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PhD, University of Pennsylvania
BA, Washington University in St. Louis

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NIH RePORTER Research

Title

Yr	Title	Project-Sub Proj
2024	Radioresistant Innate Immunity in SAVI Tissue-Specific Autoinflammation	5R21AI178978-02
2024	Mechanisms of STING-driven autoinflammation	5R01HL165787-02
2024	Fas Ligand Cleavage regulates ocular homeostasis and glaucoma	5R01EY032762-03
2024	The role of TLRs, Type II IFN and Type III IFN in a Murine Model of Autoinflammation	5R37AI155901-04
2024	Training in the Molecular Basis of Autoimmunity and Autoinflammation	5T32AI132152-07
2023	Radioresistant Innate Immunity in SAVI Tissue-Specific Autoinflammation	1R21AI178978-01
2023	Mechanisms of STING-driven autoinflammation	1R01HL165787-01A1
2023	Fas Ligand Cleavage regulates ocular homeostasis and glaucoma	5R01EY032762-02
2023	Fas Ligand Cleavage regulates ocular homeostasis and glaucoma	3R01EY032762-02S1
2023	The role of TLRs, Type II IFN and Type III IFN in a Murine Model of Autoinflammation	5R37AI155901-03

Showing 10 of 124 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Giles JR, Neves AT, Marshak-Rothstein A, Shlomchik MJ. Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation. JCI Insight. 2017 02 23; 2(4):e90870. PMID: 28239656; DOI: 10.1172/jci.insight.90870;

Baum R, Sharma S, Organ JM, Jakobs C, Hornung V, Burr DB, Marshak-Rothstein A, Fitzgerald KA, Gravallese EM. STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice. Arthritis Rheumatol. 2017 Feb; 69(2):460-471. PMID: 27740718; DOI: 10.1002/art.39863;

Krishnan A, Fei F, Jones A, Busto P, Marshak-Rothstein A, Ksander BR, Gregory-Ksander M. Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma. J Immunol. 2016 Dec 15; 197(12):4626-4638. PMID: 27849168

Pawaria S, Sharma S, Baum R, Nündel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent? J Leukoc Biol. 2017 Jan; 101(1):121-126. PMID: 27531928; DOI: 10.1189/jlb.3MR0316-115R;

Bossaller L, Christ A, Pelka K, Nündel K, Chiang PI, Pang C, Mishra N, Busto P, Bonegio RG, Schmidt RE, Latz E, Marshak-Rothstein A. TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus. J Immunol. 2016 Aug 15; 197(4):1044-53.View Related Profiles.

Marshak-Rothstein, Ann
Bonegio, Ramon

PMID: 27354219; PMCID: PMC5266544; DOI: 10.4049/jimmunol.1501943;

Baum R, Nündel K, Pawaria S, Sharma S, Busto P, Fitzgerald KA, Gravallese EM, Marshak-Rothstein A. Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice. J Immunol. 2016 Feb 1; 196(3):1348-54. PMID: 26729810; PMCID: PMC4724517; DOI: 10.4049/jimmunol.1502130;

Marshak-Rothstein A. Autoimmunity--promoting and stabilizing innate immunity 'UNWUCHT'. Immunol Rev. 2016 Jan; 269(1):7-10. PMID: 26683141; DOI: 10.1111/imr.12387;

Moody KL, Uccellini MB, Avalos AM, Marshak-Rothstein A, Viglianti GA. Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells. Methods Mol Biol. 2016; 1390:249-72.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Moody, Krishna-Sulayman

PMID: 26803634; DOI: 10.1007/978-1-4939-3335-8_16;

Matsumoto H, Murakami Y, Kataoka K, Notomi S, Mantopoulos D, Trichonas G, Miller JW, Gregory MS, Ksander BR, Marshak-Rothstein A, Vavvas DG. Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium. Cell Death Dis. 2015; 6:e1986. PMID: 26583327; PMCID: PMC4670938; DOI: 10.1038/cddis.2015.334;

Brodeur TY, Robidoux TE, Weinstein JS, Craft J, Swain SL, Marshak-Rothstein A. IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells. J Immunol. 2015 Dec 1; 195(11):5251-60. PMID: 26519529; PMCID: PMC4655158; DOI: 10.4049/jimmunol.1500777;

Showing 10 of 155 results. Show More

Sharma S, Fitzgerald KA, Cancro MP, Marshak-Rothstein A. Nucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation. J Immunol. 2015 Oct 15; 195(8):3507-12. PMID: 26432899; PMCID: PMC4593056; DOI: 10.4049/jimmunol.1500964;

Pawaria S, Moody KL, Busto P, Nündel K, Baum R, Sharma S, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S70-3.View Related Profiles.

Marshak-Rothstein, Ann
Moody, Krishna-Sulayman

PMID: 26457825; PMCID: PMC4731237

Nündel K, Green NM, Shaffer AL, Moody KL, Busto P, Eilat D, Miyake K, Oropallo MA, Cancro MP, Marshak-Rothstein A. Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses. J Immunol. 2015 Mar 15; 194(6):2504-12.View Related Profiles.

Marshak-Rothstein, Ann
Moody, Krishna-Sulayman

PMID: 25681333; PMCID: PMC4382804; DOI: 10.4049/jimmunol.1402425;

Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E710-7. PMID: 25646421; PMCID: PMC4343138; DOI: 10.1073/pnas.1420217112;

Pawaria S, Moody K, Busto P, Nündel K, Choi CH, Ghayur T, Marshak-Rothstein A. Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands. J Immunol. 2015 Feb 15; 194(4):1403-7.View Related Profiles.

Marshak-Rothstein, Ann
Moody, Krishna-Sulayman

PMID: 25601924; PMCID: PMC4323726; DOI: 10.4049/jimmunol.1402893;

Baum R, Sharma S, Carpenter S, Li QZ, Busto P, Fitzgerald KA, Marshak-Rothstein A, Gravallese EM. Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice. J Immunol. 2015 Feb 1; 194(3):873-7. PMID: 25548216; PMCID: PMC4299698; DOI: 10.4049/jimmunol.1402573;

Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid-Burgk JL, Schmidt T, Spille JH, Labzin LI, Agrawal S, Kandimalla ER, Casanova JL, Hornung V, Marshak-Rothstein A, Höning S, Latz E. Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms. J Immunol. 2014 Oct 1; 193(7):3257-61. PMID: 25187660; PMCID: PMC4170058; DOI: 10.4049/jimmunol.1301886;

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nat Immunol. 2014 Aug; 15(8):727-37. PMID: 24952505; PMCID: PMC4116676; DOI: 10.1038/ni.2913;

Schmidt-Lauber C, Bossaller L, Abujudeh HH, Vladimer GI, Christ A, Fitzgerald KA, Latz E, Gravallese EM, Marshak-Rothstein A, Kay J. Gadolinium-based compounds induce NLRP3-dependent IL-1ß production and peritoneal inflammation. Ann Rheum Dis. 2015 Nov; 74(11):2062-9. PMID: 24914072; PMCID: PMC4428954; DOI: 10.1136/annrheumdis-2013-204900;

Gratz IK, Rosenblum MD, Maurano MM, Paw JS, Truong HA, Marshak-Rothstein A, Abbas AK. Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues. J Immunol. 2014 Feb 15; 192(4):1351-5. PMID: 24442443; PMCID: PMC3925257; DOI: 10.4049/jimmunol.1301777;

Lehuen A, Marshak-Rothstein A. Organ-specific and systemic autoimmune diseases. Curr Opin Immunol. 2013 Dec; 25(6):667-9. PMID: 24246387; DOI: 10.1016/j.coi.2013.10.014;

Bossaller L, Rathinam VA, Bonegio R, Chiang PI, Busto P, Wespiser AR, Caffrey DR, Li QZ, Mohan C, Fitzgerald KA, Latz E, Marshak-Rothstein A. Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus. J Immunol. 2013 Sep 1; 191(5):2104-14.View Related Profiles.

Marshak-Rothstein, Ann
Bonegio, Ramon

PMID: 23918976; PMCID: PMC4219920; DOI: 10.4049/jimmunol.1300341;

Nündel K, Busto P, Debatis M, Marshak-Rothstein A. The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells. J Leukoc Biol. 2013 Nov; 94(5):865-75. PMID: 23804807; PMCID: PMC3800065; DOI: 10.1189/jlb.0313126;

Yasuda K, Nündel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR. Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int Immunol. 2013 May; 25(5):295-306.View Related Profiles.

Watkins, Amanda
Marshak-Rothstein, Ann
Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon

PMID: 23291967; PMCID: PMC3631000; DOI: 10.1093/intimm/dxs114;

Bossaller L, Chiang PI, Schmidt-Lauber C, Ganesan S, Kaiser WJ, Rathinam VA, Mocarski ES, Subramanian D, Green DR, Silverman N, Fitzgerald KA, Marshak-Rothstein A, Latz E. Cutting edge: FAS (CD95) mediates noncanonical IL-1ß and IL-18 maturation via caspase-8 in an RIP3-independent manner. J Immunol. 2012 Dec 15; 189(12):5508-12. PMID: 23144495; PMCID: PMC3518757; DOI: 10.4049/jimmunol.1202121;

Vas J, Grönwall C, Marshak-Rothstein A, Silverman GJ. Natural antibody to apoptotic cell membranes inhibits the proinflammatory properties of lupus autoantibody immune complexes. Arthritis Rheum. 2012 Oct; 64(10):3388-98. PMID: 22577035; PMCID: PMC3462267; DOI: 10.1002/art.34537;

Green NM, Moody KS, Debatis M, Marshak-Rothstein A. Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands. J Biol Chem. 2012 Nov 16; 287(47):39789-99.View Related Profiles.

Marshak-Rothstein, Ann
Moody, Krishna-Sulayman

PMID: 23019335; PMCID: PMC3501070; DOI: 10.1074/jbc.M112.383000;

Kiefer K, Oropallo MA, Cancro MP, Marshak-Rothstein A. Role of type I interferons in the activation of autoreactive B cells. Immunol Cell Biol. 2012 May; 90(5):498-504. PMID: 22430248; PMCID: PMC3701256; DOI: 10.1038/icb.2012.10;

Han H, Xu W, Headley MB, Jessup HK, Lee KS, Omori M, Comeau MR, Marshak-Rothstein A, Ziegler SF. Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma. Mucosal Immunol. 2012 May; 5(3):342-51. PMID: 22354320; PMCID: PMC3328620; DOI: 10.1038/mi.2012.14;

Uccellini MB, Busto P, Debatis M, Marshak-Rothstein A, Viglianti GA. Selective binding of anti-DNA antibodies to native dsDNA fragments of differing sequence. Immunol Lett. 2012 Mar 30; 143(1):85-91.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory

PMID: 22285306; PMCID: PMC3655556; DOI: 10.1016/j.imlet.2012.01.003;

Oropallo MA, Kiefer K, Marshak-Rothstein A, Cancro MP. Beyond transitional selection: New roles for BLyS in peripheral tolerance. Drug Dev Res. 2011 Dec; 72(8):779-787. PMID: 22323842

Rosenblum MD, Gratz IK, Paw JS, Lee K, Marshak-Rothstein A, Abbas AK. Response to self antigen imprints regulatory memory in tissues. Nature. 2011 Dec 22; 480(7378):538-42. PMID: 22121024; PMCID: PMC3263357; DOI: 10.1038/nature10664;

Harris JE, Marshak-Rothstein A. Editorial: Interfering with B cell immunity. J Leukoc Biol. 2011 Jun; 89(6):805-6. PMID: 21628334; DOI: 10.1189/jlb.0111042;

Green NM, Marshak-Rothstein A. Toll-like receptor driven B cell activation in the induction of systemic autoimmunity. Semin Immunol. 2011 Apr; 23(2):106-12. PMID: 21306913; PMCID: PMC3070769; DOI: 10.1016/j.smim.2011.01.016;

Gregory MS, Hackett CG, Abernathy EF, Lee KS, Saff RR, Hohlbaum AM, Moody KS, Hobson MW, Jones A, Kolovou P, Karray S, Giani A, John SW, Chen DF, Marshak-Rothstein A, Ksander BR. Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death. PLoS One. 2011; 6(3):e17659. PMID: 21479271; PMCID: PMC3066205; DOI: 10.1371/journal.pone.0017659;

Avalos AM, Uccellini MB, Lenert P, Viglianti GA, Marshak-Rothstein A. Fc?RIIB regulation of BCR/TLR-dependent autoreactive B-cell responses. Eur J Immunol. 2010 Oct; 40(10):2692-8.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory

PMID: 20809520; PMCID: PMC3060940; DOI: 10.1002/eji.200940184;

Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE. G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity. J Exp Med. 2010 Aug 2; 207(8):1775-89. PMID: 20624888; PMCID: PMC2916136; DOI: 10.1084/jem.20092735;

Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, Rifkin IR, Marshak-Rothstein A, Radstake TR, Lafyatis R. Poly(I:C) drives type I IFN- and TGFß-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol. 2010 Nov; 130(11):2583-93.View Related Profiles.

Marshak-Rothstein, Ann
Farina, Giuseppina
Rifkin, Ian
York, Michael
Lafyatis, Robert

PMID: 20613770; PMCID: PMC3086558; DOI: 10.1038/jid.2010.200;

Schoenberger SP, Cheroutre H, Uittenbogaart C, Marshak-Rothstein A. The 2010 Midwinter Conference of Immunologists at Asilomar. Nat Immunol. 2010 May; 11(5):359-61. PMID: 20404845; DOI: 10.1038/ni0510-359;

Avalos AM, Busconi L, Marshak-Rothstein A. Regulation of autoreactive B cell responses to endogenous TLR ligands. Autoimmunity. 2010 Feb; 43(1):76-83. PMID: 20014959; PMCID: PMC3059585; DOI: 10.3109/08916930903374618;

Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ, Marshak-Rothstein A. RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity. 2010 Feb; 43(1):103-10. PMID: 20014975; PMCID: PMC2929824; DOI: 10.3109/08916930903384591;

Richez C, Yasuda K, Bonegio RG, Watkins AA, Aprahamian T, Busto P, Richards RJ, Liu CL, Cheung R, Utz PJ, Marshak-Rothstein A, Rifkin IR. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol. 2010 Jan 15; 184(2):796-806.View Related Profiles.

Watkins, Amanda
Marshak-Rothstein, Ann
Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon
Aprahamian, Tamar

PMID: 20007534; PMCID: PMC2858062; DOI: 10.4049/jimmunol.0901748;

Avalos AM, Latz E, Mousseau B, Christensen SR, Shlomchik MJ, Lund F, Marshak-Rothstein A. Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides. J Immunol. 2009 Nov 15; 183(10):6262-8. PMID: 19864612; PMCID: PMC3426913; DOI: 10.4049/jimmunol.0901941;

Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol. 2009 Sep 1; 183(5):3109-17.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian
Yasuda, Kei
Bonegio, Ramon
Corley, Ronald

PMID: 19648272; PMCID: PMC2860771; DOI: 10.4049/jimmunol.0900399;

Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 1; 183(3):1569-76.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian
van Seventer, Jean
Connor, John
Yasuda, Kei

PMID: 19587008; PMCID: PMC2929820; DOI: 10.4049/jimmunol.0803899;

Lenert P, Yasuda K, Busconi L, Nelson P, Fleenor C, Ratnabalasuriar RS, Nagy PL, Ashman RF, Rifkin IR, Marshak-Rothstein A. DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo. Arthritis Res Ther. 2009; 11(3):R79.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian
Yasuda, Kei

PMID: 19476613; PMCID: PMC2714127; DOI: 10.1186/ar2710;

Uccellini MB, Avalos AM, Marshak-Rothstein A, Viglianti GA. Toll-like receptor-dependent immune complex activation of B cells and dendritic cells. Methods Mol Biol. 2009; 517:363-80.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory

PMID: 19378022; DOI: 10.1007/978-1-59745-541-1_22;

Uccellini MB, Busconi L, Green NM, Busto P, Christensen SR, Shlomchik MJ, Marshak-Rothstein A, Viglianti GA. Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha. J Immunol. 2008 Nov 1; 181(9):5875-84.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory

PMID: 18941176; PMCID: PMC2584609; DOI: 10.4049/jimmunol.181.9.5875;

Gregory MS, Saff RR, Marshak-Rothstein A, Ksander BR. Control of ocular tumor growth and metastatic spread by soluble and membrane Fas ligand. Cancer Res. 2007 Dec 15; 67(24):11951-8. PMID: 18089826

Marshak-Rothstein A, Ohashi PS. Intricate connections between innate and adaptive autoimmunity. Curr Opin Immunol. 2007 Dec; 19(6):603-5. PMID: 18083508

Busconi L, Bauer JW, Tumang JR, Laws A, Perkins-Mesires K, Tabor AS, Lau C, Corley RB, Rothstein TL, Lund FE, Behrens TW, Marshak-Rothstein A. Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9. J Immunol. 2007 Dec 1; 179(11):7397-405.View Related Profiles.

Marshak-Rothstein, Ann
Corley, Ronald

PMID: 18025183

Yasuda K, Richez C, Maciaszek JW, Agrawal N, Akira S, Marshak-Rothstein A, Rifkin IR. Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. J Immunol. 2007 Jun 1; 178(11):6876-85.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian
Yasuda, Kei

PMID: 17513736

Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, Parroche P, Drabic S, Golenbock D, Sirois C, Hua J, An LL, Audoly L, La Rosa G, Bierhaus A, Naworth P, Marshak-Rothstein A, Crow MK, Fitzgerald KA, Latz E, Kiener PA, Coyle AJ. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol. 2007 May; 8(5):487-96. PMID: 17417641

Lafyatis R, Marshak-Rothstein A. Toll-like receptors and innate immune responses in systemic lupus erythematosus. Arthritis Res Ther. 2007; 9(6):222.View Related Profiles.

Marshak-Rothstein, Ann
Lafyatis, Robert

PMID: 18086320; PMCID: PMC2246252; DOI: 10.1186/ar2321;

Marshak-Rothstein A, Rifkin IR. Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol. 2007; 25:419-41.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 17378763

Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol. 2006 Nov; 6(11):823-35. PMID: 17063184

Lafyatis R, York M, Marshak-Rothstein A. Antimalarial agents: closing the gate on Toll-like receptors? Arthritis Rheum. 2006 Oct; 54(10):3068-70.View Related Profiles.

Marshak-Rothstein, Ann
York, Michael
Lafyatis, Robert

PMID: 17009223

Marshak-Rothstein A. Tolling for autoimmunity-prime time for 7. Immunity. 2006 Sep; 25(3):397-9. PMID: 16979573

Beaudette-Zlatanova BC, Ling T, Shlomchik MJ, Marshak-Rothstein A, Rifkin IR. B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells. J Immunol. 2006 Jul 1; 177(1):45-52.View Related Profiles.

Marshak-Rothstein, Ann
Beaudette-Zlatanova, Britte
Rifkin, Ian

PMID: 16785497

Busconi L, Lau CM, Tabor AS, Uccellini MB, Ruhe Z, Akira S, Viglianti GA, Rifkin IR, Marshak-Rothstein A. DNA and RNA autoantigens as autoadjuvants. J Endotoxin Res. 2006; 12(6):379-84.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian

PMID: 17254393

Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med. 2005 Nov 7; 202(9):1171-7.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian

PMID: 16260486; PMCID: PMC2213226; DOI: 10.1084/jem.20050630;

Gregory MS, Koh S, Huang E, Saff RR, Marshak-Rothstein A, Mukai S, Ksander BR. A novel treatment for ocular tumors using membrane FasL vesicles to activate innate immunity and terminate immune privilege. Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2495-502. PMID: 15980241

William J, Euler C, Leadbetter E, Marshak-Rothstein A, Shlomchik MJ. Visualizing the onset and evolution of an autoantibody response in systemic autoimmunity. J Immunol. 2005 Jun 1; 174(11):6872-8. PMID: 15905529

Rifkin IR, Leadbetter EA, Busconi L, Viglianti G, Marshak-Rothstein A. Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol Rev. 2005 Apr; 204:27-42.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian

PMID: 15790348

Funatake CJ, Dearstyne EA, Steppan LB, Shepherd DM, Spanjaard ES, Marshak-Rothstein A, Kerkvliet NI. Early consequences of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on the activation and survival of antigen-specific T cells. Toxicol Sci. 2004 Nov; 82(1):129-42. PMID: 15310856

Marshak-Rothstein A, Busconi L, Rifkin IR, Viglianti GA. The stimulation of Toll-like receptors by nuclear antigens: a link between apoptosis and autoimmunity. Rheum Dis Clin North Am. 2004 Aug; 30(3):559-74, ix.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian

PMID: 15261341

Boulé MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med. 2004 Jun 21; 199(12):1631-40.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 15197227; PMCID: PMC2212813

Saff RR, Spanjaard ES, Hohlbaum AM, Marshak-Rothstein A. Activation-induced cell death limits effector function of CD4 tumor-specific T cells. J Immunol. 2004 Jun 1; 172(11):6598-606. PMID: 15153474

Xiao S, Zhang X, Mann KK, Jodo S, Li L, Jarjour WN, Marshak-Rothstein A, Sherr DH, Ju ST. Changes in sensitivity of peripheral lymphocytes of autoimmune gld mice to FasL-mediated apoptosis reveal a mechanism for the preferential deletion of CD4-CD8-B220+ T cells. Int Immunol. 2004 May; 16(5):759-66.View Related Profiles.

Marshak-Rothstein, Ann
Sherr, David

PMID: 15096479

Marshak-Rothstein A, Busconi L, Lau CM, Tabor AS, Leadbetter EA, Akira S, Krieg AM, Lipford GB, Viglianti GA, Rifkin IR. Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells. J Endotoxin Res. 2004; 10(4):247-51.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory
Rifkin, Ian

PMID: 15373969

Viglianti GA, Lau CM, Hanley TM, Miko BA, Shlomchik MJ, Marshak-Rothstein A. Activation of autoreactive B cells by CpG dsDNA. Immunity. 2003 Dec; 19(6):837-47.View Related Profiles.

Marshak-Rothstein, Ann
Viglianti, Gregory

PMID: 14670301

Rifkin IR, Marshak-Rothstein A. T-bet: the Toll-bridge to class-switch recombination? Nat Immunol. 2003 Jul; 4(7):650-2.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 12830144

Leadbetter EA, Rifkin IR, Marshak-Rothstein A. Toll-like receptors and activation of autoreactive B cells. Curr Dir Autoimmun. 2003; 6:105-22.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 12408049

Xiao S, Jodo S, Sung SS, Marshak-Rothstein A, Ju ST. A novel signaling mechanism for soluble CD95 ligand. Synergy with anti-CD95 monoclonal antibodies for apoptosis and NF-kappaB nuclear translocation. J Biol Chem. 2002 Dec 27; 277(52):50907-13. PMID: 12393889

Gregory MS, Repp AC, Holhbaum AM, Saff RR, Marshak-Rothstein A, Ksander BR. Membrane Fas ligand activates innate immunity and terminates ocular immune privilege. J Immunol. 2002 Sep 1; 169(5):2727-35. PMID: 12193747

Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 2002 Apr 11; 416(6881):603-7.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 11948342

Hohlbaum AM, Saff RR, Marshak-Rothstein A. Fas-ligand--iron fist or Achilles' heel? Clin Immunol. 2002 Apr; 103(1):1-6. PMID: 11987979

Hohlbaum AM, Gregory MS, Ju ST, Marshak-Rothstein A. Fas ligand engagement of resident peritoneal macrophages in vivo induces apoptosis and the production of neutrophil chemotactic factors. J Immunol. 2001 Dec 1; 167(11):6217-24. PMID: 11714783

Xiao S, Marshak-Rothstein A, Ju ST. Sp1 is the major fasl gene activator in abnormal CD4(-)CD8(-)B220(+) T cells of lpr and gld mice. Eur J Immunol. 2001 Nov; 31(11):3339-48. PMID: 11745351

Jodo S, Xiao S, Hohlbaum A, Strehlow D, Marshak-Rothstein A, Ju ST. Apoptosis-inducing membrane vesicles. A novel agent with unique properties. J Biol Chem. 2001 Oct 26; 276(43):39938-44. PMID: 11546786

Jodo S, Hohlbaum AM, Xiao S, Chan D, Strehlow D, Sherr DH, Marshak-Rothstein A, Ju ST. CD95 (Fas) ligand-expressing vesicles display antibody-mediated, FcR-dependent enhancement of cytotoxicity. J Immunol. 2000 Nov 15; 165(10):5487-94.View Related Profiles.

Marshak-Rothstein, Ann
Sherr, David

PMID: 11067901

Rifkin IR, Leadbetter EA, Beaudette BC, Kiani C, Monestier M, Shlomchik MJ, Marshak-Rothstein A. Immune complexes present in the sera of autoimmune mice activate rheumatoid factor B cells. J Immunol. 2000 Aug 1; 165(3):1626-33.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 10903773

Zhu B, Beaudette BC, Rifkin IR, Marshak-Rothstein A. Double mutant MRL-lpr/lpr-gld/gld cells fail to trigger lpr-graft-versus-host disease in syngeneic wild-type recipient mice, but can induce wild-type B cells to make autoantibody. Eur J Immunol. 2000 Jun; 30(6):1778-84.View Related Profiles.

Marshak-Rothstein, Ann
Beaudette-Zlatanova, Britte
Rifkin, Ian

PMID: 10898516

Gochuico BR, Zhang J, Ma BY, Marshak-Rothstein A, Fine A. TRAIL expression in vascular smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2000 May; 278(5):L1045-50.View Related Profiles.

Fine, Alan
Marshak-Rothstein, Ann

PMID: 10781437

Hohlbaum AM, Moe S, Marshak-Rothstein A. Opposing effects of transmembrane and soluble Fas ligand expression on inflammation and tumor cell survival. J Exp Med. 2000 Apr 3; 191(7):1209-20. PMID: 10748238; PMCID: PMC2193164

Wang JK, Ju ST, Marshak-Rothstein A. Protection of T cells from activation-induced cell death by Fas+ B cells. Eur J Immunol. 2000 Mar; 30(3):931-7. PMID: 10741411

Boes M, Schmidt T, Linkemann K, Beaudette BC, Marshak-Rothstein A, Chen J. Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM. Proc Natl Acad Sci U S A. 2000 Feb 1; 97(3):1184-9.View Related Profiles.

Marshak-Rothstein, Ann
Beaudette-Zlatanova, Britte

PMID: 10655505; PMCID: PMC15562

Xiao S, Matsui K, Fine A, Zhu B, Marshak-Rothstein A, Widom RL, Ju ST. FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3. Eur J Immunol. 1999 Nov; 29(11):3456-65.View Related Profiles.

Fine, Alan
Marshak-Rothstein, Ann

PMID: 10556800

Zhang J, Ma B, Marshak-Rothstein A, Fine A. Characterization of a novel cis-element that regulates Fas ligand expression in corneal endothelial cells. J Biol Chem. 1999 Sep 10; 274(37):26537-42. PMID: 10473616

Rifkin IR, Marshak-Rothstein A. Fas and Fas ligand in autoimmunity. Curr Dir Autoimmun. 1999; 1:31-55.View Related Profiles.

Marshak-Rothstein, Ann
Rifkin, Ian

PMID: 11791447

Morgan G, Smith S, Pak J, Marshak-Rothstein A, Fissore R, Osborne B. Characterization of a mutant T-cell hybridoma line with defects in the TCR-mediated apoptotic pathway. Cell Death Differ. 1999 Jan; 6(1):36-47. PMID: 10200546

Rifkin IR, Channavajhala PL, Kiefer HL, Carmack AJ, Landesman-Bollag E, Beaudette BC, Jersky B, Salant DJ, Ju ST, Marshak-Rothstein A, Seldin DC. Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15; 161(10):5164-70.View Related Profiles.

Marshak-Rothstein, Ann
Beaudette-Zlatanova, Britte
Seldin, David
Salant, David
Landesman, Esther
Rifkin, Ian

PMID: 9820486

Matsui K, Fine A, Zhu B, Marshak-Rothstein A, Ju ST. Identification of two NF-kappa B sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma. J Immunol. 1998 Oct 1; 161(7):3469-73.View Related Profiles.

Fine, Alan
Marshak-Rothstein, Ann

PMID: 9759866

Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, Torres Arzayus MI, Priestley A, Jackson SP, Marshak Rothstein A, Jeggo PA, Herrera VL. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity. 1998 Sep; 9(3):355-66.View Related Profiles.

Marshak-Rothstein, Ann
Herrera, Victoria

PMID: 9768755

Foote LC, Marshak-Rothstein A, Rothstein TL. Tolerant B lymphocytes acquire resistance to Fas-mediated apoptosis after treatment with interleukin 4 but not after treatment with specific antigen unless a surface immunoglobulin threshold is exceeded. J Exp Med. 1998 Mar 16; 187(6):847-53. PMID: 9500787; PMCID: PMC2212184

Wang JK, Zhu B, Ju ST, Tschopp J, Marshak-Rothstein A. CD4+ T cells reactivated with superantigen are both more sensitive to FasL-mediated killing and express a higher level of FasL. Cell Immunol. 1997 Aug 1; 179(2):153-64. PMID: 9268499

Foote LC, Marshak-Rothstein A, Rothstein TL. Inducible Fas-resistance mediated by IL-4 in activated B cells. Ann N Y Acad Sci. 1997 Apr 5; 815:114-5. PMID: 9186645

Jacobson BA, Foote LC, Panka DJ, Ju ST, Rothstein TL, Marshak-Rothstein A. Unique site of autoantibody production in Fas-deficient mice. Ann N Y Acad Sci. 1997 Apr 5; 815:218-29. PMID: 9186658

Jacobson BA, Rothstein TL, Marshak-Rothstein A. Unique site of IgG2a and rheumatoid factor production in MRL/lpr mice. Immunol Rev. 1997 Apr; 156:103-10. PMID: 9176703

Elkon KB, Marshak-Rothstein A. B cells in systemic autoimmune disease: recent insights from Fas-deficient mice and men. Curr Opin Immunol. 1996 Dec; 8(6):852-9. PMID: 8994866

Jacobson BA, Rothstein TL, Marshak-Rothstein A. The role of Fas/FasL interactions in the regulation of B cell function. Behring Inst Mitt. 1996 Oct; (97):185-99. PMID: 8950476

Foote LC, Howard RG, Marshak-Rothstein A, Rothstein TL. IL-4 induces Fas resistance in B cells. J Immunol. 1996 Oct 1; 157(7):2749-53. PMID: 8816375

Foote LC, Schneider TJ, Fischer GM, Wang JK, Rasmussen B, Campbell KA, Lynch DH, Ju ST, Marshak-Rothstein A, Rothstein TL. Intracellular signaling for inducible antigen receptor-mediated Fas resistance in B cells. J Immunol. 1996 Sep 1; 157(5):1878-85. PMID: 8757305

Christianson GJ, Blankenburg RL, Duffy TM, Panka D, Roths JB, Marshak-Rothstein A, Roopenian DC. beta2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice. J Immunol. 1996 Jun 15; 156(12):4932-9. PMID: 8648144

Perkins DL, Listman JA, Marshak-Rothstein A, Kozlow W, Kelley VR, Finn PW, Rimm IJ. Restriction of the TCR repertoire inhibits the development of memory T cells and prevents autoimmunity in lpr mice. J Immunol. 1996 Jun 15; 156(12):4961-8. PMID: 8648148

Cui H, Sherr DH, el-Khatib M, Matsui K, Panka DJ, Marshak-Rothstein A, Ju ST. Regulation of T-cell death genes: selective inhibition of FasL- but not Fas-mediated function. Cell Immunol. 1996 Feb 1; 167(2):276-84.View Related Profiles.

Marshak-Rothstein, Ann
Sherr, David

PMID: 8603437

Cui H, el-Khatib M, Sherr DH, Ettinger R, Sy MS, Marshak-Rothstein A, Ju ST. Characterization of lpr-derived T cell hybridomas: Fas-deficient hybridomas are deathless, growth-arrested, and cytotoxic upon activation. Cell Immunol. 1996 Feb 1; 167(2):302-12.View Related Profiles.

Marshak-Rothstein, Ann
Sherr, David

PMID: 8603440

Ozdemirli M, El-Khatib M, Foote LC, Wang JK, Marshak-Rothstein A, Rothstein TL, Ju ST. Fas (CD95)/Fas ligand interactions regulate antigen-specific, major histocompatibility complex-restricted T/B cell proliferative responses. Eur J Immunol. 1996 Feb; 26(2):415-9. PMID: 8617312

Rothstein TL, Foote LC, Schneider TJ, Fischer GM, Jacobson BA, Lynch DH, Ju ST, Marshak-Rothstein A. Inducible resistance to Fas-mediated apoptosis in primary B lymphocytes. Adv Exp Med Biol. 1996; 406:177-89. PMID: 8910684

Jacobson BA, Panka DJ, Nguyen KA, Erikson J, Abbas AK, Marshak-Rothstein A. Anatomy of autoantibody production: dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice. Immunity. 1995 Oct; 3(4):509-19. PMID: 7584141

Israel EJ, Patel VK, Taylor SF, Marshak-Rothstein A, Simister NE. Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. J Immunol. 1995 Jun 15; 154(12):6246-51. PMID: 7759862

Ettinger R, Panka DJ, Wang JK, Stanger BZ, Ju ST, Marshak-Rothstein A. Fas ligand-mediated cytotoxicity is directly responsible for apoptosis of normal CD4+ T cells responding to a bacterial superantigen. J Immunol. 1995 May 1; 154(9):4302-8. PMID: 7536768

Rothstein TL, Wang JK, Panka DJ, Foote LC, Wang Z, Stanger B, Cui H, Ju ST, Marshak-Rothstein A. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature. 1995 Mar 9; 374(6518):163-5. PMID: 7533263

Ju ST, Panka DJ, Cui H, Ettinger R, el-Khatib M, Sherr DH, Stanger BZ, Marshak-Rothstein A. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature. 1995 Feb 2; 373(6513):444-8.View Related Profiles.

Marshak-Rothstein, Ann
Sherr, David

PMID: 7530337

Panka DJ, Salant DJ, Jacobson BA, Minto AW, Marshak-Rothstein A. The effect of VH residues 6 and 23 on IgG3 cryoprecipitation and glomerular deposition. Eur J Immunol. 1995 Jan; 25(1):279-84.View Related Profiles.

Marshak-Rothstein, Ann
Salant, David

PMID: 7843244

Shan H, Shlomchik MJ, Marshak-Rothstein A, Pisetsky DS, Litwin S, Weigert MG. The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. J Immunol. 1994 Dec 1; 153(11):5104-20. PMID: 7525723

Singer GG, Carrera AC, Marshak-Rothstein A, Martínez C, Abbas AK. Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model. Curr Opin Immunol. 1994 Dec; 6(6):913-20. PMID: 7536012

Ju ST, Cui H, Panka DJ, Ettinger R, Marshak-Rothstein A. Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4185-9. PMID: 7514297; PMCID: PMC43749

Jacobson BA, Sharon J, Shan H, Shlomchik M, Weigert MG, Marshak-Rothstein A. An isotype switched and somatically mutated rheumatoid factor clone isolated from a MRL-lpr/lpr mouse exhibits limited intraclonal affinity maturation. J Immunol. 1994 May 1; 152(9):4489-99.View Related Profiles.

Marshak-Rothstein, Ann
Sharon, Jacqueline

PMID: 8157964

Ettinger R, Wang JK, Bossu P, Papas K, Sidman CL, Abbas AK, Marshak-Rothstein A. Functional distinctions between MRL-lpr and MRL-gld lymphocytes. Normal cells reverse the gld but not lpr immunoregulatory defect. J Immunol. 1994 Feb 15; 152(4):1557-68. PMID: 8120369

Bossu P, Singer GG, Andres P, Ettinger R, Marshak-Rothstein A, Abbas AK. Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. J Immunol. 1993 Dec 15; 151(12):7233-9. PMID: 7903104

Very DL, Panka DJ, Weissman D, Wysocki L, Manser T, Marshak-Rothstein A. Lack of connectivity between the induced and autoimmune repertoires of lpr/lpr mice. Immunology. 1993 Dec; 80(4):518-26. PMID: 8307604; PMCID: PMC1422265

Levine JS, Pugh BJ, Hartwell D, Fitzpatrick JM, Marshak-Rothstein A, Beller DI. Interleukin-1 dysregulation is an intrinsic defect in macrophages from MRL autoimmune-prone mice. Eur J Immunol. 1993 Nov; 23(11):2951-8. PMID: 8223873

Panka DJ, Very DL, Jacobson BA, Kussie PH, Parhami-Seren B, Margolies MN, Marshak-Rothstein A. Defining the structural correlates responsible for loss of arsonate affinity in an IDCR antibody isolated from an autoimmune mouse. Mol Immunol. 1993 Aug; 30(11):1013-20. PMID: 8350871

Glaser RM, Mahon CA, Marshak-Rothstein A. Persistence of lpr/lpr-derived IgG2a secreting B cells in normal----lpr/lpr adult radiation chimeras or lpr/lpr----normal kidney capsule chimeras. Cell Immunol. 1992 Jul; 142(2):313-25. PMID: 1623555

Berney T, Fulpius T, Shibata T, Reininger L, Van Snick J, Shan H, Weigert M, Marshak-Rothstein A, Izui S. Selective pathogenicity of murine rheumatoid factors of the cryoprecipitable IgG3 subclass. Int Immunol. 1992 Jan; 4(1):93-9. PMID: 1540551

Nemazee D, Guiet C, Buerki K, Marshak-Rothstein A. B lymphocytes from the autoimmune-prone mouse strain MLR/lpr manifest an intrinsic defect in tetraparental MRL/lpr in equilibrium DBA/2 chimeras. J Immunol. 1991 Oct 15; 147(8):2536-9. PMID: 1918976

Glaser RM, Marshak-Rothstein A. Resistance to lymphoid engraftment in lpr recipients of normal bone marrow: characterization of chimeric stem cell, monocyte and peripheral lymphoid lineages. Eur J Immunol. 1990 Sep; 20(9):1917-25. PMID: 2209698

Perkins DL, Glaser RM, Mahon CA, Michaelson J, Marshak-Rothstein A. Evidence for an intrinsic B cell defect in lpr/lpr mice apparent in neonatal chimeras. J Immunol. 1990 Jul 15; 145(2):549-55. PMID: 2365994

Traish AM, Ettinger R, Kim N, Marshak-Rothstein A, Wotiz HH. Development and characterization of monoclonal antibodies to a specific domain of human estrogen receptor. Steroids. 1990 May; 55(5):196-208.View Related Profiles.

Traish, Abdulmaged
Marshak-Rothstein, Ann

PMID: 2360217

Shlomchik M, Mascelli M, Shan H, Radic MZ, Pisetsky D, Marshak-Rothstein A, Weigert M. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med. 1990 Jan 1; 171(1):265-92. PMID: 2104919; PMCID: PMC2187662

Wolfowicz CB, Lyons S, Mahon CA, Marshak-Rothstein A, Rothstein TL. Isolation of self-recognizing IgG2a monoclonal rheumatoid factors. Clin Immunol Immunopathol. 1989 Aug; 52(2):313-22. PMID: 2736811

Yamada K, Spezialetti R, Marshak-Rothstein A, Sy MS. Autoantibody in MRL/Mp-lpr/lpr mice. A monoclonal antibody specific for the abnormal T cells from mice bearing the lpr/lpr gene. J Immunol. 1989 Apr 15; 142(8):2702-7. PMID: 2649559

Marshak-Rothstein A. Origins of autoantibodies. Curr Opin Immunol. 1989 Apr; 1(4):697-700. PMID: 2679722

Bonfa E, Marshak-Rothstein A, Weissbach H, Brot N, Elkon K. Frequency and epitope recognition of anti-ribosome P antibodies from humans with systemic lupus erythematosus and MRL/lpr mice are similar. J Immunol. 1988 May 15; 140(10):3434-7. PMID: 2452189

Wolfowicz CB, Sakorafas P, Rothstein TL, Marshak-Rothstein A. Oligoclonality of rheumatoid factors arising spontaneously in lpr/lpr mice. Clin Immunol Immunopathol. 1988 Mar; 46(3):382-95. PMID: 3338196

Perkins DL, Michaelson J, Glaser RM, Marshak-Rothstein A. Selective elimination of non-lpr lymphoid cells in mice undergoing lpr-mediated graft-vs-host disease. J Immunol. 1987 Sep 1; 139(5):1406-13. PMID: 2887617

Shlomchik MJ, Marshak-Rothstein A, Wolfowicz CB, Rothstein TL, Weigert MG. The role of clonal selection and somatic mutation in autoimmunity. Nature. 1987 Aug 27-Sep 2; 328(6133):805-11. PMID: 3498121

Perkins DL, Michaelson J, Marshak-Rothstein A. The lpr gene is associated with resistance to engraftment by lymphoid but not erythroid stem cells from normal mice. J Immunol. 1987 Jan 15; 138(2):466-9. PMID: 2878956

Weissman D, Parker DJ, Rothstein TL, Marshak-Rothstein A. Methods for the production of xenogeneic monoclonal antibodies in murine ascites. J Immunol. 1985 Aug; 135(2):1001-3. PMID: 4008923

Weissman D, Rothstein TL, Marshak-Rothstein A. A rapid method for comparing monoclonal antibodies by limited proteolysis and electrophoresis. Hybridoma. 1985; 4(4):329-39. PMID: 3905580

Groopman JD, Trudel LJ, Donahue PR, Marshak-Rothstein A, Wogan GN. High-affinity monoclonal antibodies for aflatoxins and their application to solid-phase immunoassays. Proc Natl Acad Sci U S A. 1984 Dec; 81(24):7728-31. PMID: 6440143; PMCID: PMC392225

McCormack JE, Pepe VH, Kent RB, Dean M, Marshak-Rothstein A, Sonenshein GE. Specific regulation of c-myc oncogene expression in a murine B-cell lymphoma. Proc Natl Acad Sci U S A. 1984 Sep; 81(17):5546-50.View Related Profiles.

Marshak-Rothstein, Ann
Sonenshein, Gail

PMID: 6206500; PMCID: PMC391743

Rothstein TL, Miller RA, Parker DJ, Kelly E, Vastola AP, Marshak-Rothstein A. Induction of idiotope suppression in the anti-azophenylarsonate response of T-depleted A/J mice. J Exp Med. 1984 Apr 1; 159(4):1283-8. PMID: 6608575; PMCID: PMC2187275

McCormack JE, Kent RB, Pepe VH, Dean M, Marshak-Rothstein A, Sonenshein GE. Immune regulation of the c-myc oncogene in a murine B lymphoma. Curr Top Microbiol Immunol. 1984; 113:127-32.View Related Profiles.

Marshak-Rothstein, Ann
Sonenshein, Gail

PMID: 6332712

Rothstein TL, Margolies MN, Gefter ML, Marshak-Rothstein A. Fine specificity of idiotope suppression in the A/J anti-azophenylarsonate response. J Exp Med. 1983 Feb 1; 157(2):795-800. PMID: 6185619; PMCID: PMC2186940

Margolies MN, Juszczak EC, Near R, Marshak-Rothstein A, Rothstein TL, Sato VL, Siekevitz M, Smith JA, Wysocki LJ, Gefter ML. Structural correlates of idiotypy in the arsonate system. Ann N Y Acad Sci. 1983; 418:48-64.View Related Profiles.

Marshak-Rothstein, Ann
Near, Richard

PMID: 6424532

Siekevitz M, Gefter ML, Brodeur P, Riblet R, Marshak-Rothstein A. The genetic basis of antibody production: the dominant anti-arsonate idiotype response of the strain A mouse. Eur J Immunol. 1982 Dec; 12(12):1023-32. PMID: 6186498

Margolies MN, Marshak-Rothstein A, Gefter ML. Structural diversity among anti-p-azophenylarsonate monoclonal antibodies from A/J mice; comparison of Id- and Id+ sequences. Mol Immunol. 1981 Dec; 18(12):1065-77. PMID: 6801478

Marshak-Rothstein A, Margolies MN, Benedetto JD, Gefter ML. Two structurally distinct and independently regulated idiotypic families associated with the A/J response to azophenylarsonate. Eur J Immunol. 1981 Jul; 11(7):565-72. PMID: 7286063

Schwartz AL, Marshak-Rothstein A, Rup D, Lodish HF. Identification and quantification of the rat hepatocyte asialoglycoprotein receptor. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3348-52. PMID: 6267585; PMCID: PMC319565

Marshak-Rothstein A, Benedetto JD, Kirsch RL, Gefter ML. Unique determinants associated with hybridoma proteins expressing a cross-reactive idiotype: frequency among individual immune sera. J Immunol. 1980 Nov; 125(5):1987-92. PMID: 6159397

Marshak-Rothstein A, Siekevitz M, Margolies MN, Mudgett-Hunter M, Gefter ML. Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J mice. Proc Natl Acad Sci U S A. 1980 Feb; 77(2):1120-4. PMID: 6767242; PMCID: PMC348436

Gottlieb PD, Marshak-Rothstein A, Auditore-Hargreaves K, Berkoben DB, August DA, Rosche RM, Benedetto JD. Construction and properties of new Lyt-congenic strains and anti-Lyt-2.2 and anti-Lyt-3.1 monoclonal antibodies. Immunogenetics. 1980; 10(6):545-55. PMID: 22457935

Marshak-Rothstein A, Fink P, Gridley T, Raulet DH, Bevan MJ, Gefter ML. Properties and applications of monoclonal antibodies directed against determinants of they Thy-1 locus. J Immunol. 1979 Jun; 122(6):2491-7. PMID: 87465

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Contact for Mentoring:

Yr	Title	Project-Sub Proj	Pubs
2024	Radioresistant Innate Immunity in SAVI Tissue-Specific Autoinflammation	5R21AI178978-02
2024	Mechanisms of STING-driven autoinflammation	5R01HL165787-02
2024	Fas Ligand Cleavage regulates ocular homeostasis and glaucoma	5R01EY032762-03
2024	The role of TLRs, Type II IFN and Type III IFN in a Murine Model of Autoinflammation	5R37AI155901-04
2024	Training in the Molecular Basis of Autoimmunity and Autoinflammation	5T32AI132152-07
2023	Radioresistant Innate Immunity in SAVI Tissue-Specific Autoinflammation	1R21AI178978-01
2023	Mechanisms of STING-driven autoinflammation	1R01HL165787-01A1
2023	Fas Ligand Cleavage regulates ocular homeostasis and glaucoma	5R01EY032762-02
2023	Fas Ligand Cleavage regulates ocular homeostasis and glaucoma	3R01EY032762-02S1
2023	The role of TLRs, Type II IFN and Type III IFN in a Murine Model of Autoinflammation	5R37AI155901-03
2023	Training in the Molecular Basis of Autoimmunity and Autoinflammation	2T32AI132152-06
2022	Fas Ligand Cleavage regulates ocular homeostasis and glaucoma	1R01EY032762-01A1
2022	The role of TLRs, Type II IFN and Type III IFN in a Murine Model of Autoinflammation	5R37AI155901-02
2022	Training in the Molecular Basis of Autoimmunity and Autoinflammation	5T32AI132152-05
2021	The role of TLRs, Type II IFN and Type III IFN in a Murine Model of Autoinflammation	1R01AI155901-01
2021	Training in the Molecular Basis of Autoimmunity and Autoinflammation	5T32AI132152-04	2
2021	Regulation of Lupus by Cytosolic DNA Sensors	5R01AI128358-05	4
2020	Mechanisms by which TLR9-deficiency and FasL Promote Cutaneous Lupus	5R21AI145097-02	1
2020	Training in the Molecular Basis of Autoimmunity and Autoinflammation	5T32AI132152-03	2
2020	Regulation of Lupus by Cytosolic DNA Sensors	5R01AI128358-04	4
2019	Mechanisms by which TLR9-deficiency and FasL Promote Cutaneous Lupus	1R21AI145097-01	1
2019	Training in the Molecular Basis of Autoimmunity and Autoinflammation	5T32AI132152-02	2
2019	Innate Immune activation of Cutaneous Lupus	5R21AI136253-02
2019	Regulation of Lupus by Cytosolic DNA Sensors	5R01AI128358-03	4
2019	Distinct Functional Outcomes of BCR/TLR7 and BCR/TLR9 Co-engagement	5R01AR066808-05	17
2018	Training in the Molecular Basis of Autoimmunity and Autoinflammation	1T32AI132152-01A1	2
2018	Innate Immune activation of Cutaneous Lupus	1R21AI136253-01A1
2018	Regulation of Lupus by Cytosolic DNA Sensors	5R01AI128358-02	4
2018	Distinct Functional Outcomes of BCR/TLR7 and BCR/TLR9 Co-engagement	5R01AR066808-04	17
2017	Regulation of Lupus by Cytosolic DNA Sensors	1R01AI128358-01	4
2017	Distinct Functional Outcomes of BCR/TLR7 and BCR/TLR9 Co-engagement	5R01AR066808-03	17
2016	Distinct Functional Outcomes of BCR/TLR7 and BCR/TLR9 Co-engagement	5R01AR066808-02	17
2015	Distinct Functional Outcomes of BCR/TLR7 and BCR/TLR9 Co-engagement	1R01AR066808-01A1	17
2013	Activation of B Cells by Host Toll-Like Receptor Ligands	5P01AR050256-11-6673	66
2013	CO-FUNDING-NIAID	5P01AR050256-11-5994	66
2013	Toll-Like Receptors in Systemic Autoimmune Disease	5P01AR050256-11	66
2012	Immunological Mechanisms in Systemic Autoimmune Disease	5R01AR055634-05	5
2012	Toll-Like Receptors in Systemic Autoimmune Disease	5P01AR050256-10	66
2012	Activation of B Cells by Host Toll-Like Receptor Ligands	5P01AR050256-10-6673	66
2012	CO-FUNDING-NIAID	5P01AR050256-10-5994	66
2011	CO-FUNDING-NIAID	5P01AR050256-09-5994	66
2011	Activation of B Cells by Host Toll-Like Receptor Ligands	5P01AR050256-09-6673	66
2011	Immunological Mechanisms in Systemic Autoimmune Disease	5R01AR055634-04	5
2011	Toll-Like Receptors in Systemic Autoimmune Disease	5P01AR050256-09	66
2010	Activation of B Cells by Host Toll-Like Receptor Ligands	5P01AR050256-08-6673	66
2010	CO-FUNDING-NIAID	5P01AR050256-08-5994	66
2010	Immunological Mechanisms in Systemic Autoimmune Disease	7R01AR055634-03	5
2010	Toll-Like Receptors in Systemic Autoimmune Disease	5P01AR050256-08	66
2010	B Cell Hyperactivity in Autoimmunity	5R01AR035230-24	46
2009	Immunological Mechanisms in Systemic Autoimmune Disease	5R01AR055634-02	5
2009	Toll-Like Receptors in Systemic Autoimmune Disease	7P01AR050256-07	66
2009	Toll-Like Receptors in Systemic Autoimmune Disease	2P01AR050256-06	66
2009	B Cell Hyperactivity in Autoimmunity	7R01AR035230-23	46
2009	B Cell Hyperactivity in Autoimmunity	5R01AR035230-22	46
2009	Activation of B Cells by Host Toll-Like Receptor Ligands	7P01AR050256-07-6673	66
2009	Activation of B Cells by Host Toll-Like Receptor Ligands	2P01AR050256-06-6673	66
2008	Immunological Mechanisms in Systemic Autoimmune Disease	1R01AR055634-01A1	5
2008	Activation of B Cells by Host Toll-like Receptor Ligands	5P01AR050256-05-1	66
2008	Toll-Like Receptors in Systemic Autoimmune Disease	5P01AR050256-05	66
2008	B Cell Hyperactivity in Autoimmunity	5R01AR035230-21	46
2007	Activation of B Cells by Host Toll-Like Receptor Ligands	5P01AR050256-04-1	66
2007	Administrative Core	5P01AR050256-04-9002	66
2007	Toll-Like Receptors in Systemic Autoimmune Disease	5P01AR050256-04	66
2007	Research Program in Immunology	5T32AI007309-20	73
2007	B Cell Hyperactivity in Autoimmunity	5R01AR035230-20	46
2006	Toll-Like Receptors in Systemic Autoimmune Disease	5P01AR050256-03	66
2006	Research Program in Immunology	5T32AI007309-19	73
2006	B Cell Hyperactivity in Autoimmunity	2R01AR035230-19A1	46
2006	Activation of B Cells by Host Toll-Like Receptor Ligands	5P01AR050256-03-1	66
2005	Toll-Like Receptors in Systemic Autoimmune Disease	5P01AR050256-02	66
2005	Functions of Transmembrane and Soluble Fas ligand	5R01CA090691-05	11
2005	Research Program in Immunology	5T32AI007309-18	73
2005	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-18	46
2005	Activation of B Cells by Host Toll-Like Receptor Ligands	5P01AR050256-02-1	66
2004	Toll-Like Receptors in Systemic Autoimmune Disease	1P01AR050256-01A1	66
2004	Activation of B Cells by Host Toll-Like Receptor Ligands	1P01AR050256-01A1-1	66
2004	Functions of Transmembrane and Soluble Fas ligand	5R01CA090691-04	11
2004	Research Program in Immunology	5T32AI007309-17	73
2004	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-17	46
2003	TLR/BCR Synergy in an Autoreactive B Cell Activation	1R01AR050446-01	2
2003	Functions of Transmembrane and Soluble Fas ligand	5R01CA090691-03	11
2003	Research Program in Immunology	2T32AI007309-16	73
2003	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-16	46
2002	CORE--ANIMAL FACILITY	5P01AI050516-02-9001	10
2002	Functions of Transmembrane and Soluble Fas ligand	5R01CA090691-02	11
2002	RESEARCH TRAINING IN IMMUNOLOGY	5T32AI007309-15	73
2002	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-15	46
2001	Functions of Transmembrane and Soluble Fas ligand	3R01CA090691-01S1	11
2001	Functions of Transmembrane and Soluble Fas ligand	1R01CA090691-01	11
2001	RESEARCH TRAINING IN IMMUNOLOGY	5T32AI007309-14	73
2001	B CELL HYPERACTIVITY IN AUTOIMMUNITY	2R01AR035230-14A1	46
2000	CORE--ANIMAL FACILITY	5U19AI041994-04-9001	15
2000	DISTINCT EFFECTS OF TRANSMEMBRANE AND SOLUBLE FAS LIGAND	5R21GM058724-02	8
2000	RESEARCH TRAINING IN IMMUNOLOGY	5T32AI007309-13	73
2000	B CELL HYPERACTIVITY IN AUTOIMMUNITY	3R01AR035230-13S1	46
1999	CORE--ANIMAL FACILITY	5U19AI041994-03-9001	15
1999	DISTINCT EFFECTS OF TRANSMEMBRANE AND SOLUBLE FAS LIGAND	1R21GM058724-01	8
1999	RESEARCH TRAINING IN IMMUNOLOGY	5T32AI007309-12	73
1999	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-13	46
1998	CORE--ANIMAL FACILITY	5U19AI041994-02-9001	15
1998	RESEARCH TRAINING IN IMMUNOLOGY	2T32AI007309-11	73
1998	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-12	46
1997	CORE--ANIMAL FACILITY	1U19AI041994-01-9001	15
1997	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-11	46
1996	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-10	46
1995	B CELL HYPERACTIVITY IN AUTOIMMUNITY	2R01AR035230-09A1	46
1993	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-08	46
1992	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-07	46
1991	ANALYSIS OF IMMUNOREGULATORY DEFECT IN MRL/LPR MICE	5K04AR001684-05	6
1991	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-06	46
1990	ANALYSIS OF IMMUNOREGULATORY DEFECT IN MRL/LPR MICE	5K04AR001684-04	6
1990	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-05	46
1989	FLOW CYTOMETER	1S10RR004901-01
1989	AUTOIMMUNE MICE, ENGRAFTMENT BY NORMAL STEM CELLS	5R01AI024617-03	4
1989	ANALYSIS OF IMMUNOREGULATORY DEFECT IN MRL/LPR MICE	5K04AR001684-03	6
1989	B CELL HYPERACTIVITY IN AUTOIMMUNITY	2R01AR035230-04	46
1988	AUTOIMMUNE MICE, ENGRAFTMENT BY NORMAL STEM CELLS	5R01AI024617-02	4
1988	ANALYSIS OF IMMUNOREGULATORY DEFECT IN MRL/LPR MICE	5K04AR001684-02	6
1988	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-03	46
1987	AUTOIMMUNE MICE, ENGRAFTMENT BY NORMAL STEM CELLS	1R01AI024617-01	4
1987	ANALYSIS OF IMMUNOREGULATORY DEFECT IN MRL/LPR MICE	1K04AR001684-01	6
1987	B CELL HYPERACTIVITY IN AUTOIMMUNITY	5R01AR035230-02	46
1986	B CELL HYPERACTIVITY IN AUTOIMMUNITY	1R01AR035230-01A1	46
1985	REGULATION OF B CELL GROWTH BY ANTI-IDIOTYPE ANTIBODIES	5R01AI019892-03	6