Frederick Lief Ruberg, MD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine

MD, University of Pennsylvania School of Medicine



Dr. Ruberg's clinical and research expertise is in the field of cardiac imaging including echocardiography, cardiovascular magnetic resonance imaging (MRI), and cardiac computed tomography (CT). Dr. Ruberg’s research interest is in the application of MRI-based techniques, including MR spectroscopy, to quantify lipid (fat) deposition within the heart and vasculature as it relates to cardiac and vascular dysfunction. He also has a strong interest in amyloid cardiomyopathy, and the utility of cardiac MR in the diagnosis and management of this disease. He has collaborations involving investigators in cardiovascular medicine, biophysics, geriatrics, cardiac surgery, and hematology/oncology.

Associate Professor
Boston University School of Medicine
Radiology


Program Director
Boston University School of Medicine
Clinical and Translational Science Institute
Pilot Translational & Clinical Studies Program

Active Staff Privileges
Boston Medical Center
Medicine




Molecular Imaging of Primary Amyloid Cardiomyopathy
04/01/2017 - 03/31/2018 (PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL130563-02


Longitudinal strain in ATTR cardiac amyloidosis
09/25/2017 - 09/25/2020 (PI)
Eidos Therapeutics

Serum Biomarker identification of cardiac amyloidosis in elderly African Americans
04/15/2015 - 03/31/2017 (PI)
NIH-NIA

Cardiac Function as a mechanism for maladaptive brain aging (Supplement)
09/01/2015 - 04/30/2016 (PI)
Vanderbilt University Medical Center NIH-NIA

Cardiac Function as a Mechanism for Maladaptive Brain Aging
07/01/2014 - 04/30/2016 (PI)
Vanderbilt University Medical Center NIH-NIA

Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE)
02/01/2011 - 04/30/2015 (PI)
Duke University NIH-NHLBI

Oxidant stress, Matrix remodeling and stem cell transplant in cardiac amyloidosis
01/01/2010 - 12/31/2014 (PI)
American Heart Assoc

Ventricular Remodeling in Cardiac Amyloidosis Following Stem Cell Transplantation: A Cardiovascular
12/01/2009 - 06/30/2014 (PI)
Amyloidosis Foundation


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Arvanitis M, Chan GG, Jacobson DR, Berk JL, Connors LH, Ruberg FL. Prevalence of mutant ATTR cardiac amyloidosis in elderly African Americans with heart failure. Amyloid. 2017 Oct 20; 1-3.View Related Profiles. PMID: 29052438.
  2. Salinaro F, Meier-Ewert HK, Miller EJ, Pandey S, Sanchorawala V, Berk JL, Seldin DC, Ruberg FL. Longitudinal systolic strain, cardiac function improvement, and survival following treatment of light-chain (AL) cardiac amyloidosis. Eur Heart J Cardiovasc Imaging. 2017 Sep 01; 18(9):1057-1064.View Related Profiles. PMID: 27965280; DOI: 10.1093/ehjci/jew298;.
  3. Arun M, Brauneis D, Doros G, Shelton AC, Sloan JM, Quillen K, Ruberg FL, Sanchorawala V, Varga C. The incidence of atrial fibrillation among patients with AL amyloidosis undergoing high-dose melphalan and stem cell transplantation: experience at a single institution. Bone Marrow Transplant. 2017 Sep; 52(9):1349-1351.View Related Profiles. PMID: 28737773.
  4. Siddiqi OK, Ruberg FL. Cardiac amyloidosis: An update on pathophysiology, diagnosis, and treatment. Trends Cardiovasc Med. 2017 Jul 13.View Related Profiles. PMID: 28739313.
  5. Siddiqi OK, Ruberg FL. Challenging the myths of cardiac amyloidosis. Eur Heart J. 2017 Jun 21; 38(24):1909-1912.View Related Profiles. PMID: 28444296; DOI: 10.1093/eurheartj/ehx210;.
  6. Ruberg FL. Cardiac Amyloidosis: A Zebra Hiding in Plain Sight? Circ Cardiovasc Imaging. 2017 Mar; 10(3):e006186. PMID: 28298289; DOI: 10.1161/CIRCIMAGING.117.006186;.
  7. Arvanitis M, Koch CM, Chan GG, Torres-Arancivia C, LaValley MP, Jacobson DR, Berk JL, Connors LH, Ruberg FL. Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model. JAMA Cardiol. 2017 Mar 01; 2(3):305-313.View Related Profiles. PMID: 28196196; DOI: 10.1001/jamacardio.2016.5864;.
  8. Di Carli MF, Davidoff R, Beerbaum P, Dorbala S, Gillam LD, Hoffmann U, Raman SV, Ruberg FL. Editor''s Note. Circ Cardiovasc Imaging. 2017 Mar; 10(3).View Related Profiles. PMID: 28289023; DOI: 10.1161/CIRCIMAGING.117.006334;.
  9. Arvanitis M, Simon S, Chan G, Fine D, Beardsley P, LaValley M, Jacobson D, Koch C, Berk JL, Connors LH, Ruberg FL. Retinol binding protein 4 (RBP4) concentration identifies V122I transthyretin cardiac amyloidosis. Amyloid. 2017 Mar; 24(sup1):120-121.View Related Profiles. PMID: 28434357; DOI: 10.1080/13506129.2017.1295371;.
  10. Maurer M, Lousada I, Hanna M, Ruberg F, Mohty D, Dispenzieri A, Liedtke M, Paulson I, Vest J, Grogan M. Recommendations from the Amyloidosis Research Consortium Educational Roundtable at the American College of Cardiology Annual Meeting, 1 April 2016. Amyloid. 2017 Mar; 24(sup1):165-166. PMID: 28434366; DOI: 10.1080/13506129.2017.1286582;.
Showing 10 of 63 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 63 publications over 18 distinct years, with a maximum of 11 publications in 2017

YearPublications
19961
19981
20011
20022
20041
20055
20063
20073
20083
20092
20104
20115
20124
20133
20143
20155
20166
201711
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

amyloidosis
Cardiac-Gated Imaging Techniques
echocardiography
MRI

Dr. Ruberg is the Director, Pilot Grants Program, BU CTSI and an Associate Professor of Medicine and Radiology at Boston University School of Medicine. Dr. Ruberg is also the Director of the Cardiovascular Medicine Fellowship Training Program. An active clinical cardiologist and investigator, Dr. Ruberg’s commitment to interdisciplinary research and team science is exemplified by his various responsibilities at BUMC. He is the Director of the Advanced Cardiac Imaging Program at Boston Medical Center – a clinical service involving clinicians and trainees in the Departments of Radiology and Medicine. His clinical interest is in infiltrative cardiomyopathy and he is a participating clinician and researcher in the multi-disciplinary BU Amyloidosis Center and Sarcoidosis Center. He is a nationally recognized expert in cardiac amyloidosis. His clinical and research expertise is in the field of cardiac imaging with interest in refining quantitative MR techniques for application in the clinical care of infiltrative cardiomyopathies. His research has been funded by the American Heart Association (AHA), Amyloidosis Foundation, and NIH. In addition to his own grant awards, Dr. Ruberg is also co-investigator on both BUMC and outside BMC collaborative projects, including the NIH-funded Vanderbilt Memory and Alzheimer’s Center. Dr. Ruberg is a peer reviewer for numerous journals including Circulation, Annals of Internal Medicine, Journal of the American College of Cardiology, and JACC: Cardiovascular Imaging. He has served as an NIH peer reviewer and is a member of the editorial board of Circulation: Cardiovascular Imaging. Dr. Ruberg is a fellow of the American College of Cardiology and the AHA. Dr. Ruberg is an active mentor of Internal Medicine residents and Cardiovascular Medicine fellows. Past projects have involved cardiac imaging and past mentees have reported finding at the major national Cardiology meetings and published reports in the peer reviewed literature.

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Diversity Mentor
  • Project Mentor
  • Research / Scholarly Mentor
  • Work / Life Integration Mentor
Contact for Mentoring:
  • Email (see 'Contact Info')


75 E. Newton St Collamore Building
Boston MA 02118
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