Jesus Paez-Cortez, MD, PhD
Molecular & Cell Biology Research Fellow
Vertex Pharmaceuticals
Research

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I am focused in evaluating the developmental role and signaling properties of Notch3 receptor in the mouse pulmonary artery. Notch3 is essential in maintaining morphological characteristics and smooth muscle gene expression profile of the pulmonary artery after birth. Notch signaling involve a two cell system composed of a signal receiving cell that expresses a Notch receptor on its surface and a neighboring signal-sending cell that provides membrane-bound activating ligand, however our current data suggest that pulmonary artery vascular smooth muscle cells (VSMCs) challenge this paradigm. Notch3 activation in lung VSMCs is cell autonomous.

We are interested in the fields of lung developmental biology, lung smooth muscle maturation, pulmonary hypertension and asthma.

Postdoctoral Fellow (previously held)
Boston University Chobanian & Avedisian School of Medicine
Pulmonary


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Jin L, Macoritto M, Wang J, Bi Y, Wang F, Suarez-Fueyo A, Paez-Cortez J, Hu C, Knight H, Mascanfroni I, Staron MM, Schwartz Sterman A, Houghton JM, Westmoreland S, Tian Y. Multi-Omics Characterization of Colon Mucosa and Submucosa/Wall from Crohn's Disease Patients. Int J Mol Sci. 2024 May 08; 25(10). PMID: 38791146; PMCID: PMC11121447; DOI: 10.3390/ijms25105108;
     
  2. Zhu Q, Korenfeld D, Suarez-Fueyo A, Graham S, Jin L, Punit S, Duffy R, Puri M, Caruso A, Hu C, Tian Y, McRae BL, Kamath R, Phillips L, Schwartz-Sterman AJ, Westmoreland S, Cao X, Levesque MC, Bi Y, Paez-Cortez J, Goenka R. Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease. Mucosal Immunol. 2022 Jun; 15(6):1338-1349. PMID: 36372810
     
  3. Edwards SC, Sutton CE, Ladell K, Grant EJ, McLaren JE, Roche F, Dash P, Apiwattanakul N, Awad W, Miners KL, Lalor SJ, Ribot JC, Baik S, Moran B, McGinley A, Pivorunas V, Dowding L, Macoritto M, Paez-Cortez J, Slavin A, Anderson G, Silva-Santos B, Hokamp K, Price DA, Thomas PG, McLoughlin RM, Mills KHG. A population of proinflammatory T cells coexpresses aß and ?d T cell receptors in mice and humans. J Exp Med. 2020 05 04; 217(5). PMID: 32106283; PMCID: PMC7201916; DOI: 10.1084/jem.20190834;
     
  4. Jin L, Li L, Hu C, Paez-Cortez J, Bi Y, Macoritto M, Cao S, Tian Y. Integrative Analysis of Transcriptomic and Proteomic Profiling in Inflammatory Bowel Disease Colon Biopsies. Inflamm Bowel Dis. 2019 11 14; 25(12):1906-1918. PMID: 31173627
     
  5. Paustian AMS, Paez-Cortez J, Bryant S, Westmoreland S, Waegell W, Kingsbury G. Continuous IL-23 stimulation drives ILC3 depletion in the upper GI tract and, in combination with TNFa, induces robust activation and a phenotypic switch of ILC3. PLoS One. 2017; 12(8):e0182841. PMID: 28792532; PMCID: PMC5549730; DOI: 10.1371/journal.pone.0182841;
     
  6. Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H, Cardoso WV. Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. Development. 2015 Jan 15; 142(2):258-67.View Related Profiles. PMID: 25564622; PMCID: PMC4302835; DOI: 10.1242/dev.116855;
     
  7. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81.View Related Profiles. PMID: 24313705; PMCID: PMC4068941; DOI: 10.1165/rcmb.2013-0166MA;
     
  8. Aven L, Paez-Cortez J, Achey R, Krishnan R, Ram-Mohan S, Cruikshank WW, Fine A, Ai X. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb; 28(2):897-907.View Related Profiles. PMID: 24221086; PMCID: PMC3898648; DOI: 10.1096/fj.13-238212;
     
  9. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469.View Related Profiles. PMID: 24040256; PMCID: PMC3767675; DOI: 10.1371/journal.pone.0074469;
     
  10. Ghatnekar A, Chrobak I, Reese C, Stawski L, Seta F, Wirrig E, Paez-Cortez J, Markiewicz M, Asano Y, Harley R, Silver R, Feghali-Bostwick C, Trojanowska M. Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension. Am J Pathol. 2013 Jun; 182(6):2391-406.View Related Profiles. PMID: 23583651; PMCID: PMC3668018; DOI: 10.1016/j.ajpath.2013.02.039;
     
Showing 10 of 23 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 23 publications over 15 distinct years, with a maximum of 4 publications in 2008

YearPublications
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20062
20071
20084
20092
20101
20112
20133
20141
20151
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2011 Assembly on Pulmonary Circulation. ATS International Conference in Denver, Colorado. : Distinguished Work
2006-2009 American Diabetes Association : Mentor-Based Minority Postdoctoral Fellowship
Contact for Mentoring:

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