Keywords
Last Name

John A. Porco, PhD

TitleProfessor
InstitutionBoston University College of Arts and Sciences
DepartmentChemistry
Address590 Commonwealth Ave
Boston MA 02215
Phone(617) 353-2493
Fax(617) 353-6466
Other Positions
TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics

 Research Expertise & Professional Interests
John Porco investigates chemical syntheses of complex molecules and synthesis of complex chemical libraries of novel structural types. John joined the Department of Chemistry at Boston University in 1999 after a successful career in industry and was rapidly promoted to Professor of Chemistry in September 2004.

Research in the Porco Group is focused in two major areas: the development of new synthetic methodologies for efficient chemical synthesis of complex molecules and synthesis of complex chemical libraries, the latter conducted at the Boston University Center for Molecular Discovery. Synthetic methodologies developed in the Porco Laboratory include copper (I)-mediated formation of enamides, oxa-electrocyclization/dimerization of dienals enroute to complex epoxyquinoids; enantioselective oxidative dearomatization using chiral copper complexes and molecular oxygen; photocycloaddition using oxidopyryliums enroute to the rocaglamides and related natural products, and catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes.

-Dearomatization Strategies in Complex Synthesis aim to utilize aromatic scaffolds as starting materials as precursors to complex natural products.

-Faculty Profile Scientific Image Porco 1Biomimetic Synthesis Approaches involve development of methodologies to test plausible biosyntheses of complex natural products and derivatives.

-New Reaction Discovery is done in conjunction with the BU-CMD and aims to discover transformations leading to novel chemotypes.

Techniques & Resources:

-Organic Synthesis techniques are used and include modern methods for synthesis, purification, and analysis of organic molecules
.
-Boston University Center for Molecular Discovery (BU-CMD) is an NIH-funded Center at Boston University which focuses on development of new methodologies for the synthesis of complex chemical libraries.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Boyce JH, Eschenbrenner-Lux V, Porco JA. Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations. J Am Chem Soc. 2016 Nov 09; 138(44):14789-14797. PMID: 27744695.
    View in: PubMed
  2. Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes. European J Org Chem. 2016 Oct; 2016(28):4800-4804. PMID: 28082832.
    View in: PubMed
  3. Ingham OJ, Paranal RM, Smith WB, Escobar RA, Yueh H, Snyder T, Porco JA, Bradner JE, Beeler AB. Development of a Potent and Selective HDAC8 Inhibitor. ACS Med Chem Lett. 2016 Oct 13; 7(10):929-932. PMID: 27774131.
    View in: PubMed
  4. Wang W, Cencic R, Whitesell L, Pelletier J, Porco JA. Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition. Chemistry. 2016 Aug 16; 22(34):12006-10. PMID: 27338157.
    View in: PubMed
  5. Chu J, Galicia-Vázquez G, Cencic R, Mills JR, Katigbak A, Porco JA, Pelletier J. CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A. Cell Rep. 2016 Jun 14; 15(11):2340-7. PMID: 27239032.
    View in: PubMed
  6. Kärkäs MD, Porco JA, Stephenson CR. Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. Chem Rev. 2016 Sep 14; 116(17):9683-747. PMID: 27120289.
    View in: PubMed
  7. Bhattacharya B, Chatterjee S, Devine WG, Kobzik L, Beeler AB, Porco JA, Kramnik I. Fine-tuning of macrophage activation using synthetic rocaglate derivatives. Sci Rep. 2016 Apr 18; 6:24409. PMID: 27086720.
    View in: PubMed
  8. Gandin V, Masvidal L, Hulea L, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA, St-Pierre J, Pelletier J, Larsson O, Topisirovic I. nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs. Genome Res. 2016 May; 26(5):636-48. PMID: 26984228.
    View in: PubMed
  9. Qi C, Xiong Y, Eschenbrenner-Lux V, Cong H, Porco JA. Asymmetric Syntheses of the Flavonoid Diels-Alder Natural Products Sanggenons C and O. J Am Chem Soc. 2016 Jan 27; 138(3):798-801. PMID: 26735066.
    View in: PubMed
  10. Qin T, Iwata T, Ransom TT, Beutler JA, Porco JA. Syntheses of Dimeric Tetrahydroxanthones with Varied Linkages: Investigation of "Shapeshifting" Properties. J Am Chem Soc. 2015 Dec 9; 137(48):15225-33. PMID: 26544765.
    View in: PubMed
  11. Chu J, Cencic R, Wang W, Porco JA, Pelletier J. Translation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status. Mol Cancer Ther. 2016 Jan; 15(1):136-41. PMID: 26586722.
    View in: PubMed
  12. Gervais A, Lazarski KE, Porco JA. Divergent Total Syntheses of Rhodomyrtosones A and B. J Org Chem. 2015 Oct 2; 80(19):9584-91. PMID: 26351970.
    View in: PubMed
  13. Liu S, Wang W, Brown LE, Qiu C, Lajkiewicz N, Zhao T, Zhou J, Porco JA, Wang TT. A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway. EBioMedicine. 2015 Nov; 2(11):1600-6. PMID: 26870784.
    View in: PubMed
  14. Yeo AT, Chennamadhavuni S, Whitty A, Porco JA, Gilmore TD. Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines. Molecules. 2015; 20(5):7474-94. PMID: 25915462.
    View in: PubMed
  15. Qin T, Skraba-Joiner SL, Khalil ZG, Johnson RP, Capon RJ, Porco JA. Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer. Nat Chem. 2015 Mar; 7(3):234-40. PMID: 25698333.
    View in: PubMed
  16. Stone SD, Lajkiewicz NJ, Whitesell L, Hilmy A, Porco JA. Biomimetic kinetic resolution: highly enantio- and diastereoselective transfer hydrogenation of aglain ketones to access flavagline natural products. J Am Chem Soc. 2015 Jan 14; 137(1):525-30. PMID: 25514979.
    View in: PubMed
  17. Yeung CS, Ziegler RE, Porco JA, Jacobsen EN. Thiourea-catalyzed enantioselective addition of indoles to pyrones: alkaloid cores with quaternary carbons. J Am Chem Soc. 2014 Oct 1; 136(39):13614-7. PMID: 25213353.
    View in: PubMed
  18. Zhu L, Qi J, Chiao CY, Zhang Q, Porco JA, Faller DV, Dai Y. Identification of a novel polyprenylated acylphloroglucinol-derived SIRT1 inhibitor with cancer-specific anti-proliferative and invasion-suppressing activities. Int J Oncol. 2014 Nov; 45(5):2128-36. PMID: 25189993.
    View in: PubMed
  19. Robert F, Roman W, Bramoullé A, Fellmann C, Roulston A, Shustik C, Porco JA, Shore GC, Sebag M, Pelletier J. Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13421-6. PMID: 25197055.
    View in: PubMed
  20. Grenning AJ, Boyce JH, Porco JA. Rapid synthesis of polyprenylated acylphloroglucinol analogs via dearomative conjunctive allylic annulation. J Am Chem Soc. 2014 Aug 20; 136(33):11799-804. PMID: 25061804.
    View in: PubMed
  21. Wolfe AL, Singh K, Zhong Y, Drewe P, Rajasekhar VK, Sanghvi VR, Mavrakis KJ, Jiang M, Roderick JE, Van der Meulen J, Schatz JH, Rodrigo CM, Zhao C, Rondou P, de Stanchina E, Teruya-Feldstein J, Kelliher MA, Speleman F, Porco JA, Pelletier J, Rätsch G, Wendel HG. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature. 2014 Sep 4; 513(7516):65-70. PMID: 25079319.
    View in: PubMed
  22. Villar EA, Beglov D, Chennamadhavuni S, Porco JA, Kozakov D, Vajda S, Whitty A. How proteins bind macrocycles. Nat Chem Biol. 2014 Sep; 10(9):723-31. PMID: 25038790.
    View in: PubMed
  23. Boyce JH, Porco JA. Asymmetric, stereodivergent synthesis of (-)-clusianone utilizing a biomimetic cationic cyclization. Angew Chem Int Ed Engl. 2014 Jul 21; 53(30):7832-7. PMID: 24916169.
    View in: PubMed
  24. Martin VI, Goodell JR, Ingham OJ, Porco JA, Beeler AB. Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes. J Org Chem. 2014 May 2; 79(9):3838-46. PMID: 24697145.
    View in: PubMed
  25. Qi C, Qin T, Suzuki D, Porco JA. Total synthesis and stereochemical assignment of (±)-sorbiterrin A. J Am Chem Soc. 2014 Mar 5; 136(9):3374-7. PMID: 24547688.
    View in: PubMed
  26. Qin T, Porco JA. Total syntheses of secalonic acids A and D. Angew Chem Int Ed Engl. 2014 Mar 17; 53(12):3107-10. PMID: 24519991.
    View in: PubMed
  27. Lajkiewicz NJ, Cognetta AB, Niphakis MJ, Cravatt BF, Porco JA. Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived ß-lactone. J Am Chem Soc. 2014 Feb 12; 136(6):2659-64. PMID: 24447064.
    View in: PubMed
  28. Grenning AJ, Snyder JK, Porco JA. Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction. Org Lett. 2014 Feb 7; 16(3):792-5. PMID: 24410175.
    View in: PubMed
  29. Bos PH, Antalek MT, Porco JA, Stephenson CR. Tandem dienone photorearrangement-cycloaddition for the rapid generation of molecular complexity. J Am Chem Soc. 2013 Nov 27; 135(47):17978-82. PMID: 24161069.
    View in: PubMed
  30. Nasr Z, Dow LE, Paquet M, Chu J, Ravindar K, Somaiah R, Deslongchamps P, Porco JA, Lowe SW, Pelletier J. Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia. BMC Pharmacol Toxicol. 2013; 14:58. PMID: 24219888.
    View in: PubMed
  31. Winter DK, Endoma-Arias MA, Hudlicky T, Beutler JA, Porco JA. Enantioselective total synthesis and biological evaluation of (+)-kibdelone A and a tetrahydroxanthone analogue. J Org Chem. 2013 Aug 2; 78(15):7617-26. PMID: 23834060.
    View in: PubMed
  32. Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA, Whitesell L, Lindquist S. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science. 2013 Jul 19; 341(6143):1238303. PMID: 23869022.
    View in: PubMed
  33. Qi C, Cong H, Cahill KJ, Müller P, Johnson RP, Porco JA. Biomimetic dehydrogenative Diels-Alder cycloadditions: total syntheses of brosimones A and B. Angew Chem Int Ed Engl. 2013 Aug 5; 52(32):8345-8. PMID: 23818217.
    View in: PubMed
  34. Sadlish H, Galicia-Vazquez G, Paris CG, Aust T, Bhullar B, Chang L, Helliwell SB, Hoepfner D, Knapp B, Riedl R, Roggo S, Schuierer S, Studer C, Porco JA, Pelletier J, Movva NR. Evidence for a functionally relevant rocaglamide binding site on the eIF4A-RNA complex. ACS Chem Biol. 2013 Jul 19; 8(7):1519-27. PMID: 23614532.
    View in: PubMed
  35. Xiong Y, Schaus SE, Porco JA. Metal-catalyzed cascade rearrangements of 3-alkynyl flavone ethers. Org Lett. 2013 Apr 19; 15(8):1962-5. PMID: 23574045.
    View in: PubMed
  36. Winter DK, Sloman DL, Porco JA. Polycyclic xanthone natural products: structure, biological activity and chemical synthesis. Nat Prod Rep. 2013 Mar; 30(3):382-91. PMID: 23334431.
    View in: PubMed
  37. Dong S, Qin T, Hamel E, Beutler JA, Porco JA. Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation. J Am Chem Soc. 2012 Dec 5; 134(48):19782-7. PMID: 23110297.
    View in: PubMed
  38. Leng B, Chichetti S, Su S, Beeler AB, Porco JA. Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations. Beilstein J Org Chem. 2012; 8:1338-43. PMID: 23019468.
    View in: PubMed
  39. Ziegler RE, Tan SJ, Kam TS, Porco JA. Development of an alkaloid-pyrone annulation: synthesis of pleiomaltinine. Angew Chem Int Ed Engl. 2012 Sep 10; 51(37):9348-51. PMID: 22893619.
    View in: PubMed
  40. Lajkiewicz NJ, Roche SP, Gerard B, Porco JA. Enantioselective photocycloaddition of 3-hydroxyflavones: total syntheses and absolute configuration assignments of (+)-ponapensin and (+)-elliptifoline. J Am Chem Soc. 2012 Aug 8; 134(31):13108-13. PMID: 22804454.
    View in: PubMed
  41. Jin C, Rajabi H, Rodrigo CM, Porco JA, Kufe D. Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 2013 Apr 25; 32(17):2179-88. PMID: 22689062.
    View in: PubMed
  42. Porco JA. Recent developments in chemical diversity. Beilstein J Org Chem. 2012; 8:827-8. PMID: 23015830.
    View in: PubMed
  43. Little A, Porco JA. Total syntheses of graphisin A and sydowinin B. Org Lett. 2012 Jun 1; 14(11):2862-5. PMID: 22621405.
    View in: PubMed
  44. Scully SS, Porco JA. Studies toward the synthesis of the epoxykinamycin FL-120B': discovery of a decarbonylative photocyclization. Org Lett. 2012 May 18; 14(10):2646-9. PMID: 22571279.
    View in: PubMed
  45. Cong H, Porco JA. Total synthesis of (±)-sorocenol B employing nanoparticle catalysis. Org Lett. 2012 May 18; 14(10):2516-9. PMID: 22553903.
    View in: PubMed
  46. Lin CJ, Nasr Z, Premsrirut PK, Porco JA, Hippo Y, Lowe SW, Pelletier J. Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. Cell Rep. 2012 Apr 19; 1(4):325-33. PMID: 22573234.
    View in: PubMed
  47. Nasr Z, Robert F, Porco JA, Muller WJ, Pelletier J. eIF4F suppression in breast cancer affects maintenance and progression. Oncogene. 2013 Feb 14; 32(7):861-71. PMID: 22484424.
    View in: PubMed
  48. Zhang Q, Porco JA. Total synthesis of (±)-7-epi-nemorosone. Org Lett. 2012 Apr 6; 14(7):1796-9. PMID: 22449198.
    View in: PubMed
  49. Achard M, Beeler AB, Porco JA. Synthesis of azaphilone-based chemical libraries. ACS Comb Sci. 2012 Mar 12; 14(3):236-44. PMID: 22330196.
    View in: PubMed
  50. Cong H, Porco JA. Chemical Synthesis of Complex Molecules Using Nanoparticle Catalysis. ACS Catal. 2012 Jan 1; 2(1):65-70. PMID: 22347681.
    View in: PubMed
  51. Rodrigo CM, Cencic R, Roche SP, Pelletier J, Porco JA. Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies. J Med Chem. 2012 Jan 12; 55(1):558-62. PMID: 22128783.
    View in: PubMed
  52. Yeo AT, Porco JA, Gilmore TD. Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis. Cancer Lett. 2012 May 1; 318(1):53-60. PMID: 22155272.
    View in: PubMed
  53. Balthaser BR, Maloney MC, Beeler AB, Porco JA, Snyder JK. Remodelling of the natural product fumagillol employing a reaction discovery approach. Nat Chem. 2011 Dec; 3(12):969-73. PMID: 22213919.
    View in: PubMed
  54. Deb Majumdar I, Devanabanda A, Fox B, Schwartzman J, Cong H, Porco JA, Weber HC. Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro. Biochem Biophys Res Commun. 2011 Dec 16; 416(3-4):397-402. PMID: 22120630.
    View in: PubMed
  55. Goodell JR, Poole JL, Beeler AB, Aubé J, Porco JA. Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes. J Org Chem. 2011 Dec 2; 76(23):9792-800. PMID: 22007996.
    View in: PubMed
  56. Dong S, Cahill KJ, Kang MI, Colburn NH, Henrich CJ, Wilson JA, Beutler JA, Johnson RP, Porco JA. Microwave-based reaction screening: tandem retro-Diels-Alder/Diels-Alder cycloadditions of o-quinol dimers. J Org Chem. 2011 Nov 4; 76(21):8944-54. PMID: 21942286.
    View in: PubMed
  57. Scully SS, Porco JA. Asymmetric total synthesis of the epoxykinamycin FL-120?B'. Angew Chem Int Ed Engl. 2011 Oct 4; 50(41):9722-6. PMID: 21953671.
    View in: PubMed
  58. Schatz JH, Oricchio E, Wolfe AL, Jiang M, Linkov I, Maragulia J, Shi W, Zhang Z, Rajasekhar VK, Pagano NC, Porco JA, Teruya-Feldstein J, Rosen N, Zelenetz AD, Pelletier J, Wendel HG. Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. J Exp Med. 2011 Aug 29; 208(9):1799-807. PMID: 21859846.
    View in: PubMed
  59. Brown LE, Dai P, Porco JA, Schaus SE. Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones. Org Lett. 2011 Aug 19; 13(16):4228-31. PMID: 21749159.
    View in: PubMed
  60. Medeiros MR, Schaus SE, Porco JA. A cycloisomerization/Friedel-Crafts alkylation strategy for the synthesis of pyrano[3,4-b]indoles. Org Lett. 2011 Aug 5; 13(15):4012-5. PMID: 21740020.
    View in: PubMed
  61. Sloman DL, Bacon JW, Porco JA. Total synthesis and absolute stereochemical assignment of kibdelone C. J Am Chem Soc. 2011 Jul 6; 133(26):9952-5. PMID: 21648477.
    View in: PubMed
  62. Wu J, Becerril J, Lian Y, Davies HM, Porco JA, Panek JS. Sequential transformations to access polycyclic chemotypes: asymmetric crotylation and metal carbenoid reactions. Angew Chem Int Ed Engl. 2011 Jun 20; 50(26):5938-42. PMID: 21560214.
    View in: PubMed
  63. Roche SP, Porco JA. Dearomatization strategies in the synthesis of complex natural products. Angew Chem Int Ed Engl. 2011 Apr 26; 50(18):4068-93. PMID: 21506209.
    View in: PubMed
  64. Brown LE, Chih-Chien Cheng K, Wei WG, Yuan P, Dai P, Trilles R, Ni F, Yuan J, MacArthur R, Guha R, Johnson RL, Su XZ, Dominguez MM, Snyder JK, Beeler AB, Schaus SE, Inglese J, Porco JA. Discovery of new antimalarial chemotypes through chemical methodology and library development. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6775-80. PMID: 21498685.
    View in: PubMed
  65. Germain AR, Bruggemeyer DM, Zhu J, Genet C, O'Brien P, Porco JA. Synthesis of the azaphilones (+)-sclerotiorin and (+)-8-O-methylsclerotiorinamine utilizing (+)-sparteine surrogates in copper-mediated oxidative dearomatization. J Org Chem. 2011 Apr 15; 76(8):2577-84. PMID: 21401026.
    View in: PubMed
  66. Xia B, Gerard B, Solano DM, Wan J, Jones G, Porco JA. ESIPT-mediated photocycloadditions of 3-hydroxyquinolinones: development of a fluorescence quenching assay for reaction screening. Org Lett. 2011 Mar 18; 13(6):1346-9. PMID: 21338078.
    View in: PubMed
  67. Sloman DL, Mitasev B, Scully SS, Beutler JA, Porco JA. Synthesis and biological evaluation of ABCD ring fragments of the kibdelones. Angew Chem Int Ed Engl. 2011 Mar 7; 50(11):2511-5. PMID: 21370327.
    View in: PubMed
  68. Qin T, Johnson RP, Porco JA. Vinylogous addition of siloxyfurans to benzopyryliums: a concise approach to the tetrahydroxanthone natural products. J Am Chem Soc. 2011 Feb 16; 133(6):1714-7. PMID: 21265529.
    View in: PubMed
  69. Ebada SS, Lajkiewicz N, Porco JA, Li-Weber M, Proksch P. Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae). Prog Chem Org Nat Prod. 2011; 94:1-58. PMID: 21833837.
    View in: PubMed
  70. Zhang Q, Mitasev B, Qi J, Porco JA. Total synthesis of plukenetione A. J Am Chem Soc. 2010 Oct 13; 132(40):14212-5. PMID: 20843036.
    View in: PubMed
  71. Qi J, Beeler AB, Zhang Q, Porco JA. Catalytic enantioselective alkylative dearomatization-annulation: total synthesis and absolute configuration assignment of hyperibone K. J Am Chem Soc. 2010 Oct 6; 132(39):13642-4. PMID: 20831187.
    View in: PubMed
  72. Roche SP, Cencic R, Pelletier J, Porco JA. Biomimetic photocycloaddition of 3-hydroxyflavones: synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation. Angew Chem Int Ed Engl. 2010 Sep 3; 49(37):6533-8. PMID: 20687060.
    View in: PubMed
  73. Medeiros MR, Narayan RS, McDougal NT, Schaus SE, Porco JA. Skeletal diversity via cationic rearrangements of substituted dihydropyrans. Org Lett. 2010 Jul 16; 12(14):3222-5. PMID: 20550144.
    View in: PubMed
  74. Marié JC, Xiong Y, Min GK, Yeager AR, Taniguchi T, Berova N, Schaus SE, Porco JA. Enantioselective synthesis of 3,4-chromanediones via asymmetric rearrangement of 3-allyloxyflavones. J Org Chem. 2010 Jul 2; 75(13):4584-90. PMID: 20527786.
    View in: PubMed
  75. Goodell JR, Leng B, Snyder TK, Beeler AB, Porco JA. Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones. Synthesis (Stuttg). 2010 Jul 1; 2010(13):2254-2270. PMID: 25132691.
    View in: PubMed
  76. Cong H, Becker CF, Elliott SJ, Grinstaff MW, Porco JA. Silver nanoparticle-catalyzed Diels-Alder cycloadditions of 2'-hydroxychalcones. J Am Chem Soc. 2010 Jun 2; 132(21):7514-8. PMID: 20443601.
    View in: PubMed
  77. Kinoshita H, Ingham OJ, Ong WW, Beeler AB, Porco JA. Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation. J Am Chem Soc. 2010 May 12; 132(18):6412-8. PMID: 20394364.
    View in: PubMed
  78. Treece JL, Goodell JR, Vander Velde D, Porco JA, Aubé J. Reaction discovery using microfluidic-based multidimensional screening of polycyclic iminium ethers. J Org Chem. 2010 Mar 19; 75(6):2028-38. PMID: 20163127.
    View in: PubMed
  79. Liang B, Kalidindi S, Porco JA, Stephenson CR. Multicomponent reaction discovery: three-component synthesis of spirooxindoles. Org Lett. 2010 Feb 5; 12(3):572-5. PMID: 20050598.
    View in: PubMed
  80. Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD. A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization. Assay Drug Dev Technol. 2010 Feb; 8(1):96-105. PMID: 20035614.
    View in: PubMed
  81. Cencic R, Carrier M, Trnkus A, Porco JA, Minden M, Pelletier J. Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells. Leuk Res. 2010 Apr; 34(4):535-41. PMID: 19726085.
    View in: PubMed
  82. Goodell JR, McMullen JP, Zaborenko N, Maloney JR, Ho CX, Jensen KF, Porco JA, Beeler AB. Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds. J Org Chem. 2009 Aug 21; 74(16):6169-80. PMID: 20560568.
    View in: PubMed
  83. Castaldi MP, Troast DM, Porco JA. Stereoselective synthesis of spirocyclic oxindoles via Prins cyclizations. Org Lett. 2009 Aug 6; 11(15):3362-5. PMID: 19719184.
    View in: PubMed
  84. Mitasev B, Porco JA. Manganese(III)-mediated transformations of phloroglucinols: a formal oxidative [4 + 2] cycloaddition leading to bicyclo[2.2.2]octadiones. Org Lett. 2009 Jun 4; 11(11):2285-8. PMID: 19415907.
    View in: PubMed
  85. Cencic R, Carrier M, Galicia-Vázquez G, Bordeleau ME, Sukarieh R, Bourdeau A, Brem B, Teodoro JG, Greger H, Tremblay ML, Porco JA, Pelletier J. Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol. PLoS One. 2009; 4(4):e5223. PMID: 19401772.
    View in: PubMed
  86. Han C, Rangarajan S, Voukides AC, Beeler AB, Johnson R, Porco JA. Reaction discovery employing macrocycles: transannular cyclizations of macrocyclic bis-lactams. Org Lett. 2009 Jan 15; 11(2):413-6. PMID: 19102683.
    View in: PubMed
  87. Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA. Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor. Angew Chem Int Ed Engl. 2009; 48(8):1494-7. PMID: 19140149.
    View in: PubMed
  88. Troast DM, Yuan J, Porco JA. Studies Toward the Synthesis of (-)-Zampanolide: Preparation of the Macrocyclic Core. Adv Synth Catal. 2008 Aug 4; 350(11-12):1701-1711. PMID: 23543877.
    View in: PubMed
  89. Bordeleau ME, Robert F, Gerard B, Lindqvist L, Chen SM, Wendel HG, Brem B, Greger H, Lowe SW, Porco JA, Pelletier J. Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J Clin Invest. 2008 Jul; 118(7):2651-60. PMID: 18551192.
    View in: PubMed
  90. Cong H, Ledbetter D, Rowe GT, Caradonna JP, Porco JA. Electron transfer-initiated Diels-Alder cycloadditions of 2'-hydroxychalcones. J Am Chem Soc. 2008 Jul 23; 130(29):9214-5. PMID: 18576647.
    View in: PubMed
  91. Dong S, Zhu J, Porco JA. Enantioselective synthesis of bicyclo[2.2.2]octenones using a copper-mediated oxidative dearomatization/[4 + 2] dimerization cascade. J Am Chem Soc. 2008 Mar 5; 130(9):2738-9. PMID: 18266375.
    View in: PubMed
  92. Williams AJ, Elyashberg ME, Blinov KA, Lankin DC, Martin GE, Reynolds WF, Porco JA, Singleton CA, Su S. Applying computer-assisted structure elucidation algorithms for the purpose of structure validation: revisiting the NMR assignments of hexacyclinol. J Nat Prod. 2008 Apr; 71(4):581-8. PMID: 18257535.
    View in: PubMed
  93. Kesavan S, Panek JS, Porco JA. Preparation of alkylidene indane and related scaffolds and their further elaboration to novel chemotypes. Org Lett. 2007 Dec 6; 9(25):5203-6. PMID: 17997565.
    View in: PubMed
  94. Su S, Porco JA. 1,2-dihydroisoquinolines as templates for cascade reactions to access isoquinoline alkaloid frameworks. Org Lett. 2007 Nov 22; 9(24):4983-6. PMID: 17958365.
    View in: PubMed
  95. Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6836-40. PMID: 17964153.
    View in: PubMed
  96. Qi J, Porco JA. Rapid access to polyprenylated phloroglucinols via alkylative dearomatization-annulation: total synthesis of (+/-)-clusianone(1). J Am Chem Soc. 2007 Oct 24; 129(42):12682-3. PMID: 17902679.
    View in: PubMed
  97. Dandapani S, Duduta M, Panek JS, Porco JA. Skeletal diversity through radical cyclization of tetrahydropyridine scaffolds. Org Lett. 2007 Sep 13; 9(19):3849-52. PMID: 17713919.
    View in: PubMed
  98. Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA, Schreiber SL, Chung RT. Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrob Agents Chemother. 2007 Oct; 51(10):3756-9. PMID: 17682098.
    View in: PubMed
  99. Su S, Porco JA. Synthesis of pyrrolo-isoquinolines related to the lamellarins using silver-catalyzed cycloisomerization/dipolar cycloaddition. J Am Chem Soc. 2007 Jun 27; 129(25):7744-5. PMID: 17539647.
    View in: PubMed
  100. Comer E, Rohan E, Deng L, Porco JA. An approach to skeletal diversity using functional group pairing of multifunctional scaffolds. Org Lett. 2007 May 24; 9(11):2123-6. PMID: 17472394.
    View in: PubMed
  101. Porco JA. Organic chemistry: synthesis undressed. Nature. 2007 Mar 22; 446(7134):383-5. PMID: 17377569.
    View in: PubMed
  102. Chen Y, Porco JA, Panek JS. Stereochemical and skeletal diversity employing pipecolate ester scaffolds. Org Lett. 2007 Apr 12; 9(8):1529-32. PMID: 17367153.
    View in: PubMed
  103. Han C, Porco JA. Synthesis of carbamates and ureas using Zr(IV)-catalyzed exchange processes. Org Lett. 2007 Apr 12; 9(8):1517-20. PMID: 17358074.
    View in: PubMed
  104. Beeler AB, Su S, Singleton CA, Porco JA. Discovery of chemical reactions through multidimensional screening. J Am Chem Soc. 2007 Feb 7; 129(5):1413-9. PMID: 17263426.
    View in: PubMed
  105. Zhou Y, Porco JA, Snyder JK. Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations. Org Lett. 2007 Feb 1; 9(3):393-6. PMID: 17249770.
    View in: PubMed
  106. Ong WW, Beeler AB, Kesavan S, Panek JS, Porco JA. Nucleophilic addition to N-phosphinylimines by rare-earth-metal triflate/trifluoroacetic anhydride activation. Angew Chem Int Ed Engl. 2007; 46(39):7470-2. PMID: 17722135.
    View in: PubMed
  107. Gerard B, Cencic R, Pelletier J, Porco JA. Enantioselective synthesis of the complex rocaglate (-)-silvestrol. Angew Chem Int Ed Engl. 2007; 46(41):7831-4. PMID: 17806093.
    View in: PubMed
  108. Lei X, Porco JA. Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1. J Am Chem Soc. 2006 Nov 22; 128(46):14790-1. PMID: 17105273.
    View in: PubMed
  109. Dandapani S, Lan P, Beeler AB, Beischel S, Abbas A, Roth BL, Porco JA, Panek JS. Convergent synthesis of complex diketopiperazines derived from pipecolic acid scaffolds and parallel screening against GPCR targets. J Org Chem. 2006 Nov 10; 71(23):8934-45. PMID: 17081025.
    View in: PubMed
  110. Yeager AR, Min GK, Porco JA, Schaus SE. Exploring skeletal diversity via ring contraction of glycal-derived scaffolds. Org Lett. 2006 Oct 26; 8(22):5065-8. PMID: 17048844.
    View in: PubMed
  111. Zhu J, Porco JA. Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products. Org Lett. 2006 Oct 26; 8(22):5169-71. PMID: 17048870.
    View in: PubMed
  112. Porco JA, Su S, Lei X, Bardhan S, Rychnovsky SD. Total synthesis and structure assignment of (+)-hexacyclinol. Angew Chem Int Ed Engl. 2006 Sep 4; 45(35):5790-2. PMID: 16871643.
    View in: PubMed
  113. Kleinke AS, Li C, Rabasso N, Porco JA. Total synthesis of the interleukin-1beta converting enzyme inhibitor EI-1941-2 using tandem oxa-electrocyclization/oxidation1. Org Lett. 2006 Jun 22; 8(13):2847-50. PMID: 16774272.
    View in: PubMed
  114. Gerard B, Sangji S, O'Leary DJ, Porco JA. Enantioselective photocycloaddition mediated by chiral Brønsted acids: asymmetric synthesis of the rocaglamides. J Am Chem Soc. 2006 Jun 21; 128(24):7754-5. PMID: 16771486.
    View in: PubMed
  115. Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab. 2006 Jun; 3(6):417-27. PMID: 16753577.
    View in: PubMed
  116. Bardhan S, Schmitt DC, Porco JA. Total synthesis and stereochemical assignment of the spiroisoxazoline natural product (+)-calafianin. Org Lett. 2006 Mar 2; 8(5):927-30. PMID: 16494476.
    View in: PubMed
  117. Helton ME, Maiti D, Zakharov LN, Rheingold AL, Porco JA, Karlin KD. A mu-eta2:eta2-disulfide dicopper(II) complex from reaction of S8 with a copper(I) precursor: reactivity of the bound disulfur moiety. Angew Chem Int Ed Engl. 2006 Feb 6; 45(7):1138-41. PMID: 16385608.
    View in: PubMed
  118. Zaarur N, Gabai VL, Porco JA, Calderwood S, Sherman MY. Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res. 2006 Feb 1; 66(3):1783-91. PMID: 16452239.
    View in: PubMed
  119. Liang MC, Bardhan S, Pace EA, Rosman D, Beutler JA, Porco JA, Gilmore TD. Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity. Biochem Pharmacol. 2006 Feb 28; 71(5):634-45. PMID: 16360644.
    View in: PubMed
  120. Liang MC, Bardhan S, Porco JA, Gilmore TD. The synthetic epoxyquinoids jesterone dimer and epoxyquinone A monomer induce apoptosis and inhibit REL (human c-Rel) DNA binding in an IkappaBalpha-deficient diffuse large B-cell lymphoma cell line. Cancer Lett. 2006 Sep 8; 241(1):69-78. PMID: 16289774.
    View in: PubMed
  121. Kesavan S, Su Q, Shao J, Porco JA, Panek JS. Enantioselective synthesis of linear polypropionate arrays using anthracene-tagged organosilanes. Org Lett. 2005 Sep 29; 7(20):4435-8. PMID: 16178552.
    View in: PubMed
  122. Beeler AB, Acquilano DE, Su Q, Yan F, Roth BL, Panek JS, Porco JA. Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters. J Comb Chem. 2005 Sep-Oct; 7(5):673-81. PMID: 16153061.
    View in: PubMed
  123. Lei X, Zaarur N, Sherman MY, Porco JA. Stereocontrolled synthesis of a complex library via elaboration of angular epoxyquinol scaffolds. J Org Chem. 2005 Aug 5; 70(16):6474-83. PMID: 16050712.
    View in: PubMed
  124. Li C, Porco JA. Synthesis of epoxyquinol A and related molecules: probing chemical reactivity of epoxyquinol dimers and 2H-pyran precursors. J Org Chem. 2005 Jul 22; 70(15):6053-65. PMID: 16018703.
    View in: PubMed
  125. Han C, Lee JP, Lobkovsky E, Porco JA. Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes. J Am Chem Soc. 2005 Jul 20; 127(28):10039-44. PMID: 16011366.
    View in: PubMed
  126. Zhu J, Grigoriadis NP, Lee JP, Porco JA. Synthesis of the azaphilones using copper-mediated enantioselective oxidative dearomatization. J Am Chem Soc. 2005 Jul 6; 127(26):9342-3. PMID: 15984841.
    View in: PubMed
  127. Su S, Acquilano DE, Arumugasamy J, Beeler AB, Eastwood EL, Giguere JR, Lan P, Lei X, Min GK, Yeager AR, Zhou Y, Panek JS, Snyder JK, Schaus SE, Porco JA. Convergent synthesis of a complex oxime library using chemical domain shuffling. Org Lett. 2005 Jun 23; 7(13):2751-4. PMID: 15957938.
    View in: PubMed
  128. Beeler AB, Schaus SE, Porco JA. Chemical library synthesis using convergent approaches. Curr Opin Chem Biol. 2005 Jun; 9(3):277-84. PMID: 15939329.
    View in: PubMed
  129. Wang X, Porco JA. Synthesis of the tetracyclic core of the tetrapetalones through transannular oxidative [4+3] cyclization. Angew Chem Int Ed Engl. 2005 May 13; 44(20):3067-71. PMID: 15832389.
    View in: PubMed
  130. Shen R, Inoue T, Forgac M, Porco JA. Synthesis of photoactivatable acyclic analogues of the lobatamides. J Org Chem. 2005 Apr 29; 70(9):3686-92. PMID: 15845008.
    View in: PubMed
  131. Gerard B, Jones Ii G, Porco JA. A biomimetic approach to the rocaglamides employing photogeneration of oxidopyryliums derived from 3-hydroxyflavones. J Am Chem Soc. 2004 Oct 27; 126(42):13620-1. PMID: 15493911.
    View in: PubMed
  132. Wang X, Bowman EJ, Bowman BJ, Porco JA. Total synthesis of the salicylate enamide macrolide oximidine III: application of relay ring-closing metathesis. Angew Chem Int Ed Engl. 2004 Jul 5; 43(27):3601-5. PMID: 15293258.
    View in: PubMed
  133. Lei X, Porco JA. Synthesis of a polymer-supported anthracene and its application as a dienophile scavenger. Org Lett. 2004 Mar 4; 6(5):795-8. PMID: 14986977.
    View in: PubMed
  134. Zhu J, Germain AR, Porco JA. Synthesis of azaphilones and related molecules by employing cycloisomerization of o-alkynylbenzaldehydes. Angew Chem Int Ed Engl. 2004 Feb 27; 43(10):1239-43. PMID: 14991787.
    View in: PubMed
  135. Li C, Porco JA. Synthesis of the epoxyquinol dimer RKB-3564 D: utilization of an alkoxysilanol to promote [4 + 4] dimerization. J Am Chem Soc. 2004 Feb 11; 126(5):1310-1. PMID: 14759167.
    View in: PubMed
  136. Han C, Shen R, Su S, Porco JA. Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801. Org Lett. 2004 Jan 8; 6(1):27-30. PMID: 14703342.
    View in: PubMed
  137. Lan P, Berta D, Porco JA, South MS, Parlow JJ. Polymer-assisted solution-phase (PASP) Suzuki couplings employing an anthracene-tagged palladium catalyst. J Org Chem. 2003 Dec 12; 68(25):9678-86. PMID: 14656094.
    View in: PubMed
  138. Lei X, Johnson RP, Porco JA. Total synthesis of the ubiquitin-activating enzyme inhibitor (+)-panepophenanthrin. Angew Chem Int Ed Engl. 2003 Aug 25; 42(33):3913-7. PMID: 12949867.
    View in: PubMed
  139. Shen R, Lin CT, Bowman EJ, Bowman BJ, Porco JA. Lobatamide C: total synthesis, stereochemical assignment, preparation of simplified analogues, and V-ATPase inhibition studies. J Am Chem Soc. 2003 Jul 2; 125(26):7889-901. PMID: 12823009.
    View in: PubMed
  140. Liang MC, Bardhan S, Li C, Pace EA, Porco JA, Gilmore TD. Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase. Mol Pharmacol. 2003 Jul; 64(1):123-31. PMID: 12815168.
    View in: PubMed
  141. Su Q, Beeler AB, Lobkovsky E, Porco JA, Panek JS. Stereochemical diversity through cyclodimerization: synthesis of polyketide-like macrodiolides. Org Lett. 2003 Jun 12; 5(12):2149-52. PMID: 12790551.
    View in: PubMed
  142. Wang X, Porco JA. Total synthesis of the salicylate enamide macrolide oximidine II. J Am Chem Soc. 2003 May 21; 125(20):6040-1. PMID: 12785818.
    View in: PubMed
  143. Li C, Johnson RP, Porco JA. Total synthesis of the quinone epoxide dimer (+)-torreyanic acid: application of a biomimetic oxidation/electrocyclization/Diels-Alder dimerization cascade. J Am Chem Soc. 2003 Apr 30; 125(17):5095-106. PMID: 12708860.
    View in: PubMed
  144. Li C, Bardhan S, Pace EA, Liang MC, Gilmore TD, Porco JA. Angiogenesis inhibitor epoxyquinol a: total synthesis and inhibition of transcription factor NF-kappaB. Org Lett. 2002 Sep 19; 4(19):3267-70. PMID: 12227765.
    View in: PubMed
  145. Shen R, Lin CT, Bowman EJ, Bowman BJ, Porco JA. Synthesis and V-ATPase inhibition of simplified lobatamide analogues. Org Lett. 2002 Sep 5; 4(18):3103-6. PMID: 12201727.
    View in: PubMed
  146. Shen R, Lin CT, Porco JA. Total synthesis and stereochemical assignment of the salicylate antitumor macrolide lobatamide C(1). J Am Chem Soc. 2002 May 22; 124(20):5650-1. PMID: 12010033.
    View in: PubMed
  147. Troast DM, Porco JA. Studies toward the synthesis of (-)-zampanolide: preparation of N-acyl hemiaminal model systems. Org Lett. 2002 Mar 21; 4(6):991-4. PMID: 11893204.
    View in: PubMed
  148. Kulkarni BA, Roth GP, Lobkovsky E, Porco JA. Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold. J Comb Chem. 2002 Jan-Feb; 4(1):56-72. PMID: 11831883.
    View in: PubMed
  149. Wang X, Porco JA. Modification of C-terminal peptides to form peptide enamides: synthesis of chondriamides A and C. J Org Chem. 2001 Nov 30; 66(24):8215-21. PMID: 11722228.
    View in: PubMed
  150. Li C, Pace EA, Liang MC, Lobkovsky E, Gilmore TD, Porco JA. Total synthesis of the NF-kappa B inhibitor (-)-cycloepoxydon: utilization of tartrate-mediated nucleophilic epoxidation. J Am Chem Soc. 2001 Nov 14; 123(45):11308-9. PMID: 11697981.
    View in: PubMed
  151. Hu Y, Li C, Kulkarni BA, Strobel G, Lobkovsky E, Torczynski RM, Porco JA. Exploring chemical diversity of epoxyquinoid natural products: synthesis and biological activity of (-)-jesterone and related molecules. Org Lett. 2001 May 31; 3(11):1649-52. PMID: 11405677.
    View in: PubMed
  152. Wang X, Parlow JJ, Porco JA. Parallel synthesis and purification using anthracene-tagged substrates. Org Lett. 2000 Nov 2; 2(22):3509-12. PMID: 11082021.
    View in: PubMed
  153. Porco JA. Organic synthesis using chemical tags: the third Leg of parallel synthesis. Comb Chem High Throughput Screen. 2000 Apr; 3(2):93-102. PMID: 10788579.
    View in: PubMed
  154. Porco JA, Labadie JW. Polymer supports for streamlined organic synthesis. Biotechnol Bioeng. 2000; 71(1):1-2. PMID: 10629529.
    View in: PubMed
  155. Yun YK, Leung SS, Porco JA. Streamlined synthesis of substituted 2-aminothiazoles using tandem precipitative and polymer-assisted reactions. Biotechnol Bioeng. 2000; 71(1):9-18. PMID: 10629531.
    View in: PubMed
  156. Deegan TL, Nitz TJ, Cebzanov D, Pufko DE, Porco JA. Parallel synthesis of 1,2,4-oxadiazoles using CDI activation. Bioorg Med Chem Lett. 1999 Jan 18; 9(2):209-12. PMID: 10021930.
    View in: PubMed
  157. Porco JA, Deegan T, Devonport W, Gooding OW, Heisler K, Labadie JW, Newcomb B, Nguyen C, van Eikeren P, Wong J, Wright P. Automated chemical synthesis: from resins to instruments. Mol Divers. 1997; 2(4):197-206. PMID: 9249755.
    View in: PubMed
  158. Schreiber SL, Kelly SE, Porco JA, Sammakia T, Suh EM. Structural and synthetic studies of the spore germination autoinhibitor, gloeosporone. J Am Chem Soc. 1988 Aug 1; 110(18):6210-8. PMID: 22148801.
    View in: PubMed
John's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
BU Co-Authors
_
Similar BU People
_
Same Department