Richard H. Myers, PhD
Professor
Boston University School of Medicine
Dept of Neurology

PhD, Georgia State University
MA, Georgia State University
MEd, Georgia State University



My professional interests have focused upon the application of genetic research methods for the investigation of adult onset diseases with complex etiology (Parkinson’s disease, coronary heart disease, Alzheimer’s disease, pulmonary function, osteoarthritis, osteoporosis etc.). I have a long-standing interest in Huntington’s disease and have participated in a wide range of research investigations for this disease. I have been a member of the New England Huntington’s disease "Center Without Walls" since its inception in 1980. My HD studies may best be characterized as ‘Neurobiological Studies’ in that they include studies into the mechanisms of disease expression, including complex genetic modifier studies and a series of neuropathological studies of effects of disease expression in the brain. Additional interests are in the ethical issues influencing utilization of genetic test procedures.
I have been involved in a number of studies in positional cloning. I participated in the cloning of the gene for Huntington’s disease in 1993. I initiated the genome scan project in the Framingham Study, and a genome scan in Parkinson’s disease. My Parkinson’s disease genetic linkage study, known as the "GenePD" study, involves an international collaboration of twenty clinical centers in Parkinson’s disease. The study is seeking genetic loci involved in risk for PD. Since 1993 I have participated in genetic linkage studies for hypertension (the HyperGEN study, one of the NHLBI Family Blood Pressure Program Project studies), and the genome scan in the NHLBI Family Heart Study.

Director of Genome Science Institute
Boston University School of Medicine
Genome Science Institute


Aubrey Milunsky Chair in Human Genetics
Boston University School of Medicine
Medicine
Biomedical Genetics Section

Professor
Boston University School of Medicine
Medicine
Biomedical Genetics Section

Professor
Boston University School of Public Health
Environmental Health


Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences


Boston Medical Center


Member
Boston University
Bioinformatics Graduate Program




Functional analysis of Disease associated risk alleles in sporadic Parkinson's disease
09/23/2014 - 06/30/2018 (PI)
Whitehead Institute for Biomedical Resea NIH NINDS
5R01NS088538-03

Cyclin G-associated kinase as a novel target for Parkinson's disease
01/01/2017 - 12/31/2017 (PI)
Ellison Foundation

Probing the Dark Matter of the Genome in the NHLBI Family Heart Study
07/01/2016 - 06/30/2017 (PI)
Washington University NIH NHLBI
4R01HL117078-04

Epigenetic Markers in Huntington's Disease Brain
07/01/2011 - 04/30/2017 (PI)
NIH/National Institute of Neurological D
3R01NS073947-05S1

Probing the Dark Matter of the Genome in the NHLBI Family Heart Study
07/22/2013 - 06/30/2016 (PI)
Washington University NIH NHLBI
5R01HL117078-03

Epigenetic Markers of Huntington Disease Brain
07/01/2011 - 04/30/2016 (PI)
NIH/National Institute of Neurological Disorders & Stroke
1 R01 NS073947 01

Characterization of the role of cyclin G-associated kinase in Parkinson disease
09/01/2011 - 04/30/2015 (PI)
NIH/National Institute of Neurological D
5R01NS076843-03

Genomic Scan for Atherosclerosis Pathway Genes in African Americans from FHS Scan
05/15/2008 - 04/30/2013 (PI)
Washington University NIH NHLBI
5R01HL088215-04

Identifying Susceptibility Genes for Metabolic Syndrome
01/29/2007 - 12/31/2011 (PI)
Regents of the University of Minnesota NIH NIDDK
5R01DK068320-03

Mapping Adiposity QTLs in the NHLBI Family Heart Study
09/20/2004 - 06/30/2009 (PI)
Washington University, St Louis NIH NIDDK

Showing 10 of 12 results. Show All Results



Yr Title Project-Sub Proj Pubs
2016 An iPSC based platform for functionally assessing genetic and environmental risk 5R01NS088538-03 7
2015 An iPSC based platform for functionally assessing genetic and environmental risk 5R01NS088538-02 7
2015 Epigenetic Markers in Huntington's disease Brain 5R01NS073947-05 13
2015 Epigenetic Markers in Huntington's disease Brain 3R01NS073947-05S1 13
2014 An iPSC based platform for functionally assessing genetic and environmental risk 1R01NS088538-01 7
2014 Epigenetic Markers in Huntington's disease Brain 5R01NS073947-04 13
2013 Characterization of the role of cyclin G-associated kinase in Parkinson disease 5R01NS076843-03 6
2013 Epigenetic Markers in Huntington's disease Brain 5R01NS073947-03 13
2012 Characterization of the role of cyclin G-associated kinase in Parkinson disease 5R01NS076843-02 6
2012 Epigenetic Markers in Huntington's disease Brain 5R01NS073947-02 13
Showing 10 of 32 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Chao MJ, Gillis T, Atwal RS, Mysore JS, Arjomand J, Harold D, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF, Lee JM. Haplotype-based stratification of Huntington''s disease. Eur J Hum Genet. 2017 Aug 23. PMID: 28832564.
  2. Neueder A, Landles C, Ghosh R, Howland D, Myers RH, Faull RLM, Tabrizi SJ, Bates GP. The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington''s disease patients. Sci Rep. 2017 May 02; 7(1):1307. PMID: 28465506.
  3. Choi SH, Labadorf AT, Myers RH, Lunetta KL, Dupuis J, DeStefano AL. Evaluation of logistic regression models and effect of covariates for case-control study in RNA-Seq analysis. BMC Bioinformatics. 2017 Feb 06; 18(1):91.View Related Profiles. PMID: 28166718; DOI: 10.1186/s12859-017-1498-y;.
  4. Wake C, Labadorf A, Dumitriu A, Hoss AG, Bregu J, Albrecht KH, DeStefano AL, Myers RH. Novel microRNA discovery using small RNA sequencing in post-mortem human brain. BMC Genomics. 2016 Oct 04; 17(1):776.View Related Profiles. PMID: 27716130.
  5. Trinh J, Gustavsson EK, Vilariño-Güell C, Bortnick S, Latourelle J, McKenzie MB, Tu CS, Nosova E, Khinda J, Milnerwood A, Lesage S, Brice A, Tazir M, Aasly JO, Parkkinen L, Haytural H, Foroud T, Myers RH, Sassi SB, Hentati E, Nabli F, Farhat E, Amouri R, Hentati F, Farrer MJ. DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study. Lancet Neurol. 2016 Nov; 15(12):1248-1256.View Related Profiles. PMID: 27692902; DOI: 10.1016/S1474-4422(16)30203-4;.
  6. Nielson CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S, Jakobsdottir J, Wassel C, Register TC, Oei L, Alonso N, Oei EH, Parimi N, Samelson EJ, Nalls MA, Zmuda J, Lang T, Bouxsein M, Latourelle J, Claussnitzer M, Siggeirsdottir K, Srikanth P, Lorentzen E, Vandenput L, Langefeld C, Raffield L, Terry G, Cox AJ, Allison MA, Criqui MH, Bowden D, Ikram MA, Mellström D, Karlsson MK, Carr J, Budoff M, Phillips C, Cupples LA, Chou WC, Myers RH, Ralston SH, Gautvik KM, Cawthon PM, Cummings S, Karasik D, Rivadeneira F, Gudnason V, Orwoll ES, Harris TB, Ohlsson C, Kiel DP, Hsu YH. Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2. J Bone Miner Res. 2016 Dec; 31(12):2085-2097.View Related Profiles. PMID: 27476799; DOI: 10.1002/jbmr.2913;.
  7. Nagle MW, Latourelle JC, Labadorf A, Dumitriu A, Hadzi TC, Beach TG, Myers RH. The 4p16.3 Parkinson Disease Risk Locus Is Associated with GAK Expression and Genes Involved with the Synaptic Vesicle Membrane. PLoS One. 2016; 11(8):e0160925.View Related Profiles. PMID: 27508417; PMCID: PMC4980018; DOI: 10.1371/journal.pone.0160925;.
  8. Labadorf A, Hoss AG, Lagomarsino V, Latourelle JC, Hadzi TC, Bregu J, MacDonald ME, Gusella JF, Chen JF, Akbarian S, Weng Z, Myers RH. Correction: RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression. PLoS One. 2016; 11(7):e0160295.View Related Profiles. PMID: 27454300; DOI: 10.1371/journal.pone.0160295;.
  9. Soldner F, Stelzer Y, Shivalila CS, Abraham BJ, Latourelle JC, Barrasa MI, Goldmann J, Myers RH, Young RA, Jaenisch R. Parkinson-associated risk variant in distal enhancer of a-synuclein modulates target gene expression. Nature. 2016 May 5; 533(7601):95-9.View Related Profiles. PMID: 27096366; DOI: 10.1038/nature17939;.
  10. Hoss AG, Labadorf A, Beach TG, Latourelle JC, Myers RH. microRNA Profiles in Parkinson's Disease Prefrontal Cortex. Front Aging Neurosci. 2016; 8:36.View Related Profiles. PMID: 26973511; PMCID: PMC4772525; DOI: 10.3389/fnagi.2016.00036;.
Showing 10 of 284 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 280 publications over 37 distinct years, with a maximum of 15 publications in 2002

YearPublications
19801
19824
19832
19844
19855
19862
19877
19883
198912
19904
19917
199210
199310
19945
19955
19966
19978
199811
199910
200012
200113
200215
200313
20047
20058
200614
200710
200811
20098
20105
20115
201213
20133
20145
20159
201610
20173
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

coronary heart disease
genetic testing
Huntington's disease
Neurogenetics
Parkinson's disease
risk factors
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75 E. Newton St Evans Building
Boston MA 02118
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