Keywords
Last Name

Camron D. Bryant, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-4489
ORCID ORCID Icon0000-0003-4505-5809
Other Positions
TitleDirector, Laboratory of Addiction Genetics
InstitutionBoston University School of Medicine

 Awards and Honors

Start-EndDescription
2016American College of Neuropsychopharmacology (ACNP): Elected Associate Member
2015Boston University: Jack Spivack Excellence in Neurosciences Research Award
2014International Behavioural and Neural Genetics Society (IBANGS): Young Scientist Award
2014Winter Conference on Brain Research (WCBR): Junior Investigator Travel Fellowship
2013World Congress of Psychiatric Genetics: Poster abstract selected for oral presentation
2013International Behavioural and Neural Genetics Society (IBANGS): Outstanding Young Investigator Award for Junior Faculty
2012International Behavioural and Neural Genetics Society (IBANGS): Travel Award
2011American College of Neuropsychopharmacology (ACNP): Early Career Travel Award - Abstract selected for Breakout Session oral presentation
2011International Narcotics Research Conference (INRC): Travel Award
2011NIDA: Travel Award for Miniconvention, “Frontiers in Addiction Research”
2011International Behavioural and Neural Genetics Society (IBANGS): Travel Award
2009International Behavioural and Neural Genetics Society (IBANGS): Travel Award
2008International Behavioural and Neural Genetics Society (IBANGS): Outstanding Young Investigator Award for Postdocs
2005INRC: Travel Award
2002INRC: Travel Award
2000UCLA: Hatos Center for Neuropharmacology Training Fellowship
1999UCLA: Achievement Rewards for College Scientists (ARCS) Scholarship
1998-1999UIUC: Honors Program and thesis in the Department of Psychology
 Research Expertise & Professional Interests
Dr. Bryant is the Director of the Laboratory of Addiction Genetics. Dr. Bryant’s research program is focused on determining the genetic basis of behavioral and molecular traits relevant to substance dependence in mice. The ultimate goal is to improve our understanding of the neurobiological mechanisms of addiction and to translate these findings toward treatment and prevention strategies in humans. A current focus is to determine the genetic basis of the rewarding properties of opioids in mice by combining quantitative trait locus (QTL) analysis of behavior and gene expression in genetic reference populations that yield high resolution QTLs. This multi-pronged approach to gene mapping will accelerate the nomination of candidate genes for validation via direct gene targeting. A separate focus with regard to functional characterization of candidate genes is the dissection of the hypothesized opposing roles of casein kinase-1 (CK-1) isoforms in regulating dopaminergic signaling and the motivational properties of drugs of abuse. Last, Dr. Bryant has a longstanding interest in deciphering the neurobiological basis of the “placebo effect”, a phenomenon that has been hypothesized to be mediated by the reward expectation. He plans to develop and apply a forward genetic analysis toward Pavlovian conditioning mouse models across a variety of conditions that are notoriously sensitive to the placebo effect, including pain, anxiety, depression, and Parkinson’s Disease.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kirkpatrick SL, Goldberg LR, Yazdani N, Babbs RK, Wu J, Reed ER, Jenkins DF, Bolgioni AF, Landaverde KI, Luttik KP, Mitchell KS, Kumar V, Johnson WE, Mulligan MK, Cottone P, Bryant CD. Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating. Biol Psychiatry. 2016 Oct 25. PMID: 27914629.
    View in: PubMed
  2. Young EE, Bryant CD, Lee SE, Peng X, Cook B, Nair HK, Dreher KJ, Zhang X, Palmer AA, Chung JM, Mogil JS, Chesler EJ, Lariviere WR. Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test. Genes Brain Behav. 2016 Jul; 15(6):604-15. PMID: 27231153.
    View in: PubMed
  3. Yazdani N, Shen Y, Johnson WE, Bryant CD. Striatal transcriptome analysis of a congenic mouse line (chromosome 11: 50-60Mb) exhibiting reduced methamphetamine sensitivity. Genom Data. 2016 Jun; 8:77-80. PMID: 27222804.
    View in: PubMed
  4. Bryant CD, Yazdani N. RNA-binding proteins, neural development and the addictions. Genes Brain Behav. 2016 Jan; 15(1):169-86. PMID: 26643147.
    View in: PubMed
  5. Yazdani N, Parker CC, Shen Y, Reed ER, Guido MA, Kole LA, Kirkpatrick SL, Lim JE, Sokoloff G, Cheng R, Johnson WE, Palmer AA, Bryant CD. Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity. PLoS Genet. 2015 Dec; 11(12):e1005713. PMID: 26658939.
    View in: PubMed
  6. Kirkpatrick SL, Bryant CD. Behavioral architecture of opioid reward and aversion in C57BL/6 substrains. Front Behav Neurosci. 2014; 8:450. PMID: 25628547.
    View in: PubMed
  7. Zhou L, Bryant CD, Loudon A, Palmer AA, Vitaterna MH, Turek FW. The circadian clock gene Csnk1e regulates rapid eye movement sleep amount, and nonrapid eye movement sleep architecture in mice. Sleep. 2014; 37(4):785-93, 793A-793C. PMID: 24744456.
    View in: PubMed
  8. Bryant CD, Guido MA, Kole LA, Cheng R. The heritability of oxycodone reward and concomitant phenotypes in a LG/J x SM/J F48 mouse advanced intercross line. Addiction Biology. 2014.
  9. Zhou L, Bryant CD, Loudon A, Palmer AA, Holz Vilaterna M, Turek FW. The circadian clock gene Csnk1e regulates rapid eye movement sleep amount, and nonrapid eye movement sleep architecture in mice. Sleep. 2014; 37(4):785-93. PMID: 25025121.
    View in: PubMed
  10. Bryant CD, Guido MA, Kole LA, Cheng R. The heritability of oxycodone reward and concomitant phenotypes in a LG/J?×?SM/J mouse advanced intercross line. Addict Biol. 2014 Jul; 19(4):552-61. PMID: 23231598.
    View in: PubMed
  11. Bryant CD, Kole LA, Guido MA, Cheng R, Palmer AA. Methamphetamine-induced conditioned place preference in LG/J and SM/J mouse strains and an F45/F46 advanced intercross line. Front Genet. 2012; 3:126. PMID: 22798962.
    View in: PubMed
  12. Bryant CD, Kole LA, Guido MA, Sokoloff G, Palmer AA. Congenic dissection of a major QTL for methamphetamine sensitivity implicates epistasis. Genes Brain Behav. 2012 Jul; 11(5):623-32. PMID: 22487465.
    View in: PubMed
  13. Bryant CD. The blessings and curses of C57BL/6 substrains in mouse genetic studies. Ann N Y Acad Sci. 2011 Dec; 1245:31-3. PMID: 22211972.
    View in: PubMed
  14. Bryant CD, Parker CC, Zhou L, Olker C, Chandrasekaran RY, Wager TT, Bolivar VJ, Loudon AS, Vitaterna MH, Turek FW, Palmer AA. Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids. Neuropsychopharmacology. 2012 Mar; 37(4):1026-35. PMID: 22089318.
    View in: PubMed
  15. Hofford RS, Hodgson SR, Roberts KW, Bryant CD, Evans CJ, Eitan S. Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal. Behav Pharmacol. 2009 Oct; 20(7):576-83. PMID: 19738463.
    View in: PubMed
  16. Bryant CD, Chang HP, Zhang J, Wiltshire T, Tarantino LM, Palmer AA. A major QTL on chromosome 11 influences psychostimulant and opioid sensitivity in mice. Genes Brain Behav. 2009 Nov; 8(8):795-805. PMID: 19694818.
    View in: PubMed
  17. Bryant CD, Roberts KW, Culbertson CS, Le A, Evans CJ, Fanselow MS. Pavlovian conditioning of multiple opioid-like responses in mice. Drug Alcohol Depend. 2009 Jul 1; 103(1-2):74-83. PMID: 19419821.
    View in: PubMed
  18. Bryant CD, Graham ME, Distler MG, Munoz MB, Li D, Vezina P, Sokoloff G, Palmer AA. A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine. Psychopharmacology (Berl). 2009 May; 203(4):703-11. PMID: 19050854.
    View in: PubMed
  19. Bryant CD, Zhang NN, Sokoloff G, Fanselow MS, Ennes HS, Palmer AA, McRoberts JA. Behavioral differences among C57BL/6 substrains: implications for transgenic and knockout studies. J Neurogenet. 2008; 22(4):315-31. PMID: 19085272.
    View in: PubMed
  20. Gioiosa L, Chen X, Watkins R, Klanfer N, Bryant CD, Evans CJ, Arnold AP. Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice. Horm Behav. 2008 Jan; 53(1):124-30. PMID: 17956759.
    View in: PubMed
  21. Bryant CD, Roberts KW, Byun JS, Fanselow MS, Evans CJ. Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice. Pharmacol Biochem Behav. 2006 Dec; 85(4):769-79. PMID: 17196637.
    View in: PubMed
  22. Bryant CD, Eitan S, Sinchak K, Fanselow MS, Evans CJ. NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 2006 Aug; 291(2):R315-26. PMID: 16601258.
    View in: PubMed
  23. Bryant CD, Zaki PA, Carroll FI, Evans CJ. Opioids and Addiction: Emerging pharmaceutical strategies for reducing reward and opponent processes. Clinical Neuroscience Research. 2005; (5):103-115.
  24. Lutfy K, Eitan S, Bryant CD, Yang YC, Saliminejad N, Walwyn W, Kieffer BL, Takeshima H, Carroll FI, Maidment NT, Evans CJ. Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. J Neurosci. 2003 Nov 12; 23(32):10331-7. PMID: 14614092.
    View in: PubMed
  25. Eitan S, Bryant CD, Saliminejad N, Yang YC, Vojdani E, Keith D, Polakiewicz R, Evans CJ. Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization. J Neurosci. 2003 Sep 10; 23(23):8360-9. PMID: 12967998.
    View in: PubMed
  26. Wilson SG, Bryant CD, Lariviere WR, Olsen MS, Giles BE, Chesler EJ, Mogil JS. The heritability of antinociception II: pharmacogenetic mediation of three over-the-counter analgesics in mice. J Pharmacol Exp Ther. 2003 May; 305(2):755-64. PMID: 12606637.
    View in: PubMed
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