Keywords
Last Name

Frank G. Oppenheim, DMD, PhD

TitleEmeritus Professor
InstitutionBoston University Henry M. Goldman School of Dental Medicine
DepartmentMolecular & Cell Biology
Address700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Phone(617) 638-4733
Other Positions
InstitutionBoston Medical Center

 Research Expertise & Professional Interests
The work of my laboratory focuses on the elucidation of structure and function of salivary proteins, which play important role in host defense mechanisms. Structural analysis, peptide biomimetics employing solid phase peptide synthesis and recombinant expression methods are being used in the identification of functional domains within proteins. Functional investigations comprise mechanisms related to anti-bacterial, anti-fungal and mineral homeostasis. Emphasis on these processes is aimed at understanding the basic physiology of hard and soft tissue protection in the oral environment. Proteins such as the histatins, the proline-rich proteins and statherin are examples of proteins unique to the oral cavity. For example, the discovery of the histatin protein family showed that these small basic proteins are rich in histidine, exhibit anti-microbial properties, contain specific functional domains, and are able to kill yeasts by entering cells and target mitochondria. The mechanisms of cell death is being studied. and it has been shown that the killing effect of histatins is related to the inhibition of the respiratory chain leading to the formation reactive oxygen radicals. Other studies in progress comprise the identification and characterization of salivary protein which show selective adsorption to hydroxyapaptite forming a unique protein film on the mineral surfaces of teeth. This protein film determines de- and re-mineralization processes and dictates the early events of microbial colonization.. These studies include biophysical techniques such as NMR and mass spectrometry. Approaches of proteomics are being used to characterize proteins and peptides formed on mineral surfaces in vivo.



 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Alevizos I, Zheng C, Cotrim AP, Liu S, McCullagh L, Billings ME, Goldsmith CM, Tandon M, Helmerhorst EJ, Catalán MA, Danielides SJ, Perez P, Nikolov NP, Chiorini JA, Melvin JE, Oppenheim FG, Illei GG, Baum BJ. Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction. Gene Ther. 2017 Jan 19. PMID: 27996967.
    View in: PubMed
  2. Heller D, Helmerhorst EJ, Oppenheim FG. Saliva and Serum Protein Exchange at the Tooth Enamel Surface. J Dent Res. 2017 Apr; 96(4):437-443. PMID: 27879420.
    View in: PubMed
  3. Heller D, Helmerhorst EJ, Gower AC, Siqueira WL, Paster BJ, Oppenheim FG. Microbial Diversity in the Early In Vivo-Formed Dental Biofilm. Appl Environ Microbiol. 2016 Jan 08; 82(6):1881-8. PMID: 26746720.
    View in: PubMed
  4. Nie S, Zhang H, Mayer KM, Oppenheim FG, Little FF, Greenberg J, Uluer AZ, Walt DR. Correlations of salivary biomarkers with clinical assessments in patients with cystic fibrosis. PLoS One. 2015; 10(8):e0135237. PMID: 26258476.
    View in: PubMed
  5. Trindade F, Oppenheim FG, Helmerhorst EJ, Amado F, Gomes PS, Vitorino R. Uncovering the molecular networks in periodontitis. Proteomics Clin Appl. 2014 Oct; 8(9-10):748-61. PMID: 24828325.
    View in: PubMed
  6. Iavarone F, D'Alessandro A, Tian N, Cabras T, Messana I, Helmerhorst EJ, Oppenheim FG, Castagnola M. High-resolution high-performance liquid chromatography with electrospray ionization mass spectrometry and tandem mass spectrometry characterization of a new isoform of human salivary acidic proline-rich proteins named Roma-Boston Ser22 (Phos) ? Phe variant. J Sep Sci. 2014 Jul; 37(14):1896-902. PMID: 24771659.
    View in: PubMed
  7. Nie S, Henley WH, Miller SE, Zhang H, Mayer KM, Dennis PJ, Oblath EA, Alarie JP, Wu Y, Oppenheim FG, Little FF, Uluer AZ, Wang P, Ramsey JM, Walt DR. An automated integrated platform for rapid and sensitive multiplexed protein profiling using human saliva samples. Lab Chip. 2014 Mar 21; 14(6):1087-98. PMID: 24448498.
    View in: PubMed
  8. Vukosavljevic D, Hutter JL, Helmerhorst EJ, Xiao Y, Custodio W, Zaidan FC, Oppenheim FG, Siqueira WL. Nanoscale adhesion forces between enamel pellicle proteins and hydroxyapatite. J Dent Res. 2014 May; 93(5):514-9. PMID: 24591293.
    View in: PubMed
  9. Little FF, Delgado DM, Wexler PJ, Oppenheim FG, Mitchell P, Feldman JA, Walt DR, Peng RD, Matsui EC. Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma. PLoS One. 2014; 9(1):e84449. PMID: 24409298.
    View in: PubMed
  10. Fernandez-Feo M, Wei G, Blumenkranz G, Dewhirst FE, Schuppan D, Oppenheim FG, Helmerhorst EJ. The cultivable human oral gluten-degrading microbiome and its potential implications in coeliac disease and gluten sensitivity. Clin Microbiol Infect. 2013 Sep; 19(9):E386-94. PMID: 23714165.
    View in: PubMed
  11. Oppenheim FG, Helmerhorst EJ, Lendenmann U, Offner GD. Anti-candidal activity of genetically engineered histatin variants with multiple functional domains. PLoS One. 2012; 7(12):e51479. PMID: 23251551.
    View in: PubMed
  12. Carneiro LG, Venuleo C, Oppenheim FG, Salih E. Proteome data set of human gingival crevicular fluid from healthy periodontium sites by multidimensional protein separation and mass spectrometry. J Periodontal Res. 2012 Apr; 47(2):248-62. PMID: 22029670.
    View in: PubMed
  13. Zamakhchari M, Wei G, Dewhirst F, Lee J, Schuppan D, Oppenheim FG, Helmerhorst EJ. Identification of Rothia bacteria as gluten-degrading natural colonizers of the upper gastro-intestinal tract. PLoS One. 2011; 6(9):e24455. PMID: 21957450.
    View in: PubMed
  14. Thomadaki K, Helmerhorst EJ, Tian N, Sun X, Siqueira WL, Walt DR, Oppenheim FG. Whole-saliva proteolysis and its impact on salivary diagnostics. J Dent Res. 2011 Nov; 90(11):1325-30. PMID: 21917601.
    View in: PubMed
  15. Price AM, Nunn M, Oppenheim FG, Van Dyke TE. De novo bone formation after the sinus lift procedure. J Periodontol. 2011 Sep; 82(9):1245-55. PMID: 21235336.
    View in: PubMed
  16. Komatsu T, Salih E, Helmerhorst EJ, Offner GD, Oppenheim FG. Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry. J Proteome Res. 2011 Feb 4; 10(2):646-55. PMID: 21080726.
    View in: PubMed
  17. Helmerhorst EJ, Zamakhchari M, Schuppan D, Oppenheim FG. Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity. PLoS One. 2010; 5(10):e13264. PMID: 20948997.
    View in: PubMed
  18. Helmerhorst EJ, Traboulsi G, Salih E, Oppenheim FG. Mass spectrometric identification of key proteolytic cleavage sites in statherin affecting mineral homeostasis and bacterial binding domains. J Proteome Res. 2010 Oct 1; 9(10):5413-21. PMID: 20731414.
    View in: PubMed
  19. Hanasab H, Jammal D, Oppenheim FG, Helmerhorst EJ. The antifungal activity of human parotid secretion is species-specific. Med Mycol. 2011 Feb; 49(2):218-21. PMID: 20807025.
    View in: PubMed
  20. Salih E, Siqueira WL, Helmerhorst EJ, Oppenheim FG. Large-scale phosphoproteome of human whole saliva using disulfide-thiol interchange covalent chromatography and mass spectrometry. Anal Biochem. 2010 Dec 1; 407(1):19-33. PMID: 20659418.
    View in: PubMed
  21. Siqueira WL, Margolis HC, Helmerhorst EJ, Mendes FM, Oppenheim FG. Evidence of intact histatins in the in vivo acquired enamel pellicle. J Dent Res. 2010 Jun; 89(6):626-30. PMID: 20351356.
    View in: PubMed
  22. Curtin P, McHugh KP, Zhou HY, Flückiger R, Goldhaber P, Oppenheim FG, Salih E. Modulation of bone resorption by phosphorylation state of bone sialoprotein. Biochemistry. 2009 Jul 28; 48(29):6876-86. PMID: 19518132.
    View in: PubMed
  23. Sun X, Salih E, Oppenheim FG, Helmerhorst EJ. Activity-based mass spectrometric characterization of proteases and inhibitors in human saliva. Proteomics Clin Appl. 2009 Jul 01; 3(7):810-820. PMID: 20011683.
    View in: PubMed
  24. Sun X, Salih E, Oppenheim FG, Helmerhorst EJ. Kinetics of histatin proteolysis in whole saliva and the effect on bioactive domains with metal-binding, antifungal, and wound-healing properties. FASEB J. 2009 Aug; 23(8):2691-701. PMID: 19339663.
    View in: PubMed
  25. Blicharz TM, Siqueira WL, Helmerhorst EJ, Oppenheim FG, Wexler PJ, Little FF, Walt DR. Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva. Anal Chem. 2009 Mar 15; 81(6):2106-14. PMID: 19192965.
    View in: PubMed
  26. Siqueira WL, Oppenheim FG. Small molecular weight proteins/peptides present in the in vivo formed human acquired enamel pellicle. Arch Oral Biol. 2009 May; 54(5):437-44. PMID: 19268279.
    View in: PubMed
  27. White MR, Helmerhorst EJ, Ligtenberg A, Karpel M, Tecle T, Siqueira WL, Oppenheim FG, Hartshorn KL. Multiple components contribute to ability of saliva to inhibit influenza viruses. Oral Microbiol Immunol. 2009 Feb; 24(1):18-24. PMID: 19121065.
    View in: PubMed
  28. Campese M, Sun X, Bosch JA, Oppenheim FG, Helmerhorst EJ. Concentration and fate of histatins and acidic proline-rich proteins in the oral environment. Arch Oral Biol. 2009 Apr; 54(4):345-53. PMID: 19159863.
    View in: PubMed
  29. Blicharz TM, Rissin DM, Bowden M, Hayman RB, DiCesare C, Bhatia JS, Grand-Pierre N, Siqueira WL, Helmerhorst EJ, Loscalzo J, Oppenheim FG, Walt DR. Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: a proof of principle. Clin Chem. 2008 Sep; 54(9):1473-80. PMID: 18676588.
    View in: PubMed
  30. Helmerhorst EJ, Sun X, Salih E, Oppenheim FG. Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases. J Biol Chem. 2008 Jul 18; 283(29):19957-66. PMID: 18463091.
    View in: PubMed
  31. Siqueira WL, Salih E, Wan DL, Helmerhorst EJ, Oppenheim FG. Proteome of human minor salivary gland secretion. J Dent Res. 2008 May; 87(5):445-50. PMID: 18434574.
    View in: PubMed
  32. Elangovan S, Margolis HC, Oppenheim FG, Beniash E. Conformational changes in salivary proline-rich protein 1 upon adsorption to calcium phosphate crystals. Langmuir. 2007 Oct 23; 23(22):11200-5. PMID: 17880251.
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  33. Helmerhorst EJ, Oppenheim FG. Saliva: a dynamic proteome. J Dent Res. 2007 Aug; 86(8):680-93. PMID: 17652194.
    View in: PubMed
  34. Siqueira WL, Zhang W, Helmerhorst EJ, Gygi SP, Oppenheim FG. Identification of protein components in in vivo human acquired enamel pellicle using LC-ESI-MS/MS. J Proteome Res. 2007 Jun; 6(6):2152-60. PMID: 17447804.
    View in: PubMed
  35. Walt DR, Blicharz TM, Hayman RB, Rissin DM, Bowden M, Siqueira WL, Helmerhorst EJ, Grand-Pierre N, Oppenheim FG, Bhatia JS, Little FF, Brody JS. Microsensor arrays for saliva diagnostics. Ann N Y Acad Sci. 2007 Mar; 1098:389-400. PMID: 17435144.
    View in: PubMed
  36. Siqueira WL, Helmerhorst EJ, Zhang W, Salih E, Oppenheim FG. Acquired enamel pellicle and its potential role in oral diagnostics. Ann N Y Acad Sci. 2007 Mar; 1098:504-9. PMID: 17435160.
    View in: PubMed
  37. Oppenheim FG, Salih E, Siqueira WL, Zhang W, Helmerhorst EJ. Salivary proteome and its genetic polymorphisms. Ann N Y Acad Sci. 2007 Mar; 1098:22-50. PMID: 17303824.
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  38. Helmerhorst EJ, Alagl AS, Siqueira WL, Oppenheim FG. Oral fluid proteolytic effects on histatin 5 structure and function. Arch Oral Biol. 2006 Dec; 51(12):1061-70. PMID: 16901460.
    View in: PubMed
  39. Piludu M, Lantini MS, Cossu M, Piras M, Oppenheim FG, Helmerhorst EJ, Siqueira W, Hand AR. Salivary histatins in human deep posterior lingual glands (of von Ebner). Arch Oral Biol. 2006 Nov; 51(11):967-73. PMID: 16859632.
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  40. Helmerhorst EJ, Venuleo C, Sanglard D, Oppenheim FG. Roles of cellular respiration, CgCDR1, and CgCDR2 in Candida glabrata resistance to histatin 5. Antimicrob Agents Chemother. 2006 Mar; 50(3):1100-3. PMID: 16495279.
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  41. Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD. Two-hybrid analysis of human salivary mucin MUC7 interactions. Biochim Biophys Acta. 2005 Oct 30; 1746(1):65-72. PMID: 16203048.
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  42. Yin A, Margolis HC, Yao Y, Grogan J, Oppenheim FG. Multi-component adsorption model for pellicle formation: the influence of salivary proteins and non-salivary phospho proteins on the binding of histatin 5 onto hydroxyapatite. Arch Oral Biol. 2006 Feb; 51(2):102-10. PMID: 16055080.
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  43. Helmerhorst EJ, Venuleo C, Beri A, Oppenheim FG. Candida glabrata is unusual with respect to its resistance to cationic antifungal proteins. Yeast. 2005 Jul 15; 22(9):705-14. PMID: 16034806.
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  44. Helmerhorst EJ, Stan M, Murphy MP, Sherman F, Oppenheim FG. The concomitant expression and availability of conventional and alternative, cyanide-insensitive, respiratory pathways in Candida albicans. Mitochondrion. 2005 Jun; 5(3):200-11. PMID: 16050985.
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  45. Liu Z, Kim J, Sypek JP, Wang IM, Horton H, Oppenheim FG, Bochner BS. Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray. J Allergy Clin Immunol. 2004 Oct; 114(4):783-90. PMID: 15480316.
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  46. Li J, Helmerhorst EJ, Yao Y, Nunn ME, Troxler RF, Oppenheim FG. Statherin is an in vivo pellicle constituent: identification and immuno-quantification. Arch Oral Biol. 2004 May; 49(5):379-85. PMID: 15041485.
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  47. Helmerhorst EJ, Flora B, Troxler RF, Oppenheim FG. Dialysis unmasks the fungicidal properties of glandular salivary secretions. Infect Immun. 2004 May; 72(5):2703-9. PMID: 15102779.
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  48. Soares RV, Lin T, Siqueira CC, Bruno LS, Li X, Oppenheim FG, Offner G, Troxler RF. Salivary micelles: identification of complexes containing MG2, sIgA, lactoferrin, amylase, glycosylated proline-rich protein and lysozyme. Arch Oral Biol. 2004 May; 49(5):337-43. PMID: 15041480.
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  49. Ahmad M, Piludu M, Oppenheim FG, Helmerhorst EJ, Hand AR. Immunocytochemical localization of histatins in human salivary glands. J Histochem Cytochem. 2004 Mar; 52(3):361-70. PMID: 14966203.
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  50. Li J, Helmerhorst EJ, Troxler RF, Oppenheim FG. Identification of in vivo pellicle constituents by analysis of serum immune responses. J Dent Res. 2004 Jan; 83(1):60-4. PMID: 14691115.
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  51. Li J, Helmerhorst EJ, Leone CW, Troxler RF, Yaskell T, Haffajee AD, Socransky SS, Oppenheim FG. Identification of early microbial colonizers in human dental biofilm. J Appl Microbiol. 2004; 97(6):1311-8. PMID: 15546422.
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  52. Gusman H, Leone C, Helmerhorst EJ, Nunn M, Flora B, Troxler RF, Oppenheim FG. Human salivary gland-specific daily variations in histatin concentrations determined by a novel quantitation technique. Arch Oral Biol. 2004 Jan; 49(1):11-22. PMID: 14693192.
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  53. Soares RV, Siqueira CC, Bruno LS, Oppenheim FG, Offner GD, Troxler RF. MG2 and lactoferrin form a heterotypic complex in salivary secretions. J Dent Res. 2003 Jun; 82(6):471-5. PMID: 12766201.
    View in: PubMed
  54. Li J, Helmerhorst EJ, Corley RB, Luus LE, Troxler RF, Oppenheim FG. Characterization of the immunologic responses to human in vivo acquired enamel pellicle as a novel means to investigate its composition. Oral Microbiol Immunol. 2003 Jun; 18(3):183-91. PMID: 12753471.
    View in: PubMed
  55. Yin A, Margolis HC, Grogan J, Yao Y, Troxler RF, Oppenheim FG. Physical parameters of hydroxyapatite adsorption and effect on candidacidal activity of histatins. Arch Oral Biol. 2003 May; 48(5):361-8. PMID: 12711380.
    View in: PubMed
  56. Becerra L, Soares RV, Bruno LS, Siqueira CC, Oppenheim FG, Offner GD, Troxler RF. Patterns of secretion of mucins and non-mucin glycoproteins in human submandibular/sublingual secretion. Arch Oral Biol. 2003 Feb; 48(2):147-54. PMID: 12642234.
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  57. Piludu M, Rayment SA, Liu B, Offner GD, Oppenheim FG, Troxler RF, Hand AR. Electron microscopic immunogold localization of salivary mucins MG1 and MG2 in human submandibular and sublingual glands. J Histochem Cytochem. 2003 Jan; 51(1):69-79. PMID: 12502756.
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  58. Liu B, Rayment SA, Soares RV, Oppenheim FG, Offner GD, Fives-Taylor P, Troxler RF. Interaction of human salivary mucin MG2, its recombinant N-terminal region and a synthetic peptide with Actinobacillus actinomycetemcomitans. J Periodontal Res. 2002 Dec; 37(6):416-24. PMID: 12472835.
    View in: PubMed
  59. Yao Y, Berg EA, Costello CE, Troxler RF, Oppenheim FG. Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches. J Biol Chem. 2003 Feb 14; 278(7):5300-8. PMID: 12444093.
    View in: PubMed
  60. Helmerhorst EJ, Murphy MP, Troxler RF, Oppenheim FG. Characterization of the mitochondrial respiratory pathways in Candida albicans. Biochim Biophys Acta. 2002 Oct 3; 1556(1):73-80. PMID: 12351220.
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  61. Leymarie N, Berg EA, McComb ME, O'Connor PB, Grogan J, Oppenheim FG, Costello CE. Tandem mass spectrometry for structural characterization of proline-rich proteins: application to salivary PRP-3. Anal Chem. 2002 Aug 15; 74(16):4124-32. PMID: 12199583.
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  62. Soares RV, Liu B, Oppenheim FG, Offner GD, Troxler RF. Structural characterisation of cysteines in a bacterial-binding motif of human salivary mucin MG2. Arch Oral Biol. 2002 Aug; 47(8):591-7. PMID: 12221016.
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  63. Liu B, Lague JR, Nunes DP, Toselli P, Oppenheim FG, Soares RV, Troxler RF, Offner GD. Expression of membrane-associated mucins MUC1 and MUC4 in major human salivary glands. J Histochem Cytochem. 2002 Jun; 50(6):811-20. PMID: 12019297.
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  64. Murakami Y, Xu T, Helmerhorst EJ, Ori G, Troxler RF, Lally ET, Oppenheim FG. Inhibitory effect of synthetic histatin 5 on leukotoxin from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2002 Jun; 17(3):143-9. PMID: 12030965.
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  65. Rothstein DM, Helmerhorst EJ, Spacciapoli P, Oppenheim FG, Friden P. Histatin-derived peptides: potential agents to treat localised infections. Expert Opin Emerg Drugs. 2002 May; 7(1):47-59. PMID: 15989535.
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  66. Murakami Y, Higuchi N, Nakamura H, Yoshimura F, Oppenheim FG. Bacteroides forsythus hemagglutinin is inhibited by N-acetylneuraminyllactose. Oral Microbiol Immunol. 2002 Apr; 17(2):125-8. PMID: 11929561.
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  67. Helmerhorst EJ, Troxler RF, Oppenheim FG. The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species. Proc Natl Acad Sci U S A. 2001 Dec 4; 98(25):14637-42. PMID: 11717389.
    View in: PubMed
  68. Flora B, Gusman H, Helmerhorst EJ, Troxler RF, Oppenheim FG. A new method for the isolation of histatins 1, 3, and 5 from parotid secretion using zinc precipitation. Protein Expr Purif. 2001 Oct; 23(1):198-206. PMID: 11570863.
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  69. Leone CW, Oppenheim FG. Physical and chemical aspects of saliva as indicators of risk for dental caries in humans. J Dent Educ. 2001 Oct; 65(10):1054-62. PMID: 11699977.
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  70. Gyurko C, Lendenmann U, Helmerhorst EJ, Troxler RF, Oppenheim FG. Killing of Candida albicans by histatin 5: cellular uptake and energy requirement. Antonie Van Leeuwenhoek. 2001 Sep; 79(3-4):297-309. PMID: 11816973.
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  71. Rayment SA, Liu B, Soares RV, Offner GD, Oppenheim FG, Troxler RF. The effects of duration and intensity of stimulation on total protein and mucin concentrations in resting and stimulated whole saliva. J Dent Res. 2001 Jun; 80(6):1584-7. PMID: 11499518.
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  72. Rothstein DM, Spacciapoli P, Tran LT, Xu T, Roberts FD, Dalla Serra M, Buxton DK, Oppenheim FG, Friden P. Anticandida activity is retained in P-113, a 12-amino-acid fragment of histatin 5. Antimicrob Agents Chemother. 2001 May; 45(5):1367-73. PMID: 11302797.
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  73. Mickels N, McManus C, Massaro J, Friden P, Braman V, D'Agostino R, Oppenheim F, Warbington M, Dibart S, Van Dyke T. Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis. J Clin Periodontol. 2001 May; 28(5):404-10. PMID: 11350502.
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  74. Yao Y, Grogan J, Zehnder M, Lendenmann U, Nam B, Wu Z, Costello CE, Oppenheim FG. Compositional analysis of human acquired enamel pellicle by mass spectrometry. Arch Oral Biol. 2001 Apr; 46(4):293-303. PMID: 11269863.
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  75. Robinovitch MR, Ashley RL, Iversen JM, Vigoren EM, Oppenheim FG, Lamkin M. Parotid salivary basic proline-rich proteins inhibit HIV-I infectivity. Oral Dis. 2001 Mar; 7(2):86-93. PMID: 11355444.
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  76. Gusman H, Travis J, Helmerhorst EJ, Potempa J, Troxler RF, Oppenheim FG. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease. Infect Immun. 2001 Mar; 69(3):1402-8. PMID: 11179305.
    View in: PubMed
  77. Grogan J, McKnight CJ, Troxler RF, Oppenheim FG. Zinc and copper bind to unique sites of histatin 5. FEBS Lett. 2001 Feb 23; 491(1-2):76-80. PMID: 11226423.
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  78. Gusman H, Lendenmann U, Grogan J, Troxler RF, Oppenheim FG. Is salivary histatin 5 a metallopeptide? Biochim Biophys Acta. 2001 Feb 9; 1545(1-2):86-95. PMID: 11342034.
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  79. Schüpbach P, Oppenheim FG, Lendenmann U, Lamkin MS, Yao Y, Guggenheim B. Electron-microscopic demonstration of proline-rich proteins, statherin, and histatins in acquired enamel pellicles in vitro. Eur J Oral Sci. 2001 Feb; 109(1):60-8. PMID: 11330936.
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  80. Gusman H, Grogan J, Kagan HM, Troxler RF, Oppenheim FG. Salivary histatin 5 is a potent competitive inhibitor of the cysteine proteinase clostripain. FEBS Lett. 2001 Jan 26; 489(1):97-100. PMID: 11231021.
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  81. Lamkin MS, Migliari D, Yao Y, Troxler RF, Oppenheim FG. New in vitro model for the acquired enamel pellicle: pellicles formed from whole saliva show inter-subject consistency in protein composition and proteolytic fragmentation patterns. J Dent Res. 2001 Jan; 80(1):385-8. PMID: 11269733.
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  82. Lendenmann U, Grogan J, Oppenheim FG. Saliva and dental pellicle--a review. Adv Dent Res. 2000 Dec; 14:22-8. PMID: 11842920.
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  83. Helmerhorst EJ, van't Hof W, Breeuwer P, Veerman EC, Abee T, Troxler RF, Amerongen AV, Oppenheim FG. Characterization of histatin 5 with respect to amphipathicity, hydrophobicity, and effects on cell and mitochondrial membrane integrity excludes a candidacidal mechanism of pore formation. J Biol Chem. 2001 Feb 23; 276(8):5643-9. PMID: 11099499.
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  84. Rayment SA, Liu B, Offner GD, Oppenheim FG, Troxler RF. Salivary mucin: a factor in the lower prevalence of gastroesophageal reflux disease in African-Americans? Am J Gastroenterol. 2000 Nov; 95(11):3064-70. PMID: 11095319.
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  85. Rayment SA, Liu B, Offner GD, Oppenheim FG, Troxler RF. Immunoquantification of human salivary mucins MG1 and MG2 in stimulated whole saliva: factors influencing mucin levels. J Dent Res. 2000 Oct; 79(10):1765-72. PMID: 11077992.
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  86. Yao Y, Lamkin MS, Oppenheim FG. Pellicle precursor protein crosslinking characterization of an adduct between acidic proline-rich protein (PRP-1) and statherin generated by transglutaminase. J Dent Res. 2000 Apr; 79(4):930-8. PMID: 10831095.
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  87. Gyurko C, Lendenmann U, Troxler RF, Oppenheim FG. Candida albicans mutants deficient in respiration are resistant to the small cationic salivary antimicrobial peptide histatin 5. Antimicrob Agents Chemother. 2000 Feb; 44(2):348-54. PMID: 10639361.
    View in: PubMed
  88. Liu B, Rayment SA, Gyurko C, Oppenheim FG, Offner GD, Troxler RF. The recombinant N-terminal region of human salivary mucin MG2 (MUC7) contains a binding domain for oral Streptococci and exhibits candidacidal activity. Biochem J. 2000 Feb 1; 345 Pt 3:557-64. PMID: 10642514.
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  89. Iontcheva I, Oppenheim FG, Offner GD, Troxler RF. Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system. J Dent Res. 2000 Feb; 79(2):732-9. PMID: 10728974.
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  90. Yao Y, Lamkin MS, Oppenheim FG. Pellicle precursor proteins: acidic proline-rich proteins, statherin, and histatins, and their crosslinking reaction by oral transglutaminase. J Dent Res. 1999 Nov; 78(11):1696-703. PMID: 10576165.
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  91. Liu B, Rayment S, Oppenheim FG, Troxler RF. Isolation of human salivary mucin MG2 by a novel method and characterization of its interactions with oral bacteria. Arch Biochem Biophys. 1999 Apr 15; 364(2):286-93. PMID: 10190986.
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  92. Bercier JG, Al-Hashimi I, Haghighat N, Rees TD, Oppenheim FG. Salivary histatins in patients with recurrent oral candidiasis. J Oral Pathol Med. 1999 Jan; 28(1):26-9. PMID: 9890454.
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  98. Iontcheva I, Oppenheim FG, Troxler RF. Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins. J Dent Res. 1997 Mar; 76(3):734-43. PMID: 9109822.
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  99. O'Connell BC, Xu T, Walsh TJ, Sein T, Mastrangeli A, Crystal RG, Oppenheim FG, Baum BJ. Transfer of a gene encoding the anticandidal protein histatin 3 to salivary glands. Hum Gene Ther. 1996 Dec 1; 7(18):2255-61. PMID: 8953316.
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  101. Lamkin MS, Arancillo AA, Oppenheim FG. Temporal and compositional characteristics of salivary protein adsorption to hydroxyapatite. J Dent Res. 1996 Feb; 75(2):803-8. PMID: 8655778.
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  102. Troxler RF, Offner GD, Zhang F, Iontcheva I, Oppenheim FG. Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland. Biochem Biophys Res Commun. 1995 Dec 26; 217(3):1112-9. PMID: 8554565.
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  103. Driscoll J, Zuo Y, Xu T, Choi JR, Troxler RF, Oppenheim FG. Functional comparison of native and recombinant human salivary histatin 1. J Dent Res. 1995 Dec; 74(12):1837-44. PMID: 8600179.
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  104. Zuo Y, Xu T, Troxler RF, Li J, Driscoll J, Oppenheim FG. Recombinant histatins: functional domain duplication enhances candidacidal activity. Gene. 1995 Aug 8; 161(1):87-91. PMID: 7642143.
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  105. Jensen JL, Xu T, Lamkin MS, Brodin P, Aars H, Berg T, Oppenheim FG. Physiological regulation of the secretion of histatins and statherins in human parotid saliva. J Dent Res. 1994 Dec; 73(12):1811-7. PMID: 7814752.
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  106. Kukuruzinska MA, Apekin V, Lamkin MS, Hiltz A, Rodriguez A, Lin CC, Paz MA, Oppenheim FG. Antisense RNA to the first N-glycosylation gene, ALG7, inhibits protein N-glycosylation and secretion by Xenopus oocytes. Biochem Biophys Res Commun. 1994 Feb 15; 198(3):1248-54. PMID: 7509600.
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  107. Fedele DJ, Jones JA, Volicer L, Herz LR, Oppenheim FG. Effects of medication on parotid salivary flow rates in an individual with dementia of the Alzheimer type. Spec Care Dentist. 1993 Sep-Oct; 13(5):215-8. PMID: 7716695.
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  108. Lamkin MS, Oppenheim FG. Structural features of salivary function. Crit Rev Oral Biol Med. 1993; 4(3-4):251-9. PMID: 8373982.
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  109. Xu T and Oppenheim FG. Salivary antimicrobials: Where are we? Cariology for the nineties. Eds. Bowen and Tabak, University of Rochester Press. 1993; 117-131.
  110. Takano K, Malamud D, Bennick A, Oppenheim F, Hand AR. Localization of salivary proteins in granules of human parotid and submandibular acinar cells. Crit Rev Oral Biol Med. 1993; 4(3-4):399-405. PMID: 7690602.
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  111. Oppenheim FG and Xu T. Anticandidal activities of salivary secretions. Proceedings of the second international workshop on the oral manifestations of HIV infection. Quintessence Publishers, Carol Stream, IL. 1993.
  112. Jensen JL, Lamkin MS, Oppenheim FG. Adsorption of human salivary proteins to hydroxyapatite: a comparison between whole saliva and glandular salivary secretions. J Dent Res. 1992 Sep; 71(9):1569-76. PMID: 1381733.
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  113. Lamkin MS, Jensen JL, Setayesh MR, Troxler RF, Oppenheim FG. Salivary cystatin SA-III, a potential precursor of the acquired enamel pellicle, is phosphorylated at both its amino- and carboxyl-terminal regions. Arch Biochem Biophys. 1991 Aug 1; 288(2):664-70. PMID: 1898055.
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  114. Xu T, Levitz SM, Diamond RD, Oppenheim FG. Anticandidal activity of major human salivary histatins. Infect Immun. 1991 Aug; 59(8):2549-54. PMID: 1855975.
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  115. Apekin V, Goldberger G, Oppenheim FG, Paz MA. Biosynthesis and secretion of rat salivary proteins by Xenopus laevis oocytes. J Dent Res. 1991 Feb; 70(2):95-8. PMID: 1991875.
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  116. Jensen JL, Lamkin MS, Troxler RF, Oppenheim FG. Multiple forms of statherin in human salivary secretions. Arch Oral Biol. 1991; 36(7):529-34. PMID: 1663737.
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  117. Xu T, Telser E, Troxler RF, Oppenheim FG. Primary structure and anticandidal activity of the major histatin from parotid secretion of the subhuman primate, Macaca fascicularis. J Dent Res. 1990 Nov; 69(11):1717-23. PMID: 2229609.
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  119. Atkinson JC, Yeh C, Oppenheim FG, Bermudez D, Baum BJ, Fox PC. Elevation of salivary antimicrobial proteins following HIV-1 infection. J Acquir Immune Defic Syndr. 1990; 3(1):41-8. PMID: 2293641.
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  121. vanderSpek JC, Wyandt HE, Skare JC, Milunsky A, Oppenheim FG, Troxler RF. Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs. Am J Hum Genet. 1989 Sep; 45(3):381-7. PMID: 2773933.
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  122. Oppenheim FG, Xu T, McMillian FM, Levitz SM, Diamond RD, Offner GD, Troxler RF. Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans. J Biol Chem. 1988 Jun 5; 263(16):7472-7. PMID: 3286634.
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  123. Oppenheim FG, Hay DI, Smith DJ, Offner GD, Troxler RF. Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides. J Dent Res. 1987 Feb; 66(2):462-6. PMID: 3476566.
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  124. Oppenheim FG, Yang YC, Diamond RD, Hyslop D, Offner GD, Troxler RF. The primary structure and functional characterization of the neutral histidine-rich polypeptide from human parotid secretion. J Biol Chem. 1986 Jan 25; 261(3):1177-82. PMID: 3944083.
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  125. Oppenheim FG, Offner GD, Troxler RF. Amino acid sequence of a proline-rich phosphoglycoprotein from parotid secretion of the subhuman primate Macaca fascicularis. J Biol Chem. 1985 Sep 5; 260(19):10671-9. PMID: 4030765.
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  126. Belford HS, Triffleman EG, Offner GD, Troxler RF, Oppenheim FG. Biosynthesis of salivary proteins in the parotid gland of the subhuman primate, Macaca fascicularis. Cell-free translation of the mRNA for a proline-rich glycoprotein and partial amino acid sequence and processing of its signal peptide. J Biol Chem. 1984 Mar 25; 259(6):3977-84. PMID: 6200480.
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  128. Imberman M, Oppenheim F, Franzblau C. The appearance of free hydroxyproline as the major product of degradation of newly synthesized collagen in cell culture. Biochim Biophys Acta. 1982 Dec 17; 719(3):480-7. PMID: 7150655.
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  130. Baum BJ, Kousvelari EE, Oppenheim FG. Exocrine protein secretion from human parotid glands during aging: stable release of the acidic proline-rich proteins. J Gerontol. 1982 Jul; 37(4):392-5. PMID: 7086073.
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  131. Kousvelari EE, Oppenheim FG, Cutler LS. Ultrastructural localization of salivary acidic proline-rich proteins from Macaca fascicularis. J Histochem Cytochem. 1982 Mar; 30(3):274-8. PMID: 7037943.
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  132. Diamond RD, Oppenheim F, Nakagawa Y, Krzesicki R, Haudenschild CC. Properties of a product of Candida albicans hyphae and pseudohyphae that inhibits contact between the fungi and human neutrophils in vitro. J Immunol. 1980 Dec; 125(6):2797-804. PMID: 7000907.
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  133. Kousvelari EE, Baratz RS, Burke B, Oppenheim FG. Immunochemical identification and determination of proline-rich proteins in salivary secretions, enamel pellicle, and glandular tissue specimens. J Dent Res. 1980 Aug; 59(8):1430-8. PMID: 6772700.
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  134. Cowman RA, Schaefer SJ, Oppenheim FP, Hay DI. Statherin and the proline-rich parotid proteins PRP II and PRP IV as amino nitrogen sources for plaque-forming oral streptococci. J Dent Res. 1979 Oct; 58(10):2008-9. PMID: 291627.
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  135. Kousvelari EE, Oppenheim FG. Immunological comparison of proline-rich proteins from human and primate parotid secretion. Biochim Biophys Acta. 1979 May 23; 578(1):76-86. PMID: 110358.
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  136. Oppenheim FG, Kousvelari E, Troxler R. Immunological cross-reactivity and sequence homology between salivary proline-rich proteins in human and macque monkey (Macaca fascicularis) parotid saliva. Arch Oral Biol. 1979; 24(8):595-9. PMID: 120171.
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  137. Diamond DR, Krzesicki R, Nakagawa Y and Oppenheim FG. Characterization of a product of candida albicans hyphae which inhibits contact between hyphae and neutrophils. Proc VII Congr Intl Soc Human Animal Mycology. Elsevier/N. Holland, Amsterdam. 1979; 223-236.
  138. Oppenheim FG, Kousvelari E and Troxler RF. Genetic, immunological and structural relationships of anionic proline-rich proteins from salivary secretions. Proceedings "Saliva and Dental Caries." Eds. Kleinberg, I., Ellison, S.A. and Mandel, I.D. Sp Supp Microbiology. 1979; 31-44.
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  140. Hay DI, Oppenheim FG. The isolation from human parotid saliva of a further group of proline-rich proteins. Arch Oral Biol. 1974 Aug; 19(8):627-32. PMID: 4532489.
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  141. Lees S, Gerhard FB, Oppenheim FG. Ultrasonic measurement of dental enamel demineralization. Ultrasonics. 1973 Nov; 11(6):269-73. PMID: 4749650.
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  142. Azen EA, Oppenheim FG. Genetic polymorphism of proline-rich human salivary proteins. Science. 1973 Jun 8; 180(4090):1067-9. PMID: 4706325.
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  143. Oppenheim FG, Hay DI. Further studies of human serum albumin in oral fluid. Helv Odontol Acta. 1972 Apr; 16(1):22-6. PMID: 4219019.
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  145. Oppenheim FG. Preliminary observations on the presence and origin of serum albumin in human saliva. Helv Odontol Acta. 1970 Apr; 14(1):10-7. PMID: 5438795.
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  146. Oppenheim FG. In vitro studies on re-hardening and remineralization of human dental enamel. University of Zurich. 1967.
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