Jean-Jacques Soghomonian

Jean-Jacques Soghomonian, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Anatomy & Neurobiology

PhD, Université de Montréal
MSc, Aix-Marseille Université

Websites

	Anatomy & Neurobiology Faculty
	School of Medicine Faculty
	LinkedIn
	Michael J. Fox Foundation

ORCID : 0000-0001-5950-026X

Research focuses on the functional neuroanatomy of the basal ganglia and the neurobiological basis of motor control, sensorimotor integration and learning. We are particularly interested in the mechanisms of regulation of GABAergic neurons in the basal ganglia of normal animals and experimental models of Parkinson's disease. Experimental approaches include analysis of protein/peptide expression by quantitative in situ hybridization histochemistry, immunohistochemistry and Western-blotting and analysis of behavioral activity.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Neurochemical Alterations in the Speech and Language Network in the Autism Brain
03/01/2017 - 09/30/2024 (PI)
Hussman Institute for Autism

Quantitative Neurochemical Analysis of the Basal Ganglia in ASC Impacting Motor, Limbic, and Cognitive Regions and their Interactions with Thalmo-cortical and Cerebellar Projections
01/15/2015 - 05/31/2018 (PI)
The John P. Hussman Foundation

Role of Gad1 in I-DOPA- Induced Dyskinesa
09/01/2011 - 12/31/2013 (PI)
Michael J. Fox Foundation for Parkinson's Research

Behavioral Sensitization and Parkinson’s Disease
03/01/2002 - 08/31/2008 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5 R01 NS40783 05

Levodopa-Induced Plasticity in the Basal Ganglia
04/01/2002 - 03/31/2004 (Dept Sponsor)
NIH/National Institute of Neurological Disorders & Stroke
5 F31 NS42499 02

Effects of Intermittent vs Continuous L-DOPA on GABAergic Neurons of the Basal Ganglia
07/01/2000 - 06/30/2001 (PI)
Parkinson's Disease Foundation

Title

Yr	Title	Project-Sub Proj	Pubs
2006	Behavioral Sensitization and Parkinson's Disease	5R01NS040783-05	8
2005	Behavioral Sensitization and Parkinson's Disease	5R01NS040783-04	8
2004	Behavioral Sensitization and Parkinson's Disease	5R01NS040783-03	8
2003	Behavioral Sensitization and Parkinson's Disease	5R01NS040783-02	8
2002	Behavioral Sensitization and Parkinson's Disease	1R01NS040783-01A2	8

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Soghomonian JJ. The cortico-striatal circuitry in autism-spectrum disorders: a balancing act. Front Cell Neurosci. 2023; 17:1329095. PMID: 38273975; PMCID: PMC10808402; DOI: 10.3389/fncel.2023.1329095;

Brandenburg C, Soghomonian JJ, Zhang K, Sulkaj I, Randolph B, Kachadoorian M, Blatt GJ. Increased Dopamine Type 2 Gene Expression in the Dorsal Striatum in Individuals With Autism Spectrum Disorder Suggests Alterations in Indirect Pathway Signaling and Circuitry. Front Cell Neurosci. 2020; 14:577858. PMID: 33240045; PMCID: PMC7681004; DOI: 10.3389/fncel.2020.577858;

Subramanian K, Brandenburg C, Orsati F, Soghomonian JJ, Hussman JP, Blatt GJ. Basal ganglia and autism - a translational perspective. Autism Res. 2017 Nov; 10(11):1751-1775. PMID: 28730641

Soghomonian JJ, Zhang K, Reprakash S, Blatt GJ. Decreased parvalbumin mRNA levels in cerebellar Purkinje cells in autism. Autism Res. 2017 Nov; 10(11):1787-1796.View Related Profiles.

Soghomonian, Jean-Jacques
Zhang, Kunzhong

PMID: 28707805

Zhang K, Chammas C, Soghomonian JJ. Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice. Neuroscience. 2015 Sep 10; 303:586-94.View Related Profiles.

Soghomonian, Jean-Jacques
Zhang, Kunzhong

PMID: 26188284; DOI: 10.1016/j.neuroscience.2015.07.032;

Zhang K, Hill K, Labak S, Blatt GJ, Soghomonian JJ. Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in mice. Neuroscience. 2014 Sep 5; 275:238-47.View Related Profiles.

Blatt, Gene
Soghomonian, Jean-Jacques
Zhang, Kunzhong

PMID: 24952328; DOI: 10.1016/j.neuroscience.2014.06.020;

Lanoue AC, Blatt GJ, Soghomonian JJ. Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson's disease. Brain Res. 2013 Sep 19; 1531:37-47.View Related Profiles.

Blatt, Gene
Soghomonian, Jean-Jacques

PMID: 23891794; PMCID: PMC3816277; DOI: 10.1016/j.brainres.2013.07.025;

Lanoue AC, Dumitriu A, Myers RH, Soghomonian JJ. Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease. Exp Neurol. 2010 Nov; 226(1):207-17.View Related Profiles.

Dumitriu, Alexandra
Soghomonian, Jean-Jacques
Myers, Richard

PMID: 20832408; PMCID: PMC3108022; DOI: 10.1016/j.expneurol.2010.09.001;

Soghomonian JJ, Sethares C, Peters A. Effects of age on axon terminals forming axosomatic and axodendritic inhibitory synapses in prefrontal cortex. Neuroscience. 2010 Jun 16; 168(1):74-81.View Related Profiles.

Peters, Alan
Soghomonian, Jean-Jacques

PMID: 20302918; PMCID: PMC2873101; DOI: 10.1016/j.neuroscience.2010.03.020;

Yamamoto N, Soghomonian JJ. Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats. Neuroscience. 2009 Nov 10; 163(4):1171-80. PMID: 19660528; PMCID: PMC2760628; DOI: 10.1016/j.neuroscience.2009.07.060;

Showing 10 of 60 results. Show More

Yip J, Soghomonian JJ, Blatt GJ. Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study. Autism Res. 2009 Feb; 2(1):50-9.View Related Profiles.

Blatt, Gene
Soghomonian, Jean-Jacques

PMID: 19358307; PMCID: PMC2724747; DOI: 10.1002/aur.62;

Yamamoto N, Soghomonian JJ. Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6-hydroxydopamine lesion. Neuroscience. 2008 Jun 26; 154(3):1088-99. PMID: 18495353; PMCID: PMC2483836; DOI: 10.1016/j.neuroscience.2008.04.015;

Yip J, Soghomonian JJ, Blatt GJ. Increased GAD67 mRNA expression in cerebellar interneurons in autism: implications for Purkinje cell dysfunction. J Neurosci Res. 2008 Feb 15; 86(3):525-30.View Related Profiles.

Blatt, Gene
Soghomonian, Jean-Jacques

PMID: 17918742

Hatzipetros T, Raudensky JG, Soghomonian JJ, Yamamoto BK. Haloperidol treatment after high-dose methamphetamine administration is excitotoxic to GABA cells in the substantia nigra pars reticulata. J Neurosci. 2007 May 30; 27(22):5895-902. PMID: 17537960; PMCID: PMC6672246; DOI: 10.1523/JNEUROSCI.5260-06.2007;

Yip J, Soghomonian JJ, Blatt GJ. Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications. Acta Neuropathol. 2007 May; 113(5):559-68.View Related Profiles.

Blatt, Gene
Soghomonian, Jean-Jacques

PMID: 17235515

Wang H, Katz J, Dagostino P, Soghomonian JJ. Unilateral 6-hydroxydopamine lesion of dopamine neurons and subchronic L-DOPA administration in the adult rat alters the expression of the vesicular GABA transporter in different subsets of striatal neurons and in the substantia nigra, pars reticulata. Neuroscience. 2007 Mar 16; 145(2):727-37. PMID: 17218060; PMCID: PMC1894759; DOI: 10.1016/j.neuroscience.2006.12.001;

Yamamoto N, Pierce RC, Soghomonian JJ. Subchronic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine lesion of dopamine neurons results in a sensitization of enhanced GABA release in the substantia nigra, pars reticulata. Brain Res. 2006 Dec 6; 1123(1):196-200. PMID: 17027936

Soghomonian JJ. L-DOPA-induced dyskinesia in adult rats with a unilateral 6-OHDA lesion of dopamine neurons is paralleled by increased c-fos gene expression in the subthalamic nucleus. Eur J Neurosci. 2006 May; 23(9):2395-403. PMID: 16706847

Katz J, Nielsen KM, Soghomonian JJ. Comparative effects of acute or chronic administration of levodopa to 6-hydroxydopamine-lesioned rats on the expression of glutamic acid decarboxylase in the neostriatum and GABAA receptors subunits in the substantia nigra, pars reticulata. Neuroscience. 2005; 132(3):833-42. PMID: 15837143

Mark KA, Soghomonian JJ, Yamamoto BK. High-dose methamphetamine acutely activates the striatonigral pathway to increase striatal glutamate and mediate long-term dopamine toxicity. J Neurosci. 2004 Dec 15; 24(50):11449-56. PMID: 15601951

Nielsen KM, Soghomonian JJ. Normalization of glutamate decarboxylase gene expression in the entopeduncular nucleus of rats with a unilateral 6-hydroxydopamine lesion correlates with increased GABAergic input following intermittent but not continuous levodopa. Neuroscience. 2004; 123(1):31-42. PMID: 14667439

Nielsen KM, Soghomonian JJ. Dual effects of intermittent or continuous L-DOPA administration on gene expression in the globus pallidus and subthalamic nucleus of adult rats with a unilateral 6-OHDA lesion. Synapse. 2003 Sep 15; 49(4):246-60. PMID: 12827644

Freeman AY, Soghomonian JJ, Pierce RC. Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine. Neuroscience. 2003; 117(1):147-56. PMID: 12605901

Laprade N, Soghomonian JJ. Gene expression of the GAD67 and GAD65 isoforms of glutamate decarboxylase is differentially altered in subpopulations of striatal neurons in adult rats lesioned with 6-OHDA as neonates. Synapse. 1999 Jul; 33(1):36-48. PMID: 10380849

Gervais J, Soghomonian JJ, Richard D, Rouillard C. Dopamine and serotonin interactions in the modulation of the expression of the immediate-early transcription factor, nerve growth factor-inducible B, in the striatum. Neuroscience. 1999; 91(3):1045-54. PMID: 10391482

Bédard PJ, Blanchet PJ, Lévesque D, Soghomonian JJ, Grondin R, Morissette M, Goulet M, Calon F, Falardeau P, Gomez-Mancilla B, Doucet JP, Robertson GS, DiPaolo T. Pathophysiology of L-dopa-induced dyskinesias. Mov Disord. 1999; 14 Suppl 1:4-8. PMID: 10493397

Soghomonian JJ, Martin DL. Two isoforms of glutamate decarboxylase: why? Trends Pharmacol Sci. 1998 Dec; 19(12):500-5. PMID: 9871412

Soghomonian JJ, Laprade N, Sandstrom M, Bruno JP. c-fos gene expression is induced in a subpopulation of striatal neurons following a single administration of a dopamine D1-receptor agonist in adult rats lesioned with 6-OHDA as neonates. Brain Res Mol Brain Res. 1998 Jun 1; 57(1):155-60. PMID: 9630593

Morissette M, Goulet M, Soghomonian JJ, Blanchet PJ, Calon F, Bédard PJ, Di Paolo T. Preproenkephalin mRNA expression in the caudate-putamen of MPTP monkeys after chronic treatment with the D2 agonist U91356A in continuous or intermittent mode of administration: comparison with L-DOPA therapy. Brain Res Mol Brain Res. 1997 Oct 3; 49(1-2):55-62. PMID: 9387863

Soghomonian JJ, Laprade N. Glutamate decarboxylase (GAD67 and GAD65) gene expression is increased in a subpopulation of neurons in the putamen of Parkinsonian monkeys. Synapse. 1997 Oct; 27(2):122-32. PMID: 9266773

Laprade N, Soghomonian JJ. Glutamate decarboxylase (GAD65) gene expression is increased by dopamine receptor agonists in a subpopulation of rat striatal neurons. Brain Res Mol Brain Res. 1997 Sep; 48(2):333-45. PMID: 9332731

Paquet M, Tremblay M, Soghomonian JJ, Smith Y. AMPA and NMDA glutamate receptor subunits in midbrain dopaminergic neurons in the squirrel monkey: an immunohistochemical and in situ hybridization study. J Neurosci. 1997 Feb 15; 17(4):1377-96. PMID: 9006980

Soghomonian JJ, Pedneault S, Blanchet PJ, Goulet M, Di Paolo T, Bédard PJ. L-DOPA regulates glutamate decarboxylases mRNA levels in MPTP-treated monkeys. Brain Res Mol Brain Res. 1996 Jul; 39(1-2):237-40. PMID: 8804732

Laprade N, Radja F, Reader TA, Soghomonian JJ. Dopamine receptor agonists regulate levels of the serotonin 5-HT2A receptor and its mRNA in a subpopulation of rat striatal neurons. J Neurosci. 1996 Jun 1; 16(11):3727-36. PMID: 8642415

Delfs JM, Ciaramitaro VM, Soghomonian JJ, Chesselet MF. Unilateral nigrostriatal lesions induce a bilateral increase in glutamate decarboxylase messenger RNA in the reticular thalamic nucleus. Neuroscience. 1996 Mar; 71(2):383-95. PMID: 9053794

Séguéla P, Haghighi A, Soghomonian JJ, Cooper E. A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. J Neurosci. 1996 Jan 15; 16(2):448-55. PMID: 8551329

Laprade N, Soghomonian JJ. Differential regulation of mRNA levels encoding for the two isoforms of glutamate decarboxylase (GAD65 and GAD67) by dopamine receptors in the rat striatum. Brain Res Mol Brain Res. 1995 Dec 1; 34(1):65-74. PMID: 8750862

Tremblay M, Salin P, Soghomonian JJ. Effect of 6-OHDA lesions on striatal mRNA levels encoding for glutamate receptor subunits. Neuroreport. 1995 Nov 13; 6(16):2225-9. PMID: 8595208

Laprade N, Soghomonian JJ. MK-801 decreases striatal and cortical GAD65 mRNA levels. Neuroreport. 1995 Oct 2; 6(14):1885-9. PMID: 8547590

Chesselet MF, Soghomonian JJ, Salin P. Anatomical localization and regulation of somatostatin gene expression in the basal ganglia and its clinical implications. Ciba Found Symp. 1995; 190:51-9; discussion 59-64. PMID: 7587652

Asselin MC, Soghomonian JJ, Côté PY, Parent A. Striatal changes in preproenkephalin mRNA levels in parkinsonian monkeys. Neuroreport. 1994 Oct 27; 5(16):2137-40. PMID: 7865763

Soghomonian JJ, Pedneault S, Audet G, Parent A. Increased glutamate decarboxylase mRNA levels in the striatum and pallidum of MPTP-treated primates. J Neurosci. 1994 Oct; 14(10):6256-65. PMID: 7931578

Pedneault S, Soghomonian JJ. Glutamate decarboxylase (GAD65) mRNA levels in the striatum and pallidum of MPTP-treated monkeys. Brain Res Mol Brain Res. 1994 Sep; 25(3-4):351-4. PMID: 7808234

Soghomonian JJ. Differential regulation of glutamate decarboxylase and preproenkephalin mRNA levels in the rat striatum. Brain Res. 1994 Mar 21; 640(1-2):146-54. PMID: 8004444

Radja F, el Mansari M, Soghomonian JJ, Dewar KM, Ferron A, Reader TA, Descarries L. Changes of D1 and D2 receptors in adult rat neostriatum after neonatal dopamine denervation: quantitative data from ligand binding, in situ hybridization and iontophoresis. Neuroscience. 1993 Dec; 57(3):635-48. PMID: 7906013

Soghomonian JJ. Effects of neonatal 6-hydroxydopamine injections on glutamate decarboxylase, preproenkephalin and dopamine D2 receptor mRNAs in the adult rat striatum. Brain Res. 1993 Sep 10; 621(2):249-59. PMID: 7902185

Chesselet MF, Mercugliano M, Soghomonian JJ, Salin P, Qin Y, Gonzales C. Regulation of glutamic acid decarboxylase gene expression in efferent neurons of the basal ganglia. Prog Brain Res. 1993; 99:143-54. PMID: 8108545

Soghomonian JJ, Chesselet MF. Effects of nigrostriatal lesions on the levels of messenger RNAs encoding two isoforms of glutamate decarboxylase in the globus pallidus and entopeduncular nucleus of the rat. Synapse. 1992 Jun; 11(2):124-33. PMID: 1626311

Mercugliano M, Soghomonian JJ, Qin Y, Nguyen HQ, Feldblum S, Erlander MG, Tobin AJ, Chesselet MF. Comparative distribution of messenger RNAs encoding glutamic acid decarboxylases (Mr 65,000 and Mr 67,000) in the basal ganglia of the rat. J Comp Neurol. 1992 Apr 15; 318(3):245-54. PMID: 1583162

Soghomonian JJ, Gonzales C, Chesselet MF. Messenger RNAs encoding glutamate-decarboxylases are differentially affected by nigrostriatal lesions in subpopulations of striatal neurons. Brain Res. 1992 Mar 27; 576(1):68-79. PMID: 1515913

Qin Y, Soghomonian JJ, Chesselet MF. Effects of quinolinic acid on messenger RNAs encoding somatostatin and glutamic acid decarboxylases in the striatum of adult rats. Exp Neurol. 1992 Feb; 115(2):200-11. PMID: 1346522

Descarries L, Soghomonian JJ, Garcia S, Doucet G, Bruno JP. Ultrastructural analysis of the serotonin hyperinnervation in adult rat neostriatum following neonatal dopamine denervation with 6-hydroxydopamine. Brain Res. 1992 Jan 8; 569(1):1-13. PMID: 1611468

Soghomonian JJ, Chesselet MF. Lesions of the dopaminergic nigrostriatal pathway alter preprosomatostatin messenger RNA levels in the striatum, the entopeduncular nucleus and the lateral hypothalamus of the rat. Neuroscience. 1991; 42(1):49-59. PMID: 1677745

Dewar KM, Soghomonian JJ, Bruno JP, Descarries L, Reader TA. Elevation of dopamine D2 but not D1 receptors in adult rat neostriatum after neonatal 6-hydroxydopamine denervation. Brain Res. 1990 Dec 17; 536(1-2):287-96. PMID: 2150772

Descarries L, Audet MA, Doucet G, Garcia S, Oleskevich S, Séguéla P, Soghomonian JJ, Watkins KC. Morphology of central serotonin neurons. Brief review of quantified aspects of their distribution and ultrastructural relationships. Ann N Y Acad Sci. 1990; 600:81-92. PMID: 2252339

Soghomonian JJ, Pinard R, Lanoir J. GABA innervation in adult rat oculomotor nucleus: a radioautographic and immunocytochemical study. J Neurocytol. 1989 Jun; 18(3):319-31. PMID: 2746305

Soghomonian JJ, Descarries L, Watkins KC. Serotonin innervation in adult rat neostriatum. II. Ultrastructural features: a radioautographic and immunocytochemical study. Brain Res. 1989 Feb 27; 481(1):67-86. PMID: 2706468

Soghomonian JJ, Doucet G, Descarries L. Serotonin innervation in adult rat neostriatum. I. Quantified regional distribution. Brain Res. 1987 Nov 3; 425(1):85-100. PMID: 2448003

Soghomonian JJ, Descarries L, Lanoir J. Monoamine innervation of the oculomotor nucleus in the rat. A radioautographic study. Neuroscience. 1986 Apr; 17(4):1147-57. PMID: 3714041

Lanoir J, Soghomonian JJ, Cadenel G. Radioautographic study of 3H-GABA uptake in the oculomotor nucleus of the cat. Exp Brain Res. 1982; 48(1):137-43. PMID: 6183140

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 60 publications over 28 distinct years, with a maximum of 5 publications in 1992