Keywords
Last Name

Xaralabos Varelas, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry
Address72 E. Concord St Silvio Conte (K)
Boston MA 02118
Phone(617) 638-4182
ORCID ORCID Icon0000-0002-2882-4541
 Research Expertise & Professional Interests
Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles and regulation of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway.

YAP/TAZ integrate cell polarity and mechanical cues with information relayed by growth factors and chemicals to direct essential processes and maintain organ homeostasis. The lab is incorporating genetic and biochemical approaches to define how YAP/TAZ control developmental events, and how dysregulation of YAP/TAZ activity contributes the etiology of various diseases, such as cancer.

 Self-Described Keywords
  • Cell Polarity
  • YAP/TAZ
  • Hippo pathway signaling
  • TGF-beta pathway signaling
  • Wnt signaling
  • Lung development and disease
  • Epithelial biology
  • Cancer biology
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Zhang L, Yang CS, Varelas X, Monti S. Altered RNA editing in 3' UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors. Sci Rep. 2016 Mar 16; 6:23226. PMID: 26980570.
    View in: PubMed
  2. Szymaniak AD, Mahoney JE, Cardoso WV, Varelas X. Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell. 2015 Aug 10; 34(3):283-96. PMID: 26235047.
    View in: PubMed
  3. Hiemer SE, Zhang L, Kartha VK, Packer TS, Almershed M, Noonan V, Kukuruzinska M, Bais MV, Monti S, Varelas X. A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma. Mol Cancer Res. 2015 Jun; 13(6):957-68. PMID: 25794680.
    View in: PubMed
  4. Narimatsu M, Samavarchi-Tehrani P, Varelas X, Wrana JL. Distinct polarity cues direct Taz/Yap and TGFß receptor localization to differentially control TGFß-induced Smad signaling. Dev Cell. 2015 Mar 9; 32(5):652-6. PMID: 25758863.
    View in: PubMed
  5. Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H, Cardoso WV. Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors. Development. 2015 Jan 15; 142(2):258-67. PMID: 25564622.
    View in: PubMed
  6. Liu F, Lagares D, Choi KM, Stopfer L, Marinkovic A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15; 308(4):L344-57. PMID: 25502501.
    View in: PubMed
  7. Varelas X, Kukuruzinska MA. Head and neck cancer: from research to therapy and cure. Ann N Y Acad Sci. 2014 Dec; 1333:1-32. PMID: 25532687.
    View in: PubMed
  8. Mahoney JE, Mori M, Szymaniak AD, Varelas X, Cardoso WV. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell. 2014 Jul 28; 30(2):137-50. PMID: 25043473.
    View in: PubMed
  9. Varelas X, Bouchie MP, Kukuruzinska MA. Protein N-glycosylation in oral cancer: dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling. Glycobiology. 2014 Jul; 24(7):579-91. PMID: 24742667.
    View in: PubMed
  10. Varelas X. The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development. 2014 Apr; 141(8):1614-26. PMID: 24715453.
    View in: PubMed
  11. Hiemer SE, Szymaniak AD, Varelas X. The transcriptional regulators TAZ and YAP direct transforming growth factor ß-induced tumorigenic phenotypes in breast cancer cells. J Biol Chem. 2014 May 9; 289(19):13461-74. PMID: 24648515.
    View in: PubMed
  12. Beyer TA, Weiss A, Khomchuk Y, Huang K, Ogunjimi AA, Varelas X, Wrana JL. Switch enhancers interpret TGF-ß and Hippo signaling to control cell fate in human embryonic stem cells. Cell Rep. 2013 Dec 26; 5(6):1611-24. PMID: 24332857.
    View in: PubMed
  13. Chaulk SG, Lattanzi VJ, Hiemer SE, Fahlman RP, Varelas X. The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7. J Biol Chem. 2014 Jan 24; 289(4):1886-91. PMID: 24324261.
    View in: PubMed
  14. Enger TB, Samad-Zadeh A, Bouchie MP, Skarstein K, Galtung HK, Mera T, Walker J, Menko AS, Varelas X, Faustman DL, Jensen JL, Kukuruzinska MA. The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome. Lab Invest. 2013 Nov; 93(11):1203-18. PMID: 24080911.
    View in: PubMed
  15. Liu G, Sengupta PK, Jamal B, Yang HY, Bouchie MP, Lindner V, Varelas X, Kukuruzinska MA. N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration. J Biol Chem. 2013 Jul 12; 288(28):20217-27. PMID: 23703614.
    View in: PubMed
  16. Hiemer SE, Varelas X. Stem cell regulation by the Hippo pathway. Biochim Biophys Acta. 2013 Feb; 1830(2):2323-34. PMID: 22824335.
    View in: PubMed
  17. Varelas X, Wrana JL. Coordinating developmental signaling: novel roles for the Hippo pathway. Trends Cell Biol. 2012 Feb; 22(2):88-96. PMID: 22153608.
    View in: PubMed
  18. Mauviel A, Nallet-Staub F, Varelas X. Integrating developmental signals: a Hippo in the (path)way. Oncogene. 2012 Apr 5; 31(14):1743-56. PMID: 21874053.
    View in: PubMed
  19. Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F. An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell. 2011 Jun 24; 145(7):1075-87. PMID: 21683433.
    View in: PubMed
  20. Varelas X, Samavarchi-Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen BG, Rossant J, Wrana JL. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-ß-SMAD pathway. Dev Cell. 2010 Dec 14; 19(6):831-44. PMID: 21145499.
    View in: PubMed
  21. Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010 Apr 20; 18(4):579-91. PMID: 20412773.
    View in: PubMed
  22. Ogunjimi AA, Wiesner S, Briant DJ, Varelas X, Sicheri F, Forman-Kay J, Wrana JL. The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. J Biol Chem. 2010 Feb 26; 285(9):6308-15. PMID: 20026602.
    View in: PubMed
  23. Sopko R, Silva E, Clayton L, Gardano L, Barrios-Rodiles M, Wrana J, Varelas X, Arbouzova NI, Shaw S, Saburi S, Matakatsu H, Blair S, McNeill H. Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown. Curr Biol. 2009 Jul 14; 19(13):1112-7. PMID: 19540118.
    View in: PubMed
  24. Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol. 2008 Jul; 10(7):837-48. PMID: 18568018.
    View in: PubMed
  25. Varelas X, Stuart D, Ellison MJ, Ptak C. The Cdc34/SCF ubiquitination complex mediates Saccharomyces cerevisiae cell wall integrity. Genetics. 2006 Dec; 174(4):1825-39. PMID: 17028344.
    View in: PubMed
  26. Ptak C, Varelas X, Moraes T, McKenna S, Ellison MJ. Purification and properties of the ubiquitin-conjugating enzymes Cdc34 and Ubc13.Mms2. Methods Enzymol. 2005; 398:43-54. PMID: 16275318.
    View in: PubMed
  27. Varelas X, Ptak C, Ellison MJ. Cdc34 self-association is facilitated by ubiquitin thiolester formation and is required for its catalytic activity. Mol Cell Biol. 2003 Aug; 23(15):5388-400. PMID: 12861024.
    View in: PubMed
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