Xaralabos Varelas, PhD
Associate Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Alberta



Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles and regulation of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway.

YAP/TAZ integrate cell polarity and mechanical cues with information relayed by growth factors and chemicals to direct essential processes and maintain organ homeostasis. The lab is incorporating genetic and biochemical approaches to define how YAP/TAZ control developmental events, and how dysregulation of YAP/TAZ activity contributes the etiology of various diseases, such as cancer.


Understanding aberrant YAP signaling in squamous cell lung cancer
07/01/2017 - 06/30/2021 (PI)
American Cancer Society, Inc.

Understanding the Molecular Mechanisms Controlling Multi-cilia Development
06/01/2017 - 05/31/2020 (PI)
March of Dimes Foundation

Defining Epithelial Cues Contributing to Sjogren's Syndrome
07/01/2016 - 06/30/2018 (PI)
Sjogren's Syndrome Foundation

Defining Epithelial Cell Polarity Cues That Direct Cell Fate
08/15/2014 - 04/30/2018 (PI)
NIH/National Heart, Lung, and Blood Inst
5R01HL124392-03

Mechanobiology of Lung Fibrosis
12/01/2014 - 11/30/2017 (PI)
Mayo Clinic NIH NHLBI
5R01HL092961-07

Defining aberrant epithelial cell polarity-regulated cues in breast cancer
09/01/2014 - 08/31/2017 (PI)
Department of Defense/Army Medical Resea

Regulation of the Ciliated Cell Program in Airway Progenitors
06/01/2016 - 05/31/2017 (PI)
Trustees Of Columbia University In The C NIH NHLBI
5R01HL119836-03

Specification and patterning of the developing airway by cell polarity regulated cues
06/01/2014 - 05/31/2017 (PI)
March of Dimes Foundation

Defective Cell Polarity and Hippo Signalling in the Etiology of Sjogren's Syndrome
04/01/2014 - 03/31/2016 (Co-PI)
PI: Maria A. Kukuruzinska, PhD
Biogen Idec

Institutional Research Grant
01/01/2012 - 12/31/2015 (PI of Sub-Project / SP)
PI: Avrum Spira, MD
American Cancer Society - MA Division

Showing 10 of 14 results. Show All Results


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O''Carroll D, Jones MR. Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02; 127(10):3866-3876.View Related Profiles. PMID: 28920925.
  2. Hicks-Berthet J, Varelas X. Integrin-FAK-CDC42-PP1A signaling gnaws at YAP/TAZ activity to control incisor stem cells. Bioessays. 2017 Oct; 39(10). PMID: 28891248.
  3. Toyama T, Looney AP, Baker BM, Stawski L, Haines P, Simms R, Szymaniak AD, Varelas X, Trojanowska M. Therapeutic targeting of TAZ and YAP by dimethyl fumarate in systemic sclerosis fibrosis. J Invest Dermatol. 2017 Sep 01.View Related Profiles. PMID: 28870693.
  4. Dieffenbach PB, Haeger CM, Coronata AMF, Choi KM, Varelas X, Tschumperlin DJ, Fredenburgh LE. Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 01; 313(3):L628-L647. PMID: 28642262.
  5. Szymaniak AD, Mi R, McCarthy SE, Gower AC, Reynolds TL, Mingueneau M, Kukuruzinska M, Varelas X. The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland. Elife. 2017 May 11; 6.View Related Profiles. PMID: 28492365.
  6. Rohban MH, Singh S, Wu X, Berthet JB, Bray MA, Shrestha Y, Varelas X, Boehm JS, Carpenter AE. Systematic morphological profiling of human gene and allele function via Cell Painting. Elife. 2017 Mar 18; 6.View Related Profiles. PMID: 28315521; DOI: 10.7554/eLife.24060;.
  7. Jorgenson AJ, Choi KM, Sicard D, Smith KM, Hiemer SE, Varelas X, Tschumperlin DJ. TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression. Am J Physiol Cell Physiol. 2017 Mar 01; 312(3):C277-C285.View Related Profiles. PMID: 27881410; DOI: 10.1152/ajpcell.00205.2016;.
  8. Zhang L, Yang CS, Varelas X, Monti S. Altered RNA editing in 3'' UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors. Sci Rep. 2016 Mar 16; 6:23226.View Related Profiles. PMID: 26980570; PMCID: PMC4793219; DOI: 10.1038/srep23226;.
  9. Szymaniak AD, Mahoney JE, Cardoso WV, Varelas X. Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell. 2015 Aug 10; 34(3):283-96.View Related Profiles. PMID: 26235047; PMCID: PMC4536126; DOI: 10.1016/j.devcel.2015.06.020;.
  10. Hiemer SE, Zhang L, Kartha VK, Packer TS, Almershed M, Noonan V, Kukuruzinska M, Bais MV, Monti S, Varelas X. A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma. Mol Cancer Res. 2015 Jun; 13(6):957-68.View Related Profiles. PMID: 25794680; PMCID: PMC4470857; DOI: 10.1158/1541-7786.MCR-14-0580;.
Showing 10 of 34 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 34 publications over 13 distinct years, with a maximum of 6 publications in 2014 and 2017

YearPublications
20031
20051
20061
20081
20092
20102
20113
20121
20134
20146
20154
20162
20176
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Cancer biology
Cell Polarity
Epithelial biology
Hippo pathway signaling
Lung development and disease
TGF-beta pathway signaling
Wnt signaling
YAP/TAZ
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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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