Keywords
Last Name

Jean-Jacques Soghomonian, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentAnatomy & Neurobiology
Address72 E. Concord St
Boston MA 02118
Phone(617) 638-4511
ORCID ORCID Icon0000-0001-5950-026X
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Research Expertise & Professional Interests
Research focuses on the functional neuroanatomy of the basal ganglia and the neurobiological basis of motor control, sensorimotor integration and learning. We are particularly interested in the mechanisms of regulation of GABAergic neurons in the basal ganglia of normal animals and experimental models of Parkinson's disease. Experimental approaches include analysis of protein/peptide expression by quantitative in situ hybridization histochemistry, immunohistochemistry and Western-blotting and analysis of behavioral activity.

 Self-Described Keywords
  • Basal Ganglia
  • Chemical and Functional Neuroanatomy
  • GABAergic neurons
  • Gene Expression
  • Monoaminergic neurons
  • Neurotransmitters
  • Parkinson's disease
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Zhang K, Hill K, Labak S, Blatt GJ, Soghomonian JJ. Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in mice. Neuroscience. 2014 Sep 5; 275:238-47.
    View in: PubMed
  2. Lanoue AC, Blatt GJ, Soghomonian JJ. Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson''s disease. Brain Res. 2013 Sep 19; 1531:37-47.
    View in: PubMed
  3. Lanoue AC, Dumitriu A, Myers RH, Soghomonian JJ. Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease. Exp Neurol. 2010 Nov; 226(1):207-17.
    View in: PubMed
  4. Soghomonian JJ, Sethares C, Peters A. Effects of age on axon terminals forming axosomatic and axodendritic inhibitory synapses in prefrontal cortex. Neuroscience. 2010 Jun 16; 168(1):74-81.
    View in: PubMed
  5. Yamamoto N, Soghomonian JJ. Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats. Neuroscience. 2009 Nov 10; 163(4):1171-80.
    View in: PubMed
  6. Yip J, Soghomonian JJ, Blatt GJ. Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study. Autism Res. 2009 Feb; 2(1):50-9.
    View in: PubMed
  7. Yamamoto N, Soghomonian JJ. Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6-hydroxydopamine lesion. Neuroscience. 2008 Jun 26; 154(3):1088-99.
    View in: PubMed
  8. Yip J, Soghomonian JJ, Blatt GJ. Increased GAD67 mRNA expression in cerebellar interneurons in autism: implications for Purkinje cell dysfunction. J Neurosci Res. 2008 Feb 15; 86(3):525-30.
    View in: PubMed
  9. Hatzipetros T, Raudensky JG, Soghomonian JJ, Yamamoto BK. Haloperidol treatment after high-dose methamphetamine administration is excitotoxic to GABA cells in the substantia nigra pars reticulata. J Neurosci. 2007 May 30; 27(22):5895-902.
    View in: PubMed
  10. Yip J, Soghomonian JJ, Blatt GJ. Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications. Acta Neuropathol. 2007 May; 113(5):559-68.
    View in: PubMed
  11. Wang H, Katz J, Dagostino P, Soghomonian JJ. Unilateral 6-hydroxydopamine lesion of dopamine neurons and subchronic L-DOPA administration in the adult rat alters the expression of the vesicular GABA transporter in different subsets of striatal neurons and in the substantia nigra, pars reticulata. Neuroscience. 2007 Mar 16; 145(2):727-37.
    View in: PubMed
  12. Yamamoto N, Pierce RC, Soghomonian JJ. Subchronic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine lesion of dopamine neurons results in a sensitization of enhanced GABA release in the substantia nigra, pars reticulata. Brain Res. 2006 Dec 6; 1123(1):196-200.
    View in: PubMed
  13. Soghomonian JJ. L-DOPA-induced dyskinesia in adult rats with a unilateral 6-OHDA lesion of dopamine neurons is paralleled by increased c-fos gene expression in the subthalamic nucleus. Eur J Neurosci. 2006 May; 23(9):2395-403.
    View in: PubMed
  14. Katz J, Nielsen KM, Soghomonian JJ. Comparative effects of acute or chronic administration of levodopa to 6-hydroxydopamine-lesioned rats on the expression of glutamic acid decarboxylase in the neostriatum and GABAA receptors subunits in the substantia nigra, pars reticulata. Neuroscience. 2005; 132(3):833-42.
    View in: PubMed
  15. Mark KA, Soghomonian JJ, Yamamoto BK. High-dose methamphetamine acutely activates the striatonigral pathway to increase striatal glutamate and mediate long-term dopamine toxicity. J Neurosci. 2004 Dec 15; 24(50):11449-56.
    View in: PubMed
  16. Nielsen KM, Soghomonian JJ. Normalization of glutamate decarboxylase gene expression in the entopeduncular nucleus of rats with a unilateral 6-hydroxydopamine lesion correlates with increased GABAergic input following intermittent but not continuous levodopa. Neuroscience. 2004; 123(1):31-42.
    View in: PubMed
  17. Nielsen KM, Soghomonian JJ. Dual effects of intermittent or continuous L-DOPA administration on gene expression in the globus pallidus and subthalamic nucleus of adult rats with a unilateral 6-OHDA lesion. Synapse. 2003 Sep 15; 49(4):246-60.
    View in: PubMed
  18. Freeman AY, Soghomonian JJ, Pierce RC. Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine. Neuroscience. 2003; 117(1):147-56.
    View in: PubMed
  19. Laprade N, Soghomonian JJ. Gene expression of the GAD67 and GAD65 isoforms of glutamate decarboxylase is differentially altered in subpopulations of striatal neurons in adult rats lesioned with 6-OHDA as neonates. Synapse. 1999 Jul; 33(1):36-48.
    View in: PubMed
  20. Gervais J, Soghomonian JJ, Richard D, Rouillard C. Dopamine and serotonin interactions in the modulation of the expression of the immediate-early transcription factor, nerve growth factor-inducible B, in the striatum. Neuroscience. 1999; 91(3):1045-54.
    View in: PubMed
  21. Bédard PJ, Blanchet PJ, Lévesque D, Soghomonian JJ, Grondin R, Morissette M, Goulet M, Calon F, Falardeau P, Gomez-Mancilla B, Doucet JP, Robertson GS, DiPaolo T. Pathophysiology of L-dopa-induced dyskinesias. Mov Disord. 1999; 14 Suppl 1:4-8.
    View in: PubMed
  22. Soghomonian JJ, Martin DL. Two isoforms of glutamate decarboxylase: why? Trends Pharmacol Sci. 1998 Dec; 19(12):500-5.
    View in: PubMed
  23. Soghomonian JJ, Laprade N, Sandstrom M, Bruno JP. c-fos gene expression is induced in a subpopulation of striatal neurons following a single administration of a dopamine D1-receptor agonist in adult rats lesioned with 6-OHDA as neonates. Brain Res Mol Brain Res. 1998 Jun 1; 57(1):155-60.
    View in: PubMed
  24. Morissette M, Goulet M, Soghomonian JJ, Blanchet PJ, Calon F, Bédard PJ, Di Paolo T. Preproenkephalin mRNA expression in the caudate-putamen of MPTP monkeys after chronic treatment with the D2 agonist U91356A in continuous or intermittent mode of administration: comparison with L-DOPA therapy. Brain Res Mol Brain Res. 1997 Oct 3; 49(1-2):55-62.
    View in: PubMed
  25. Soghomonian JJ, Laprade N. Glutamate decarboxylase (GAD67 and GAD65) gene expression is increased in a subpopulation of neurons in the putamen of Parkinsonian monkeys. Synapse. 1997 Oct; 27(2):122-32.
    View in: PubMed
  26. Laprade N, Soghomonian JJ. Glutamate decarboxylase (GAD65) gene expression is increased by dopamine receptor agonists in a subpopulation of rat striatal neurons. Brain Res Mol Brain Res. 1997 Sep; 48(2):333-45.
    View in: PubMed
  27. Paquet M, Tremblay M, Soghomonian JJ, Smith Y. AMPA and NMDA glutamate receptor subunits in midbrain dopaminergic neurons in the squirrel monkey: an immunohistochemical and in situ hybridization study. J Neurosci. 1997 Feb 15; 17(4):1377-96.
    View in: PubMed
  28. Soghomonian JJ, Pedneault S, Blanchet PJ, Goulet M, Di Paolo T, Bédard PJ. L-DOPA regulates glutamate decarboxylases mRNA levels in MPTP-treated monkeys. Brain Res Mol Brain Res. 1996 Jul; 39(1-2):237-40.
    View in: PubMed
  29. Laprade N, Radja F, Reader TA, Soghomonian JJ. Dopamine receptor agonists regulate levels of the serotonin 5-HT2A receptor and its mRNA in a subpopulation of rat striatal neurons. J Neurosci. 1996 Jun 1; 16(11):3727-36.
    View in: PubMed
  30. Delfs JM, Ciaramitaro VM, Soghomonian JJ, Chesselet MF. Unilateral nigrostriatal lesions induce a bilateral increase in glutamate decarboxylase messenger RNA in the reticular thalamic nucleus. Neuroscience. 1996 Mar; 71(2):383-95.
    View in: PubMed
  31. Séguéla P, Haghighi A, Soghomonian JJ, Cooper E. A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. J Neurosci. 1996 Jan 15; 16(2):448-55.
    View in: PubMed
  32. Laprade N, Soghomonian JJ. Differential regulation of mRNA levels encoding for the two isoforms of glutamate decarboxylase (GAD65 and GAD67) by dopamine receptors in the rat striatum. Brain Res Mol Brain Res. 1995 Dec 1; 34(1):65-74.
    View in: PubMed
  33. Tremblay M, Salin P, Soghomonian JJ. Effect of 6-OHDA lesions on striatal mRNA levels encoding for glutamate receptor subunits. Neuroreport. 1995 Nov 13; 6(16):2225-9.
    View in: PubMed
  34. Laprade N, Soghomonian JJ. MK-801 decreases striatal and cortical GAD65 mRNA levels. Neuroreport. 1995 Oct 2; 6(14):1885-9.
    View in: PubMed
  35. Chesselet MF, Soghomonian JJ, Salin P. Anatomical localization and regulation of somatostatin gene expression in the basal ganglia and its clinical implications. Ciba Found Symp. 1995; 190:51-9; discussion 59-64.
    View in: PubMed
  36. Asselin MC, Soghomonian JJ, Côté PY, Parent A. Striatal changes in preproenkephalin mRNA levels in parkinsonian monkeys. Neuroreport. 1994 Oct 27; 5(16):2137-40.
    View in: PubMed
  37. Soghomonian JJ, Pedneault S, Audet G, Parent A. Increased glutamate decarboxylase mRNA levels in the striatum and pallidum of MPTP-treated primates. J Neurosci. 1994 Oct; 14(10):6256-65.
    View in: PubMed
  38. Pedneault S, Soghomonian JJ. Glutamate decarboxylase (GAD65) mRNA levels in the striatum and pallidum of MPTP-treated monkeys. Brain Res Mol Brain Res. 1994 Sep; 25(3-4):351-4.
    View in: PubMed
  39. Soghomonian JJ. Differential regulation of glutamate decarboxylase and preproenkephalin mRNA levels in the rat striatum. Brain Res. 1994 Mar 21; 640(1-2):146-54.
    View in: PubMed
  40. Radja F, el Mansari M, Soghomonian JJ, Dewar KM, Ferron A, Reader TA, Descarries L. Changes of D1 and D2 receptors in adult rat neostriatum after neonatal dopamine denervation: quantitative data from ligand binding, in situ hybridization and iontophoresis. Neuroscience. 1993 Dec; 57(3):635-48.
    View in: PubMed
  41. Soghomonian JJ. Effects of neonatal 6-hydroxydopamine injections on glutamate decarboxylase, preproenkephalin and dopamine D2 receptor mRNAs in the adult rat striatum. Brain Res. 1993 Sep 10; 621(2):249-59.
    View in: PubMed
  42. Chesselet MF, Mercugliano M, Soghomonian JJ, Salin P, Qin Y, Gonzales C. Regulation of glutamic acid decarboxylase gene expression in efferent neurons of the basal ganglia. Prog Brain Res. 1993; 99:143-54.
    View in: PubMed
  43. Soghomonian JJ, Chesselet MF. Effects of nigrostriatal lesions on the levels of messenger RNAs encoding two isoforms of glutamate decarboxylase in the globus pallidus and entopeduncular nucleus of the rat. Synapse. 1992 Jun; 11(2):124-33.
    View in: PubMed
  44. Mercugliano M, Soghomonian JJ, Qin Y, Nguyen HQ, Feldblum S, Erlander MG, Tobin AJ, Chesselet MF. Comparative distribution of messenger RNAs encoding glutamic acid decarboxylases (Mr 65,000 and Mr 67,000) in the basal ganglia of the rat. J Comp Neurol. 1992 Apr 15; 318(3):245-54.
    View in: PubMed
  45. Soghomonian JJ, Gonzales C, Chesselet MF. Messenger RNAs encoding glutamate-decarboxylases are differentially affected by nigrostriatal lesions in subpopulations of striatal neurons. Brain Res. 1992 Mar 27; 576(1):68-79.
    View in: PubMed
  46. Qin Y, Soghomonian JJ, Chesselet MF. Effects of quinolinic acid on messenger RNAs encoding somatostatin and glutamic acid decarboxylases in the striatum of adult rats. Exp Neurol. 1992 Feb; 115(2):200-11.
    View in: PubMed
  47. Descarries L, Soghomonian JJ, Garcia S, Doucet G, Bruno JP. Ultrastructural analysis of the serotonin hyperinnervation in adult rat neostriatum following neonatal dopamine denervation with 6-hydroxydopamine. Brain Res. 1992 Jan 8; 569(1):1-13.
    View in: PubMed
  48. Soghomonian JJ, Chesselet MF. Lesions of the dopaminergic nigrostriatal pathway alter preprosomatostatin messenger RNA levels in the striatum, the entopeduncular nucleus and the lateral hypothalamus of the rat. Neuroscience. 1991; 42(1):49-59.
    View in: PubMed
  49. Dewar KM, Soghomonian JJ, Bruno JP, Descarries L, Reader TA. Elevation of dopamine D2 but not D1 receptors in adult rat neostriatum after neonatal 6-hydroxydopamine denervation. Brain Res. 1990 Dec 17; 536(1-2):287-96.
    View in: PubMed
  50. Descarries L, Audet MA, Doucet G, Garcia S, Oleskevich S, Séguéla P, Soghomonian JJ, Watkins KC. Morphology of central serotonin neurons. Brief review of quantified aspects of their distribution and ultrastructural relationships. Ann N Y Acad Sci. 1990; 600:81-92.
    View in: PubMed
  51. Soghomonian JJ, Pinard R, Lanoir J. GABA innervation in adult rat oculomotor nucleus: a radioautographic and immunocytochemical study. J Neurocytol. 1989 Jun; 18(3):319-31.
    View in: PubMed
  52. Soghomonian JJ, Descarries L, Watkins KC. Serotonin innervation in adult rat neostriatum. II. Ultrastructural features: a radioautographic and immunocytochemical study. Brain Res. 1989 Feb 27; 481(1):67-86.
    View in: PubMed
  53. Soghomonian JJ, Doucet G, Descarries L. Serotonin innervation in adult rat neostriatum. I. Quantified regional distribution. Brain Res. 1987 Nov 3; 425(1):85-100.
    View in: PubMed
  54. Soghomonian JJ, Descarries L, Lanoir J. Monoamine innervation of the oculomotor nucleus in the rat. A radioautographic study. Neuroscience. 1986 Apr; 17(4):1147-57.
    View in: PubMed
  55. Lanoir J, Soghomonian JJ, Cadenel G. Radioautographic study of 3H-GABA uptake in the oculomotor nucleus of the cat. Exp Brain Res. 1982; 48(1):137-43.
    View in: PubMed
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