C. James McKnight, PhD
|Institution||Boston University School of Medicine|
|Department||Physiology & Biophysics|
|Address||700 Albany St Ctr for Adv Biomed Res|
Boston MA 02118
|Title||Graduate Faculty (Primary Mentor of Grad Students)|
|Institution||Boston University School of Medicine, Graduate Medical Sciences|
My expertise is in protein structure, function, dynamics and folding and chemistry. Methods used include molecular biology, chromatography, NMR spectroscopy, X-ray crystallography, UV/Vis and circular dichroism spectroscopy, electron microscopy, molecular modeling and dynamics. We look at actin binding proteins (especially those containing villin-type headpiece domains) and lipid binding proteins including apolipoprotein B, the essential protein component of low density lipoprotein (LDL, the bad cholesterol) whose elevated levels are correlated with atherosclerosis, stroke, heart and cardiovascular disease.
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