Jesus Paez-Cortez, MD, PhD
|Institution||Boston University School of Medicine|
|Address||72 E. Concord St Housman (R)|
Boston MA 02118
|2006||-||2009||American Diabetes Association :
Mentor-Based Minority Postdoctoral Fellowship|
|2011||Assembly on Pulmonary Circulation. ATS International Conference in Denver, Colorado. :
I am focused in evaluating the developmental role and signaling properties of Notch3 receptor in the mouse pulmonary artery. Notch3 is essential in maintaining morphological characteristics and smooth muscle gene expression profile of the pulmonary artery after birth. Notch signaling involve a two cell system composed of a signal receiving cell that expresses a Notch receptor on its surface and a neighboring signal-sending cell that provides membrane-bound activating ligand, however our current data suggest that pulmonary artery vascular smooth muscle cells (VSMCs) challenge this paradigm. Notch3 activation in lung VSMCs is cell autonomous.
We are interested in the fields of lung developmental biology, lung smooth muscle maturation, pulmonary hypertension and asthma.