Wilson S. Colucci, MD
Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine Section

MD, Boston University



Research program studies the basic molecular and cellular mechanisms of myocardial remodeling, and the pathophysiology and treatment of heart failure.

Section Chief of Medicine in Cardiovascular Medicine
Boston University School of Medicine
Medicine
Cardiovascular Medicine Section

Research Professor
Boston University School of Medicine
Physiology & Biophysics


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Active Staff Privileges
Boston Medical Center
Medicine
Cardiology Section



RED-HF
11/01/2008 - 10/31/2013 (PI)
Amgen, Inc.

EMPHASIS-HF
12/15/2008 - 12/15/2011 (PI)
Pfizer, Inc.

ASCEND-HF
01/21/2008 - 12/15/2011 (PI)
Scios Inc

The Balance Study:Treatment of Hyponatremia Based on Lixivaptan in Nyha Class III/IV Cardiac Patient Evaluation
06/01/2008 - 06/30/2010 (PI)
Cardiokine Biopharma

HMG CoA Reductase Inhibition and Inflammation, Oxidative Stress and Vascular Stiffness in Heart Failure
07/01/2005 - 06/30/2006 (Co-PI)
Heart Failure Society of America (HFSA)

Optimize HF Registry
05/01/2003 - 05/01/2005 (PI)
Outcome Sciences (GSK and Duke)

Clinical Evaluation of Acorn Cardiac Support Device Therapy in Patients with Dilated Cardiomyopathy - A Randomized Trial in the United States
02/01/2002 - 01/31/2005 (Co-PI)
Acorn Cardiovascular, Inc.

NO and O2 - In Post-Myocardial Infarction Remodeling and Failure
09/30/1998 - 08/31/2003 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL61639 05

Double-Blind, Randomized, Placebo-Controlled, Parallel Group Study Evaluating the Effects of Different Doses of LU135252 On Left Ventricle Dimensions, Function, and Left and Right Ventricle Mass, Neurohomone Levels, and Symptoms in Patients with Advanced
07/01/2000 - 06/30/2001 (PI)
Knoll Pharmaceutical Company

Regulation of Vascular Alpha-1 Adrenergic Responses
04/26/1989 - 03/31/2001 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL42539 10


Study to evaluate the efficacy and safety of LCZ696
09/15/2014 - 08/31/2021 (PI)
Novartis Pharma Corp

Oxidative Stress in Myocardial Remodeling and Failure
04/01/2017 - 03/31/2019 (PI)
NIH-NHLBI
5R01HL064750-10

Effects of ribose supplementation on cardiac remodeling, exercise capacity and mitochondrial functio
05/19/2015 - 08/18/2016 (PI)
Ribocor, Inc.

Modification of Cardiovascular Proteins by Metabolic Disease
08/15/2010 - 08/14/2015 (PI)
Trustees of Boston University NIH-NHLBI

TOPCAT - Amendment #4 Vascular Ancillary Study
02/01/2009 - 06/30/2014 (PI)
New England Res Inst AtCor Medical, Inc.

TOPCAT
09/01/2008 - 06/30/2014 (PI)
New England Res Inst NIH-NHLBI

Oxidative Stress in Myocardial Remodeling and Failure
07/01/2008 - 06/30/2014 (PI)
NIH-NHLBI
5R01 HL064750-08

Role Of Oxidative Stress
05/01/1999 - 12/31/2010 (PI)
GlaxoSmithKline

Mechanisms of Oxidant Signaling in Post-MI
12/01/2003 - 11/30/2010 (PI)
NIH-NHLBI
5 R01 HL 061639-09

ACTION-A CHF Trial Investigating Outcomes of Exercise
09/30/2002 - 07/31/2008 (PI)
NIH-NHLBI
5 U01 HL068973-06

Showing 10 of 17 results. Show All Results


Yr Title Project-Sub Proj Pubs
2017 Oxidative Stress in Myocardial Remodeling and Failure 5R01HL064750-11 16
2016 Oxidative Stress in Myocardial Remodeling and Failure 5R01HL064750-10 16
2015 Oxidative Stress in Myocardial Remodeling and Failure 2R01HL064750-09A1 16
2011 Oxidative Stress in Myocardial Remodeling and Failure 5R01HL064750-08 16
2010 Oxidative Stress in Myocardial Remodeling and Failure 5R01HL064750-07 16
2009 Oxidative Stress in Myocardial Remodeling and Failure 5R01HL064750-06 16
2008 Oxidative Stress in Myocardial Remodeling and Failure 2R01HL064750-05A1 16
2007 ACTION - A CHF Trial Investigating Outcomes of Exercise 5U01HL068973-06 23
2007 Mechanisms of Oxidant Signaling in Post-MI Remodeling 5R01HL061639-09 43
2006 ACTION - A CHF Trial Investigating Outcomes of Exercise 5U01HL068973-05 23
Showing 10 of 37 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, Cleland JG, Colucci WS, Butler J, Voors AA, Anker SD, Pitt B, Pieske B, Filippatos G, Greene SJ, Gheorghiade M. Expert consensus document: Mitochondrial function as a therapeutic target in heart failure. Nat Rev Cardiol. 2017 04; 14(4):238-250. PMID: 28004807; DOI: 10.1038/nrcardio.2016.203;.
  2. Hobai IA, Aziz K, Buys ES, Brouckaert P, Siwik DA, Colucci WS. Distinct Myocardial Mechanisms Underlie Cardiac Dysfunction in Endotoxemic Male and Female Mice. Shock. 2016 Dec; 46(6):713-722.View Related Profiles. PMID: 27405063.
  3. Xu XJ, Babo E, Qin F, Croteau D, Colucci WS. Short-term caloric restriction in db/db mice improves myocardial function and increases high molecular weight (HMW) adiponectin. IJC Metab Endocr. 2016 Dec; 13:28-34.View Related Profiles. PMID: 27942464.
  4. Gheorghiade M, Larson CJ, Shah SJ, Greene SJ, Cleland JG, Colucci WS, Dunnmon P, Epstein SE, Kim RJ, Parsey RV, Stockbridge N, Carr J, Dinh W, Krahn T, Kramer F, Wahlander K, Deckelbaum LI, Crandall D, Okada S, Senni M, Sikora S, Sabbah HN, Butler J. Developing New Treatments for Heart Failure: Focus on the Heart. Circ Heart Fail. 2016 May; 9(5). PMID: 27166246; DOI: 10.1161/CIRCHEARTFAILURE.115.002727;.
  5. Sverdlov AL, Elezaby A, Qin F, Behring JB, Luptak I, Calamaras TD, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Bachschmid MM, Colucci WS. Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease. J Am Heart Assoc. 2016 Jan 11; 5(1).View Related Profiles. PMID: 26755553; PMCID: PMC4859372; DOI: 10.1161/JAHA.115.002555;.
  6. Miller EJ, Calamaras T, Elezaby A, Sverdlov A, Qin F, Luptak I, Wang K, Sun X, Vijay A, Croteau D, Bachschmid M, Cohen RA, Walsh K, Colucci WS. Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge. J Am Heart Assoc. 2015 Dec 31; 5(1).View Related Profiles. PMID: 26722122; PMCID: PMC4859355; DOI: 10.1161/JAHA.115.002277;.
  7. Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025.View Related Profiles. PMID: 26642319; PMCID: PMC4671598; DOI: 10.1371/journal.pone.0144025;.
  8. Wang YC, Liang CS, Gopal DM, Ayalon N, Donohue C, Santhanakrishnan R, Sandhu H, Perez AJ, Downing J, Gokce N, Colucci WS, Ho JE. Preclinical Systolic and Diastolic Dysfunctions in Metabolically Healthy and Unhealthy Obese Individuals. Circ Heart Fail. 2015 Sep; 8(5):897-904.View Related Profiles. PMID: 26175540; PMCID: PMC4573845; DOI: 10.1161/CIRCHEARTFAILURE.114.002026;.
  9. Gopal DM, Santhanakrishnan R, Wang YC, Ayalon N, Donohue C, Rahban Y, Perez AJ, Downing J, Liang CS, Gokce N, Colucci WS, Ho JE. Impaired right ventricular hemodynamics indicate preclinical pulmonary hypertension in patients with metabolic syndrome. J Am Heart Assoc. 2015 Mar; 4(3):e001597.View Related Profiles. PMID: 25758604; PMCID: PMC4392440; DOI: 10.1161/JAHA.114.001597;.
  10. Calamaras TD, Lee C, Lan F, Ido Y, Siwik DA, Colucci WS. The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling. Free Radic Biol Med. 2015 May; 82:137-46.View Related Profiles. PMID: 25617592; PMCID: PMC4387097; DOI: 10.1016/j.freeradbiomed.2015.01.007;.
Showing 10 of 311 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 310 publications over 37 distinct years, with a maximum of 21 publications in 2000 and 2001

YearPublications
19804
19819
19823
19832
19848
19859
198610
19875
19888
198911
19907
19917
19923
19936
19945
199512
199615
199710
199810
19997
200021
200121
200213
20039
200416
200514
20068
20077
20085
20096
20106
20115
20125
20135
20147
20156
20165
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Heart failure
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Boston MA 02118
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