Keywords
Last Name

Douglas L. Rosene, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentAnatomy & Neurobiology
Address700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Phone(617) 638-4061
Email
ORCID ORCID Icon0000-0001-8719-1441
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
My research interests are the neurobiological basis of learning, memory, and cognitive dysfunction in normal aging as well recovery of function after neurological insults to the brain such as stroke. These studies use multidisciplinary methods including assessment of behavioral and cognitive function, neural imaging of the brain with MRI, and analysis of neuronal function and organization with neurophysiological, neurohistochemical, neuropharmacological and neuroanatomical methods. The majority of studies utilize non-human primate models of aging, stroke, brain injury and cerebrovascular disease as well as a rat model of prenatal malnutrition.

 Self-Described Keywords
  • histology
  • neural imaging
  • neural receptors
  • neuroanatomy
  • neurobiology
  • neurophysiology
  • neuropsychology
  • neurotransmitters
  • stereology
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Shobin E, Bowley MP, Estrada LI, Heyworth NC, Orczykowski ME, Eldridge SA, Calderazzo SM, Mortazavi F, Moore TL, Rosene DL. Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey. Geroscience. 2017 Feb 25. PMID: 28238188.
    View in: PubMed
  2. Mortazavi F, Oblak AL, Morrison WZ, Schmahmann JD, Stanley HE, Wedeen VJ, Rosene DL. Geometric Navigation of Axons in a Cerebral Pathway: Comparing dMRI with Tract Tracing and Immunohistochemistry. Cereb Cortex. 2017 Feb 16; 1-14. PMID: 28203748.
    View in: PubMed
  3. Estrada LI, Robinson AA, Amaral AC, Giannaris EL, Heyworth NC, Mortazavi F, Ngwenya LB, Roberts DE, Cabral HJ, Killiany RJ, Rosene DL. Evaluation of Long-Term Cryostorage of Brain Tissue Sections for Quantitative Histochemistry. J Histochem Cytochem. 2017 Mar; 65(3):153-171. PMID: 28080173.
    View in: PubMed
  4. Moore TL, Pessina MA, Finklestein SP, Killiany RJ, Bowley B, Benowitz L, Rosene DL. Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey. Restor Neurol Neurosci. 2016 Sep 21; 34(5):827-48. PMID: 27497459.
    View in: PubMed
  5. Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, Amaral AC, Ginns EI, Galdzicka M, Bryce CP, Ratner C, Waber DP, Mokler D, Medford G, Champagne FA, Rosene DL, McGaughy JA, Sharp AJ, Galler JR, Akbarian S. DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition. Biol Psychiatry. 2016 Nov 15; 80(10):765-774. PMID: 27184921.
    View in: PubMed
  6. Mortazavi F, Wang X, Rosene DL, Rockland KS. White Matter Neurons in Young Adult and Aged Rhesus Monkey. Front Neuroanat. 2016; 10:15. PMID: 26941613.
    View in: PubMed
  7. Ngwenya LB, Heyworth NC, Shwe Y, Moore TL, Rosene DL. Age-related changes in dentate gyrus cell numbers, neurogenesis, and associations with cognitive impairments in the rhesus monkey. Front Syst Neurosci. 2015; 9:102. PMID: 26236203.
    View in: PubMed
  8. Aggleton JP, Wright NF, Rosene DL, Saunders RC. Complementary Patterns of Direct Amygdala and Hippocampal Projections to the Macaque Prefrontal Cortex. Cereb Cortex. 2015 Nov; 25(11):4351-73. PMID: 25715284.
    View in: PubMed
  9. Fischer LK, McGaughy JA, Bradshaw SE, Weissner WJ, Amaral AC, Rosene DL, Mokler DJ, Fitzmaurice GM, Galler JR. Prenatal protein level impacts homing behavior in Long-Evans rat pups. Nutr Neurosci. 2016 Jun; 19(5):187-95. PMID: 25603489.
    View in: PubMed
  10. Amaral AC, Jakovcevski M, McGaughy JA, Calderwood SK, Mokler DJ, Rushmore RJ, Galler JR, Akbarian SA, Rosene DL. Prenatal protein malnutrition decreases KCNJ3 and 2DG activity in rat prefrontal cortex. Neuroscience. 2015 Feb 12; 286:79-86. PMID: 25446346.
    View in: PubMed
  11. McGaughy JA, Amaral AC, Rushmore RJ, Mokler DJ, Morgane PJ, Rosene DL, Galler JR. Prenatal malnutrition leads to deficits in attentional set shifting and decreases metabolic activity in prefrontal subregions that control executive function. Dev Neurosci. 2014; 36(6):532-41. PMID: 25342495.
    View in: PubMed
  12. Comin CH, Santos JR, Corradini D, Morrison W, Curme C, Rosene DL, Gabrielli A, Costa Lda F, Stanley HE. Statistical physics approach to quantifying differences in myelinated nerve fibers. Sci Rep. 2014; 4:4511. PMID: 24676146.
    View in: PubMed
  13. Koo BB, Oblak AL, Zhao Y, Farris CW, Bowley B, Rosene DL, Killiany RJ. Hippocampal network connections account for differences in memory performance in the middle-aged rhesus monkey. Hippocampus. 2013 Dec; 23(12):1179-88. PMID: 23780752.
    View in: PubMed
  14. Moore TL, Pessina MA, Finklestein SP, Kramer BC, Killiany RJ, Rosene DL. Recovery of fine motor performance after ischemic damage to motor cortex is facilitated by cell therapy in the rhesus monkey. Somatosens Mot Res. 2013 Dec; 30(4):185-96. PMID: 23758412.
    View in: PubMed
  15. Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013 Jan 30; 33(5):1927-39. PMID: 23365232.
    View in: PubMed
  16. Moore TL, Schettler SP, Killiany RJ, Rosene DL, Moss MB. Impairment in delayed nonmatching to sample following lesions of dorsal prefrontal cortex. Behav Neurosci. 2012 Dec; 126(6):772-80. PMID: 23088539.
    View in: PubMed
  17. Giannaris EL, Rosene DL. A stereological study of the numbers of neurons and glia in the primary visual cortex across the lifespan of male and female rhesus monkeys. J Comp Neurol. 2012 Oct 15; 520(15):3492-508. PMID: 22430145.
    View in: PubMed
  18. Amatrudo JM, Weaver CM, Crimins JL, Hof PR, Rosene DL, Luebke JI. Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices. J Neurosci. 2012 Oct 3; 32(40):13644-60. PMID: 23035077.
    View in: PubMed
  19. Wedeen VJ, Rosene DL, Wang R, Dai G, Mortazavi F, Hagmann P, Kaas JH, Tseng WY. Response to comment on "the geometric structure of the brain fiber pathways". Science. 2012 Sep 28; 337(6102):1605. PMID: 23019633.
    View in: PubMed
  20. Roberts DE, Killiany RJ, Rosene DL. Neuron numbers in the hypothalamus of the normal aging rhesus monkey: stability across the adult lifespan and between the sexes. J Comp Neurol. 2012 Apr 15; 520(6):1181-97. PMID: 21935936.
    View in: PubMed
  21. Wedeen VJ, Rosene DL, Wang R, Dai G, Mortazavi F, Hagmann P, Kaas JH, Tseng WY. The geometric structure of the brain fiber pathways. Science. 2012 Mar 30; 335(6076):1628-34. PMID: 22461612.
    View in: PubMed
  22. Zhdanova IV, Masuda K, Bozhokin SV, Rosene DL, González-Martínez J, Schettler S, Samorodnitsky E. Familial circadian rhythm disorder in the diurnal primate, Macaca mulatta. PLoS One. 2012; 7(3):e33327. PMID: 22413014.
    View in: PubMed
  23. Macri SC, Bailey CC, de Oca NM, Silva NA, Rosene DL, Mansfield KG, Miller AD. Immunophenotypic alterations in resident immune cells and myocardial fibrosis in the aging rhesus macaque (Macaca mulatta) heart. Toxicol Pathol. 2012 Jun; 40(4):637-46. PMID: 22328408.
    View in: PubMed
  24. Kohama SG, Rosene DL, Sherman LS. Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline. Age (Dordr). 2012 Oct; 34(5):1093-110. PMID: 22203458.
    View in: PubMed
  25. King GD, Rosene DL, Abraham CR. Promoter methylation and age-related downregulation of Klotho in rhesus monkey. Age (Dordr). 2012 Dec; 34(6):1405-19. PMID: 21922250.
    View in: PubMed
  26. Lister JP, Blatt GJ, Kemper TL, Tonkiss J, DeBassio WA, Galler JR, Rosene DL. Prenatal protein malnutrition alters the proportion but not numbers of parvalbumin-immunoreactive interneurons in the hippocampus of the adult Sprague-Dawley rat. Nutr Neurosci. 2011 Jul; 14(4):165-78. PMID: 21902887.
    View in: PubMed
  27. Moore TL, Killiany RJ, Pessina MA, Moss MB, Finklestein SP, Rosene DL. Recovery from ischemia in the middle-aged brain: a nonhuman primate model. Neurobiol Aging. 2012 Mar; 33(3):619.e9-619.e24. PMID: 21458887.
    View in: PubMed
  28. Zhdanova IV, Masuda K, Quasarano-Kourkoulis C, Rosene DL, Killiany RJ, Wang S. Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta. J Biol Rhythms. 2011 Apr; 26(2):149-59. PMID: 21454295.
    View in: PubMed
  29. Oblak AL, Rosene DL, Kemper TL, Bauman ML, Blatt GJ. Altered posterior cingulate cortical cyctoarchitecture, but normal density of neurons and interneurons in the posterior cingulate cortex and fusiform gyrus in autism. Autism Res. 2011 Jun; 4(3):200-11. PMID: 21360830.
    View in: PubMed
  30. Koo BB, Schettler SP, Murray DE, Lee JM, Killiany RJ, Rosene DL, Kim DS, Ronen I. Age-related effects on cortical thickness patterns of the Rhesus monkey brain. Neurobiol Aging. 2012 Jan; 33(1):200.e23-31. PMID: 20801549.
    View in: PubMed
  31. Bowley MP, Cabral H, Rosene DL, Peters A. Age changes in myelinated nerve fibers of the cingulate bundle and corpus callosum in the rhesus monkey. J Comp Neurol. 2010 Aug 1; 518(15):3046-64. PMID: 20533359.
    View in: PubMed
  32. Moore TL, Killiany RJ, Pessina MA, Moss MB, Rosene DL. Assessment of motor function of the hand in aged rhesus monkeys. Somatosens Mot Res. 2010; 27(3):121-30. PMID: 20653499.
    View in: PubMed
  33. Whitney ER, Kemper TL, Rosene DL, Bauman ML, Blatt GJ. Density of cerebellar basket and stellate cells in autism: evidence for a late developmental loss of Purkinje cells. J Neurosci Res. 2009 Aug 1; 87(10):2245-54. PMID: 19301429.
    View in: PubMed
  34. Makris N, Kennedy DN, Boriel DL, Rosene DL. Methods of MRI-based structural imaging in the aging monkey. Methods. 2010 Mar; 50(3):166-77. PMID: 19577648.
    View in: PubMed
  35. Ronen I, Fan X, Schettler S, Jain S, Murray D, Kim DS, Killiany R, Rosene D. Regional age-related effects in the monkey brain measured with 1H magnetic resonance spectroscopy. Neurobiol Aging. 2011 Jun; 32(6):1138-48. PMID: 19560839.
    View in: PubMed
  36. Moore TL, Schettler SP, Killiany RJ, Rosene DL, Moss MB. Effects on executive function following damage to the prefrontal cortex in the rhesus monkey (Macaca mulatta). Behav Neurosci. 2009 Apr; 123(2):231-41. PMID: 19331446.
    View in: PubMed
  37. Wedeen V, Wang R, Schmahmann JD, Takahashi E, Kaas JH, Hagmann P:, Tseng WYI, Rosene DL, Dai G. Diffusion Spectrum MRI in Three Mammals: Rat, Monkey and Human. Frontiers in Neuroscience. 2009; 3(1):74 - 77.
  38. Cruz L, Roe DL, Urbanc B, Inglis A, Stanley HE, Rosene DL. Age-related reduction in microcolumnar structure correlates with cognitive decline in ventral but not dorsal area 46 of the rhesus monkey. Neuroscience. 2009 Feb 18; 158(4):1509-20. PMID: 19105976.
    View in: PubMed
  39. Inglis A, Cruz L, Roe DL, Stanley HE, Rosene DL, Urbanc B. Automated identification of neurons and their locations. J Microsc. 2008 Jun; 230(Pt 3):339-52. PMID: 18503659.
    View in: PubMed
  40. Wisco JJ, Rosene DL, Killiany RJ, Moss MB, Warfield SK, Egorova S, Wu Y, Liptak Z, Warner J, Guttmann CR. A rhesus monkey reference label atlas for template driven segmentation. J Med Primatol. 2008 Oct; 37(5):250-60. PMID: 18466282.
    View in: PubMed
  41. Cruz L, Urbanc B, Inglis A, Rosene DL, Stanley HE. Generating a model of the three-dimensional spatial distribution of neurons using density maps. Neuroimage. 2008 Apr 15; 40(3):1105-15. PMID: 18291677.
    View in: PubMed
  42. Ngwenya LB, Rosene DL, Peters A. An ultrastructural characterization of the newly generated cells in the adult monkey dentate gyrus. Hippocampus. 2008; 18(2):210-20. PMID: 18058825.
    View in: PubMed
  43. Whitney ER, Kemper TL, Bauman ML, Rosene DL, Blatt GJ. Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k. Cerebellum. 2008; 7(3):406-16. PMID: 18587625.
    View in: PubMed
  44. Duce JA, Podvin S, Hollander W, Kipling D, Rosene DL, Abraham CR. Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia. 2008 Jan 1; 56(1):106-17. PMID: 17963266.
    View in: PubMed
  45. Whitney ER, Kemper TL, Rosene DL, Bauman ML, Blatt GJ. Calbindin-D28k is a more reliable marker of human Purkinje cells than standard Nissl stains: a stereological experiment. J Neurosci Methods. 2008 Feb 15; 168(1):42-7. PMID: 17961663.
    View in: PubMed
  46. Wisco JJ, Killiany RJ, Guttmann CR, Warfield SK, Moss MB, Rosene DL. An MRI study of age-related white and gray matter volume changes in the rhesus monkey. Neurobiol Aging. 2008 Oct; 29(10):1563-75. PMID: 17459528.
    View in: PubMed
  47. Nesathurai S, Andrew Graham W, Edell DJ, Rosene DL, Mansfield K, Sehgal P, Magill D, Sledge JB. Electromyographic telemetry in the development of humane primate model of spinal cord injury. J Med Primatol. 2006 Dec; 35(6):397-400. PMID: 17214669.
    View in: PubMed
  48. Nesathurai S, Graham WA, Mansfield K, Magill D, Sehgal P, Westmoreland SV, Prusty S, Rosene DL, Sledge JB. Model of traumatic spinal cord injury in Macaca fascicularis: similarity of experimental lesions created by epidural catheter to human spinal cord injury. J Med Primatol. 2006 Dec; 35(6):401-4. PMID: 17214670.
    View in: PubMed
  49. Ngwenya LB, Peters A, Rosene DL. Maturational sequence of newly generated neurons in the dentate gyrus of the young adult rhesus monkey. J Comp Neurol. 2006 Sep 10; 498(2):204-16. PMID: 16856135.
    View in: PubMed
  50. Makris N, Papadimitriou GM, van der Kouwe A, Kennedy DN, Hodge SM, Dale AM, Benner T, Wald LL, Wu O, Tuch DS, Caviness VS, Moore TL, Killiany RJ, Moss MB, Rosene DL. Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI study. Neurobiol Aging. 2007 Oct; 28(10):1556-67. PMID: 16962214.
    View in: PubMed
  51. Hinman JD, Peters A, Cabral H, Rosene DL, Hollander W, Rasband MN, Abraham CR. Age-related molecular reorganization at the node of Ranvier. J Comp Neurol. 2006 Apr 1; 495(4):351-62. PMID: 16485288.
    View in: PubMed
  52. Lister JP, Tonkiss J, Blatt GJ, Kemper TL, DeBassio WA, Galler JR, Rosene DL. Asymmetry of neuron numbers in the hippocampal formation of prenatally malnourished and normally nourished rats: a stereological investigation. Hippocampus. 2006; 16(11):946-58. PMID: 16983649.
    View in: PubMed
  53. Moore TL, Killiany RJ, Herndon JG, Rosene DL, Moss MB. Executive system dysfunction occurs as early as middle-age in the rhesus monkey. Neurobiol Aging. 2006 Oct; 27(10):1484-93. PMID: 16183172.
    View in: PubMed
  54. Moore TL, Killiany RJ, Herndon JG, Rosene DL, Moss MB. A non-human primate test of abstraction and set shifting: an automated adaptation of the Wisconsin Card Sorting Test. J Neurosci Methods. 2005 Aug 15; 146(2):165-73. PMID: 16054506.
    View in: PubMed
  55. Ngwenya LB, Peters A, Rosene DL. Light and electron microscopic immunohistochemical detection of bromodeoxyuridine-labeled cells in the brain: different fixation and processing protocols. J Histochem Cytochem. 2005 Jul; 53(7):821-32. PMID: 15995140.
    View in: PubMed
  56. Chang YM, Rosene DL, Killiany RJ, Mangiamele LA, Luebke JI. Increased action potential firing rates of layer 2/3 pyramidal cells in the prefrontal cortex are significantly related to cognitive performance in aged monkeys. Cereb Cortex. 2005 Apr; 15(4):409-18. PMID: 15749985.
    View in: PubMed
  57. Cruz L, Buldyrev SV, Peng S, Roe DL, Urbanc B, Stanley HE, Rosene DL. A statistically based density map method for identification and quantification of regional differences in microcolumnarity in the monkey brain. J Neurosci Methods. 2005 Feb 15; 141(2):321-32. PMID: 15661314.
    View in: PubMed
  58. Lacreuse A, Kim CB, Rosene DL, Killiany RJ, Moss MB, Moore TL, Chennareddi L, Herndon JG. Sex, age, and training modulate spatial memory in the rhesus monkey (Macaca mulatta). Behav Neurosci. 2005 Feb; 119(1):118-26. PMID: 15727518.
    View in: PubMed
  59. Moore TL, Schettler SP, Killiany RJ, Herndon JG, Luebke JI, Moss MB, Rosene DL. Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex. Behav Brain Res. 2005 May 28; 160(2):208-21. PMID: 15863218.
    View in: PubMed
  60. Lister JP, Blatt GJ, DeBassio WA, Kemper TL, Tonkiss J, Galler JR, Rosene DL. Effect of prenatal protein malnutrition on numbers of neurons in the principal cell layers of the adult rat hippocampal formation. Hippocampus. 2005; 15(3):393-403. PMID: 15669101.
    View in: PubMed
  61. Chen C, Duce Ja, Hollander W, Kipling D, Rosene DL, Abraham CR. Gene expression profiles in aging rhesus monkey brain. Journal of Neurochemistry. 2005; 94:24-24, Suppl. 1.
  62. Cruz L, Roe DL, Urbanc B, Cabral H, Stanley HE, Rosene DL. Age-related reduction in microcolumnar structure in area 46 of the rhesus monkey correlates with behavioral decline. Proc Natl Acad Sci U S A. 2004 Nov 9; 101(45):15846-51. PMID: 15520373.
    View in: PubMed
  63. Schmahmann JD, Rosene DL, Pandya DN. Motor projections to the basis pontis in rhesus monkey. J Comp Neurol. 2004 Oct 18; 478(3):248-68. PMID: 15368534.
    View in: PubMed
  64. Rosene DL, Lister JP, Schwagerl AL, Tonkiss J, McCormick CM, Galler JR. Prenatal protein malnutrition in rats alters the c-Fos response of neurons in the anterior cingulate and medial prefrontal region to behavioral stress. Nutr Neurosci. 2004 Oct-Dec; 7(5-6):281-9. PMID: 15682924.
    View in: PubMed
  65. King RS, DeBassio WA, Kemper TL, Rosene DL, Tonkiss J, Galler JR, Blatt GJ. Effects of prenatal protein malnutrition and acute postnatal stress on granule cell genesis in the fascia dentata of neonatal and juvenile rats. Brain Res Dev Brain Res. 2004 May 19; 150(1):9-15. PMID: 15126033.
    View in: PubMed
  66. Schmahmann JD, Rosene DL, Pandya DN. Ataxia after pontine stroke: insights from pontocerebellar fibers in monkey. Ann Neurol. 2004 Apr; 55(4):585-9. PMID: 15048900.
    View in: PubMed
  67. Fukumoto H, Rosene DL, Moss MB, Raju S, Hyman BT, Irizarry MC. Beta-secretase activity increases with aging in human, monkey, and mouse brain. Am J Pathol. 2004 Feb; 164(2):719-25. PMID: 14742275.
    View in: PubMed
  68. Luebke JI, Chang YM, Moore TL, Rosene DL. Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex. Neuroscience. 2004; 125(1):277-88. PMID: 15051166.
    View in: PubMed
  69. Lacreuse A, Kim CB, Rosene DL, Killiany RJ, Moss MB, Moore TL, Herndon JG . Sex and age differences in spatial memory in the rhesus monkey. Hormones and Behavior. 2004; 46(1):94-94.
  70. Blatt GJ, Pandya DN, Rosene DL. Parcellation of cortical afferents to three distinct sectors in the parahippocampal gyrus of the rhesus monkey: an anatomical and neurophysiological study. J Comp Neurol. 2003 Nov 10; 466(2):161-79. PMID: 14528446.
    View in: PubMed
  71. O'Brien S, Rosene DL, Luebke JI. GABAA receptor-mediated neurotransmission in the dentate gyrus of the rhesus monkey: comparison with the rat. Synapse. 2003 Sep 15; 49(4):287-9. PMID: 12827648.
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  72. Peters A, Rosene DL. In aging, is it gray or white? J Comp Neurol. 2003 Jul 21; 462(2):139-43. PMID: 12794738.
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  73. Luebke JI, Rosene DL. Aging alters dendritic morphology, input resistance, and inhibitory signaling in dentate granule cells of the rhesus monkey. J Comp Neurol. 2003 Jun 9; 460(4):573-84. PMID: 12717715.
    View in: PubMed
  74. McDannold N, Moss M, Killiany R, Rosene DL, King RL, Jolesz FA, Hynynen K. MRI-guided focused ultrasound surgery in the brain: tests in a primate model. Magn Reson Med. 2003 Jun; 49(6):1188-91. PMID: 12768598.
    View in: PubMed
  75. Fiacco TA, Rosene DL, Galler JR, Blatt GJ. Increased density of hippocampal kainate receptors but normal density of NMDA and AMPA receptors in a rat model of prenatal protein malnutrition. J Comp Neurol. 2003 Feb 17; 456(4):350-60. PMID: 12532407.
    View in: PubMed
  76. Herndon J, Lacreuse A, Moore T, Killiany R, Rosene D, Moss M. Overview of cognitive aging research in the rhesus monkey. Experimental Gerontology. 2003; 38(1-2):218-219.
  77. Moore TL, Killiany RJ, Rosene DL, Prusty S, Hollander W, Moss MB. Hypertension-induced changes in monoamine receptors in the prefrontal cortex of rhesus monkeys. Neuroscience. 2003; 120(1):177-89. PMID: 12849751.
    View in: PubMed
  78. Moore TL, Killiany RJ, Herndon JG, Rosene DL, Moss MB. Impairment in abstraction and set shifting in aged rhesus monkeys. Neurobiol Aging. 2003 Jan-Feb; 24(1):125-34. PMID: 12493558.
    View in: PubMed
  79. King RS, Kemper TL, DeBassio WA, Ramzan M, Blatt GJ, Rosene DL, Galler JR. Birthdates and number of neurons in the serotonergic raphe nuclei in the rat with prenatal protein malnutrition. Nutr Neurosci. 2002 Dec; 5(6):391-7. PMID: 12509068.
    View in: PubMed
  80. Moore TL, Killiany RJ, Rosene DL, Prusty S, Hollander W, Moss MB. Impairment of executive function induced by hypertension in the rhesus monkey (Macaca mulatta). Behav Neurosci. 2002 Jun; 116(3):387-96. PMID: 12049319.
    View in: PubMed
  81. Zhdanova IV, Geiger DA, Schwagerl AL, Leclair OU, Killiany R, Taylor JA, Rosene DL, Moss MB, Madras BK. Melatonin promotes sleep in three species of diurnal nonhuman primates. Physiol Behav. 2002 Apr 1; 75(4):523-9. PMID: 12062316.
    View in: PubMed
  82. Bartolák-Suki E, Sipe JD, Fine RE, Rosene DL, Moss MB. Serum amyloid A is present in the capillaries and microinfarcts of hypertensive monkey brain: an immunohistochemical study. Amyloid. 2000 Jun; 7(2):111-7. PMID: 10842713.
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  83. Sloane JA, Hollander W, Rosene DL, Moss MB, Kemper T, Abraham CR. Astrocytic hypertrophy and altered GFAP degradation with age in subcortical white matter of the rhesus monkey. Brain Res. 2000 Apr 17; 862(1-2):1-10. PMID: 10799662.
    View in: PubMed
  84. Tonkiss J, Shultz PL, Shumsky JS, Fiacco TT, Vincitore M, Rosene DL, Galler JR. Chlordiazepoxide-induced spatial learning deficits: dose-dependent differences following prenatal malnutrition. Pharmacol Biochem Behav. 2000 Jan 1; 65(1):105-16. PMID: 10638643.
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  85. Killiany RJ, Moss MB, Rosene DL, Herndon JG. Recognition memory function in early senescent rhesus monkeys. Psychobiology. 2000; 28(1):45-56.
  86. Herndon JG, Lacreuse A, Ladinsky E, Killiany RJ, Rosene DL, Moss MB. Age-related decline in DHEAS is not related to cognitive impairment in aged monkeys. Neuroreport. 1999 Nov 26; 10(17):3507-11. PMID: 10619634.
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  87. Lacreuse A, Herndon JG, Killiany RJ, Rosene DL, Moss MB. Spatial cognition in rhesus monkeys: male superiority declines with age. Horm Behav. 1999 Aug; 36(1):70-6. PMID: 10433888.
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  88. Sloane JA, Hollander W, Moss MB, Rosene DL, Abraham CR. Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol Aging. 1999 Jul-Aug; 20(4):395-405. PMID: 10604432.
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  89. Beason-Held LL, Rosene DL, Killiany RJ, Moss MB. Hippocampal formation lesions produce memory impairment in the rhesus monkey. Hippocampus. 1999; 9(5):562-74. PMID: 10560927.
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  90. Rosene DL, Nicholson TJ. Some Neurotransmitter receptor changes in the hippocampus and cerebral cortex in normal aging. Cerebral Cortex: Neurodegenerative and Age-related Changes in Cerebral Cortex. Jones, EG, Peters, A and Morrison, JH (Eds). Kluwer Academic/Plenum. New York. 1999; 14:111-128.
  91. Cermak JM, Blusztajn JK, Meck WH, Williams CL, Fitzgerald CM, Rosene DL, Loy R. Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus. Dev Neurosci. 1999; 21(2):94-104. PMID: 10449981.
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  92. King RS, Kemper TL, DeBassio WA, Blatt GJ, Ramzan M, Rosene DL, Galler JR. Effect of Prenatal Protein Malnutrition on Birthdates and Number of Neurons in the Rat Locus Coeruleus. Nutr Neurosci. 1999; 2(4):267-76. PMID: 27415578.
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  93. Peters A, Morrison JH, Rosene DL, Hyman BT. Feature article: are neurons lost from the primate cerebral cortex during normal aging? Cereb Cortex. 1998 Jun; 8(4):295-300. PMID: 9651126.
    View in: PubMed
  94. Blatt GJ, Rosene DL. Organization of direct hippocampal efferent projections to the cerebral cortex of the rhesus monkey: projections from CA1, prosubiculum, and subiculum to the temporal lobe. J Comp Neurol. 1998 Mar 2; 392(1):92-114. PMID: 9482235.
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  95. Turiak G, Rosene DL, Volicer L. Determination of thiobarbituric acid reactive products formed from deoxyribose in biological samples. Neuroscience Research Communications. 1998; 23:151-158.
  96. Sloane JA, Pietropaolo MF, Rosene DL, Moss MB, Peters A, Kemper T, Abraham CR. Lack of correlation between plaque burden and cognition in the aged monkey. Acta Neuropathol. 1997 Nov; 94(5):471-8. PMID: 9386780.
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  97. St John JL, Rosene DL, Luebke JI. Morphology and electrophysiology of dentate granule cells in the rhesus monkey: comparison with the rat. J Comp Neurol. 1997 Oct 13; 387(1):136-47. PMID: 9331177.
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  98. Herndon JG, Moss MB, Rosene DL, Killiany RJ. Patterns of cognitive decline in aged rhesus monkeys. Behav Brain Res. 1997 Aug; 87(1):25-34. PMID: 9331471.
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  99. Kemper TL, Moss MB, Rosene DL, Killiany RJ. Age-related neuronal loss in the nucleus centralis superior of the rhesus monkey. Acta Neuropathol. 1997 Aug; 94(2):124-30. PMID: 9255386.
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  100. Moss MB, Killiany RJ, Lai ZC, Rosene DL, Herndon JG. Recognition memory span in rhesus monkeys of advanced age. Neurobiol Aging. 1997 Jan-Feb; 18(1):13-9. PMID: 8983028.
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  101. Peters A, Rosene DL, Moss MB, Kemper TL, Abraham CR, Tigges J, Albert MS. Neurobiological bases of age-related cognitive decline in the rhesus monkey. J Neuropathol Exp Neurol. 1996 Aug; 55(8):861-74. PMID: 8759775.
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  102. Tavares A, Handy DE, Bogdanova NN, Rosene DL, Gavras H. Localization of alpha 2A- and alpha 2B-adrenergic receptor subtypes in brain. Hypertension. 1996 Mar; 27(3 Pt 1):449-55. PMID: 8698452.
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  103. Tigges J, Herndon JG, Rosene DL. Preservation into old age of synaptic number and size in the supragranular layer of the dentate gyrus in rhesus monkeys. Acta Anat (Basel). 1996; 157(1):63-72. PMID: 9096743.
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  104. Lai ZC, Moss MB, Killiany RJ, Rosene DL, Herndon JG. Executive system dysfunction in the aged monkey: spatial and object reversal learning. Neurobiol Aging. 1995 Nov-Dec; 16(6):947-54. PMID: 8622786.
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  105. Poduri A, Beason-Held LL, Moss MB, Rosene DL, Hyman BT. CA3 neuronal degeneration follows chronic entorhinal cortex lesions. Neurosci Lett. 1995 Sep 1; 197(1):1-4. PMID: 8545043.
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  106. Tigges J, Herndon JG, Rosene DL. Mild age-related changes in the dentate gyrus of adult rhesus monkeys. Acta Anat (Basel). 1995; 153(1):39-48. PMID: 8560958.
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  107. Pandya DN, Rosene DL, Doolittle AM. Corticothalamic connections of auditory-related areas of the temporal lobe in the rhesus monkey. J Comp Neurol. 1994 Jul 15; 345(3):447-71. PMID: 7929912.
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  108. Hyman BT, Reiter J, Moss M, Rosene D, Pandya D. Extracellular signal-regulated kinase (MAP kinase) immunoreactivity in the rhesus monkey brain. Neurosci Lett. 1994 Jan 17; 166(1):113-6. PMID: 8190351.
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  109. Blatt GJ, Chen JC, Rosene DL, Volicer L, Galler JR. Prenatal protein malnutrition effects on the serotonergic system in the hippocampal formation: an immunocytochemical, ligand binding, and neurochemical study. Brain Res Bull. 1994; 34(5):507-18. PMID: 8082044.
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  110. Rosene DL. Comparing age-related changes in the basal forebrain and hippocampus of the rhesus monkey. Neurobiol Aging. 1993 Nov-Dec; 14(6):669-70. PMID: 8295681.
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  111. Rhodes KJ, Meiners KA, Rosene DL. A novel hinge system and incubation chamber for emulsion-coated coverslip autoradiography. J Histochem Cytochem. 1993 Sep; 41(9):1419-27. PMID: 8354882.
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  112. Hollander W, Prusty S, Kemper T, Rosene DL, Moss MB. The effects of hypertension on cerebral atherosclerosis in the cynomolgus monkey. Stroke. 1993 Aug; 24(8):1218-26; discussion 1226-7. PMID: 8342199.
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  113. Pandya DN, Rosene DL. Laminar termination patterns of thalamic, callosal, and association afferents in the primary auditory area of the rhesus monkey. Exp Neurol. 1993 Feb; 119(2):220-34. PMID: 7679356.
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  114. Moss MB, Rosene DL. Therapeutic effects of nimodipine on age-related memory dysfunction in the monkey. Drugs in Development. 1993; 2:249-261.
  115. Demeter S, Rosene DL, Van Hoesen GW. Fields of origin and pathways of the interhemispheric commissures in the temporal lobe of macaques. J Comp Neurol. 1990 Dec 1; 302(1):29-53. PMID: 2086614.
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  116. Rosene DL, Rhodes KJ. Cryoprotection and freezing methods that control ice crystal artifact in frozen sections from fixed and unfixed blocks of monkey and human brain tissue. Methods in Neuroscience: Quantitative and Qualitative Microscopy, PM Conn (Ed.). Academic Press. New York. 1990; 3:360-385.
  117. Demeter S, Rosene DL, Van Hoesen GW. Commissural connections and symmetry of degeneration in Alzheimer's disease. Arch Neurol. 1989 Jul; 46(7):723-4. PMID: 2742541.
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  118. Hreib KK, Rosene DL, Moss MB. Basal forebrain efferents to the medial dorsal thalamic nucleus in the rhesus monkey. J Comp Neurol. 1988 Nov 15; 277(3):365-90. PMID: 2461974.
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  119. Moss MB, Rosene DL, Peters A. Effects of aging on visual recognition memory in the rhesus monkey. Neurobiol Aging. 1988 Sep-Dec; 9(5-6):495-502. PMID: 3062461.
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  120. Saunders RC, Rosene DL, Van Hoesen GW. Comparison of the efferents of the amygdala and the hippocampal formation in the rhesus monkey: II. Reciprocal and non-reciprocal connections. J Comp Neurol. 1988 May 8; 271(2):185-207. PMID: 2454247.
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  121. Saunders RC, Rosene DL. A comparison of the efferents of the amygdala and the hippocampal formation in the rhesus monkey: I. Convergence in the entorhinal, prorhinal, and perirhinal cortices. J Comp Neurol. 1988 May 8; 271(2):153-84. PMID: 2454246.
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  122. Vogt BA, Pandya DN, Rosene DL. Cingulate cortex of the rhesus monkey: I. Cytoarchitecture and thalamic afferents. J Comp Neurol. 1987 Aug 8; 262(2):256-70. PMID: 3624554.
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  123. Rosene DL, Van Hoesen GW. The hippocampal formation of the primate brain: A review of some comparative aspects of cytoarchitecture and connections. Cerebral Cortex, EG Jones and A Peters (Eds.). Plenum Press. New York. 1987; 6:345-456.
  124. Rosene DL, Roy NJ, Davis BJ. A cryoprotection method that facilitates cutting frozen sections of whole monkey brains for histological and histochemical processing without freezing artifact. J Histochem Cytochem. 1986 Oct; 34(10):1301-15. PMID: 3745909.
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  125. Demeter S, Rosene DL, Van Hoesen GW. Interhemispheric pathways of the hippocampal formation, presubiculum, and entorhinal and posterior parahippocampal cortices in the rhesus monkey: the structure and organization of the hippocampal commissures. J Comp Neurol. 1985 Mar 1; 233(1):30-47. PMID: 3980771.
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  126. Pandya DN, Rosene DL. Some observations on the trajectories and topography of commissural fibers. Epilepsy and the Corpus Callosum, A.G. Reeves (Ed.). Plenum Press. New York. 1985; 21 – 39.
  127. Moss MB, Rosene DL. Neural transplantation: A panacea?. Neurobiology of Aging. 1985; 6:168-169.
  128. Moss MB, Rosene DL. A perfusion-fixation procedure for the concurrent demonstration of Timm's, horseradish peroxidase (HRP), and acethycholinesterase (AChE) histochemistry. J Histochem Cytochem. 1984 Oct; 32(10):1113-6. PMID: 6481150.
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  129. Kosel KC, Van Hoesen GW, Rosene DL. A direct projection from the perirhinal cortex (area 35) to the subiculum in the rat. Brain Res. 1983 Jun 20; 269(2):347-51. PMID: 6883086.
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  130. Kosel KC, Van Hoesen GW, Rosene DL. Non-hippocampal cortical projections from the entorhinal cortex in the rat and rhesus monkey. Brain Res. 1982 Jul 29; 244(2):201-13. PMID: 7116171.
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  131. Davis BJ, Rosene DL, Youngs WM, Macrides F. Digital counter tallys number of tissue sections cut and recycles at selectable intervals. Stain Technol. 1982 May; 57(3):131-6. PMID: 7135427.
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  132. Vogt BA, Rosene DL, Peters A. Synaptic termination of thalamic and callosal afferents in cingulate cortex of the rat. J Comp Neurol. 1981 Sep 10; 201(2):265-83. PMID: 7287929.
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  133. Mesulam MM, Rosene DL. Journal of. Histochemistry and Cytochemistry. Sensitivity in horseradish peroxidase neurohistochemistry revisited (author's reply to Drs. Reiner and Gamlin). 1980; 28:189-191.
  134. Van Hoesen GW, Rosene DL, Mesulam MM. Subicular input from temporal cortex in the rhesus monkey. Science. 1979 Aug 10; 205(4406):608-10. PMID: 109926.
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  135. Vogt BA, Rosene DL, Pandya DN. Thalamic and cortical afferents differentiate anterior from posterior cingulate cortex in the monkey. Science. 1979 Apr 13; 204(4389):205-7. PMID: 107587.
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  136. Mesulam MM, Rosene DL. Sensitivity in horseradish peroxidase neurohistochemistry: a comparative and quantitative study of nine methods. J Histochem Cytochem. 1979 Mar; 27(3):763-73. PMID: 113450.
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  137. Swadlow HA, Rosene DL, Waxman SG. Characteristics of interhemispheric impulse conduction between prelunate gyri of the rhesus monkey. Exp Brain Res. 1978 Nov 15; 33(3-4):455-67. PMID: 103739.
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  138. Swadlow HA, Waxman SG, Rosene DL. Latency variability and the identification of antidromically activated neurons in mammalian brain. Exp Brain Res. 1978 Jul 14; 32(3):439-43. PMID: 98342.
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  139. Davis BJ, Macrides F, Youngs WM, Schneider SP, Rosene DL. Efferents and centrifugal afferents of the main and accessory olfactory bulbs in the hamster. Brain Res Bull. 1978 Jan-Feb; 3(1):59-72. PMID: 75756.
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  140. Rosene DL, Mesulam MM. Fixation variables in horseradish peroxidase neurohistochemistry. I. The effect of fixation time and perfusion procedures upon enzyme activity. J Histochem Cytochem. 1978 Jan; 26(1):28-39. PMID: 413864.
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  141. Lavyne MH, Koltun WA, Clement JA, Rosene DL, Pickren KS, Zervas NT, Wurtman RJ. Decrease in neostriatal blood flow after D-amphetamine administration or electrical stimulation of the substantia nigra. Brain Res. 1977 Oct 21; 135(1):77-86. PMID: 410481.
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  142. Rosene DL, Van Hoesen GW. Hippocampal efferents reach widespread areas of cerebral cortex and amygdala in the rhesus monkey. Science. 1977 Oct 21; 198(4314):315-7. PMID: 410102.
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  143. Mesulam MM, Rosene DL. Differential sensitivity between blue and brown reaction procedures for HRP neurohistochemistry. Neurosci Lett. 1977 Jun; 5(1-2):7-14. PMID: 19604963.
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  144. Heimer L, Van Hoesen GW, Rosene DL. The olfactory pathways and the anterior perforated substance in the primate brain. International Journal of Neurology. 1977; 12:42-52.
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