Esther S. Bullitt, PhD
|Institution||Boston University School of Medicine|
|Department||Physiology & Biophysics|
|Address||700 Albany St Ctr for Adv Biomed Res|
Boston MA 02118
|Title||Graduate Faculty (Primary Mentor of Grad Students)|
|Institution||Boston University School of Medicine, Graduate Medical Sciences|
Structural studies of biological macromolecular assemblies are providing an understanding of cellular function. In our laboratory, we utilize electron microscopy and image reconstruction to investigate questions about microbial virulence.
Work in the lab currently focuses on bacterial adhesion pili (fimbriae), type III secretion system needles, and virus replication. These projects address basic medical research questions directed at understanding bacterial adhesion to human host tissue and viral replication. Our data support development of novel therapeutics targeting these important health issues including, for example, development of a vaccine against traveler’s diarrhea.
- Image processing
- Macromolecular assemblies
- Structural biology
- electron cryomicroscopy (cryoEM)
- bacterial adhesion
- virus replication
- type III secretion system
- 3D helical reconstruction
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