Phillips Wesley Robbins, PhD
Emeritus Professor
Boston University Henry M. Goldman School of Dental Medicine
Dept of Molecular & Cell Biology

PhD, University of Illinois




Phillips Wesley Robbins is a Professor Emeritus in the Department of Molecular and Cell Biology at the Boston University School of Dental Medicine. He moved to BU in 1998 following a career of almost 40 years on the faculty at the Massachusetts Institute of Technology. Robbins was born in 1930 in Barre, Massachusetts and attended high school in West Springfield, Massachusetts. He later described a high school physics course as an inspiration for his plans for a science career, though he continued to consider following the family tradition by becoming a medical missionary. He settled on biochemistry as his chosen field as an undergraduate at DePauw University, from which he graduated in 1952. He received his Ph.D. in 1955 from the University of Indiana under the supervision of Herbert E. Carter and then became a postdoctoral fellow with Fritz Lipmann, first at Massachusetts General Hospital and then moving with the group to Rockefeller University.

Robbins joined the faculty at the Massachusetts Institute of Technology in 1960 as one of several young biochemists hired by Jack Buchanan into the Department of Biology. There he worked particularly closely with Salvador Luria, studying the structure and biochemistry of lipopolysaccharides.

In 1998, after nearly 40 years at MIT, Robbins moved to the Boston University School of Dental Medicine, where he has worked in collaboration with John Samuelson and with two of his own former postdoctoral fellows, department head Carlos Hirschberg and associate dean Maria Kukuruzinska.

Robbins received the Eli Lilly Award in Biological Chemistry in 1966, was elected to the National Academy of Sciences in 1982 and received the Karl Meyer Award for Lifetime Achievement in Glycobiology in 2000.

Robbins' research has focused on a variety of biochemical pathways. In his early career at MIT, he worked closely with Luria studying the structure and biosynthesis of lipopolysaccharides, including elucidating the structure of bactoprenol and identifying the direction of chain elongation in LPS synthesis in bacteria. He later moved on to studying the biochemistry of the eukaryotic N-linked glycosylation pathway and more recently, with John Samuelson, has studied the evolution of this pathway in protists. He has also worked on the problem of chitin synthesis and its role in yeast.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Novel Broad Spectrum Therapeutic Glycans against Category B Pathogens
09/01/2010 - 08/31/2012 (Subcontract PI)
Trustees of Boston College NIH NIAID
7U01AI075563-04

Three Lectin Model of Amebic Encystation and Excystation
01/01/2000 - 12/31/2002 (PI)
Harvard University NIH NIAID

Expression and Characterization of a Fourth Chitinase from the Fungal Pathogen Candida albicans
06/01/2000 - 05/31/2001 (Dept Sponsor)
American Association for Dental Research (AADR)



Title


Yr Title Project-Sub Proj Pubs
2019 Biosecurity Core 5UC7AI095321-06-8666 1
2018 Biosecurity Core 5UC7AI095321-05-8666 1
2017 Biosecurity Core 5UC7AI095321-04-8666 1
2016 Biosecurity Core 2UC7AI095321-03-8666 1
2010 ROBBINS Glycosylation and Glycosidases-Cell and Molecular Biology 5R01GM031318-47 100
2009 ROBBINS Glycosylation and Glycosidases-Cell and Molecular Biology 5R01GM031318-46 100
2008 ANALYSIS OF FISSION YEAST CELL WALL 5P41RR010888-12-5229 259
2008 EVOLUTION AND DIVERSITY OF EUKARYOTIC GLYCOSYLATION 5P41RR010888-12-5253 259
2008 ROBBINS Glycosylation and Glycosidases-Cell and Molecular Biology 2R01GM031318-45A1 100
2007 ANALYSIS OF FISSION YEAST CELL WALL 2P41RR010888-11-8050 259
Showing 10 of 42 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Bandini G, Haserick JR, Motari E, Ouologuem DT, Lourido S, Roos DS, Costello CE, Robbins PW, Samuelson J. O-fucosylated glycoproteins form assemblies in close proximity to the nuclear pore complexes of Toxoplasma gondii. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11567-11572.View Related Profiles. PMID: 27663739
     
  2. Chatterjee A, Ratner DM, Ryan CM, Johnson PJ, O'Keefe BR, Secor WE, Anderson DJ, Robbins PW, Samuelson J. Anti-Retroviral Lectins Have Modest Effects on Adherence of Trichomonas vaginalis to Epithelial Cells In Vitro and on Recovery of Tritrichomonas foetus in a Mouse Vaginal Model. PLoS One. 2015; 10(8):e0135340.View Related Profiles. PMID: 26252012; PMCID: PMC4529277; DOI: 10.1371/journal.pone.0135340;
     
  3. Xu YX, Ashline D, Liu L, Tassa C, Shaw SY, Ravid K, Layne MD, Reinhold V, Robbins PW. The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis. J Lipid Res. 2015 Feb; 56(2):266-76.View Related Profiles. PMID: 25528754; PMCID: PMC4306681; DOI: 10.1194/jlr.M053017;
     
  4. Samuelson J, Robbins PW. Effects of N-glycan precursor length diversity on quality control of protein folding and on protein glycosylation. Semin Cell Dev Biol. 2015 May; 41:121-8.View Related Profiles. PMID: 25475176; PMCID: PMC4452448; DOI: 10.1016/j.semcdb.2014.11.008;
     
  5. Samuelson J, Bushkin GG, Chatterjee A, Robbins PW. Strategies to discover the structural components of cyst and oocyst walls. Eukaryot Cell. 2013 Dec; 12(12):1578-87.View Related Profiles. PMID: 24096907; PMCID: PMC3889564; DOI: 10.1128/EC.00213-13;
     
  6. Bushkin GG, Motari E, Carpentieri A, Dubey JP, Costello CE, Robbins PW, Samuelson J. Evidence for a structural role for acid-fast lipids in oocyst walls of Cryptosporidium, Toxoplasma, and Eimeria. MBio. 2013; 4(5):e00387-13.View Related Profiles. PMID: 24003177; PMCID: PMC3760245; DOI: 10.1128/mBio.00387-13;
     
  7. Bushkin GG, Motari E, Magnelli P, Gubbels MJ, Dubey JP, Miska KB, Bullitt E, Costello CE, Robbins PW, Samuelson J. ß-1,3-glucan, which can be targeted by drugs, forms a trabecular scaffold in the oocyst walls of Toxoplasma and Eimeria. MBio. 2012; 3(5).View Related Profiles. PMID: 23015739; PMCID: PMC3518913; DOI: 10.1128/mBio.00258-12;
     
  8. Samuelson J, Robbins P. A simple fibril and lectin model for cyst walls of Entamoeba and perhaps Giardia. Trends Parasitol. 2011 Jan; 27(1):17-22.View Related Profiles. PMID: 20934911; PMCID: PMC3014499; DOI: 10.1016/j.pt.2010.09.002;
     
  9. Robbins P. Stents, statins, and other dumb luck. J Biol Chem. 2011 Jan 21; 286(3):1669-74. PMID: 21098482; PMCID: PMC3023461; DOI: 10.1074/jbc.X110.205633;
     
  10. Carpentieri A, Ratner DM, Ghosh SK, Banerjee S, Bushkin GG, Cui J, Lubrano M, Steffen M, Costello CE, O'Keefe B, Robbins PW, Samuelson J. The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites. Eukaryot Cell. 2010 Nov; 9(11):1661-8.View Related Profiles. PMID: 20852023; PMCID: PMC2976296; DOI: 10.1128/EC.00166-10;
     
Showing 10 of 123 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 116 publications over 36 distinct years, with a maximum of 10 publications in 1996

YearPublications
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Contact for Mentoring:

72 E. Concord St Evans Building
Boston MA 02118
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