Keywords
Last Name

Esther S. Bullitt, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics
Address700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Phone(617) 638-5037
ORCID ORCID Icon0000-0003-2447-6209
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Research Expertise & Professional Interests
Structural studies of biological macromolecular assemblies are providing an understanding of cellular function. In our laboratory, we utilize electron microscopy and image reconstruction to investigate questions about microbial virulence.

Work in the lab currently focuses on bacterial adhesion pili (fimbriae), type III secretion system needles, and virus replication. These projects address basic medical research questions directed at understanding bacterial adhesion to human host tissue and viral replication. Our data support development of novel therapeutics targeting these important health issues including, for example, development of a vaccine against traveler’s diarrhea.

 Self-Described Keywords
  • Image processing
  • Macromolecular assemblies
  • Structural biology
  • electron cryomicroscopy (cryoEM)
  • bacterial adhesion
  • virus replication
  • type III secretion system
  • 3D helical reconstruction
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Mortezaei N, Epler CR, Shao PP, Shirdel M, Singh B, McVeigh A, Uhlin BE, Savarino SJ, Andersson M, Bullitt E. Structure and function of enterotoxigenic Escherichia coli fimbriae from differing assembly pathways. Mol Microbiol. 2015 Jan; 95(1):116-26.
    View in: PubMed
  2. Mortezaei N, Singh B, Bullitt E, Uhlin BE, Andersson M. P-fimbriae in the presence of anti-PapA antibodies: new insight of antibodies action against pathogens. Sci Rep. 2013; 3:3393.
    View in: PubMed
  3. Wang J, Ptacek JB, Kirkegaard K, Bullitt E. Double-membraned liposomes sculpted by poliovirus 3AB protein. J Biol Chem. 2013 Sep 20; 288(38):27287-98.
    View in: PubMed
  4. Wang J, Lyle JM, Bullitt E. Surface for catalysis by poliovirus RNA-dependent RNA polymerase. J Mol Biol. 2013 Jul 24; 425(14):2529-40.
    View in: PubMed
  5. Bushkin GG, Motari E, Magnelli P, Gubbels MJ, Dubey JP, Miska KB, Bullitt E, Costello CE, Robbins PW, Samuelson J. ß-1,3-glucan, which can be targeted by drugs, forms a trabecular scaffold in the oocyst walls of Toxoplasma and Eimeria. MBio. 2012; 3(5).
    View in: PubMed
  6. Wang J, Bullitt E, Kirkegaard K. Surface for catalysis by poliovirus RNA dependent RNA polymerase. Microsc Microanal. 2012 Jul; 18 Suppl 2:68-9.
    View in: PubMed
  7. Epler CR, Dickenson NE, Bullitt E, Picking WL. Ultrastructural analysis of IpaD at the tip of the nascent MxiH type III secretion apparatus of Shigella flexneri. J Mol Biol. 2012 Jun 29; 420(1-2):29-39.
    View in: PubMed
  8. Andersson M, Björnham O, Svantesson M, Badahdah A, Uhlin BE, Bullitt E. A structural basis for sustained bacterial adhesion: biomechanical properties of CFA/I pili. J Mol Biol. 2012 Feb 3; 415(5):918-28.
    View in: PubMed
  9. Tellez AB, Wang J, Tanner EJ, Spagnolo JF, Kirkegaard K, Bullitt E. Interstitial contacts in an RNA-dependent RNA polymerase lattice. J Mol Biol. 2011 Sep 30; 412(4):737-50.
    View in: PubMed
  10. Aprikian P, Interlandi G, Kidd BA, Le Trong I, Tchesnokova V, Yakovenko O, Whitfield MJ, Bullitt E, Stenkamp RE, Thomas WE, Sokurenko EV. The bacterial fimbrial tip acts as a mechanical force sensor. PLoS Biol. 2011 May; 9(5):e1000617.
    View in: PubMed
  11. Chatterjee A, Carpentieri A, Ratner DM, Bullitt E, Costello CE, Robbins PW, Samuelson J. Giardia cyst wall protein 1 is a lectin that binds to curled fibrils of the GalNAc homopolymer. PLoS Pathog. 2010; 6(8):e1001059.
    View in: PubMed
  12. Spagnolo JF, Rossignol E, Bullitt E, Kirkegaard K. Enzymatic and nonenzymatic functions of viral RNA-dependent RNA polymerases within oligomeric arrays. RNA. 2010 Feb; 16(2):382-93.
    View in: PubMed
  13. Chatterjee A, Ghosh SK, Jang K, Bullitt E, Moore L, Robbins PW, Samuelson J. Evidence for a "wattle and daub" model of the cyst wall of entamoeba. PLoS Pathog. 2009 Jul; 5(7):e1000498.
    View in: PubMed
  14. Li YF, Poole S, Nishio K, Jang K, Rasulova F, McVeigh A, Savarino SJ, Xia D, Bullitt E. Structure of CFA/I fimbriae from enterotoxigenic Escherichia coli. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10793-8.
    View in: PubMed
  15. Kendall A, McDonald M, Bian W, Bowles T, Baumgarten SC, Shi J, Stewart PL, Bullitt E, Gore D, Irving TC, Havens WM, Ghabrial SA, Wall JS, Stubbs G. Structure of flexible filamentous plant viruses. J Virol. 2008 Oct; 82(19):9546-54.
    View in: PubMed
  16. Turcios-Ruiz RM, Axelrod P, St John K, Bullitt E, Donahue J, Robinson N, Friss HE. Outbreak of necrotizing enterocolitis caused by norovirus in a neonatal intensive care unit. J Pediatr. 2008 Sep; 153(3):339-44.
    View in: PubMed
  17. Mu XQ, Savarino SJ, Bullitt E. The three-dimensional structure of CFA/I adhesion pili: traveler's diarrhea bacteria hang on by a spring. J Mol Biol. 2008 Feb 22; 376(3):614-20.
    View in: PubMed
  18. Verger D, Bullitt E, Hultgren SJ, Waksman G. Crystal structure of the P pilus rod subunit PapA. PLoS Pathog. 2007 May 18; 3(5):e73.
    View in: PubMed
  19. Poole ST, McVeigh AL, Anantha RP, Lee LH, Akay YM, Pontzer EA, Scott DA, Bullitt E, Savarino SJ. Donor strand complementation governs intersubunit interaction of fimbriae of the alternate chaperone pathway. Mol Microbiol. 2007 Mar; 63(5):1372-84.
    View in: PubMed
  20. Jiang ZG, Gantz D, Bullitt E, McKnight CJ. Defining lipid-interacting domains in the N-terminal region of apolipoprotein B. Biochemistry. 2006 Oct 3; 45(39):11799-808.
    View in: PubMed
  21. Mu XQ, Bullitt E. Structure and assembly of P-pili: a protruding hinge region used for assembly of a bacterial adhesion filament. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):9861-6.
    View in: PubMed
  22. Mu XQ, Jiang ZG, Bullitt E. Localization of a critical interface for helical rod formation of bacterial adhesion P-pili. J Mol Biol. 2005 Feb 11; 346(1):13-20.
    View in: PubMed
  23. Frenkiel-Krispin D, Sack R, Englander J, Shimoni E, Eisenstein M, Bullitt E, Horowitz-Scherer R, Hayes CS, Setlow P, Minsky A, Wolf SG. Structure of the DNA-SspC complex: implications for DNA packaging, protection, and repair in bacterial spores. J Bacteriol. 2004 Jun; 186(11):3525-30.
    View in: PubMed
  24. Mu XQ, Egelman EH, Bullitt E. Structure and function of Hib pili from Haemophilus influenzae type b. J Bacteriol. 2002 Sep; 184(17):4868-74.
    View in: PubMed
  25. Lyle JM, Bullitt E, Bienz K, Kirkegaard K. Visualization and functional analysis of RNA-dependent RNA polymerase lattices. Science. 2002 Jun 21; 296(5576):2218-22.
    View in: PubMed
  26. Saulino ET, Bullitt E, Hultgren SJ. Snapshots of usher-mediated protein secretion and ordered pilus assembly. Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16):9240-5.
    View in: PubMed
  27. Cheng W, Bullitt E, Bhattacharyya L, Brewer CF, Makowski L. Electron microscopy and x-ray diffraction studies of Lotus tetragonolobus A isolectin cross-linked with a divalent Lewisx oligosaccharide, an oncofetal antigen. J Biol Chem. 1998 Dec 25; 273(52):35016-22.
    View in: PubMed
  28. Bullitt E, Makowski L. Bacterial adhesion pili are heterologous assemblies of similar subunits. Biophys J. 1998 Jan; 74(1):623-32.
    View in: PubMed
  29. Bullitt E, Rout MP, Kilmartin JV, Akey CW. The yeast spindle pole body is assembled around a central crystal of Spc42p. Cell. 1997 Jun 27; 89(7):1077-86.
    View in: PubMed
  30. Bullitt E, Jones CH, Striker R, Soto G, Jacob-Dubuisson F, Pinkner J, Wick MJ, Makowski L, Hultgren SJ. Development of pilus organelle subassemblies in vitro depends on chaperone uncapping of a beta zipper. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):12890-5.
    View in: PubMed
  31. St Geme JW, Pinkner JS, Krasan GP, Heuser J, Bullitt E, Smith AL, Hultgren SJ. Haemophilus influenzae pili are composite structures assembled via the HifB chaperone. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11913-8.
    View in: PubMed
  32. Bullitt E, Makowski L. Structural polymorphism of bacterial adhesion pili. Nature. 1995 Jan 12; 373(6510):164-7.
    View in: PubMed
  33. Specthrie L, Bullitt E, Horiuchi K, Model P, Russel M, Makowski L. Construction of a microphage variant of filamentous bacteriophage. J Mol Biol. 1992 Dec 5; 228(3):720-4.
    View in: PubMed
  34. Bullitt ES, DeRosier DJ, Coluccio LM, Tilney LG. Three-dimensional reconstruction of an actin bundle. J Cell Biol. 1988 Aug; 107(2):597-611.
    View in: PubMed
  35. Trachtenberg S, Stokes D, Bullitt E, DeRosier D. Actin and flagellar filaments: two helical structures with variable twist. Ann N Y Acad Sci. 1986; 483:88-99.
    View in: PubMed
  36. Weisel JW, Stauffacher CV, Bullitt E, Cohen C. A model for fibrinogen: domains and sequence. Science. 1985 Dec 20; 230(4732):1388-91.
    View in: PubMed
Esther's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
BU Co-Authors
_
Similar BU People
_
Same Department