Michael R. York, MD
|Institution||Boston University School of Medicine|
|Address||75 E. Newton St Evans Building|
Boston MA 02118
|1996||Massachusetts General Hospital:
American Liver Foundation Student Scholar|
Mark Flapan Award|
|2007||American College of Rheumatology:
ACR/REF Physician Scientist Development Award|
Young Investigator Award|
Our group is currently investigating the role of the innate immune system on the development of systemic sclerosis (scleroderma). This disease is characterized by thick skin and scarring of internal organs such as the lungs as well as vascular problems such as Raynaud’s phenomenon, pulmonary hypertension and gangrene. We are trying to determine how the immune system causes these problems and develop new therapeutics to treat this disease.
We are currently focusing on how dysfunction of the patient’s immune system occurs and how this leads to vascular and fibrotic disease. We are focusing on receptors of the innate immune system called toll-like receptors that typically recognize viral or bacterial DNA or RNA. Recently it has been found that immune complexes found in patients with Systemic Lupus Erythematosus or Scleroderma can trigger these receptors by allowing self-DNA or RNA to enter cells, thereby overcoming some of the protective mechanisms preventing the host to develop an immune response against itself.
- endothelial cells
- innate immunity
- pulmonary arterial hypertension
- systemic sclerosis
- localized scleroderma
- linear scleroderma
- en coup de sabre
- Raynaud's Disease
- Psoriatic Arthritis
- Systemic lupus erythematosus
- Digital ulcers
- interstitial lung disease
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