Keywords
Last Name

Ci-Di Chen, PhD

TitleResearch Assistant Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-4315
ORCID ORCID Icon0000-0001-7112-2230
 Awards and Honors

Start-EndDescription
2010ELLISON FOUNDATION
 Research Expertise & Professional Interests
I am interested in the research of normal brain aging and Alzheimer’s disease. My research interests are the mechanisms of the anti-aging protein, Klotho functions in the brain. My research is aimed to 1) Discovery of Klotho enhancing compounds. 2) Study the structure function of Klotho and identify the proteases responsible for Klotho shedding. 3) Decipher the role of Klotho in brain aging and identify the receptor for this anti-aging gene. 4) Study the mechanisms of Klotho effects on myelination. 5) Lowering Abeta production with a small molecular inhibitor of Alzheimer’s precursor protein dimerization.

 Self-Described Keywords
  • anti-aging; Alzheimer’s disease research; Klotho
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Abraham CR, Mullen PC, Tucker-Zhou T, Chen CD, Zeldich E. Klotho Is a Neuroprotective and Cognition-Enhancing Protein. Vitam Horm. 2016; 101:215-38. PMID: 27125744.
    View in: PubMed
  2. Zeldich E, Chen CD, Avila R, Medicetty S, Abraham CR. The Anti-Aging Protein Klotho Enhances Remyelination Following Cuprizone-Induced Demyelination. J Mol Neurosci. 2015 Oct; 57(2):185-96. PMID: 26067431.
    View in: PubMed
  3. Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR. Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry. 2014 Sep 2; 53(34):5579-87. PMID: 25110992.
    View in: PubMed
  4. Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol. 2014 Sep; 76(3):379-92. PMID: 25043464.
    View in: PubMed
  5. Zeldich E, Chen CD, Colvin TA, Bove-Fenderson EA, Liang J, Tucker Zhou TB, Harris DA, Abraham CR. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 2014 Aug 29; 289(35):24700-15. PMID: 25037225.
    View in: PubMed
  6. Chen CD, Li H, Liang J, Hixson K, Zeldich E, Abraham CR. The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line. J Mol Neurosci. 2015 Jan; 55(1):76-90. PMID: 24907942.
    View in: PubMed
  7. So PP, Khodr CE, Chen CD, Abraham CR. Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants. Am J Neurodegener Dis. 2013; 2(1):15-28. PMID: 23515184.
    View in: PubMed
  8. Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke JI, Kuro-o M, Abraham CR. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci. 2013 Jan 30; 33(5):1927-39. PMID: 23365232.
    View in: PubMed
  9. So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-ß precursor protein dimerization. Am J Neurodegener Dis. 2012; 1(1):75-87. PMID: 22822474.
    View in: PubMed
  10. So PP, Chen CD, Abraham CR. Detection of amyloid-ß protein precursor homo-interactions using beta-galactosidase enzyme fragment complementation. J Alzheimers Dis. 2011; 26(4):647-55. PMID: 21694460.
    View in: PubMed
  11. Oh SY, Chen CD, Abraham CR. Cell-type dependent modulation of Notch signaling by the amyloid precursor protein. J Neurochem. 2010 Apr; 113(1):262-74. PMID: 20089128.
    View in: PubMed
  12. Zerbinatti CV, Cordy JM, Chen CD, Guillily M, Suon S, Ray WJ, Seabrook GR, Abraham CR, Wolozin B. Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein. Mol Neurodegener. 2008; 3:5. PMID: 18348724.
    View in: PubMed
  13. Hinman JD, Chen CD, Oh SY, Hollander W, Abraham CR. Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts. Glia. 2008 Jan 1; 56(1):118-33. PMID: 17963267.
    View in: PubMed
  14. Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19796-801. PMID: 18056631.
    View in: PubMed
  15. Chen CD, Oh SY, Hinman JD, Abraham CR. Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation. J Neurochem. 2006 Apr; 97(1):30-43. PMID: 16515557.
    View in: PubMed
  16. Oh SY, Ellenstein A, Chen CD, Hinman JD, Berg EA, Costello CE, Yamin R, Neve RL, Abraham CR. Amyloid precursor protein interacts with notch receptors. J Neurosci Res. 2005 Oct 1; 82(1):32-42. PMID: 16118793.
    View in: PubMed
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