Keywords
Last Name

Gene J. Blatt, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentAnatomy & Neurobiology
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-5260
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Research Expertise & Professional Interests
I am investigating the neuropathology and neurochemistry of autism utilizing immunocytochemistry, ligand binding, in situ hybridization, light microscopy and tissue analysis of the limbic system, cerebral cortex, cerebellum and brainstem.

 Self-Described Keywords
  • autism
  • cerebellar neuroanatomy and neurochemistry
  • GABA, 5-HT, glutamate
  • Limbic system neuroanatomy and neurochemistry
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Zhang K, Hill K, Labak S, Blatt GJ, Soghomonian JJ. Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in mice. Neuroscience. 2014 Sep 5; 275:238-47.
    View in: PubMed
  2. Oblak A, Gibbs TT, Blatt GJ. Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism Res. 2013 Dec; 6(6):571-83.
    View in: PubMed
  3. Lanoue AC, Blatt GJ, Soghomonian JJ. Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson''s disease. Brain Res. 2013 Sep 19; 1531:37-47.
    View in: PubMed
  4. Blatt GJ. The neuropathology of autism. Scientifica (Cairo). 2012; 2012:703675.
    View in: PubMed
  5. Fatemi SH, Aldinger KA, Ashwood P, Bauman ML, Blaha CD, Blatt GJ, Chauhan A, Chauhan V, Dager SR, Dickson PE, Estes AM, Goldowitz D, Heck DH, Kemper TL, King BH, Martin LA, Millen KJ, Mittleman G, Mosconi MW, Persico AM, Sweeney JA, Webb SJ, Welsh JP. Consensus paper: pathological role of the cerebellum in autism. Cerebellum. 2012 Sep; 11(3):777-807.
    View in: PubMed
  6. Blatt GJ, Fatemi SH. Alterations in GABAergic biomarkers in the autism brain: research findings and clinical implications. Anat Rec (Hoboken). 2011 Oct; 294(10):1646-52.
    View in: PubMed
  7. Lister JP, Blatt GJ, Kemper TL, Tonkiss J, DeBassio WA, Galler JR, Rosene DL. Prenatal protein malnutrition alters the proportion but not numbers of parvalbumin-immunoreactive interneurons in the hippocampus of the adult Sprague-Dawley rat. Nutr Neurosci. 2011 Jul; 14(4):165-78.
    View in: PubMed
  8. Oblak AL, Rosene DL, Kemper TL, Bauman ML, Blatt GJ. Altered posterior cingulate cortical cyctoarchitecture, but normal density of neurons and interneurons in the posterior cingulate cortex and fusiform gyrus in autism. Autism Res. 2011 Jun; 4(3):200-11.
    View in: PubMed
  9. Oblak AL, Gibbs TT, Blatt GJ. Reduced GABAA receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism. Brain Res. 2011 Mar 22; 1380:218-28.
    View in: PubMed
  10. Oblak AL, Gibbs TT, Blatt GJ. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. J Neurochem. 2010 Sep 1; 114(5):1414-23.
    View in: PubMed
  11. Lawrence YA, Kemper TL, Bauman ML, Blatt GJ. Parvalbumin-, calbindin-, and calretinin-immunoreactive hippocampal interneuron density in autism. Acta Neurol Scand. 2010 Feb; 121(2):99-108.
    View in: PubMed
  12. Oblak A, Gibbs TT, Blatt GJ. Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism. Autism Res. 2009 Aug; 2(4):205-19.
    View in: PubMed
  13. Whitney ER, Kemper TL, Rosene DL, Bauman ML, Blatt GJ. Density of cerebellar basket and stellate cells in autism: evidence for a late developmental loss of Purkinje cells. J Neurosci Res. 2009 Aug 1; 87(10):2245-54.
    View in: PubMed
  14. Simms ML, Kemper TL, Timbie CM, Bauman ML, Blatt GJ. The anterior cingulate cortex in autism: heterogeneity of qualitative and quantitative cytoarchitectonic features suggests possible subgroups. Acta Neuropathol. 2009 Nov; 118(5):673-84.
    View in: PubMed
  15. Yip J, Soghomonian JJ, Blatt GJ. Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study. Autism Res. 2009 Feb; 2(1):50-9.
    View in: PubMed
  16. Yip J, Soghomonian JJ, Blatt GJ. Increased GAD67 mRNA expression in cerebellar interneurons in autism: implications for Purkinje cell dysfunction. J Neurosci Res. 2008 Feb 15; 86(3):525-30.
    View in: PubMed
  17. Whitney ER, Kemper TL, Bauman ML, Rosene DL, Blatt GJ. Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k. Cerebellum. 2008; 7(3):406-16.
    View in: PubMed
  18. Whitney ER, Kemper TL, Rosene DL, Bauman ML, Blatt GJ. Calbindin-D28k is a more reliable marker of human Purkinje cells than standard Nissl stains: a stereological experiment. J Neurosci Methods. 2008 Feb 15; 168(1):42-7.
    View in: PubMed
  19. Guptill JT, Booker AB, Gibbs TT, Kemper TL, Bauman ML, Blatt GJ. [3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study. J Autism Dev Disord. 2007 May; 37(5):911-20.
    View in: PubMed
  20. Yip J, Soghomonian JJ, Blatt GJ. Decreased GAD67 mRNA levels in cerebellar Purkinje cells in autism: pathophysiological implications. Acta Neuropathol. 2007 May; 113(5):559-68.
    View in: PubMed
  21. Martchek M, Thevarkunnel S, Bauman M, Blatt G, Kemper T. Lack of evidence of neuropathology in the locus coeruleus in autism. Acta Neuropathol. 2006 May; 111(5):497-9.
    View in: PubMed
  22. Lister JP, Tonkiss J, Blatt GJ, Kemper TL, DeBassio WA, Galler JR, Rosene DL. Asymmetry of neuron numbers in the hippocampal formation of prenatally malnourished and normally nourished rats: a stereological investigation. Hippocampus. 2006; 16(11):946-58.
    View in: PubMed
  23. Blatt GJ. GABAergic cerebellar system in autism: a neuropathological and developmental perspective. Int Rev Neurobiol. 2005; 71:167-78.
    View in: PubMed
  24. Lister JP, Blatt GJ, DeBassio WA, Kemper TL, Tonkiss J, Galler JR, Rosene DL. Effect of prenatal protein malnutrition on numbers of neurons in the principal cell layers of the adult rat hippocampal formation. Hippocampus. 2005; 15(3):393-403.
    View in: PubMed
  25. King RS, DeBassio WA, Kemper TL, Rosene DL, Tonkiss J, Galler JR, Blatt GJ. Effects of prenatal protein malnutrition and acute postnatal stress on granule cell genesis in the fascia dentata of neonatal and juvenile rats. Brain Res Dev Brain Res. 2004 May 19; 150(1):9-15.
    View in: PubMed
  26. Blatt GJ, Pandya DN, Rosene DL. Parcellation of cortical afferents to three distinct sectors in the parahippocampal gyrus of the rhesus monkey: an anatomical and neurophysiological study. J Comp Neurol. 2003 Nov 10; 466(2):161-79.
    View in: PubMed
  27. Fiacco TA, Rosene DL, Galler JR, Blatt GJ. Increased density of hippocampal kainate receptors but normal density of NMDA and AMPA receptors in a rat model of prenatal protein malnutrition. J Comp Neurol. 2003 Feb 17; 456(4):350-60.
    View in: PubMed
  28. King RS, Kemper TL, DeBassio WA, Ramzan M, Blatt GJ, Rosene DL, Galler JR. Birthdates and number of neurons in the serotonergic raphe nuclei in the rat with prenatal protein malnutrition. Nutr Neurosci. 2002 Dec; 5(6):391-7.
    View in: PubMed
  29. Blatt GJ, Fitzgerald CM, Guptill JT, Booker AB, Kemper TL, Bauman ML. Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study. J Autism Dev Disord. 2001 Dec; 31(6):537-43.
    View in: PubMed
  30. Kemper TL, Blatt GJ, Killiany RJ, Moss MB. Neuropathology of progressive cognitive decline in chronically hypertensive rhesus monkeys. Acta Neuropathol. 2001 Feb; 101(2):145-53.
    View in: PubMed
  31. Blatt GJ, Rosene DL. Organization of direct hippocampal efferent projections to the cerebral cortex of the rhesus monkey: projections from CA1, prosubiculum, and subiculum to the temporal lobe. J Comp Neurol. 1998 Mar 2; 392(1):92-114.
    View in: PubMed
  32. Barbas H, Blatt GJ. Topographically specific hippocampal projections target functionally distinct prefrontal areas in the rhesus monkey. Hippocampus. 1995; 5(6):511-33.
    View in: PubMed
  33. Blatt GJ, Chen JC, Rosene DL, Volicer L, Galler JR. Prenatal protein malnutrition effects on the serotonergic system in the hippocampal formation: an immunocytochemical, ligand binding, and neurochemical study. Brain Res Bull. 1994; 34(5):507-18.
    View in: PubMed
  34. Blatt GJ, Eisenman LM. The olivocerebellar projection in normal (+/+), heterozygous weaver (wv/+), and homozygous weaver (wv/wv) mutant mice: comparison of terminal pattern and topographic organization. Exp Brain Res. 1993; 95(2):187-201.
    View in: PubMed
  35. Blatt GJ, Andersen RA, Stoner GR. Visual receptive field organization and cortico-cortical connections of the lateral intraparietal area (area LIP) in the macaque. J Comp Neurol. 1990 Sep 22; 299(4):421-45.
    View in: PubMed
  36. Blatt GJ, Eisenman LM. Regional and topographic organization of the olivocerebellar projection in homozygous staggerer (sg/sg) mutant mice: an anterograde and retrograde tracing study. Neuroscience. 1989; 30(3):703-15.
    View in: PubMed
  37. Blatt GJ, Eisenman LM. Topographic and zonal organization of the olivocerebellar projection in the reeler mutant mouse. J Comp Neurol. 1988 Jan 22; 267(4):603-15.
    View in: PubMed
  38. Blatt GJ, Eisenman LM. A qualitative and quantitative light microscopic study of the inferior olivary complex of normal, reeler, and weaver mutant mice. J Comp Neurol. 1985 Feb 1; 232(1):117-28.
    View in: PubMed
  39. Blatt GJ, Eisenman LM. A qualitative and quantitative light microscopic study of the inferior olivary complex in the adult staggerer mutant mouse. J Neurogenet. 1985 Feb; 2(1):51-66.
    View in: PubMed
  40. Eisenman LM, Sieger DD, Blatt GJ. The olivocerebellar projection to the uvula in the mouse. J Comp Neurol. 1983 Nov 20; 221(1):53-9.
    View in: PubMed
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