Ronald B. Corley, Ph.D.
Director
Boston University
Dept of National Emerging Infectious Disease Lab

PhD, Duke University



My research focuses on the relationship between innate and adaptive immunity, and how components of the two discrete systems interact to generate long-lasting protective immune responses. One area of focus has been on the role of IgM antibodies as efficient bridges of innate and adaptive immunity. IgM antibodies serve to concentrate antigens into secondary lymphoid organs, accelerating the production of protective immune responses along with affinity matured antibodies. IgM also contributes to preventing pathogens from initially localizing into vital organs. The innate functions of IgM can be attributed, at least in part, to its ability to concentrate immune complexes in the foci of the spleen, where innate B cells in the marginal zones traffic the complexes to follicular dendritic cells, stromal elements that promote efficient germinal center formation. These functions require native organization around the marginal sinuses for efficient adjuvant effects of IgM.

The laboratory also focuses on the immune consequences of infection with highly pathogenic hemorrhagic fever viruses, including filoviruses. Patients infected with these viruses often fail to make adaptive immune responses and succumb to infection. While this is often attributed to dysfunctional innate immune responses, the nature of the defects in immune responses to these viruses is poorly understood. We are interested in in the very early immune responses to these viruses, in order to map how they affect the ability of infected animals to initiate adaptive immune responses, and identify the components of infection that lead to abnormal cytokine responses that characterize infection with these viruses.

Professor
Boston University School of Medicine
Microbiology


Chair of Microbiology
Boston University School of Medicine
Microbiology


Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences




National Emerging Infectious Diseases Laboratories Operations
06/01/2016 - 05/31/2018 (PI)
NIH/National Institute of Allergy & Infe
2UC7AI095321-03

National Emerging Infectious Diseases Laboratories Operations
06/01/2015 - 05/31/2016 (PI)
NIH/National Institute of Allergy & Infe
5UC7AI095321-02

National Emerging Infectious Diseases Laboratories Operations
06/01/2014 - 05/31/2016 (PI)
NIH/National Institute of Allergy & Infe
5UC7AI095321-02

IgM Polymerization and J Chain Expression
02/01/2000 - 01/31/2006 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5 R01 AI31209 13

Functional Characterization of Genes Involved in V(D)J Recombination and DNA Repair
07/01/1998 - 06/30/2003 (Dept Sponsor)
Leukemia Society of America

Cellular and Molecular Events in B Lymphocyte Activation
05/01/1997 - 02/28/2003 (PI)
NIH/National Cancer Institute
5 R01 CA36642 19




Yr Title Project-Sub Proj Pubs
2016 National Emerging Infectious Diseases Laboratories Operations 2UC7AI095321-03 1
2016 Administrative Core 2UC7AI095321-03-8664 1
2014 National Emerging Infectious Diseases Laboratories Operations 1UC7AI095321-01 1
2013 Immunology Core 3UC7AI070088-05S3-6798 1
2012 Immunology Core 3UC7AI070088-05S2-7838 1
2011 Immunology Core 3UC7AI070088-05S1-7212 1
2004 IGM POLYMERIZATION AND J CHAIN EXPRESSION 5R01AI031209-13 19
2003 IGM POLYMERIZATION AND J CHAIN EXPRESSION 5R01AI031209-12 19
2002 IGM POLYMERIZATION AND J CHAIN EXPRESSION 5R01AI031209-11 19
2001 CELLULAR AND MOLECULAR EVENTS IN B LYMPHOCYTE ACTIVATION 5R01CA036642-19 22
Showing 10 of 30 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Schultz MJ, Isern S, Michael SF, Corley RB, Connor JH, Frydman HM. Variable Inhibition of Zika Virus Replication by Different Wolbachia Strains in Mosquito Cell Cultures. J Virol. 2017 Jul 15; 91(14).View Related Profiles. PMID: 28446677.
  2. Olejnik J, Ryabchikova E, Corley RB, Mühlberger E. Intracellular events and cell fate in filovirus infection. Viruses. 2011 Aug; 3(8):1501-31.View Related Profiles. PMID: 21927676; PMCID: PMC3172725; DOI: 10.3390/v3081501;.
  3. Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol. 2009 Sep 1; 183(5):3109-17.View Related Profiles. PMID: 19648272; PMCID: PMC2860771; DOI: 10.4049/jimmunol.0900399;.
  4. Busconi L, Bauer JW, Tumang JR, Laws A, Perkins-Mesires K, Tabor AS, Lau C, Corley RB, Rothstein TL, Lund FE, Behrens TW, Marshak-Rothstein A. Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9. J Immunol. 2007 Dec 1; 179(11):7397-405.View Related Profiles. PMID: 18025183.
  5. Corley RB, Morehouse EM, Ferguson AR. IgM accelerates affinity maturation. Scand J Immunol. 2005 Jul; 62 Suppl 1:55-61. PMID: 15953185.
  6. Ferguson AR, Corley RB. Accumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-kappaB p50-deficient mice. BMC Immunol. 2005; 6:8. PMID: 15836790; PMCID: PMC1087843.
  7. Doerre S, Mesires KP, Daley KM, McCarty T, Knoetig S, Corley RB. Reductions in I kappa B epsilon and changes in NF-kappa B activity during B lymphocyte differentiation. J Immunol. 2005 Jan 15; 174(2):983-91. PMID: 15634922.
  8. Corley RB. A Guide to Methods in the Biomedical Sciences. Springer Science+Business Media, Inc. New York. 2005.
  9. Youd ME, Luus L, Corley RB. IgM monomers accelerate disease manifestations in autoimmune-prone Fas-deficient mice. J Autoimmun. 2004 Dec; 23(4):333-43. PMID: 15571927.
  10. Ferguson AR, Youd ME, Corley RB. Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells. Int Immunol. 2004 Oct; 16(10):1411-22. PMID: 15326094.
Showing 10 of 97 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 77 publications over 29 distinct years, with a maximum of 6 publications in 1985 and 1992

YearPublications
19804
19813
19824
19833
19844
19856
19862
19873
19883
19892
19903
19914
19926
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19942
19952
19961
19973
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19992
20001
20021
20031
20044
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20071
20091
20111
20171
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

emerging infectious diseases
immunology
microbiology
virology
Contact for Mentoring:

620 Albany St
Boston MA 02118
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