Xaralabos Varelas, PhD
|Institution||Boston University School of Medicine|
|Address||72 E. Concord St Silvio Conte (K)|
Boston MA 02118
Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles and regulation of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway.
YAP/TAZ integrate cell polarity and mechanical cues with information relayed by growth factors and chemicals to direct essential processes and maintain organ homeostasis. The lab is incorporating genetic and biochemical approaches to define how YAP/TAZ control developmental events, and how dysregulation of YAP/TAZ activity contributes the etiology of various diseases, such as cancer.
- Cell Polarity
- Hippo pathway signaling
- TGF-beta pathway signaling
- Wnt signaling
- Lung development and disease
- Epithelial biology
- Cancer biology
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