Xaralabos Varelas, PhD
|Institution||Boston University School of Medicine|
|Address||72 E. Concord St Silvio Conte (K)|
Boston MA 02118
The research objective of our lab is to understand the molecular mechanisms by which cells coordinate growth with cell fate during animal development and the onset of disease. We are particularly interested in the role of the Hippo tumor suppressor pathway in controlling these processes. The Hippo pathway has emerged as a major regulator of tissue growth and organ size, and has a crucial role in directing signals that are transmitted by secreted growth factors, such those initiated by TGFß and Wnt. Deregulation of the Hippo pathway is linked to many diseases, including several forms of cancer. We are incorporating both directed and systems-based approaches to understand the roles and regulation of the Hippo pathway, with an emphasis on defining deregulated events that impact on tumor initiation and progression.
- Cell Polarity
- Hippo pathway
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