advanced Proteome Therapeutics, Inc.

Metabolic Regulation of Insulin Secretion
09/15/2010 - 12/30/2014 (Activity-level PI)
PI: Barbara A. Corkey, PhD
NIH-NIDDK

Showing 10 of 20 results. Show All Results


Yr Title Project-Sub Proj Pubs
2017 Mitochondrial regulation of energy efficiency 7R01DK099618-04 1
2016 Mitochondrial regulation of energy efficiency 5R01DK099618-03 1
2015 Mitochondrial regulation of energy efficiency 5R01DK099618-02 1
2015 Mitochondrial dynamics in beta cell function and dysfunction 5R01DK074778-10 38
2015 Metabolic Signal Transduction in Adipocytes 5R01DK056690-15 38
2014 Mitochondrial regulation of energy efficiency 1R01DK099618-01A1 1
2014 Mitochondrial dynamics in beta cell function and dysfunction 5R01DK074778-09 38
2014 Metabolic Signal Transduction in Adipocytes 5R01DK056690-14 38
2013 Mitochondrial dynamics in beta cell function and dysfunction 5R01DK074778-08 38
2013 Metabolic Signal Transduction in Adipocytes 5R01DK056690-13 38
Showing 10 of 40 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Montemurro C, Vadrevu S, Gurlo T, Butler AE, Vongbunyong KE, Petcherski A, Shirihai OS, Satin LS, Braas D, Butler PC, Tudzarova S. Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line. Cell Cycle. 2017 Aug 18; 1-14. PMID: 28820316.
  2. Tkatch T, Greotti E, Baranauskas G, Pendin D, Roy S, Nita LI, Wettmarshausen J, Prigge M, Yizhar O, Shirihai OS, Fishman D, Hershfinkel M, Fleidervish IA, Perocchi F, Pozzan T, Sekler I. Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins. Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26):E5167-E5176. PMID: 28611221.
  3. Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 Jul; 18(7):1123-1138.View Related Profiles. PMID: 28539390.
  4. Zeng C, Mulas F, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, Sander M. Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal ß Cell Proliferation. Cell Metab. 2017 May 02; 25(5):1160-1175.e11. PMID: 28467932.
  5. Lim JA, Li L, Shirihai OS, Trudeau KM, Puertollano R, Raben N. Modulation of mTOR signaling as a strategy for the treatment of Pompe disease. EMBO Mol Med. 2017 Mar; 9(3):353-370.View Related Profiles. PMID: 28130275; DOI: 10.15252/emmm.201606547;.
  6. Kottakis F, Nicolay BN, Roumane A, Karnik R, Gu H, Nagle JM, Boukhali M, Hayward MC, Li YY, Chen T, Liesa M, Hammerman PS, Wong KK, Hayes DN, Shirihai OS, Dyson NJ, Haas W, Meissner A, Bardeesy N. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016 11 17; 539(7629):390-395. PMID: 27799657; DOI: 10.1038/nature20132;.
  7. Trudeau KM, Colby AH, Zeng J, Las G, Feng JH, Grinstaff MW, Shirihai OS. Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity. J Cell Biol. 2016 Jul 04; 214(1):25-34.View Related Profiles. PMID: 27377248; PMCID: PMC4932370; DOI: 10.1083/jcb.201511042;.
  8. Liesa M, Shirihai OS. Mitochondrial Networking in T Cell Memory. Cell. 2016 Jun 30; 166(1):9-10. PMID: 27368094; DOI: 10.1016/j.cell.2016.06.035;.
  9. Liu R, Colby AH, Gilmore D, Schulz M, Zeng J, Padera RF, Shirihai O, Grinstaff MW, Colson YL. Nanoparticle tumor localization, disruption of autophagosomal trafficking, and prolonged drug delivery improve survival in peritoneal mesothelioma. Biomaterials. 2016 Sep; 102:175-86.View Related Profiles. PMID: 27343465; PMCID: PMC4948582; DOI: 10.1016/j.biomaterials.2016.06.031;.
  10. Las G, Shirihai O. Cellular Star Trek: A laser-based shuttle transfers mitochondria into cells. Mol Metab. 2016 Oct; 5(10):805-6.View Related Profiles. PMID: 27688994; DOI: 10.1016/j.molmet.2016.06.001;.
Showing 10 of 98 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 98 publications over 19 distinct years, with a maximum of 15 publications in 2012

YearPublications
19961
19983
20001
20011
20021
20044
20051
20062
20074
20084
200910
20105
20119
201215
20135
20147
201510
201610
20175
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

autopagy
fission
fusion
Mitochondria
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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