Keywords
Last Name

Donald M. Small, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics
Address700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Phone(617) 638-4001
ORCID ORCID Icon0000-0002-3072-243X
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentBiochemistry

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine

 Research Expertise & Professional Interests
Dr. Small founded of the Department of Biophysics at Boston University School of Medicine and served as its Chair form 1988 to 2000. After merger with the Department of Physiology in 2000, he served as Chair of Physiology and Biophysics until 2006 when he passed the Chair to Dr. David Atkinson. In 1980 he initiated this Program Project (HL026335) and was Program Director from 1980 to 2001. He has been the Director of Project 2 since its inception. Thus he has a long experience with the Program Project, its changes and advances throughout the past 30 years. Dr. Small, after completing a residency in internal medicine, was trained as a physical chemist with expertise in the study of bulk and surface properties of lipids. Between 1966 and 1978, he studied the physical chemistry of bile lipids. He defined the solubility of cholesterol in phospholipid/bile salt micelles (1), and related it to human bile composition and gallstone formation (2). This ignited a whole field of gallstone research which culminated in translation to drug therapy in patients to dissolve and prevent stones. His interest turned to atherosclerosis and in 1974 published a seminal paper in Science on the physical-chemical basis of lipid deposition in atherosclerosis (3). In 1986 he was selected by the AHA to give the Duff Lecture on his extensive work on the physical-biochemistry of atherosclerotic lesions. Lipoproteins and their apolipoproteins also became a target of his research and along with colleagues he discovered the order/disorder phase transition in cholesterol esters in LDL (4), the irreversible denaturation transition of apo-B on LDL (4), and unfolding transitions in apo-A1, both as a free protein and on lipid particles (5). Over 40 years he and his colleagues have studied the physical biochemistry of lipoproteins, and throughout this period he also published over 50 studies on the physical behavior of a variety of lipids. In 1986 he published, “The Physical Chemistry of Lipids, From Alkanes to Phospholipids,” a highly acclaimed 672 page source book.

By 1990 he began to explore how the primary sequence of apo-B related to its structure and how this drove the assembly with lipids to form nascent VLDL as apoB translocated across the ER. Project 2 was initiated first to study the lipoproteins secreted from cells transfected with C-terminal truncations of apo-B. In 1994, Robert Nolte (a student of Dr. Atkinson) and Dr. Jere Segrest independently showed that apoB100 and an a/?-?1-a1-?2-a2 secondary structure. In 1997, Drs. Small and Atkinson presented a more detailed model for the ?1 domain of apoB (apoB21-41) as an amphipathic beta sheet 50-60Å wide and 200Å long which could recruit triglycerides into nascent lipoproteins. He then showed that this ? region was responsible for recruiting triacylglycerol to the nascent particle during its translocation across the ER in cells. Since apolipoproteins are interfacial molecules, he pioneered a method to study the binding and surface properties of peptides and apolipoproteins to a drop of core lipid, e.g. triaclyglycerol. He showed that surface behavior of apolipoproteins were very different from the usual globular peptides which denature at surfaces. Amphipathic alpha helical peptides such as HDL apolipoproteins (apo-A1, apo-C1, etc.) bound TAG but could be pushed off into the aqueous phase at a specific pressure without being denatured. In contrast, amphipathic beta strands and native parts of the ?1 sheet region from apo-B bound irreversibly and had pure elastic properties and thus provided an anchor for apo-B at the nascent VLDL surface. Recently using an innovative combination of Langmuir balance and tensiometer studies and application of the Gibbs 2D phase rule, he was able to coat the surface with phosphatdylcholine (PC) to produce a more native lipoprotein-like surface. Here the concentration or surface density of PC and TAG is known and can be varied as a function of pressure. Ongoing studies of various apoproteins and peptides at PC-TO/W interfaces provide a unique opportunity of studying their absorption, potential for desorption, elasticity and other properties at a more physiologic interface.


 Self-Described Keywords
  • apoproteins
  • atherosclerosis
  • lipids
  • peptides
  • phospholipids
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Heiser D, Tan YS, Kaplan I, Godsey B, Morisot S, Cheng WC, Small D, Civin CI. Correlated miR-mRNA Expression Signatures of Mouse Hematopoietic Stem and Progenitor Cell Subsets Predict "Stemness" and "Myeloid" Interaction Networks. PLoS One. 2014; 9(4):e94852.
    View in: PubMed
  2. Mitsche MA, Packer LE, Brown JW, Jiang ZG, Small DM, McKnight CJ. Surface Tensiometry of Apolipoprotein B Domains at Lipid Interfaces Suggests a New Model for the Initial Steps in Triglyceride-rich Lipoprotein Assembly. J Biol Chem. 2014 Mar 28; 289(13):9000-12.
    View in: PubMed
  3. Kats LM, Reschke M, Taulli R, Pozdnyakova O, Burgess K, Bhargava P, Straley K, Karnik R, Meissner A, Small D, Su SM, Yen K, Zhang J, Pandolfi PP. Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance. Cell Stem Cell. 2014 Mar 6; 14(3):329-41.
    View in: PubMed
  4. Wang L, Mei X, Atkinson D, Small DM. Surface behavior of apolipoprotein A-I and its deletion mutants at model lipoprotein interfaces. J Lipid Res. 2014 Mar; 55(3):478-92.
    View in: PubMed
  5. Meyers NL, Wang L, Gursky O, Small DM. Changes in helical content or net charge of apolipoprotein C-I alter its affinity for lipid/water interfaces. J Lipid Res. 2013 Jul; 54(7):1927-38.
    View in: PubMed
  6. Mitsche MA, Small DM. Surface pressure-dependent conformation change of apolipoprotein-derived amphipathic a-helices. J Lipid Res. 2013 Jun; 54(6):1578-88.
    View in: PubMed
  7. Kim KT, Carroll AP, Mashkani B, Cairns MJ, Small D, Scott RJ. MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1. PLoS One. 2012; 7(9):e44546.
    View in: PubMed
  8. McCall CM, Mudali S, Arceci RJ, Small D, Fuller S, Gocke CD, Vuica-Ross M, Burns KH, Borowitz MJ, Duffield AS. Flow cytometric findings in hemophagocytic lymphohistiocytosis. Am J Clin Pathol. 2012 May; 137(5):786-94.
    View in: PubMed
  9. Meyers NL, Wang L, Small DM. Apolipoprotein C-I binds more strongly to phospholipid/triolein/water than triolein/water interfaces: a possible model for inhibiting cholesterol ester transfer protein activity and triacylglycerol-rich lipoprotein uptake. Biochemistry. 2012 Feb 14; 51(6):1238-48.
    View in: PubMed
  10. Mitsche MA, Small DM. C-terminus of apolipoprotein A-I removes phospholipids from a triolein/phospholipids/water interface, but the N-terminus does not: a possible mechanism for nascent HDL assembly. Biophys J. 2011 Jul 20; 101(2):353-61.
    View in: PubMed
  11. Wang L, Jiang ZG, McKnight CJ, Small DM. Interfacial properties of apolipoprotein B292-593 (B6.4-13) and B611-782 (B13-17). Insights into the structure of the lipovitellin homology region in apolipoprotein B. Biochemistry. 2010 May 11; 49(18):3898-907.
    View in: PubMed
  12. Mitsche MA, Wang L, Small DM. Adsorption of egg phosphatidylcholine to an air/water and triolein/water bubble interface: use of the 2-dimensional phase rule to estimate the surface composition of a phospholipid/triolein/water surface as a function of surface pressure. J Phys Chem B. 2010 Mar 11; 114(9):3276-84.
    View in: PubMed
  13. Wang L, Martin DD, Genter E, Wang J, McLeod RS, Small DM. Surface study of apoB1694-1880, a sequence that can anchor apoB to lipoproteins and make it nonexchangeable. J Lipid Res. 2009 Jul; 50(7):1340-52.
    View in: PubMed
  14. Mitsche MA, Wang L, Jiang ZG, McKnight CJ, Small DM. Interfacial properties of a complex multi-domain 490 amino acid peptide derived from apolipoprotein B (residues 292-782). Langmuir. 2009 Feb 17; 25(4):2322-30.
    View in: PubMed
  15. Small DM, Wang L, Mitsche MA. The adsorption of biological peptides and proteins at the oil/water interface. A potentially important but largely unexplored field. J Lipid Res. 2009 Apr; 50 Suppl:S329-34.
    View in: PubMed
  16. Wang L, Hua N, Atkinson D, Small DM. The N-terminal (1-44) and C-terminal (198-243) peptides of apolipoprotein A-I behave differently at the triolein/water interface. Biochemistry. 2007 Oct 30; 46(43):12140-51.
    View in: PubMed
  17. Brown P, McIntyre E, Rau R, Meshinchi S, Lacayo N, Dahl G, Alonzo TA, Chang M, Arceci RJ, Small D. The incidence and clinical significance of nucleophosmin mutations in childhood AML. Blood. 2007 Aug 1; 110(3):979-85.
    View in: PubMed
  18. Wang L, Walsh MT, Small DM. Apolipoprotein B is conformationally flexible but anchored at a triolein/water interface: a possible model for lipoprotein surfaces. Proc Natl Acad Sci U S A. 2006 May 2; 103(18):6871-6.
    View in: PubMed
  19. Wang L, Atkinson D, Small DM. The interfacial properties of ApoA-I and an amphipathic alpha-helix consensus peptide of exchangeable apolipoproteins at the triolein/water interface. J Biol Chem. 2005 Feb 11; 280(6):4154-65.
    View in: PubMed
  20. Wang L, Small DM. Interfacial properties of amphipathic beta strand consensus peptides of apolipoprotein B at oil/water interfaces. J Lipid Res. 2004 Sep; 45(9):1704-15.
    View in: PubMed
  21. Wang L, Atkinson D, Small DM. Interfacial properties of an amphipathic alpha-helix consensus peptide of exchangeable apolipoproteins at air/water and oil/water interfaces. J Biol Chem. 2003 Sep 26; 278(39):37480-91.
    View in: PubMed
  22. Hoare K, Hoare S, Smith OM, Kalmaz G, Small D, Stratford May W. Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling. Oncogene. 2003 Jun 5; 22(23):3562-77.
    View in: PubMed
  23. Small DM. Role of ABC transporters in secretion of cholesterol from liver into bile. Proc Natl Acad Sci U S A. 2003 Jan 7; 100(1):4-6.
    View in: PubMed
  24. Duggan A, Paolucci M, Tercyak A, Gigliotti M, Small D, Callard I. Seasonal variation in plasma lipids, lipoproteins, apolipoprotein A-I and vitellogenin in the freshwater turtle, Chrysemys picta. Comp Biochem Physiol A Mol Integr Physiol. 2001 Sep; 130(2):253-69.
    View in: PubMed
  25. Haimovici R, Gantz DL, Rumelt S, Freddo TF, Small DM. The lipid composition of drusen, Bruch's membrane, and sclera by hot stage polarizing light microscopy. Invest Ophthalmol Vis Sci. 2001 Jun; 42(7):1592-9.
    View in: PubMed
  26. Sato K, Goto M, Yano J, Honda K, Kodali DR, Small DM. Atomic resolution structure analysis of beta' polymorph crystal of a triacylglycerol: 1,2-dipalmitoyl-3-myristoyl-sn-glycerol. J Lipid Res. 2001 Mar; 42(3):338-45.
    View in: PubMed
  27. Herscovitz H, Derksen A, Walsh MT, McKnight CJ, Gantz DL, Hadzopoulou-Cladaras M, Zannis V, Curry C, Small DM. The N-terminal 17% of apoB binds tightly and irreversibly to emulsions modeling nascent very low density lipoproteins. J Lipid Res. 2001 Jan; 42(1):51-9.
    View in: PubMed
  28. Gantz DL, Walsh MT, Small DM. Morphology of sodium deoxycholate-solubilized apolipoprotein B-100 using negative stain and vitreous ice electron microscopy. J Lipid Res. 2000 Sep; 41(9):1464-72.
    View in: PubMed
  29. Carraway M, Herscovitz H, Zannis V, Small DM. Specificity of lipid incorporation is determined by sequences in the N-terminal 37 of apoB. Biochemistry. 2000 Aug 15; 39(32):9737-45.
    View in: PubMed
  30. Hindenes JO, Nerdal W, Guo W, Di L, Small DM, Holmsen H. Physical properties of the transmembrane signal molecule, sn-1-stearoyl 2-arachidonoylglycerol. Acyl chain segregation and its biochemical implications. J Biol Chem. 2000 Mar 10; 275(10):6857-67.
    View in: PubMed
  31. Prudovsky I, Landriscina M, Soldi R, Bellum S, Small D, Andreeva V, Maciag T. Fusions to members of fibroblast growth factor gene family to study nuclear translocation and nonclassic exocytosis. Methods Enzymol. 2000; 327:369-82.
    View in: PubMed
  32. Gantz DL, Wang DQ, Carey MC, Small DM. Cryoelectron microscopy of a nucleating model bile in vitreous ice: formation of primordial vesicles. Biophys J. 1999 Mar; 76(3):1436-51.
    View in: PubMed
  33. Yano J, Sato K, Kaneko F, Small DM, Kodali DR. Structural analyses of polymorphic transitions of sn-1, 3-distearoyl-2-oleoylglycerol (SOS) and sn-1, 3-dioleoyl-2-stearoylglycerol (OSO): assessment on steric hindrance of unsaturated and saturated acyl chain interactions. J Lipid Res. 1999 Jan; 40(1):140-51.
    View in: PubMed
  34. Small DM. Potpourri: effects of unsaturation on lipid structure; plasma cholesterol ester and lipid-transfer proteins; and cholesterol-sensing proteins and cellular cholesterol movement. Curr Opin Struct Biol. 1998 Aug; 8(4):413-6.
    View in: PubMed
  35. Ko J, Small DM. Behavior of tetrahydrolipstatin in biological model membranes and emulsions. J Lipid Res. 1997 Aug; 38(8):1544-52.
    View in: PubMed
  36. McCauliffe DP, Wang L, Satoh M, Reeves WH, Small D. Recombinant 52 kDa Ro(SSA) ELISA detects autoantibodies in Sjögren's syndrome sera that go undetected by conventional serologic assays. J Rheumatol. 1997 May; 24(5):860-6.
    View in: PubMed
  37. Small DM. Point mutations in the ileal bile salt transporter cause leaks in the enterohepatic circulation leading to severe chronic diarrhea and malabsorption. J Clin Invest. 1997 Apr 15; 99(8):1807-8.
    View in: PubMed
  38. Small DM. Physical behavior of lipase substrates. Methods Enzymol. 1997; 286:153-67.
    View in: PubMed
  39. McNamara JR, Small DM, Li Z, Schaefer EJ. Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B. J Lipid Res. 1996 Sep; 37(9):1924-35.
    View in: PubMed
  40. Small DM. Switch blades, straight performers and distortion by enzymes. Curr Opin Struct Biol. 1996 Aug; 6(4):429-31.
    View in: PubMed
  41. Boyle E, Small DM, Gantz D, Hamilton JA, German JB. Monoacylglycerols alter the lipid composition and molecular mobility of phosphatidylcholine bilayers: 13C NMR evidence of dynamic lipid remodeling. J Lipid Res. 1996 Apr; 37(4):764-72.
    View in: PubMed
  42. Hoehn GT, Stokland T, Amin S, Ramírez M, Hawkins AL, Griffin CA, Small D, Civin CI. Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells. Oncogene. 1996 Feb 15; 12(4):903-13.
    View in: PubMed
  43. Derksen A, Gantz D, Small DM. Calorimetry of apolipoprotein-A1 binding to phosphatidylcholine-triolein-cholesterol emulsions. Biophys J. 1996 Jan; 70(1):330-8.
    View in: PubMed
  44. Di L, Small DM. Physical behavior of the hydrophobic core of membranes: properties of 1-stearoyl-2-linoleoyl-sn-glycerol. Biochemistry. 1995 Dec 26; 34(51):16672-7.
    View in: PubMed
  45. Goto M, Honda K, Di L, Small DM. Crystal structure of a mixed chain diacylglycerol, 1-stearoyl-3-oleyl-glycerol. J Lipid Res. 1995 Oct; 36(10):2185-90.
    View in: PubMed
  46. Afdhal NH, Niu N, Nunes DP, Bansil R, Cao XX, Gantz D, Small DM, Offner GD. Mucin-vesicle interactions in model bile: evidence for vesicle aggregation and fusion before cholesterol crystal formation. Hepatology. 1995 Sep; 22(3):856-65.
    View in: PubMed
  47. Herscovitz H, Kritis A, Talianidis I, Zanni E, Zannis V, Small DM. Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich core. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):659-63.
    View in: PubMed
  48. Ko J, Hamilton JA, Ton-Nu HT, Schteingart CD, Hofmann AF, Small DM. Effects of side chain length on ionization behavior and transbilayer transport of unconjugated dihydroxy bile acids: a comparison of nor-chenodeoxycholic acid and chenodeoxycholic acid. J Lipid Res. 1994 May; 35(5):883-92.
    View in: PubMed
  49. Loree HM, Tobias BJ, Gibson LJ, Kamm RD, Small DM, Lee RT. Mechanical properties of model atherosclerotic lesion lipid pools. Arterioscler Thromb. 1994 Feb; 14(2):230-4.
    View in: PubMed
  50. Tangirala RK, Jerome WG, Jones NL, Small DM, Johnson WJ, Glick JM, Mahlberg FH, Rothblat GH. Formation of cholesterol monohydrate crystals in macrophage-derived foam cells. J Lipid Res. 1994 Jan; 35(1):93-104.
    View in: PubMed
  51. Di L, Small DM. Physical behavior of the mixed chain diacylglycerol, 1-stearoyl-2-oleoyl-sn-glycerol: difficulties in chain packing produced marked polymorphism. J Lipid Res. 1993 Sep; 34(9):1611-23.
    View in: PubMed
  52. Moarefi IF, Small D, Gilbert I, Höpfner M, Randall SK, Schneider C, Russo AA, Ramsperger U, Arthur AK, Stahl H, et al. Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding. J Virol. 1993 Aug; 67(8):4992-5002.
    View in: PubMed
  53. Afdhal NH, Niu N, Gantz D, Small DM, Smith BF. Bovine gallbladder mucin accelerates cholesterol monohydrate crystal growth in model bile. Gastroenterology. 1993 May; 104(5):1515-23.
    View in: PubMed
  54. Small DM. 1992 Aspen Bile Acid/Cholesterol/Lipoprotein Conference. Report of a conference. J Lipid Res. 1993 Apr; 34(4):680-7.
    View in: PubMed
  55. Small DM. Do dietary fatty acids affect the biophysics of platelet-membrane function in thrombosis? Am J Clin Nutr. 1992 Oct; 56(4 Suppl):799S-800S.
    View in: PubMed
  56. Konikoff FM, Chung DS, Donovan JM, Small DM, Carey MC. Filamentous, helical, and tubular microstructures during cholesterol crystallization from bile. Evidence that cholesterol does not nucleate classic monohydrate plates. J Clin Invest. 1992 Sep; 90(3):1155-60.
    View in: PubMed
  57. Goto M, Kodali DR, Small DM, Honda K, Kozawa K, Uchida T. Single crystal structure of a mixed-chain triacylglycerol: 1,2-dipalmitoyl-3-acetyl-sn-glycerol. Proc Natl Acad Sci U S A. 1992 Sep 1; 89(17):8083-6.
    View in: PubMed
  58. Herscovitz H, Gantz D, Tercyak AM, Zannis VI, Small DM. Expression of human apolipoprotein E but not that of apolipoprotein A-I by mouse C127 cells is associated with increased secretion of lipids in the form of vesicles and discs. J Lipid Res. 1992 Jun; 33(6):791-803.
    View in: PubMed
  59. Herscovitz H, Hadzopoulou-Cladaras M, Walsh MT, Cladaras C, Zannis VI, Small DM. Expression, secretion, and lipid-binding characterization of the N-terminal 17% of apolipoprotein B. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7313-7.
    View in: PubMed
  60. Felker TE, Gantz D, Tercyak AM, Oliva C, Clark SB, Small DM. A comparison of lipoprotein secretion, bile production and hepatic morphology in isolated rat livers perfused with a perfluorocarbon emulsion or rat erythrocytes. Hepatology. 1991 Aug; 14(2):340-51.
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  61. Cistola DP, Small DM. Fatty acid distribution in systems modeling the normal and diabetic human circulation. A 13C nuclear magnetic resonance study. J Clin Invest. 1991 Apr; 87(4):1431-41.
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  62. Hamilton JA, Bhamidipati SP, Kodali DR, Small DM. The interfacial conformation and transbilayer movement of diacylglycerols in phospholipid bilayers. J Biol Chem. 1991 Jan 15; 266(2):1177-86.
    View in: PubMed
  63. Small DM, Oliva C, Tercyak A. Chemistry in the kitchen. Making ground meat more healthful. N Engl J Med. 1991 Jan 10; 324(2):73-7.
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  64. Clark SB, Derksen A, Small DM. Plasma clearance of emulsified triolein in conscious rats: effects of phosphatidylcholine species, cholesterol content and emulsion surface physical state. Exp Physiol. 1991 Jan; 76(1):39-52.
    View in: PubMed
  65. Small DM, Clarke SB, Tercyak A, Steiner J, Gantz D, Derksen A. The lipid surface of triglyceride-rich particles can modulate (apo)protein binding and tissue uptake. Adv Exp Med Biol. 1991; 285:281-8.
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  66. Small DM. The effects of glyceride structure on absorption and metabolism. Annu Rev Nutr. 1991; 11:413-34.
    View in: PubMed
  67. Kodali DR, Fahey DA, Small DM. Structure and polymorphism of saturated monoacid 1,2-diacyl-sn-glycerols. Biochemistry. 1990 Dec 4; 29(48):10771-9.
    View in: PubMed
  68. Kodali DR, Atkinson D, Small DM. Polymorphic behavior of 1,2-dipalmitoyl-3-lauroyl(PP12)- and 3-myristoyl(PP14)-sn-glycerols. J Lipid Res. 1990 Oct; 31(10):1853-64.
    View in: PubMed
  69. Spooner PJ, Gantz DL, Hamilton JA, Small DM. The distribution of oleic acid between chylomicron-like emulsions, phospholipid bilayers, and serum albumin. A model for fatty acid distribution between lipoproteins, membranes, and albumin. J Biol Chem. 1990 Jul 25; 265(21):12650-5.
    View in: PubMed
  70. Nolte CJ, Tercyak AM, Wu HM, Small DM. Chemical and physiochemical comparison of advanced atherosclerotic lesions of similar size and cholesterol content in cholesterol-fed New Zealand White and Watanabe Heritable Hyperlipidemic rabbits. Lab Invest. 1990 Feb; 62(2):213-22.
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  71. Kodali DR, Tercyak A, Fahey DA, Small DM. Acyl migration in 1,2-dipalmitoyl-sn-glycerol. Chem Phys Lipids. 1990 Feb; 52(3-4):163-70.
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  72. Gantz D, Bennett Clark S, Derksen A, Small DM. Size and shape determination of fixed chylomicrons and emulsions with fluid or solid surfaces by three-dimensional analysis of shadows. J Lipid Res. 1990 Jan; 31(1):163-71.
    View in: PubMed
  73. Derksen A, Ekman S, Small DM. Oleic acid allows more apoprotein A-1 to bind with higher affinity to large emulsion particles saturated with cholesterol. J Biol Chem. 1989 Apr 25; 264(12):6935-40.
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  74. Waugh DA, Tercyak AM, Small DM. Physico-chemical properties of cholesterol-fed rabbit beta-VLDL are not affected by different dietary oils. Atherosclerosis. 1989 Apr; 76(2-3):237-43.
    View in: PubMed
  75. Derksen A, Small DM. Interaction of ApoA-1 and ApoE-3 with triglyceride-phospholipid emulsions containing increasing cholesterol concentrations. Model of triglyceride-rich nascent and remnant lipoproteins. Biochemistry. 1989 Jan 24; 28(2):900-6.
    View in: PubMed
  76. Ekman S, Derksen A, Small DM. The partitioning of fatty acid and cholesterol between core and surfaces of phosphatidylcholine-triolein emulsions at pH 7.4. Biochim Biophys Acta. 1988 Apr 15; 959(3):343-8.
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  77. Redgrave TG, Kodali DR, Small DM. The effect of triacyl-sn-glycerol structure on the metabolism of chylomicrons and triacylglycerol-rich emulsions in the rat. J Biol Chem. 1988 Apr 15; 263(11):5118-23.
    View in: PubMed
  78. Cistola DP, Hamilton JA, Jackson D, Small DM. Ionization and phase behavior of fatty acids in water: application of the Gibbs phase rule. Biochemistry. 1988 Mar 22; 27(6):1881-8.
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  79. Small DM. George Lyman Duff memorial lecture. Progression and regression of atherosclerotic lesions. Insights from lipid physical biochemistry. Arteriosclerosis. 1988 Mar-Apr; 8(2):103-29.
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  80. Spooner PJ, Clark SB, Gantz DL, Hamilton JA, Small DM. The ionization and distribution behavior of oleic acid in chylomicrons and chylomicron-like emulsion particles and the influence of serum albumin. J Biol Chem. 1988 Jan 25; 263(3):1444-53.
    View in: PubMed
  81. Walsh MT, Hamilton JA, Atkinson D, Small DM. Secondary and tertiary structure of apolipoproteins. Adv Exp Med Biol. 1988; 243:123-32.
    View in: PubMed
  82. Small DM. Mechanisms of reversed cholesterol transport. Agents Actions Suppl. 1988; 26:135-46.
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  83. Spooner PJ, Small DM. Effect of free cholesterol on incorporation of triolein in phospholipid bilayers. Biochemistry. 1987 Sep 8; 26(18):5820-5.
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  84. Cistola DP, Small DM, Hamilton JA. Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. I. The filling of individual fatty acid binding sites. J Biol Chem. 1987 Aug 15; 262(23):10971-9.
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  85. Cistola DP, Small DM, Hamilton JA. Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. II. Electrostatic interactions in individual fatty acid binding sites. J Biol Chem. 1987 Aug 15; 262(23):10980-5.
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  86. Cabral DJ, Small DM, Lilly HS, Hamilton JA. Transbilayer movement of bile acids in model membranes. Biochemistry. 1987 Apr 7; 26(7):1801-4.
    View in: PubMed
  87. Kodali DR, Atkinson D, Redgrave TG, Small DM. Structure and polymorphism of 18-carbon fatty acyl triacylglycerols: effect of unsaturation and substitution in the 2-position. J Lipid Res. 1987 Apr; 28(4):403-13.
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  88. Pittman RC, Glass CK, Atkinson D, Small DM. Synthetic high density lipoprotein particles. Application to studies of the apoprotein specificity for selective uptake of cholesterol esters. J Biol Chem. 1987 Feb 25; 262(6):2435-42.
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  89. Smith BF, LaMont JT, Small DM. The sequence of events in gallstone formation. Lab Invest. 1987 Feb; 56(2):125-6.
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  90. Spooner PJ, Hamilton JA, Gantz DL, Small DM. The effect of free cholesterol on the solubilization of cholesteryl oleate in phosphatidylcholine bilayers: A 13C-NMR study. Biochim Biophys Acta. 1986 Aug 21; 860(2):345-53.
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  91. Fahey DA, Small DM. Surface properties of 1,2-dipalmitoyl-3-acyl-sn-glycerols. Biochemistry. 1986 Jul 29; 25(15):4468-72.
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  92. Cistola DP, Atkinson D, Hamilton JA, Small DM. Phase behavior and bilayer properties of fatty acids: hydrated 1:1 acid-soaps. Biochemistry. 1986 May 20; 25(10):2804-12.
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  93. Cabral DJ, Hamilton JA, Small DM. The ionization behavior of bile acids in different aqueous environments. J Lipid Res. 1986 Mar; 27(3):334-43.
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  94. Atkinson D, Small DM. Recombinant lipoproteins: implications for structure and assembly of native lipoproteins. Annu Rev Biophys Biophys Chem. 1986; 15:403-56.
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  95. Croll DH, Small DM, Hamilton JA. Molecular motions and thermotropic phase behavior of cholesteryl esters with triolein. Biochemistry. 1985 Dec 31; 24(27):7971-80.
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  96. Fahey DA, Small DM, Kodali DR, Atkinson D, Redgrave TG. Structure and polymorphism of 1,2-dioleoyl-3-acyl-sn-glycerols. Three- and six-layered structures. Biochemistry. 1985 Jul 2; 24(14):3757-64.
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  97. Kodali DR, Redgrave TG, Small DM, Atkinson D. Synthesis and polymorphism of 3-acyl-sn-glycerols. Biochemistry. 1985 Jan 15; 24(2):519-25.
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  98. Small DM. Lateral chain packing in lipids and membranes. J Lipid Res. 1984 Dec 15; 25(13):1490-500.
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  99. Waugh DA, Small DM. Identification and detection of in situ cellular and regional differences of lipid composition and class in lipid-rich tissue using hot stage polarizing light microscopy. Lab Invest. 1984 Dec; 51(6):702-14.
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  100. Small DM, Cabral DJ, Cistola DP, Parks JS, Hamilton JA. The ionization behavior of fatty acids and bile acids in micelles and membranes. Hepatology. 1984 Sep-Oct; 4(5 Suppl):77S-79S.
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  101. Hamilton JA, Cistola DP, Morrisett JD, Sparrow JT, Small DM. Interactions of myristic acid with bovine serum albumin: a 13C NMR study. Proc Natl Acad Sci U S A. 1984 Jun; 81(12):3718-22.
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  102. Small DM, Bond MG, Waugh D, Prack M, Sawyer JK. Physicochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis. J Clin Invest. 1984 Jun; 73(6):1590-605.
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  103. Ginsburg GS, Walsh MT, Small DM, Atkinson D. Reassembled plasma low density lipoproteins. Phospholipid-cholesterol ester-apoprotein B complexes. J Biol Chem. 1984 May 25; 259(10):6667-73.
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  104. Martin RS, Small DM. Physicochemical characterization of the urinary lipid from humans with nephrotic syndrome. J Lab Clin Med. 1984 May; 103(5):798-810.
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  105. Ginsburg GS, Atkinson D, Small DM. Physical properties of cholesteryl esters. Prog Lipid Res. 1984; 23(3):135-67.
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  106. Miller KW, Small DM. Surface-to-core and interparticle equilibrium distributions of triglyceride-rich lipoprotein lipids. J Biol Chem. 1983 Nov 25; 258(22):13772-84.
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  107. Hamilton JA, Miller KW, Small DM. Solubilization of triolein and cholesteryl oleate in egg phosphatidylcholine vesicles. J Biol Chem. 1983 Nov 10; 258(21):12821-6.
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  108. Brecher P, Chobanian AV, Small DM, Van Sickle W, Tercyak A, Lazzari A, Baler J. Relationship of an abnormal plasma lipoprotein to protection from atherosclerosis in the cholesterol-fed diabetic rabbit. J Clin Invest. 1983 Nov; 72(5):1553-62.
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  109. Parks JS, Cistola DP, Small DM, Hamilton JA. Interactions of the carboxyl group of oleic acid with bovine serum albumin: a 13C NMR study. J Biol Chem. 1983 Aug 10; 258(15):9262-9.
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  110. Vakakis N, Redgrave TG, Small DM, Castelli WP. Cholesterol content of red blood cells and low-density lipoproteins in hypertriglyceridemia. Biochim Biophys Acta. 1983 May 16; 751(3):280-5.
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  111. Hamilton JA, Small DM, Parks JS. 1H NMR studies of lymph chylomicra and very low density lipoproteins from nonhuman primates. J Biol Chem. 1983 Jan 25; 258(2):1172-9.
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  112. Miller KW, Small DM. Triolein-cholesteryl oleate-cholesterol-lecithin emulsions: structural models of triglyceride-rich lipoproteins. Biochemistry. 1983 Jan 18; 22(2):443-51.
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  113. Carey MC, Small DM, Bliss CM. Lipid digestion and absorption. Annu Rev Physiol. 1983; 45:651-77.
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  114. Ginsburg GS, Small DM, Hamilton JA. Temperature-dependent molecular motions of cholesterol esters: a carbon-13 nuclear magnetic resonance study. Biochemistry. 1982 Dec 21; 21(26):6857-67.
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  115. Sanborn TA, Faxon DP, Waugh D, Small DM, Haudenschild C, Gottsman SB, Ryan TJ. Transluminal angioplasty in experimental atherosclerosis. Analysis for embolization using an in vivo perfusion system. Circulation. 1982 Nov; 66(5):917-22.
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  116. Ginsburg GS, Small DM, Atkinson D. Microemulsions of phospholipids and cholesterol esters. Protein-free models of low density lipoprotein. J Biol Chem. 1982 Jul 25; 257(14):8216-27.
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  117. Hamilton JA, Small DM. Solubilization and localization of cholesteryl oleate in egg phosphatidylcholine vesicles. A carbon 13 NMR study. J Biol Chem. 1982 Jul 10; 257(13):7318-21.
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  118. Cistola DP, Small DM, Hamilton JA. Ionization behavior of aqueous short-chain carboxylic acids: a carbon-13 NMR study. J Lipid Res. 1982 Jul; 23(5):795-9.
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  119. Katz SS, Small DM, Smith FR, Dell RB, Goodman DS. Cholesterol turnover in lipid phases of human atherosclerotic plaque. J Lipid Res. 1982 Jul; 23(5):733-7.
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  120. Lichtenstein AH, Small DM, Brecher P. Interaction of oleoyl coenzyme A with phospholipid bilayers. Biochemistry. 1982 Apr 27; 21(9):2233-41.
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  121. Albers JJ, Grundy SM, Cleary PA, Small DM, Lachin JM, Schoenfield LJ. National Cooperative Gallstone Study: the effect of chenodeoxycholic acid on lipoproteins and apolipoproteins. Gastroenterology. 1982 Apr; 82(4):638-46.
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  122. Strasberg SM, Redinger RN, Small DM, Egdahl RH. The effect of elevated biliary tract pressure on biliary lipid metabolism and bile flow in nonhuman primates. J Lab Clin Med. 1982 Mar; 99(3):342-53.
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  123. Yau-Young AO, Rothblat GH, Small DM. Mobilization of cholesterol from cholesterol ester-enriched tissue culture cells by phospholipid dispersions. Biochim Biophys Acta. 1982 Feb 15; 710(2):181-7.
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  124. Waugh DA, Small DM. Rapid method for determining cholesteryl ester transitions of apoB-containing lipoproteins. J Lipid Res. 1982 Jan; 23(1):201-4.
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  125. Clark SB, Atkinson D, Hamilton JA, Forte T, Russell B, Feldman EB, Small DM. Physical studies of d less than 1.006 g/ml lymph lipoproteins from rats fed palmitate-rich diets. J Lipid Res. 1982 Jan; 23(1):28-41.
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  126. Parks JS, Atkinson D, Small DM, Rudel LL. Physical characterization of lymph chylomicrons and very low density lipoproteins from nonhuman primates fed saturated dietary fat. J Biol Chem. 1981 Dec 25; 256(24):12992-9.
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  127. Hamilton JA, Small DM. Solubilization and localization of triolein in phosphatidylcholine bilayers: a 13C NMR study. Proc Natl Acad Sci U S A. 1981 Nov; 78(11):6878-82.
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  128. Clark SB, Clark VE, Small DM. Effects of lecithin ingestion on plasma and lymph lipoproteins of normo- and hyperlipemic rats. Am J Physiol. 1981 Nov; 241(5):G422-30.
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  129. Ruocco MJ, Atkinson D, Small DM, Skarjune RP, Oldfield E, Shipley GG. X-ray diffraction and calorimetric study of anhydrous and hydrated N-palmitoylgalactosylsphingosine (cerebroside). Biochemistry. 1981 Oct 13; 20(21):5957-66.
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  130. Ginsburg GS, Small DM. Physical properties of cholesteryl esters having 20 carbons or more. Biochim Biophys Acta. 1981 Apr 23; 664(1):98-107.
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  131. Tall AR, Puppione DL, Kunitake ST, Atkinson D, Small DM, Waugh D. Organization of the core lipids of high density lipoproteins in the lactating bovine. J Biol Chem. 1981 Jan 10; 256(1):170-4.
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  132. Katz SS, Small DM. Isolation and and partial characterization of the lipid phases of human atherosclerotic plaques. J Biol Chem. 1980 Oct 25; 255(20):9753-9.
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  133. Small DM. Cholesterol nucleation and growth in gallstone formation. N Engl J Med. 1980 Jun 5; 302(23):1305-7.
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  134. Atkinson D, Small DM, Shipley GG. X-ray and neutron scattering studies of plasma lipoproteins. Ann N Y Acad Sci. 1980; 348:284-98.
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  135. Tall AR, Small DM. Body cholesterol removal: role of plasma high-density lipoproteins. Adv Lipid Res. 1980; 17:1-51.
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  136. Small DM, Bernstein M. Sauce Béarnaise. N Engl J Med. 1979 Aug 2; 301(5):276-7.
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  137. Janiak MJ, Small DM, Shipley GG. Temperature and compositional dependence of the structure of hydrated dimyristoyl lecithin. J Biol Chem. 1979 Jul 10; 254(13):6068-78.
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  138. Redgrave TG, Small DM. Quantitation of the transfer of surface phospholipid of chylomicrons to the high density lipoprotein fraction during the catabolism of chylomicrons in the rat. J Clin Invest. 1979 Jul; 64(1):162-71.
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  139. Loomis CR, Shipley GG, Small DM. The phase behavior of hydrated cholesterol. J Lipid Res. 1979 May; 20(4):525-35.
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  140. Small DM, Bernstein M. Doctor in the kitchen: experiments on sauce Béarnaise. N Engl J Med. 1979 Apr 5; 300(14):801-2.
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  141. Ros E, Small DM, Carey MC. Effects of chlorpromazine hydrochloride on bile salt synthesis, bile formation and biliary lipid secretion in the rhesus monkey: a model for chlorpromazine-induced cholestasis. Eur J Clin Invest. 1979 Feb; 9(1):29-41.
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  142. Janiak MJ, Small DM, Shipley GG. Interactions of cholesterol esters with phospholipids: cholesteryl myristate and dimyristoyl lecithin. J Lipid Res. 1979 Feb; 20(2):183-99.
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  143. Curatolo W, Yau AO, Small DM, Sears B. Lectin-induced agglutination of phospholipid/glycolipid vesicles. Biochemistry. 1978 Dec 26; 17(26):5740-4.
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  144. Tall AR, Small DM, Atkinson D, Rudel LL. Studies on the structure of low density lipoproteins isolated from Macaca fascicularis fed an atherogenic diet. J Clin Invest. 1978 Dec; 62(6):1354-63.
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  145. Tall AR, Small DM. Plasma high-density lipoproteins. N Engl J Med. 1978 Nov 30; 299(22):1232-6.
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  146. Tall AR, Small DM, Lees RS. Interaction of collagen with the lipids of tendon xanthomata. J Clin Invest. 1978 Oct; 62(4):836-46.
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  147. Atkinson D, Tall AR, Small DM, Mahley RW. Structural organization of the lipoprotein HDLc from atherosclerotic swine. Structural features relating the particle surface and core. Biochemistry. 1978 Sep 19; 17(19):3930-3.
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  148. North BE, Katz SS, Small DM. The dissolution of cholesterol monohydrate crystals in atherosclerotic plaque lipids. Atherosclerosis. 1978 Jul; 30(3):211-7.
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  149. Curatolo W, Verma SP, Sakura JD, Small DM, Shipley GG, Wallach DF. Structural effects of myelin proteolipid apoprotein on phospholipids: a Raman spectroscopic study. Biochemistry. 1978 May 2; 17(9):1802-7.
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  150. Carey MC, Small DM. The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man. J Clin Invest. 1978 Apr; 61(4):998-1026.
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  151. Tall AR, Hogan V, Askinazi L, Small DM. Interaction of plasma high density lipoproteins with dimyristoyllecithin multilamellar liposomes. Biochemistry. 1978 Jan 24; 17(2):322-6.
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  152. Small DM. Cellular mechanisms for lipid deposition in atherosclerosis (second of two parts). N Engl J Med. 1977 Oct 27; 297(17):924-9.
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  153. Tall AR, Atkinson D, Small DM, Mahley RW. Characterization of the lipoproteins of atherosclerotic swine. J Biol Chem. 1977 Oct 25; 252(20):7288-93.
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  154. Small DM. Cellular mechanisms for lipid deposition in atherosclerosis (first of two parts). N Engl J Med. 1977 Oct 20; 297(16):873-7.
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  155. Tall AR, Small DM, Deckelbaum RJ, Shipley GG. Structure and thermodynamic properties of high density lipoprotein recombinants. J Biol Chem. 1977 Jul 10; 252(13):4701-11.
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  156. Curatolo W, Small DM, Shipley GG. Phase behavior and structural characteristics of hydrated bovine brain gangliosides. Biochim Biophys Acta. 1977 Jul 4; 468(1):11-20.
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  157. Katz SS, Small DM, Brook JG, Lees RS. The storage lipids in Tangier disease. A physical chemical study. J Clin Invest. 1977 Jun; 59(6):1045-54.
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  158. Curatolo W, Sakura JD, Small DM, Shipley GG. Protein-lipid interactions: recombinants of the proteolipid apoprotein of myelin with dimyristoyllecithin. Biochemistry. 1977 May 31; 16(11):2313-9.
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  159. Shaffer EA, Small DM. Biliary lipid secretion in cholesterol gallstone disease. The effect of cholecystectomy and obesity. J Clin Invest. 1977 May; 59(5):828-40.
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  160. Tall AR, Deckelbaum RJ, Small DM, Shipley GG. Thermal behavior of human plasma high density lipoprotein. Biochim Biophys Acta. 1977 Apr 26; 487(1):145-33.
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  161. Rothblat GH, Rosen JM, Insull W, Yau AO, Small DM. Production of cholesteryl ester-rich, anisotropic inclusions by mammalian cells in culture. Exp Mol Pathol. 1977 Apr; 26(2):318-24.
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  162. Deckelbaum RJ, Lees RS, Small DM, Hedberg SE, Grundy SM. Failure of complete bile diversion and oral bile acid therapy in the treatment of homozygous familial hypercholesterolemia. N Engl J Med. 1977 Mar 3; 296(9):465-70.
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  163. Deckelbaum RJ, Tall AR, Small DM. Interaction of cholesterol ester and triglyceride in human plasma very low density lipoprotein. J Lipid Res. 1977 Mar; 18(2):164-8.
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  164. Atkinson D, Deckelbaum RJ, Small DM, Shipley GG. Structure of human plasma low-density lipoproteins: molecular organization of the central core. Proc Natl Acad Sci U S A. 1977 Mar; 74(3):1042-6.
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  165. Deckelbaum RJ, Shipley GG, Small DM. Structure and interactions of lipids in human plasma low density lipoproteins. J Biol Chem. 1977 Jan 25; 252(2):744-54.
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  166. Tall AR, Small DM. Solubilisation of phospholipid membranes by human plasma high density lipoproteins. Nature. 1977 Jan 13; 265(5590):163-4.
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  167. Janiak MJ, Small DM, Shipley GG. Nature of the Thermal pretransition of synthetic phospholipids: dimyristolyl- and dipalmitoyllecithin. Biochemistry. 1976 Oct 19; 15(21):4575-80.
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  168. Sears B, Deckelbaum RJ, Janiak MJ, Shipley GG, Small DM. Temperature-dependent 13C nuclear magnetic resonance studies of human serum low density lipoproteins. Biochemistry. 1976 Sep 21; 15(19):4151-7.
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  169. Katz SS, Shipley GG, Small DM. Physical chemistry of the lipids of human atherosclerotic lesions. Demonstration of a lesion intermediate between fatty streaks and advanced plaques. J Clin Invest. 1976 Jul; 58(1):200-11.
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  170. Shaffer EA, Small DM. Gallstone disease: pathogenesis and management. Curr Probl Surg. 1976 Jul; 13(7):3-72.
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  171. Tall AR, Shipley GG, Small DM. Conformational and thermodynamic properties of apo A-1 of human plasma high density lipoproteins. J Biol Chem. 1976 Jun 25; 251(12):3749-55.
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  172. Brecher P, Chobanian J, Small DM, Chobanian AV. The use of phospholipid vesicles for in vitro studies on cholesteryl ester hydrolysis. J Lipid Res. 1976 May; 17(3):239-47.
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  173. North BE, Shipley GG, Small DM. The thermal transitions and structural properties of 5alpha-cholestan-3beta-ol esters of aliphatic acids. Biochim Biophys Acta. 1976 Mar 26; 424(3):376-85.
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  174. Carey MC, Hirom PC, Small DM. A study of the physicochemical interactions between biliary lipids and chlorpromazine hydrochloride. Bile-salt precipitation as a mechanism of phenothiazine-induced bile secretory failure. Biochem J. 1976 Mar 1; 153(3):519-31.
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  175. Gardner BN, Small DM. Simultaneous measurement of the pancreatic and biliary response to CCK and secretin. Primate biliary physiology. XIII. Gastroenterology. 1976 Mar; 70(3):403-7.
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  176. Small DM. Editorial: Hormone use to change normal physiology - is the risk worth it? N Engl J Med. 1976 Jan 22; 294(4):219-21.
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  177. Small DM. Part I. The etiology and pathogenesis of gallstones. Adv Surg. 1976; 10:63-85.
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  178. Tall AR, Small DM, Shipley GG, Lees RS. Apoprotein stability and lipid-protein interactions in human plasma high density lipoproteins. Proc Natl Acad Sci U S A. 1975 Dec; 72(12):4940-2.
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  179. Beaudoin M, Carey MC, Small DM. Effects of taurodihydrofusidate, a bile salt analogue, on bile formation and biliary lipid secretion in the rhesus monkey. J Clin Invest. 1975 Dec; 56(6):1431-41.
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  180. Carey MC, Montet JC, Small DM. Surface and solution properties of steroid antibiotics: 3-acetoxylfusidic acid, cephalosporin P1 and helvolic acid. Biochemistry. 1975 Nov 4; 14(22):4896-905.
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  181. Deckelbaum RJ, Shipley GG, Small DM, Lees RS, George PK. Thermal transitions in human plasma low density lipoproteins. Science. 1975 Oct 24; 190(4212):392-4.
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  182. Gardiner BN, Conaway C, Small DM. Effects of secretin and cholecystokinin on relative composition of hepatic bile in rhesus monkeys. Surg Forum. 1975; 26:437-9.
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  183. Small DM, Shipley GG. Physical-chemical basis of lipid deposition in atherosclerosis. Science. 1974 Jul 19; 185(4147):222-9.
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  184. O''Brien JJ, Shaffer EA, Williams LF, Small DM, Lynn J, Wittenberg J. A physiological model to study gallbladder function in primates. Gastroenterology. 1974 Jul; 67(1):119-25.
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  185. Loomis CR, Janiak MJ, Small DM, Shipley GG. The binary phase diagram of lecithin and cholesteryl linolenate. J Mol Biol. 1974 Jun 25; 86(2):309-24.
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  186. Janiak MJ, Loomis CR, Shipley GG, Small DM. The ternary phase diagram of lecithin, cholesteryl linolenate and water: phase behavior and structure. J Mol Biol. 1974 Jun 25; 86(2):325-39.
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  187. Redinger RN, Strasberg SM, Small DM. Primate biliary physiology. IX. Effects of acute biliary obstruction on biliary lipid metabolism in the monkey. Am J Physiol. 1974 Apr; 226(4):776-83.
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  188. Shipley GG, Avecilla LS, Small DM. Phase behavior and structure of aqueous dispersions of sphingomyelin. J Lipid Res. 1974 Mar; 15(2):124-31.
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  189. Carey MC, Small DM. Solution properties of taurine and glycine conjugates of fusidic acid and its derivatives. Biochim Biophys Acta. 1973 Apr 13; 306(1):51-7.
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  190. Redinger RN, Hermann AH, Small DM. Primate biliary physiology. X. Effects of diet and fasting on biliary lipid secretion and relative composition and bile salt metabolism in the rhesus monkey. Gastroenterology. 1973 Apr; 64(4):610-21.
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  191. Redinger RN, Small DM. Primate biliary physiology. 8. The effect of phenobarbital upon bile salt synthesis and pool size, biliary lipid secretion, and bile composition. J Clin Invest. 1973 Jan; 52(1):161-72.
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  192. Shaffer EA, Braasch JW, Small DM. Bile composition at and after surgery in normal persons and patients with gallstones. Influence of cholecystectomy. N Engl J Med. 1972 Dec 28; 287(26):1317-22.
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  193. Redinger RN, Small DM. Bile composition, bile salt metabolism and gallstones. Arch Intern Med. 1972 Oct; 130(4):618-30.
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  194. Carey MC, Small DM. Micelle formation by bile salts. Physical-chemical and thermodynamic considerations. Arch Intern Med. 1972 Oct; 130(4):506-27.
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  195. Small DM. Gallstones: diagnosis and treatment. Postgrad Med. 1972 Jan; 51(1):187-93.
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  196. Dowling RH, Mack E, Small DM. Biliary lipid secretion and bile composition after acute and chronic interruption of the enterohepatic circulation in the Rhesus monkey. IV. Primate biliary physiology. J Clin Invest. 1971 Sep; 50(9):1917-26.
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  197. Strasberg SM, Redinger RN, Dorn BC, Small DM, Egdahl RH. Effects of alteration of biliary pressure on bile composition--a method for study: primate biliary physiology. V. Gastroenterology. 1971 Sep; 61(3):357-62.
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  198. Carey MC, Small DM. Micellar properties of sodium fusidate, a steroid antibiotic structurally resembling the bile salts. J Lipid Res. 1971 Sep; 12(5):604-13.
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  199. Robins SJ, Small DM, Trier JS, Donaldson RM. Localization of fatty acid reesterification in the brush border region of intestinal absorptive cells. Biochim Biophys Acta. 1971 Jun 1; 233(3):550-61.
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  200. Small DM. Prestone gallstone disease--is therapy safe? N Engl J Med. 1971 Jan 28; 284(4):214-5.
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  201. Carey MC, Small DM. The characteristics of mixed micellar solutions with particular reference to bile. Am J Med. 1970 Nov; 49:590-608.
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  202. Small DM, Rapo S. Source of abnormal bile in patients with cholesterol gallstones. N Engl J Med. 1970 Jul 9; 283(2):53-7.
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  203. Dowling RH, Mack E, Small DM. Effects of controlled interruption of the enterohepatic circulation of bile salts by biliary diversion and by ileal resection on bile salt secretion, synthesis, and pool size in the rhesus monkey. J Clin Invest. 1970 Feb; 49(2):232-42.
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  204. Small DM. The formation of gallstones. Adv Intern Med. 1970; 16:243-64.
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  205. Carey MC, Small DM. Micellar properties of dihydroxy and trihydroxy bile salts: effects of counterion and temperature. J Colloid Interface Sci. 1969 Nov; 31(3):382-96.
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  206. Small DM, Penkett SA, Chapman D. Studies on simple and mixed bile salt micelles by nuclear magnetic resonance spectroscopy. Biochim Biophys Acta. 1969 Jan 21; 176(1):178-89.
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  207. Small DM. Gallstones. N Engl J Med. 1968 Sep 12; 279(11):588-93.
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  208. Admirand WH, Small DM. The physicochemical basis of cholesterol gallstone formation in man. J Clin Invest. 1968 May; 47(5):1043-52.
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  209. Small DM. Phase equilibria and structure of dry and hydrated egg lecithin. J Lipid Res. 1967 Nov; 8(6):551-7.
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  210. Bourgès M, Small DM, Dervichian DG. Biophysics of lipid associations. 3. The quaternary systems lecithin-bile salt-cholesterol-water. Biochim Biophys Acta. 1967 Oct 2; 144(2):189-201.
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  211. Bourgès M, Small DM, Dervichian DG. Biophysics of lipidic associations. II. The ternary systems: cholesterol-lecithin-water. Biochim Biophys Acta. 1967 Feb 14; 137(1):157-67.
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  212. Hofmann AF, Small DM. Detergent properties of bile salts: correlation with physiological function. Annu Rev Med. 1967; 18:333-76.
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  213. Small DM, Bourgès MC, Dervichian DG. The biophysics of lipidic associations. I. The ternary systems: lecithin-bile salt-water. Biochim Biophys Acta. 1966 Dec 7; 125(3):563-80.
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  214. Small DM, Bourgès M, Dervichian DG. Ternary and quaternary aqueous systems containing bile salt, lecithin, and cholesterol. Nature. 1966 Aug 20; 211(5051):816-8.
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  215. SMALL DM, COHEN AS, SCHMID K. LIPOPROTEINS OF SYNOVIAL FLUID AS STUDIED BY ANALYTICAL ULTRACENTRIFUGATION. J Clin Invest. 1964 Nov; 43:2070-9.
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