Keywords
Last Name

Paola Sebastiani, PhD

TitleProfessor
InstitutionBoston University School of Public Health
DepartmentBiostatistics
Address801 Massachusetts Ave Crosstown Center
Boston MA 02118
Phone(617) 638-5877
ORCID ORCID Icon0000-0001-6419-1545
Other Positions
InstitutionBoston Medical Center

TitleMember
InstitutionBoston University
DepartmentBioinformatics Graduate Program

 Research Expertise & Professional Interests
Paola Sebastiani, Ph.D. joined the Department of Biostatistics in 2003 as an Associate Professor, after holding faculty positions in Italy, England and United States. She is author of more than 200 peer-reviewed publications in theoretical and methodological statistics, artificial intelligence, computational biology and genetics. She is statistical consultant for Circulation and also a regular reviewer for major journals in statistics and computer science, and serves on the program committee of several international conferences at the interface between statistics and artificial intelligence. When she joined the Department of Biostatistics at Boston University in 2003, Dr. Sebastiani had experience in interdisciplinary collaborations and a track record of developing novel methodologies in Bayesian statistics, machine learning, decision theory, graphical modeling and statistical experimental design. She leveraged this experience to develop a wide network of collaborations with investigators from the Bioinformatics program, the Genetics and Genomics program, and the Molecular and Translational Medicine Program. The main feature of these collaborations is that in addition to using existing statistical methods, Dr. Sebastiani often introduced original solutions by developing innovative Bayesian techniques for the analysis of genomic and genetic data and for the joint modeling of the genetic, genomic and phenotypic basis of complex traits. This work has been supported by the National Science Foundation and the National Institutes for Health and is currently funded by grants of which Dr. Sebastiani is Principal Investigator. Her contributions include, among others, a Bayesian model-based clustering procedure of temporal expression profiles (CAGED), a robust Bayesian approach to analyze differential gene expression using model averaging (BADGE), and novel methods for analysis of genetic data. Dr. Sebastiani was a pioneer in using a Bayesian network approach to model the genetic and phenotypic basis of complications of sickle cell anemia. She developed the first network model for predicting stroke in patients with sickle cell anemia and a network-based prognostic model that integrates sub-phenotypes of sickle cell anemia patients into a score of the overall severity of disease. This model was successfully evaluated by independent investigators and has opened several new research areas in sickle cell disease. These results were the fruit of a long and productive collaboration with Dr. Steinberg to study the genetic basis of different clinical presentations of sickle cell disease.

Dr. Sebastiani has also cultivated a strong and growing reputation as a biostatistician in the fields of gerontology, biology and epidemiology of human aging and longevity. She is the primary statistician of the BU site of the Long Life Family Study, and of the New England Centenarian Study directed by Dr. Thomas Perls. Dr. Sebastiani used an original Bayesian approach to verify the “compression of morbidity hypothesis” that had long been debated in the field of gerontology, developed a method for scoring sibships for familial longevity that can be used to enroll the most informative families in observational studies of human longevity, and introduced a novel Bayesian approach to model the genetic and phenotypic basis of exceptional human longevity. The analysis provides evidence that extreme human longevity is not due to absence of disease variants but to rare combinations of large numbers of common protective variants. Her current work focuses on the discovery of genetic modifiers of sickle cell anemia phenotypes using genetic data and IPS cell based models, and the biology of aging using a system-based approach.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Brogly SB, Saia KA, Walley AY, Du HM, Sebastiani P. Prenatal buprenorphine versus methadone exposure and neonatal outcomes: systematic review and meta-analysis. Am J Epidemiol. 2014 Oct 1; 180(7):673-86.
    View in: PubMed
  2. Griffin PJ, Sebastiani P, Edward H, Baldwin CT, Gladwin MT, Gordeuk VR, Chui DH, Steinberg MH. The genetics of hemoglobin A2 regulation in sickle cell anemia. Am J Hematol. 2014 Nov; 89(11):1019-23.
    View in: PubMed
  3. Milton JN, Gordeuk VR, Taylor JG, Gladwin MT, Steinberg MH, Sebastiani P. Prediction of fetal hemoglobin in sickle cell anemia using an ensemble of genetic risk prediction models. Circ Cardiovasc Genet. 2014 Apr 1; 7(2):110-5.
    View in: PubMed
  4. Zhang X, Zhang W, Ma SF, Desai AA, Saraf S, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Abbasi T, Casanova NG, Steinberg MH, Baldwin CT, Sebastiani P, Prchal JT, Kittles R, Garcia JG, Machado RF, Gordeuk VR. Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. Circulation. 2014 Apr 22; 129(16):1650-8.
    View in: PubMed
  5. H. T. Bae,T. T. Perls, M. H. Steinberg, P. Sebastiani . Bayesian polynomial regression models to fit multiple genetic models for quantitative traits. Bayesian Analysis Journal. 2014.
  6. P. Sebastiani, S. L. Andersen, A. I. McIntosh, L. Nussbaum, M D Stevenson, L Pierce, S.Xia, K. Salance, and T. T. Perls . Contribution of Familial Longevity to Living to 100. 2014 Living to 100 Monograph. 2014.
  7. Alsultan A, Alabdulaali MK, Griffin PJ, Alsuliman AM, Ghabbour HA, Sebastiani P, Albuali WH, Al-Ali AK, Chui DH, Steinberg MH. Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab-Indian haplotype is not benign. Br J Haematol. 2014 Feb; 164(4):597-604.
    View in: PubMed
  8. Steinberg MH, Chui DH, Dover GJ, Sebastiani P, Alsultan A. Fetal hemoglobin in sickle cell anemia: a glass half full? Blood. 2014 Jan 23; 123(4):481-5.
    View in: PubMed
  9. Baranoski AS, Harris A, Michaels D, Miciek R, Storer T, Sebastiani P, Montano M. Relationship Between Poor Physical Function, Inflammatory Markers, and Comorbidities in HIV-Infected Women on Antiretroviral Therapy. J Womens Health (Larchmt). 2014 Jan; 23(1):69-76.
    View in: PubMed
  10. Sebastiani P, Sun FX, Andersen SL, Lee JH, Wojczynski MK, Sanders JL, Yashin A, Newman AB, Perls TT. Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study. Front Public Health. 2013; 1:38.
    View in: PubMed
  11. Sebastiani P, Bae H, Sun FX, Andersen SL, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A, Perls TT. Meta-analysis of genetic variants associated with human exceptional longevity. Aging (Albany NY). 2013 Sep; 5(9):653-61.
    View in: PubMed
  12. Elo IT, Mykyta L, Sebastiani P, Christensen K, Glynn NW, Perls T. Age validation in the long life family study through a linkage to early-life census records. J Gerontol B Psychol Sci Soc Sci. 2013 Jul; 68(4):580-5.
    View in: PubMed
  13. Bae HT, Sebastiani P, Sun JX, Andersen SL, Daw EW, Terracciano A, Ferrucci L, Perls TT. Genome-wide association study of personality traits in the long life family study. Front Genet. 2013; 4:65.
    View in: PubMed
  14. Alsultan A, Ngo D, Bae H, Sebastiani P, Baldwin CT, Melista E, Suliman AM, Albuali WH, Nasserullah Z, Luo HY, Chui DH, Steinberg MH, Al-Ali AK. Genetic studies of fetal hemoglobin in the Arab-Indian haplotype sickle cell-ß(0) thalassemia. Am J Hematol. 2013 Jun; 88(6):531-2.
    View in: PubMed
  15. Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med. 2013 May 1; 187(9):933-42.
    View in: PubMed
  16. Friedman R, Kudesia V, Sebastiani P, Monti S, Misquitta D, Peterson K, Whinfield J, Stoeckle R. Educating translational researchers in research informatics principles and methods: an evaluation of a model online course and plans for its dissemination. AMIA Summits Transl Sci Proc. 2013; 2013:59.
    View in: PubMed
  17. Ngo D, Bae H, Steinberg MH, Sebastiani P, Solovieff N, Baldwin CT, Melista E, Safaya S, Farrer LA, Al-Suliman AM, Albuali WH, Al Bagshi MH, Naserullah Z, Akinsheye I, Gallagher P, Luo HY, Chui DH, Farrell JJ, Al-Ali AK, Alsultan A. Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype. Blood Cells Mol Dis. 2013 Jun; 51(1):22-6.
    View in: PubMed
  18. Hartley SW, Sebastiani P. PleioGRiP: genetic risk prediction with pleiotropy. Bioinformatics. 2013 Apr 15; 29(8):1086-8.
    View in: PubMed
  19. Milton JN, Rooks H, Drasar E, McCabe EL, Baldwin CT, Melista E, Gordeuk VR, Nouraie M, Kato GR, Minniti C, Taylor J, Campbell A, Luchtman-Jones L, Rana S, Castro O, Zhang Y, Thein SL, Sebastiani P, Gladwin MT. Genetic determinants of haemolysis in sickle cell anaemia. Br J Haematol. 2013 Apr; 161(2):270-8.
    View in: PubMed
  20. P. Sebastiani, H. Bae, A. McIntosh, S. Monti . Bayesian Graphical Models for Gene-Environment Interaction. Proceedings of the JSM, 2013. 2013.
  21. Andersen SL, Sun JX, Sebastiani P, Huntly J, Gass JD, Feldman L, Bae H, Christiansen L, Perls TT. Personality factors in the Long Life Family Study. J Gerontol B Psychol Sci Soc Sci. 2013 Sep; 68(5):739-49.
    View in: PubMed
  22. Sebastiani P, Perls TT. The genetics of extreme longevity: lessons from the new England centenarian study. Front Genet. 2012; 3:277.
    View in: PubMed
  23. Sturiale CL, Puca A, Sebastiani P, Gatto I, Albanese A, Di Rocco C, Maira G, Pola R. Single nucleotide polymorphisms associated with sporadic brain arteriovenous malformations: where do we stand? Brain. 2013 Feb; 136(Pt 2):665-81.
    View in: PubMed
  24. Hartley SW, Monti S, Liu CT, Steinberg MH, Sebastiani P. Bayesian methods for multivariate modeling of pleiotropic SNP associations and genetic risk prediction. Front Genet. 2012; 3:176.
    View in: PubMed
  25. Bae HT, Baldwin CT, Sebastiani P, Telen MJ, Ashley-Koch A, Garrett M, Hooper WC, Bean CJ, Debaun MR, Arking DE, Bhatnagar P, Casella JF, Keefer JR, Barron-Casella E, Gordeuk V, Kato GJ, Minniti C, Taylor J, Campbell A, Luchtman-Jones L, Hoppe C, Gladwin MT, Zhang Y, Steinberg MH. Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans. Blood. 2012 Aug 30; 120(9):1961-2.
    View in: PubMed
  26. Banerjee C, Archin N, Michaels D, Belkina AC, Denis GV, Bradner J, Sebastiani P, Margolis DM, Montano M. BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol. 2012 Dec; 92(6):1147-54.
    View in: PubMed
  27. Kusko RL, Banerjee C, Long KK, Darcy A, Otis J, Sebastiani P, Melov S, Tarnopolsky M, Bhasin S, Montano M. Premature expression of a muscle fibrosis axis in chronic HIV infection. Skelet Muscle. 2012; 2(1):10.
    View in: PubMed
  28. Steinberg MH, Sebastiani P. Genetic modifiers of sickle cell disease. Am J Hematol. 2012 Aug; 87(8):795-803.
    View in: PubMed
  29. Milton JN, Sebastiani P, Solovieff N, Hartley SW, Bhatnagar P, Arking DE, Dworkis DA, Casella JF, Barron-Casella E, Bean CJ, Hooper WC, DeBaun MR, Garrett ME, Soldano K, Telen MJ, Ashley-Koch A, Gladwin MT, Baldwin CT, Steinberg MH, Klings ES. A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. PLoS One. 2012; 7(4):e34741.
    View in: PubMed
  30. Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS. Human longevity and common variations in the LMNA gene: a meta-analysis. Aging Cell. 2012 Jun; 11(3):475-81.
    View in: PubMed
  31. Sebastiani P, Solovieff N, Sun JX. Naïve Bayesian Classifier and Genetic Risk Score for Genetic Risk Prediction of a Categorical Trait: Not so Different after all! Front Genet. 2012; 3:26.
    View in: PubMed
  32. Paola Sebastiani, Nadia Solovieff, Andrew T DeWan, Kyle M Walsh, Annibale Puca, Stephen W Hartley, Efthymia Melista, Stacy Andersen, Daniel A Dworkis, Jemma B Wilk, Richard H Myers, Martin H Steinberg, Monty Montano, Clinton T Baldwin, Josephine Hoh, Thomas T Perls. Genetic signatures of exceptional longevity in humans. PLoS ONE. 2012; 7.
    View in: External Website
  33. Sebastiani P, Solovieff N, Dewan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. Genetic signatures of exceptional longevity in humans. PLoS One. 2012; 7(1):e29848.
    View in: PubMed
  34. Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls TT. Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. J Gerontol A Biol Sci Med Sci. 2012 Apr; 67(4):395-405.
    View in: PubMed
  35. P Sebastiani, A Riva, M Montano, P Pham, T Torkamani, E Scherba, G Benson, JN Milton, CT Baldwin, S Andersen, NJ Schork, MJ Steinberg, TT Perls. Whole genome sequences of a male and female supercentenarian, ages greater than 114 years. 2012.
    View in: External Website
  36. Sebastiani P, Riva A, Montano M, Pham P, Torkamani A, Scherba E, Benson G, Milton JN, Baldwin CT, Andersen S, Schork NJ, Steinberg MH, Perls TT. Whole genome sequences of a male and female supercentenarian, ages greater than 114?years. Front Genet. 2011; 2:90.
    View in: PubMed
  37. Akinsheye I, Solovieff N, Ngo D, Malek A, Sebastiani P, Steinberg MH, Chui DH. Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans. Am J Hematol. 2012 Feb; 87(2):217-9.
    View in: PubMed
  38. Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Retraction. Science. 2011 Jul 22; 333(6041):404.
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  39. Banerjee C, Ulloor J, Dillon EL, Dahodwala Q, Franklin B, Storer T, Sebastiani P, Sheffield-Moore M, Urban RJ, Bhasin S, Montano M. Identification of serum biomarkers for aging and anabolic response. Immun Ageing. 2011; 8(1):5.
    View in: PubMed
  40. Solovieff N, Hartley SW, Baldwin CT, Klings ES, Gladwin MT, Taylor JG, Kato GJ, Farrer LA, Steinberg MH, Sebastiani P. Ancestry of African Americans with sickle cell disease. Blood Cells Mol Dis. 2011 Jun 15; 47(1):41-5.
    View in: PubMed
  41. Akinsheye I, Alsultan A, Solovieff N, Ngo D, Baldwin CT, Sebastiani P, Chui DH, Steinberg MH. Fetal hemoglobin in sickle cell anemia. Blood. 2011 Jul 7; 118(1):19-27.
    View in: PubMed
  42. Farrell JJ, Sherva RM, Chen ZY, Luo HY, Chu BF, Ha SY, Li CK, Lee AC, Li RC, Li CK, Yuen HL, So JC, Ma ES, Chan LC, Chan V, Sebastiani P, Farrer LA, Baldwin CT, Steinberg MH, Chui DH. A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression. Blood. 2011 May 5; 117(18):4935-45.
    View in: PubMed
  43. Hannafon BN, Sebastiani P, de las Morenas A, Lu J, Rosenberg CL. Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer. Breast Cancer Res. 2011; 13(2):R24.
    View in: PubMed
  44. Dworkis DA, Klings ES, Solovieff N, Li G, Milton JN, Hartley SW, Melista E, Parente J, Sebastiani P, Steinberg MH, Baldwin CT. Severe sickle cell anemia is associated with increased plasma levels of TNF-R1 and VCAM-1. Am J Hematol. 2011 Feb; 86(2):220-3.
    View in: PubMed
  45. Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R, Christensen K, Zmuda JM, Barral S, Lee JH, Simonsick EM, Walston JD, Yashin AI, Hadley E. Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging (Albany NY). 2011 Jan; 3(1):63-76.
    View in: PubMed
  46. Solovieff N, Hartley SW, Baldwin CT, Perls TT, Steinberg MH, Sebastiani P. Clustering by genetic ancestry using genome-wide SNP data. BMC Genet. 2010; 11:108.
    View in: PubMed
  47. Minniti CP, Eckman J, Sebastiani P, Steinberg MH, Ballas SK. Leg ulcers in sickle cell disease. Am J Hematol. 2010 Oct; 85(10):831-3.
    View in: PubMed
  48. Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Genetic signatures of exceptional longevity in humans. Science. 2010 Jul 1; 2010.
    View in: PubMed
  49. Graham K, de las Morenas A, Tripathi A, King C, Kavanah M, Mendez J, Stone M, Slama J, Miller M, Antoine G, Willers H, Sebastiani P, Rosenberg CL. Gene expression in histologically normal epithelium from breast cancer patients and from cancer-free prophylactic mastectomy patients shares a similar profile. Br J Cancer. 2010 Apr 13; 102(8):1284-93.
    View in: PubMed
  50. Sebastiani P, Perls TT. Prediction models that include genetic data. Circ Cardiovasc Genet. 2010 Feb; 3(1):1-2.
    View in: PubMed
  51. Sebastiani P, Solovieff N, Hartley SW, Milton JN, Riva A, Dworkis DA, Melista E, Klings ES, Garrett ME, Telen MJ, Ashley-Koch A, Baldwin CT, Steinberg MH. Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. Am J Hematol. 2010 Jan; 85(1):29-35.
    View in: PubMed
  52. Solovieff N, Milton JN, Hartley SW, Sherva R, Sebastiani P, Dworkis DA, Klings ES, Farrer LA, Garrett ME, Ashley-Koch A, Telen MJ, Fucharoen S, Ha SY, Li CK, Chui DH, Baldwin CT, Steinberg MH. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. Blood. 2010 Mar 4; 115(9):1815-22.
    View in: PubMed
  53. Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009; 4(12):e8210.
    View in: PubMed
  54. Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol Genomics. 2010 Mar 3; 41(1):1-8.
    View in: PubMed
  55. Sebastiani P, Hadley EC, Province M, Christensen K, Rossi W, Perls TT, Ash AS. A family longevity selection score: ranking sibships by their longevity, size, and availability for study. Am J Epidemiol. 2009 Dec 15; 170(12):1555-62.
    View in: PubMed
  56. Emery LA, Tripathi A, King C, Kavanah M, Mendez J, Stone MD, de las Morenas A, Sebastiani P, Rosenberg CL. Early dysregulation of cell adhesion and extracellular matrix pathways in breast cancer progression. Am J Pathol. 2009 Sep; 175(3):1292-302.
    View in: PubMed
  57. Sebastiani P, Timofeev N, Dworkis DA, Perls TT, Steinberg MH. Genome-wide association studies and the genetic dissection of complex traits. Am J Hematol. 2009 Aug; 84(8):504-15.
    View in: PubMed
  58. Bais M, McLean J, Sebastiani P, Young M, Wigner N, Smith T, Kotton DN, Einhorn TA, Gerstenfeld LC. Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. PLoS One. 2009; 4(5):e5393.
    View in: PubMed
  59. Gerhardinger C, Dagher Z, Sebastiani P, Park YS, Lorenzi M. The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy. Diabetes. 2009 Jul; 58(7):1659-67.
    View in: PubMed
  60. Givens JL, Frederick M, Silverman L, Anderson S, Senville J, Silver M, Sebastiani P, Terry DF, Costa PT, Perls TT. Personality traits of centenarians' offspring. J Am Geriatr Soc. 2009 Apr; 57(4):683-5.
    View in: PubMed
  61. Zhao Z, Timofeev N, Hartley SW, Chui DH, Fucharoen S, Perls TT, Steinberg MH, Baldwin CT, Sebastiani P. Imputation of missing genotypes: an empirical evaluation of IMPUTE. BMC Genet. 2008; 9:85.
    View in: PubMed
  62. Nolan VG, Zhang Y, Lash T, Sebastiani P, Steinberg MH. Association between wind speed and the occurrence of sickle cell acute painful episodes: results of a case-crossover study. Br J Haematol. 2008 Nov; 143(3):433-8.
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  63. Sedgewick AE, Timofeev N, Sebastiani P, So JC, Ma ES, Chan LC, Fucharoen G, Fucharoen S, Barbosa CG, Vardarajan BN, Farrer LA, Baldwin CT, Steinberg MH, Chui DH. BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies. Blood Cells Mol Dis. 2008 Nov-Dec; 41(3):255-8.
    View in: PubMed
  64. Beane J, Sebastiani P, Whitfield TH, Steiling K, Dumas YM, Lenburg ME, Spira A. A prediction model for lung cancer diagnosis that integrates genomic and clinical features. Cancer Prev Res (Phila). 2008 Jun; 1(1):56-64.
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  65. Wang L, Montano M, Rarick M, Sebastiani P. Conditional clustering of temporal expression profiles. BMC Bioinformatics. 2008; 9:147.
    View in: PubMed
  66. Sebastiani P, Wang L, Nolan VG, Melista E, Ma Q, Baldwin CT, Steinberg MH. Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations. Am J Hematol. 2008 Mar; 83(3):189-95.
    View in: PubMed
  67. Terry DF, Sebastiani P, Andersen SL, Perls TT. Disentangling the roles of disability and morbidity in survival to exceptional old age. Arch Intern Med. 2008 Feb 11; 168(3):277-83.
    View in: PubMed
  68. Abad-Grau MM, Ierache J, Cervino C, Sebastiani P. Evolution and challenges in the design of computational systems for triage assistance. J Biomed Inform. 2008 Jun; 41(3):432-41.
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  69. Sebastiani P, Zhao Z, Abad-Grau MM, Riva A, Hartley SW, Sedgewick AE, Doria A, Montano M, Melista E, Terry D, Perls TT, Steinberg MH, Baldwin CT. A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples. BMC Genet. 2008; 9:6.
    View in: PubMed
  70. Sebastiani P, Nolan VG, Baldwin CT, Abad-Grau MM, Wang L, Adewoye AH, McMahon LC, Farrer LA, Taylor JG, Kato GJ, Gladwin MT, Steinberg MH. A network model to predict the risk of death in sickle cell disease. Blood. 2007 Oct 1; 110(7):2727-35.
    View in: PubMed
  71. Sebastiani P, Abad-Grau MM. Bayesian estimates of linkage disequilibrium. BMC Genet. 2007; 8:36.
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  72. Ferrazzi F, Sebastiani P, Ramoni MF, Bellazzi R. Bayesian approaches to reverse engineer cellular systems: a simulation study on nonlinear Gaussian networks. BMC Bioinformatics. 2007; 8 Suppl 5:S2.
    View in: PubMed
  73. Montano M, Flanagan JN, Jiang L, Sebastiani P, Rarick M, LeBrasseur NK, Morris CA, Jasuja R, Bhasin S. Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul; 92(7):2793-802.
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  74. Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, Keane J, Lenburg ME, Brody JS. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med. 2007 Mar; 13(3):361-6.
    View in: PubMed
  75. Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME, Spira A. Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biol. 2007; 8(9):R201.
    View in: PubMed
  76. Abad-Grau MM, Montes R, Sebastiani P. Building chromosome-wide LD maps. Bioinformatics. 2006 Aug 15; 22(16):1933-4.
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  77. Sebastiani P, Mandl KD, Szolovits P, Kohane IS, Ramoni MF. A Bayesian dynamic model for influenza surveillance. Stat Med. 2006 Jun 15; 25(11):1803-16; discussion 1817-25.
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  78. Nolan VG, Adewoye A, Baldwin C, Wang L, Ma Q, Wyszynski DF, Farrell JJ, Sebastiani P, Farrer LA, Steinberg MH. Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway. Br J Haematol. 2006 Jun; 133(5):570-8.
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  79. Montano M, Rarick M, Sebastiani P, Brinkmann P, Russell M, Navis A, Wester C, Thior I, Essex M. Gene-expression profiling of HIV-1 infection and perinatal transmission in Botswana. Genes Immun. 2006 Jun; 7(4):298-309.
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  80. Rarick M, McPheeters C, Bright S, Navis A, Skefos J, Sebastiani P, Montano M. Evidence for cross-regulated cytokine response in human peripheral blood mononuclear cells exposed to whole gonococcal bacteria in vitro. Microb Pathog. 2006 Jun; 40(6):261-70.
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  81. Sebastiani P, Xie X, Ramoni MF. Bayesian analysis of comparative microarray experiments by model averaging. Bayesian analysis. 2006; 1(4):707-732.
    View in: External Website
  82. Montano M, Rarick M, Sebastiani P, Brinkmann P, Skefos J, Ericksen R. HIV-1 burden influences host response to co-infection with Neisseria gonorrhoeae in vitro. Int Immunol. 2006 Jan; 18(1):125-37.
    View in: PubMed
  83. Wang L, Ramoni MF, Mandl KD, Sebastiani P. Factors affecting automated syndromic surveillance. Artif Intell Med. 2005 Jul; 34(3):269-78.
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  84. Baldwin C, Nolan VG, Wyszynski DF, Ma QL, Sebastiani P, Embury SH, Bisbee A, Farrell J, Farrer L, Steinberg MH. Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. Blood. 2005 Jul 1; 106(1):372-5.
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  85. Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH. Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia. Nat Genet. 2005 Apr; 37(4):435-40.
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  86. Klings ES, Safaya S, Adewoye AH, Odhiambo A, Frampton G, Lenburg M, Gerry N, Sebastiani P, Steinberg MH, Farber HW. Differential gene expression in pulmonary artery endothelial cells exposed to sickle cell plasma. Physiol Genomics. 2005 May 11; 21(3):293-8.
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  87. Sebastiani P, Ramoni F. Journal of Multivariate analysis. Normative selection of Bayesian networks. 2005; 93(2):340-357.
    View in: External Website
  88. Sebastiani P, Abad MM, Alpargu G, Ramoni MF. Robust transmission/disequilibrium test for incomplete family genotypes. Genetics. 2004 Dec; 168(4):2329-37.
    View in: PubMed
  89. Sebastiani P, Yu YH, Ramoni MF. Bayesian machine learning and its potential applications to the genomic study of oral oncology. Adv Dent Res. 2003 Dec; 17:104-8.
    View in: PubMed
  90. Mandl KD, Overhage JM, Wagner MM, Lober WB, Sebastiani P, Mostashari F, Pavlin JA, Gesteland PH, Treadwell T, Koski E, Hutwagner L, Buckeridge DL, Aller RD, Grannis S. Implementing syndromic surveillance: a practical guide informed by the early experience. J Am Med Inform Assoc. 2004 Mar-Apr; 11(2):141-50.
    View in: PubMed
  91. Sebastiani P, Lazarus R, Weiss ST, Kunkel LM, Kohane IS, Ramoni MF. Minimal haplotype tagging. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9900-5.
    View in: PubMed
  92. P Sebastiani, E Gussoni, IS Kohane, MF Ramoni. Statistical challenges in functional genomics. Statistical Science. 2003; 1(18):33-70.
    View in: External Website
  93. Ramoni MF, Sebastiani P, Kohane IS. Cluster analysis of gene expression dynamics. Proc Natl Acad Sci U S A. 2002 Jul 9; 99(14):9121-6.
    View in: PubMed
  94. Ramoni M, Sebastiani P, Dybowski R. Robust outcome prediction for intensive-care patients. Methods Inf Med. 2001 Mar; 40(1):39-45.
    View in: PubMed
  95. Ramoni MF and Sebastiani P. Robust learning with missing data. Machine Learning. 2001; 45(2):147-170.
    View in: External Website
  96. Ramoni MF and Sebastiani P. Robust Bayes Classifiers. Artificial Intelligence. 2001; 125(1):209-226.
    View in: External Website
  97. Sebastiani P and Ramoni MF. Bayesian selection of decomposable models with incomplete data. Journal of the American Statistical Association. 2001; 96(456):1375-1386.
    View in: External Website
  98. Sebastiani P and Wynn HP. Maximum entropy sampling and optimal Bayesian experimental design. Journal of the Royal Statistical Society: Series B. 2000; 62(1).
    View in: External Website
  99. Dawid AP and Sebastiani P. Coherent dispersion criteria for optimal experimental design. Annals of Statistics. 1999; 65-81.
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  100. Eaton M, Giovagnoli A and Sebastiani P. A predictive approach to the Bayesian design problem with application to normal regression models. Biometrika. 1996; 83(1):111-125.
    View in: External Website
  101. Burridge J and Sebastiani P. D-optimal designs for generalised linear models with variance proportional to the square of the mean. Biometrika. 1994; 81(2):295-304.
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