Keywords
Last Name

Richard H. Myers, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentNeurology
Address75 E. Newton St Evans Building
Boston MA 02118
Phone(617) 638-5376
ORCID ORCID Icon0000-0002-8365-2674
Other Positions
TitleDirector of Genome Science Institute
InstitutionBoston University School of Medicine
DepartmentGenome Science Institute

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionBiomedical Genetics

TitleProfessor
InstitutionBoston University School of Public Health
DepartmentEnvironmental Health

TitleMentor for Graduate Medical Students
InstitutionBoston University School of Medicine, Graduate Medical Sciences

InstitutionBoston Medical Center

TitleMember
InstitutionBoston University
DepartmentBioinformatics Graduate Program

 Research Expertise & Professional Interests
My professional interests have focused upon the application of genetic research methods for the investigation of adult onset diseases with complex etiology (Parkinson’s disease, coronary heart disease, Alzheimer’s disease, pulmonary function, osteoarthritis, osteoporosis etc.). I have a long-standing interest in Huntington’s disease and have participated in a wide range of research investigations for this disease. I have been a member of the New England Huntington’s disease "Center Without Walls" since its inception in 1980. My HD studies may best be characterized as ‘Neurobiological Studies’ in that they include studies into the mechanisms of disease expression, including complex genetic modifier studies and a series of neuropathological studies of effects of disease expression in the brain. Additional interests are in the ethical issues influencing utilization of genetic test procedures.
I have been involved in a number of studies in positional cloning. I participated in the cloning of the gene for Huntington’s disease in 1993. I initiated the genome scan project in the Framingham Study, and a genome scan in Parkinson’s disease. My Parkinson’s disease genetic linkage study, known as the "GenePD" study, involves an international collaboration of twenty clinical centers in Parkinson’s disease. The study is seeking genetic loci involved in risk for PD. Since 1993 I have participated in genetic linkage studies for hypertension (the HyperGEN study, one of the NHLBI Family Blood Pressure Program Project studies), and the genome scan in the NHLBI Family Heart Study.

 Self-Described Keywords
  • coronary heart disease
  • genetic testing
  • Huntington's disease
  • Neurogenetics
  • Parkinson's disease
  • risk factors
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson''s disease. Nat Genet. 2014 Sep; 46(9):989-93.
    View in: PubMed
  2. Hoss AG, Kartha VK, Dong X, Latourelle JC, Dumitriu A, Hadzi TC, Macdonald ME, Gusella JF, Akbarian S, Chen JF, Weng Z, Myers RH. MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington''s Disease Pathogenesis. PLoS Genet. 2014 Feb; 10(2):e1004188.
    View in: PubMed
  3. McCusker EA, Myers RH. Feasibility of Huntington disease trials in the disease prodrome. Neurology. 2014 Mar 11; 82(10):824-5.
    View in: PubMed
  4. Hendricks AE, Dupuis J, Logue MW, Myers RH, Lunetta KL. Correction for multiple testing in a gene region. Eur J Hum Genet. 2014 Mar; 22(3):414-8.
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  5. Pichler I, Del Greco M F, Gögele M, Lill CM, Bertram L, Do CB, Eriksson N, Foroud T, Myers RH. Serum iron levels and the risk of Parkinson disease: a mendelian randomization study. PLoS Med. 2013; 10(6):e1001462.
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  6. Ramos EM, Latourelle JC, Gillis T, Mysore JS, Squitieri F, Di Pardo A, Di Donato S, Gellera C, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Gusella JF, Lee JM, Alonso I, Sequeiros J, Myers RH, Macdonald ME. Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington''s disease motor onset. Neurogenetics. 2013 Nov; 14(3-4):173-9.
    View in: PubMed
  7. Shulha HP, Crisci JL, Reshetov D, Tushir JS, Cheung I, Bharadwaj R, Chou HJ, Houston IB, Peter CJ, Mitchell AC, Yao WD, Myers RH, Chen JF, Preuss TM, Rogaev EI, Jensen JD, Weng Z, Akbarian S. Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol. 2012; 10(11):e1001427.
    View in: PubMed
  8. Latourelle JC, Dumitriu A, Hadzi TC, Beach TG, Myers RH. Evaluation of Parkinson disease risk variants as expression-QTLs. PLoS One. 2012; 7(10):e46199.
    View in: PubMed
  9. Hadzi TC, Hendricks AE, Latourelle JC, Lunetta KL, Cupples LA, Gillis T, Mysore JS, Gusella JF, MacDonald ME, Myers RH, Vonsattel JP. Assessment of cortical and striatal involvement in 523 Huntington disease brains. Neurology. 2012 Oct 16; 79(16):1708-15.
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  10. Wilk JB, Shrine NR, Loehr LR, Zhao JH, Manichaikul A, Lopez LM, Smith AV, Heckbert SR, Smolonska J, Tang W, Loth DW, Curjuric I, Hui J, Cho MH, Latourelle JC, Henry AP, Aldrich M, Bakke P, Beaty TH, Bentley AR, Borecki IB, Brusselle GG, Burkart KM, Chen TH, Couper D, Crapo JD, Davies G, Dupuis J, Franceschini N, Gulsvik A, Hancock DB, Harris TB, Hofman A, Imboden M, James AL, Khaw KT, Lahousse L, Launer LJ, Litonjua A, Liu Y, Lohman KK, Lomas DA, Lumley T, Marciante KD, McArdle WL, Meibohm B, Morrison AC, Musk AW, Myers RH, North KE, Postma DS, Psaty BM, Rich SS, Rivadeneira F, Rochat T, Rotter JI, Artigas MS, Starr JM, Uitterlinden AG, Wareham NJ, Wijmenga C, Zanen P, Province MA, Silverman EK, Deary IJ, Palmer LJ, Cassano PA, Gudnason V, Barr RG, Loos RJ, Strachan DP, London SJ, Boezen HM, Probst-Hensch N, Gharib SA, Hall IP, O'Connor GT, Tobin MD, Stricker BH. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med. 2012 Oct 1; 186(7):622-32.
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  11. Ramos EM, Latourelle JC, Lee JH, Gillis T, Mysore JS, Squitieri F, Di Pardo A, Di Donato S, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Marder K, Gusella JF, Lee JM, Alonso I, Sequeiros J, Myers RH, Macdonald ME. Population stratification may bias analysis of PGC-1a as a modifier of age at Huntington disease motor onset. Hum Genet. 2012 Dec; 131(12):1833-40.
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  12. Lee JH, Lee JM, Ramos EM, Gillis T, Mysore JS, Kishikawa S, Hadzi T, Hendricks AE, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Gellera C, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Landwehrmeyer GB. TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease. Biochem Biophys Res Commun. 2012 Aug 3; 424(3):404-8.
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  13. Dumitriu A, Latourelle JC, Hadzi TC, Pankratz N, Garza D, Miller JP, Vance JM, Foroud T, Beach TG, Myers RH. Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation. PLoS Genet. 2012 Jun; 8(6):e1002794.
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  14. Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet. 2012; 8(3):e1002548.
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  15. Dumitriu A, Moser C, Hadzi TC, Williamson SL, Pacheco CD, Hendricks AE, Latourelle JC, Wilk JB, Destefano AL, Myers RH. Postmortem Interval Influences a-Synuclein Expression in Parkinson Disease Brain. Parkinsons Dis. 2012; 2012:614212.
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  16. Lee JM, Gillis T, Mysore JS, Ramos EM, Myers RH, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Griguoli A, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, MacDonald ME, Gusella JF. Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region. Am J Hum Genet. 2012 Mar 9; 90(3):434-44.
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  17. Pankratz N, Beecham GW, DeStefano AL, Dawson TM, Doheny KF, Factor SA, Hamza TH, Hung AY, Hyman BT, Ivinson AJ, Krainc D, Latourelle JC, Clark LN, Marder K, Martin ER, Mayeux R, Ross OA, Scherzer CR, Simon DK, Tanner C, Vance JM, Wszolek ZK, Zabetian CP, Myers RH, Payami H, Scott WK, Foroud T. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. Ann Neurol. 2012 Mar; 71(3):370-84.
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  18. Lee JM, Ramos EM, Lee JH, Gillis T, Mysore JS, Hayden MR, Warby SC, Morrison P, Nance M, Ross CA, Margolis RL, Squitieri F, Orobello S, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Paulsen JS. CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology. 2012 Mar 6; 78(10):690-5.
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  19. Sebastiani P, Solovieff N, Dewan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. Genetic signatures of exceptional longevity in humans. PLoS One. 2012; 7(1):e29848.
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  20. Pankratz N, Dumitriu A, Hetrick KN, Sun M, Latourelle JC, Wilk JB, Halter C, Doheny KF, Gusella JF, Nichols WC, Myers RH, Foroud T, DeStefano AL. Copy number variation in familial Parkinson disease. PLoS One. 2011; 6(8):e20988.
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  21. Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Retraction. Science. 2011 Jul 22; 333(6041):404.
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  22. Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, Urnov FD, Rebar EJ, Gregory PD, Zhang HS, Jaenisch R. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell. 2011 Jul 22; 146(2):318-31.
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  23. Latourelle JC, Hendricks AE, Pankratz N, Wilk JB, Halter C, Nichols WC, Gusella JF, Destefano AL, Myers RH, Foroud T. Genomewide linkage study of modifiers of LRRK2-related Parkinson's disease. Mov Disord. 2011 Sep; 26(11):2039-44.
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  24. Dumitriu A, Pacheco CD, Wilk JB, Strathearn KE, Latourelle JC, Goldwurm S, Pezzoli G, Rochet JC, Lindquist S, Myers RH. Cyclin-G-associated kinase modifies a-synuclein expression levels and toxicity in Parkinson''s disease: results from the GenePD Study. Hum Mol Genet. 2011 Apr 15; 20(8):1478-87.
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  25. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ, Segrè AV, Estrada K, Liang L, Nemesh J, Park JH, Gustafsson S, Kilpeläinen TO, Yang J, Bouatia-Naji N, Esko T, Feitosa MF, Kutalik Z, Mangino M, Raychaudhuri S, Scherag A, Smith AV, Welch R, Zhao JH, Aben KK, Absher DM, Amin N, Dixon AL, Fisher E, Glazer NL, Goddard ME, Heard-Costa NL, Hoesel V, Hottenga JJ, Johansson A, Johnson T, Ketkar S, Lamina C, Li S, Moffatt MF, Myers RH, Narisu N, Perry JR, Peters MJ, Preuss M, Ripatti S, Rivadeneira F, Sandholt C, Scott LJ, Timpson NJ, Tyrer JP, van Wingerden S, Watanabe RM, White CC, Wiklund F, Barlassina C, Chasman DI, Cooper MN, Jansson JO, Lawrence RW, Pellikka N, Prokopenko I, Shi J, Thiering E, Alavere H, Alibrandi MT, Almgren P, Arnold AM, Aspelund T, Atwood LD, Balkau B, Balmforth AJ, Bennett AJ, Ben-Shlomo Y, Bergman RN, Bergmann S, Biebermann H, Blakemore AI, Boes T, Bonnycastle LL, Bornstein SR, Brown MJ, Buchanan TA, Busonero F, Campbell H, Cappuccio FP, Cavalcanti-Proença C, Chen YD, Chen CM, Chines PS, Clarke R, Coin L, Connell J, Day IN, den Heijer M, Duan J, Ebrahim S, Elliott P, Elosua R, Eiriksdottir G, Erdos MR, Eriksson JG, Facheris MF, Felix SB, Fischer-Posovszky P, Folsom AR, Friedrich N, Freimer NB, Fu M, Gaget S, Gejman PV, Geus EJ, Gieger C, Gjesing AP, Goel A, Goyette P, Grallert H, Grässler J, Greenawalt DM, Groves CJ, Gudnason V, Guiducci C, Hartikainen AL, Hassanali N, Hall AS, Havulinna AS, Hayward C, Heath AC, Hengstenberg C, Hicks AA, Hinney A, Hofman A, Homuth G, Hui J, Igl W, Iribarren C, Isomaa B, Jacobs KB, Jarick I, Jewell E, John U, Jørgensen T, Jousilahti P, Jula A, Kaakinen M, Kajantie E, Kaplan LM, Kathiresan S, Kettunen J, Kinnunen L, Knowles JW, Kolcic I, König IR, Koskinen S, Kovacs P, Kuusisto J, Kraft P, Kvaløy K, Laitinen J, Lantieri O, Lanzani C, Launer LJ, Lecoeur C, Lehtimäki T, Lettre G, Liu J, Lokki ML, Lorentzon M, Luben RN, Ludwig B. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010 Nov; 42(11):937-48.
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  26. Lanoue AC, Dumitriu A, Myers RH, Soghomonian JJ. Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease. Exp Neurol. 2010 Nov; 226(1):207-17.
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  27. Latourelle JC, Dybdahl M, Destefano AL, Myers RH, Lash TL. Estrogen-related and other disease diagnoses preceding Parkinson's disease. Clin Epidemiol. 2010; 2:153-70.
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  28. Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Genetic signatures of exceptional longevity in humans. Science. 2010 Jul 1; 2010.
    View in: PubMed
  29. Latourelle JC, Dybdahl M, Destefano AL, Myers RH, Lash TL. Risk of Parkinson's disease after tamoxifen treatment. BMC Neurol. 2010; 10:23.
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  30. Latourelle JC, Pankratz N, Dumitriu A, Wilk JB, Goldwurm S, Pezzoli G, Mariani CB, DeStefano AL, Halter C, Gusella JF, Nichols WC, Myers RH, Foroud T. Genomewide association study for onset age in Parkinson disease. BMC Med Genet. 2009; 10:98.
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  31. Hendricks AE, Latourelle JC, Lunetta KL, Cupples LA, Wheeler V, MacDonald ME, Gusella JF, Myers RH. Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG). Am J Med Genet A. 2009 Jul; 149A(7):1375-81.
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  32. Feitosa MF, North KE, Myers RH, Pankow JS, Borecki IB. Evidence for three novel QTLs for adiposity on chromosome 2 with epistatic interactions: the NHLBI Family Heart Study. Obesity (Silver Spring). 2009 Dec; 17(12):2190-5.
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  33. Swami M, Hendricks AE, Gillis T, Massood T, Mysore J, Myers RH, Wheeler VC. Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset. Hum Mol Genet. 2009 Aug 15; 18(16):3039-47.
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  34. Laramie JM, Wilk JB, Williamson SL, Nagle MW, Latourelle JC, Tobin JE, Province MA, Borecki IB, Myers RH. Multiple genes influence BMI on chromosome 7q31-34: the NHLBI Family Heart Study. Obesity (Silver Spring). 2009 Dec; 17(12):2182-9.
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  35. Wilk JB, Chen TH, Gottlieb DJ, Walter RE, Nagle MW, Brandler BJ, Myers RH, Borecki IB, Silverman EK, Weiss ST, O'Connor GT. A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet. 2009 Mar; 5(3):e1000429.
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  36. Franceschini N, North KE, Arnett D, Pankow JS, Chung JH, Baird L, Leppert MF, Eckfeldt JH, Boerwinkle E, Gu CC, Lewis CE, Myers RH, Turner ST, Weder A, Kao WH, Mosley TH, Chakravarti A, Kramer H, Zhang J, Hunt SC. The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study. Am J Hypertens. 2009 May; 22(5):552-8.
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  37. Ma D, Feitosa MF, Wilk JB, Laramie JM, Yu K, Leiendecker-Foster C, Myers RH, Province MA, Borecki IB. Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study. Hypertension. 2009 Mar; 53(3):473-9.
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  38. Wu J, Pankow JS, Tracy RP, North KE, Myers RH, Feitosa ME, Province MA, Borecki IB. A QTL on 12q influencing an inflammation marker and obesity in white women: the NHLBI Family Heart Study. Obesity (Silver Spring). 2009 Mar; 17(3):525-31.
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  39. Shi G, Gu CC, Kraja AT, Arnett DK, Myers RH, Pankow JS, Hunt SC, Rao DC. Genetic effect on blood pressure is modulated by age: the Hypertension Genetic Epidemiology Network Study. Hypertension. 2009 Jan; 53(1):35-41.
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  40. Pankratz N, Wilk JB, Latourelle JC, DeStefano AL, Halter C, Pugh EW, Doheny KF, Gusella JF, Nichols WC, Foroud T, Myers RH. Genomewide association study for susceptibility genes contributing to familial Parkinson disease. Hum Genet. 2009 Jan; 124(6):593-605.
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  41. Latourelle JC, Sun M, Lew MF, Suchowersky O, Klein C, Golbe LI, Mark MH, Growdon JH, Wooten GF, Watts RL, Guttman M, Racette BA, Perlmutter JS, Ahmed A, Shill HA, Singer C, Goldwurm S, Pezzoli G, Zini M, Saint-Hilaire MH, Hendricks AE, Williamson S, Nagle MW, Wilk JB, Massood T, Huskey KW, Laramie JM, DeStefano AL, Baker KB, Itin I, Litvan I, Nicholson G, Corbett A, Nance M, Drasby E, Isaacson S, Burn DJ, Chinnery PF, Pramstaller PP, Al-hinti J, Moller AT, Ostergaard K, Sherman SJ, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH. The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study. BMC Med. 2008; 6:32.
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  42. Feitosa MF, Myers RH, Pankow JS, Province MA, Borecki IB. LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion. Atherosclerosis. 2009 May; 204(1):171-7.
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  43. McNicoll CF, Latourelle JC, MacDonald ME, Lew MF, Suchowersky O, Klein C, Golbe LI, Mark MH, Growdon JH, Wooten GF, Watts RL, Guttman M, Racette BA, Perlmutter JS, Ahmed A, Shill HA, Singer C, Saint-Hilaire MH, Massood T, Huskey KW, DeStefano AL, Gillis T, Mysore J, Goldwurm S, Pezzoli G, Baker KB, Itin I, Litvan I, Nicholson G, Corbett A, Nance M, Drasby E, Isaacson S, Burn DJ, Chinnery PF, Pramstaller PP, Al-Hinti J, Moller AT, Ostergaard K, Sherman SJ, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH. Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study. Mov Disord. 2008 Aug 15; 23(11):1596-601.
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  44. DeStefano AL, Latourelle J, Lew MF, Suchowersky O, Klein C, Golbe LI, Mark MH, Growdon JH, Wooten GF, Watts R, Guttman M, Racette BA, Perlmutter JS, Marlor L, Shill HA, Singer C, Goldwurm S, Pezzoli G, Saint-Hilaire MH, Hendricks AE, Gower A, Williamson S, Nagle MW, Wilk JB, Massood T, Huskey KW, Baker KB, Itin I, Litvan I, Nicholson G, Corbett A, Nance M, Drasby E, Isaacson S, Burn DJ, Chinnery PF, Pramstaller PP, Al-Hinti J, Moller AT, Ostergaard K, Sherman SJ, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH. Replication of association between ELAVL4 and Parkinson disease: the GenePD study. Hum Genet. 2008 Aug; 124(1):95-9.
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  45. Tobin JE, Latourelle JC, Lew MF, Klein C, Suchowersky O, Shill HA, Golbe LI, Mark MH, Growdon JH, Wooten GF, Racette BA, Perlmutter JS, Watts R, Guttman M, Baker KB, Goldwurm S, Pezzoli G, Singer C, Saint-Hilaire MH, Hendricks AE, Williamson S, Nagle MW, Wilk JB, Massood T, Laramie JM, DeStefano AL, Litvan I, Nicholson G, Corbett A, Isaacson S, Burn DJ, Chinnery PF, Pramstaller PP, Sherman S, Al-hinti J, Drasby E, Nance M, Moller AT, Ostergaard K, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH. Haplotypes and gene expression implicate the MAPT region for Parkinson disease: the GenePD Study. Neurology. 2008 Jul 1; 71(1):28-34.
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  46. Laramie JM, Wilk JB, Williamson SL, Nagle MW, Latourelle JC, Tobin JE, Province MA, Borecki IB, Myers RH. Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. BMC Med Genet. 2008; 9:46.
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  47. Zhang Q, Lewis CE, Wagenknecht LE, Myers RH, Pankow JS, Hunt SC, North KE, Hixson JE, Jeffrey Carr J, Shimmin LC, Borecki I, Province MA. Genome-wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart Study. Genet Epidemiol. 2008 Apr; 32(3):264-72.
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  48. Wilk JB, Laramie JM, Latourelle JC, Williamson S, Nagle MW, Tobin JE, Foster CL, Eckfeldt JH, Province MA, Borecki IB, Myers RH. NYD-SP18 is associated with obesity in the NHLBI Family Heart Study. Int J Obes (Lond). 2008 Jun; 32(6):930-5.
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  49. Bielinski SJ, Pankow JS, Foster CL, Miller MB, Hopkins PN, Eckfeldt JH, Hixson J, Liu Y, Register T, Myers RH, Arnett DK. Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: the NHLBI Family Heart Study follow-up examination. Atherosclerosis. 2008 Jul; 199(1):172-8.
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  50. Bielinski SJ, Pankow JS, Miller MB, Hopkins PN, Eckfeldt JH, Hixson J, Liu Y, Register T, Myers RH, Arnett DK. Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow-up examination. Genes Immun. 2007 Dec; 8(8):684-90.
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  51. Dupré N, Rivière JB, Myers RH, Provencher P, Pourcher E, Emond F, Rouleau GA. LRRK2 is not a significant cause of Parkinson's disease in French-Canadians. Can J Neurol Sci. 2007 Aug; 34(3):333-5.
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  52. Wheeler VC, Persichetti F, McNeil SM, Mysore JS, Mysore SS, MacDonald ME, Myers RH, Gusella JF, Wexler NS. Factors associated with HD CAG repeat instability in Huntington disease. J Med Genet. 2007 Nov; 44(11):695-701.
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  53. Laramie JM, Wilk JB, DeStefano AL, Myers RH. HaploBuild: an algorithm to construct non-contiguous associated haplotypes in family based genetic studies. Bioinformatics. 2007 Aug 15; 23(16):2190-2.
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  54. Litvan I, Chesselet MF, Gasser T, Di Monte DA, Parker D, Hagg T, Hardy J, Jenner P, Myers RH, Price D, Hallett M, Langston WJ, Lang AE, Halliday G, Rocca W, Duyckaerts C, Dickson DW, Ben-Shlomo Y, Goetz CG, Melamed E. The etiopathogenesis of Parkinson disease and suggestions for future research. Part II. J Neuropathol Exp Neurol. 2007 May; 66(5):329-36.
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  55. Litvan I, Halliday G, Hallett M, Goetz CG, Rocca W, Duyckaerts C, Ben-Shlomo Y, Dickson DW, Lang AE, Chesselet MF, Langston WJ, Di Monte DA, Gasser T, Hagg T, Hardy J, Jenner P, Melamed E, Myers RH, Parker D, Price DL. The etiopathogenesis of Parkinson disease and suggestions for future research. Part I. J Neuropathol Exp Neurol. 2007 Apr; 66(4):251-7.
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  56. Greenwood TA, Libiger O, Kardia S, Hanis C, Morrison AC, Gu CC, Rice T, Miller M, Turner ST, Myers RH, Grove J, Hsiao CF, Weder AB, Schork NJ. Comprehensive linkage and linkage heterogeneity analysis of 4344 sibling pairs affected with hypertension from the Family Blood Pressure Program. Genet Epidemiol. 2007 Apr; 31(3):195-210.
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  57. Tobin JE, Cui J, Wilk JB, Latourelle JC, Laramie JM, McKee AC, Guttman M, Karamohamed S, DeStefano AL, Myers RH. Sepiapterin reductase expression is increased in Parkinson's disease brain tissue. Brain Res. 2007 Mar 30; 1139:42-7.
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  58. North KE, Franceschini N, Borecki IB, Gu CC, Heiss G, Province MA, Arnett DK, Lewis CE, Miller MB, Myers RH, Hunt SC, Freedman BI. Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN study. Diabetes. 2007 Jan; 56(1):137-42.
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  59. Wilk JB, Tobin JE, Suchowersky O, Shill HA, Klein C, Wooten GF, Lew MF, Mark MH, Guttman M, Watts RL, Singer C, Growdon JH, Latourelle JC, Saint-Hilaire MH, DeStefano AL, Prakash R, Williamson S, Berg CJ, Sun M, Goldwurm S, Pezzoli G, Racette BA, Perlmutter JS, Parsian A, Baker KB, Giroux ML, Litvan I, Pramstaller PP, Nicholson G, Burn DJ, Chinnery PF, Vieregge P, Slevin JT, Cambi F, MacDonald ME, Gusella JF, Myers RH, Golbe LI. Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: the GenePD Study. Neurology. 2006 Dec 26; 67(12):2206-10.
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  60. Andresen JM, Gayán J, Djoussé L, Roberts S, Brocklebank D, Cherny SS. The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset. Ann Hum Genet. 2007 May; 71(Pt 3):295-301.
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  61. Kraja AT, Borecki IB, North K, Tang W, Myers RH, Hopkins PN, Arnett D, Corbett J, Adelman A, Province MA. Longitudinal and age trends of metabolic syndrome and its risk factors: the Family Heart Study. Nutr Metab (Lond). 2006; 3:41.
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  62. Zeng W, Gillis T, Hakky M, Djoussé L, Myers RH, MacDonald ME, Gusella JF. Genetic analysis of the GRIK2 modifier effect in Huntington's disease. BMC Neurosci. 2006; 7:62.
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  63. Kishikawa S, Li JL, Gillis T, Hakky MM, Warby S, Hayden M, MacDonald ME, Myers RH, Gusella JF. Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease. Neurobiol Dis. 2006 Nov; 24(2):280-5.
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  64. Wilk JB, Myers RH, Pankow JS, Hunt SC, Leppert MF, Freedman BI, Province MA, Ellison RC. Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study. Ann Hum Genet. 2006 Sep; 70(Pt 5):566-73.
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  65. Li JL, Hayden MR, Warby SC, Durr A, Morrison PJ, Nance M, Ross CA, Margolis RL, Rosenblatt A, Squitieri F, Frati L, Gómez-Tortosa E, García CA, Suchowersky O, Klimek ML, Trent RJ, McCusker E, Novelletto A, Frontali M, Paulsen JS, Jones R, Ashizawa T, Lazzarini A, Wheeler VC, Prakash R, Xu G, Djoussé L, Mysore JS, Gillis T, Hakky M, Cupples LA, Saint-Hilaire MH, Cha JH, Hersch SM, Penney JB, Harrison MB, Perlman SL, Zanko A, Abramson RK, Lechich AJ, Duckett A, Marder K, Conneally PM, Gusella JF, MacDonald ME, Myers RH. Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study. BMC Med Genet. 2006; 7:71.
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  66. Avery CL, Freedman BI, Kraja AT, Borecki IB, Miller MB, Pankow JS, Arnett D, Lewis CE, Myers RH, Hunt SC, North KE. Genotype-by-sex interaction in the aetiology of type 2 diabetes mellitus: support for sex-specific quantitative trait loci in Hypertension Genetic Epidemiology Network participants. Diabetologia. 2006 Oct; 49(10):2329-36.
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  67. Sun M, Latourelle JC, Wooten GF, Lew MF, Klein C, Shill HA, Golbe LI, Mark MH, Racette BA, Perlmutter JS, Parsian A, Guttman M, Nicholson G, Xu G, Wilk JB, Saint-Hilaire MH, DeStefano AL, Prakash R, Williamson S, Suchowersky O, Labelle N, Growdon JH, Singer C, Watts RL, Goldwurm S, Pezzoli G, Baker KB, Pramstaller PP, Burn DJ, Chinnery PF, Sherman S, Vieregge P, Litvan I, Gillis T, MacDonald ME, Myers RH, Gusella JF. Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study. Arch Neurol. 2006 Jun; 63(6):826-32.
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  68. Myers RH. Considerations for genomewide association studies in Parkinson disease. Am J Hum Genet. 2006 Jun; 78(6):1081-2.
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  69. Lloret A, Dragileva E, Teed A, Espinola J, Fossale E, Gillis T, Lopez E, Myers RH, MacDonald ME, Wheeler VC. Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice. Hum Mol Genet. 2006 Jun 15; 15(12):2015-24.
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  70. Feitosa MF, Province MA, Heiss G, Arnett DK, Myers RH, Pankow JS, Hopkins PN, Borecki IB. Evidence of QTL on 15q21 for high-density lipoprotein cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study (NHLBI FHS). Atherosclerosis. 2007 Jan; 190(1):232-7.
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  71. Laramie JM, Wilk JB, Hunt SC, Ellison RC, Chakravarti A, Boerwinkle E, Myers RH. Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program. BMC Med Genet. 2006; 7:17.
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  72. An P, Freedman BI, Rich SS, Mandel SA, Arnett DK, Myers RH, Chen YD, Hunt SC, Rao DC. Quantitative trait loci on chromosome 8q24 for pancreatic beta-cell function and 7q11 for insulin sensitivity in obese nondiabetic white and black families: evidence from genome-wide linkage scans in the NHLBI Hypertension Genetic Epidemiology Network (HyperGEN) study. Diabetes. 2006 Feb; 55(2):551-8.
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  73. Karamohamed S, Latourelle JC, Racette BA, Perlmutter JS, Wooten GF, Lew M, Klein C, Shill H, Golbe LI, Mark MH, Guttman M, Nicholson G, Wilk JB, Saint-Hilaire M, DeStefano AL, Prakash R, Tobin S, Williamson J, Suchowersky O, Labell N, Growdon BN, Singer C, Watts R, Goldwurm S, Pezzoli G, Baker KB, Giroux ML, Pramstaller PP, Burn DJ, Chinnery P, Sherman S, Vieregge P, Litvan I, Gusella JF, Myers RH, Parsian A. BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study. Neurology. 2005 Dec 13; 65(11):1823-5.
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  74. Kraja AT, Hunt SC, Pankow JS, Myers RH, Heiss G, Lewis CE, Rao DC, Province MA. Quantitative trait loci for metabolic syndrome in the Hypertension Genetic Epidemiology Network study. Obes Res. 2005 Nov; 13(11):1885-90.
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  75. Karamohamed S, Golbe LI, Mark MH, Lazzarini AM, Suchowersky O, Labelle N, Guttman M, Currie LJ, Wooten GF, Stacy M, Saint-Hilaire M, Feldman RG, Liu J, Shoemaker CM, Wilk JB, DeStefano AL, Latourelle JC, Xu G, Watts R, Growdon J, Lew M, Waters C, Vieregge P, Pramstaller PP, Klein C, Racette BA, Perlmutter JS, Parsian A, Singer C, Montgomery E, Baker K, Gusella JF, Herbert A, Myers RH. Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study. Mov Disord. 2005 Sep; 20(9):1188-91.
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  76. Seong IS, Ivanova E, Lee JM, Choo YS, Fossale E, Anderson M, Gusella JF, Laramie JM, Myers RH, Lesort M, MacDonald ME. HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism. Hum Mol Genet. 2005 Oct 1; 14(19):2871-80.
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  77. Yu K, Zhang S, Borecki I, Kraja A, Xiong C, Myers R, Province M. A haplotype similarity based transmission/disequilibrium test under founder heterogeneity. Ann Hum Genet. 2005 Jul; 69(Pt 4):455-67.
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  78. Friedman JH, Trieschmann ME, Myers RH, Fernandez HH. Monozygotic twins discordant for Huntington disease after 7 years. Arch Neurol. 2005 Jun; 62(6):995-7.
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  79. Lin JP, Myers RH, Almasy L, Coon HH, Arnett DK, Hong Y, Hunt SC. Linkage of the cholesterol 7alpha-hydroxylase gene and low-density lipoprotein cholesterol conditional on apolipoprotein E association: the National Heart, Lung, and Blood Institute Family Heart Study. Chin Med J (Engl). 2005 Mar 5; 118(5):362-9.
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  80. Kraja AT, Hunt SC, Pankow JS, Myers RH, Heiss G, Lewis CE, Rao D, Province MA. An evaluation of the metabolic syndrome in the HyperGEN study. Nutr Metab (Lond). 2005 Jan 18; 2(1):2.
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  81. Djoussé L, Pankow JS, Arnett DK, Eckfeldt JH, Myers RH, Ellison RC. Apolipoprotein E polymorphism modifies the alcohol-HDL association observed in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr. 2004 Dec; 80(6):1639-44.
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  82. Avery CL, Freedman BI, Heiss G, Kraja A, Rice T, Arnett D, Miller MB, Pankow JS, Lewis CE, Myers RH, Hunt SC, Almasy L, North KE. Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study. Diabetes. 2004 Dec; 53(12):3307-12.
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  83. Wilk JB, Djousse L, Arnett DK, Hunt SC, Province MA, Heiss G, Myers RH. Genome-wide linkage analyses for age at diagnosis of hypertension and early-onset hypertension in the HyperGEN study. Am J Hypertens. 2004 Sep; 17(9):839-44.
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  84. Jiang Y, Wilk JB, Borecki I, Williamson S, DeStefano AL, Xu G, Liu J, Ellison RC, Province M, Myers RH. Common variants in the 5'' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet. 2004 Aug; 75(2):220-30.
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  85. Myers RH. Huntington's disease genetics. NeuroRx. 2004 Apr; 1(2):255-62.
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  86. Djoussé L, Knowlton B, Hayden MR, Almqvist EW, Brinkman RR, Ross CA, Margolis RL, Rosenblatt A, Durr A, Dode C, Morrison PJ, Novelletto A, Frontali M, Trent RJ, McCusker E, Gómez-Tortosa E, Mayo Cabrero D, Jones R, Zanko A, Nance M, Abramson RK, Suchowersky O, Paulsen JS, Harrison MB, Yang Q, Cupples LA, Mysore J, Gusella JF, MacDonald ME, Myers RH. Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16. Neurogenetics. 2004 Jun; 5(2):109-14.
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  87. Herrera VL, Didishvili T, Lopez LV, Myers RH, Ruiz-Opazo N. Genome-wide scan identifies novel QTLs for cholesterol and LDL levels in F2[Dahl RxS]-intercross rats. Circ Res. 2004 Mar 5; 94(4):446-52.
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  88. Karamohamed S, DeStefano AL, Wilk JB, Shoemaker CM, Golbe LI, Mark MH, Lazzarini AM, Suchowersky O, Labelle N, Guttman M, Currie LJ, Wooten GF, Stacy M, Saint-Hilaire M, Feldman RG, Sullivan KM, Xu G, Watts R, Growdon J, Lew M, Waters C, Vieregge P, Pramstaller PP, Klein C, Racette BA, Perlmutter JS, Parsian A, Singer C, Montgomery E, Baker K, Gusella JF, Fink SJ, Myers RH, Herbert A. A haplotype at the PARK3 locus influences onset age for Parkinson's disease: the GenePD study. Neurology. 2003 Dec 9; 61(11):1557-61.
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  89. Tang W, Miller MB, Rich SS, North KE, Pankow JS, Borecki IB, Myers RH, Hopkins PN, Leppert M, Arnett DK. Linkage analysis of a composite factor for the multiple metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. Diabetes. 2003 Nov; 52(11):2840-7.
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  90. Gagnon DR, Glickman ME, Myers RH, Cupples LA. The analysis of survival data with a non-susceptible fraction and dual censoring mechanisms. Stat Med. 2003 Oct 30; 22(20):3249-62.
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  91. Wilk JB, DeStefano AL, Joost O, Myers RH, Cupples LA, Slater K, Atwood LD, Heard-Costa NL, Herbert A, O'Connor GT, Gottlieb DJ. Linkage and association with pulmonary function measures on chromosome 6q27 in the Framingham Heart Study. Hum Mol Genet. 2003 Nov 1; 12(21):2745-51.
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  92. Li JL, Hayden MR, Almqvist EW, Brinkman RR, Durr A, Dodé C, Morrison PJ, Suchowersky O, Ross CA, Margolis RL, Rosenblatt A, Gómez-Tortosa E, Cabrero DM, Novelletto A, Frontali M, Nance M, Trent RJ, McCusker E, Jones R, Paulsen JS, Harrison M, Zanko A, Abramson RK, Russ AL, Knowlton B, Djoussé L, Mysore JS, Tariot S, Gusella MF, Wheeler VC, Atwood LD, Cupples LA, Saint-Hilaire M, Cha JH, Hersch SM, Koroshetz WJ, Gusella JF, MacDonald ME, Myers RH. A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study. Am J Hum Genet. 2003 Sep; 73(3):682-7.
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  93. Djoussé L, Knowlton B, Hayden M, Almqvist EW, Brinkman R, Ross C, Margolis R, Rosenblatt A, Durr A, Dode C, Morrison PJ, Novelletto A, Frontali M, Trent RJ, McCusker E, Gómez-Tortosa E, Mayo D, Jones R, Zanko A, Nance M, Abramson R, Suchowersky O, Paulsen J, Harrison M, Yang Q, Cupples LA, Gusella JF, MacDonald ME, Myers RH. Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease. Am J Med Genet A. 2003 Jun 15; 119A(3):279-82.
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  94. Wheelock VL, Tempkin T, Marder K, Nance M, Myers RH, Zhao H, Kayson E, Orme C, Shoulson I. Predictors of nursing home placement in Huntington disease. Neurology. 2003 Mar 25; 60(6):998-1001.
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  95. Panhuysen CI, Cupples LA, Wilson PW, Herbert AG, Myers RH, Meigs JB. A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study. Diabetologia. 2003 Apr; 46(4):579-87.
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  96. Wilk JB, DeStefano AL, Arnett DK, Rich SS, Djousse L, Crapo RO, Leppert MF, Province MA, Cupples LA, Gottlieb DJ, Myers RH. A genome-wide scan of pulmonary function measures in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Respir Crit Care Med. 2003 Jun 1; 167(11):1528-33.
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  97. Wu X, Cooper RS, Boerwinkle E, Turner ST, Hunt S, Myers R, Olshen RA, Curb D, Zhu X, Kan D, Luke A. Combined analysis of genomewide scans for adult height: results from the NHLBI Family Blood Pressure Program. Eur J Hum Genet. 2003 Mar; 11(3):271-4.
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  98. DeStefano AL, Gates GA, Heard-Costa N, Myers RH, Baldwin CT. Genomewide linkage analysis to presbycusis in the Framingham Heart Study. Arch Otolaryngol Head Neck Surg. 2003 Mar; 129(3):285-9.
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  99. Mukhopadhyay N, Finegold DN, Larson MG, Cupples LA, Myers RH, Weeks DE. A genome-wide scan for loci affecting normal adult height in the Framingham Heart Study. Hum Hered. 2003; 55(4):191-201.
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  100. Gasser T, Bressman S, Dürr A, Higgins J, Klockgether T, Myers RH. State of the art review: molecular diagnosis of inherited movement disorders. Movement Disorders Society task force on molecular diagnosis. Mov Disord. 2003 Jan; 18(1):3-18.
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  101. Van Laer L, DeStefano AL, Myers RH, Flothmann K, Thys S, Fransen E, Gates GA, Van Camp G, Baldwin CT. Is DFNA5 a susceptibility gene for age-related hearing impairment? Eur J Hum Genet. 2002 Dec; 10(12):883-6.
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  102. Djoussé L, Knowlton B, Cupples LA, Marder K, Shoulson I, Myers RH. Weight loss in early stage of Huntington's disease. Neurology. 2002 Nov 12; 59(9):1325-30.
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  103. Karasik D, Myers RH, Hannan MT, Gagnon D, McLean RR, Cupples LA, Kiel DP. Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysis. Osteoporos Int. 2002 Oct; 13(10):796-802.
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  104. Karasik D, Myers RH, Cupples LA, Hannan MT, Gagnon DR, Herbert A, Kiel DP. Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: the Framingham Study. J Bone Miner Res. 2002 Sep; 17(9):1718-27.
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  105. Coon H, Eckfeldt JH, Leppert MF, Myers RH, Arnett DK, Heiss G, Province MA, Hunt SC. A genome-wide screen reveals evidence for a locus on chromosome 11 influencing variation in LDL cholesterol in the NHLBI Family Heart Study. Hum Genet. 2002 Sep; 111(3):263-9.
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  106. Wilk JB, Myers RH, Zhang Y, Lewis CE, Atwood L, Hopkins PN, Ellison RC. Evidence for a gene influencing heart rate on chromosome 4 among hypertensives. Hum Genet. 2002 Aug; 111(2):207-13.
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  107. Coady SA, Jaquish CE, Fabsitz RR, Larson MG, Cupples LA, Myers RH. Genetic variability of adult body mass index: a longitudinal assessment in framingham families. Obes Res. 2002 Jul; 10(7):675-81.
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  108. Djoussé L, Myers RH, Province MA, Hunt SC, Eckfeldt JH, Evans G, Peacock JM, Ellison RC. Influence of apolipoprotein E, smoking, and alcohol intake on carotid atherosclerosis: National Heart, Lung, and Blood Institute Family Heart Study. Stroke. 2002 May; 33(5):1357-61.
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  109. Maher NE, Currie LJ, Lazzarini AM, Wilk JB, Taylor CA, Saint-Hilaire MH, Feldman RG, Golbe LI, Wooten GF, Myers RH. Segregation analysis of Parkinson disease revealing evidence for a major causative gene. Am J Med Genet. 2002 May 1; 109(3):191-7.
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  110. Demissie S, Cupples LA, Myers R, Aliabadi P, Levy D, Felson DT. Genome scan for quantity of hand osteoarthritis: the Framingham Study. Arthritis Rheum. 2002 Apr; 46(4):946-52.
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  111. DeStefano AL, Lew MF, Golbe LI, Mark MH, Lazzarini AM, Guttman M, Montgomery E, Waters CH, Singer C, Watts RL, Currie LJ, Wooten GF, Maher NE, Wilk JB, Sullivan KM, Slater KM, Saint-Hilaire MH, Feldman RG, Suchowersky O, Lafontaine AL, Labelle N, Growdon JH, Vieregge P, Pramstaller PP, Klein C, Hubble JP, Reider CR, Stacy M, MacDonald ME, Gusella JF, Myers RH. PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study. Am J Hum Genet. 2002 May; 70(5):1089-95.
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  112. Joost O, Wilk JB, Cupples LA, Harmon M, Shearman AM, Baldwin CT, O'Connor GT, Myers RH, Gottlieb DJ. Genetic loci influencing lung function: a genome-wide scan in the Framingham Study. Am J Respir Crit Care Med. 2002 Mar 15; 165(6):795-9.
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  113. Meigs JB, Panhuysen CI, Myers RH, Wilson PW, Cupples LA. A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study. Diabetes. 2002 Mar; 51(3):833-40.
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  114. Maher NE, Golbe LI, Lazzarini AM, Mark MH, Currie LJ, Wooten GF, Saint-Hilaire M, Wilk JB, Volcjak J, Maher JE, Feldman RG, Guttman M, Lew M, Waters CH, Schuman S, Suchowersky O, Lafontaine AL, Labelle N, Vieregge P, Pramstaller PP, Klein C, Hubble J, Reider C, Growdon J, Watts R, Montgomery E, Baker K, Singer C, Stacy M, Myers RH. Epidemiologic study of 203 sibling pairs with Parkinson's disease: the GenePD study. Neurology. 2002 Jan 8; 58(1):79-84.
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  115. Baldwin CT, Cupples LA, Joost O, Demissie S, Chaisson C, Mcalindon T, Myers RH, Felson D. Absence of linkage or association for osteoarthritis with the vitamin D receptor/type II collagen locus: the Framingham Osteoarthritis Study. J Rheumatol. 2002 Jan; 29(1):161-5.
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  116. Coon H, Leppert MF, Eckfeldt JH, Oberman A, Myers RH, Peacock JM, Province MA, Hopkins PN, Heiss G. Genome-wide linkage analysis of lipids in the Hypertension Genetic Epidemiology Network (HyperGEN) Blood Pressure Study. Arterioscler Thromb Vasc Biol. 2001 Dec; 21(12):1969-76.
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  117. Feitosa MF, Borecki IB, Rich SS, Arnett DK, Sholinsky P, Myers RH, Leppert M, Province MA. Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet. 2002 Jan; 70(1):72-82.
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  118. Gottlieb DJ, Wilk JB, Harmon M, Evans JC, Joost O, Levy D, O'Connor GT, Myers RH. Heritability of longitudinal change in lung function. The Framingham study. Am J Respir Crit Care Med. 2001 Nov 1; 164(9):1655-9.
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  119. Peacock JM, Arnett DK, Atwood LD, Myers RH, Coon H, Rich SS, Province MA, Heiss G. Genome scan for quantitative trait loci linked to high-density lipoprotein cholesterol: The NHLBI Family Heart Study. Arterioscler Thromb Vasc Biol. 2001 Nov; 21(11):1823-8.
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  120. DeStefano AL, Golbe LI, Mark MH, Lazzarini AM, Maher NE, Saint-Hilaire M, Feldman RG, Guttman M, Watts RL, Suchowersky O, Lafontaine AL, Labelle N, Lew MF, Waters CH, Growdon JH, Singer C, Currie LJ, Wooten GF, Vieregge P, Pramstaller PP, Klein C, Hubble JP, Stacy M, Montgomery E, MacDonald ME, Gusella JF, Myers RH. Genome-wide scan for Parkinson's disease: the GenePD Study. Neurology. 2001 Sep 25; 57(6):1124-6.
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  121. Glorioso N, Filigheddu F, Troffa C, Soro A, Parpaglia PP, Tsikoudakis A, Myers RH, Herrera VL, Ruiz-Opazo N. Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension. Hypertension. 2001 Aug; 38(2):204-9.
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  122. O'Donnell CJ, Larson MG, Feng D, Sutherland PA, Lindpaintner K, Myers RH, D'Agostino RA, Levy D, Tofler GH. Genetic and environmental contributions to platelet aggregation: the Framingham heart study. Circulation. 2001 Jun 26; 103(25):3051-6.
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  123. Hunt SC, Kronenberg F, Eckfeldt JH, Hopkins PN, Myers RH, Heiss G. Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: the NHLBI family heart study. Atherosclerosis. 2001 Feb 15; 154(3):747-54.
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  124. Gómez-Tortosa E, MacDonald ME, Friend JC, Taylor SA, Weiler LJ, Cupples LA, Srinidhi J, Gusella JF, Bird ED, Vonsattel JP, Myers RH. Quantitative neuropathological changes in presymptomatic Huntington's disease. Ann Neurol. 2001 Jan; 49(1):29-34.
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  125. Nance MA, Myers RH. Juvenile onset Huntington's disease--clinical and research perspectives. Ment Retard Dev Disabil Res Rev. 2001; 7(3):153-7.
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  126. Myers RH, Cupples LA, Taylor CA, Saint-Hilaire MH, Auerbach S, Feldman RG, Farrer LA. . The genetic component in Parkinson’s disease is half that of Alzheimer’s disease. Alzheimer’s Reports. 2001; 4:9-15.
  127. Heard-Costa NL, Demissie S, DeStefano AL, Knowlton BA, Maher NE, Myers RH, Volcjak JS, Wilk JB, Cupples LA. Influence of marker heterozygosity and genetic heterogeneity on fine mapping. Genet Epidemiol. 2001; 21 Suppl 1:S467-72.
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  128. Wilk JB, Volcjak JS, Myers RH, Maher NE, Knowlton BA, Heard-Costa NL, Demissie S, Cupples LA, DeStefano AL. Family-based association tests for qualitative and quantitative traits using single-nucleotide polymorphism and microsatellite data. Genet Epidemiol. 2001; 21 Suppl 1:S364-9.
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  129. Zee RY, Myers RH, Hannan MT, Wilson PW, Ordovas JM, Schaefer EJ, Lindpaintner K, Kiel DP. Absence of linkage for bone mineral density to chromosome 12q12-14 in the region of the vitamin D receptor gene. Calcif Tissue Int. 2000 Dec; 67(6):434-9.
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  130. Coon H, Myers RH, Borecki IB, Arnett DK, Hunt SC, Province MA, Djousse L, Leppert MF. Replication of linkage of familial combined hyperlipidemia to chromosome 1q with additional heterogeneous effect of apolipoprotein A-I/C-III/A-IV locus. The NHLBI Family Heart Study. Arterioscler Thromb Vasc Biol. 2000 Oct; 20(10):2275-80.
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  131. Levy D, DeStefano AL, Larson MG, O'Donnell CJ, Lifton RP, Gavras H, Cupples LA, Myers RH. Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension. 2000 Oct; 36(4):477-83.
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  132. Djoussé L, Myers RH, Coon H, Arnett DK, Province MA, Ellison RC. Smoking influences the association between apolipoprotein E and lipids: the National Heart, Lung, and Blood Institute Family Heart Study. Lipids. 2000 Aug; 35(8):827-31.
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  133. Wilk JB, Djousse L, Arnett DK, Rich SS, Province MA, Hunt SC, Crapo RO, Higgins M, Myers RH. Evidence for major genes influencing pulmonary function in the NHLBI family heart study. Genet Epidemiol. 2000 Jul; 19(1):81-94.
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  134. Salomaa V, Pankow J, Heiss G, Cakir B, Eckfeldt JH, Ellison RC, Myers RH, Hiller KM, Brantley KR, Morris TL, Weston BW. Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI family heart study. J Intern Med. 2000 Jun; 247(6):689-98.
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  135. Shearman AM, Ordovas JM, Cupples LA, Schaefer EJ, Harmon MD, Shao Y, Keen JD, DeStefano AL, Joost O, Wilson PW, Housman DE, Myers RH. Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study. Hum Mol Genet. 2000 May 22; 9(9):1315-20.
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  136. Wilk JB, Djousse L, Borecki I, Atwood LD, Hunt SC, Rich SS, Eckfeldt JH, Arnett DK, Rao DC, Myers RH. Segregation analysis of serum uric acid in the NHLBI Family Heart Study. Hum Genet. 2000 Mar; 106(3):355-9.
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  137. Hong Y, Leppert MF, Lin J, Hunt SC, Rich SS, Arnett DK, Myers RH, Eckfeldt J, Williams RR, Province MA. No evidence of linkage between the very-low-density lipoprotein receptor gene and fasting serum insulin or homeostasis model assessment insulin resistance index: the National Heart, Lung, and Blood Institute Family Heart Study. Metabolism. 2000 Mar; 49(3):293-7.
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  138. Kronenberg F, Rich SS, Sholinsky P, Arnett DK, Province ME, Myers RH, Eckfeldt JH, Williams RR, Hunt SC. Insulin and hypertension in the NHLBI Family Heart Study: a sibpair approach to a controversial issue. Am J Hypertens. 2000 Mar; 13(3):240-50.
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  139. Marder K, Zhao H, Myers RH, Cudkowicz M, Kayson E, Kieburtz K, Orme C, Paulsen J, Penney JB, Siemers E, Shoulson I. Rate of functional decline in Huntington's disease. Huntington Study Group. Neurology. 2000 Jan 25; 54(2):452-8.
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  140. Myers RH . Genetic modifiers and predictive testing in Huntington’s disease. NeuroScience News. Editor: Patrick McGeer. 2000; 3:23-29.
  141. Taylor CA, Saint-Hilaire MH, Cupples LA, Thomas CA, Burchard AE, Feldman RG, Myers RH. Environmental, medical, and family history risk factors for Parkinson's disease: a New England-based case control study. Am J Med Genet. 1999 Dec 15; 88(6):742-9.
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  142. Zhang Y, Kreger BE, Dorgan JF, Cupples LA, Myers RH, Splansky GL, Schatzkin A, Ellison RC. Parental age at child's birth and son's risk of prostate cancer. The Framingham Study. Am J Epidemiol. 1999 Dec 1; 150(11):1208-12.
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  143. Ellison RC, Myers RH, Zhang Y, Djoussé L, Knox S, Williams RR, Province MA. Effects of similarities in lifestyle habits on familial aggregation of high density lipoprotein and low density lipoprotein cholesterol: the NHLBI Family Heart Study. Am J Epidemiol. 1999 Nov 1; 150(9):910-8.
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  144. MacDonald ME, Vonsattel JP, Shrinidhi J, Couropmitree NN, Cupples LA, Bird ED, Gusella JF, Myers RH. Evidence for the GluR6 gene associated with younger onset age of Huntington's disease. Neurology. 1999 Oct 12; 53(6):1330-2.
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  145. Coon H, Leppert MF, Kronenberg F, Province MA, Myers RH, Arnett DK, Eckfeldt JH, Heiss G, Williams RR, Hunt SC. Evidence for a major gene accounting for mild elevation in LDL cholesterol: the NHLBI Family Heart Study. Ann Hum Genet. 1999 Sep; 63(Pt 5):401-12.
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  146. Joost O, Taylor CA, Thomas CA, Cupples LA, Saint-Hilaire MH, Feldman RG, Baldwin CT, Myers RH. Absence of effect of seven functional mutations in the CYP2D6 gene in Parkinson's disease. Mov Disord. 1999 Jul; 14(4):590-5.
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  147. Gates GA, Couropmitree NN, Myers RH. Genetic associations in age-related hearing thresholds. Arch Otolaryngol Head Neck Surg. 1999 Jun; 125(6):654-9.
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  148. Feng D, Lindpaintner K, Larson MG, Rao VS, O'Donnell CJ, Lipinska I, Schmitz C, Sutherland PA, Silbershatz H, D'Agostino RB, Muller JE, Myers RH, Levy D, Tofler GH. Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: the Framingham Offspring Study. Arterioscler Thromb Vasc Biol. 1999 Apr; 19(4):1142-7.
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  149. Ellison RC, Zhang Y, Myers RH, Swanson JL, Higgins M, Eckfeldt J. Lewis blood group phenotype as an independent risk factor for coronary heart disease (the NHLBI Family Heart Study). Am J Cardiol. 1999 Feb 1; 83(3):345-8.
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  150. Wilk JB, Premkumar S, Nicolaou M, Myers RH, Maher NE, Harmon MD, Farrer LA, DeStefano AL, Cupples LA, Couropmitree NN. Stratification techniques to explore genotype environment interactions. Genet Epidemiol. 1999; 17 Suppl 1:S761-6.
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  151. Sieradzan KA, Mann DM. On the pathological progression of Huntington's disease. Ann Neurol. 1998 Jul; 44(1):148-9.
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  152. Pocovi M, Cenarro A, Civeira F, Torralba MA, Perez-Calvo JI, Mozas P, Giraldo P, Giralt M, Myers RH, Cupples LA, Ordovas JM. Beta-glucocerebrosidase gene locus as a link for Gaucher's disease and familial hypo-alpha-lipoproteinaemia. Lancet. 1998 Jun 27; 351(9120):1919-23.
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  153. Felson DT, Couropmitree NN, Chaisson CE, Hannan MT, Zhang Y, McAlindon TE, LaValley M, Levy D, Myers RH. Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study. Arthritis Rheum. 1998 Jun; 41(6):1064-71.
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  154. O'Donnell CJ, Lindpaintner K, Larson MG, Rao VS, Ordovas JM, Schaefer EJ, Myers RH, Levy D. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation. 1998 May 12; 97(18):1766-72.
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  155. Jenkins BG, Rosas HD, Chen YC, Makabe T, Myers R, MacDonald M, Rosen BR, Beal MF, Koroshetz WJ. 1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers. Neurology. 1998 May; 50(5):1357-65.
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  156. Arnett DK, Borecki IB, Ludwig EH, Pankow JS, Myers R, Evans G, Folsom AR, Heiss G, Higgins M. Angiotensinogen and angiotensin converting enzyme genotypes and carotid atherosclerosis: the atherosclerosis risk in communities and the NHLBI family heart studies. Atherosclerosis. 1998 May; 138(1):111-6.
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  157. Givelber RJ, Couropmitree NN, Gottlieb DJ, Evans JC, Levy D, Myers RH, O'Connor GT. Segregation analysis of pulmonary function among families in the Framingham Study. Am J Respir Crit Care Med. 1998 May; 157(5 Pt 1):1445-51.
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  158. ACMG/ASHG statement. Laboratory guidelines for Huntington disease genetic testing. The American College of Medical Genetics/American Society of Human Genetics Huntington Disease Genetic Testing Working Group. Am J Hum Genet. 1998 May; 62(5):1243-7.
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  159. Ewbank DC. Effects of age and ethnicity on the link between APOE epsilon4 and Alzheimer disease. JAMA. 1998 Feb 25; 279(8):580-1; author reply 581-2.
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  160. Feng DL, Lindpaintner K, Larson MG, O'Donnell C, Silbershatz H, Lipinska I, Sutherland PA, Muller JE, D'Agostino RB, Myers RH, Tofler GH . Factor VII gene polymorphism and cardiovascular disease: The Framingham Heart Study Circulation. 1998; 98: 2410-.
  161. Myers RH, Marans K, MacDonald ME . Huntington’s Disease. In: Genetic Instabilities and Hereditary Neurological Diseases. Editors: Stephen T. Warren and Robert T. Wells. Academic Press. 1998; 301-323.
  162. Post WS, Larson MG, Myers RH, Galderisi M, Levy D. Heritability of left ventricular mass: the Framingham Heart Study. Hypertension. 1997 Nov; 30(5):1025-8.
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  163. Liao D, Myers R, Hunt S, Shahar E, Paton C, Burke G, Province M, Heiss G. Familial history of stroke and stroke risk. The Family Heart Study. Stroke. 1997 Oct; 28(10):1908-12.
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  164. Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA. 1997 Oct 22-29; 278(16):1349-56.
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  165. Kiel DP, Myers RH, Cupples LA, Kong XF, Zhu XH, Ordovas J, Schaefer EJ, Felson DT, Rush D, Wilson PW, Eisman JA, Holick MF. The BsmI vitamin D receptor restriction fragment length polymorphism (bb) influences the effect of calcium intake on bone mineral density. J Bone Miner Res. 1997 Jul; 12(7):1049-57.
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  166. Taylor CA, Myers RH. Long-term impact of Huntington disease linkage testing. Am J Med Genet. 1997 Jun 27; 70(4):365-70.
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  167. Penney JB, Vonsattel JP, MacDonald ME, Gusella JF, Myers RH. CAG repeat number governs the development rate of pathology in Huntington's disease. Ann Neurol. 1997 May; 41(5):689-92.
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  168. McNeil SM, Novelletto A, Srinidhi J, Barnes G, Kornbluth I, Altherr MR, Wasmuth JJ, Gusella JF, MacDonald ME, Myers RH. Reduced penetrance of the Huntington's disease mutation. Hum Mol Genet. 1997 May; 6(5):775-9.
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  169. DeStefano AL, Cupples LA, Myers RH, Farrer LA. Detecting linkage for a complex disease using simulated extended pedigrees. Genet Epidemiol. 1997; 14(6):981-6.
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  170. Sax DS, Powsner R, Kim A, Tilak S, Bhatia R, Cupples LA, Myers RH. Evidence of cortical metabolic dysfunction in early Huntington's disease by single-photon-emission computed tomography. Mov Disord. 1996 Nov; 11(6):671-7.
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  171. Pocovi M, Cenarro A, Civeira F, Myers RH, Casao E, Esteban M, Ordovas JM. Incomplete dominance of type III hyperlipoproteinemia is associated with the rare apolipoprotein E2 (Arg136-->Ser) variant in multigenerational pedigree studies. Atherosclerosis. 1996 Apr 26; 122(1):33-46.
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  172. Lindpaintner K, Lee M, Larson MG, Rao VS, Pfeffer MA, Ordovas JM, Schaefer EJ, Wilson AF, Wilson PW, Vasan RS, Myers RH, Levy D. Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass. N Engl J Med. 1996 Apr 18; 334(16):1023-8.
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  173. Myers RH, Schaefer EJ, Wilson PW, D'Agostino R, Ordovas JM, Espino A, Au R, White RF, Knoefel JE, Cobb JL, McNulty KA, Beiser A, Wolf PA. Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study. Neurology. 1996 Mar; 46(3):673-7.
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  174. Podgor MJ, Hiller R. Associations of types of lens opacities between and within eyes of individuals: an application of second-order generalized estimating equations. The Framingham Eye Studies Group. Stat Med. 1996 Jan 30; 15(2):145-56.
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  175. Gusella JF, McNeil S, Persichetti F, Srinidhi J, Novelletto A, Bird E, Faber P, Vonsattel JP, Myers RH, MacDonald ME. Huntington's disease. Cold Spring Harb Symp Quant Biol. 1996; 61:615-26.
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  176. Leeflang EP, Zhang L, Tavaré S, Hubert R, Srinidhi J, MacDonald ME, Myers RH, de Young M, Wexler NS, Gusella JF, et al. Single sperm analysis of the trinucleotide repeats in the Huntington's disease gene: quantification of the mutation frequency spectrum. Hum Mol Genet. 1995 Sep; 4(9):1519-26.
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  177. Persichetti F, Ambrose CM, Ge P, McNeil SM, Srinidhi J, Anderson MA, Jenkins B, Barnes GT, Duyao MP, Kanaley L, et al. Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat. Mol Med. 1995 May; 1(4):374-83.
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  178. Myers RH, Schaefer EJ, Wilson PWF, D'Agostino R, Bachman DL, Ordovas JM, Au R, Cobb JL, Wolf PA . Apolipoprotein E allele 4 is associated with dementia in the Framingham study. In: Research Advances in Alzheimer’s Disease and Related Disorders. Editors: Iqbal K, Mortimer J, Winblad B, Wisniewski H. John Wiley & Sons, Ltd. Chichester England. 1995; 63-70.
  179. Ellison RC, Myers RH. Genetic and Familial Aspects of Disease. In: Introduction to Clinical Medicine. Mosby Yearbook. 1995; 9-12.
  180. Myers RH . Genetic testing for Huntington's disease. Scientific American; Science & Medicine. March/April. 1995; 4.
  181. Wilson PW, Myers RH, Larson MG, Ordovas JM, Wolf PA, Schaefer EJ. Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study. JAMA. 1994 Dec 7; 272(21):1666-71.
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  182. Persichetti F, Srinidhi J, Kanaley L, Ge P, Myers RH, D'Arrigo K, Barnes GT, MacDonald ME, Vonsattel JP, Gusella JF, et al. Huntington's disease CAG trinucleotide repeats in pathologically confirmed post-mortem brains. Neurobiol Dis. 1994 Dec; 1(3):159-66.
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  183. Familial aggregation of lens opacities: the Framingham Eye Study and the Framingham Offspring Eye Study. Am J Epidemiol. 1994 Sep 15; 140(6):555-64.
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  184. Multani P, Myers RH, Blume HW, Schomer DL, Sotrel A. Neocortical dendritic pathology in human partial epilepsy: a quantitative Golgi study. Epilepsia. 1994 Jul-Aug; 35(4):728-36.
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  185. Lazzarini AM, Myers RH, Zimmerman TR, Mark MH, Golbe LI, Sage JI, Johnson WG, Duvoisin RC. A clinical genetic study of Parkinson's disease: evidence for dominant transmission. Neurology. 1994 Mar; 44(3 Pt 1):499-506.
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  186. MacDonald ME, Barnes G, Srinidhi J, Duyao MP, Ambrose CM, Myers RH, Gray J, Conneally PM, Young A, Penney J, et al. Gametic but not somatic instability of CAG repeat length in Huntington's disease. J Med Genet. 1993 Dec; 30(12):982-6.
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  187. Myers RH, MacDonald ME, Gusella JF. Discrepancy resolved. Nat Genet. 1993 Nov; 5(3):215.
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  188. Myers RH, MacDonald ME, Koroshetz WJ, Duyao MP, Ambrose CM, Taylor SA, Barnes G, Srinidhi J, Lin CS, Whaley WL, et al. De novo expansion of a (CAG)n repeat in sporadic Huntington's disease. Nat Genet. 1993 Oct; 5(2):168-73.
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  189. Sotrel A, Williams RS, Kaufmann WE, Myers RH. Evidence for neuronal degeneration and dendritic plasticity in cortical pyramidal neurons of Huntington's disease: a quantitative Golgi study. Neurology. 1993 Oct; 43(10):2088-96.
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  190. Kiely DK, Wolf PA, Cupples LA, Beiser AS, Myers RH. Familial aggregation of stroke. The Framingham Study. Stroke. 1993 Sep; 24(9):1366-71.
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  191. Duyao M, Ambrose C, Myers R, Novelletto A, Persichetti F, Frontali M, Folstein S, Ross C, Franz M, Abbott M, et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nat Genet. 1993 Aug; 4(4):387-92.
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  192. Farrer LA, Cupples LA, Wiater P, Conneally PM, Gusella JF, Myers RH. The normal Huntington disease (HD) allele, or a closely linked gene, influences age at onset of HD. Am J Hum Genet. 1993 Jul; 53(1):125-30.
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  193. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell. 1993 Mar 26; 72(6):971-83.
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  194. Koroshetz WJ, Myers RH, Martin JB. Neurology of Huntington's disease. In: The Molecular and Genetic Basis of Neurological Disease. Editors: Rosenberg RN, Prusiner SB, DiMauro S, Barchi RL, Kunkel LM. Butterworth & Heinemann. Boston,MA. 1993; 737-751.
  195. Cupples LA, Myers RH. Segregation analysis for high density lipoprotein in the Berkeley data. Genet Epidemiol. 1993; 10(6):629-34.
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  196. Diamond R, White RF, Myers RH, Mastromauro C, Koroshetz WJ, Butters N, Rothstein DM, Moss MB, Vasterling J. Evidence of presymptomatic cognitive decline in Huntington's disease. J Clin Exp Neuropsychol. 1992 Nov; 14(6):961-75.
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  197. Ogawa T, Matson WR, Beal MF, Myers RH, Bird ED, Milbury P, Saso S. Kynurenine pathway abnormalities in Parkinson's disease. Neurology. 1992 Sep; 42(9):1702-6.
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  198. Genest JJ, Martin-Munley SS, McNamara JR, Ordovas JM, Jenner J, Myers RH, Silberman SR, Wilson PW, Salem DN, Schaefer EJ. Familial lipoprotein disorders in patients with premature coronary artery disease. Circulation. 1992 Jun; 85(6):2025-33.
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  199. MacDonald ME, Novelletto A, Lin C, Tagle D, Barnes G, Bates G, Taylor S, Allitto B, Altherr M, Myers R, et al. The Huntington's disease candidate region exhibits many different haplotypes. Nat Genet. 1992 May; 1(2):99-103.
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  200. Farrer LA, Cupples LA, Kiely DK, Conneally PM, Myers RH. Inverse relationship between age at onset of Huntington disease and paternal age suggests involvement of genetic imprinting. Am J Hum Genet. 1992 Mar; 50(3):528-35.
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  201. Brand FN, Kiely DK, Kannel WB, Myers RH. Family patterns of coronary heart disease mortality: the Framingham Longevity Study. J Clin Epidemiol. 1992 Feb; 45(2):169-74.
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  202. White RF, Vasterling J, Koroshetz W, Myers RH . Neuropsychology of Huntington's disease. In: Clinical Syn­dromes in Adult Neuropsychology: The Practitioner's Handbook. Editor: White RF. Elsevier. Amsterdam. 1992; 213-251.
  203. Vonsattel JP, Myers RH, Bird ED, Ge P, Richardson EP. [Huntington disease: 7 cases with relatively preserved neostriatal islets]. Rev Neurol (Paris). 1992; 148(2):107-16.
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  204. Farrer LA, Myers RH, Cupples LA. Segregation analysis of total nevus density and estimation of lifetime risk and average onset age of melanoma. Cytogenet Cell Genet. 1992; 59(2-3):197-9.
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  205. Koroshetz WJ, Myers RH, Martin JB. The Neurology of Huntington's disease. In: Movement Disorders in Neurology and Neuropsychiatry. Editors: Joseph AR and Young RR. Blackwell Scientific Publications. Cambridge,MA. 1992; 167-177.
  206. Myers RH, Vonsattel JP, Paskevich PA, Kiely DK, Stevens TJ, Cupples LA, Richardson EP, Bird ED. Decreased neuronal and increased oligodendroglial densities in Huntington's disease caudate nucleus. J Neuropathol Exp Neurol. 1991 Nov; 50(6):729-42.
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  207. Vonsattel JP, Myers RH, Hedley-Whyte ET, Ropper AH, Bird ED, Richardson EP. Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study. Ann Neurol. 1991 Nov; 30(5):637-49.
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  208. Myers RH, Sax DS, Koroshetz WJ, Mastromauro C, Cupples LA, Kiely DK, Pettengill FK, Bird ED. Factors associated with slow progression in Huntington's disease. Arch Neurol. 1991 Aug; 48(8):800-4.
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  209. Sotrel A, Paskevich PA, Kiely DK, Bird ED, Williams RS, Myers RH. Morphometric analysis of the prefrontal cortex in Huntington's disease. Neurology. 1991 Jul; 41(7):1117-23.
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  210. Cupples LA, Risch N, Farrer LA, Myers RH. Estimation of morbid risk and age at onset with missing information. Am J Hum Genet. 1991 Jul; 49(1):76-87.
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  211. Meissen GJ, Mastromauro CA, Kiely DK, McNamara DS, Myers RH. Understanding the decision to take the predictive test for Huntington disease. Am J Med Genet. 1991 Jun 15; 39(4):404-10.
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  212. Farrer LA, Myers RH, Connor L, Cupples LA, Growdon JH. Segregation analysis reveals evidence of a major gene for Alzheimer disease. Am J Hum Genet. 1991 Jun; 48(6):1026-33.
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  213. Doolittle TH, Myers RH, Lehrich JR, Birnbaum G, Sheremata W, Franklin GM, Nelson LM, Hauser SL. Multiple sclerosis sibling pairs: clustered onset and familial predisposition. Neurology. 1990 Oct; 40(10):1546-52.
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  214. Myers RH, Kiely DK, Cupples LA, Kannel WB. Parental history is an independent risk factor for coronary artery disease: the Framingham Study. Am Heart J. 1990 Oct; 120(4):963-9.
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  215. St George-Hyslop PH, Haines JL, Farrer LA, Polinsky R, Van Broeckhoven C, Goate A, McLachlan DR, Orr H, Bruni AC, Sorbi S, Rainero I, Foncin JF, Pollen D, Cantu JM, Tupler R, Voskresenskaya N, Mayeux R, Growden J, Fried VA, Myers RH, Nee L, Backhovens H, Martin JJ, Rossor M, Owen MJ, Mullan M, Percy ME, Karlinsky H, Rich S, Heston L, Montesi M, Mortilla M, Nacmias N, Gusella JF, Hardy JA, et al. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature. 1990 Sep 13; 347(6289):194-7.
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  216. Farrer LA, Myers RH, Cupples LA, St George-Hyslop PH, Bird TD, Rossor MN, Mullan MJ, Polinsky R, Nee L, Heston L, et al. Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity. Neurology. 1990 Mar; 40(3 Pt 1):395-403.
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  217. St George-Hyslop PH, Haines JL, Polinsky RJ, Tanzi RE, Farrer L, Myers RH, Gusella JF. Molecular genetics of familial Alzheimer's disease. Can J Neurol Sci. 1989 Nov; 16(4 Suppl):465-7.
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  218. Myers RH, Leavitt J, Farrer LA, Jagadeesh J, McFarlane H, Mastromauro CA, Mark RJ, Gusella JF. Homozygote for Huntington disease. Am J Hum Genet. 1989 Oct; 45(4):615-8.
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  219. Sax DS, Bird ED, Gusella JF, Myers RH. Phenotypic variation in 2 Huntington's disease families with linkage to chromosome 4. Neurology. 1989 Oct; 39(10):1332-6.
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  220. Schildkraut JM, Myers RH, Cupples LA, Kiely DK, Kannel WB. Coronary risk associated with age and sex of parental heart disease in the Framingham Study. Am J Cardiol. 1989 Sep 15; 64(10):555-9.
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  221. MacDonald ME, Cheng SV, Zimmer M, Haines JL, Poustka A, Allitto B, Smith B, Whaley WL, Romano DM, Jagadeesh J, et al. Clustering of multiallele DNA markers near the Huntington's disease gene. J Clin Invest. 1989 Sep; 84(3):1013-6.
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  222. St George-Hyslop PH, Myers RH, Haines JL, Farrer LA, Tanzi RE, Abe K, James MF, Conneally PM, Polinsky RJ, Gusella JF. Familial Alzheimer's disease: progress and problems. Neurobiol Aging. 1989 Sep-Oct; 10(5):417-25.
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  223. Conneally PM, Haines JL, Tanzi RE, Wexler NS, Penchaszadeh GK, Harper PS, Folstein SE, Cassiman JJ, Myers RH, Young AB, et al. Huntington disease: no evidence for locus heterogeneity. Genomics. 1989 Aug; 5(2):304-8.
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  224. Mastromauro CA, Meissen GJ, Cupples LA, Kiely DK, Berkman B, Myers RH. Estimation of fertility and fitness in Huntington disease in New England. Am J Med Genet. 1989 Jun; 33(2):248-54.
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  225. Farrer LA, O'Sullivan DM, Cupples LA, Growdon JH, Myers RH. Assessment of genetic risk for Alzheimer's disease among first-degree relatives. Ann Neurol. 1989 May; 25(5):485-93.
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  226. St George-Hyslop PH, Tanzi RE, Haines JL, Polinsky RJ, Farrer L, Myers RH, Gusella JF. Molecular genetics of familial Alzheimer's disease. Eur Neurol. 1989; 29 Suppl 3:25-7.
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  227. Cupples LA, Terrin NC, Myers RH, D'Agostino RB. Using survival methods to estimate age-at-onset distributions for genetic diseases with an application to Huntington disease. Genet Epidemiol. 1989; 6(2):361-71.
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  228. Haines JL, Farrer LA, Myers RH. Linkage map of anonymous loci near the CF gene. Prog Clin Biol Res. 1989; 329:29-34.
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  229. Farrer LA, Myers RH, Cupples LA, Conneally PM. Considerations in using linkage analysis as a presymptomatic test for Huntington's disease. J Med Genet. 1988 Sep; 25(9):577-88.
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  230. Meissen GJ, Myers RH, Mastromauro CA, Koroshetz WJ, Klinger KW, Farrer LA, Watkins PA, Gusella JF, Bird ED, Martin JB. Predictive testing for Huntington's disease with use of a linked DNA marker. N Engl J Med. 1988 Mar 3; 318(9):535-42.
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  231. Myers RH, Vonsattel JP, Stevens TJ, Cupples LA, Richardson EP, Martin JB, Bird ED. Clinical and neuropathologic assessment of severity in Huntington's disease. Neurology. 1988 Mar; 38(3):341-7.
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  232. Gilliam TC, Bucan M, MacDonald ME, Zimmer M, Haines JL, Cheng SV, Pohl TM, Meyers RH, Whaley WL, Allitto BA, et al. A DNA segment encoding two genes very tightly linked to Huntington's disease. Science. 1987 Nov 13; 238(4829):950-2.
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  233. St George-Hyslop PH, Tanzi RE, Polinsky RJ, Neve RL, Pollen D, Drachman D, Growdon J, Cupples LA, Nee L, Myers RH, et al. Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease. Science. 1987 Oct 30; 238(4827):664-6.
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  234. Mastromauro C, Myers RH, Berkman B. Attitudes toward presymptomatic testing in Huntington disease. Am J Med Genet. 1987 Feb; 26(2):271-82.
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  235. Myers RH . Genetic linkage test for Huntington's disease. The Genetic Resource. 1987; 4:15-18.
  236. Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Paskevich PA, Bird ED, Richardson EP. Huntington's disease: Neuropathological grading. In: The Basal Ganglia: Structure and Function. Editors: Carpenter MB, Jayaraman A. Plenum Press. New York,NY. 1987; 515-531.
  237. St George-Hyslop P, Polinsky R, Haines J, Nee L, Tanzi R, Conneally P, Growdon J, Myers R, Pollen D, Drachman D, et al. Search for the familial Alzheimer's disease gene. J Neural Transm Suppl. 1987; 24:13-21.
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  238. Gusella JF, St. George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, Watkins PC, Steward GD, Neve R, Bruns GA, Myers RH, Feldman RG, Pollen D, Drachman D, Bruni A, Foncin JF, Frommelt P, Amaducci L, Conneally PM. . Genetic Linkage analysis of familial Alzheimer's disease. In: Molecular Neuropathology of Aging. Davies P, Finch CE (Editors). Banbury Report 27, Cold Spring Harbor Laboratory. 1987; 425-442.
  239. Mastromauro C, Myers RH, Berkman B. Change in attitudes toward presymptomatic testing in Huntington disease. Am J Med Genet. 1986 Jun; 24(2):369-71.
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  240. Falek A, Myers RH, Craddick R. Prediction in the onset and detection of Huntington's disease. In: Life Span Research on the Prediction of Psychopathology. Editors: Erlenmayer-Kimling L, Miller N, Dohrenwend BS. Erlbaum Publishers. New York,NY. 1986; 275-285.
  241. Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP. Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol. 1985 Nov; 44(6):559-77.
    View in: PubMed
  242. Myers RH, Sax DS, Schoenfeld M, Bird ED, Wolf PA, Vonsattel JP, White RF, Martin JB. Late onset of Huntington's disease. J Neurol Neurosurg Psychiatry. 1985 Jun; 48(6):530-4.
    View in: PubMed
  243. Myers RH, Cupples LA, Schoenfeld M, D'Agostino RB, Terrin NC, Goldmakher N, Wolf PA. Maternal factors in onset of Huntington disease. Am J Hum Genet. 1985 May; 37(3):511-23.
    View in: PubMed
  244. Myers RH, Schoenfeld M, Bird ED. Huntington's disease: genetics, chemical pathology, and management. Prog Med Genet. 1985; 6:91-122.
    View in: PubMed
  245. Shafer DA, Myers RH, Saltzman D. Siabon (Siamang-Gibbon) Hybrids. In: The Lesser Apes: Evolutionary and Behavioral Biology. Editors: Preushoft H, Chivers D, Brockelman W, Creel N. Edinburgh University Press. Edin­burgh. 1985.
  246. Schoenfeld M, Myers RH, Cupples LA, Berkman B, Sax DS, Clark E. Increased rate of suicide among patients with Huntington's disease. J Neurol Neurosurg Psychiatry. 1984 Dec; 47(12):1283-7.
    View in: PubMed
  247. Schoenfeld M, Myers RH, Berkman B, Clark E. Potential impact of a predictive test on the gene frequency of Huntington disease. Am J Med Genet. 1984 Jul; 18(3):423-9.
    View in: PubMed
  248. Savage D, Padgett S, Myers R, Anderson S, Levy D, Plehn J, Finizola B, Castelli W. Noninvasive cardiology tools and endpoints in genetic epidemiology: the Framingham Study. Prog Clin Biol Res. 1984; 147:407-17.
    View in: PubMed
  249. Schoenfeld M, Berkman B, Myers RH, Clark E. Attitudes toward marriage and childbearing of individuals at risk for Huntington's disease. Soc Work Health Care. 1984; 9(4):73-81.
    View in: PubMed
  250. Sudarsky L, Myers RH, Walshe TM. Huntington's disease in monozygotic twins reared apart. J Med Genet. 1983 Dec; 20(6):408-11.
    View in: PubMed
  251. Myers RH, Goldman D, Bird ED, Sax DS, Merril CR, Schoenfeld M, Wolf PA. Maternal transmission in Huntington's disease. Lancet. 1983 Jan 29; 1(8318):208-10.
    View in: PubMed
  252. Myers RH, Growdon JH, Bird ED, Feldman RG, Martin JB. False-negative results with levodopa for early detection of Huntington's disease. N Engl J Med. 1982 Aug 26; 307(9):561-2.
    View in: PubMed
  253. Myers RH, Madden JJ, Teague JL, Falek A. Factors related to onset age of Huntington disease. Am J Hum Genet. 1982 May; 34(3):481-8.
    View in: PubMed
  254. Myers RH, Martin JB. Huntington's Disease. Seminars in Neurology. 1982; 2:365-372.
  255. Sinex FM, Myers RH. Alzheimer's disease, Down's syndrome, and aging: the genetic approach. Ann N Y Acad Sci. 1982; 396:3-13.
    View in: PubMed
  256. Wolkin JR, Myers RH . Characteristics of a Gibbon-Siamang hybrid ape. International Journal of Primatology. 1980; 1:203-221.
  257. Myers RH, Falek A. Quantification of muscle tremor of Huntington's disease patients and their offspring in an early detection study. Biol Psychiatry. 1979 Oct; 14(5):777-89.
    View in: PubMed
  258. Myers RH, Shafer DA. Hybrid ape offspring of a mating of gibbon and siamang. Science. 1979 Jul 20; 205(4403):308-10.
    View in: PubMed
  259. Myers RH . The chromosome connection: the theory of evolu­tion is evolving. The Sciences. 1979; 20(5):18-20.
  260. Myers RH, De Castro JM. Learned aversions to intracerebral carbachol. Physiol Behav. 1977 Oct; 19(4):467-72.
    View in: PubMed
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