Vasan S. Ramachandran, MD
Professor
Boston University School of Medicine
Dept of Medicine
Preventive Medicine & Epidemiology Section

DM, All India Institute of Medical Sciences
MBBS, All India Institute of Medical Sciences
MD, All India Institute of Medical Sciences



For the last 18 years, I have focused my research on 4 inter-related areas. Briefly, these areas include:

a. Clinical and genetic epidemiology of congestive heart failure (CHF), including identifying risk factors for the disease, characterizing the subgroups with diastolic heart failure, asymptomatic LV systolic and diastolic dysfunction, and evaluating the role of LV remodeling; characterizing the genetic and clinical epidemiology of CHF and its subsets.

b. Clinical and genetic epidemiology of population-based vascular testing and echocardiography, including identifying biological, environmental, and genetic determinants (correlates) of cardiac structure and function; normative standards; detailed assessment of biomarkers of the process of left ventricular (LV) remodeling, including but not limited to role of natriuretic peptides, insulin resistance, cardiac extracellular matrix markers, oxidative stress, inflammation, growth factors; heritability of echocardiographic measurements, and genetic linkage; genes involved in LV remodeling, left atrial and aortic structure identified via genome-wide association Studies (GWAS) and gene-environment interactions; brachial artery endothelial function, its correlates, and tonometric assessment of large artery function.

c. Clinical and genetic epidemiology of cardiovascular risk factors, including high blood pressure, including characterizing the lifetime risk, rates of progression and risks associated with various degrees of elevation of CVD risk factors; large artery stiffness and function and role in systolic hypertension in the elderly; genetics of hypertension and large artery function.

d. Clinical and genetic epidemiology of exercise test responses in asymptomatic individuals and prognostic information; relations to endothelial and vascular function.

Section Chief
Boston University School of Medicine
Medicine
Preventive Medicine & Epidemiology Section

Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences


Co-Director, Echocardiography/Vascular Laboratory
Framingham Heart Study




Multidisciplinary Training Program in Cardiovascular Epidemiology
04/01/2016 - 03/31/2018 (PI)
NIH/National Heart, Lung, and Blood Institute
3T32HL125232-01A1S1

Framingham Heart Study
09/25/2015 - 03/31/2018 (PI)
NIH/National Heart, Lung, and Blood Institute

Framingham Heart Study
05/07/2015 - 03/31/2018 (PI)
NIH/National Heart, Lung, and Blood Institute

Lipid Biomarkers for Diabetic Heart Disease
04/15/2012 - 02/28/2018 (PI)
Washington University NIH
4P20HL113444-05

Cardiac Microstructure and heart failure risk in the Community
04/01/2016 - 01/31/2018 (PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL131532-02

Molecular and Genetic Epidimiology of Lipoprotein (A)-Mediated Calcific Aortic Valve Disease
01/01/2017 - 12/31/2017 (PI)
McGill University Health Center NIH NHLBI
1R01HL128550-01A1

Cardiovascular Genome Phenome Study
01/01/2014 - 11/30/2017 (PI)
American Heart Association

Vascular Stiffness as a Precursor of Hypertension in a Middle-aged Cohort
08/01/2015 - 06/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
5R01HL126136-02

Consortium to Study the Genetics of Longevity
06/01/2015 - 06/30/2017 (Co-PI)
PI: Sudha Seshadri, MD
Sutter Bay Hospitals dba California Pacific Medical Center NIH NIA
5U19AG023122-10

Integrating Lipid Genotypes and Phenotypes in iPS Delivered Hepatocytes/Adipocytes
07/05/2011 - 06/30/2017 (PI)
Massachusetts General Hospital NIH NHLBI
5U01HL107440-05

Showing 10 of 36 results. Show All Results

Population-Based Reference Ranges for Estradiol and Estrone in Men
04/07/2012 - 07/31/2012 (Activity-level PI)
PI: Shalender Bhasin, MBBS
NIH-NIDDK
1R01 DK092938-01A1



Yr Title Project-Sub Proj Pubs
2017 Cardiometabolic Outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS) 1R01HL136266-01
2017 Multidisciplinary Training Program in Cardiovascular Epidemiology 5T32HL125232-02
2017 Multidisciplinary Training Program in Cardiovascular Epidemiology 3T32HL125232-01A1S1
2017 Comprehensive Metabolic Profiling of Exercise to Predict Cardiometabolic Risk 5R01HL131029-02 4
2017 Clinical, genetic and cardiometabolic risk correlates of the gut microbiome 5R01HL131015-02
2016 Proteomic Pathway Discovery in Cardiovascular Disease 1R01HL132320-01
2016 Multidisciplinary Training Program in Cardiovascular Epidemiology 1T32HL125232-01A1
2016 IGF::OT::IGF FRAMINGHAM HEART STUDY (FHS) - TASK ORDER 01 268201500001I-2-26800001-1
2016 Clinical, genetic and cardiometabolic risk correlates of the gut microbiome 1R01HL131015-01
2016 Comprehensive Metabolic Profiling of Exercise to Predict Cardiometabolic Risk 1R01HL131029-01 4
Showing 10 of 63 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Jensen MK, Jensen RA, Mukamal KJ, Guo X, Yao J, Sun Q, Cornelis M, Liu Y, Chen MH, Kizer JR, Djoussé L, Siscovick DS, Psaty BM, Zmuda JM, Rotter JI, Garcia M, Harris T, Chen I, Goodarzi MO, Nalls MA, Keller M, Arnold AM, Newman AB, Hoogeveen RC, Rexrode KM, Rimm EB, Hu FB, Ramachandran VS, Katz R, Pankow JS, Ix JH. Detection of genetic loci associated with plasma fetuin-A: a meta-analysis of genome-wide association studies from the CHARGE Consortium. Hum Mol Genet. 2017 Jun 01; 26(11):2156-2163. PMID: 28379451.
  2. Tan ZS, Spartano NL, Beiser AS, DeCarli C, Auerbach SH, Vasan RS, Seshadri S. Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study. J Gerontol A Biol Sci Med Sci. 2017 Jun 01; 72(6):789-795.View Related Profiles. PMID: 27422439; DOI: 10.1093/gerona/glw130;.
  3. Niiranen TJ, Lyass A, Larson MG, Hamburg NM, Benjamin EJ, Mitchell GF, Vasan RS. Prevalence, Correlates, and Prognosis of Healthy Vascular Aging in a Western Community-Dwelling Cohort: The Framingham Heart Study. Hypertension. 2017 Aug; 70(2):267-274.View Related Profiles. PMID: 28559398; DOI: 10.1161/HYPERTENSIONAHA.117.09026;.
  4. Tragante V, Gho JMIH, Felix JF, Vasan RS, Smith NL, Voight BF, Palmer C, van der Harst P, Moore JH, Asselbergs FW. Gene Set Enrichment Analyses: lessons learned from the heart failure phenotype. BioData Min. 2017; 10:18. PMID: 28559929; DOI: 10.1186/s13040-017-0137-5;.
  5. Niiranen TJ, McCabe EL, Larson MG, Henglin M, Lakdawala NK, Vasan RS, Cheng S. Heritability and risks associated with early onset hypertension: multigenerational, prospective analysis in the Framingham Heart Study. BMJ. 2017 May 12; 357:j1949.View Related Profiles. PMID: 28500036.
  6. Maillard P, Mitchell GF, Himali JJ, Beiser A, Fletcher E, Tsao CW, Pase MP, Satizabal CL, Vasan RS, Seshadri S, DeCarli C. Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury. Stroke. 2017 Jun; 48(6):1567-1573.View Related Profiles. PMID: 28473633; DOI: 10.1161/STROKEAHA.116.016321;.
  7. Pase MP, Himali JJ, Beiser AS, Aparicio HJ, Satizabal CL, Vasan RS, Seshadri S, Jacques PF. Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study. Stroke. 2017 May; 48(5):1139-1146.View Related Profiles. PMID: 28428346; DOI: 10.1161/STROKEAHA.116.016027;.
  8. Freiberg MS, Chang CH, Skanderson M, Patterson OV, DuVall SL, Brandt CA, So-Armah KA, Vasan RS, Oursler KA, Gottdiener J, Gottlieb S, Leaf D, Rodriguez-Barradas M, Tracy RP, Gibert CL, Rimland D, Bedimo RJ, Brown ST, Goetz MB, Warner A, Crothers K, Tindle HA, Alcorn C, Bachmann JM, Justice AC, Butt AA. Association Between HIV Infection and the Risk of Heart Failure With Reduced Ejection Fraction and Preserved Ejection Fraction in the Antiretroviral Therapy Era: Results From the Veterans Aging Cohort Study. JAMA Cardiol. 2017 May 01; 2(5):536-546. PMID: 28384660; DOI: 10.1001/jamacardio.2017.0264;.
  9. Ho JE, McCabe EL, Wang TJ, Larson MG, Levy D, Tsao C, Aragam J, Mitchell GF, Benjamin EJ, Vasan RS, Cheng S. Cardiometabolic Traits and Systolic Mechanics in the Community. Circ Heart Fail. 2017 May; 10(5).View Related Profiles. PMID: 28495953.
  10. Niiranen TJ, McCabe EL, Larson MG, Henglin M, Lakdawala NK, Vasan RS, Cheng S. Risk for hypertension crosses generations in the community: a multi-generational cohort study. Eur Heart J. 2017 Apr 18.View Related Profiles. PMID: 28430902; DOI: 10.1093/eurheartj/ehx134;.
Showing 10 of 748 results. Show More