Keywords
Last Name

Catherine E. Costello, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address670 Albany St Biosquare III
Boston MA 02118
Phone(617) 638-6490
ORCID ORCID Icon0000-0003-1594-5122
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

TitleResearch Professor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics

 Awards and Honors

Start-EndDescription
2010American Chemical Society: Field and Franklin Award
2013Boston University: William Fairfield Warren Distinguished Professor
 Research Expertise & Professional Interests
Catherine Costello came to Boston University in 1994. That year she established the Center for Biomedical Mass Spectrometry, which has become an internationally recognized research center. She holds her primary appointment in the MED Biochemistry Department, with secondary appointments in the Department of Physiology & Biophysics and the Department of Chemistry. Her research, which focuses on determining the structures and functions of biologically important polymers, has revolutionized an important area of biochemistry by providing insights into the structures of molecules responsible for human disease. She is the author or co-author of more than 300 scientific papers, serves on a number of editorial boards of major journals, and has received numerous awards and honors, including the 2010 Field and Franklin Award from the American Chemical Society, one of the highest honors in her field.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. de Souza EE, Meirelles GV, Godoy BB, Perez AM, Smetana JH, Doxsey SJ, McComb ME, Costello CE, Whelan SA, Kobarg J. Characterization of the Human NEK7 Interactome Suggests Catalytic and Regulatory Properties Distinct from Those of NEK6. J Proteome Res. 2014 Sep 5; 13(9):4074-90.
    View in: PubMed
  2. Jiang J, Tian F, Cai Y, Qian X, Costello CE, Ying W. Site-specific qualitative and quantitative analysis of the N- and O-glycoforms in recombinant human erythropoietin. Anal Bioanal Chem. 2014 Oct; 406(25):6265-74.
    View in: PubMed
  3. Zhou Y, Park H, Kim P, Jiang Y, Costello CE. Surface Oxidation under Ambient Air-Not Only a Fast and Economical Method to Identify Double Bond Positions in Unsaturated Lipids But Also a Reminder of Proper Lipid Processing. Anal Chem. 2014 Jun 17; 86(12):5697-705.
    View in: PubMed
  4. Huang Y, Pu Y, Yu X, Costello CE, Lin C. Mechanistic study on electron capture dissociation of the oligosaccharide-mg(2+) complex. J Am Soc Mass Spectrom. 2014 Aug; 25(8):1451-60.
    View in: PubMed
  5. Bourgoin-Voillard S, Leymarie N, Costello CE. Top-down tandem mass spectrometry on RNase A and B using a Qh/FT-ICR hybrid mass spectrometer. Proteomics. 2014 May; 14(10):1174-84.
    View in: PubMed
  6. York WS, Agravat S, Aoki-Kinoshita KF, McBride R, Campbell MP, Costello CE, Dell A, Feizi T, Haslam SM, Karlsson N, Khoo KH, Kolarich D, Liu Y, Novotny M, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Struwe WB, Tiemeyer M, Wells L, Zaia J, Kettner C. MIRAGE: The minimum information required for a glycomics experiment. Glycobiology. 2014 May; 24(5):402-6.
    View in: PubMed
  7. Gault J, Malosse C, Machata S, Millien C, Podglajen I, Ploy MC, Costello CE, Duménil G, Chamot-Rooke J. Complete posttranslational modification mapping of pathogenic Neisseria meningitidis pilins requires top-down mass spectrometry. Proteomics. 2014 May; 14(10):1141-51.
    View in: PubMed
  8. Park H, Zhou Y, Costello CE. Direct analysis of sialylated or sulfated glycosphingolipids and other polar and neutral lipids using TLC-MS interfaces. J Lipid Res. 2014 Apr; 55(4):773-81.
    View in: PubMed
  9. Behring JB, Kumar V, Whelan SA, Chauhan P, Siwik DA, Costello CE, Colucci WS, Cohen RA, McComb ME, Bachschmid MM. Does reversible cysteine oxidation link the Western diet to cardiac dysfunction? FASEB J. 2014 May; 28(5):1975-87.
    View in: PubMed
  10. Ji Y, Leymarie N, Haeussler DJ, Bachschmid MM, Costello CE, Lin C. Direct detection of s-palmitoylation by mass spectrometry. Anal Chem. 2013 Dec 17; 85(24):11952-9.
    View in: PubMed
  11. Hartsough EJ, Meyer RD, Chitalia V, Jiang Y, Marquez VE, Zhdanova IV, Weinberg J, Costello CE, Rahimi N. Lysine Methylation Promotes VEGFR-2 Activation and Angiogenesis. Sci Signal. 2013; 6(304):ra104.
    View in: PubMed
  12. Huang Y, Yu X, Mao Y, Costello CE, Zaia J, Lin C. De novo sequencing of heparan sulfate oligosaccharides by electron-activated dissociation. Anal Chem. 2013 Dec 17; 85(24):11979-86.
    View in: PubMed
  13. Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89.
    View in: PubMed
  14. Yu X, Jiang Y, Chen Y, Huang Y, Costello CE, Lin C. Detailed glycan structural characterization by electronic excitation dissociation. Anal Chem. 2013 Nov 5; 85(21):10017-21.
    View in: PubMed
  15. Kehasse A, Rich CB, Lee A, McComb ME, Costello CE, Trinkaus-Randall V. Epithelial wounds induce differential phosphorylation changes in response to purinergic and EGF receptor activation. Am J Pathol. 2013 Dec; 183(6):1841-52.
    View in: PubMed
  16. Bushkin GG, Motari E, Carpentieri A, Dubey JP, Costello CE, Robbins PW, Samuelson J. Evidence for a structural role for acid-fast lipids in oocyst walls of Cryptosporidium, Toxoplasma, and Eimeria. MBio. 2013; 4(5):e00387-13.
    View in: PubMed
  17. Leo G, Altucci C, Bourgoin-Voillard S, Gravagnuolo AM, Esposito R, Marino G, Costello CE, Velotta R, Birolo L. Ultraviolet laser-induced cross-linking in peptides. Rapid Commun Mass Spectrom. 2013 Jul 30; 27(14):1660-8.
    View in: PubMed
  18. Han L, Costello CE. Mass spectrometry of glycans. Biochemistry (Mosc). 2013 Jul; 78(7):710-20.
    View in: PubMed
  19. Smith BW, Rozelle SS, Leung A, Ubellacker J, Parks A, Nah SK, French D, Gadue P, Monti S, Chui DH, Steinberg MH, Frelinger AL, Michelson AD, Theberge R, McComb ME, Costello CE, Kotton DN, Mostoslavsky G, Sherr DH, Murphy GJ. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood. 2013 Jul 18; 122(3):376-85.
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  20. Drouin EE, Seward RJ, Strle K, McHugh G, Katchar K, Londoño D, Yao C, Costello CE, Steere AC. A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease. Arthritis Rheum. 2013 Jan; 65(1):186-96.
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  21. Bushkin GG, Motari E, Magnelli P, Gubbels MJ, Dubey JP, Miska KB, Bullitt E, Costello CE, Robbins PW, Samuelson J. ß-1,3-glucan, which can be targeted by drugs, forms a trabecular scaffold in the oocyst walls of Toxoplasma and Eimeria. MBio. 2012; 3(5).
    View in: PubMed
  22. Chinnapen DJ, Hsieh WT, te Welscher YM, Saslowsky DE, Kaoutzani L, Brandsma E, D'Auria L, Park H, Wagner JS, Drake KR, Kang M, Benjamin T, Ullman MD, Costello CE, Kenworthy AK, Baumgart T, Massol RH, Lencer WI. Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1. Dev Cell. 2012 Sep 11; 23(3):573-86.
    View in: PubMed
  23. Yu X, Huang Y, Lin C, Costello CE. Energy-dependent electron activated dissociation of metal-adducted permethylated oligosaccharides. Anal Chem. 2012 Sep 4; 84(17):7487-94.
    View in: PubMed
  24. Lu Z, Madico G, Roche MI, Wang Q, Hui JH, Perkins HM, Zaia J, Costello CE, Sharon J. Protective B-cell epitopes of Francisella tularensis O-polysaccharide in a mouse model of respiratory tularaemia. Immunology. 2012 Jul; 136(3):352-60.
    View in: PubMed
  25. Li X, Yu X, Costello CE, Lin C, O'Connor PB. Top-down study of ß2-microglobulin deamidation. Anal Chem. 2012 Jul 17; 84(14):6150-7.
    View in: PubMed
  26. Wang Q, Shi X, Leymarie N, Madico G, Sharon J, Costello CE, Zaia J. A typical preparation of Francisella tularensis O-antigen yields a mixture of three types of saccharides. Biochemistry. 2011 Dec 20; 50(50):10941-50.
    View in: PubMed
  27. Legrain P, Aebersold R, Archakov A, Bairoch A, Bala K, Beretta L, Bergeron J, Borchers CH, Corthals GL, Costello CE, Deutsch EW, Domon B, Hancock W, He F, Hochstrasser D, Marko-Varga G, Salekdeh GH, Sechi S, Snyder M, Srivastava S, Uhlén M, Wu CH, Yamamoto T, Paik YK, Omenn GS. The human proteome project: current state and future direction. Mol Cell Proteomics. 2011 Jul; 10(7):M111.009993.
    View in: PubMed
  28. Han L, Costello CE. Electron transfer dissociation of milk oligosaccharides. J Am Soc Mass Spectrom. 2011 Jun; 22(6):997-1013.
    View in: PubMed
  29. Szmola R, Bence M, Carpentieri A, Szabó A, Costello CE, Samuelson J, Sahin-Tóth M. Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2. J Biol Chem. 2011 Jan 21; 286(3):1819-27.
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  30. Seward RJ, Drouin EE, Steere AC, Costello CE. Peptides presented by HLA-DR molecules in synovia of patients with rheumatoid arthritis or antibiotic-refractory Lyme arthritis. Mol Cell Proteomics. 2011 Mar; 10(3):M110.002477.
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  31. Zee RS, Yoo CB, Pimentel DR, Perlman DH, Burgoyne JR, Hou X, McComb ME, Costello CE, Cohen RA, Bachschmid MM. Redox regulation of sirtuin-1 by S-glutathiolation. Antioxid Redox Signal. 2010 Oct 1; 13(7):1023-32.
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  32. Ren R, Hong Z, Gong H, Laporte K, Skinner M, Seldin DC, Costello CE, Connors LH, Trinkaus-Randall V. Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils. J Biol Chem. 2010 Nov 26; 285(48):37672-82.
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  33. Carpentieri A, Ratner DM, Ghosh SK, Banerjee S, Bushkin GG, Cui J, Lubrano M, Steffen M, Costello CE, O'Keefe B, Robbins PW, Samuelson J. The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites. Eukaryot Cell. 2010 Nov; 9(11):1661-8.
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  34. Chatterjee A, Carpentieri A, Ratner DM, Bullitt E, Costello CE, Robbins PW, Samuelson J. Giardia cyst wall protein 1 is a lectin that binds to curled fibrils of the GalNAc homopolymer. PLoS Pathog. 2010; 6(8):e1001059.
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  35. Palaima E, Leymarie N, Stroud D, Mizanur RM, Hodgkin J, Gravato-Nobre MJ, Costello CE, Cipollo JF. The Caenorhabditis elegans bus-2 mutant reveals a new class of O-glycans affecting bacterial resistance. J Biol Chem. 2010 Jun 4; 285(23):17662-72.
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  36. Li X, Lin C, Han L, Costello CE, O'Connor PB. Charge remote fragmentation in electron capture and electron transfer dissociation. J Am Soc Mass Spectrom. 2010 Apr; 21(4):646-56.
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  37. Staples GO, Naimy H, Yin H, Kileen K, Kraiczek K, Costello CE, Zaia J. Improved hydrophilic interaction chromatography LC/MS of heparinoids using a chip with postcolumn makeup flow. Anal Chem. 2010 Jan 15; 82(2):516-22.
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  38. Ebbel EN, Leymarie N, Schiavo S, Sharma S, Gevorkian S, Hersch S, Matson WR, Costello CE. Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry. Anal Biochem. 2010 Apr 15; 399(2):152-61.
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  39. Wada Y, Dell A, Haslam SM, Tissot B, Canis K, Azadi P, Bäckström M, Costello CE, Hansson GC, Hiki Y, Ishihara M, Ito H, Kakehi K, Karlsson N, Hayes CE, Kato K, Kawasaki N, Khoo KH, Kobayashi K, Kolarich D, Kondo A, Lebrilla C, Nakano M, Narimatsu H, Novak J, Novotny MV, Ohno E, Packer NH, Palaima E, Renfrow MB, Tajiri M, Thomsson KA, Yagi H, Yu SY, Taniguchi N. Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1. Mol Cell Proteomics. 2010 Apr; 9(4):719-27.
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  40. Bhatia VN, Perlman DH, Costello CE, McComb ME. Software tool for researching annotations of proteins: open-source protein annotation software with data visualization. Anal Chem. 2009 Dec 1; 81(23):9819-23.
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  41. Ying W, Perlman DH, Li L, Théberge R, Costello CE, McComb ME. Highly efficient and selective enrichment of peptide subsets combining fluorous chemistry with reversed-phase chromatography. Rapid Commun Mass Spectrom. 2009 Dec; 23(24):4019-30.
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  42. Connors LH, Prokaeva T, Lim A, Théberge R, Falk RH, Doros G, Berg A, Costello CE, O'Hara C, Seldin DC, Skinner M. Cardiac amyloidosis in African Americans: comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosis. Am Heart J. 2009 Oct; 158(4):607-14.
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  43. Young DC, Kasmar A, Moraski G, Cheng TY, Walz AJ, Hu J, Xu Y, Endres GW, Uzieblo A, Zajonc D, Costello CE, Miller MJ, Moody DB. Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures. J Biol Chem. 2009 Sep 11; 284(37):25087-96.
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  44. Rex S, Beaulieu LM, Perlman DH, Vitseva O, Blair PS, McComb ME, Costello CE, Freedman JE. Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release. Thromb Haemost. 2009 Jul; 102(1):97-110.
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  45. Romesser PB, Perlman DH, Faller DV, Costello CE, McComb ME, Denis GV. Development of a malignancy-associated proteomic signature for diffuse large B-cell lymphoma. Am J Pathol. 2009 Jul; 175(1):25-35.
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  46. Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, Barral D, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB. CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J Exp Med. 2009 Jun 8; 206(6):1409-22.
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  47. Makkinje A, Near RI, Infusini G, Vanden Borre P, Bloom A, Cai D, Costello CE, Lerner A. AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. Cell Signal. 2009 Sep; 21(9):1423-35.
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  48. Jones KL, Seward RJ, Ben-Menachem G, Glickstein LJ, Costello CE, Steere AC. Strong IgG antibody responses to Borrelia burgdorferi glycolipids in patients with Lyme arthritis, a late manifestation of the infection. Clin Immunol. 2009 Jul; 132(1):93-102.
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  49. Perlman DH, Bauer SM, Ashrafian H, Bryan NS, Garcia-Saura MF, Lim CC, Fernandez BO, Infusini G, McComb ME, Costello CE, Feelisch M. Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach. Circ Res. 2009 Mar 27; 104(6):796-804.
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  50. Staples GO, Bowman MJ, Costello CE, Hitchcock AM, Lau JM, Leymarie N, Miller C, Naimy H, Shi X, Zaia J. A chip-based amide-HILIC LC/MS platform for glycosaminoglycan glycomics profiling. Proteomics. 2009 Feb; 9(3):686-95.
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  51. Wang Y, Meriin AB, Zaarur N, Romanova NV, Chernoff YO, Costello CE, Sherman MY. Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery. FASEB J. 2009 Feb; 23(2):451-63.
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  52. Kilcoyne M, Shah M, Gerlach JQ, Bhavanandan V, Nagaraj V, Smith AD, Fujiyama K, Sommer U, Costello CE, Olszewski N, Joshi L. O-glycosylation of protein subpopulations in alcohol-extracted rice proteins. J Plant Physiol. 2009 Feb 15; 166(3):219-32.
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  53. Singh BN, Hayes GR, Lucas JJ, Sommer U, Viseux N, Mirgorodskaya E, Trifonova RT, Sassi RR, Costello CE, Fichorova RN. Structural details and composition of Trichomonas vaginalis lipophosphoglycan in relevance to the epithelial immune function. Glycoconj J. 2009 Jan; 26(1):3-17.
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  54. Lavatelli F, Perlman DH, Spencer B, Prokaeva T, McComb ME, Théberge R, Connors LH, Bellotti V, Seldin DC, Merlini G, Skinner M, Costello CE. Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue. Mol Cell Proteomics. 2008 Aug; 7(8):1570-83.
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  55. Magnelli P, Cipollo JF, Ratner DM, Cui J, Kelleher D, Gilmore R, Costello CE, Robbins PW, Samuelson J. Unique Asn-linked oligosaccharides of the human pathogen Entamoeba histolytica. J Biol Chem. 2008 Jun 27; 283(26):18355-64.
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  56. Hitchcock AM, Yates KE, Costello CE, Zaia J. Comparative glycomics of connective tissue glycosaminoglycans. Proteomics. 2008 Apr; 8(7):1384-97.
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  57. Kingsbury JS, Laue TM, Klimtchuk ES, Théberge R, Costello CE, Connors LH. The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation. J Biol Chem. 2008 May 2; 283(18):11887-96.
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  58. Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A. Human Proteinpedia enables sharing of human protein data. Nat Biotechnol. 2008 Feb; 26(2):164-7.
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  59. Lim CC, Yang H, Yang M, Wang CK, Shi J, Berg EA, Pimentel DR, Gwathmey JK, Hajjar RJ, Helmes M, Costello CE, Huo S, Liao R. A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility. Biophys J. 2008 May 1; 94(9):3577-89.
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  60. Brennan MR, Costello CE, Maleknia SD, Pettit GR, Erickson KL. Stylopeptide 2, a proline-rich cyclodecapeptide from the sponge Stylotella sp. J Nat Prod. 2008 Mar; 71(3):453-6.
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  61. Connors LH, Jiang Y, Budnik M, Théberge R, Prokaeva T, Bodi KL, Seldin DC, Costello CE, Skinner M. Heterogeneity in primary structure, post-translational modifications, and germline gene usage of nine full-length amyloidogenic kappa1 immunoglobulin light chains. Biochemistry. 2007 Dec 11; 46(49):14259-71.
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  62. Zhao C, Xie B, Chan SY, Costello CE, O'Connor PB. Collisionally activated dissociation and electron capture dissociation provide complementary structural information for branched permethylated oligosaccharides. J Am Soc Mass Spectrom. 2008 Jan; 19(1):138-50.
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  63. Luo X, Cerullo J, Dawli T, Priest C, Haddadin Z, Kim A, Inouye H, Suffoletto BP, Avila RL, Lees JP, Sharma D, Xie B, Costello CE, Kirschner DA. Peripheral myelin of Xenopus laevis: role of electrostatic and hydrophobic interactions in membrane compaction. J Struct Biol. 2008 Apr; 162(1):170-83.
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  64. Costello CE, Contado-Miller JM, Cipollo JF. A glycomics platform for the analysis of permethylated oligosaccharide alditols. J Am Soc Mass Spectrom. 2007 Oct; 18(10):1799-812.
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  65. Altland K, Benson MD, Costello CE, Ferlini A, Hazenberg BP, Hund E, Kristen AV, Linke RP, Merlini G, Salvi F, Saraiva MJ, Singer R, Skinner M, Winter P. Genetic microheterogeneity of human transthyretin detected by IEF. Electrophoresis. 2007 Jun; 28(12):2053-64.
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  66. Pilch PF, Souto RP, Liu L, Jedrychowski MP, Berg EA, Costello CE, Gygi SP. Cellular spelunking: exploring adipocyte caveolae. J Lipid Res. 2007 Oct; 48(10):2103-11.
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  67. Saba JA, McComb ME, Potts DL, Costello CE, Amar S. Proteomic mapping of stimulus-specific signaling pathways involved in THP-1 cells exposed to Porphyromonas gingivalis or its purified components. J Proteome Res. 2007 Jun; 6(6):2211-21.
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  68. Wang Y, Meriin AB, Costello CE, Sherman MY. Characterization of proteins associated with polyglutamine aggregates: a novel approach towards isolation of aggregates from protein conformation disorders. Prion. 2007 Apr-Jun; 1(2):128-35.
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  69. Zaia J, Miller MJ, Seymour JL, Costello CE. The role of mobile protons in negative ion CID of oligosaccharides. J Am Soc Mass Spectrom. 2007 May; 18(5):952-60.
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  70. Kranz C, Ng BG, Sun L, Sharma V, Eklund EA, Miura Y, Ungar D, Lupashin V, Winkel RD, Cipollo JF, Costello CE, Loh E, Hong W, Freeze HH. COG8 deficiency causes new congenital disorder of glycosylation type IIh. Hum Mol Genet. 2007 Apr 1; 16(7):731-41.
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  71. Rosenzweig M, Skinner M, Prokaeva T, Théberge R, Costello C, Drachman BM, Connors LH. A new transthyretin variant (Glu61Gly) associated with cardiomyopathy. Amyloid. 2007 Mar; 14(1):65-71.
    View in: PubMed
  72. Kingsbury JS, Théberge R, Karbassi JA, Lim A, Costello CE, Connors LH. Detailed structural analysis of amyloidogenic wild-type transthyretin using a novel purification strategy and mass spectrometry. Anal Chem. 2007 Mar 1; 79(5):1990-8.
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  73. Perlman DH, Huang H, Dauly C, Costello CE, McComb ME. Coupling of protein HPLC to MALDI-TOF MS using an on-target device for fraction collection, concentration, digestion, desalting, and matrix/analyte cocrystallization. Anal Chem. 2007 Mar 1; 79(5):2058-66.
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  74. Kingsbury JS, Klimtchuk ES, Théberge R, Costello CE, Connors LH. Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretin. Protein Expr Purif. 2007 Jun; 53(2):370-7.
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  75. Wada Y, Azadi P, Costello CE, Dell A, Dwek RA, Geyer H, Geyer R, Kakehi K, Karlsson NG, Kato K, Kawasaki N, Khoo KH, Kim S, Kondo A, Lattova E, Mechref Y, Miyoshi E, Nakamura K, Narimatsu H, Novotny MV, Packer NH, Perreault H, Peter-Katalinic J, Pohlentz G, Reinhold VN, Rudd PM, Suzuki A, Taniguchi N. Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study. Glycobiology. 2007 Apr; 17(4):411-22.
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  76. Odhiambo A, Perlman DH, Huang H, Costello CE, Farber HW, Steinberg MH, McComb ME, Klings ES. Identification of oxidative post-translational modification of serum albumin in patients with idiopathic pulmonary arterial hypertension and pulmonary hypertension of sickle cell anemia. Rapid Commun Mass Spectrom. 2007; 21(14):2195-203.
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  77. McComb ME, Perlman DH, Huang H, Costello CE. Evaluation of an on-target sample preparation system for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in conjunction with normal-flow peptide high-performance liquid chromatography for peptide mass fingerprint analyses. Rapid Commun Mass Spectrom. 2007; 21(1):44-58.
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  78. Sethuraman M, Clavreul N, Huang H, McComb ME, Costello CE, Cohen RA. Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry. Free Radic Biol Med. 2007 Mar 15; 42(6):823-9.
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  79. Monis GF, Schultz C, Ren R, Eberhard J, Costello C, Connors L, Skinner M, Trinkaus-Randall V. Role of endocytic inhibitory drugs on internalization of amyloidogenic light chains by cardiac fibroblasts. Am J Pathol. 2006 Dec; 169(6):1939-52.
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  80. Fichorova RN, Trifonova RT, Gilbert RO, Costello CE, Hayes GR, Lucas JJ, Singh BN. Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells. Infect Immun. 2006 Oct; 74(10):5773-9.
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  81. Hitchcock AM, Yates KE, Shortkroff S, Costello CE, Zaia J. Optimized extraction of glycosaminoglycans from normal and osteoarthritic cartilage for glycomics profiling. Glycobiology. 2007 Jan; 17(1):25-35.
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  82. Mitsi M, Hong Z, Costello CE, Nugent MA. Heparin-mediated conformational changes in fibronectin expose vascular endothelial growth factor binding sites. Biochemistry. 2006 Aug 29; 45(34):10319-28.
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  83. Ghosh S, Seward R, Costello CE, Stollar BD, Huber BT. Autoantibodies from synovial lesions in chronic, antibiotic treatment-resistant Lyme arthritis bind cytokeratin-10. J Immunol. 2006 Aug 15; 177(4):2486-94.
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  84. Madico G, Welsch JA, Lewis LA, McNaughton A, Perlman DH, Costello CE, Ngampasutadol J, Vogel U, Granoff DM, Ram S. The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance. J Immunol. 2006 Jul 1; 177(1):501-10.
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  85. Dauly C, Perlman DH, Costello CE, McComb ME. Protein separation and characterization by np-RP-HPLC followed by intact MALDI-TOF mass spectrometry and peptide mass mapping analyses. J Proteome Res. 2006 Jul; 5(7):1688-700.
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  86. Seymour JL, Costello CE, Zaia J. The influence of sialylation on glycan negative ion dissociation and energetics. J Am Soc Mass Spectrom. 2006 Jun; 17(6):844-54.
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  87. Xie B, Zhou G, Chan SY, Shapiro E, Kong XP, Wu XR, Sun TT, Costello CE. Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia. J Biol Chem. 2006 May 26; 281(21):14644-53.
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  88. Denis GV, McComb ME, Faller DV, Sinha A, Romesser PB, Costello CE. Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. J Proteome Res. 2006 Mar; 5(3):502-11.
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  89. Hitchcock AM, Costello CE, Zaia J. Glycoform quantification of chondroitin/dermatan sulfate using a liquid chromatography-tandem mass spectrometry platform. Biochemistry. 2006 Feb 21; 45(7):2350-61.
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  90. Miller MJ, Costello CE, Malmström A, Zaia J. A tandem mass spectrometric approach to determination of chondroitin/dermatan sulfate oligosaccharide glycoforms. Glycobiology. 2006 Jun; 16(6):502-13.
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  91. Sommer U, Herscovitz H, Welty FK, Costello CE. LC-MS-based method for the qualitative and quantitative analysis of complex lipid mixtures. J Lipid Res. 2006 Apr; 47(4):804-14.
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  92. Wang Y, Berg EA, Feng X, Shen L, Smith T, Costello CE, Zhang YX. Identification of surface-exposed components of MOMP of Chlamydia trachomatis serovar F. Protein Sci. 2006 Jan; 15(1):122-34.
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  93. Jebanathirajah JA, Pittman JL, Thomson BA, Budnik BA, Kaur P, Rape M, Kirschner M, Costello CE, O'Connor PB. Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins. J Am Soc Mass Spectrom. 2005 Dec; 16(12):1985-99.
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  94. Oh SY, Ellenstein A, Chen CD, Hinman JD, Berg EA, Costello CE, Yamin R, Neve RL, Abraham CR. Amyloid precursor protein interacts with notch receptors. J Neurosci Res. 2005 Oct 1; 82(1):32-42.
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  95. Ivleva VB, Sapp LM, O'Connor PB, Costello CE. Ganglioside analysis by thin-layer chromatography matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry. J Am Soc Mass Spectrom. 2005 Sep; 16(9):1552-60.
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  96. Perlman DH, Berg EA, O'connor PB, Costello CE, Hu J. Reverse transcription-associated dephosphorylation of hepadnavirus nucleocapsids. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):9020-5.
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  97. Cipollo JF, Awad AM, Costello CE, Hirschberg CB. N-Glycans of Caenorhabditis elegans are specific to developmental stages. J Biol Chem. 2005 Jul 15; 280(28):26063-72.
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  98. Sommer U, Costello CE, Hayes GR, Beach DH, Gilbert RO, Lucas JJ, Singh BN. Identification of Trichomonas vaginalis cysteine proteases that induce apoptosis in human vaginal epithelial cells. J Biol Chem. 2005 Jun 24; 280(25):23853-60.
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  99. Chung CM, Chiu JD, Connors LH, Gursky O, Lim A, Dykstra AB, Liepnieks J, Benson MD, Costello CE, Skinner M, Walsh MT. Thermodynamic stability of a kappaI immunoglobulin light chain: relevance to multiple myeloma. Biophys J. 2005 Jun; 88(6):4232-42.
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  100. Zajonc DM, Crispin MD, Bowden TA, Young DC, Cheng TY, Hu J, Costello CE, Rudd PM, Dwek RA, Miller MJ, Brenner MB, Moody DB, Wilson IA. Molecular mechanism of lipopeptide presentation by CD1a. Immunity. 2005 Feb; 22(2):209-19.
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  101. Cournoyer JJ, Pittman JL, Ivleva VB, Fallows E, Waskell L, Costello CE, O'Connor PB. Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation. Protein Sci. 2005 Feb; 14(2):452-63.
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  102. Matsunaga I, Bhatt A, Young DC, Cheng TY, Eyles SJ, Besra GS, Briken V, Porcelli SA, Costello CE, Jacobs WR, Moody DB. Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. J Exp Med. 2004 Dec 20; 200(12):1559-69.
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  103. Gudiksen KL, Urbach AR, Gitlin I, Yang J, Vazquez JA, Costello CE, Whitesides GM. Influence of the Zn(II) cofactor on the refolding of bovine carbonic anhydrase after denaturation with sodium dodecyl sulfate. Anal Chem. 2004 Dec 15; 76(24):7151-61.
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  104. Ivleva VB, Elkin YN, Budnik BA, Moyer SC, O'Connor PB, Costello CE. Coupling thin-layer chromatography with vibrational cooling matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for the analysis of ganglioside mixtures. Anal Chem. 2004 Nov 1; 76(21):6484-91.
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  105. Naggar EF, Costello CE, Zaia J. Competing fragmentation processes in tandem mass spectra of heparin-like glycosaminoglycans. J Am Soc Mass Spectrom. 2004 Nov; 15(11):1534-44.
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  106. Sethuraman M, McComb ME, Huang H, Huang S, Heibeck T, Costello CE, Cohen RA. Isotope-coded affinity tag (ICAT) approach to redox proteomics: identification and quantitation of oxidant-sensitive cysteine thiols in complex protein mixtures. J Proteome Res. 2004 Nov-Dec; 3(6):1228-33.
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  107. Pedrioli PG, Eng JK, Hubley R, Vogelzang M, Deutsch EW, Raught B, Pratt B, Nilsson E, Angeletti RH, Apweiler R, Cheung K, Costello CE, Hermjakob H, Huang S, Julian RK, Kapp E, McComb ME, Oliver SG, Omenn G, Paton NW, Simpson R, Smith R, Taylor CF, Zhu W, Aebersold R. A common open representation of mass spectrometry data and its application to proteomics research. Nat Biotechnol. 2004 Nov; 22(11):1459-66.
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  108. Cipollo JF, Awad AM, Costello CE, Hirschberg CB. srf-3, a mutant of Caenorhabditis elegans, resistant to bacterial infection and to biofilm binding, is deficient in glycoconjugates. J Biol Chem. 2004 Dec 17; 279(51):52893-903.
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  109. Singh BN, Lucas JJ, Hayes GR, Kumar I, Beach DH, Frajblat M, Gilbert RO, Sommer U, Costello CE. Tritrichomonas foetus induces apoptotic cell death in bovine vaginal epithelial cells. Infect Immun. 2004 Jul; 72(7):4151-8.
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  110. Cipollo JF, Awad A, Costello CE, Robbins PW, Hirschberg CB. Biosynthesis in vitro of Caenorhabditis elegans phosphorylcholine oligosaccharides. Proc Natl Acad Sci U S A. 2004 Mar 9; 101(10):3404-8.
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  111. Moody DB, Young DC, Cheng TY, Rosat JP, Roura-Mir C, O'Connor PB, Zajonc DM, Walz A, Miller MJ, Levery SB, Wilson IA, Costello CE, Brenner MB. T cell activation by lipopeptide antigens. Science. 2004 Jan 23; 303(5657):527-31.
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  112. Sethuraman M, McComb ME, Heibeck T, Costello CE, Cohen RA. Isotope-coded affinity tag approach to identify and quantify oxidant-sensitive protein thiols. Mol Cell Proteomics. 2004 Mar; 3(3):273-8.
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  113. O'Connor PB, Budnik BA, Ivleva VB, Kaur P, Moyer SC, Pittman JL, Costello CE. A high pressure matrix-assisted laser desorption ion source for Fourier transform mass spectrometry designed to accommodate large targets with diverse surfaces. J Am Soc Mass Spectrom. 2004 Jan; 15(1):128-32.
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  114. Ciucanu I, Costello CE. Elimination of oxidative degradation during the per-O-methylation of carbohydrates. J Am Chem Soc. 2003 Dec 31; 125(52):16213-9.
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  115. Moyer SC, Budnik BA, Pittman JL, Costello CE, O'Connor PB. Attomole peptide analysis by high-pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry. Anal Chem. 2003 Dec 1; 75(23):6449-54.
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  116. Zaia J, Li XQ, Chan SY, Costello CE. Tandem mass spectrometric strategies for determination of sulfation positions and uronic acid epimerization in chondroitin sulfate oligosaccharides. J Am Soc Mass Spectrom. 2003 Nov; 14(11):1270-81.
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  117. Yang J, Gitlin I, Krishnamurthy VM, Vazquez JA, Costello CE, Whitesides GM. Synthesis of monodisperse polymers from proteins. J Am Chem Soc. 2003 Oct 15; 125(41):12392-3.
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  118. Lim A, Sengupta S, McComb ME, Théberge R, Wilson WG, Costello CE, Jacobsen DW. In vitro and in vivo interactions of homocysteine with human plasma transthyretin. J Biol Chem. 2003 Dec 12; 278(50):49707-13.
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  119. Rauch J, Gumperz J, Robinson C, Sköld M, Roy C, Young DC, Lafleur M, Moody DB, Brenner MB, Costello CE, Behar SM. Structural features of the acyl chain determine self-phospholipid antigen recognition by a CD1d-restricted invariant NKT (iNKT) cell. J Biol Chem. 2003 Nov 28; 278(48):47508-15.
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  120. Connors LH, Lim A, Prokaeva T, Roskens VA, Costello CE. Tabulation of human transthyretin (TTR) variants, 2003. Amyloid. 2003 Sep; 10(3):160-84.
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  121. Lim A, Prokaeva T, McComb ME, Connors LH, Skinner M, Costello CE. Identification of S-sulfonation and S-thiolation of a novel transthyretin Phe33Cys variant from a patient diagnosed with familial transthyretin amyloidosis. Protein Sci. 2003 Aug; 12(8):1775-85.
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  122. Leymarie N, Costello CE, O'Connor PB. Electron capture dissociation initiates a free radical reaction cascade. J Am Chem Soc. 2003 Jul 23; 125(29):8949-58.
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  123. Hammarström P, Sekijima Y, White JT, Wiseman RL, Lim A, Costello CE, Altland K, Garzuly F, Budka H, Kelly JW. D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis? Biochemistry. 2003 Jun 10; 42(22):6656-63.
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  124. Zaia J, Costello CE. Tandem mass spectrometry of sulfated heparin-like glycosaminoglycan oligosaccharides. Anal Chem. 2003 May 15; 75(10):2445-55.
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  125. Kopp DA, Berg EA, Costello CE, Lippard SJ. Structural features of covalently cross-linked hydroxylase and reductase proteins of soluble methane monooxygenase as revealed by mass spectrometric analysis. J Biol Chem. 2003 Jun 6; 278(23):20939-45.
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  126. O'Connor PB, Costello CE, Earle WE. A high voltage RF oscillator for driving multipole ion guides. J Am Soc Mass Spectrom. 2002 Dec; 13(12):1370-5.
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  127. Yao Y, Berg EA, Costello CE, Troxler RF, Oppenheim FG. Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches. J Biol Chem. 2003 Feb 14; 278(7):5300-8.
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  128. Cipollo JF, Costello CE, Hirschberg CB. The fine structure of Caenorhabditis elegans N-glycans. J Biol Chem. 2002 Dec 20; 277(51):49143-57.
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  129. Inouye H, Bond JE, Deverin SP, Lim A, Costello CE, Kirschner DA. Molecular organization of amyloid protofilament-like assembly of betabellin 15D: helical array of beta-sandwiches. Biophys J. 2002 Sep; 83(3):1716-27.
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  130. Leymarie N, Berg EA, McComb ME, O'Connor PB, Grogan J, Oppenheim FG, Costello CE. Tandem mass spectrometry for structural characterization of proline-rich proteins: application to salivary PRP-3. Anal Chem. 2002 Aug 15; 74(16):4124-32.
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  131. McClellan JE, Costello CE, O'Connor PB, Zaia J. Influence of charge state on product ion mass spectra and the determination of 4S/6S sulfation sequence of chondroitin sulfate oligosaccharides. Anal Chem. 2002 Aug 1; 74(15):3760-71.
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  132. Gurcha SS, Baulard AR, Kremer L, Locht C, Moody DB, Muhlecker W, Costello CE, Crick DC, Brennan PJ, Besra GS. Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. Biochem J. 2002 Jul 15; 365(Pt 2):441-50.
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  133. Hopkins CE, O'Connor PB, Allen KN, Costello CE, Tolan DR. Chemical-modification rescue assessed by mass spectrometry demonstrates that gamma-thia-lysine yields the same activity as lysine in aldolase. Protein Sci. 2002 Jul; 11(7):1591-9.
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  134. Lim A, Prokaeva T, Connor LH, Falk RH, Skinner M, Costello CE. Identification of a novel transthyretin Thr59Lys/Arg104His. A case of compound heterozygosity in a Chinese patient diagnosed with familial transthyretin amyloidosis. Amyloid. 2002 Jun; 9(2):134-40.
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  135. Mirgorodskaya E, O'Connor PB, Costello CE. A general method for precalculation of parameters for sustained off resonance irradiation/collision-induced dissociation. J Am Soc Mass Spectrom. 2002 Apr; 13(4):318-24.
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  136. O'Connor PB, Mirgorodskaya E, Costello CE. High pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for minimization of ganglioside fragmentation. J Am Soc Mass Spectrom. 2002 Apr; 13(4):402-7.
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  137. Lim A, Prokaeva T, McComb ME, O'Connor PB, Théberge R, Connors LH, Skinner M, Costello CE. Characterization of transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping and DNA sequence analysis. Anal Chem. 2002 Feb 15; 74(4):741-51.
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  138. Zaia J, McClellan JE, Costello CE. Tandem mass spectrometric determination of the 4S/6S sulfation sequence in chondroitin sulfate oligosaccharides. Anal Chem. 2001 Dec 15; 73(24):6030-9.
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  139. Håkansson K, Cooper HJ, Emmett MR, Costello CE, Marshall AG, Nilsson CL. Electron capture dissociation and infrared multiphoton dissociation MS/MS of an N-glycosylated tryptic peptic to yield complementary sequence information. Anal Chem. 2001 Sep 15; 73(18):4530-6.
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  140. Lim A, Wally J, Walsh MT, Skinner M, Costello CE. Identification and location of a cysteinyl posttranslational modification in an amyloidogenic kappa1 light chain protein by electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry. Anal Biochem. 2001 Aug 1; 295(1):45-56.
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  141. Yao Y, Grogan J, Zehnder M, Lendenmann U, Nam B, Wu Z, Costello CE, Oppenheim FG. Compositional analysis of human acquired enamel pellicle by mass spectrometry. Arch Oral Biol. 2001 Apr; 46(4):293-303.
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  142. Upchurch GR, Goodman DG, Willoughby SR, Zhang YY, Welch GN, Freedman JE, Ye S, Costello CE, Loscalzo J. Heparin reacts with and inactivates nitric oxide. J Cardiovasc Pharmacol Ther. 2001 Apr; 6(2):163-73.
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  143. Costello CE, Beach DH, Singh BN. Acidic glycerol lipids of Trichomonas vaginalis and Tritrichomonas foetus. Biol Chem. 2001 Feb; 382(2):275-82.
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  144. Zaia J, Costello CE. Compositional analysis of glycosaminoglycans by electrospray mass spectrometry. Anal Chem. 2001 Jan 15; 73(2):233-9.
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  145. Mauro M, Kim J, Costello C, Laurence J. Role of transforming growth factor beta1 in microvascular endothelial cell apoptosis associated with thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome. Am J Hematol. 2001 Jan; 66(1):12-22.
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  146. O'Connor PB, Costello CE. A high pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry ion source for thermal stabilization of labile biomolecules. Rapid Commun Mass Spectrom. 2001; 15(19):1862-8.
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  147. O'Connor PB, Costello CE. Internal calibration on adjacent samples (InCAS) with Fourier transform mass spectrometry. Anal Chem. 2000 Dec 15; 72(24):5881-5.
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  148. Li H, Macdonald DM, Hronowski X, Costello CE, Leeman SE, Boyd ND. Further definition of the substance P (SP)/neurokinin-1 receptor complex. MET-174 is the site of photoinsertion p-benzoylphenylalanine4 SP. J Biol Chem. 2001 Apr 6; 276(14):10589-93.
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  149. Naik RS, Branch OH, Woods AS, Vijaykumar M, Perkins DJ, Nahlen BL, Lal AA, Cotter RJ, Costello CE, Ockenhouse CF, Davidson EA, Gowda DC. Glycosylphosphatidylinositol anchors of Plasmodium falciparum: molecular characterization and naturally elicited antibody response that may provide immunity to malaria pathogenesis. J Exp Med. 2000 Dec 4; 192(11):1563-76.
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  150. O'Connor PB, Costello CE. Application of multishot acquisition in Fourier transform mass spectrometry. Anal Chem. 2000 Oct 15; 72(20):5125-30.
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  151. Lim A, Makhov AM, Bond J, Inouye H, Connors LH, Griffith JD, Erickson BW, Kirschner DA, Costello CE. Betabellins 15D and 16D, de Novo designed beta-sandwich proteins that have amyloidogenic properties. J Struct Biol. 2000 Jun; 130(2-3):363-70.
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  152. Moody DB, Ulrichs T, Mühlecker W, Young DC, Gurcha SS, Grant E, Rosat JP, Brenner MB, Costello CE, Besra GS, Porcelli SA. CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection. Nature. 2000 Apr 20; 404(6780):884-8.
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  153. Connors LH, Richardson AM, Théberge R, Costello CE. Tabulation of transthyretin (TTR) variants as of 1/1/2000. Amyloid. 2000 Mar; 7(1):54-69.
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  154. Théberge R, Connors LH, Skinner M, Costello CE. Detection of transthyretin variants using immunoprecipitation and matrix-assisted laser desorption/ionization bioreactive probes: a clinical application of mass spectrometry. J Am Soc Mass Spectrom. 2000 Feb; 11(2):172-5.
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  155. Tang J, Rivers C, Karita E, Costello C, Allen S, Fultz PN, Schoenbaum EE, Kaslow RA. Allelic variants of human beta-chemokine receptor 5 (CCR5) promoter: evolutionary relationships and predictable associations with HIV-1 disease progression. Genes Immun. 1999 Sep; 1(1):20-7.
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  156. Connors LH, Théberge R, Skare J, Costello CE, Falk RH, Skinner M. A new transthyretin variant (Ser23Asn) associated with familial amyloidosis in a Portuguese patient. Amyloid. 1999 Jun; 6(2):114-8.
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  157. Niemelä R, Natunen J, Penttilä L, Salminen H, Helin J, Maaheimo H, Costello CE, Renkonen O. Isolation and characterization of linear polylactosamines containing one and two site-specifically positioned Lewis x determinants: WGA agarose chromatography in fractionation of mixtures generated by random, partial enzymatic alpha3-fucosylation of pure polylactosamines. Glycobiology. 1999 May; 9(5):517-26.
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  158. Kuliopulos A, Covic L, Seeley SK, Sheridan PJ, Helin J, Costello CE. Plasmin desensitization of the PAR1 thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy. Biochemistry. 1999 Apr 6; 38(14):4572-85.
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  159. Viseux N, Costello CE, Domon B. Post-source decay mass spectrometry: optimized calibration procedure and structural characterization of permethylated oligosaccharides. J Mass Spectrom. 1999 Apr; 34(4):364-76.
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  160. Perreault H, Costello CE. Stereochemical effects on the mass spectrometric behavior of native and derivatized trisaccharide isomers: comparisons with results from molecular modeling. J Mass Spectrom. 1999 Mar; 34(3):184-97.
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  161. Théberge R, Connors L, Skare J, Skinner M, Falk RH, Costello CE. A new amyloidogenic transthyretin variant (Val122Ala) found in a compound heterozygous patient. Amyloid. 1999 Mar; 6(1):54-8.
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  162. Costello CE. Bioanalytic applications of mass spectrometry. Curr Opin Biotechnol. 1999 Feb; 10(1):22-8.
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  163. Théberge R, Connors L, Skinner M, Skare J, Costello CE. Characterization of transthyretin mutants from serum using immunoprecipitation, HPLC/electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry. Anal Chem. 1999 Jan 15; 71(2):452-9.
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  164. Guittard J, Hronowski XL, Costello CE. Direct matrix-assisted laser desorption/ionization mass spectrometric analysis of glycosphingolipids on thin layer chromatographic plates and transfer membranes. Rapid Commun Mass Spectrom. 1999; 13(18):1838-49.
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  165. Solouki T, Reinhold BB, Costello CE, O'Malley M, Guan S, Marshall AG. Electrospray ionization and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry of permethylated oligosaccharides. Anal Chem. 1998 Mar 1; 70(5):857-64.
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  166. Russell KJ, McRedmond J, Mukherji N, Costello C, Keatings V, Linnane S, Henry M, Fitzgerald MX, O'Connor CM. Neutrophil adhesion molecule surface expression and responsiveness in cystic fibrosis. Am J Respir Crit Care Med. 1998 Mar; 157(3 Pt 1):756-61.
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  167. Salminen H, Ahokas K, Niemelä R, Penttilä L, Maaheimo H, Helin J, Costello CE, Renkonen O. Improved enzymatic synthesis of a highly potent oligosaccharide antagonist of L-selectin. FEBS Lett. 1997 Dec 15; 419(2-3):220-6.
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  168. Costello CE. Time, life ... and mass spectrometry. New techniques to address biological questions. Biophys Chem. 1997 Oct; 68(1-3):173-88.
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  169. Jiménez CR, Li KW, Dreisewerd K, Mansvelder HD, Brussaard AB, Reinhold BB, Van der Schors RC, Karas M, Hillenkamp F, Burbach JP, Costello CE, Geraerts WP. Pattern changes of pituitary peptides in rat after salt-loading as detected by means of direct, semiquantitative mass spectrometric profiling. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9481-6.
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  170. Helin J, Penttilä L, Leppänen A, Maaheimo H, Lauri S, Costello CE, Renkonen O. The beta 1,6-GlcNAc transferase activity present in hog gastric mucosal microsomes catalyses site-specific branch formation on a long polylactosamine backbone. FEBS Lett. 1997 Aug 4; 412(3):637-42.
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  171. Natunen J, Seppo A, Helin J, Reinhold BB, Rabina J, Costello CE, Renkonen O. Enzymatic transfer of a beta1,6-linked N-acetylglucosamine to the alpha-galactose of globo-N-tetraose: in vitro synthesis of a novel hybrid pentasaccharide of lacto-globo type. Glycobiology. 1997 Jul; 7(5):711-8.
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  172. Leppanen A, Salminen H, Zhu Y, Maaheimo H, Helin J, Costello CE, Renkonen O. In vitro biosynthesis of a decasaccharide prototype of multiply branched polylactosaminoglycan backbones. Biochemistry. 1997 Jun 10; 36(23):7026-36.
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  173. Renkonen O, Toppila S, Penttilä L, Salminen H, Helin J, Maaheimo H, Costello CE, Turunen JP, Renkonen R. Synthesis of a new nanomolar saccharide inhibitor of lymphocyte adhesion: different polylactosamine backbones present multiple sialyl Lewis x determinants to L-selectin in high-affinity mode. Glycobiology. 1997 Jun; 7(4):453-61.
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  174. Popham DL, Helin J, Costello CE, Setlow P. Muramic lactam in peptidoglycan of Bacillus subtilis spores is required for spore outgrowth but not for spore dehydration or heat resistance. Proc Natl Acad Sci U S A. 1996 Dec 24; 93(26):15405-10.
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  175. Popham DL, Helin J, Costello CE, Setlow P. Analysis of the peptidoglycan structure of Bacillus subtilis endospores. J Bacteriol. 1996 Nov; 178(22):6451-8.
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  176. Kage R, Leeman SE, Krause JE, Costello CE, Boyd ND. Identification of methionine as the site of covalent attachment of a p-benzoyl-phenylalanine-containing analogue of substance P on the substance P (NK-1) receptor. J Biol Chem. 1996 Oct 18; 271(42):25797-800.
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  177. Ekman R, Juhasz P, Heilig M, Agren H, Costello CE. Novel neuropeptide Y processing in human cerebrospinal fluid from depressed patients. Peptides. 1996; 17(7):1107-11.
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  178. Costello CE. Application of tandem mass spectral approaches to structural determinations of saponins. Adv Exp Med Biol. 1996; 405:317-30.
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  179. Niemelä R, Räbinä J, Leppänen A, Maaheimo H, Costello CE, Renkonen O. Site-directed enzymatic alpha-(1-->3)-L-fucosylation of the tetrasaccharide Gal beta(1-->4)GlcNAc beta(1-->3)Gal beta(1-->4)GlcNAc at the distal N-acetyllactosamine unit. Carbohydr Res. 1995 Dec 27; 279:331-8.
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  180. Niemelä R, Penttilä L, Seppo A, Helin J, Leppänen A, Räbinä J, Uusitalo L, Maaheimo H, Taskinen J, Costello CE, et al. Enzyme-assisted synthesis of a bivalent high-affinity dodecasaccharide inhibitor of mouse gamete adhesion. The length of the chains carrying distal alpha 1,3-bonded galactose residues is critical. FEBS Lett. 1995 Jun 19; 367(1):67-72.
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  181. Reinhold VN, Reinhold BB, Costello CE. Carbohydrate molecular weight profiling, sequence, linkage, and branching data: ES-MS and CID. Anal Chem. 1995 Jun 1; 67(11):1772-84.
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  182. Hayes GR, Williams A, Costello CE, Enns CA, Lucas JJ. The critical glycosylation site of human transferrin receptor contains a high-mannose oligosaccharide. Glycobiology. 1995 Mar; 5(2):227-32.
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  183. Singh BN, Lucas JJ, Beach DH, Costello CE. Expression of a novel cell surface lipophosphoglycan-like glycoconjugate in Trypanosoma cruzi epimastigotes. J Biol Chem. 1994 Sep 2; 269(35):21972-82.
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  184. Barbarics E, Kronauge JF, Costello CE, Jànoki GA, Holman BL, Davison A, Jones AG. In vivo metabolism of the technetium isonitrile complex [Tc(2-ethoxy-2-methyl-1-isocyanopropane)6]+. Nucl Med Biol. 1994 May; 21(4):583-91.
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  185. Singh BN, Beach DH, Lindmark DG, Costello CE. Identification of the lipid moiety and further characterization of the novel lipophosphoglycan-like glycoconjugates of Trichomonas vaginalis and Trichomonas foetus. Arch Biochem Biophys. 1994 Mar; 309(2):273-80.
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  186. Costello CE, Juhasz P, Perreault H. New mass spectral approaches to ganglioside structure determinations. Prog Brain Res. 1994; 101:45-61.
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  187. Snook ME, Blum MS, Whitman DW, Arrendale RF, Costello CE, Harwood JS. Caffeoyltartronic acid from catnip (Nepeta cataria): A precursor for catechol in lubber grasshopper (Romalea guttata) defensive secretions. J Chem Ecol. 1993 Sep; 19(9):1957-66.
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  188. Treuheit MJ, Costello CE, Kirley TL. Structures of the complex glycans found on the beta-subunit of (Na,K)-ATPase. J Biol Chem. 1993 Jul 5; 268(19):13914-9.
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  189. Costello CE, Glushka J, van Halbeek H, Singh BN. Structural characterization of novel inositol phosphosphingolipids of Tritrichomonas foetus and Trichomonas vaginalis. Glycobiology. 1993 Jun; 3(3):261-9.
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  190. Juhasz P, Costello CE, Biemann K. Matrix-assisted laser desorption ionization mass spectrometry with 2-(4-hydroxyphenylazo)benzoic acid matrix. J Am Soc Mass Spectrom. 1993 May; 4(5):399-409.
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  191. Juhasz P, Costello CE. Generation of large radical ions from oligometallocenes by matrix-assisted laser desorption ionization. Rapid Commun Mass Spectrom. 1993 May; 7(5):343-51.
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  192. Costello CE. Tandem mass spectrometry. Methods Mol Biol. 1993; 17:285-313.
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  193. Juhasz P, Costello CE. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry of underivatized and permethylated gangliosides. J Am Soc Mass Spectrom. 1992 Nov; 3(8):785-96.
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  194. Gage DA, Rathke E, Costello CE, Jones MZ. Determination of sequence and linkage of tissue oligosaccharides in caprine beta-mannosidosis by fast atom bombardment, collisionally activated dissociation tandem mass spectrometry. Glycoconj J. 1992 Jun; 9(3):126-31.
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  195. Treuheit MJ, Costello CE, Halsall HB. Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein. Biochem J. 1992 Apr 1; 283 ( Pt 1):105-12.
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  196. Jones MZ, Rathke EJ, Gage DA, Costello CE, Murakami K, Ohta M, Matsuura F. Oligosaccharides accumulated in the bovine beta-mannosidosis kidney. J Inherit Metab Dis. 1992; 15(1):57-67.
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  197. Singh BN, Costello CE, Beach DH. Structures of glycophosphosphingolipids of Tritrichomonas foetus: a novel glycophosphosphingolipid. Arch Biochem Biophys. 1991 May 1; 286(2):409-18.
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  198. Singh BN, Costello CE, Beach DH, Holz GG. Characterization of glycosyl phosphatidylinositol lipids of parasitic protozoans: Leishmania mexicana mexicana promastigotes, Trypanosoma cruzi Peru epimastigotes and Tritrichomonas foetus. Indian J Biochem Biophys. 1990 Dec; 27(6):411-5.
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  199. Ilyas AA, Chou DK, Jungalwala FB, Costello C, Quarles RH. Variability in the structural requirements for binding of human monoclonal anti-myelin-associated glycoprotein immunoglobulin M antibodies and HNK-1 to sphingoglycolipid antigens. J Neurochem. 1990 Aug; 55(2):594-601.
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  200. Lhomme O, Bruneteau M, Costello CE, Mas P, Molot PM, Dell A, Tiller PR, Michel G. Structural investigations and biological activity of inositol sphingophospholipids from Phytophthora capsici. Eur J Biochem. 1990 Jul 20; 191(1):203-9.
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  201. Comess KM, Costello CE, Lippard SJ. Identification and characterization of a novel linkage isomerization in the reaction of trans-diamminedichloroplatinum(II) with 5'-d(TCTACGCGTTCT). Biochemistry. 1990 Feb 27; 29(8):2102-10.
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  202. Lepre CA, Chassot L, Costello CE, Lippard SJ. Synthesis and characterization of trans-[Pt(NH3)2Cl2] adducts of d(CCTCGAGTCTCC).d(GGAGACTCGAGG). Biochemistry. 1990 Jan 23; 29(3):811-23.
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  203. Costello CE, Vath JE. Tandem mass spectrometry of glycolipids. Methods Enzymol. 1990; 193:738-68.
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  204. Domon B, Vath JE, Costello CE. Analysis of derivatized ceramides and neutral glycosphingolipids by high-performance tandem mass spectrometry. Anal Biochem. 1990 Jan; 184(1):151-64.
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  205. Dever TE, Costello CE, Owens CL, Rosenberry TL, Merrick WC. Location of seven post-translational modifications in rabbit elongation factor 1 alpha including dimethyllysine, trimethyllysine, and glycerylphosphorylethanolamine. J Biol Chem. 1989 Dec 5; 264(34):20518-25.
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  206. Chou DK, Dodd J, Jessell TM, Costello CE, Jungalwala FB. Identification of alpha-galactose (alpha-fucose)-asialo-GM1 glycolipid expressed by subsets of rat dorsal root ganglion neurons. J Biol Chem. 1989 Feb 25; 264(6):3409-15.
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  207. Singh BN, Costello CE, Beach DH, Holz GG. Di-O-alkylglycerol, mono-O-alkylglycerol and ceramide inositol phosphates of Leishmania mexicana mexicana promastigotes. Biochem Biophys Res Commun. 1988 Dec 30; 157(3):1239-46.
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  208. Chin DH, Zeng CH, Costello CE, Goldberg IH. Sites in the diyne-ene bicyclic core of neocarzinostatin chromophore responsible for hydrogen abstraction from DNA. Biochemistry. 1988 Oct 18; 27(21):8106-14.
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  209. Offner GD, Brecher P, Sawlivich WB, Costello CE, Troxler RF. Characterization and amino acid sequence of a fatty acid-binding protein from human heart. Biochem J. 1988 May 15; 252(1):191-8.
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  210. Domon B, Costello CE. Structure elucidation of glycosphingolipids and gangliosides using high-performance tandem mass spectrometry. Biochemistry. 1988 Mar 8; 27(5):1534-43.
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  211. Singh BN, Costello CE, Levery SB, Walenga RW, Beach DH, Mueller JF, Holz GG. Tegument galactosylceramides of the cestode Spirometra mansonoides. Mol Biochem Parasitol. 1987 Nov; 26(1-2):99-111.
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  212. Sato K, Asada T, Ishihara M, Kunihiro F, Kammei Y, Kubota E, Costello CE, Martin SA, Scoble HA, Biemann K. High-performance tandem mass spectrometry: calibration and performance of linked scans of a four-sector instrument. Anal Chem. 1987 Jul 1; 59(13):1652-9.
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  213. Furlong ST, Leary JA, Costello CE, Dawidowicz EA. Isolation and identification of 1(3),2-diacylglyceryl-(3)-O-4'-(N,N,N-trimethyl)homoserine from the soil amoeba, Acanthamoeba castellanii. J Lipid Res. 1986 Nov; 27(11):1182-9.
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  214. Chou DK, Ilyas AA, Evans JE, Costello C, Quarles RH, Jungalwala FB. Structure of sulfated glucuronyl glycolipids in the nervous system reacting with HNK-1 antibody and some IgM paraproteins in neuropathy. J Biol Chem. 1986 Sep 5; 261(25):11717-25.
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  215. Gabel CA, Costello CE, Reinhold VN, Kurz L, Kornfeld S. Identification of methylphosphomannosyl residues as components of the high mannose oligosaccharides of Dictyostelium discoideum glycoproteins. J Biol Chem. 1984 Nov 25; 259(22):13762-9.
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  216. Young JD, Costello CE, Van Langenhove A, Haber E, Matsueda GR. Synthesis of a cyclic fibrin-like peptide and its analysis by fast atom bombardment mass spectrometry. Int J Pept Protein Res. 1983 Sep; 22(3):374-80.
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  217. Costello CE, Brodack JW, Jones AG, Davison A, Johnson DL, Kasina S, Fritzberg AR. The investigation of radiopharmaceutical components by fast atom bombardment mass spectrometry: the identification of Tc-HIDA and the epimers of Tc-CO2DADS. J Nucl Med. 1983 Apr; 24(4):353-5.
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  218. Catovesky D, Costello C, Loukopoulos D, Fessas PR, Foxley JM, Traub NE, Mills MJ, O'Brien M. Hairy cell leukemia and myelomatosis: chance association or clinical manifestations of the same B-cell disease spectrum. Blood. 1981 Apr; 57(4):758-63.
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  219. Van Langenhove A, Costello CE, Biller JE, Biemann K, Browne TR. A mass spectrometric method for the determination of stable isotope labeled phenytoin suitable for pulse dosing studies. Biomed Mass Spectrom. 1980 Nov; 7(11-12):576-81.
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  220. Gupta CM, Costello CE, Khorana HG. Sites of intermolecular crosslinking of fatty acyl chains in phospholipids carrying a photoactivable carbene precursor. Proc Natl Acad Sci U S A. 1979 Jul; 76(7):3139-43.
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  221. Iwamori M, Costello C, Moser HW. Analysis and quantitation of free ceramide containing nonhydroxy and 2-hydroxy fatty acids, and phytosphingosine by high-performance liquid chromatography. J Lipid Res. 1979 Jan; 20(1):86-96.
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  222. Shoyama Y, Okabe H, Kishimoto Y, Costello C. Total synthesis of stereospecific sphingosine and ceramide. J Lipid Res. 1978 Feb; 19(2):250-9.
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