Keywords
Last Name

Aaron Sverdlov, MD, PhD

TitlePostdoctoral Associate
InstitutionBoston University School of Medicine
DepartmentCardiovascular Institute (Whitaker)
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-8760
ORCID ORCID Icon0000-0003-2539-8038
 Awards and Honors

Start-EndDescription
2014-2016American Heart Association: Postdoctoral Fellowship
2012-2016National Health and Medical Research Council of Australia: CJ Martin Fellowship
2012-2013Royal Australasian College of Physicians: Margorie Hooper Fellowship
2008-2009Pfizer Australia: CardioVascular Lipid Research Grant
2011Cardiac Society of Australia and New Zealand: Fellow (FCSANZ)
2007Royal Australasian College of Physicians: Fellow (FRACP)
2012European Society of Cardiology: Fellow (FESC)
 Research Expertise & Professional Interests
Heart failure
Metabolic heart disease
Mitochondrial function & its redox regulation
Aortic stenosis

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sverdlov AL, Ngo DT. Response to the letter to editor: Galectin-3 and atrial fibrillation. Int J Cardiol. 2017 Feb 15; 229:2. PMID: 27956319.
    View in: PubMed
  2. Chen D, Procter N, Goh V, Liu S, Chua SJ, Assadi-Khansari B, Stewart S, Horowitz JD, Sverdlov AL, Ngo DT. New onset atrial fibrillation is associated with elevated galectin-3 levels. Int J Cardiol. 2016 Nov 15; 223:48-49. PMID: 27529590.
    View in: PubMed
  3. Sverdlov AL, Figtree GA, Horowitz JD, Ngo DT. Interplay between Oxidative Stress and Inflammation in Cardiometabolic Syndrome. Mediators Inflamm. 2016; 2016:8254590. PMID: 27563174.
    View in: PubMed
  4. Amarasekera AT, Sverdlov AL, Horowitz JD, Ngo DT. Elevated parathyroid hormone predicts high asymmetric dimethylarginine (ADMA) concentrations in obese diabetic patients. Diabetes Metab. 2016 Nov; 42(5):378-381. PMID: 27286738.
    View in: PubMed
  5. Sverdlov AL, Elezaby A, Qin F, Behring JB, Luptak I, Calamaras TD, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Bachschmid MM, Colucci WS. Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease. J Am Heart Assoc. 2016 Jan 11; 5(1). PMID: 26755553.
    View in: PubMed
  6. Miller EJ, Calamaras T, Elezaby A, Sverdlov A, Qin F, Luptak I, Wang K, Sun X, Vijay A, Croteau D, Bachschmid M, Cohen RA, Walsh K, Colucci WS. Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge. J Am Heart Assoc. 2015 Dec 31; 5(1). PMID: 26722122.
    View in: PubMed
  7. Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025. PMID: 26642319.
    View in: PubMed
  8. Horowitz JD, Chong CR, Ngo DT, Sverdlov AL. Effects of acute hyperglycaemia on cardiovascular homeostasis: does a spoonful of sugar make the flow-mediated dilatation go down? J Thorac Dis. 2015 Dec; 7(12):E607-11. PMID: 26793371.
    View in: PubMed
  9. Taniguchi Y, Takahashi Y, Toba T, Yamada S, Yokoi K, Kobayashi S, Okajima S, Shimane A, Kawai H, Yasaka Y, Smanio P, Oliveira MA, Machado L, Cestari P, Medeiros E, Fukuzawa S, Okino S, Ikeda A, Maekawa J, Ichikawa S, Kuroiwa N, Yamanaka K, Igarashi A, Inagaki M, Patel K, Mahan M, Ananthasubramaniam K, Mouden M, Yokota S, Ottervanger JP, Knollema S, Timmer JR, Jager PL, Padron K, Peix A, Cabrera LO, Pena Bofill V, Valera D, Rodriguez Nande L, Carrillo Hernandez R, Mena Esnard E, Fernandez Columbie Y, Bertella E, Baggiano A, Mushtaq S, Segurini C, Loguercio M, Conte E, Beltrama V, Petulla' M, Andreini D, Pontone G, Guzic Salobir B, Dolenc Novak M, Jug B, Kacjan B, Novak Z, Vrtovec M, Mushtaq S, Pontone G, Bertella E, Conte E, Segurini C, Volpato V, Baggiano A, Formenti A, Pepi M, Andreini D, Ajanovic R, Husic-Selimovic A, Zujovic-Ajanovic A, Mlynarski R, Mlynarska A, Golba K, Sosnowski M, Ameta D, Goyal M, Kumar D, Chandra S, Sethi R, Puri A, Dwivedi SK, Narain VS, Saran RK, Nekolla S, Rischpler C, Nicolosi S, Langwieser N, Dirschinger R, Laugwitz KL, Schwaiger M, Goral JL, Napoli J, Forcada PJ, Zucchiatti NE, Damico AC, Damico AE, Olivieri DB, Lavorato MA, Dubesarsky EA, Montana OR, Salgado C, Jimenez-Heffernan A, Ramos-Font C, Lopez-Martin J, Sanchez De Mora E, Lopez-Aguilar R, Manovel A, Martinez AB, Rivera F, Soriano E, Maroz-Vadalazhskaya N, Trisvetova E, Vrublevskaya O, Abazid R, Kattea M, Saqqah H, Sayed S, Smettei O, Winther S, Svensson M, Birn H, Jorgensen HS, Botker HE, Ivarsen P, Bottcher M, Maaniitty T, Stenstrom I, Saraste A, Pikkarainen E, Uusitalo V, Ukkonen H, Kajander S, Bax J, Knuuti J, Choi TY, Park HB, Lee CH, Lee JH, Seo YS, Cho YH, Hwang ES, Cho DK, Sanchez Enrique C, Ferrera C, Olmos C, Jimenez-Ballve A, Perez-Castejon MJ, Fernandez C, Vivas D, Vilacosta I, Nagamachi S, Onizuka H, Nishii R, Mizutani Y, Kitamura K, Lo Presti M, Polizzi V, Pino PG, Luzi G, Bellavia D, Fiorilli R, Madeo A, Malouf J, Buffa V, Musumeci F, Rosales S, Puente A, Zafrir N, Shochat T, Mats A, Solodky A, Kornowski R, Lorber A, Boemio A, Pellegrino T, Paolillo S, Piscopo V, Carotenuto R, Russo B, Pellegrino S, De Matteis G, Perrone-Filardi P, Cuocolo A, Piscopo V, Pellegrino T, Boemio A, Carotenuto R, Russo B, Pellegrino S, De Matteis G, Petretta M, Cuocolo A, Amirov N, Ibatullin M, Sadykov A A, Saifullina G, Ruano R, Diego Dominguez M, Rodriguez Gabella T, Diego Nieto A, Diaz Gonzalez LG, Garcia-Talavera JR, Sanchez Fernandez PL, Leen AC, Al Younis I, Zandbergen-Harlaar S, Verberne HJ, Gimelli A, Veltman CE, Wolterbeek R, Bax JJ, Scholte A, Mooney D, Rosenblatt JA, Dunn TL, Vasaiwala SC, Okuda K, Nakajima K, Nystrom K, Edenbrandt L, Matsuo S, Wakabayashi H, Hashimoto M, Kinuya S, Iric-Cupic V, Milanov S, Davidovic G, Zdravkovic V, Ashikaga K, Yoneyama K, Akashi Y, Shugushev Z, Maximkin D, Chepurnoy A, Volkova O, Baranovich V, Faibushevich A, El Tahlawi M, Elmurr A, Alzubaidi S, Sakrana A, Gouda M, El Tahlawi R, Sellem A, Melki S, Elajmi W, Hammami H, Okano M, Kato T, Kimura M, Funasako M, Nakane E, Miyamoto S, Izumi T, Haruna T, Inoko M, Massardo T, Swett E, Fernandez R, Vera V, Zhindon J, Fernandez R, Swett E, Vera V, Zhindon JP, Alay R, Massardo T, Ohshima S, Nishio M, Kojima A, Tamai S, Kobayashi T, Murohara T, Burrell S, Van Rosendael A, Van Den Hoogen I, De Graaf MA, Roelofs J, Kroft LJ, Bax JJ, Scholte AJ, Rjabceva I, Krumina G, Kalvelis A, Chanakhchyan F, Vakhromeeva M, Kankiya E, Koppes J, Knol R, Wondergem M, Van Der Ploeg T, Van Der Zant FM, Lazarenko SV, Bruin VS, Pan XB, Declerck JM, Van Der Zant FM, Knol RJ, Juarez-Orozco LE, Alexanderson E, Slart R, Tio RA, Dierckx RA, Zeebregts CJ, Boersma HH, Hillege HL, Martinez-Aguilar MM, Jordan-Rios A, Christensen TE, Ahtarovski KA, Bang LE, Holmvang L, Soeholm H, Ghotbi AA, Andersson H, Ihlemann N, Kjaer A, Hasbak P, Gulya M, Lishmanov YB, Zavadovskii KW, Lebedev DI, Stahle M, Hellberg S, Liljenback H, Virta J, Metsala O, Yla-Herttuala S, Saukko P, Knuuti J, Saraste A, et al. Poster Session 1: Sunday 3 May 2015, 08:30-18:00Room: Poster Area. Eur Heart J Cardiovasc Imaging. 2015 May; 16 Suppl 1:i11-i28. PMID: 25939923.
    View in: PubMed
  10. Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Wilson S C, Edward J M. Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. J Mol Cell Cardiol. 2015 Feb; 79:275-83. PMID: 25497302.
    View in: PubMed
  11. Procter NE, Chong CR, Sverdlov AL, Chan WP, Chirkov YY, Horowitz JD. Aging of platelet nitric oxide signaling: pathogenesis, clinical implications, and therapeutics. Semin Thromb Hemost. 2014 Sep; 40(6):660-8. PMID: 25173501.
    View in: PubMed
  12. Sverdlov AL, Ngo DT, Chan WP, Chirkov YY, Horowitz JD. Aging of the nitric oxide system: are we as old as our NO? J Am Heart Assoc. 2014 Aug; 3(4). PMID: 25134680.
    View in: PubMed
  13. Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS. High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II. J Mol Cell Cardiol. 2015 Jan; 78:165-73. PMID: 25109264.
    View in: PubMed
  14. Chong CR, Chan WP, Nguyen TH, Liu S, Procter NE, Ngo DT, Sverdlov AL, Chirkov YY, Horowitz JD. Thioredoxin-interacting protein: pathophysiology and emerging pharmacotherapeutics in cardiovascular disease and diabetes. Cardiovasc Drugs Ther. 2014 Aug; 28(4):347-60. PMID: 25088927.
    View in: PubMed
  15. Ahmadian A, Brogan A, Berman J, Sverdlov AL, Mercier G, Mazzini M, Govender P, Ruberg FL, Miller EJ. Quantitative interpretation of FDG PET/CT with myocardial perfusion imaging increases diagnostic information in the evaluation of cardiac sarcoidosis. J Nucl Cardiol. 2014 Oct; 21(5):925-39. PMID: 24879453.
    View in: PubMed
  16. Nguyen TH, Neil CJ, Sverdlov AL, Ngo DT, Chan WP, Heresztyn T, Chirkov YY, Tsikas D, Frenneaux MP, Horowitz JD. Enhanced NO signaling in patients with Takotsubo cardiomyopathy: short-term pain, long-term gain? Cardiovasc Drugs Ther. 2013 Dec; 27(6):541-7. PMID: 23921835.
    View in: PubMed
  17. Dautov RF, Ngo DT, Licari G, Liu S, Sverdlov AL, Ritchie RH, Kemp-Harper BK, Horowitz JD, Chirkov YY. The nitric oxide redox sibling nitroxyl partially circumvents impairment of platelet nitric oxide responsiveness. Nitric Oxide. 2013 Nov 30; 35:72-8. PMID: 24012721.
    View in: PubMed
  18. Sverdlov AL, Chan WP, Procter NE, Chirkov YY, Ngo DT, Horowitz JD. Reciprocal regulation of NO signaling and TXNIP expression in humans: impact of aging and ramipril therapy. Int J Cardiol. 2013 Oct 12; 168(5):4624-30. PMID: 23958415.
    View in: PubMed
  19. Maher AR, Arif S, Madhani M, Abozguia K, Ahmed I, Fernandez BO, Feelisch M, O'Sullivan AG, Christopoulos A, Sverdlov AL, Ngo D, Dautov R, James PE, Horowitz JD, Frenneaux MP. Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite. Br J Pharmacol. 2013 Jun; 169(3):659-70. PMID: 23472879.
    View in: PubMed
  20. Chan WP, Ngo DT, Sverdlov AL, Rajendran S, Stafford I, Heresztyn T, Chirkov YY, Horowitz JD. Premature aging of cardiovascular/platelet function in polycystic ovarian syndrome. Am J Med. 2013 Jul; 126(7):640.e1-7. PMID: 23688663.
    View in: PubMed
  21. Ngo DT, Horowitz JD, Sverdlov AL. Heart failure: a corin-deficient state? Hypertension. 2013 Feb; 61(2):284-5. PMID: 23232647.
    View in: PubMed
  22. Neil C, Nguyen TH, Kucia A, Crouch B, Sverdlov A, Chirkov Y, Mahadavan G, Selvanayagam J, Dawson D, Beltrame J, Zeitz C, Unger S, Redpath T, Frenneaux M, Horowitz J. Slowly resolving global myocardial inflammation/oedema in Tako-Tsubo cardiomyopathy: evidence from T2-weighted cardiac MRI. Heart. 2012 Sep; 98(17):1278-84. PMID: 22791656.
    View in: PubMed
  23. Sverdlov AL, Ngo DT, Chan WP, Chirkov YY, Gersh BJ, McNeil JJ, Horowitz JD. Determinants of aortic sclerosis progression: implications regarding impairment of nitric oxide signalling and potential therapeutics. Eur Heart J. 2012 Oct; 33(19):2419-25. PMID: 22771677.
    View in: PubMed
  24. Ngo DT, Sverdlov AL, Horowitz JD. Prevention of aortic valve stenosis: a realistic therapeutic target? Pharmacol Ther. 2012 Jul; 135(1):78-93. PMID: 22516738.
    View in: PubMed
  25. Sverdlov AL, Ngo DT, Horowitz JD. Redefining the natural history of calcific aortic stenosis: lessons from Laennec. J Intern Med. 2012 Jun; 271(6):569-72. PMID: 22324298.
    View in: PubMed
  26. Neil CJ, Nguyen TH, Sverdlov AL, Chirkov YY, Chong CR, Stansborough J, Beltrame JF, Kucia AM, Zeitz CJ, Frenneaux MP, Horowitz JD. Can we make sense of takotsubo cardiomyopathy? An update on pathogenesis, diagnosis and natural history. Expert Rev Cardiovasc Ther. 2012 Feb; 10(2):215-21. PMID: 22292877.
    View in: PubMed
  27. Sverdlov AL, Ngo DT, Horowitz JD. Pathogenesis of aortic sclerosis: association with low BMI, tissue nitric oxide resistance, but not systemic inflammatory activation. Am J Cardiovasc Dis. 2012; 2(1):43-9. PMID: 22254213.
    View in: PubMed
  28. Nguyen TH, Neil CJ, Sverdlov AL, Mahadavan G, Chirkov YY, Kucia AM, Stansborough J, Beltrame JF, Selvanayagam JB, Zeitz CJ, Struthers AD, Frenneaux MP, Horowitz JD. N-terminal pro-brain natriuretic protein levels in takotsubo cardiomyopathy. Am J Cardiol. 2011 Nov 1; 108(9):1316-21. PMID: 21871590.
    View in: PubMed
  29. Sverdlov AL, Ngo DT, Chapman MJ, Ali OA, Chirkov YY, Horowitz JD. Pathogenesis of aortic stenosis: not just a matter of wear and tear. Am J Cardiovasc Dis. 2011; 1(2):185-99. PMID: 22254198.
    View in: PubMed
  30. Ngo DT, Chan WP, Rajendran S, Heresztyn T, Amarasekera A, Sverdlov AL, O'Loughlin PD, Morris HA, Chirkov YY, Norman RJ, Horowitz JD. Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D. Nitric Oxide. 2011 Oct 30; 25(3):326-30. PMID: 21741493.
    View in: PubMed
  31. Sverdlov AL, Ngo DT, Nightingale AK, Rajendran S, Mishra K, Heresztyn T, Ritchie RH, Marwick TH, Frenneaux MP, Horowitz JD. The endogenous NOS inhibitor asymmetric dimethylarginine (ADMA) predicts LV mass independent of afterload. Nitric Oxide. 2011 Jun 30; 25(1):41-6. PMID: 21550414.
    View in: PubMed
  32. Ling LH, Chik W, Averbuj P, Pati PK, Sverdlov AL, Ngo DT, Morris RG, Sallustio BC, Horowitz JD. Effects of aging, renal dysfunction, left ventricular systolic impairment, and weight on steady state pharmacokinetics of perhexiline. Ther Drug Monit. 2011 Apr; 33(2):251-6. PMID: 21383654.
    View in: PubMed
  33. Ngo DT, Stafford I, Sverdlov AL, Qi W, Wuttke RD, Zhang Y, Kelly DJ, Weedon H, Smith MD, Kennedy JA, Horowitz JD. Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations. Br J Pharmacol. 2011 Feb; 162(3):722-32. PMID: 20958293.
    View in: PubMed
  34. Horowitz JD, Chirkov YY, Kennedy JA, Sverdlov AL. Modulation of myocardial metabolism: an emerging therapeutic principle. Curr Opin Cardiol. 2010 Jul; 25(4):329-34. PMID: 20535068.
    View in: PubMed
  35. Chirkov YY, De Sciscio M, Sverdlov AL, Leslie S, Sage PR, Horowitz JD. Hydralazine does not ameliorate nitric oxide resistance in chronic heart failure. Cardiovasc Drugs Ther. 2010 Apr; 24(2):131-7. PMID: 20490904.
    View in: PubMed
  36. Ngo DT, Sverdlov AL, McNeil JJ, Horowitz JD. Does vitamin D modulate asymmetric dimethylarginine and C-reactive protein concentrations? Am J Med. 2010 Apr; 123(4):335-41. PMID: 20362753.
    View in: PubMed
  37. Nightingale AK, Sverdlov AL, Rajendran S, Mishra K, Heresztyn T, Ngo DT, Horowitz JD. Lack of association between aortic sclerosis and left ventricular hypertrophy in elderly subjects. Int J Cardiol. 2011 Jul 1; 150(1):33-8. PMID: 20236713.
    View in: PubMed
  38. Ngo DT, Sverdlov AL, Willoughby SR, Nightingale AK, Chirkov YY, McNeil JJ, Horowitz JD. Determinants of occurrence of aortic sclerosis in an aging population. JACC Cardiovasc Imaging. 2009 Aug; 2(8):919-27. PMID: 19679278.
    View in: PubMed
  39. Ngo DT, Sverdlov AL, McNeil JJ, Horowitz JD. Correlates of arterial stiffness in an ageing population: role of asymmetric dimethylarginine. Pharmacol Res. 2009 Dec; 60(6):503-7. PMID: 19559793.
    View in: PubMed
  40. Sverdlov AL, Taylor K, Elkington AG, Zeitz CJ, Beltrame JF. Images in cardiovascular medicine. Cardiac magnetic resonance imaging identifies the elusive perivalvular abscess. Circulation. 2008 Jul 1; 118(1):e1-3. PMID: 18591443.
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  41. Ngo DT, Stafford I, Kelly DJ, Sverdlov AL, Wuttke RD, Weedon H, Nightingale AK, Rosenkranz AC, Smith MD, Chirkov YY, Kennedy JA, Horowitz JD. Vitamin D(2) supplementation induces the development of aortic stenosis in rabbits: interactions with endothelial function and thioredoxin-interacting protein. Eur J Pharmacol. 2008 Aug 20; 590(1-3):290-6. PMID: 18585377.
    View in: PubMed
  42. Chan WP, Sverdlov AL, Horowitz JD. Management of the metabolic syndrome in cardiovascular disease. Curr Treat Options Cardiovasc Med. 2008 Feb; 10(1):27-38. PMID: 18325305.
    View in: PubMed
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