Keywords
Last Name

Ann Marshak-Rothstein, PhD

TitleAdjunct Professor
InstitutionBoston University School of Medicine
DepartmentMicrobiology
 Research Expertise & Professional Interests
My laboratory is primarily interested in factors regulating T and B lymphocyte activation, function, longevity, and apoptosis, especially in animal models of systemic autoimmune disease. Particular attention has focused on the kinds of antigen that can activate potentially autoreactive B cells. Previous studies have shown that relatively low affinity autoreactive B cells can be very efficiently activated by autoantigens that have the capacity to engage both the B cell receptor and either Toll-like receptor 9 (TLR9) or TLR7. These antigens include natural chromatin, defined dsDNA fragments, and RNA-associated macromolecular complexes. Studies are underway to: (a) further characterize the nature of the autoantigens that fit this criteria; (b) compare gene expression profiles of B cells activated by either conventional foreign ligands or autoantigens; (c) evaluate the early signaling events that distinguish activation by autoantigens from activation by conventional foreign antigens; (d) compare the functional properties of B cells activated by BCR/TLR9 or BCR/TLR7 co-engagement; and (e) identify specific inhibitors of the TLR9/7 activation pathways.

A second major interest involves the regulatory functions of Fas-ligand. Fas-ligand was originally identified as a pro-apoptotic transmembrane protein critically involved in the regulation of T cells by activation induced cell death. However, under certain conditions, Fas-ligand can also induce a strong pro-inflammatory response. Fas-ligand can be cleaved by a membrane metalloproteinase to yield a soluble product that had been reported to serve as a neutrophil chemokine. However, we have found that transmembrane Fas-ligand is the most potent pro-inflammatory form of the molecule and that it can trigger the rapid expression and release of a number of inflammatory chemokines. Studies are underway to: (a) evaluate the role of Fas/FasL interactions on T cell persistence in vivo; (b) explore the mechanisms by which Fas-deficient tumor specific T cells can mediate tumor regression; (c) develop the technology to specifically target naturally formed FasL microvesicles to tumor populations; (d) distinguish the Fas signaling cascades that trigger apoptosis as opposed to inflammatory cytokine release; and (e) determine the functional phenotype of mice genetically targeted to express only a membrane form of Fas-ligand.

A third topic of investigation involves animal models of pseudo-GVHD in which TCR transgenic T cells are specifically targeted to either MHC class II+ cells or to the vascular endothelium. The model is designed such that target antigen expression can be turned on or off to allow for the evaluation of antigen-dependent and antigen-independent pathologies.

 NIH RePORTER Grants
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Krishnan A, Fei F, Jones A, Busto P, Marshak-Rothstein A, Ksander BR, Gregory-Ksander M. Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma. J Immunol. 2016 Dec 15; 197(12):4626-4638. PMID: 27849168.
    View in: PubMed
  2. Baum R, Sharma S, Organ JM, Jakobs C, Hornung V, Burr DB, Marshak-Rothstein A, Fitzgerald KA, Gravallese EM. STING regulates abnormal bone formation induced by deficiency of DNase II. Arthritis Rheumatol. 2016 Oct 14. PMID: 27740718.
    View in: PubMed
  3. Pawaria S, Sharma S, Baum R, Nündel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent? J Leukoc Biol. 2017 Jan; 101(1):121-126. PMID: 27531928.
    View in: PubMed
  4. Bossaller L, Christ A, Pelka K, Nündel K, Chiang PI, Pang C, Mishra N, Busto P, Bonegio RG, Schmidt RE, Latz E, Marshak-Rothstein A. TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus. J Immunol. 2016 Aug 15; 197(4):1044-53. PMID: 27354219.
    View in: PubMed
  5. Baum R, Nündel K, Pawaria S, Sharma S, Busto P, Fitzgerald KA, Gravallese EM, Marshak-Rothstein A. Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice. J Immunol. 2016 Feb 1; 196(3):1348-54. PMID: 26729810.
    View in: PubMed
  6. Marshak-Rothstein A. Autoimmunity--promoting and stabilizing innate immunity 'UNWUCHT'. Immunol Rev. 2016 Jan; 269(1):7-10. PMID: 26683141.
    View in: PubMed
  7. Moody KL, Uccellini MB, Avalos AM, Marshak-Rothstein A, Viglianti GA. Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells. Methods Mol Biol. 2016; 1390:249-72. PMID: 26803634.
    View in: PubMed
  8. Matsumoto H, Murakami Y, Kataoka K, Notomi S, Mantopoulos D, Trichonas G, Miller JW, Gregory MS, Ksander BR, Marshak-Rothstein A, Vavvas DG. Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium. Cell Death Dis. 2015; 6:e1986. PMID: 26583327.
    View in: PubMed
  9. Brodeur TY, Robidoux TE, Weinstein JS, Craft J, Swain SL, Marshak-Rothstein A. IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells. J Immunol. 2015 Dec 1; 195(11):5251-60. PMID: 26519529.
    View in: PubMed
  10. Sharma S, Fitzgerald KA, Cancro MP, Marshak-Rothstein A. Nucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation. J Immunol. 2015 Oct 15; 195(8):3507-12. PMID: 26432899.
    View in: PubMed
  11. Pawaria S, Moody KL, Busto P, Nündel K, Baum R, Sharma S, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S70-3. PMID: 26457825.
    View in: PubMed
  12. Nündel K, Green NM, Shaffer AL, Moody KL, Busto P, Eilat D, Miyake K, Oropallo MA, Cancro MP, Marshak-Rothstein A. Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses. J Immunol. 2015 Mar 15; 194(6):2504-12. PMID: 25681333.
    View in: PubMed
  13. Sharma S, Campbell AM, Chan J, Schattgen SA, Orlowski GM, Nayar R, Huyler AH, Nündel K, Mohan C, Berg LJ, Shlomchik MJ, Marshak-Rothstein A, Fitzgerald KA. Suppression of systemic autoimmunity by the innate immune adaptor STING. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E710-7. PMID: 25646421.
    View in: PubMed
  14. Pawaria S, Moody K, Busto P, Nündel K, Choi CH, Ghayur T, Marshak-Rothstein A. Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands. J Immunol. 2015 Feb 15; 194(4):1403-7. PMID: 25601924.
    View in: PubMed
  15. Baum R, Sharma S, Carpenter S, Li QZ, Busto P, Fitzgerald KA, Marshak-Rothstein A, Gravallese EM. Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice. J Immunol. 2015 Feb 1; 194(3):873-7. PMID: 25548216.
    View in: PubMed
  16. Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid-Burgk JL, Schmidt T, Spille JH, Labzin LI, Agrawal S, Kandimalla ER, Casanova JL, Hornung V, Marshak-Rothstein A, Höning S, Latz E. Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms. J Immunol. 2014 Oct 1; 193(7):3257-61. PMID: 25187660.
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  17. Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nat Immunol. 2014 Aug; 15(8):727-37. PMID: 24952505.
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  18. Schmidt-Lauber C, Bossaller L, Abujudeh HH, Vladimer GI, Christ A, Fitzgerald KA, Latz E, Gravallese EM, Marshak-Rothstein A, Kay J. Gadolinium-based compounds induce NLRP3-dependent IL-1ß production and peritoneal inflammation. Ann Rheum Dis. 2015 Nov; 74(11):2062-9. PMID: 24914072.
    View in: PubMed
  19. Gratz IK, Rosenblum MD, Maurano MM, Paw JS, Truong HA, Marshak-Rothstein A, Abbas AK. Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues. J Immunol. 2014 Feb 15; 192(4):1351-5. PMID: 24442443.
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  20. Lehuen A, Marshak-Rothstein A. Organ-specific and systemic autoimmune diseases. Curr Opin Immunol. 2013 Dec; 25(6):667-9. PMID: 24246387.
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  21. Bossaller L, Rathinam VA, Bonegio R, Chiang PI, Busto P, Wespiser AR, Caffrey DR, Li QZ, Mohan C, Fitzgerald KA, Latz E, Marshak-Rothstein A. Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus. J Immunol. 2013 Sep 1; 191(5):2104-14. PMID: 23918976.
    View in: PubMed
  22. Nündel K, Busto P, Debatis M, Marshak-Rothstein A. The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells. J Leukoc Biol. 2013 Nov; 94(5):865-75. PMID: 23804807.
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  23. Yasuda K, Nündel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR. Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int Immunol. 2013 May; 25(5):295-306. PMID: 23291967.
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  24. Bossaller L, Chiang PI, Schmidt-Lauber C, Ganesan S, Kaiser WJ, Rathinam VA, Mocarski ES, Subramanian D, Green DR, Silverman N, Fitzgerald KA, Marshak-Rothstein A, Latz E. Cutting edge: FAS (CD95) mediates noncanonical IL-1ß and IL-18 maturation via caspase-8 in an RIP3-independent manner. J Immunol. 2012 Dec 15; 189(12):5508-12. PMID: 23144495.
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  25. Vas J, Grönwall C, Marshak-Rothstein A, Silverman GJ. Natural antibody to apoptotic cell membranes inhibits the proinflammatory properties of lupus autoantibody immune complexes. Arthritis Rheum. 2012 Oct; 64(10):3388-98. PMID: 22577035.
    View in: PubMed
  26. Green NM, Moody KS, Debatis M, Marshak-Rothstein A. Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands. J Biol Chem. 2012 Nov 16; 287(47):39789-99. PMID: 23019335.
    View in: PubMed
  27. Kiefer K, Oropallo MA, Cancro MP, Marshak-Rothstein A. Role of type I interferons in the activation of autoreactive B cells. Immunol Cell Biol. 2012 May; 90(5):498-504. PMID: 22430248.
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  28. Han H, Xu W, Headley MB, Jessup HK, Lee KS, Omori M, Comeau MR, Marshak-Rothstein A, Ziegler SF. Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma. Mucosal Immunol. 2012 May; 5(3):342-51. PMID: 22354320.
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  29. Uccellini MB, Busto P, Debatis M, Marshak-Rothstein A, Viglianti GA. Selective binding of anti-DNA antibodies to native dsDNA fragments of differing sequence. Immunol Lett. 2012 Mar 30; 143(1):85-91. PMID: 22285306.
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  30. Oropallo MA, Kiefer K, Marshak-Rothstein A, Cancro MP. Beyond transitional selection: New roles for BLyS in peripheral tolerance. Drug Dev Res. 2011 Dec; 72(8):779-787. PMID: 22323842.
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  31. Rosenblum MD, Gratz IK, Paw JS, Lee K, Marshak-Rothstein A, Abbas AK. Response to self antigen imprints regulatory memory in tissues. Nature. 2011 Dec 22; 480(7378):538-42. PMID: 22121024.
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  32. Harris JE, Marshak-Rothstein A. Editorial: Interfering with B cell immunity. J Leukoc Biol. 2011 Jun; 89(6):805-6. PMID: 21628334.
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  33. Green NM, Marshak-Rothstein A. Toll-like receptor driven B cell activation in the induction of systemic autoimmunity. Semin Immunol. 2011 Apr; 23(2):106-12. PMID: 21306913.
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  34. Gregory MS, Hackett CG, Abernathy EF, Lee KS, Saff RR, Hohlbaum AM, Moody KS, Hobson MW, Jones A, Kolovou P, Karray S, Giani A, John SW, Chen DF, Marshak-Rothstein A, Ksander BR. Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death. PLoS One. 2011; 6(3):e17659. PMID: 21479271.
    View in: PubMed
  35. Avalos AM, Uccellini MB, Lenert P, Viglianti GA, Marshak-Rothstein A. Fc?RIIB regulation of BCR/TLR-dependent autoreactive B-cell responses. Eur J Immunol. 2010 Oct; 40(10):2692-8. PMID: 20809520.
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  36. Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE. G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity. J Exp Med. 2010 Aug 2; 207(8):1775-89. PMID: 20624888.
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  37. Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, Rifkin IR, Marshak-Rothstein A, Radstake TR, Lafyatis R. Poly(I:C) drives type I IFN- and TGFß-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol. 2010 Nov; 130(11):2583-93. PMID: 20613770.
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  38. Schoenberger SP, Cheroutre H, Uittenbogaart C, Marshak-Rothstein A. The 2010 Midwinter Conference of Immunologists at Asilomar. Nat Immunol. 2010 May; 11(5):359-61. PMID: 20404845.
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  39. Avalos AM, Busconi L, Marshak-Rothstein A. Regulation of autoreactive B cell responses to endogenous TLR ligands. Autoimmunity. 2010 Feb; 43(1):76-83. PMID: 20014959.
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  40. Avalos AM, Kiefer K, Tian J, Christensen S, Shlomchik M, Coyle AJ, Marshak-Rothstein A. RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity. 2010 Feb; 43(1):103-10. PMID: 20014975.
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  41. Richez C, Yasuda K, Bonegio RG, Watkins AA, Aprahamian T, Busto P, Richards RJ, Liu CL, Cheung R, Utz PJ, Marshak-Rothstein A, Rifkin IR. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol. 2010 Jan 15; 184(2):796-806. PMID: 20007534.
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  42. Avalos AM, Latz E, Mousseau B, Christensen SR, Shlomchik MJ, Lund F, Marshak-Rothstein A. Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides. J Immunol. 2009 Nov 15; 183(10):6262-8. PMID: 19864612.
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  43. Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol. 2009 Sep 1; 183(5):3109-17. PMID: 19648272.
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  44. Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 1; 183(3):1569-76. PMID: 19587008.
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  45. Lenert P, Yasuda K, Busconi L, Nelson P, Fleenor C, Ratnabalasuriar RS, Nagy PL, Ashman RF, Rifkin IR, Marshak-Rothstein A. DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo. Arthritis Res Ther. 2009; 11(3):R79. PMID: 19476613.
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  46. Uccellini MB, Avalos AM, Marshak-Rothstein A, Viglianti GA. Toll-like receptor-dependent immune complex activation of B cells and dendritic cells. Methods Mol Biol. 2009; 517:363-80. PMID: 19378022.
    View in: PubMed
  47. Uccellini MB, Busconi L, Green NM, Busto P, Christensen SR, Shlomchik MJ, Marshak-Rothstein A, Viglianti GA. Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha. J Immunol. 2008 Nov 1; 181(9):5875-84. PMID: 18941176.
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  48. Gregory MS, Saff RR, Marshak-Rothstein A, Ksander BR. Control of ocular tumor growth and metastatic spread by soluble and membrane Fas ligand. Cancer Res. 2007 Dec 15; 67(24):11951-8. PMID: 18089826.
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  49. Busconi L, Bauer JW, Tumang JR, Laws A, Perkins-Mesires K, Tabor AS, Lau C, Corley RB, Rothstein TL, Lund FE, Behrens TW, Marshak-Rothstein A. Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9. J Immunol. 2007 Dec 1; 179(11):7397-405. PMID: 18025183.
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  50. Marshak-Rothstein A, Ohashi PS. Intricate connections between innate and adaptive autoimmunity. Curr Opin Immunol. 2007 Dec; 19(6):603-5. PMID: 18083508.
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  51. Yasuda K, Richez C, Maciaszek JW, Agrawal N, Akira S, Marshak-Rothstein A, Rifkin IR. Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. J Immunol. 2007 Jun 1; 178(11):6876-85. PMID: 17513736.
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  52. Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, Parroche P, Drabic S, Golenbock D, Sirois C, Hua J, An LL, Audoly L, La Rosa G, Bierhaus A, Naworth P, Marshak-Rothstein A, Crow MK, Fitzgerald KA, Latz E, Kiener PA, Coyle AJ. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol. 2007 May; 8(5):487-96. PMID: 17417641.
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  53. Lafyatis R, Marshak-Rothstein A. Toll-like receptors and innate immune responses in systemic lupus erythematosus. Arthritis Res Ther. 2007; 9(6):222. PMID: 18086320.
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  54. Marshak-Rothstein A, Rifkin IR. Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol. 2007; 25:419-41. PMID: 17378763.
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  55. Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol. 2006 Nov; 6(11):823-35. PMID: 17063184.
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  56. Lafyatis R, York M, Marshak-Rothstein A. Antimalarial agents: closing the gate on Toll-like receptors? Arthritis Rheum. 2006 Oct; 54(10):3068-70. PMID: 17009223.
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  57. Marshak-Rothstein A. Tolling for autoimmunity-prime time for 7. Immunity. 2006 Sep; 25(3):397-9. PMID: 16979573.
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  58. Beaudette-Zlatanova BC, Ling T, Shlomchik MJ, Marshak-Rothstein A, Rifkin IR. B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells. J Immunol. 2006 Jul 1; 177(1):45-52. PMID: 16785497.
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  59. Busconi L, Lau CM, Tabor AS, Uccellini MB, Ruhe Z, Akira S, Viglianti GA, Rifkin IR, Marshak-Rothstein A. DNA and RNA autoantigens as autoadjuvants. J Endotoxin Res. 2006; 12(6):379-84. PMID: 17254393.
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  60. Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med. 2005 Nov 7; 202(9):1171-7. PMID: 16260486.
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  61. Gregory MS, Koh S, Huang E, Saff RR, Marshak-Rothstein A, Mukai S, Ksander BR. A novel treatment for ocular tumors using membrane FasL vesicles to activate innate immunity and terminate immune privilege. Invest Ophthalmol Vis Sci. 2005 Jul; 46(7):2495-502. PMID: 15980241.
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  62. William J, Euler C, Leadbetter E, Marshak-Rothstein A, Shlomchik MJ. Visualizing the onset and evolution of an autoantibody response in systemic autoimmunity. J Immunol. 2005 Jun 1; 174(11):6872-8. PMID: 15905529.
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  63. Rifkin IR, Leadbetter EA, Busconi L, Viglianti G, Marshak-Rothstein A. Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol Rev. 2005 Apr; 204:27-42. PMID: 15790348.
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  64. Funatake CJ, Dearstyne EA, Steppan LB, Shepherd DM, Spanjaard ES, Marshak-Rothstein A, Kerkvliet NI. Early consequences of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on the activation and survival of antigen-specific T cells. Toxicol Sci. 2004 Nov; 82(1):129-42. PMID: 15310856.
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  65. Marshak-Rothstein A, Busconi L, Rifkin IR, Viglianti GA. The stimulation of Toll-like receptors by nuclear antigens: a link between apoptosis and autoimmunity. Rheum Dis Clin North Am. 2004 Aug; 30(3):559-74, ix. PMID: 15261341.
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  66. Boulé MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med. 2004 Jun 21; 199(12):1631-40. PMID: 15197227.
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  67. Saff RR, Spanjaard ES, Hohlbaum AM, Marshak-Rothstein A. Activation-induced cell death limits effector function of CD4 tumor-specific T cells. J Immunol. 2004 Jun 1; 172(11):6598-606. PMID: 15153474.
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  68. Xiao S, Zhang X, Mann KK, Jodo S, Li L, Jarjour WN, Marshak-Rothstein A, Sherr DH, Ju ST. Changes in sensitivity of peripheral lymphocytes of autoimmune gld mice to FasL-mediated apoptosis reveal a mechanism for the preferential deletion of CD4-CD8-B220+ T cells. Int Immunol. 2004 May; 16(5):759-66. PMID: 15096479.
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  69. Marshak-Rothstein A, Busconi L, Lau CM, Tabor AS, Leadbetter EA, Akira S, Krieg AM, Lipford GB, Viglianti GA, Rifkin IR. Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells. J Endotoxin Res. 2004; 10(4):247-51. PMID: 15373969.
    View in: PubMed
  70. Viglianti GA, Lau CM, Hanley TM, Miko BA, Shlomchik MJ, Marshak-Rothstein A. Activation of autoreactive B cells by CpG dsDNA. Immunity. 2003 Dec; 19(6):837-47. PMID: 14670301.
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  71. Rifkin IR, Marshak-Rothstein A. T-bet: the Toll-bridge to class-switch recombination? Nat Immunol. 2003 Jul; 4(7):650-2. PMID: 12830144.
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  72. Leadbetter EA, Rifkin IR, Marshak-Rothstein A. Toll-like receptors and activation of autoreactive B cells. Curr Dir Autoimmun. 2003; 6:105-22. PMID: 12408049.
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  73. Xiao S, Jodo S, Sung SS, Marshak-Rothstein A, Ju ST. A novel signaling mechanism for soluble CD95 ligand. Synergy with anti-CD95 monoclonal antibodies for apoptosis and NF-kappaB nuclear translocation. J Biol Chem. 2002 Dec 27; 277(52):50907-13. PMID: 12393889.
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  74. Gregory MS, Repp AC, Holhbaum AM, Saff RR, Marshak-Rothstein A, Ksander BR. Membrane Fas ligand activates innate immunity and terminates ocular immune privilege. J Immunol. 2002 Sep 1; 169(5):2727-35. PMID: 12193747.
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  75. Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 2002 Apr 11; 416(6881):603-7. PMID: 11948342.
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  76. Hohlbaum AM, Saff RR, Marshak-Rothstein A. Fas-ligand--iron fist or Achilles' heel? Clin Immunol. 2002 Apr; 103(1):1-6. PMID: 11987979.
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  77. Hohlbaum AM, Gregory MS, Ju ST, Marshak-Rothstein A. Fas ligand engagement of resident peritoneal macrophages in vivo induces apoptosis and the production of neutrophil chemotactic factors. J Immunol. 2001 Dec 1; 167(11):6217-24. PMID: 11714783.
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  78. Xiao S, Marshak-Rothstein A, Ju ST. Sp1 is the major fasl gene activator in abnormal CD4(-)CD8(-)B220(+) T cells of lpr and gld mice. Eur J Immunol. 2001 Nov; 31(11):3339-48. PMID: 11745351.
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  79. Jodo S, Xiao S, Hohlbaum A, Strehlow D, Marshak-Rothstein A, Ju ST. Apoptosis-inducing membrane vesicles. A novel agent with unique properties. J Biol Chem. 2001 Oct 26; 276(43):39938-44. PMID: 11546786.
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  80. Jodo S, Hohlbaum AM, Xiao S, Chan D, Strehlow D, Sherr DH, Marshak-Rothstein A, Ju ST. CD95 (Fas) ligand-expressing vesicles display antibody-mediated, FcR-dependent enhancement of cytotoxicity. J Immunol. 2000 Nov 15; 165(10):5487-94. PMID: 11067901.
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  81. Rifkin IR, Leadbetter EA, Beaudette BC, Kiani C, Monestier M, Shlomchik MJ, Marshak-Rothstein A. Immune complexes present in the sera of autoimmune mice activate rheumatoid factor B cells. J Immunol. 2000 Aug 1; 165(3):1626-33. PMID: 10903773.
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  82. Zhu B, Beaudette BC, Rifkin IR, Marshak-Rothstein A. Double mutant MRL-lpr/lpr-gld/gld cells fail to trigger lpr-graft-versus-host disease in syngeneic wild-type recipient mice, but can induce wild-type B cells to make autoantibody. Eur J Immunol. 2000 Jun; 30(6):1778-84. PMID: 10898516.
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  83. Gochuico BR, Zhang J, Ma BY, Marshak-Rothstein A, Fine A. TRAIL expression in vascular smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2000 May; 278(5):L1045-50. PMID: 10781437.
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  84. Hohlbaum AM, Moe S, Marshak-Rothstein A. Opposing effects of transmembrane and soluble Fas ligand expression on inflammation and tumor cell survival. J Exp Med. 2000 Apr 3; 191(7):1209-20. PMID: 10748238.
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  85. Wang JK, Ju ST, Marshak-Rothstein A. Protection of T cells from activation-induced cell death by Fas+ B cells. Eur J Immunol. 2000 Mar; 30(3):931-7. PMID: 10741411.
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  86. Boes M, Schmidt T, Linkemann K, Beaudette BC, Marshak-Rothstein A, Chen J. Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM. Proc Natl Acad Sci U S A. 2000 Feb 1; 97(3):1184-9. PMID: 10655505.
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  87. Xiao S, Matsui K, Fine A, Zhu B, Marshak-Rothstein A, Widom RL, Ju ST. FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3. Eur J Immunol. 1999 Nov; 29(11):3456-65. PMID: 10556800.
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  88. Zhang J, Ma B, Marshak-Rothstein A, Fine A. Characterization of a novel cis-element that regulates Fas ligand expression in corneal endothelial cells. J Biol Chem. 1999 Sep 10; 274(37):26537-42. PMID: 10473616.
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  89. Rifkin IR, Marshak-Rothstein A. Fas and Fas ligand in autoimmunity. Curr Dir Autoimmun. 1999; 1:31-55. PMID: 11791447.
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  90. Morgan G, Smith S, Pak J, Marshak-Rothstein A, Fissore R, Osborne B. Characterization of a mutant T-cell hybridoma line with defects in the TCR-mediated apoptotic pathway. Cell Death Differ. 1999 Jan; 6(1):36-47. PMID: 10200546.
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  91. Rifkin IR, Channavajhala PL, Kiefer HL, Carmack AJ, Landesman-Bollag E, Beaudette BC, Jersky B, Salant DJ, Ju ST, Marshak-Rothstein A, Seldin DC. Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15; 161(10):5164-70. PMID: 9820486.
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  92. Matsui K, Fine A, Zhu B, Marshak-Rothstein A, Ju ST. Identification of two NF-kappa B sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma. J Immunol. 1998 Oct 1; 161(7):3469-73. PMID: 9759866.
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  93. Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, Torres Arzayus MI, Priestley A, Jackson SP, Marshak Rothstein A, Jeggo PA, Herrera VL. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity. 1998 Sep; 9(3):355-66. PMID: 9768755.
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  94. Foote LC, Marshak-Rothstein A, Rothstein TL. Tolerant B lymphocytes acquire resistance to Fas-mediated apoptosis after treatment with interleukin 4 but not after treatment with specific antigen unless a surface immunoglobulin threshold is exceeded. J Exp Med. 1998 Mar 16; 187(6):847-53. PMID: 9500787.
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  95. Wang JK, Zhu B, Ju ST, Tschopp J, Marshak-Rothstein A. CD4+ T cells reactivated with superantigen are both more sensitive to FasL-mediated killing and express a higher level of FasL. Cell Immunol. 1997 Aug 1; 179(2):153-64. PMID: 9268499.
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  96. Foote LC, Marshak-Rothstein A, Rothstein TL. Inducible Fas-resistance mediated by IL-4 in activated B cells. Ann N Y Acad Sci. 1997 Apr 5; 815:114-5. PMID: 9186645.
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  97. Jacobson BA, Foote LC, Panka DJ, Ju ST, Rothstein TL, Marshak-Rothstein A. Unique site of autoantibody production in Fas-deficient mice. Ann N Y Acad Sci. 1997 Apr 5; 815:218-29. PMID: 9186658.
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  98. Jacobson BA, Rothstein TL, Marshak-Rothstein A. Unique site of IgG2a and rheumatoid factor production in MRL/lpr mice. Immunol Rev. 1997 Apr; 156:103-10. PMID: 9176703.
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  99. Elkon KB, Marshak-Rothstein A. B cells in systemic autoimmune disease: recent insights from Fas-deficient mice and men. Curr Opin Immunol. 1996 Dec; 8(6):852-9. PMID: 8994866.
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  100. Jacobson BA, Rothstein TL, Marshak-Rothstein A. The role of Fas/FasL interactions in the regulation of B cell function. Behring Inst Mitt. 1996 Oct; (97):185-99. PMID: 8950476.
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  101. Foote LC, Howard RG, Marshak-Rothstein A, Rothstein TL. IL-4 induces Fas resistance in B cells. J Immunol. 1996 Oct 1; 157(7):2749-53. PMID: 8816375.
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  102. Foote LC, Schneider TJ, Fischer GM, Wang JK, Rasmussen B, Campbell KA, Lynch DH, Ju ST, Marshak-Rothstein A, Rothstein TL. Intracellular signaling for inducible antigen receptor-mediated Fas resistance in B cells. J Immunol. 1996 Sep 1; 157(5):1878-85. PMID: 8757305.
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  103. Perkins DL, Listman JA, Marshak-Rothstein A, Kozlow W, Kelley VR, Finn PW, Rimm IJ. Restriction of the TCR repertoire inhibits the development of memory T cells and prevents autoimmunity in lpr mice. J Immunol. 1996 Jun 15; 156(12):4961-8. PMID: 8648148.
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  104. Christianson GJ, Blankenburg RL, Duffy TM, Panka D, Roths JB, Marshak-Rothstein A, Roopenian DC. beta2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice. J Immunol. 1996 Jun 15; 156(12):4932-9. PMID: 8648144.
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  105. Ozdemirli M, El-Khatib M, Foote LC, Wang JK, Marshak-Rothstein A, Rothstein TL, Ju ST. Fas (CD95)/Fas ligand interactions regulate antigen-specific, major histocompatibility complex-restricted T/B cell proliferative responses. Eur J Immunol. 1996 Feb; 26(2):415-9. PMID: 8617312.
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  106. Cui H, el-Khatib M, Sherr DH, Ettinger R, Sy MS, Marshak-Rothstein A, Ju ST. Characterization of lpr-derived T cell hybridomas: Fas-deficient hybridomas are deathless, growth-arrested, and cytotoxic upon activation. Cell Immunol. 1996 Feb 1; 167(2):302-12. PMID: 8603440.
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  107. Cui H, Sherr DH, el-Khatib M, Matsui K, Panka DJ, Marshak-Rothstein A, Ju ST. Regulation of T-cell death genes: selective inhibition of FasL- but not Fas-mediated function. Cell Immunol. 1996 Feb 1; 167(2):276-84. PMID: 8603437.
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  108. Rothstein TL, Foote LC, Schneider TJ, Fischer GM, Jacobson BA, Lynch DH, Ju ST, Marshak-Rothstein A. Inducible resistance to Fas-mediated apoptosis in primary B lymphocytes. Adv Exp Med Biol. 1996; 406:177-89. PMID: 8910684.
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  109. Jacobson BA, Panka DJ, Nguyen KA, Erikson J, Abbas AK, Marshak-Rothstein A. Anatomy of autoantibody production: dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice. Immunity. 1995 Oct; 3(4):509-19. PMID: 7584141.
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  110. Israel EJ, Patel VK, Taylor SF, Marshak-Rothstein A, Simister NE. Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. J Immunol. 1995 Jun 15; 154(12):6246-51. PMID: 7759862.
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  111. Ettinger R, Panka DJ, Wang JK, Stanger BZ, Ju ST, Marshak-Rothstein A. Fas ligand-mediated cytotoxicity is directly responsible for apoptosis of normal CD4+ T cells responding to a bacterial superantigen. J Immunol. 1995 May 1; 154(9):4302-8. PMID: 7536768.
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  112. Rothstein TL, Wang JK, Panka DJ, Foote LC, Wang Z, Stanger B, Cui H, Ju ST, Marshak-Rothstein A. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature. 1995 Mar 9; 374(6518):163-5. PMID: 7533263.
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  113. Ju ST, Panka DJ, Cui H, Ettinger R, el-Khatib M, Sherr DH, Stanger BZ, Marshak-Rothstein A. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature. 1995 Feb 2; 373(6513):444-8. PMID: 7530337.
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  114. Panka DJ, Salant DJ, Jacobson BA, Minto AW, Marshak-Rothstein A. The effect of VH residues 6 and 23 on IgG3 cryoprecipitation and glomerular deposition. Eur J Immunol. 1995 Jan; 25(1):279-84. PMID: 7843244.
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  115. Singer GG, Carrera AC, Marshak-Rothstein A, Martínez C, Abbas AK. Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model. Curr Opin Immunol. 1994 Dec; 6(6):913-20. PMID: 7536012.
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  116. Shan H, Shlomchik MJ, Marshak-Rothstein A, Pisetsky DS, Litwin S, Weigert MG. The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. J Immunol. 1994 Dec 1; 153(11):5104-20. PMID: 7525723.
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  117. Ju ST, Cui H, Panka DJ, Ettinger R, Marshak-Rothstein A. Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4185-9. PMID: 7514297.
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  118. Jacobson BA, Sharon J, Shan H, Shlomchik M, Weigert MG, Marshak-Rothstein A. An isotype switched and somatically mutated rheumatoid factor clone isolated from a MRL-lpr/lpr mouse exhibits limited intraclonal affinity maturation. J Immunol. 1994 May 1; 152(9):4489-99. PMID: 8157964.
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  119. Ettinger R, Wang JK, Bossu P, Papas K, Sidman CL, Abbas AK, Marshak-Rothstein A. Functional distinctions between MRL-lpr and MRL-gld lymphocytes. Normal cells reverse the gld but not lpr immunoregulatory defect. J Immunol. 1994 Feb 15; 152(4):1557-68. PMID: 8120369.
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  120. Bossu P, Singer GG, Andres P, Ettinger R, Marshak-Rothstein A, Abbas AK. Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. J Immunol. 1993 Dec 15; 151(12):7233-9. PMID: 7903104.
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  121. Very DL, Panka DJ, Weissman D, Wysocki L, Manser T, Marshak-Rothstein A. Lack of connectivity between the induced and autoimmune repertoires of lpr/lpr mice. Immunology. 1993 Dec; 80(4):518-26. PMID: 8307604.
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  122. Levine JS, Pugh BJ, Hartwell D, Fitzpatrick JM, Marshak-Rothstein A, Beller DI. Interleukin-1 dysregulation is an intrinsic defect in macrophages from MRL autoimmune-prone mice. Eur J Immunol. 1993 Nov; 23(11):2951-8. PMID: 8223873.
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  123. Panka DJ, Very DL, Jacobson BA, Kussie PH, Parhami-Seren B, Margolies MN, Marshak-Rothstein A. Defining the structural correlates responsible for loss of arsonate affinity in an IDCR antibody isolated from an autoimmune mouse. Mol Immunol. 1993 Aug; 30(11):1013-20. PMID: 8350871.
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  124. Glaser RM, Mahon CA, Marshak-Rothstein A. Persistence of lpr/lpr-derived IgG2a secreting B cells in normal----lpr/lpr adult radiation chimeras or lpr/lpr----normal kidney capsule chimeras. Cell Immunol. 1992 Jul; 142(2):313-25. PMID: 1623555.
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  125. Berney T, Fulpius T, Shibata T, Reininger L, Van Snick J, Shan H, Weigert M, Marshak-Rothstein A, Izui S. Selective pathogenicity of murine rheumatoid factors of the cryoprecipitable IgG3 subclass. Int Immunol. 1992 Jan; 4(1):93-9. PMID: 1540551.
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  126. Nemazee D, Guiet C, Buerki K, Marshak-Rothstein A. B lymphocytes from the autoimmune-prone mouse strain MLR/lpr manifest an intrinsic defect in tetraparental MRL/lpr in equilibrium DBA/2 chimeras. J Immunol. 1991 Oct 15; 147(8):2536-9. PMID: 1918976.
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  127. Glaser RM, Marshak-Rothstein A. Resistance to lymphoid engraftment in lpr recipients of normal bone marrow: characterization of chimeric stem cell, monocyte and peripheral lymphoid lineages. Eur J Immunol. 1990 Sep; 20(9):1917-25. PMID: 2209698.
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  128. Perkins DL, Glaser RM, Mahon CA, Michaelson J, Marshak-Rothstein A. Evidence for an intrinsic B cell defect in lpr/lpr mice apparent in neonatal chimeras. J Immunol. 1990 Jul 15; 145(2):549-55. PMID: 2365994.
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  129. Traish AM, Ettinger R, Kim N, Marshak-Rothstein A, Wotiz HH. Development and characterization of monoclonal antibodies to a specific domain of human estrogen receptor. Steroids. 1990 May; 55(5):196-208. PMID: 2360217.
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  130. Shlomchik M, Mascelli M, Shan H, Radic MZ, Pisetsky D, Marshak-Rothstein A, Weigert M. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med. 1990 Jan 1; 171(1):265-92. PMID: 2104919.
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  131. Wolfowicz CB, Lyons S, Mahon CA, Marshak-Rothstein A, Rothstein TL. Isolation of self-recognizing IgG2a monoclonal rheumatoid factors. Clin Immunol Immunopathol. 1989 Aug; 52(2):313-22. PMID: 2736811.
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  132. Yamada K, Spezialetti R, Marshak-Rothstein A, Sy MS. Autoantibody in MRL/Mp-lpr/lpr mice. A monoclonal antibody specific for the abnormal T cells from mice bearing the lpr/lpr gene. J Immunol. 1989 Apr 15; 142(8):2702-7. PMID: 2649559.
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  133. Marshak-Rothstein A. Origins of autoantibodies. Curr Opin Immunol. 1989 Apr; 1(4):697-700. PMID: 2679722.
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  134. Bonfa E, Marshak-Rothstein A, Weissbach H, Brot N, Elkon K. Frequency and epitope recognition of anti-ribosome P antibodies from humans with systemic lupus erythematosus and MRL/lpr mice are similar. J Immunol. 1988 May 15; 140(10):3434-7. PMID: 2452189.
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  135. Wolfowicz CB, Sakorafas P, Rothstein TL, Marshak-Rothstein A. Oligoclonality of rheumatoid factors arising spontaneously in lpr/lpr mice. Clin Immunol Immunopathol. 1988 Mar; 46(3):382-95. PMID: 3338196.
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  136. Perkins DL, Michaelson J, Glaser RM, Marshak-Rothstein A. Selective elimination of non-lpr lymphoid cells in mice undergoing lpr-mediated graft-vs-host disease. J Immunol. 1987 Sep 1; 139(5):1406-13. PMID: 2887617.
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  137. Shlomchik MJ, Marshak-Rothstein A, Wolfowicz CB, Rothstein TL, Weigert MG. The role of clonal selection and somatic mutation in autoimmunity. Nature. 1987 Aug 27-Sep 2; 328(6133):805-11. PMID: 3498121.
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  138. Perkins DL, Michaelson J, Marshak-Rothstein A. The lpr gene is associated with resistance to engraftment by lymphoid but not erythroid stem cells from normal mice. J Immunol. 1987 Jan 15; 138(2):466-9. PMID: 2878956.
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  139. Weissman D, Parker DJ, Rothstein TL, Marshak-Rothstein A. Methods for the production of xenogeneic monoclonal antibodies in murine ascites. J Immunol. 1985 Aug; 135(2):1001-3. PMID: 4008923.
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  140. Weissman D, Rothstein TL, Marshak-Rothstein A. A rapid method for comparing monoclonal antibodies by limited proteolysis and electrophoresis. Hybridoma. 1985; 4(4):329-39. PMID: 3905580.
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  141. Groopman JD, Trudel LJ, Donahue PR, Marshak-Rothstein A, Wogan GN. High-affinity monoclonal antibodies for aflatoxins and their application to solid-phase immunoassays. Proc Natl Acad Sci U S A. 1984 Dec; 81(24):7728-31. PMID: 6440143.
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  142. McCormack JE, Pepe VH, Kent RB, Dean M, Marshak-Rothstein A, Sonenshein GE. Specific regulation of c-myc oncogene expression in a murine B-cell lymphoma. Proc Natl Acad Sci U S A. 1984 Sep; 81(17):5546-50. PMID: 6206500.
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  143. Rothstein TL, Miller RA, Parker DJ, Kelly E, Vastola AP, Marshak-Rothstein A. Induction of idiotope suppression in the anti-azophenylarsonate response of T-depleted A/J mice. J Exp Med. 1984 Apr 1; 159(4):1283-8. PMID: 6608575.
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  144. McCormack JE, Kent RB, Pepe VH, Dean M, Marshak-Rothstein A, Sonenshein GE. Immune regulation of the c-myc oncogene in a murine B lymphoma. Curr Top Microbiol Immunol. 1984; 113:127-32. PMID: 6332712.
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  145. Rothstein TL, Margolies MN, Gefter ML, Marshak-Rothstein A. Fine specificity of idiotope suppression in the A/J anti-azophenylarsonate response. J Exp Med. 1983 Feb 1; 157(2):795-800. PMID: 6185619.
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  146. Margolies MN, Juszczak EC, Near R, Marshak-Rothstein A, Rothstein TL, Sato VL, Siekevitz M, Smith JA, Wysocki LJ, Gefter ML. Structural correlates of idiotypy in the arsonate system. Ann N Y Acad Sci. 1983; 418:48-64. PMID: 6424532.
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  147. Siekevitz M, Gefter ML, Brodeur P, Riblet R, Marshak-Rothstein A. The genetic basis of antibody production: the dominant anti-arsonate idiotype response of the strain A mouse. Eur J Immunol. 1982 Dec; 12(12):1023-32. PMID: 6186498.
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  148. Margolies MN, Marshak-Rothstein A, Gefter ML. Structural diversity among anti-p-azophenylarsonate monoclonal antibodies from A/J mice; comparison of Id- and Id+ sequences. Mol Immunol. 1981 Dec; 18(12):1065-77. PMID: 6801478.
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  149. Marshak-Rothstein A, Margolies MN, Benedetto JD, Gefter ML. Two structurally distinct and independently regulated idiotypic families associated with the A/J response to azophenylarsonate. Eur J Immunol. 1981 Jul; 11(7):565-72. PMID: 7286063.
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  150. Schwartz AL, Marshak-Rothstein A, Rup D, Lodish HF. Identification and quantification of the rat hepatocyte asialoglycoprotein receptor. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3348-52. PMID: 6267585.
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  151. Marshak-Rothstein A, Benedetto JD, Kirsch RL, Gefter ML. Unique determinants associated with hybridoma proteins expressing a cross-reactive idiotype: frequency among individual immune sera. J Immunol. 1980 Nov; 125(5):1987-92. PMID: 6159397.
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  152. Marshak-Rothstein A, Siekevitz M, Margolies MN, Mudgett-Hunter M, Gefter ML. Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J mice. Proc Natl Acad Sci U S A. 1980 Feb; 77(2):1120-4. PMID: 6767242.
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  153. Gottlieb PD, Marshak-Rothstein A, Auditore-Hargreaves K, Berkoben DB, August DA, Rosche RM, Benedetto JD. Construction and properties of new Lyt-congenic strains and anti-Lyt-2.2 and anti-Lyt-3.1 monoclonal antibodies. Immunogenetics. 1980; 10(6):545-55. PMID: 22457935.
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  154. Marshak-Rothstein A, Fink P, Gridley T, Raulet DH, Bevan MJ, Gefter ML. Properties and applications of monoclonal antibodies directed against determinants of they Thy-1 locus. J Immunol. 1979 Jun; 122(6):2491-7. PMID: 87465.
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