Keywords
Last Name

Alan Fine, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-4860
ORCID ORCID Icon0000-0001-9351-3048
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Expertise in stem cells and smooth muscle development.

 Self-Described Keywords
  • mesenchyme
  • stem cells
  • Vessels
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81.
    View in: PubMed
  2. Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin Invest. 2014 Feb 3; 124(2):801-11.
    View in: PubMed
  3. Aven L, Paez-Cortez J, Achey R, Krishnan R, Ram-Mohan S, Cruikshank WW, Fine A, Ai X. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb; 28(2):897-907.
    View in: PubMed
  4. Dixit R, Ai X, Fine A. Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry. Development. 2013 Nov; 140(21):4398-406.
    View in: PubMed
  5. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469.
    View in: PubMed
  6. Braubach OR, Miyasaka N, Koide T, Yoshihara Y, Croll RP, Fine A. Experience-dependent versus experience-independent postembryonic development of distinct groups of zebrafish olfactory glomeruli. J Neurosci. 2013 Apr 17; 33(16):6905-16.
    View in: PubMed
  7. Ohle SJ, Anandaiah A, Fabian AJ, Fine A, Kotton DN. Maintenance and repair of the lung endothelium does not involve contributions from marrow-derived endothelial precursor cells. Am J Respir Cell Mol Biol. 2012 Jul; 47(1):11-9.
    View in: PubMed
  8. Konter JM, Parker JL, Baez E, Li SZ, Ranscht B, Denzel M, Little FF, Nakamura K, Ouchi N, Fine A, Walsh K, Summer RS. Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation. J Immunol. 2012 Jan 15; 188(2):854-63.
    View in: PubMed
  9. Radzikinas K, Aven L, Jiang Z, Tran T, Paez-Cortez J, Boppidi K, Lu J, Fine A, Ai X. A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle. J Neurosci. 2011 Oct 26; 31(43):15407-15.
    View in: PubMed
  10. Ghosh S, Paez-Cortez JR, Boppidi K, Vasconcelos M, Roy M, Cardoso W, Ai X, Fine A. Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery. J Biol Chem. 2011 Jun 24; 286(25):22678-87.
    View in: PubMed
  11. Langsdorf A, Schumacher V, Shi X, Tran T, Zaia J, Jain S, Taglienti M, Kreidberg JA, Fine A, Ai X. Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche. Glycobiology. 2011 Feb; 21(2):152-61.
    View in: PubMed
  12. Kimmelman J, London AJ, Ravina B, Ramsay T, Bernstein M, Fine A, Stahnisch FW, Emborg ME. Launching invasive, first-in-human trials against Parkinson's disease: ethical considerations. Mov Disord. 2009 Oct 15; 24(13):1893-901.
    View in: PubMed
  13. Summer R, Fiack CA, Ikeda Y, Sato K, Dwyer D, Ouchi N, Fine A, Farber HW, Walsh K. Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease. Am J Physiol Lung Cell Mol Physiol. 2009 Sep; 297(3):L432-8.
    View in: PubMed
  14. Fine A. Breathing life into the lung stem cell field. Cell Stem Cell. 2009 Jun 5; 4(6):468-9.
    View in: PubMed
  15. Summer R, Fine A. Mesenchymal progenitor cell research: limitations and recommendations. Proc Am Thorac Soc. 2008 Aug 15; 5(6):707-10.
    View in: PubMed
  16. Wilson AA, Kwok LW, Hovav AH, Ohle SJ, Little FF, Fine A, Kotton DN. Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells. Am J Respir Cell Mol Biol. 2008 Aug; 39(2):133-41.
    View in: PubMed
  17. Murphy J, Summer R, Wilson AA, Kotton DN, Fine A. The prolonged life-span of alveolar macrophages. Am J Respir Cell Mol Biol. 2008 Apr; 38(4):380-5.
    View in: PubMed
  18. Murphy J, Summer R, Fine A. Stem cells in airway smooth muscle: state of the art. Proc Am Thorac Soc. 2008 Jan 1; 5(1):11-4.
    View in: PubMed
  19. Kotton DN, Fine A. Lung stem cells. Cell Tissue Res. 2008 Jan; 331(1):145-56.
    View in: PubMed
  20. Summer R, Fitzsimmons K, Dwyer D, Murphy J, Fine A. Isolation of an adult mouse lung mesenchymal progenitor cell population. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):152-9.
    View in: PubMed
  21. Wallach-Dayan SB, Izbicki G, Cohen PY, Gerstl-Golan R, Fine A, Breuer R. Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L790-L796.
    View in: PubMed
  22. Mouquet F, Pfister O, Jain M, Oikonomopoulos A, Ngoy S, Summer R, Fine A, Liao R. Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ Res. 2005 Nov 25; 97(11):1090-2.
    View in: PubMed
  23. Liang SX, Summer R, Sun X, Fine A. Gene expression profiling and localization of Hoechst-effluxing CD45- and CD45+ cells in the embryonic mouse lung. Physiol Genomics. 2005 Oct 17; 23(2):172-81.
    View in: PubMed
  24. Chang JC, Summer R, Sun X, Fitzsimmons K, Fine A. Evidence that bone marrow cells do not contribute to the alveolar epithelium. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):335-42.
    View in: PubMed
  25. Pfister O, Mouquet F, Jain M, Summer R, Helmes M, Fine A, Colucci WS, Liao R. CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ Res. 2005 Jul 8; 97(1):52-61.
    View in: PubMed
  26. Summer R, Kotton DN, Liang S, Fitzsimmons K, Sun X, Fine A. Embryonic lung side population cells are hematopoietic and vascular precursors. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):32-40.
    View in: PubMed
  27. Scimemi A, Fine A, Kullmann DM, Rusakov DA. NR2B-containing receptors mediate cross talk among hippocampal synapses. J Neurosci. 2004 May 19; 24(20):4767-77.
    View in: PubMed
  28. Reid CA, Dixon DB, Takahashi M, Bliss TV, Fine A. Optical quantal analysis indicates that long-term potentiation at single hippocampal mossy fiber synapses is expressed through increased release probability, recruitment of new release sites, and activation of silent synapses. J Neurosci. 2004 Apr 7; 24(14):3618-26.
    View in: PubMed
  29. Kotton DN, Summer R, Fine A. Lung stem cells: new paradigms. Exp Hematol. 2004 Apr; 32(4):340-3.
    View in: PubMed
  30. Summer R, Kotton DN, Sun X, Fitzsimmons K, Fine A. Translational physiology: origin and phenotype of lung side population cells. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L477-83.
    View in: PubMed
  31. Fine A. Marrow cells as progenitors of lung tissue. Blood Cells Mol Dis. 2004 Jan-Feb; 32(1):95-6.
    View in: PubMed
  32. Mogi M, Yang J, Lambert JF, Colvin GA, Shiojima I, Skurk C, Summer R, Fine A, Quesenberry PJ, Walsh K. Akt signaling regulates side population cell phenotype via Bcrp1 translocation. J Biol Chem. 2003 Oct 3; 278(40):39068-75.
    View in: PubMed
  33. Summer R, Kotton DN, Sun X, Ma B, Fitzsimmons K, Fine A. Side population cells and Bcrp1 expression in lung. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L97-104.
    View in: PubMed
  34. Kotton DN, Summer RS, Sun X, Ma BY, Fine A. Stem cell antigen-1 expression in the pulmonary vascular endothelium. Am J Physiol Lung Cell Mol Physiol. 2003 Jun; 284(6):L990-6.
    View in: PubMed
  35. Kotton DN, Fine A. Derivation of lung epithelium from bone marrow cells. Cytotherapy. 2003; 5(2):169-73.
    View in: PubMed
  36. Izbicki G, Or R, Christensen TG, Segel MJ, Fine A, Goldstein RH, Breuer R. Bleomycin-induced lung fibrosis in IL-4-overexpressing and knockout mice. Am J Physiol Lung Cell Mol Physiol. 2002 Nov; 283(5):L1110-6.
    View in: PubMed
  37. Kotton DN, Ma BY, Cardoso WV, Sanderson EA, Summer RS, Williams MC, Fine A. Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development. 2001 Dec; 128(24):5181-8.
    View in: PubMed
  38. Fine A, Janssen-Heininger Y, Soultanakis RP, Swisher SG, Uhal BD. Apoptosis in lung pathophysiology. Am J Physiol Lung Cell Mol Physiol. 2000 Sep; 279(3):L423-7.
    View in: PubMed
  39. Gochuico BR, Zhang J, Ma BY, Marshak-Rothstein A, Fine A. TRAIL expression in vascular smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2000 May; 278(5):L1045-50.
    View in: PubMed
  40. Matsui K, Xiao S, Fine A, Ju ST. Role of activator protein-1 in TCR-mediated regulation of the murine fasl promoter. J Immunol. 2000 Mar 15; 164(6):3002-8.
    View in: PubMed
  41. Zhang J, Miranda K, Ma BY, Fine A. Molecular characterization of the mouse Fas ligand promoter in airway epithelial cells. Biochim Biophys Acta. 2000 Feb 29; 1490(3):291-301.
    View in: PubMed
  42. Xiao S, Matsui K, Fine A, Zhu B, Marshak-Rothstein A, Widom RL, Ju ST. FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3. Eur J Immunol. 1999 Nov; 29(11):3456-65.
    View in: PubMed
  43. Lee FE, Caracta CF, Fine A, Berk JL. Fevers, weight loss, and bilateral peripheral infiltrates in a young man. Chest. 1999 Apr; 115(4):1181-3.
    View in: PubMed
  44. Matsui K, Fine A, Zhu B, Marshak-Rothstein A, Ju ST. Identification of two NF-kappa B sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma. J Immunol. 1998 Oct 1; 161(7):3469-73.
    View in: PubMed
  45. Pang H, Miranda K, Fine A. Sp3 regulates fas expression in lung epithelial cells. Biochem J. 1998 Jul 1; 333 ( Pt 1):209-13.
    View in: PubMed
  46. Gochuico BR, Miranda KM, Hessel EM, De Bie JJ, Van Oosterhout AJ, Cruikshank WW, Fine A. Airway epithelial Fas ligand expression: potential role in modulating bronchial inflammation. Am J Physiol. 1998 Mar; 274(3 Pt 1):L444-9.
    View in: PubMed
  47. Fine A, Miranda K, Farmer SR, Anderson NL. Effect of insoluble extracellular matrix molecules on Fas expression in epithelial cells. J Cell Physiol. 1998 Mar; 174(3):285-92.
    View in: PubMed
  48. Fine A, Anderson NL, Rothstein TL, Williams MC, Gochuico BR. Fas expression in pulmonary alveolar type II cells. Am J Physiol. 1997 Jul; 273(1 Pt 1):L64-71.
    View in: PubMed
  49. Gochuico BR, Williams MC, Fine A. Simultaneous in situ hybridization and TUNEL to identify cells undergoing apoptosis. Histochem J. 1997 May; 29(5):413-8.
    View in: PubMed
  50. Bloom BB, Humphries DE, Kuang PP, Fine A, Goldstein RH. Structure and expression of the promoter for the R4/ALK5 human type I transforming growth factor-beta receptor: regulation by TGF-beta. Biochim Biophys Acta. 1996 Jul 24; 1312(3):243-8.
    View in: PubMed
  51. Krupsky M, Fine A, Kuang PP, Berk JL, Goldstein RH. Regulation of type I collagen production by insulin and transforming growth factor-beta in human lung fibroblasts. Connect Tissue Res. 1996; 34(1):53-62.
    View in: PubMed
  52. Goldstein RH, Fine A. Potential therapeutic initiatives for fibrogenic lung diseases. Chest. 1995 Sep; 108(3):848-55.
    View in: PubMed
  53. Fine A, Panchenko MP, Smith BD, Yu Q, Goldstein RH. Discordant regulation of transforming growth factor-beta receptors by prostaglandin E2. Biochim Biophys Acta. 1995 Mar 14; 1261(1):19-24.
    View in: PubMed
  54. Krupsky M, Fine A, Berk JL, Goldstein RH. Retinoic acid-induced inhibition of type I collagen gene expression by human lung fibroblasts. Biochim Biophys Acta. 1994 Oct 18; 1219(2):335-41.
    View in: PubMed
  55. Humphries DE, Bloom BB, Fine A, Goldstein RH. Structure and expression of the promoter for the human type II transforming growth factor-beta receptor. Biochem Biophys Res Commun. 1994 Sep 15; 203(2):1020-7.
    View in: PubMed
  56. Matsui R, Goldstein RH, Mihal K, Brody JS, Steele MP, Fine A. Type I collagen formation in rat type II alveolar cells immortalised by viral gene products. Thorax. 1994 Mar; 49(3):201-6.
    View in: PubMed
  57. Krupsky M, Fine A, Berk JL, Goldstein RH. The effect of retinoic acid on amino acid uptake and protein synthesis by lung fibroblasts. J Biol Chem. 1993 Nov 5; 268(31):23283-8.
    View in: PubMed
  58. Ritzenthaler JD, Goldstein RH, Fine A, Smith BD. Regulation of the alpha 1(I) collagen promoter via a transforming growth factor-beta activation element. J Biol Chem. 1993 Jun 25; 268(18):13625-31.
    View in: PubMed
  59. Fine A, Goldstein RH. Regulation of type I collagen mRNA translation by TGF-beta. Reg Immunol. 1993 May-Aug; 5(3-4):218-24.
    View in: PubMed
  60. Fine A, Matsui R, Zhan X, Poliks CF, Smith BD, Goldstein RH. Discordant regulation of human type I collagen genes by prostaglandin E2. Biochim Biophys Acta. 1992 Apr 30; 1135(1):67-72.
    View in: PubMed
  61. Ritzenthaler JD, Goldstein RH, Fine A, Lichtler A, Rowe DW, Smith BD. Transforming-growth-factor-beta activation elements in the distal promoter regions of the rat alpha 1 type I collagen gene. Biochem J. 1991 Nov 15; 280 ( Pt 1):157-62.
    View in: PubMed
  62. Fine A, Goldstein RH. Mechanisms of transforming growth factor-beta-induced collagen formation by human lung fibroblasts. Chest. 1991 Mar; 99(3 Suppl):84S.
    View in: PubMed
  63. Goldstein RH, Fine A, Farnsworth LJ, Poliks C, Polgar P. Phorbol ester-induced inhibition of collagen accumulation by human lung fibroblasts. J Biol Chem. 1990 Aug 15; 265(23):13623-8.
    View in: PubMed
  64. Fine A, Poliks CF, Smith BD, Goldstein RH. The accumulation of type I collagen mRNAs in human embryonic lung fibroblasts stimulated by transforming growth factor-beta. Connect Tissue Res. 1990; 24(3-4):237-47.
    View in: PubMed
  65. Fine A, Poliks CF, Donahue LP, Smith BD, Goldstein RH. The differential effect of prostaglandin E2 on transforming growth factor-beta and insulin-induced collagen formation in lung fibroblasts. J Biol Chem. 1989 Oct 15; 264(29):16988-91.
    View in: PubMed
  66. Goldstein RH, Poliks CF, Pilch PF, Smith BD, Fine A. Stimulation of collagen formation by insulin and insulin-like growth factor I in cultures of human lung fibroblasts. Endocrinology. 1989 Feb; 124(2):964-70.
    View in: PubMed
  67. Fine A, Goldstein RH. The effect of PGE2 on the activation of quiescent lung fibroblasts. Prostaglandins. 1987 Jun; 33(6):903-13.
    View in: PubMed
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