Ci-Di Chen, PhD
Research Associate Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Illinois at Urbana–Champaign
MS, University of Illinois at Urbana–Champaign
MS, National Institute of Biological Sciences (NIBS)



I am interested in the research of normal brain aging and Alzheimer’s disease. My research interests are the mechanisms of the anti-aging protein, Klotho functions in the brain. My research is aimed to 1) Discovery of Klotho enhancing compounds. 2) Study the structure function of Klotho and identify the proteases responsible for Klotho shedding. 3) Decipher the role of Klotho in brain aging and identify the receptor for this anti-aging gene. 4) Study the mechanisms of Klotho effects on myelination. 5) Lowering Abeta production with a small molecular inhibitor of Alzheimer’s precursor protein dimerization.

2010 ELLISON FOUNDATION


The Significance of APP Dimerization in Alzheimer’s Disease
09/01/2006 - 08/31/2009 (Co-PI)
Alzheimer's Association




Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Abraham CR, Mullen PC, Tucker-Zhou T, Chen CD, Zeldich E. Klotho Is a Neuroprotective and Cognition-Enhancing Protein. Vitam Horm. 2016; 101:215-38.View Related Profiles. PMID: 27125744; DOI: 10.1016/bs.vh.2016.02.004;.
  2. Zeldich E, Chen CD, Avila R, Medicetty S, Abraham CR. The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination. J Mol Neurosci. 2015 Oct; 57(2):185-96.View Related Profiles. PMID: 26067431; DOI: 10.1007/s12031-015-0598-2;.
  3. Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR. Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry. 2014 Sep 2; 53(34):5579-87.View Related Profiles. PMID: 25110992; PMCID: PMC4151695; DOI: 10.1021/bi500409n;.
  4. Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol. 2014 Sep; 76(3):379-92.View Related Profiles. PMID: 25043464; DOI: 10.1002/ana.24219;.
  5. Zeldich E, Chen CD, Colvin TA, Bove-Fenderson EA, Liang J, Tucker Zhou TB, Harris DA, Abraham CR. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014 Aug 29; 289(35):24700-15.View Related Profiles. PMID: 25037225; PMCID: PMC4148892; DOI: 10.1074/jbc.M114.567321;.
  6. Chen CD, Li H, Liang J, Hixson K, Zeldich E, Abraham CR. The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line. J Mol Neurosci. 2015 Jan; 55(1):76-90.View Related Profiles. PMID: 24907942; DOI: 10.1007/s12031-014-0336-1;.
  7. So PP, Khodr CE, Chen CD, Abraham CR. Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants. Am J Neurodegener Dis. 2013; 2(1):15-28.View Related Profiles. PMID: 23515184; PMCID: PMC3601467.
  8. Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013 Jan 30; 33(5):1927-39.View Related Profiles. PMID: 23365232; PMCID: PMC3711388; DOI: 10.1523/JNEUROSCI.2080-12.2013;.
  9. So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-ß precursor protein dimerization. Am J Neurodegener Dis. 2012; 1(1):75-87.View Related Profiles. PMID: 22822474; PMCID: PMC3560454.
  10. So PP, Chen CD, Abraham CR. Detection of amyloid-ß protein precursor homo-interactions using beta-galactosidase enzyme fragment complementation. J Alzheimers Dis. 2011; 26(4):647-55.View Related Profiles. PMID: 21694460; DOI: 10.3233/JAD-2011-110323;.
Showing 10 of 16 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 16 publications over 11 distinct years, with a maximum of 4 publications in 2014

YearPublications
20051
20061
20071
20082
20101
20111
20121
20132
20144
20151
20161
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

anti-aging; Alzheimer’s disease research; Klotho
Contact for Mentoring:


72 E. Concord St Silvio Conte (K)
Boston MA 02118
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