Jesus Paez-Cortez, MD, PhD
Postdoctoral Fellow
Boston University School of Medicine
Dept of Pulmonary




I am focused in evaluating the developmental role and signaling properties of Notch3 receptor in the mouse pulmonary artery. Notch3 is essential in maintaining morphological characteristics and smooth muscle gene expression profile of the pulmonary artery after birth. Notch signaling involve a two cell system composed of a signal receiving cell that expresses a Notch receptor on its surface and a neighboring signal-sending cell that provides membrane-bound activating ligand, however our current data suggest that pulmonary artery vascular smooth muscle cells (VSMCs) challenge this paradigm. Notch3 activation in lung VSMCs is cell autonomous.

We are interested in the fields of lung developmental biology, lung smooth muscle maturation, pulmonary hypertension and asthma.

2011 Assembly on Pulmonary Circulation. ATS International Conference in Denver, Colorado. : Distinguished Work
2006-2009 American Diabetes Association : Mentor-Based Minority Postdoctoral Fellowship
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H, Cardoso WV. Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. Development. 2015 Jan 15; 142(2):258-67.View Related Profiles. PMID: 25564622; PMCID: PMC4302835; DOI: 10.1242/dev.116855;.
  2. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81.View Related Profiles. PMID: 24313705; PMCID: PMC4068941; DOI: 10.1165/rcmb.2013-0166MA;.
  3. Aven L, Paez-Cortez J, Achey R, Krishnan R, Ram-Mohan S, Cruikshank WW, Fine A, Ai X. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb; 28(2):897-907.View Related Profiles. PMID: 24221086; PMCID: PMC3898648; DOI: 10.1096/fj.13-238212;.
  4. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469.View Related Profiles. PMID: 24040256; PMCID: PMC3767675; DOI: 10.1371/journal.pone.0074469;.
  5. Ghatnekar A, Chrobak I, Reese C, Stawski L, Seta F, Wirrig E, Paez-Cortez J, Markiewicz M, Asano Y, Harley R, Silver R, Feghali-Bostwick C, Trojanowska M. Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension. Am J Pathol. 2013 Jun; 182(6):2391-406.View Related Profiles. PMID: 23583651; PMCID: PMC3668018; DOI: 10.1016/j.ajpath.2013.02.039;.
  6. Radzikinas K, Aven L, Jiang Z, Tran T, Paez-Cortez J, Boppidi K, Lu J, Fine A, Ai X. A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle. J Neurosci. 2011 Oct 26; 31(43):15407-15.View Related Profiles. PMID: 22031887; PMCID: PMC3222097; DOI: 10.1523/JNEUROSCI.2745-11.2011;.
  7. Ghosh S, Paez-Cortez JR, Boppidi K, Vasconcelos M, Roy M, Cardoso W, Ai X, Fine A. Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery. J Biol Chem. 2011 Jun 24; 286(25):22678-87.View Related Profiles. PMID: 21536678; PMCID: PMC3121411; DOI: 10.1074/jbc.M111.241224;.
  8. Wittig O, Paez-Cortez J, Cardier JE. Liver sinusoidal endothelial cells promote B lymphopoiesis from primitive hematopoietic cells. Stem Cells Dev. 2010 Mar; 19(3):341-50. PMID: 19788396; DOI: 10.1089/scd.2009.0300;.
  9. Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10734-9. PMID: 19528638; PMCID: PMC2705547; DOI: 10.1073/pnas.0812538106;.
  10. Ueno T, Tanaka K, Jurewicz M, Murayama T, Guleria I, Fiorina P, Paez JC, Augello A, Vergani A, Wong M, Smith RN, Abdi R. Divergent role of donor dendritic cells in rejection versus tolerance of allografts. J Am Soc Nephrol. 2009 Mar; 20(3):535-44. PMID: 19129312; PMCID: PMC2653678; DOI: 10.1681/ASN.2008040377;.
Showing 10 of 18 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 18 publications over 10 distinct years, with a maximum of 4 publications in 2008

YearPublications
20041
20062
20071
20084
20092
20101
20112
20133
20141
20151
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72 E. Concord St Housman (R)
Boston MA 02118
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