James F. Head, PhD
Emeritus Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, University of Birmingham



Research in our lab focuses on characterizing the molecular details of protein-ligand and protein-protein interactions and the mechanisms by which changes in these interactions regulate physiological processes. These studies have concentrated mainly on the role of the calcium ion in mediating changes in protein-ligand interactions which subsequently may alter protein-protein interactions to modulate function. However, other protein-ligand interactions are also under study including enzyme-effector and protein-protein complexes. X-ray crystallography is a major tool used in these studies.


Multiple Antibiotic Resistance (mar) Regulon
05/17/2013 - 04/30/2014 (PI)
Trustees of Tufts College, Inc NIH NIAID
R01AI056021-29

Multiple Antibiotic Resistance (MAR) Regulon
01/01/2009 - 12/31/2012 (PI)
Trustees of Tufts College, Inc NIH NIAID
R01AI056021

Crystal Structures of Multiple Antibiotic Resistance Proteins
08/08/1999 - 12/31/2006 (PI)
Paratek Pharmaceuticals Inc

Structural Studies on Aequorin
03/01/2000 - 02/29/2004 (PI)
National Science Foundation

Nucleoplasmin & N1: Co-Chaperones in Nucleosome Assembly
01/01/2000 - 12/31/2003 (Co-PI)
NIH/National Institute of General Medical Sciences
5 R01 GM60537 02

Crystal Structures of Multiple Antibiotic Resistance Proteins
08/09/1999 - 08/08/2001 (Co-PI)
PI: Barbara A. Seaton, PhD
Paratek Pharmaceuticals Inc




Yr Title Project-Sub Proj Pubs
2001 MULTIPLE ANTIBIOTIC RESISTANCE REPRESSOR PROTEIN 3P41RR010888-05S1-27 236
2000 MULTIPLE ANTIBIOTIC RESISTANCE REPRESSOR PROTEIN 5P41RR010888-05-27 236
1999 MULTIPLE ANTIBIOTIC RESISTANCE REPRESSOR PROTEIN 5P41RR010888-04-27 236
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Farelli JD, Gumbart JC, Akey IV, Hempstead A, Amyot W, Head JF, McKnight CJ, Isberg RR, Akey CW. IcmQ in the Type 4b secretion system contains an NAD+ binding domain. Structure. 2013 Aug 6; 21(8):1361-73.View Related Profiles. PMID: 23850453; PMCID: PMC3816012; DOI: 10.1016/j.str.2013.05.017;.
  2. Duval V, McMurry LM, Foster K, Head JF, Levy SB. Mutational analysis of the multiple-antibiotic resistance regulator MarR reveals a ligand binding pocket at the interface between the dimerization and DNA binding domains. J Bacteriol. 2013 Aug; 195(15):3341-51. PMID: 23687277; PMCID: PMC3719538; DOI: 10.1128/JB.02224-12;.
  3. van Eijk M, Rynkiewicz MJ, White MR, Hartshorn KL, Zou X, Schulten K, Luo D, Crouch EC, Cafarella TR, Head JF, Haagsman HP, Seaton BA. A unique sugar-binding site mediates the distinct anti-influenza activity of pig surfactant protein D. J Biol Chem. 2012 Aug 3; 287(32):26666-77.View Related Profiles. PMID: 22685299; PMCID: PMC3411006; DOI: 10.1074/jbc.M112.368571;.
  4. Platonova O, Akey IV, Head JF, Akey CW. Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos. Biochemistry. 2011 Sep 20; 50(37):8078-89.View Related Profiles. PMID: 21863821; PMCID: PMC3172369; DOI: 10.1021/bi2006652;.
  5. Shang F, Rynkiewicz MJ, McCormack FX, Wu H, Cafarella TM, Head JF, Seaton BA. Crystallographic complexes of surfactant protein A and carbohydrates reveal ligand-induced conformational change. J Biol Chem. 2011 Jan 7; 286(1):757-65.View Related Profiles. PMID: 21047777; PMCID: PMC3013034; DOI: 10.1074/jbc.M110.175265;.
  6. Hartshorn KL, White MR, Rynkiewicz M, Sorensen G, Holmskov U, Head J, Crouch EC. Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D. Am J Physiol Lung Cell Mol Physiol. 2010 Sep; 299(3):L384-92.View Related Profiles. PMID: 20601494; PMCID: PMC2951070; DOI: 10.1152/ajplung.00096.2010;.
  7. Hartshorn KL, White MR, Smith K, Sorensen G, Kuroki Y, Holmskov U, Head J, Crouch EC. Increasing antiviral activity of surfactant protein d trimers by introducing residues from bovine serum collectins: dissociation of mannan-binding and antiviral activity. Scand J Immunol. 2010 Jul; 72(1):22-30.View Related Profiles. PMID: 20591072; PMCID: PMC3263973; DOI: 10.1111/j.1365-3083.2010.02409.x;.
  8. Seaton BA, Crouch EC, McCormack FX, Head JF, Hartshorn KL, Mendelsohn R. Review: Structural determinants of pattern recognition by lung collectins. Innate Immun. 2010 Jun; 16(3):143-50.View Related Profiles. PMID: 20423923; DOI: 10.1177/1753425910368716;.
  9. Crouch E, Hartshorn K, Horlacher T, McDonald B, Smith K, Cafarella T, Seaton B, Seeberger PH, Head J. Recognition of mannosylated ligands and influenza A virus by human surfactant protein D: contributions of an extended site and residue 343. Biochemistry. 2009 Apr 21; 48(15):3335-45.View Related Profiles. PMID: 19249874; PMCID: PMC2720784; DOI: 10.1021/bi8022703;.
  10. Raychaudhury S, Farelli JD, Montminy TP, Matthews M, Ménétret JF, Duménil G, Roy CR, Head JF, Isberg RR, Akey CW. Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila. Structure. 2009 Apr 15; 17(4):590-601.View Related Profiles. PMID: 19368892; PMCID: PMC2693034; DOI: 10.1016/j.str.2009.02.011;.
Showing 10 of 59 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 57 publications over 29 distinct years, with a maximum of 4 publications in 2002 and 2006 and 2007 and 2010

YearPublications
19802
19822
19832
19841
19852
19861
19882
19892
19901
19912
19922
19931
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19971
19981
20001
20012
20024
20033
20042
20051
20064
20074
20081
20093
20104
20111
20121
20132
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Calcium-binding proteins
Lung surfactant proteins
Protein crystallography
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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