John A. Porco, PhD
Professor
Boston University College of Arts and Sciences
Dept of Chemistry

PhD, Harvard University
DEng, College of The Holy Cross
MS, Yale University



John Porco investigates chemical syntheses of complex molecules and synthesis of complex chemical libraries of novel structural types. John joined the Department of Chemistry at Boston University in 1999 after a successful career in industry and was rapidly promoted to Professor of Chemistry in September 2004.

Research in the Porco Group is focused in two major areas: the development of new synthetic methodologies for efficient chemical synthesis of complex molecules and synthesis of complex chemical libraries, the latter conducted at the Boston University Center for Molecular Discovery. Synthetic methodologies developed in the Porco Laboratory include copper (I)-mediated formation of enamides, oxa-electrocyclization/dimerization of dienals enroute to complex epoxyquinoids; enantioselective oxidative dearomatization using chiral copper complexes and molecular oxygen; photocycloaddition using oxidopyryliums enroute to the rocaglamides and related natural products, and catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes.

-Dearomatization Strategies in Complex Synthesis aim to utilize aromatic scaffolds as starting materials as precursors to complex natural products.

-Faculty Profile Scientific Image Porco 1Biomimetic Synthesis Approaches involve development of methodologies to test plausible biosyntheses of complex natural products and derivatives.

-New Reaction Discovery is done in conjunction with the BU-CMD and aims to discover transformations leading to novel chemotypes.

Techniques & Resources:

-Organic Synthesis techniques are used and include modern methods for synthesis, purification, and analysis of organic molecules
.
-Boston University Center for Molecular Discovery (BU-CMD) is an NIH-funded Center at Boston University which focuses on development of new methodologies for the synthesis of complex chemical libraries.

Professor
Boston University School of Medicine
Department of Pharmacology & Experimental Therapeutics




Chemical Sythesis of Complex natural Products for Translational Science
05/01/2016 - 04/30/2018 (PI)
NIH/National Institute of General Medical Sciences
5R35GM118173-02

Development of Novel APP Dimerization Inhibitors that Lower A-beta Levels
09/01/2015 - 09/06/2017 (SP Co-PI of Sub-Project / SP)
PI: Carmela R. Abraham, PhD
Cure Alzheimer's Fund

Center for Molecular Discovery (CMD): A Small Molecule Resource for Biomedical Research
07/01/2015 - 06/30/2017 (PI)
NIH/National Institute of General Medical Sciences
5R24GM111625-02

HCV Entry: Mechanisms and Therapeutics
09/26/2016 - 05/31/2017 (PI)
SRI International NIH NIDDK
2R01DK088787-06A1

Inhibiting the Heat Shock Factor 1-Regulated Transcriptional Program in Cancers
04/01/2013 - 03/31/2017 (PI)
Whitehead Institute for Biomedical Research NIH NCI
5R01CA175744-03

Chemical Synthesis of Bioactive Flavonoid and Xanthone-Derived Natural Products
02/01/2012 - 01/31/2017 (PI)
NIH/National Institute of General Medical Sciences
5R01GM099920-04

Target validation and development of drug discovery platform for TREM2/TYROBP signaling pathway modular
11/01/2014 - 10/31/2016 (Co-PI)
PI: Tsuneya Ikezu, MD, PhD
Massachusetts Neuroscience Consortium

Biomimetic Synthesis of Complex Natural Products
09/01/2014 - 07/31/2016 (PI)
NIH/National Institute of General Medical Sciences
5R01GM073855-10

Biomimetic Synthesis of Macrocarpal Natural Products and their Biological Evaluation (NRSA)
09/17/2012 - 02/20/2015 (PI)
NIH/National Cancer Institute
5F32CA171792-03

COMPLEX CHEMOTYPES: DISCOVERY, METHODOLOGY, AND LIBRARY EXPANSION - LSC
09/01/2010 - 08/31/2014 (PI)
NIH/National Institute of General Medical Sciences
5P50GM067041-10

Showing 10 of 12 results. Show All Results



Yr Title Project-Sub Proj Pubs
2016 Chemical Synthesis of Complex Natural Products for Translational Science 1R35GM118173-01
2016 Center for Molecular Discovery (CMD): A Small Molecule Resource for Biomedical Research 5R24GM111625-02 2
2015 Inhibiting the heat shock factor 1-regulated transcriptional program in cancer 5R01CA175744-03 2
2015 Chemical Synthesis of Bioactive Flavonoid and Xanthone-Derived Natural Products 5R01GM099920-04 9
2015 Biomimetic Synthesis of Complex Natural Products 5R01GM073855-10 41
2014 Inhibiting the heat shock factor 1-regulated transcriptional program in cancer 5R01CA175744-02 2
2014 Chemical Synthesis of Bioactive Flavonoid and Xanthone-Derived Natural Products 5R01GM099920-03 9
2014 Biomimetic Synthesis of Complex Natural Products 2R01GM073855-09 41
2013 Inhibiting the heat shock factor 1-regulated transcriptional program in cancer 1R01CA175744-01 2
2013 Chemical Synthesis of Bioactive Flavonoid and Xanthone-Derived Natural Products 5R01GM099920-02 9
Showing 10 of 68 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA, Ghobrial IM. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10; 9(389).View Related Profiles. PMID: 28490664.
  2. Boyce JH, Eschenbrenner-Lux V, Porco JA. Syntheses of (+)-30-epi-, (-)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations. J Am Chem Soc. 2016 Nov 09; 138(44):14789-14797. PMID: 27744695.
  3. Hayashi M, Brown LE, Porco JA. Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes. European J Org Chem. 2016 Oct; 2016(28):4800-4804. PMID: 28082832; DOI: 10.1002/ejoc.201601003;.
  4. Ingham OJ, Paranal RM, Smith WB, Escobar RA, Yueh H, Snyder T, Porco JA, Bradner JE, Beeler AB. Development of a Potent and Selective HDAC8 Inhibitor. ACS Med Chem Lett. 2016 Oct 13; 7(10):929-932.View Related Profiles. PMID: 27774131.
  5. Wang W, Cencic R, Whitesell L, Pelletier J, Porco JA. Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition. Chemistry. 2016 Aug 16; 22(34):12006-10. PMID: 27338157; DOI: 10.1002/chem.201602953;.
  6. Chu J, Galicia-Vázquez G, Cencic R, Mills JR, Katigbak A, Porco JA, Pelletier J. CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A. Cell Rep. 2016 Jun 14; 15(11):2340-7. PMID: 27239032; DOI: 10.1016/j.celrep.2016.05.005;.
  7. Kärkäs MD, Porco JA, Stephenson CR. Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. Chem Rev. 2016 Sep 14; 116(17):9683-747. PMID: 27120289; DOI: 10.1021/acs.chemrev.5b00760;.
  8. Bhattacharya B, Chatterjee S, Devine WG, Kobzik L, Beeler AB, Porco JA, Kramnik I. Fine-tuning of macrophage activation using synthetic rocaglate derivatives. Sci Rep. 2016 Apr 18; 6:24409.View Related Profiles. PMID: 27086720; PMCID: PMC4834551; DOI: 10.1038/srep24409;.
  9. Gandin V, Masvidal L, Hulea L, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA, St-Pierre J, Pelletier J, Larsson O, Topisirovic I. nanoCAGE reveals 5'' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs. Genome Res. 2016 05; 26(5):636-48. PMID: 26984228; PMCID: PMC4864462; DOI: 10.1101/gr.197566.115;.
  10. Qi C, Xiong Y, Eschenbrenner-Lux V, Cong H, Porco JA. Asymmetric Syntheses of the Flavonoid Diels-Alder Natural Products Sanggenons C and O. J Am Chem Soc. 2016 Jan 27; 138(3):798-801. PMID: 26735066; PMCID: PMC4863937; DOI: 10.1021/jacs.5b12778;.
Showing 10 of 160 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 160 publications over 21 distinct years, with a maximum of 19 publications in 2011

YearPublications
19881
19971
19992
20004
20013
20025
20037
20046
200512
200611
200715
20085
20097
201011
201119
201214
20138
201413
20156
20169
20171
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