Douglas L. Rosene, PhD
Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, University of Rochester



My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Collaborative Research: Unraveling Cerebral Connectivity with Diffusion MRI, Microscopy and Statistical Physics
08/15/2015 - 07/31/2020 (Co-PI)
PI: H. Eugene Stanley, PhD
National Science Foundation
PHY-1505000

Histopathology, Neuroimaging, and Mechanism of Myelin Damage in Aging Monkey Brain
06/15/2016 - 04/30/2018 (PI)
NIH/National Institute on Aging
4R01AG043640-04

Effects of Curcumin on Frontal Circuitry in Aging Monkeys using MRI Connectome
05/01/2016 - 04/30/2018 (PI)
General Hospital Corp d/b/a Massachusett NIH NCCIH
1R21AT008865-01A1

Translational Development of GGF2 as a Stroke Recovery Therapeutic
08/01/2016 - 07/31/2017 (PI)
Acorda Therapeutics, Inc. NIH NINDS
5U01NS076474-02

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
06/01/2016 - 05/31/2017 (PI)
The Brigham and Women's Hospital, Inc. NIH NIA
4R01AG042512-04

Neural Substrates of Diffusion Imaging in Cognitively Aging Rhesus Monkeys
09/15/2013 - 05/31/2016 (PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5R01AG042512-03

Histopathology, Neuroimaging, and Mechanism of Myelin Damage in Aging Monkey Brain
08/01/2013 - 04/30/2016 (PI)
NIH/National Institute on Aging
5R01AG043640-03

The Human Connectome Project (HCP)
09/01/2013 - 08/31/2015 (PI)
Massachusetts General Hospital NIH NIMH
5U01MH093765-05

Quantitative Analysis of Cerebral Cortex in Aging Monkeys
08/01/2008 - 07/31/2015 (Co-PI)
PI: H. Eugene Stanley, PhD
NIH/National Institute on Aging
5R01AG021133-08

Diffusion MRI of Complex White Matter and Connectivity
06/01/2010 - 01/31/2015 (PI)
Massachusetts General Hospital NIH NIMH
5R01MH064044-09

Showing 10 of 19 results. Show All Results



Yr Title Project-Sub Proj Pubs
2017 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 5R01AG043640-05 4
2016 Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St 5U01NS076474-02
2016 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 4R01AG042512-04 7
2016 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 4R01AG043640-04 4
2015 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 3R01AG042512-02S1 7
2014 Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St 1U01NS076474-01A1
2014 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 5R01AG042512-02 7
2014 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 5R01AG043640-02 4
2014 Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain 3R01AG043640-02S1 4
2013 Neural substrates of diffusion imaging in cognitively aging rhesus monkeys 1R01AG042512-01A1 7
Showing 10 of 77 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Shobin E, Bowley MP, Estrada LI, Heyworth NC, Orczykowski ME, Eldridge SA, Calderazzo SM, Mortazavi F, Moore TL, Rosene DL. Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey. Geroscience. 2017 Apr; 39(2):199-220.View Related Profiles. PMID: 28238188; DOI: 10.1007/s11357-017-9965-y;.
  2. Mortazavi F, Oblak AL, Morrison WZ, Schmahmann JD, Stanley HE, Wedeen VJ, Rosene DL. Geometric Navigation of Axons in a Cerebral Pathway: Comparing dMRI with Tract Tracing and Immunohistochemistry. Cereb Cortex. 2017 Feb 16; 1-14.View Related Profiles. PMID: 28203748; DOI: 10.1093/cercor/bhx034;.
  3. Estrada LI, Robinson AA, Amaral AC, Giannaris EL, Heyworth NC, Mortazavi F, Ngwenya LB, Roberts DE, Cabral HJ, Killiany RJ, Rosene DL. Evaluation of Long-Term Cryostorage of Brain Tissue Sections for Quantitative Histochemistry. J Histochem Cytochem. 2017 Mar; 65(3):153-171.View Related Profiles. PMID: 28080173; DOI: 10.1369/0022155416686934;.
  4. Moore TL, Pessina MA, Finklestein SP, Killiany RJ, Bowley B, Benowitz L, Rosene DL. Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey. Restor Neurol Neurosci. 2016 Sep 21; 34(5):827-48.View Related Profiles. PMID: 27497459; DOI: 10.3233/RNN-160661;.
  5. Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, Amaral AC, Ginns EI, Galdzicka M, Bryce CP, Ratner C, Waber DP, Mokler D, Medford G, Champagne FA, Rosene DL, McGaughy JA, Sharp AJ, Galler JR, Akbarian S. DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition. Biol Psychiatry. 2016 Nov 15; 80(10):765-774. PMID: 27184921; DOI: 10.1016/j.biopsych.2016.03.2100;.
  6. Mortazavi F, Wang X, Rosene DL, Rockland KS. White Matter Neurons in Young Adult and Aged Rhesus Monkey. Front Neuroanat. 2016; 10:15.View Related Profiles. PMID: 26941613; PMCID: PMC4761867; DOI: 10.3389/fnana.2016.00015;.
  7. Ngwenya LB, Heyworth NC, Shwe Y, Moore TL, Rosene DL. Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey. Front Syst Neurosci. 2015; 9:102.View Related Profiles. PMID: 26236203; DOI: 10.3389/fnsys.2015.00102;.
  8. Aggleton JP, Wright NF, Rosene DL, Saunders RC. Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex. Cereb Cortex. 2015 Nov; 25(11):4351-73. PMID: 25715284; PMCID: PMC4612443; DOI: 10.1093/cercor/bhv019;.
  9. Fischer LK, McGaughy JA, Bradshaw SE, Weissner WJ, Amaral AC, Rosene DL, Mokler DJ, Fitzmaurice GM, Galler JR. Prenatal protein level impacts homing behavior in Long-Evans rat pups. Nutr Neurosci. 2016 Jun; 19(5):187-95. PMID: 25603489; DOI: 10.1179/1476830515Y.0000000001;.
  10. Amaral AC, Jakovcevski M, McGaughy JA, Calderwood SK, Mokler DJ, Rushmore RJ, Galler JR, Akbarian SA, Rosene DL. Prenatal protein malnutrition decreases KCNJ3 and 2DG activity in rat prefrontal cortex. Neuroscience. 2015 Feb 12; 286:79-86.View Related Profiles. PMID: 25446346; PMCID: PMC4298467; DOI: 10.1016/j.neuroscience.2014.11.005;.
Showing 10 of 144 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 133 publications over 35 distinct years, with a maximum of 9 publications in 2003 and 2005

YearPublications
19801
19811
19822
19831
19841
19853
19861
19872
19884
19891
19902
19935
19943
19953
19963
19975
19983
19997
20004
20023
20039
20048
20059
20066
20072
20087
20095
20103
20116
20128
20133
20143
20153
20163
20173
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

histology
neural imaging
neural receptors
neuroanatomy
neurobiology
neurophysiology
neuropsychology
neurotransmitters
stereology

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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