Vasan S. Ramachandran, MD
Boston University School of Medicine
Dept of Medicine
Preventive Medicine & Epidemiology Section

MD, All India Institute of Medical Sciences
MBBS, All India Institute of Medical Sciences
DM, All India Institute of Medical Sciences

For the last 18 years, I have focused my research on 4 inter-related areas. Briefly, these areas include:

a. Clinical and genetic epidemiology of congestive heart failure (CHF), including identifying risk factors for the disease, characterizing the subgroups with diastolic heart failure, asymptomatic LV systolic and diastolic dysfunction, and evaluating the role of LV remodeling; characterizing the genetic and clinical epidemiology of CHF and its subsets.

b. Clinical and genetic epidemiology of population-based vascular testing and echocardiography, including identifying biological, environmental, and genetic determinants (correlates) of cardiac structure and function; normative standards; detailed assessment of biomarkers of the process of left ventricular (LV) remodeling, including but not limited to role of natriuretic peptides, insulin resistance, cardiac extracellular matrix markers, oxidative stress, inflammation, growth factors; heritability of echocardiographic measurements, and genetic linkage; genes involved in LV remodeling, left atrial and aortic structure identified via genome-wide association Studies (GWAS) and gene-environment interactions; brachial artery endothelial function, its correlates, and tonometric assessment of large artery function.

c. Clinical and genetic epidemiology of cardiovascular risk factors, including high blood pressure, including characterizing the lifetime risk, rates of progression and risks associated with various degrees of elevation of CVD risk factors; large artery stiffness and function and role in systolic hypertension in the elderly; genetics of hypertension and large artery function.

d. Clinical and genetic epidemiology of exercise test responses in asymptomatic individuals and prognostic information; relations to endothelial and vascular function.

Section Chief
Boston University School of Medicine
Department of Medicine
Preventive Medicine & Epidemiology Section

Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences

Co-Director, Echocardiography/Vascular Laboratory
Framingham Heart Study

Multidisciplinary Training Program in Cardiovascular Epidemiology
04/01/2016 - 03/31/2018 (PI)
NIH/National Heart, Lung, and Blood Institute

Framingham Heart Study
09/25/2015 - 03/31/2018 (PI)
NIH/National Heart, Lung, and Blood Institute

Framingham Heart Study
05/07/2015 - 03/31/2018 (PI)
NIH/National Heart, Lung, and Blood Institute

Lipid Biomarkers for Diabetic Heart Disease
04/15/2012 - 02/28/2018 (PI)
Washington University NIH

Cardiac Microstructure and heart failure risk in the Community
04/01/2016 - 01/31/2018 (PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI

Molecular and Genetic Epidimiology of Lipoprotein (A)-Mediated Calcific Aortic Valve Disease
01/01/2017 - 12/31/2017 (PI)
McGill University Health Center NIH NHLBI

Cardiovascular Genome Phenome Study
01/01/2014 - 11/30/2017 (PI)
American Heart Association

Vascular Stiffness as a Precursor of Hypertension in a Middle-aged Cohort
08/01/2015 - 06/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute

Consortium to Study the Genetics of Longevity
06/01/2015 - 06/30/2017 (Co-PI)
PI: Sudha Seshadri, MD
Sutter Bay Hospitals dba California Pacific Medical Center NIH NIA

Integrating Lipid Genotypes and Phenotypes in iPS Delivered Hepatocytes/Adipocytes
07/05/2011 - 06/30/2017 (PI)
Massachusetts General Hospital NIH NHLBI

Showing 10 of 36 results. Show All Results

Population-Based Reference Ranges for Estradiol and Estrone in Men
04/07/2012 - 07/31/2012 (Activity-level PI)
PI: Shalender Bhasin, MBBS
1R01 DK092938-01A1

Yr Title Project-Sub Proj Pubs
2017 Cardiometabolic Outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS) 1R01HL136266-01
2017 Multidisciplinary Training Program in Cardiovascular Epidemiology 5T32HL125232-02
2017 Multidisciplinary Training Program in Cardiovascular Epidemiology 3T32HL125232-01A1S1
2017 Comprehensive Metabolic Profiling of Exercise to Predict Cardiometabolic Risk 5R01HL131029-02 4
2017 Clinical, genetic and cardiometabolic risk correlates of the gut microbiome 5R01HL131015-02
2016 Proteomic Pathway Discovery in Cardiovascular Disease 1R01HL132320-01
2016 Multidisciplinary Training Program in Cardiovascular Epidemiology 1T32HL125232-01A1
2016 IGF::OT::IGF FRAMINGHAM HEART STUDY (FHS) - TASK ORDER 01 268201500001I-2-26800001-1
2016 Clinical, genetic and cardiometabolic risk correlates of the gut microbiome 1R01HL131015-01
2016 Comprehensive Metabolic Profiling of Exercise to Predict Cardiometabolic Risk 1R01HL131029-01 4
Showing 10 of 63 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Jensen MK, Jensen RA, Mukamal KJ, Guo X, Yao J, Sun Q, Cornelis M, Liu Y, Chen MH, Kizer JR, Djoussé L, Siscovick DS, Psaty BM, Zmuda JM, Rotter JI, Garcia M, Harris T, Chen I, Goodarzi MO, Nalls MA, Keller M, Arnold AM, Newman AB, Hoogeveen RC, Rexrode KM, Rimm EB, Hu FB, Ramachandran VS, Katz R, Pankow JS, Ix JH. Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Hum Mol Genet. 2017 Jun 01; 26(11):2156-2163. PMID: 28379451.
  2. Weinstein G, Preis SR, Beiser AS, Kaess B, Chen TC, Satizabal C, Rahman F, Benjamin EJ, Ramachandran VS, Seshadri S. Clinical and Environmental Correlates of Serum BDNF: A descriptive study with plausible implications for AD research. Curr Alzheimer Res. 2017 Feb 02.View Related Profiles. PMID: 28164772; DOI: 10.2174/1567205014666170203094520;.
  3. Chatterjee R, Davenport CA, Svetkey LP, Batch BC, Lin PH, Ramachandran VS, Fox ER, Harman J, Yeh HC, Selvin E, Correa A, Butler K, Edelman D. Serum potassium is a predictor of incident diabetes in African Americans with normal aldosterone: the Jackson Heart Study. Am J Clin Nutr. 2017 Feb; 105(2):442-449. PMID: 27974310; DOI: 10.3945/ajcn.116.143255;.
  4. Ko D, Riles EM, Marcos EG, Magnani JW, Lubitz SA, Lin H, Long MT, Schnabel RB, McManus DD, Ellinor PT, Ramachandran VS, Wang TJ, Gerszten RE, Benjamin EJ, Yin X, Rienstra M. Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study). Am J Cardiol. 2016 Nov 15; 118(10):1493-1496.View Related Profiles. PMID: 27666170; DOI: 10.1016/j.amjcard.2016.08.010;.
  5. Vasan RS, Benjamin EJ. The Future of Cardiovascular Epidemiology. Circulation. 2016 Jun 21; 133(25):2626-33.View Related Profiles. PMID: 27324358; PMCID: PMC4974092; DOI: 10.1161/CIRCULATIONAHA.116.023528;.
  6. Maillard P, Mitchell GF, Himali JJ, Beiser A, Tsao CW, Pase MP, Satizabal CL, Vasan RS, Seshadri S, DeCarli C. Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study. Stroke. 2016 Apr; 47(4):1030-6.View Related Profiles. PMID: 26965846; PMCID: PMC4811686; DOI: 10.1161/STROKEAHA.116.012949;.
  7. Dehghan A, Bis JC, White CC, Smith AV, Morrison AC, Cupples LA, Trompet S, Chasman DI, Lumley T, Völker U, Buckley BM, Ding J, Jensen MK, Folsom AR, Kritchevsky SB, Girman CJ, Ford I, Dörr M, Salomaa V, Uitterlinden AG, Eiriksdottir G, Vasan RS, Franceschini N, Carty CL, Virtamo J, Demissie S, Amouyel P, Arveiler D, Heckbert SR, Ferrières J, Ducimetière P, Smith NL, Wang YA, Siscovick DS, Rice KM, Wiklund PG, Taylor KD, Evans A, Kee F, Rotter JI, Karvanen J, Kuulasmaa K, Heiss G, Kraft P, Launer LJ, Hofman A, Markus MR, Rose LM, Silander K, Wagner P, Benjamin EJ, Lohman K, Stott DJ, Rivadeneira F, Harris TB, Levy D, Liu Y, Rimm EB, Jukema JW, Völzke H, Ridker PM, Blankenberg S, Franco OH, Gudnason V, Psaty BM, Boerwinkle E, O'Donnell CJ. Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort Studies: The CHARGE Consortium. PLoS One. 2016; 11(3):e0144997.View Related Profiles. PMID: 26950853; PMCID: PMC4780701; DOI: 10.1371/journal.pone.0144997;.
  8. Foster MC, Coresh J, Hsu CY, Xie D, Levey AS, Nelson RG, Eckfeldt JH, Vasan RS, Kimmel PL, Schelling J, Simonson M, Sondheimer JH, Anderson AH, Akkina S, Feldman HI, Kusek JW, Ojo AO, Inker LA. Serum ß-Trace Protein and ß2-Microglobulin as Predictors of ESRD, Mortality, and Cardiovascular Disease in Adults With CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2016 Jul; 68(1):68-76. PMID: 26948990; PMCID: PMC4921300; DOI: 10.1053/j.ajkd.2016.01.015;.
  9. Ljungman PL, Wilker EH, Rice MB, Austin E, Schwartz J, Gold DR, Koutrakis P, Benjamin EJ, Vita JA, Mitchell GF, Vasan RS, Hamburg NM, Mittleman MA. The Impact of Multipollutant Clusters on the Association Between Fine Particulate Air Pollution and Microvascular Function. Epidemiology. 2016 Mar; 27(2):194-201.View Related Profiles. PMID: 26562062; DOI: 10.1097/EDE.0000000000000415;.
  10. Travison TG, O''Donnell CJ, Bhasin S, Massaro JM, Hoffmann U, Vasan RS, D''Agostino RB, Basaria S. Circulating Sex Steroids and Vascular Calcification in Community-Dwelling Men: The Framingham Heart Study. J Clin Endocrinol Metab. 2016 May; 101(5):2160-7.View Related Profiles. PMID: 26930184; PMCID: PMC4870846; DOI: 10.1210/jc.2015-4299;.
Showing 10 of 668 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 668 publications over 30 distinct years, with a maximum of 62 publications in 2010

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

cardiovascular epidemiology
genetics studies
high blood pressure
risk prediction
Contact for Mentoring:

801 Massachusetts Ave Crosstown Center
Boston MA 02118
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