Keywords
Last Name

Frederick Lief Ruberg, MD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionCardiovascular Medicine
Address75 E. Newton St Collamore Building
Boston MA 02118
Phone(617) 638-8968
ORCID ORCID Icon0000-0002-6424-4413
Other Positions
TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentRadiology

TitleProgram Director
InstitutionBoston University School of Medicine
DepartmentClinical and Translational Science Institute
DivisionPilot Translational & Clinical Studies Program

TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine

 Research Expertise & Professional Interests
Dr. Ruberg's clinical and research expertise is in the field of cardiac imaging including echocardiography, cardiovascular magnetic resonance imaging (MRI), and cardiac computed tomography (CT). Dr. Ruberg’s research interest is in the application of MRI-based techniques, including MR spectroscopy, to quantify lipid (fat) deposition within the heart and vasculature as it relates to cardiac and vascular dysfunction. He also has a strong interest in amyloid cardiomyopathy, and the utility of cardiac MR in the diagnosis and management of this disease. He has collaborations involving investigators in cardiovascular medicine, biophysics, geriatrics, cardiac surgery, and hematology/oncology.

 Self-Described Keywords
  • amyloidosis
  • Cardiac-Gated Imaging Techniques
  • echocardiography
  • MRI
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Ruberg FL. Cardiac Amyloidosis: A Zebra Hiding in Plain Sight? Circ Cardiovasc Imaging. 2017 Mar; 10(3):e006186. PMID: 28298289.
    View in: PubMed
  2. Arvanitis M, Koch CM, Chan GG, Torres-Arancivia C, LaValley MP, Jacobson DR, Berk JL, Connors LH, Ruberg FL. Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model. JAMA Cardiol. 2017 Mar 01; 2(3):305-313. PMID: 28196196.
    View in: PubMed
  3. Di Carli MF, Davidoff R, Beerbaum P, Dorbala S, Gillam LD, Hoffmann U, Raman SV, Ruberg FL. Editor's Note. Circ Cardiovasc Imaging. 2017 Mar; 10(3). PMID: 28289023.
    View in: PubMed
  4. Buxbaum JN, Ruberg FL. Transthyretin V122I (pV142I)* cardiac amyloidosis: an age-dependent autosomal dominant cardiomyopathy too common to be overlooked as a cause of significant heart disease in elderly African Americans. Genet Med. 2017 Jan 19. PMID: 28102864.
    View in: PubMed
  5. Salinaro F, Meier-Ewert HK, Miller EJ, Pandey S, Sanchorawala V, Berk JL, Seldin DC, Ruberg FL. Longitudinal systolic strain, cardiac function improvement, and survival following treatment of light-chain (AL) cardiac amyloidosis. Eur Heart J Cardiovasc Imaging. 2016 Dec 12. PMID: 27965280.
    View in: PubMed
  6. Ruberg FL, Fontana M, Gillmore JD. Should Histologic Determination of Amyloid Load Determine Management Decisions in Light-Chain Amyloidosis? J Am Coll Cardiol. 2016 Dec 06; 68(22):2493-2494. PMID: 27908360.
    View in: PubMed
  7. Castano A, Haq M, Narotsky DL, Goldsmith J, Weinberg RL, Morgenstern R, Pozniakoff T, Ruberg FL, Miller EJ, Berk JL, Dispenzieri A, Grogan M, Johnson G, Bokhari S, Maurer MS. Multicenter Study of Planar Technetium 99m Pyrophosphate Cardiac Imaging: Predicting Survival for Patients With ATTR Cardiac Amyloidosis. JAMA Cardiol. 2016 Nov 01; 1(8):880-889. PMID: 27557400.
    View in: PubMed
  8. Haq M, Pawar S, Berk JL, Miller EJ, Ruberg FL. Can 99m-Tc-Pyrophosphate Aid in Early Detection of Cardiac Involvement in Asymptomatic Variant TTR Amyloidosis? JACC Cardiovasc Imaging. 2016 Aug 20. PMID: 27568122.
    View in: PubMed
  9. Ahmadian A, Pawar S, Govender P, Berman J, Ruberg FL, Miller EJ. The response of FDG uptake to immunosuppressive treatment on FDG PET/CT imaging for cardiac sarcoidosis. J Nucl Cardiol. 2016 Jul 25. PMID: 27457527.
    View in: PubMed
  10. Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, Wechalekar AD, Berk JL, Quarta CC, Grogan M, Lachmann HJ, Bokhari S, Castano A, Dorbala S, Johnson GB, Glaudemans AW, Rezk T, Fontana M, Palladini G, Milani P, Guidalotti PL, Flatman K, Lane T, Vonberg FW, Whelan CJ, Moon JC, Ruberg FL, Miller EJ, Hutt DF, Hazenberg BP, Rapezzi C, Hawkins PN. Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis. Circulation. 2016 Jun 14; 133(24):2404-12. PMID: 27143678.
    View in: PubMed
  11. Jefferson AL, Gifford KA, Acosta LM, Bell SP, Donahue MJ, Davis LT, Gottlieb J, Gupta DK, Hohman TJ, Lane EM, Libon DJ, Mendes LA, Niswender K, Pechman KR, Rane S, Ruberg FL, Su YR, Zetterberg H, Liu D. The Vanderbilt Memory & Aging Project: Study Design and Baseline Cohort Overview. J Alzheimers Dis. 2016 03 08; 52(2):539-59. PMID: 26967211.
    View in: PubMed
  12. Connors LH, Sam F, Skinner M, Salinaro F, Sun F, Ruberg FL, Berk JL, Seldin DC. Heart Failure Resulting From Age-Related Cardiac Amyloid Disease Associated With Wild-Type Transthyretin: A Prospective, Observational Cohort Study. Circulation. 2016 Jan 19; 133(3):282-90. PMID: 26660282.
    View in: PubMed
  13. Ruberg FL, Nezafat R. Cardiovascular Magnetic Resonance Visualization of Cardiac Amyloid Infiltration: Challenges and Opportunities. Circulation. 2015 Oct 20; 132(16):1525-7. PMID: 26362630.
    View in: PubMed
  14. Hohman TJ, Samuels LR, Liu D, Gifford KA, Mukherjee S, Benson EM, Abel T, Ruberg FL, Jefferson AL. Stroke risk interacts with Alzheimer's disease biomarkers on brain aging outcomes. Neurobiol Aging. 2015 Sep; 36(9):2501-8. PMID: 26119224.
    View in: PubMed
  15. Ruberg FL, Berk JL, Semigan MJ. V122I transthyretin variant in elderly black Americans. N Engl J Med. 2015 Apr 30; 372(18):1768. PMID: 25923563.
    View in: PubMed
  16. Jefferson AL, Hohman TJ, Liu D, Haj-Hassan S, Gifford KA, Benson EM, Skinner JS, Lu Z, Sparling J, Sumner EC, Bell S, Ruberg FL. Adverse vascular risk is related to cognitive decline in older adults. J Alzheimers Dis. 2015; 44(4):1361-73. PMID: 25471188.
    View in: PubMed
  17. Ahmadian A, Brogan A, Berman J, Sverdlov AL, Mercier G, Mazzini M, Govender P, Ruberg FL, Miller EJ. Quantitative interpretation of FDG PET/CT with myocardial perfusion imaging increases diagnostic information in the evaluation of cardiac sarcoidosis. J Nucl Cardiol. 2014 Oct; 21(5):925-39. PMID: 24879453.
    View in: PubMed
  18. Hua N, Chen Z, Phinikaridou A, Pham T, Qiao Y, LaValley MP, Bigornia SJ, Ruth MR, Apovian CM, Ruberg FL, Hamilton JA. The influence of pericardial fat upon left ventricular function in obese females: evidence of a site-specific effect. J Cardiovasc Magn Reson. 2014; 16:37. PMID: 24884541.
    View in: PubMed
  19. Berman JS, Govender P, Ruberg FL, Mazzini M, Miller EJ. Scadding revisited: a proposed staging system for cardiac sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2014; 31(1):2-5. PMID: 24751447.
    View in: PubMed
  20. Girnius S, Seldin DC, Meier-Ewert HK, Sloan JM, Quillen K, Ruberg FL, Berk JL, Doros G, Sanchorawala V. Safety and efficacy of high-dose melphalan and auto-SCT in patients with AL amyloidosis and cardiac involvement. Bone Marrow Transplant. 2014 Mar; 49(3):434-9. PMID: 24317129.
    View in: PubMed
  21. Ruberg FL. T1 mapping in cardiac amyloidosis: can we get there from here? JACC Cardiovasc Imaging. 2013 Apr; 6(4):498-500. PMID: 23498671.
    View in: PubMed
  22. Ruberg FL, Miller EJ. Nuclear tracers for transthyretin cardiac amyloidosis: time to bone up? Circ Cardiovasc Imaging. 2013 Mar 1; 6(2):162-4. PMID: 23512778.
    View in: PubMed
  23. Tsai SB, Seldin DC, Quillen K, Berk JL, Ruberg FL, Meier-Ewert H, Sloan JM, Doros G, Finn KT, Skinner M, Sanchorawala V. High-dose melphalan and stem cell transplantation for patients with AL amyloidosis: trends in treatment-related mortality over the past 17 years at a single referral center. Blood. 2012 Nov 22; 120(22):4445-6. PMID: 23175664.
    View in: PubMed
  24. Ruberg FL, Berk JL. Transthyretin (TTR) cardiac amyloidosis. Circulation. 2012 Sep 4; 126(10):1286-300. PMID: 22949539.
    View in: PubMed
  25. Ruberg FL, Maurer MS, Judge DP, Zeldenrust S, Skinner M, Kim AY, Falk RH, Cheung KN, Patel AR, Pano A, Packman J, Grogan DR. Prospective evaluation of the morbidity and mortality of wild-type and V122I mutant transthyretin amyloid cardiomyopathy: the Transthyretin Amyloidosis Cardiac Study (TRACS). Am Heart J. 2012 Aug; 164(2):222-228.e1. PMID: 22877808.
    View in: PubMed
  26. Freeman B, Sloan JM, Seldin DC, Cowan AJ, Ruberg FL, Sanchorawala V. Multiple arterial and venous thromboembolic complications in AL amyloidosis and cardiac involvement: a case report and literature review. Amyloid. 2012 Sep; 19(3):156-60. PMID: 22680044.
    View in: PubMed
  27. Meier-Ewert HK, Sanchorawala V, Berk JL, Ruberg FL. Cardiac amyloidosis: evolving approach to diagnosis and management. Curr Treat Options Cardiovasc Med. 2011 Dec; 13(6):528-42. PMID: 21989745.
    View in: PubMed
  28. Cibeira MT, Sanchorawala V, Seldin DC, Quillen K, Berk JL, Dember LM, Segal A, Ruberg F, Meier-Ewert H, Andrea NT, Sloan JM, Finn KT, Doros G, Blade J, Skinner M. Outcome of AL amyloidosis after high-dose melphalan and autologous stem cell transplantation: long-term results in a series of 421 patients. Blood. 2011 Oct 20; 118(16):4346-52. PMID: 21828140.
    View in: PubMed
  29. Seldin DC, Andrea N, Berenbaum I, Berk JL, Connors L, Dember LM, Doros G, Fennessey S, Finn K, Girnius S, Lerner A, Libbey C, Meier-Ewert HK, O'Connell R, O'Hara C, Quillen K, Ruberg FL, Sam F, Segal A, Shelton A, Skinner M, Sloan JM, Wiesman JF, Sanchorawala V. High-dose melphalan and autologous stem cell transplantation for AL amyloidosis: recent trends in treatment-related mortality and 1-year survival at a single institution. Amyloid. 2011 Jun; 18 Suppl 1:127-9. PMID: 21838459.
    View in: PubMed
  30. Meier-Ewert HK, Sanchorawala V, Berk J, Finn KT, Skinner M, Seldin DC, Ruberg FL. Regression of cardiac wall thickness following chemotherapy and stem cell transplantation for light chain (AL) amyloidosis. Amyloid. 2011 Jun; 18 Suppl 1:130-1. PMID: 21838460.
    View in: PubMed
  31. Tsai SB, Seldin DC, Wu H, O'Hara C, Ruberg FL, Sanchorawala V. Myocardial infarction with "clean coronaries" caused by amyloid light-chain AL amyloidosis: a case report and literature review. Amyloid. 2011 Sep; 18(3):160-4. PMID: 21504342.
    View in: PubMed
  32. Bhuiyan T, Helmke S, Patel AR, Ruberg FL, Packman J, Cheung K, Grogan D, Maurer MS. Pressure-volume relationships in patients with transthyretin (ATTR) cardiac amyloidosis secondary to V122I mutations and wild-type transthyretin: Transthyretin Cardiac Amyloid Study (TRACS). Circ Heart Fail. 2011 Mar; 4(2):121-8. PMID: 21191093.
    View in: PubMed
  33. Ruberg FL. Paying at the pump: diet-induced accumulation of cardiac lipid and systolic dysfunction. Circ Cardiovasc Imaging. 2010 Nov; 3(6):635-7. PMID: 21081742.
    View in: PubMed
  34. Amsterdam EA, Kirk JD, Bluemke DA, Diercks D, Farkouh ME, Garvey JL, Kontos MC, McCord J, Miller TD, Morise A, Newby LK, Ruberg FL, Scordo KA, Thompson PD. Testing of low-risk patients presenting to the emergency department with chest pain: a scientific statement from the American Heart Association. Circulation. 2010 Oct 26; 122(17):1756-76. PMID: 20660809.
    View in: PubMed
  35. Phinikaridou A, Ruberg FL, Hallock KJ, Qiao Y, Hua N, Viereck J, Hamilton JA. In vivo detection of vulnerable atherosclerotic plaque by MRI in a rabbit model. Circ Cardiovasc Imaging. 2010 May; 3(3):323-32. PMID: 20194634.
    View in: PubMed
  36. Ruberg FL, Chen Z, Hua N, Bigornia S, Guo Z, Hallock K, Jara H, LaValley M, Phinikaridou A, Qiao Y, Viereck J, Apovian CM, Hamilton JA. The relationship of ectopic lipid accumulation to cardiac and vascular function in obesity and metabolic syndrome. Obesity (Silver Spring). 2010 Jun; 18(6):1116-21. PMID: 19875992.
    View in: PubMed
  37. Ruberg FL, Judge DP, Maurer MS. Familial amyloid cardiomyopathy due to TTR mutations: an underdiagnosed cause of restrictive cardiomyopathy [corrected]. J Card Fail. 2009 Jun; 15(5):464. PMID: 19477408.
    View in: PubMed
  38. Ruberg FL, Appelbaum E, Davidoff R, Ozonoff A, Kissinger KV, Harrigan C, Skinner M, Manning WJ. Diagnostic and prognostic utility of cardiovascular magnetic resonance imaging in light-chain cardiac amyloidosis. Am J Cardiol. 2009 Feb 15; 103(4):544-9. PMID: 19195518.
    View in: PubMed
  39. Goyal SK, Punnam SR, Verma G, Ruberg FL. Persistent left superior vena cava: a case report and review of literature. Cardiovasc Ultrasound. 2008; 6:50. PMID: 18847480.
    View in: PubMed
  40. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, O'Donnell CJ, Fox CS. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation. 2008 Feb 5; 117(5):605-13. PMID: 18212276.
    View in: PubMed
  41. Dinwoodey DL, Skinner M, Maron MS, Davidoff R, Ruberg FL. Light-chain amyloidosis with echocardiographic features of hypertrophic cardiomyopathy. Am J Cardiol. 2008 Mar 1; 101(5):674-6. PMID: 18308019.
    View in: PubMed
  42. Ruberg FL. Myocardial lipid accumulation in the diabetic heart. Circulation. 2007 Sep 4; 116(10):1110-2. PMID: 17768302.
    View in: PubMed
  43. Qiao Y, Ronen I, Viereck J, Ruberg FL, Hamilton JA. Identification of atherosclerotic lipid deposits by diffusion-weighted imaging. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1440-6. PMID: 17379838.
    View in: PubMed
  44. Ruberg FL, McDonnell ME, Trabb J, Shemin RJ, Hoyt RF, Braverman LE, Balady GJ. An intracardiac accessory thyroid gland. Am J Cardiol. 2006 Mar 15; 97(6):926-8. PMID: 16516604.
    View in: PubMed
  45. Davidoff R, Ruberg FL. Newer cardiac imaging techniques: multidetector CT angiography. J Insur Med. 2006; 38(2):116-25. PMID: 16845845.
    View in: PubMed
  46. Ruberg FL, Loscalzo J. Normal Mechanisms of Hemostasis. In: Loscalzo J, Dzau V, and Creager M, eds. Vascular Medicine, A Companion to Braunwald’s Heart Disease. Saunders/Elsevier. Philadelphia. 2006; 61-70.
  47. Ruberg FL, Viereck J, Phinikaridou A, Qiao Y, Loscalzo J, Hamilton JA. Identification of cholesteryl esters in human carotid atherosclerosis by ex vivo image-guided proton MRS. J Lipid Res. 2006 Feb; 47(2):310-7. PMID: 16317172.
    View in: PubMed
  48. Ruberg FL, Kissinger KV, Manning WJ. Images in cardiovascular medicine. Diaphragmatic motion during Cheyne-Stokes respiration by navigator magnetic resonance imaging. Circulation. 2005 Sep 6; 112(10):e132. PMID: 16145007.
    View in: PubMed
  49. Ruberg FL, Loscalzo J. Vascular Thromboresistance and the Genetics of Thrombotic Risk. In: Becker RC and Harrington RA, eds. Clinical, Interventional and Investigational Thrombocardiology. Taylor and Francis. London. 2005; 31-53.
  50. Ruberg FL, Loscalzo J. Inflammation and Atherothrombosis. In: Loscalzo J, ed. Molecular Mechanisms of Atherosclerosis. Taylor and Francis. London. 2005; 45-60.
  51. Ruberg FL. Computed Tomography of the Coronary Arteries. Book Review: Circulation 112:e7-8. 2005.
  52. Viereck J, Ruberg FL, Qiao Y, Perez AS, Detwiller K, Johnstone M, Hamilton JA. MRI of atherothrombosis associated with plaque rupture. Arterioscler Thromb Vasc Biol. 2005 Jan; 25(1):240-5. PMID: 15528478.
    View in: PubMed
  53. Ruberg FL, Leopold JA, Loscalzo J. Atherothrombosis: plaque instability and thrombogenesis. Prog Cardiovasc Dis. 2002 Mar-Apr; 44(5):381-94. PMID: 12024336.
    View in: PubMed
  54. Ruberg FL, Loscalzo J. Prothrombotic determinants of coronary atherothrombosis. Vasc Med. 2002; 7(4):289-99. PMID: 12710845.
    View in: PubMed
  55. O'Brien CD, Ji G, Wang YX, Sun J, Krymskaya VP, Ruberg FL, Kotlikoff MI, Albelda SM. PECAM-1 (CD31) engagement activates a phosphoinositide-independent, nonspecific cation channel in endothelial cells. FASEB J. 2001 May; 15(7):1257-60. PMID: 11344106.
    View in: PubMed
  56. Gurubhagavatula I, Amrani Y, Pratico D, Ruberg FL, Albelda SM, Panettieri RA. Engagement of human PECAM-1 (CD31) on human endothelial cells increases intracellular calcium ion concentration and stimulates prostacyclin release. J Clin Invest. 1998 Jan 1; 101(1):212-22. PMID: 9421484.
    View in: PubMed
  57. Ruberg FL, Skene DJ, Hanifin JP, Rollag MD, English J, Arendt J, Brainard GC. Melatonin regulation in humans with color vision deficiencies. J Clin Endocrinol Metab. 1996 Aug; 81(8):2980-5. PMID: 8768862.
    View in: PubMed
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