Keywords
Last Name

Jesus Paez-Cortez, MD, PhD

TitlePostdoctoral Fellow
InstitutionBoston University School of Medicine
DepartmentPulmonary
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-4860
 Awards and Honors

Start-EndDescription
2006-2009American Diabetes Association : Mentor-Based Minority Postdoctoral Fellowship
2011Assembly on Pulmonary Circulation. ATS International Conference in Denver, Colorado. : Distinguished Work
 Research Expertise & Professional Interests
I am focused in evaluating the developmental role and signaling properties of Notch3 receptor in the mouse pulmonary artery. Notch3 is essential in maintaining morphological characteristics and smooth muscle gene expression profile of the pulmonary artery after birth. Notch signaling involve a two cell system composed of a signal receiving cell that expresses a Notch receptor on its surface and a neighboring signal-sending cell that provides membrane-bound activating ligand, however our current data suggest that pulmonary artery vascular smooth muscle cells (VSMCs) challenge this paradigm. Notch3 activation in lung VSMCs is cell autonomous.

We are interested in the fields of lung developmental biology, lung smooth muscle maturation, pulmonary hypertension and asthma.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H, Cardoso WV. Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. Development. 2015 Jan 15; 142(2):258-67. PMID: 25564622.
    View in: PubMed
  2. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81. PMID: 24313705.
    View in: PubMed
  3. Aven L, Paez-Cortez J, Achey R, Krishnan R, Ram-Mohan S, Cruikshank WW, Fine A, Ai X. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb; 28(2):897-907. PMID: 24221086.
    View in: PubMed
  4. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469. PMID: 24040256.
    View in: PubMed
  5. Ghatnekar A, Chrobak I, Reese C, Stawski L, Seta F, Wirrig E, Paez-Cortez J, Markiewicz M, Asano Y, Harley R, Silver R, Feghali-Bostwick C, Trojanowska M. Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension. Am J Pathol. 2013 Jun; 182(6):2391-406. PMID: 23583651.
    View in: PubMed
  6. Radzikinas K, Aven L, Jiang Z, Tran T, Paez-Cortez J, Boppidi K, Lu J, Fine A, Ai X. A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle. J Neurosci. 2011 Oct 26; 31(43):15407-15. PMID: 22031887.
    View in: PubMed
  7. Ghosh S, Paez-Cortez JR, Boppidi K, Vasconcelos M, Roy M, Cardoso W, Ai X, Fine A. Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery. J Biol Chem. 2011 Jun 24; 286(25):22678-87. PMID: 21536678.
    View in: PubMed
  8. Wittig O, Paez-Cortez J, Cardier JE. Liver sinusoidal endothelial cells promote B lymphopoiesis from primitive hematopoietic cells. Stem Cells Dev. 2010 Mar; 19(3):341-50. PMID: 19788396.
    View in: PubMed
  9. Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10734-9. PMID: 19528638.
    View in: PubMed
  10. Ueno T, Tanaka K, Jurewicz M, Murayama T, Guleria I, Fiorina P, Paez JC, Augello A, Vergani A, Wong M, Smith RN, Abdi R. Divergent role of donor dendritic cells in rejection versus tolerance of allografts. J Am Soc Nephrol. 2009 Mar; 20(3):535-44. PMID: 19129312.
    View in: PubMed
  11. Yuan X, Paez-Cortez J, Schmitt-Knosalla I, D'Addio F, Mfarrej B, Donnarumma M, Habicht A, Clarkson MR, Iacomini J, Glimcher LH, Sayegh MH, Ansari MJ. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med. 2008 Dec 22; 205(13):3133-44. PMID: 19047438.
    View in: PubMed
  12. Paez-Cortez J, Montano R, Iacomini J, Cardier J. Liver sinusoidal endothelial cells as possible vehicles for gene therapy: a comparison between plasmid-based and lentiviral gene transfer techniques. Endothelium. 2008 Jul-Aug; 15(4):165-73. PMID: 18663620.
    View in: PubMed
  13. Fiorina P, Jurewicz M, Vergani A, Augello A, Paez J, Ricchiuti V, Tchipachvili V, Sayegh MH, Abdi R. Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantation. Transplantation. 2008 Apr 15; 85(7):1030-8. PMID: 18408585.
    View in: PubMed
  14. Bagley J, Paez-Cortez J, Tian C, Iacomini J. Gene therapy in type 1 diabetes. Crit Rev Immunol. 2008; 28(4):301-24. PMID: 19166382.
    View in: PubMed
  15. Tian C, Ansari MJ, Paez-Cortez J, Bagley J, Godwin J, Donnarumma M, Sayegh MH, Iacomini J. Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy. J Immunol. 2007 Nov 15; 179(10):6762-9. PMID: 17982066.
    View in: PubMed
  16. Paez J, MontaƱo R, Benatuil L, Iacomini J, Cardier JE. High efficiency and long-term foreign gene expression in cultured liver sinusoidal endothelial cells by retroviral transduction. Endothelium. 2006 Jul-Aug; 13(4):279-85. PMID: 16990184.
    View in: PubMed
  17. Forman D, Kang ES, Tian C, Paez-Cortez J, Iacomini J. Induction of alloreactive CD4 T cell tolerance in molecular chimeras: a possible role for regulatory T cells. J Immunol. 2006 Mar 15; 176(6):3410-6. PMID: 16517709.
    View in: PubMed
  18. Luna G, Paez J, Cardier JE. Expression of the hematopoietic stem cell antigen Sca-1 (LY-6A/E) in liver sinusoidal endothelial cells: possible function of Sca-1 in endothelial cells. Stem Cells Dev. 2004 Oct; 13(5):528-35. PMID: 15588510.
    View in: PubMed
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