Paola Sebastiani | Profiles RNS

Paola Sebastiani, PhD

Adjunct Professor

Boston University School of Public Health

Biostatistics

PhD, University of Rome
MSc, University College London (UCL)
BSc, University of Perugia

Websites

	School of Public Health Faculty
	Google Scholar
	LinkedIn
	ResearchGate

ORCID : 0000-0001-6419-1545

Paola Sebastiani, Ph.D. joined the Department of Biostatistics in 2003 as an Associate Professor, after holding faculty positions in Italy, England and United States. She is author of more than 200 peer-reviewed publications in theoretical and methodological statistics, artificial intelligence, computational biology and genetics. She is statistical consultant for Circulation and also a regular reviewer for major journals in statistics and computer science, and serves on the program committee of several international conferences at the interface between statistics and artificial intelligence. When she joined the Department of Biostatistics at Boston University in 2003, Dr. Sebastiani had experience in interdisciplinary collaborations and a track record of developing novel methodologies in Bayesian statistics, machine learning, decision theory, graphical modeling and statistical experimental design. She leveraged this experience to develop a wide network of collaborations with investigators from the Bioinformatics program, the Genetics and Genomics program, and the Molecular and Translational Medicine Program. In these collaborations Dr. Sebastiani often introduced original solutions by developing innovative Bayesian techniques for the analysis of genomic and genetic data and for the joint modeling of the genetic, genomic and phenotypic basis of complex traits. This work has been supported by the National Science Foundation and the National Institutes for Health and is currently funded by grants of which Dr. Sebastiani is Principal Investigator. Her contributions include, among others, a Bayesian model-based clustering procedure of temporal expression profiles (CAGED), a robust Bayesian approach to analyze differential gene expression using model averaging (BADGE), and novel methods for analysis of genetic data. Dr. Sebastiani was a pioneer in using a Bayesian network approach to model the genetic and phenotypic basis of complications of sickle cell anemia. She developed the first network model for predicting stroke in patients with sickle cell anemia and a network-based prognostic model that integrates sub-phenotypes of sickle cell anemia patients into a score of the overall severity of disease. This model was successfully evaluated by independent investigators and has opened several new research areas in sickle cell disease. These results were the fruit of a long and productive collaboration with Dr. Steinberg to study the genetic basis of different clinical presentations of sickle cell disease.

Dr. Sebastiani has also cultivated a strong and growing reputation as a biostatistician in the fields of gerontology, biology and epidemiology of human aging and longevity. She is the primary statistician of the BU site of the Long Life Family Study, and of the New England Centenarian Study directed by Dr. Thomas Perls. Dr. Sebastiani used an original Bayesian approach to verify the “compression of morbidity hypothesis” that had long been debated in the field of gerontology, developed a method for scoring sibships for familial longevity that can be used to enroll the most informative families in observational studies of human longevity, and introduced a novel Bayesian approach to model the genetic and phenotypic basis of exceptional human longevity. The analysis provides evidence that extreme human longevity is not due to absence of disease variants but to rare combinations of large numbers of common protective variants. Her current work focuses on the generation of molecular profiles to predict patterns of aging, and the biology of aging using a system-based approach.

Member
Boston University
BU-BMC Cancer Center

Investigator
Framingham Heart Study

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Boston Medical Center

Member
Boston University
Bioinformatics Graduate Program

Member
Boston University
Genome Science Institute

BU Research
NIH RePORTER Research

Candidate protective factors for age-associated diseases (target discovery) or factors indicative of healthy aging
09/15/2016 - 09/15/2024 (PI)
Novartis Institutes for BioMedical Research

Long Life Family Study: Boston Field Center
08/15/2019 - 03/31/2024 (Subcontract PI)
University of Washington NIH NIA
1U19AG063893-01

Longevity Consortium
09/30/2018 - 05/31/2023 (Subcontract PI)
Sutter Bay Hospitals dba California Pacific Medical Center NIH NIA
5U19AG023122-12

Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies
09/15/2019 - 06/30/2022 (Multi PI of Sub-Project / SP)
PI: Thomas T. Perls, MD, MPH, FACP
NIH/National Institute on Aging
5UH2AG064704-02

New England Centenarian Study
07/01/2016 - 06/30/2022 (Multi-PI)
PI: Paola Sebastiani, PhD
The William M. Wood Foundation

Interdisciplinary Training for Biostatisticians
07/01/2015 - 08/31/2020 (PI of Sub-Project / SP)
PI: Laura Forsberg White, PhD
NIH/National Institute of General Medical Sciences
5T32GM074905-15

Boston OAIC: A Translational Approach to Function Promoting Therapies
07/01/2016 - 06/30/2020 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
5P30AG031679-09

Protein signatures of APOE and cognitive aging
09/30/2018 - 05/31/2020 (PI)
NIH/National Institute on Aging
5R01AG061844-02

APOE Alleles and Extreme Human Longevity
09/15/2017 - 05/31/2020 (PI)
NIH/National Institute on Aging
5R21AG056630-02

The Long Life Family Study
06/01/2014 - 07/31/2019 (Subcontract PI)
Boston Medical Center Corporation NIH NIA
5U01AG023755-13

Showing 10 of 21 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2023	Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies	5UH3AG064704-04
2023	Analysis Methods Core	5U19AG063893-05-6292
2022	Analysis Methods Core	5U19AG063893-04-6292
2022	Protein Signatures of APOE2 and Cognitive Aging	5R01AG061844-05
2021	Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies	3UH2AG064704-02S1
2021	Analysis Methods Core	5U19AG063893-03-6292
2021	Protein Signatures of APOE2 and Cognitive Aging	5R01AG061844-04	3
2021	Protein Signatures of APOE2 and Cognitive Aging	3R01AG061844-04S1	3
2020	Identifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategies	5UH2AG064704-02
2020	Protein Signatures of APOE2 and Cognitive Aging	7R01AG061844-03	3

Showing 10 of 31 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Reed ER, Chandler KB, Lopez P, Costello CE, Andersen SL, Perls TT, Li M, Bae H, Soerensen M, Monti S, Sebastiani P. Cross-platform proteomics signatures of extreme old age. Geroscience. 2024 Jul 25.View Related Profiles.

Costello, Catherine
Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 39048883

Matz J, Gonzalez MP, Niedbalski P, Kim H, Chen Y, Sebastiani P, Gollner MJ, Bellini C, Oakes JM. Assessment of Left Lung Remodeling With Magnetic Resonance Imaging in a Murine Model Following Exposure to Douglas Fir Smoke. J Biomech Eng. 2024 Jul 01; 146(7). PMID: 38581378; PMCID: PMC11080952; DOI: 10.1115/1.4065272;

Li M, Song Z, Gurinovich A, Schork N, Sebastiani P, Monti S. yQTL Pipeline: A structured computational workflow for large scale quantitative trait loci discovery and downstream visualization. PLoS One. 2024; 19(6):e0298501.View Related Profiles.

Sebastiani, Paola
Monti, Stefano

PMID: 38833463; PMCID: PMC11149833; DOI: 10.1371/journal.pone.0298501;

Liu A, Jacobs-McFarlane C, Sebastiani P, Glassberg J, McCuskee S, Curtis S. Plasma free hemoglobin is associated with LDH, AST, total bilirubin, reticulocyte count, and the hemolysis score in patients with sickle cell anemia. Res Sq. 2024 May 02. PMID: 38746469; PMCID: PMC11092852; DOI: 10.21203/rs.3.rs-4252554/v1;

Reed ER, Chandler KB, Lopez P, Costello CE, Andersen SL, Perls TT, Li M, Bae H, Soerensen M, Monti S, Sebastiani P. Cross-platform proteomics signatures of extreme old age. bioRxiv. 2024 Apr 14.View Related Profiles.

Costello, Catherine
Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 38645061; PMCID: PMC11030369; DOI: 10.1101/2024.04.10.588876;

Song Z, Gunn S, Monti S, Peloso GM, Liu CT, Lunetta K, Sebastiani P. Learning Gaussian Graphical Models from Correlated Data. bioRxiv. 2024 Apr 05.View Related Profiles.

Liu, Ching-Ti
Peloso, Gina
Lunetta, Kathryn
Sebastiani, Paola
Monti, Stefano

PMID: 38617340; PMCID: PMC11014549; DOI: 10.1101/2024.04.03.587948;

Dowrey TW, Cranston SF, Skvir N, Lok Y, Gould B, Petrowitz B, Villar D, Shan J, James M, Dodge M, Belkina AC, Giadone RM, Sebastiani P, Perls TT, Andersen SL, Murphy GJ. A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring. bioRxiv. 2024 Mar 14.View Related Profiles.

Belkina, Anna
Murphy, George
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 38559230; PMCID: PMC10979955; DOI: 10.1101/2024.03.12.584663;

Don J, Schork AJ, Glusman G, Rappaport N, Cummings SR, Duggan D, Raju A, Hellberg KG, Gunn S, Monti S, Perls T, Lapidus J, Goetz LH, Sebastiani P, Schork NJ. The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank. Geroscience. 2024 Aug; 46(4):3911-3927.View Related Profiles.

Sebastiani, Paola
Monti, Stefano
Perls, Thomas

PMID: 38451433; PMCID: PMC11226417; DOI: 10.1007/s11357-024-01107-1;

Patel R, Cosentino S, Zheng EZ, Schupf N, Barral S, Feitosa M, Andersen SL, Sebastiani P, Ukraintseva S, Christensen K, Zmuda J, Thyagarajan B, Gu Y. Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS). Brain Behav Immun Health. 2024 May; 37:100746.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy

PMID: 38476338; PMCID: PMC10925922; DOI: 10.1016/j.bbih.2024.100746;

Li M, Song Z, Gurinovich A, Schork N, Sebastiani P, Monti S. yQTL Pipeline: a structured computational workflow for large scale quantitative trait loci discovery and downstream visualization. bioRxiv. 2024 Jan 30.View Related Profiles.

Sebastiani, Paola
Monti, Stefano

PMID: 38370654; PMCID: PMC10874520; DOI: 10.1101/2024.01.26.577518;

Showing 10 of 279 results. Show More

Ardisson Korat AV, Shea MK, Jacques PF, Sebastiani P, Wang M, Eliassen AH, Willett WC, Sun Q. Dietary protein intake in midlife in relation to healthy aging - results from the prospective Nurses' Health Study cohort. Am J Clin Nutr. 2024 Feb; 119(2):271-282. PMID: 38309825; PMCID: PMC10884611; DOI: 10.1016/j.ajcnut.2023.11.010;

Reed E, Sebastiani P. A Simple Strategy for Identifying Conserved Features across Non-independent Omics Studies. bioRxiv. 2023 Nov 23. PMID: 38045352; PMCID: PMC10690236; DOI: 10.1101/2023.11.22.568276;

Leshchyk A, Xiang Q, Andersen SL, Gurinovich A, Song Z, Lee JH, Christensen K, Yashin A, Wojczynski M, Schwander K, Perls TT, Monti S, Sebastiani P. Mosaic Chromosomal Alterations and Human Longevity. J Gerontol A Biol Sci Med Sci. 2023 Aug 27; 78(9):1561-1568.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 36988570; PMCID: PMC10460554; DOI: 10.1093/gerona/glad095;

Karagiannis TT, Monti S, Sebastiani P. Bayesian differential analysis of cell type proportions: opinion. Front Genet. 2023; 14:1205499.View Related Profiles.

Sebastiani, Paola
Monti, Stefano

PMID: 37323674; PMCID: PMC10267376; DOI: 10.3389/fgene.2023.1205499;

Karagiannis TT, Dowrey TW, Villacorta-Martin C, Montano M, Reed E, Belkina AC, Andersen SL, Perls TT, Monti S, Murphy GJ, Sebastiani P. Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity. EBioMedicine. 2023 Apr; 90:104514.View Related Profiles.

Belkina, Anna
Murphy, George
Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 37005201; PMCID: PMC10114155; DOI: 10.1016/j.ebiom.2023.104514;

Leshchyk A, Xiang Q, Andersen SL, Gurinovich A, Song Z, Lee JH, Christensen K, Yashin A, Wojczynski M, Schwander K, Perls TT, Monti S, Sebastiani P. Mosaic chromosomal alterations and human longevity. J Gerontol A Biol Sci Med Sci. 2023 Mar 29.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 36988570; PMCID: PMC10460554; DOI: 10.1093/gerona/glad095;

Song Z, Gurinovich A, Nygaard M, Mengel-From J, Andersen S, Cosentino S, Schupf N, Lee J, Zmuda J, Ukraintseva S, Arbeev K, Christensen K, Perls T, Sebastiani P. Rare genetic variants correlate with better processing speed. Neurobiol Aging. 2023 May; 125:115-122.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 36813607; PMCID: PMC10038891; DOI: 10.1016/j.neurobiolaging.2022.11.018;

Karagiannis TT, Monti S, Sebastiani P. Bayesian Differential Analysis of Cell Type Proportions. bioRxiv. 2023 Jan 19.View Related Profiles.

Sebastiani, Paola
Monti, Stefano

PMID: 36712131; PMCID: PMC9882175; DOI: 10.1101/2023.01.17.524410;

Xiang Q, Andersen SL, Sweigart B, Gunn S, Nygaard M, Perls TT, Sebastiani P. Signatures of Neuropsychological Test Results in the Long Life Family Study: A Cluster Analysis. J Alzheimers Dis. 2023; 93(4):1457-1469.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 37212095; PMCID: PMC10635779; DOI: 10.3233/JAD-221025;

Bae H, Gurinovich A, Karagiannis TT, Song Z, Leshchyk A, Li M, Andersen SL, Arbeev K, Yashin A, Zmuda J, An P, Feitosa M, Giuliani C, Franceschi C, Garagnani P, Mengel-From J, Atzmon G, Barzilai N, Puca A, Schork NJ, Perls TT, Sebastiani P. A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants. Int J Mol Sci. 2022 Dec 21; 24(1).View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 36613555; PMCID: PMC9820206; DOI: 10.3390/ijms24010116;

Sebastiani P, Steinberg MH. Fetal hemoglobin per erythrocyte (HbF/F-cell) after gene therapy for sickle cell anemia. Am J Hematol. 2023 Feb; 98(2):E32-E34.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola

PMID: 36420999

Shea MK, Korat AVA, Jacques PF, Sebastiani P, Cohen R, LaVertu AE, Booth SL. Leveraging Observational Cohorts to Study Diet and Nutrition in Older Adults: Opportunities and Obstacles. Adv Nutr. 2022 Oct 02; 13(5):1652-1668. PMID: 35362509; PMCID: PMC9526832; DOI: 10.1093/advances/nmac031;

Gurinovich A, Li M, Leshchyk A, Bae H, Song Z, Arbeev KG, Nygaard M, Feitosa MF, Perls TT, Sebastiani P. Evaluation of GENESIS, SAIGE, REGENIE and fastGWA-GLMM for genome-wide association studies of binary traits in correlated data. Front Genet. 2022; 13:897210.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 36212134; PMCID: PMC9544087; DOI: 10.3389/fgene.2022.897210;

Sebastiani P, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Lustgarten MS, Funk CC, Baloni P, Yao CH, Joshi S, Marron MM, Gurinovich A, Li M, Leshchyk A, Xiang Q, Andersen SL, Feitosa MF, Ukraintseva S, Soerensen M, Fiehn O, Ordovas JM, Haigis M, Monti S, Barzilai N, Milman S, Ferrucci L, Rappaport N, Patti GJ, Perls TT. A metabolomic signature of the APOE2 allele. Geroscience. 2023 Feb; 45(1):415-426.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 35997888; PMCID: PMC9886693; DOI: 10.1007/s11357-022-00646-9;

Penney JA, Rodday AM, Sebastiani P, Snydman DR, Doron S. Effecting the culture: Impact of changing urinalysis with reflex to culture criteria on culture rates and outcomes. Infect Control Hosp Epidemiol. 2023 Feb; 44(2):210-215. PMID: 35924370

Leavitt SV, Jenkins HE, Sebastiani P, Lee RS, Horsburgh CR, Tibbs AM, White LF. Estimation of the generation interval using pairwise relative transmission probabilities. Biostatistics. 2022 Jul 18; 23(3):807-824.View Related Profiles.

Jenkins, Helen
White, Laura
Sebastiani, Paola

PMID: 33527996; PMCID: PMC9291635; DOI: 10.1093/biostatistics/kxaa059;

Penney JA, Rodday AM, Sebastiani P, Snydman DR, Doron SI. Impact of provider-selected indication requirement on urine test utilization and positivity. Antimicrob Steward Healthc Epidemiol. 2022; 2(1):e103. PMID: 36483372; PMCID: PMC9726588; DOI: 10.1017/ash.2022.243;

Barral S, Andersen SL, Perls TT, Bae H, Sebastiani P, Christensen K, Thyagarajan B, Lee J, Schupf N. Association between late maternal age and age-related endophenotypes in the Long Life Family Study. Neurosci Lett. 2022 Jul 27; 784:136737.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 35709880; PMCID: PMC11061875; DOI: 10.1016/j.neulet.2022.136737;

Wilmanski T, Kornilov SA, Diener C, Conomos MP, Lovejoy JC, Sebastiani P, Orwoll ES, Hood L, Price ND, Rappaport N, Magis AT, Gibbons SM. Heterogeneity in statin responses explained by variation in the human gut microbiome. Med (N Y). 2022 Jun 10; 3(6):388-405.e6. PMID: 35690059; PMCID: PMC9261472; DOI: 10.1016/j.medj.2022.04.007;

Karagiannis TT, Monti S, Sebastiani P. Cell Type Diversity Statistic: An Entropy-Based Metric to Compare Overall Cell Type Composition Across Samples. Front Genet. 2022; 13:855076.View Related Profiles.

Sebastiani, Paola
Monti, Stefano

PMID: 35464841; PMCID: PMC9023789; DOI: 10.3389/fgene.2022.855076;

Wojczynski MK, Jiuan Lin S, Sebastiani P, Perls TT, Lee J, Kulminski A, Newman A, Zmuda JM, Christensen K, Province MA. NIA Long Life Family Study: Objectives, Design, and Heritability of Cross-Sectional and Longitudinal Phenotypes. J Gerontol A Biol Sci Med Sci. 2022 Apr 01; 77(4):717-727.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 34739053; PMCID: PMC8974329; DOI: 10.1093/gerona/glab333;

Du M, Andersen SL, Cosentino S, Boudreau RM, Perls TT, Sebastiani P. Digitally generated Trail Making Test data: Analysis using hidden Markov modeling. Alzheimers Dement (Amst). 2022; 14(1):e12292.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 35280964; PMCID: PMC8902814; DOI: 10.1002/dad2.12292;

Gunn S, Wainberg M, Song Z, Andersen S, Boudreau R, Feitosa MF, Tan Q, Montasser ME, O'Connell JR, Stitziel N, Price N, Perls T, Schork NJ, Sebastiani P. Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring. Geroscience. 2022 Apr; 44(2):719-729.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 35119614; PMCID: PMC9135909; DOI: 10.1007/s11357-022-00518-2;

Fisher V, Sebastiani P, Cupples LA, Liu CT. ANNORE: genetic fine-mapping with functional annotation. Hum Mol Genet. 2021 12 17; 31(1):32-40.View Related Profiles.

Liu, Ching-Ti
Cupples, L
Sebastiani, Paola

PMID: 34302344; PMCID: PMC8682766; DOI: 10.1093/hmg/ddab210;

Shuey MM, Xiang RR, Moss ME, Carvajal BV, Wang Y, Camarda N, Fabbri D, Rahman P, Ramsey J, Stepanian A, Sebastiani P, Wells QS, Beckman JA, Jaffe IZ. Systems Approach to Integrating Preclinical Apolipoprotein E-Knockout Investigations Reveals Novel Etiologic Pathways and Master Atherosclerosis Network in Humans. Arterioscler Thromb Vasc Biol. 2022 01; 42(1):35-48. PMID: 34758633; PMCID: PMC8887835; DOI: 10.1161/ATVBAHA.121.317071;

Gurinovich A, Song Z, Zhang W, Federico A, Monti S, Andersen SL, Jennings LL, Glass DJ, Barzilai N, Millman S, Perls TT, Sebastiani P. Correction to: Effect of longevity genetic variants on the molecular aging rate. Geroscience. 2021 Aug; 43(4):2101.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 34143375; PMCID: PMC8492867; DOI: 10.1007/s11357-021-00400-7;

Gurinovich A, Song Z, Zhang W, Federico A, Monti S, Andersen SL, Jennings LL, Glass DJ, Barzilai N, Millman S, Perls TT, Sebastiani P. Effect of longevity genetic variants on the molecular aging rate. Geroscience. 2021 06; 43(3):1237-1251.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 33948810; PMCID: PMC8190315; DOI: 10.1007/s11357-021-00376-4;

Andersen SL, Du M, Cosentino S, Schupf N, Rosso AL, Perls TT, Sebastiani P. Slower Decline in Processing Speed Is Associated with Familial Longevity. Gerontology. 2022; 68(1):17-29.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 33946077; PMCID: PMC9093735; DOI: 10.1159/000514950;

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanché H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze JF, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylhä M, Kähönen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimäki T, Lieb W, Lyytikäinen LP, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine JM, Rotter JI, Sebastiani P, Smith J, Sørensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM. Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2021 Apr 23; 12(1):2463.View Related Profiles.

Murabito, Joanne
Lunetta, Kathryn
Sebastiani, Paola
Perls, Thomas

PMID: 33893282; PMCID: PMC8065049; DOI: 10.1038/s41467-021-22613-2;

Song Z, Gurinovich A, Federico A, Monti S, Sebastiani P. nf-gwas-pipeline: A Nextflow Genome-Wide Association Study Pipeline. J Open Source Softw. 2021; 6(59).View Related Profiles.

Sebastiani, Paola
Monti, Stefano

PMID: 35647481; PMCID: PMC9137404; DOI: 10.21105/joss.02957;

Sebastiani P, Federico A, Morris M, Gurinovich A, Tanaka T, Chandler KB, Andersen SL, Denis G, Costello CE, Ferrucci L, Jennings L, Glass DJ, Monti S, Perls TT. Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans. Aging Cell. 2021 02; 20(2):e13290.View Related Profiles.

Costello, Catherine
Denis, Gerald
Sebastiani, Paola
Andersen, Stacy
Monti, Stefano
Perls, Thomas

PMID: 33512769; PMCID: PMC7884029; DOI: 10.1111/acel.13290;

Xiang Q, Andersen SL, Perls TT, Sebastiani P. Studying the Interplay Between Apolipoprotein E and Education on Cognitive Decline in Centenarians Using Bayesian Beta Regression. Front Genet. 2020; 11:606831.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 33488674; PMCID: PMC7820893; DOI: 10.3389/fgene.2020.606831;

Andersen SL, Sweigart B, Glynn NW, Wojczynski MK, Thyagarajan B, Mengel-From J, Thielke S, Perls TT, Libon DJ, Au R, Cosentino S, Sebastiani P. Digital Technology Differentiates Graphomotor and Information Processing Speed Patterns of Behavior. J Alzheimers Dis. 2021; 82(1):17-32.View Related Profiles.

Sebastiani, Paola
Au, Rhoda
Andersen, Stacy
Perls, Thomas

PMID: 34219735; PMCID: PMC8328075; DOI: 10.3233/JAD-201119;

Sweigart B, Andersen SL, Gurinovich A, Cosentino S, Schupf N, Perls TT, Sebastiani P. APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age. J Alzheimers Dis. 2021; 83(2):853-860.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 34366332; PMCID: PMC8896199; DOI: 10.3233/JAD-201205;

Du M, Andersen SL, Schupf N, Feitosa MF, Barker MS, Perls TT, Sebastiani P. Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study. J Alzheimers Dis. 2021; 79(1):117-125.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 33216038; PMCID: PMC7952213; DOI: 10.3233/JAD-201113;

Ma Y, Jenkins HE, Sebastiani P, Ellner JJ, Jones-López EC, Dietze R, Horsburgh CR, White LF. Using Cure Models to Estimate the Serial Interval of Tuberculosis With Limited Follow-up. Am J Epidemiol. 2020 11 02; 189(11):1421-1426.View Related Profiles.

Horsburgh, C.
Jenkins, Helen
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Sebastiani, Paola

PMID: 32458995; PMCID: PMC7731991; DOI: 10.1093/aje/kwaa090;

Sebastiani P, Andersen SL, Sweigart B, Du M, Cosentino S, Thyagarajan B, Christensen K, Schupf N, Perls TT. Patterns of multi-domain cognitive aging in participants of the Long Life Family Study. Geroscience. 2020 10; 42(5):1335-1350.View Related Profiles.

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Andersen, Stacy
Perls, Thomas

PMID: 32514870; PMCID: PMC7525612; DOI: 10.1007/s11357-020-00202-3;

Leavitt SV, Lee RS, Sebastiani P, Horsburgh CR, Jenkins HE, White LF. Estimating the relative probability of direct transmission between infectious disease patients. Int J Epidemiol. 2020 06 01; 49(3):764-775.View Related Profiles.

Horsburgh, C.
Jenkins, Helen
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PMID: 32211747; PMCID: PMC7394954; DOI: 10.1093/ije/dyaa031;

Westerman K, Fernández-Sanlés A, Patil P, Sebastiani P, Jacques P, Starr JM, J Deary I, Liu Q, Liu S, Elosua R, DeMeo DL, Ordovás JM. Epigenomic Assessment of Cardiovascular Disease Risk and Interactions With Traditional Risk Metrics. J Am Heart Assoc. 2020 04 21; 9(8):e015299. PMID: 32308120; PMCID: PMC7428544; DOI: 10.1161/JAHA.119.015299;

Santanasto AJ, Marron MM, Boudreau RM, Feitosa MF, Wojczynski MK, Arbeev KG, Thyagarajan B, Schupf N, Stallard E, Sebastiani P, Cosentino S, Christensen K, Newman AB. Prevalence, Incidence, and Risk Factors for Overall, Physical, and Cognitive Independence Among Those From Exceptionally Long-Lived Families: The Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2020 04 17; 75(5):899-905. PMID: 31086986; PMCID: PMC7164521; DOI: 10.1093/gerona/glz124;

Westerman K, Liu Q, Liu S, Parnell LD, Sebastiani P, Jacques P, DeMeo DL, Ordovás JM. A gene-diet interaction-based score predicts response to dietary fat in the Women's Health Initiative. Am J Clin Nutr. 2020 04 01; 111(4):893-902. PMID: 32135010; PMCID: PMC7138684; DOI: 10.1093/ajcn/nqaa037;

Marone S, Bloore K, Sebastiani P, Flynn C, Leonard B, Whitaker K, Mostowy M, Perls TT, Andersen SL. Purpose in Life Among Centenarian Offspring. J Gerontol B Psychol Sci Soc Sci. 2020 01 14; 75(2):308-315.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 29522128; PMCID: PMC7179803; DOI: 10.1093/geronb/gby023;

Li A, Chapuy B, Varelas X, Sebastiani P, Monti S. Identification of candidate cancer drivers by integrative Epi-DNA and Gene Expression (iEDGE) data analysis. Sci Rep. 2019 11 15; 9(1):16904.View Related Profiles.

Sebastiani, Paola
Monti, Stefano
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PMID: 31729402; PMCID: PMC6858347; DOI: 10.1038/s41598-019-52886-z;

Gurinovich A, Andersen SL, Puca A, Atzmon G, Barzilai N, Sebastiani P. Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities. J Gerontol A Biol Sci Med Sci. 2019 11 13; 74(Suppl_1):S45-S51.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy

PMID: 31724059; PMCID: PMC7330482; DOI: 10.1093/gerona/glz179;

Dai Y, Shaikho EM, Perez J, Wilson CA, Liu LY, White MR, Farrell JJ, Chui DHK, Sebastiani P, Steinberg MH. BCL2L1 is associated with ?-globin gene expression. Blood Adv. 2019 10 22; 3(20):2995-3001.View Related Profiles.

Chui, David
Steinberg, Martin
Sebastiani, Paola
Dai, Yan

PMID: 31648320; PMCID: PMC6849934; DOI: 10.1182/bloodadvances.2019032243;

Westerman K, Sebastiani P, Jacques P, Liu S, DeMeo D, Ordovás JM. DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure. Clin Epigenetics. 2019 10 15; 11(1):142. PMID: 31615550; PMCID: PMC6792327; DOI: 10.1186/s13148-019-0705-2;

Bae H, Lunetta KL, Murabito JM, Andersen SL, Schupf N, Perls T, Sebastiani P. Genetic associations with age of menopause in familial longevity. Menopause. 2019 10; 26(10):1204-1212.View Related Profiles.

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Andersen, Stacy
Perls, Thomas

PMID: 31188284; PMCID: PMC7008937; DOI: 10.1097/GME.0000000000001367;

Montano M, Bhasin S, D'Aquila RT, Erlandson KM, Evans WJ, Funderburg NT, Justice A, Ndhlovu LC, Ojikutu B, Pahor M, Pahwa S, Ryan AS, Schrack J, Schultz MB, Sebastiani P, Sinclair DA, Tripp J, Walker B, Womack JA, Yung R, Reeves RK. Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research. AIDS Res Hum Retroviruses. 2019 Nov/Dec; 35(11-12):999-1012. PMID: 31456412; PMCID: PMC6862961; DOI: 10.1089/aid.2019.0130;

Gurinovich A, Bae H, Farrell JJ, Andersen SL, Monti S, Puca A, Atzmon G, Barzilai N, Perls TT, Sebastiani P. PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects. Bioinformatics. 2019 09 01; 35(17):3046-3054.View Related Profiles.

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Andersen, Stacy
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Perls, Thomas

PMID: 30624692; PMCID: PMC6735784; DOI: 10.1093/bioinformatics/btz017;

Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, Ware EB, Sarnowski C, Smith AV, Seppälä I, Cordell HJ, Dose J, Amin N, Arnold AM, Ayers KL, Barzilai N, Becker EJ, Beekman M, Blanché H, Christensen K, Christiansen L, Collerton JC, Cubaynes S, Cummings SR, Davies K, Debrabant B, Deleuze JF, Duncan R, Faul JD, Franceschi C, Galan P, Gudnason V, Harris TB, Huisman M, Hurme MA, Jagger C, Jansen I, Jylhä M, Kähönen M, Karasik D, Kardia SLR, Kingston A, Kirkwood TBL, Launer LJ, Lehtimäki T, Lieb W, Lyytikäinen LP, Martin-Ruiz C, Min J, Nebel A, Newman AB, Nie C, Nohr EA, Orwoll ES, Perls TT, Province MA, Psaty BM, Raitakari OT, Reinders MJT, Robine JM, Rotter JI, Sebastiani P, Smith J, Sørensen TIA, Taylor KD, Uitterlinden AG, van der Flier W, van der Lee SJ, van Duijn CM, van Heemst D, Vaupel JW, Weir D, Ye K, Zeng Y, Zheng W, Holstege H, Kiel DP, Lunetta KL, Slagboom PE, Murabito JM. A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun. 2019 08 14; 10(1):3669.View Related Profiles.

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Perls, Thomas

PMID: 31413261; PMCID: PMC6694136; DOI: 10.1038/s41467-019-11558-2;

Sebastiani P, Monti S, Morris M, Gurinovich A, Toshiko T, Andersen SL, Sweigart B, Ferrucci L, Jennings LL, Glass DJ, Perls TT. A serum protein signature of APOE genotypes in centenarians. Aging Cell. 2019 12; 18(6):e13023.View Related Profiles.

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Andersen, Stacy
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Perls, Thomas

PMID: 31385390; PMCID: PMC6826130; DOI: 10.1111/acel.13023;

Marron MM, Wojczynski MK, Minster RL, Boudreau RM, Sebastiani P, Cosentino S, Thyagarajan B, Ukraintseva SV, Schupf N, Christensen K, Feitosa M, Perls T, Zmuda JM, Newman AB. Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism. Geroscience. 2019 08; 41(4):383-393.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 31332674; PMCID: PMC6815318; DOI: 10.1007/s11357-019-00086-y;

Kartha VK, Sebastiani P, Kern JG, Zhang L, Varelas X, Monti S. CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features. Front Genet. 2019; 10:121.View Related Profiles.

Kern, Joseph
Sebastiani, Paola
Monti, Stefano
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PMID: 30838036; PMCID: PMC6390206; DOI: 10.3389/fgene.2019.00121;

Marron MM, Miljkovic I, Boudreau RM, Christensen K, Feitosa MF, Lee JH, Sebastiani P, Thyagarajan B, Wojczynski MK, Zmuda JM, Newman AB. A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity. Metabolism. 2019 05; 94:28-38. PMID: 30710575; PMCID: PMC7099575; DOI: 10.1016/j.metabol.2019.01.010;

Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT. APOE Alleles and Extreme Human Longevity. J Gerontol A Biol Sci Med Sci. 2019 01 01; 74(1):44-51.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 30060062; PMCID: PMC6298189; DOI: 10.1093/gerona/gly174;

Andersen SL, Sweigart B, Sebastiani P, Drury J, Sidlowski S, Perls TT. Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring. J Gerontol A Biol Sci Med Sci. 2019 01 01; 74(1):108-113.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 29931286; PMCID: PMC6298187; DOI: 10.1093/gerona/gly141;

Bae H, Gurinovich A, Malovini A, Atzmon G, Andersen SL, Villa F, Barzilai N, Puca A, Perls TT, Sebastiani P. Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies. J Gerontol A Biol Sci Med Sci. 2018 10 08; 73(11):1439-1447.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 28977569; PMCID: PMC6175020; DOI: 10.1093/gerona/glx124;

Nebbia G, Nussbaum L, Helmkamp A, Andersen S, Perls T, Sebastiani P. Manual and Automated Procedures for Compiling a Very Large Sample of Centenarian Pedigrees. N Am Actuar J. 2018; 22(4):591-599.View Related Profiles.

Helmkamp, Annie
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 31435182; PMCID: PMC6703835; DOI: 10.1080/10920277.2018.1462716;

Nebbia G, Nussbaum L, Helmkamp A, Andersen SL, Perls TT, Sebastiani P. Manual and Automated Procedures for Compiling a Very Large Sample of Centenarian Pedigrees. North American Actuarial Journal. 2018; 1-9.

Zeng Y, Nie C, Min J, Chen H, Liu X, Ye R, Chen Z, Bai C, Xie E, Yin Z, Lv Y, Lu J, Li J, Ni T, Bolund L, Land KC, Yashin A, O'Rand AM, Sun L, Yang Z, Tao W, Gurinovich A, Franceschi C, Xie J, Gu J, Hou Y, Liu X, Xu X, Robine JM, Deelen J, Sebastiani P, Slagboom E, Perls T, Hauser E, Gottschalk W, Tan Q, Christensen K, Shi X, Lutz M, Tian XL, Yang H, Vaupel J. Sex Differences in Genetic Associations With Longevity. JAMA Netw Open. 2018 Aug; 1(4).View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 30294719; PMCID: PMC6173523; DOI: 10.1001/jamanetworkopen.2018.1670;

Du M, Van Ness S, Gordeuk V, Nouraie SM, Nekhai S, Gladwin M, Steinberg MH, Sebastiani P. Biomarker signatures of sickle cell disease severity. Blood Cells Mol Dis. 2018 09; 72:1-9.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola

PMID: 29778312; PMCID: PMC6087499; DOI: 10.1016/j.bcmd.2018.05.001;

Denis GV, Sebastiani P, Bertrand KA, Strissel KJ, Tran AH, Slama J, Medina ND, Andrieu G, Palmer JR. Inflammatory signatures distinguish metabolic health in African American women with obesity. PLoS One. 2018; 13(5):e0196755.View Related Profiles.

Denis, Gerald
Slama, Jaromir
Palmer, Julie
Bertrand, Kimberly
Medina, Nilton
Sebastiani, Paola

PMID: 29738558; PMCID: PMC5940209; DOI: 10.1371/journal.pone.0196755;

Marron MM, Singh J, Boudreau RM, Christensen K, Cosentino S, Feitosa MF, Minster RL, Perls T, Schupf N, Sebastiani P, Ukraintseva S, Wojczynski MK, Newman AB. A novel healthy blood pressure phenotype in the Long Life Family Study. J Hypertens. 2018 01; 36(1):43-53.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 28837423; PMCID: PMC5893936; DOI: 10.1097/HJH.0000000000001514;

Du M, Van Ness S, Gordeuk VR, Gladwin MT, Sebastiani S, Steinberg MH. Blood. Biomarker Signatures of Sickle Cell Disease Severity. American Society of Hematology. 2017; 130(Suppl. 1):690-690.

Sebastiani P, Gurinovich A, Bae H, Andersen SL, Perls TT. Assortative Mating by Ethnicity in Longevous Families. Front Genet. 2017; 8:186.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 29209360; PMCID: PMC5702482; DOI: 10.3389/fgene.2017.00186;

Sebastiani P, Palmer L. Wiley StatsRef-Statistics Reference Online. Human Genome Project. Wiley. New York. 2017; Online 1-6. View Publication

Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben-Avraham D, Barzilai N, Puca A, Perls TT. Four Genome-Wide Association Studies Identify New Extreme Longevity Variants. J Gerontol A Biol Sci Med Sci. 2017 Oct 12; 72(11):1453-1464.View Related Profiles.

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Andersen, Stacy
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PMID: 28329165; PMCID: PMC5861867; DOI: 10.1093/gerona/glx027;

Denis GV, Sebastiani P, Andrieu G, Tran AH, Strissel KJ, Lombardi FL, Palmer JR. Relationships Among Obesity, Type 2 Diabetes, and Plasma Cytokines in African American Women. Obesity (Silver Spring). 2017 Nov; 25(11):1916-1920.View Related Profiles.

Denis, Gerald
Palmer, Julie
Sebastiani, Paola

PMID: 28840653; PMCID: PMC5669048; DOI: 10.1002/oby.21943;

Shaikho EM, Farrell JJ, Alsultan A, Qutub H, Al-Ali AK, Figueiredo MS, Chui DHK, Farrer LA, Murphy GJ, Mostoslavsky G, Sebastiani P, Steinberg MH. A phased SNP-based classification of sickle cell anemia HBB haplotypes. BMC Genomics. 2017 Aug 11; 18(1):608.View Related Profiles.

Chui, David
Murphy, George
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Sebastiani, Paola

PMID: 28800727; PMCID: PMC5553663; DOI: 10.1186/s12864-017-4013-y;

Shaikho EM, Farrell JJ, Alsultan A, Sebastiani P, Steinberg MH. Genetic determinants of HbF in Saudi Arabian and African Benin haplotype sickle cell anemia. Am J Hematol. 2017 09; 92(9):E555-E557.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola

PMID: 28612458; PMCID: PMC5546992; DOI: 10.1002/ajh.24822;

Fagan E, Sun F, Bae H, Elo I, Andersen SL, Lee J, Christensen K, Thyagarajan B, Sebastiani P, Perls T, Honig LS, Schupf N. Telomere length is longer in women with late maternal age. Menopause. 2017 May; 24(5):497-501.View Related Profiles.

Sun, Fangui
Sebastiani, Paola
Andersen, Stacy
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PMID: 27922939; PMCID: PMC5403597; DOI: 10.1097/GME.0000000000000795;

Guha A, Deshpande A, Jain A, Sebastiani P, Cardoso WV. Uroplakin 3a+ Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair. Cell Rep. 2017 Apr 11; 19(2):246-254.View Related Profiles.

Guha, Arjun
Sebastiani, Paola
Cardoso, Wellington

PMID: 28402849; DOI: 10.1016/j.celrep.2017.03.051;

Sebastiani P, Bae H, Gurinovich A, Soerensen M, Puca A, Perls TT. Limitations and risks of meta-analyses of longevity studies. Mech Ageing Dev. 2017 Jul; 165(Pt B):139-146.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 28143747; PMCID: PMC5533653; DOI: 10.1016/j.mad.2017.01.008;

Park S, Gianotti-Sommer A, Molina-Estevez FJ, Vanuytsel K, Skvir N, Leung A, Rozelle SS, Shaikho EM, Weir I, Jiang Z, Luo HY, Chui DHK, Figueiredo MS, Alsultan A, Al-Ali A, Sebastiani P, Steinberg MH, Mostoslavsky G, Murphy GJ. A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Apr 11; 8(4):1076-1085.View Related Profiles.

Chui, David
Murphy, George
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Luo, Hong
Vanuytsel, Kim
Steinberg, Martin
Sebastiani, Paola
Jiang, Zhihua

PMID: 28111279; PMCID: PMC5390092; DOI: 10.1016/j.stemcr.2016.12.017;

Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman AB, Montano M, Perls TT. Biomarker signatures of aging. Aging Cell. 2017 Apr; 16(2):329-338.View Related Profiles.

Sun, Fangui
Sebastiani, Paola
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PMID: 28058805; PMCID: PMC5334528; DOI: 10.1111/acel.12557;

Brogly SB, Saia K, Hernández-Diaz S, Werler M, Sebastiani P. The comparative safety of buprenorphine versus methadone in pregnancy-what about confounding? Addiction. 2016 12; 111(12):2130-2131.View Related Profiles.

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PMID: 28075537; PMCID: PMC5571444; DOI: 10.1111/add.13551;

Sebastiani P, Thyagarajan B, Sun F, Honig LS, Schupf N, Cosentino S, Feitosa MF, Wojczynski M, Newman AB, Montano M, Perls TT. Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study. J Am Geriatr Soc. 2016 Nov; 64(11):e189-e194.View Related Profiles.

Sun, Fangui
Sebastiani, Paola
Perls, Thomas

PMID: 27783390; PMCID: PMC5118076; DOI: 10.1111/jgs.14522;

Vathipadiekal V, Farrell JJ, Wang S, Edward HL, Shappell H, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Simkin I, Farrer LA, Jiang Z, Luo HY, Huang S, Mostoslavsky G, Murphy GJ, Patra PK, Chui DH, Alsultan A, Al-Ali AK, Sebastiani P, Steinberg MH. A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia. Am J Hematol. 2016 Nov; 91(11):1118-1122.View Related Profiles.

Chui, David
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Sebastiani, Paola
Vathipadiekal, Vinod
Jiang, Zhihua

PMID: 27501013; PMCID: PMC5072989; DOI: 10.1002/ajh.24527;

Sebastiani P, Perls TT. Detection of Significant Groups in Hierarchical Clustering by Resampling. Front Genet. 2016; 7:144.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 27551289; PMCID: PMC4976109; DOI: 10.3389/fgene.2016.00144;

Ismail K, Nussbaum L, Sebastiani P, Andersen S, Perls T, Barzilai N, Milman S. Compression of Morbidity Is Observed Across Cohorts with Exceptional Longevity. J Am Geriatr Soc. 2016 Aug; 64(8):1583-91.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 27377170; PMCID: PMC4988893; DOI: 10.1111/jgs.14222;

Bae H, Monti S, Montano M, Steinberg MH, Perls TT, Sebastiani P. Learning Bayesian Networks from Correlated Data. Sci Rep. 2016 05 05; 6:25156.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola
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PMID: 27146517; PMCID: PMC4857179; DOI: 10.1038/srep25156;

Vathipadiekal V, Alsultan A, Baltrusaitis K, Farrell JJ, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Suliman A, Patra PK, Milton JN, Farrer LA, Chui DH, Al-Ali AK, Sebastiani P, Steinberg MH. Homozygosity for a haplotype in the HBG2-OR51B4 region is exclusive to Arab-Indian haplotype sickle cell anemia. Am J Hematol. 2016 06; 91(6):E308-11.View Related Profiles.

Chui, David
Hicks, Jacqueline
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Sebastiani, Paola
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PMID: 27185208; PMCID: PMC4874527; DOI: 10.1002/ajh.24368;

Shaikho EM, Habara AH, Alsultan A, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Patra PK, Sebastiani P, Baltrusaitis K, Farrell JJ, Jiang Z, Luo HY, Chui DH, Al-Ali AK, Steinberg MH. Variants of ZBTB7A (LRF) and its ß-globin gene cluster binding motifs in sickle cell anemia. Blood Cells Mol Dis. 2016 07; 59:49-51.View Related Profiles.

Chui, David
Luo, Hong
Steinberg, Martin
Sebastiani, Paola
Jiang, Zhihua

PMID: 27282567; PMCID: PMC6733020; DOI: 10.1016/j.bcmd.2016.04.001;

Liu L, Pertsemlidis A, Ding LH, Story MD, Steinberg MH, Sebastiani P, Hoppe C, Ballas SK, Pace BS. Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease. Exp Biol Med (Maywood). 2016 Apr; 241(7):706-18.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola

PMID: 27022141; PMCID: PMC4950389; DOI: 10.1177/1535370216642047;

Zeng Y, Nie C, Min J, Liu X, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL, Yang H, Vaupel JW. Novel loci and pathways significantly associated with longevity. Sci Rep. 2016 Feb 25; 6:21243.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 26912274; PMCID: PMC4766491; DOI: 10.1038/srep21243;

Sebastiani P, Andersen SL, McIntosh AI, Nussbaum L, Stevenson MD, Pierce L, Xia S, Salance K, Perls TT. Familial Risk for Exceptional Longevity. N Am Actuar J. 2016 Jan 01; 20(1):57-64.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 27041978; PMCID: PMC4812435; DOI: 10.1080/10920277.2015.1061946;

Zhang X, Zhang W, Saraf SL, Nouraie M, Han J, Gowhari M, Hassan J, Miasnikova G, Sergueeva A, Nekhai S, Kittles R, Machado RF, Garcia JG, Gladwin MT, Steinberg MH, Sebastiani P, McClain DA, Gordeuk VR. Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease. Hum Genet. 2015 Aug; 134(8):895-904.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola

PMID: 26025476; PMCID: PMC4607040; DOI: 10.1007/s00439-015-1572-3;

Wong K, Sun F, Trudel G, Sebastiani P, Laneuville O. Temporal gene expression profiling of the rat knee joint capsule during immobilization-induced joint contractures. BMC Musculoskelet Disord. 2015; 16:125.View Related Profiles.

Sun, Fangui
Sebastiani, Paola

PMID: 26006773; PMCID: PMC4443538; DOI: 10.1186/s12891-015-0588-0;

Sebastiani P, Nussbaum L, Andersen SL, Black MJ, Perls TT. Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of "Aging," "Life Span," and "Longevity". J Gerontol A Biol Sci Med Sci. 2016 Mar; 71(3):340-6.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 25814633; PMCID: PMC4757962; DOI: 10.1093/gerona/glv020;

Bae H, Perls T, Steinberg M, Sebastiani P. Bayesian Polynomial Regression Models to Fit Multiple Genetic Models for Quantitative Traits. Bayesian Anal. 2015 Mar; 10(1):53-74.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola
Perls, Thomas

PMID: 26029316; PMCID: PMC4446790; DOI: 10.1214/14-BA880;

Stevenson M, Bae H, Schupf N, Andersen S, Zhang Q, Perls T, Sebastiani P. Burden of disease variants in participants of the Long Life Family Study. Aging (Albany NY). 2015 Feb; 7(2):123-32.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 25664523; PMCID: PMC4359694; DOI: 10.18632/aging.100724;

Sebastiani P, Farrell JJ, Alsultan A, Wang S, Edward HL, Shappell H, Bae H, Milton JN, Baldwin CT, Al-Rubaish AM, Naserullah Z, Al-Muhanna F, Alsuliman A, Patra PK, Farrer LA, Ngo D, Vathipadiekal V, Chui DH, Al-Ali AK, Steinberg MH. BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia. Blood Cells Mol Dis. 2015 Mar; 54(3):224-30.View Related Profiles.

Chui, David
Ngo, Doan
Ngo, Duyen
Hicks, Jacqueline
Farrer, Lindsay
Steinberg, Martin
Sebastiani, Paola
Vathipadiekal, Vinod

PMID: 25703683; PMCID: PMC4341902; DOI: 10.1016/j.bcmd.2015.01.001;

Milton JN, Steinberg MH, Sebastiani P. Evaluation of an ensemble of genetic models for prediction of a quantitative trait. Front Genet. 2014; 5:474.View Related Profiles.

Hicks, Jacqueline
Steinberg, Martin
Sebastiani, Paola

PMID: 25628649; PMCID: PMC4292739; DOI: 10.3389/fgene.2014.00474;

P Sebastiani. J Amer Statist. Assoc. Review of the book by M. Scutari and JB Denis, “Bayesian Networks with Examples in R”. 2015; 110:880-881.
Bae HT, Perls TT, Steinberg MH, Sebastiani P . Bayesian polynomial regression models to fit multiple genetic models for quantitative traits. Bayesian Analysis Journal. 2015; 1(10):53-74.
Sebastiani P, Nussbaum L, Andersen S, Black M, Perls TT. Increasing Sibling Relative Risk of Survival to Older and Older Ages and the Importance of Precise Definitions of Aging, Life span and Longevity. J. Gerontol A Biol Sci. 2015.

Sun F, Sebastiani P, Schupf N, Bae H, Andersen SL, McIntosh A, Abel H, Elo IT, Perls TT. Extended maternal age at birth of last child and women's longevity in the Long Life Family Study. Menopause. 2015 Jan; 22(1):26-31.View Related Profiles.

Sun, Fangui
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 24977462; PMCID: PMC4270889; DOI: 10.1097/GME.0000000000000276;

Sebastiani P, Andersen SL, McIntosh AI, Nussbaum L, Stevenson MD, Pierce L, Xia S, Salance K, Perls TT. Familial Risk for Exceptional Longevity. North Am. Actuar. J. 2015.

Bae HT, Perls TT, Sebastiani P. An efficient technique for Bayesian modeling of family data using the BUGS software. Front Genet. 2014; 5:390.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 25477899; PMCID: PMC4235415; DOI: 10.3389/fgene.2014.00390;

Broer L, Buchman AS, Deelen J, Evans DS, Faul JD, Lunetta KL, Sebastiani P, Smith JA, Smith AV, Tanaka T, Yu L, Arnold AM, Aspelund T, Benjamin EJ, De Jager PL, Eirkisdottir G, Evans DA, Garcia ME, Hofman A, Kaplan RC, Kardia SL, Kiel DP, Oostra BA, Orwoll ES, Parimi N, Psaty BM, Rivadeneira F, Rotter JI, Seshadri S, Singleton A, Tiemeier H, Uitterlinden AG, Zhao W, Bandinelli S, Bennett DA, Ferrucci L, Gudnason V, Harris TB, Karasik D, Launer LJ, Perls TT, Slagboom PE, Tranah GJ, Weir DR, Newman AB, van Duijn CM, Murabito JM. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J Gerontol A Biol Sci Med Sci. 2015 Jan; 70(1):110-8.View Related Profiles.

Benjamin, Emelia
Murabito, Joanne
Lunetta, Kathryn
Sebastiani, Paola
Seshadri, Sudha
Perls, Thomas

PMID: 25199915; PMCID: PMC4296168; DOI: 10.1093/gerona/glu166;

Brogly SB, Saia KA, Walley AY, Du HM, Sebastiani P. Prenatal buprenorphine versus methadone exposure and neonatal outcomes: systematic review and meta-analysis. Am J Epidemiol. 2014 Oct 1; 180(7):673-86.View Related Profiles.

Walley, Alexander
Saia, Kelley
Sebastiani, Paola
Brogly, Susan

PMID: 25150272; DOI: 10.1093/aje/kwu190;

Griffin PJ, Sebastiani P, Edward H, Baldwin CT, Gladwin MT, Gordeuk VR, Chui DH, Steinberg MH. The genetics of hemoglobin A2 regulation in sickle cell anemia. Am J Hematol. 2014 Nov; 89(11):1019-23.View Related Profiles.

Chui, David
Steinberg, Martin
Sebastiani, Paola

PMID: 25042611; PMCID: PMC4298130; DOI: 10.1002/ajh.23811;

Milton JN, Gordeuk VR, Taylor JG, Gladwin MT, Steinberg MH, Sebastiani P. Prediction of fetal hemoglobin in sickle cell anemia using an ensemble of genetic risk prediction models. Circ Cardiovasc Genet. 2014 Apr; 7(2):110-5.View Related Profiles.

Hicks, Jacqueline
Steinberg, Martin
Sebastiani, Paola

PMID: 24585758; PMCID: PMC3994553; DOI: 10.1161/CIRCGENETICS.113.000387;

Zhang X, Zhang W, Ma SF, Desai AA, Saraf S, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Abbasi T, Casanova NG, Steinberg MH, Baldwin CT, Sebastiani P, Prchal JT, Kittles R, Garcia JG, Machado RF, Gordeuk VR. Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. Circulation. 2014 Apr 22; 129(16):1650-8.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola

PMID: 24515990; PMCID: PMC4287376; DOI: 10.1161/CIRCULATIONAHA.113.005296;

Sebastiani P, Andersen SL, McIntosh AI, Nussbaum L, Stevenson MD, Pierce L, Xia S, Salance K, Perls TT. Contribution of Familial Longevity to Living to 100. 2014 Living to 100 Monograph. 2014.

Alsultan A, Alabdulaali MK, Griffin PJ, Alsuliman AM, Ghabbour HA, Sebastiani P, Albuali WH, Al-Ali AK, Chui DH, Steinberg MH. Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab-Indian haplotype is not benign. Br J Haematol. 2014 Feb; 164(4):597-604.View Related Profiles.

Chui, David
Steinberg, Martin
Sebastiani, Paola

PMID: 24224700; PMCID: PMC4094128; DOI: 10.1111/bjh.12650;

Steinberg MH, Chui DH, Dover GJ, Sebastiani P, Alsultan A. Fetal hemoglobin in sickle cell anemia: a glass half full? Blood. 2014 Jan 23; 123(4):481-5.View Related Profiles.

Chui, David
Steinberg, Martin
Sebastiani, Paola

PMID: 24222332; DOI: 10.1182/blood-2013-09-528067;

Baranoski AS, Harris A, Michaels D, Miciek R, Storer T, Sebastiani P, Montano M. Relationship between poor physical function, inflammatory markers, and comorbidities in HIV-infected women on antiretroviral therapy. J Womens Health (Larchmt). 2014 Jan; 23(1):69-76.View Related Profiles.

Montano, Monty
Sebastiani, Paola

PMID: 24219874; PMCID: PMC3880911; DOI: 10.1089/jwh.2013.4367;

Sebastiani P, Sun FX, Andersen SL, Lee JH, Wojczynski MK, Sanders JL, Yashin A, Newman AB, Perls TT. Families Enriched for Exceptional Longevity also have Increased Health-Span: Findings from the Long Life Family Study. Front Public Health. 2013; 1:38.View Related Profiles.

Sun, Fangui
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 24350207; PMCID: PMC3859985; DOI: 10.3389/fpubh.2013.00038;

Sebastiani P, Bae H, Sun FX, Andersen SL, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A, Perls TT. Meta-analysis of genetic variants associated with human exceptional longevity. Aging (Albany NY). 2013 Sep; 5(9):653-61.View Related Profiles.

Sun, Fangui
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 24244950; PMCID: PMC3808698; DOI: 10.18632/aging.100594;

Elo IT, Mykyta L, Sebastiani P, Christensen K, Glynn NW, Perls T. Age validation in the long life family study through a linkage to early-life census records. J Gerontol B Psychol Sci Soc Sci. 2013 Jul; 68(4):580-5.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 23704206; PMCID: PMC3674734; DOI: 10.1093/geronb/gbt033;

Bae HT, Sebastiani P, Sun JX, Andersen SL, Daw EW, Terracciano A, Ferrucci L, Perls TT. Genome-wide association study of personality traits in the long life family study. Front Genet. 2013; 4:65.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 23658558; PMCID: PMC3647245; DOI: 10.3389/fgene.2013.00065;

Alsultan A, Ngo D, Bae H, Sebastiani P, Baldwin CT, Melista E, Suliman AM, Albuali WH, Nasserullah Z, Luo HY, Chui DH, Steinberg MH, Al-Ali AK. Genetic studies of fetal hemoglobin in the Arab-Indian haplotype sickle cell-ß(0) thalassemia. Am J Hematol. 2013 Jun; 88(6):531-2.View Related Profiles.

Baldwin, Clinton
Chui, David
Ngo, Duyen
Steinberg, Martin
Sebastiani, Paola

PMID: 23483609; DOI: 10.1002/ajh.23434;

Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med. 2013 May 1; 187(9):933-42.View Related Profiles.

Spira, Avrum
Dumont, Charles
Liu, Gang
O'Connor, George
Duclos, Grant
Campbell, Joshua
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Alekseyev, Yuriy

PMID: 23471465; PMCID: PMC3707363; DOI: 10.1164/rccm.201208-1449OC;

Friedman R, Kudesia V, Sebastiani P, Monti S, Misquitta D, Peterson K, Whinfield J, Stoeckle R. Educating translational researchers in research informatics principles and methods: an evaluation of a model online course and plans for its dissemination. AMIA Summits Transl Sci Proc. 2013; 2013:59.View Related Profiles.

Sebastiani, Paola
Friedman, Robert
Monti, Stefano
Kudesia, Valmeek

PMID: 24303298; PMCID: PMC3814464

Ngo D, Bae H, Steinberg MH, Sebastiani P, Solovieff N, Baldwin CT, Melista E, Safaya S, Farrer LA, Al-Suliman AM, Albuali WH, Al Bagshi MH, Naserullah Z, Akinsheye I, Gallagher P, Luo HY, Chui DH, Farrell JJ, Al-Ali AK, Alsultan A. Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype. Blood Cells Mol Dis. 2013 Jun; 51(1):22-6.View Related Profiles.

Baldwin, Clinton
Chui, David
Ngo, Duyen
Luo, Hong
Farrer, Lindsay
Steinberg, Martin
Sebastiani, Paola

PMID: 23465615; PMCID: PMC3647015; DOI: 10.1016/j.bcmd.2012.12.005;

Hartley SW, Sebastiani P. PleioGRiP: genetic risk prediction with pleiotropy. Bioinformatics. 2013 Apr 15; 29(8):1086-8. PMID: 23419378; PMCID: PMC3624803; DOI: 10.1093/bioinformatics/btt081;

Milton JN, Rooks H, Drasar E, McCabe EL, Baldwin CT, Melista E, Gordeuk VR, Nouraie M, Kato GR, Minniti C, Taylor J, Campbell A, Luchtman-Jones L, Rana S, Castro O, Zhang Y, Thein SL, Sebastiani P, Gladwin MT, Steinberg MH. Genetic determinants of haemolysis in sickle cell anaemia. Br J Haematol. 2013 Apr; 161(2):270-8.View Related Profiles.

Baldwin, Clinton
Hicks, Jacqueline
Steinberg, Martin
Sebastiani, Paola

PMID: 23406172; PMCID: PMC4129543; DOI: 10.1111/bjh.12245;

Sebastiani P, Bae H, McIntosh A, Monti S. Bayesian Graphical Models for Gene-Environment Interaction. Proceedings of the JSM, 2013. 2013.

Andersen SL, Sun JX, Sebastiani P, Huntly J, Gass JD, Feldman L, Bae H, Christiansen L, Perls TT. Personality factors in the Long Life Family Study. J Gerontol B Psychol Sci Soc Sci. 2013 Sep; 68(5):739-49.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 23275497; PMCID: PMC3744045; DOI: 10.1093/geronb/gbs117;

Sebastiani P, Perls TT. The genetics of extreme longevity: lessons from the new England centenarian study. Front Genet. 2012; 3:277.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 23226160; PMCID: PMC3510428; DOI: 10.3389/fgene.2012.00277;

Sturiale CL, Puca A, Sebastiani P, Gatto I, Albanese A, Di Rocco C, Maira G, Pola R. Single nucleotide polymorphisms associated with sporadic brain arteriovenous malformations: where do we stand? Brain. 2013 Feb; 136(Pt 2):665-81. PMID: 22975391; DOI: 10.1093/brain/aws180;

Hartley SW, Monti S, Liu CT, Steinberg MH, Sebastiani P. Bayesian methods for multivariate modeling of pleiotropic SNP associations and genetic risk prediction. Front Genet. 2012; 3:176.View Related Profiles.

Liu, Ching-Ti
Steinberg, Martin
Sebastiani, Paola
Monti, Stefano

PMID: 22973300; PMCID: PMC3438684; DOI: 10.3389/fgene.2012.00176;

Bae HT, Baldwin CT, Sebastiani P, Telen MJ, Ashley-Koch A, Garrett M, Hooper WC, Bean CJ, Debaun MR, Arking DE, Bhatnagar P, Casella JF, Keefer JR, Barron-Casella E, Gordeuk V, Kato GJ, Minniti C, Taylor J, Campbell A, Luchtman-Jones L, Hoppe C, Gladwin MT, Zhang Y, Steinberg MH. Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans. Blood. 2012 Aug 30; 120(9):1961-2.View Related Profiles.

Baldwin, Clinton
Steinberg, Martin
Sebastiani, Paola

PMID: 22936743; PMCID: PMC3433099; DOI: 10.1182/blood-2012-06-432849;

Banerjee C, Archin N, Michaels D, Belkina AC, Denis GV, Bradner J, Sebastiani P, Margolis DM, Montano M. BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol. 2012 Dec; 92(6):1147-54.View Related Profiles.

Belkina, Anna
Banerjee, Camellia
Denis, Gerald
Montano, Monty
Sebastiani, Paola

PMID: 22802445; PMCID: PMC3501896; DOI: 10.1189/jlb.0312165;

Kusko RL, Banerjee C, Long KK, Darcy A, Otis J, Sebastiani P, Melov S, Tarnopolsky M, Bhasin S, Montano M. Premature expression of a muscle fibrosis axis in chronic HIV infection. Skelet Muscle. 2012; 2(1):10.View Related Profiles.

Banerjee, Camellia
Montano, Monty
Sebastiani, Paola
Kusko, Rebecca
Bhasin, Shalender

PMID: 22676806; PMCID: PMC3407733; DOI: 10.1186/2044-5040-2-10;

Steinberg MH, Sebastiani P. Genetic modifiers of sickle cell disease. Am J Hematol. 2012 Aug; 87(8):795-803.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola

PMID: 22641398; PMCID: PMC4562292; DOI: 10.1002/ajh.23232;

Milton JN, Sebastiani P, Solovieff N, Hartley SW, Bhatnagar P, Arking DE, Dworkis DA, Casella JF, Barron-Casella E, Bean CJ, Hooper WC, DeBaun MR, Garrett ME, Soldano K, Telen MJ, Ashley-Koch A, Gladwin MT, Baldwin CT, Steinberg MH, Klings ES. A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. PLoS One. 2012; 7(4):e34741.View Related Profiles.

Baldwin, Clinton
Klings, Elizabeth
Hicks, Jacqueline
Steinberg, Martin
Sebastiani, Paola

PMID: 22558097; PMCID: PMC3338756; DOI: 10.1371/journal.pone.0034741;

Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS. Human longevity and common variations in the LMNA gene: a meta-analysis. Aging Cell. 2012 Jun; 11(3):475-81.View Related Profiles.

Baldwin, Clinton
Sebastiani, Paola
Perls, Thomas

PMID: 22340368; PMCID: PMC3350595; DOI: 10.1111/j.1474-9726.2012.00808.x;

Sebastiani P, Solovieff N, Sun JX. Naïve Bayesian Classifier and Genetic Risk Score for Genetic Risk Prediction of a Categorical Trait: Not so Different after all! Front Genet. 2012; 3:26. PMID: 22393331; PMCID: PMC3289795; DOI: 10.3389/fgene.2012.00026;

Sebastiani P, Solovieff N, Dewan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. Genetic signatures of exceptional longevity in humans. PLoS One. 2012; 7(1):e29848.View Related Profiles.

Baldwin, Clinton
Steinberg, Martin
Montano, Monty
Sebastiani, Paola
Myers, Richard
Andersen, Stacy
Perls, Thomas

PMID: 22279548; PMCID: PMC3261167; DOI: 10.1371/journal.pone.0029848;

Sebastiani P, Solovieff N, DeWan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. Genetic signatures of exceptional longevity in humans. PLoS ONE. 2012; 7. View Publication

Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls TT. Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. J Gerontol A Biol Sci Med Sci. 2012 Apr; 67(4):395-405.View Related Profiles.

Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 22219514; PMCID: PMC3309876; DOI: 10.1093/gerona/glr223;

Sebastiani P, Riva A, Montano M, Pham P, Torkamani A, Scherba E, Benson G, Milton JN, Baldwin CT, Andersen S, Schork NJ, Steinberg MH, Perls TT. Whole genome sequences of a male and female supercentenarian, ages greater than 114?years. Front Genet. 2011; 2:90.View Related Profiles.

Baldwin, Clinton
Hicks, Jacqueline
Steinberg, Martin
Montano, Monty
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 22303384; PMCID: PMC3262222; DOI: 10.3389/fgene.2011.00090;

Sebastiani P, Riva A, Montano M, Pham P, Torkamani T, Scherba E, Benson G, Milton JN, Baldwin CT, Andersen S, Schork NJ, Steinberg MJ, Perls TT. Whole genome sequences of a male and female supercentenarian, ages greater than 114 years. 2012. View Publication
N. Medina Medina, A. Broka, S. Lacey, H. Lin, E. Klings, C. T. Baldwin, M. H. Steinberg, P. Sebastiani. Lecture Notes in Computer Science: 6th International Conference on Practical Applications of Computational Biology and Bioinformatics. Comparing Bowtie and BWA to Align Short Reads from a RNA-Seq Experiment. 2012; 197-207.
P. Sebastiani. Lecture Notes in Computer Science: Advances in Intelligent Data Analysis XI. Intelligent data analysis of genetic data. 2012; 2-6.

Akinsheye I, Solovieff N, Ngo D, Malek A, Sebastiani P, Steinberg MH, Chui DH. Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans. Am J Hematol. 2012 Feb; 87(2):217-9.View Related Profiles.

Malek, Anita
Chui, David
Ngo, Duyen
Steinberg, Martin
Sebastiani, Paola

PMID: 22139998; PMCID: PMC3302931; DOI: 10.1002/ajh.22221;

Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Retraction. Science. 2011 Jul 22; 333(6041):404.View Related Profiles.

Baldwin, Clinton
Steinberg, Martin
Sebastiani, Paola
Myers, Richard
Andersen, Stacy
Perls, Thomas

PMID: 21778381; DOI: 10.1126/science.333.6041.404-a;

Banerjee C, Ulloor J, Dillon EL, Dahodwala Q, Franklin B, Storer T, Sebastiani P, Sheffield-Moore M, Urban RJ, Bhasin S, Montano M. Identification of serum biomarkers for aging and anabolic response. Immun Ageing. 2011; 8(1):5.View Related Profiles.

Banerjee, Camellia
Ulloor, Jagadish
Montano, Monty
Sebastiani, Paola
Bhasin, Shalender

PMID: 21689392; PMCID: PMC3135554; DOI: 10.1186/1742-4933-8-5;

Solovieff N, Hartley SW, Baldwin CT, Klings ES, Gladwin MT, Taylor JG, Kato GJ, Farrer LA, Steinberg MH, Sebastiani P. Ancestry of African Americans with sickle cell disease. Blood Cells Mol Dis. 2011 Jun 15; 47(1):41-5.View Related Profiles.

Baldwin, Clinton
Klings, Elizabeth
Farrer, Lindsay
Steinberg, Martin
Sebastiani, Paola

PMID: 21546286; PMCID: PMC3116635; DOI: 10.1016/j.bcmd.2011.04.002;

Akinsheye I, Alsultan A, Solovieff N, Ngo D, Baldwin CT, Sebastiani P, Chui DH, Steinberg MH. Fetal hemoglobin in sickle cell anemia. Blood. 2011 Jul 7; 118(1):19-27.View Related Profiles.

Baldwin, Clinton
Chui, David
Ngo, Duyen
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PMID: 21490337; PMCID: PMC3139383; DOI: 10.1182/blood-2011-03-325258;

Farrell JJ, Sherva RM, Chen ZY, Luo HY, Chu BF, Ha SY, Li CK, Lee AC, Li RC, Li CK, Yuen HL, So JC, Ma ES, Chan LC, Chan V, Sebastiani P, Farrer LA, Baldwin CT, Steinberg MH, Chui DH. A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression. Blood. 2011 May 5; 117(18):4935-45.View Related Profiles.

Baldwin, Clinton
Chui, David
Luo, Hong
Farrer, Lindsay
Steinberg, Martin
Sebastiani, Paola
Sherva, Richard

PMID: 21385855; PMCID: PMC3100700; DOI: 10.1182/blood-2010-11-317081;

Hannafon BN, Sebastiani P, de las Morenas A, Lu J, Rosenberg CL. Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer. Breast Cancer Res. 2011; 13(2):R24.View Related Profiles.

De Las Morenas, Antonio
Lu, Jining
Sebastiani, Paola

PMID: 21375733; PMCID: PMC3219184; DOI: 10.1186/bcr2839;

Dworkis DA, Klings ES, Solovieff N, Li G, Milton JN, Hartley SW, Melista E, Parente J, Sebastiani P, Steinberg MH, Baldwin CT. Severe sickle cell anemia is associated with increased plasma levels of TNF-R1 and VCAM-1. Am J Hematol. 2011 Feb; 86(2):220-3.View Related Profiles.

Baldwin, Clinton
Klings, Elizabeth
Hicks, Jacqueline
Steinberg, Martin
Sebastiani, Paola

PMID: 21264913; PMCID: PMC3078643; DOI: 10.1002/ajh.21928;

K. Steiling, M. Berge, P. Sebastiani, G. O’Connor, X. Zhang, G. Liu, J. Xiao, Y. Alekseyev, J. Campbell, H. O. Coxson, J. C. Hogg, A. McWilliams, W. Timens, P. S. Hiemstra, P. J. Sterk, D. Sin, D. Postma, S. Lam, M. E. Lenburg, A. Spira. Proceedings of the American Thoracic Society. Airway Gene Expression as a Molecular Phenotype of COPD. American Thoracic Society. New York. 2011; 8(2):208-208.

Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R, Christensen K, Zmuda JM, Barral S, Lee JH, Simonsick EM, Walston JD, Yashin AI, Hadley E. Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging (Albany NY). 2011 Jan; 3(1):63-76.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 21258136; PMCID: PMC3047140; DOI: 10.18632/aging.100242;

N Solovieff, MH Steinberg,P Sebastiani. Blood. Response: genetic admixture in sickle cell disease. 2011; 118(16):4495-4495.

Solovieff N, Hartley SW, Baldwin CT, Perls TT, Steinberg MH, Sebastiani P. Clustering by genetic ancestry using genome-wide SNP data. BMC Genet. 2010; 11:108.View Related Profiles.

Baldwin, Clinton
Steinberg, Martin
Sebastiani, Paola
Perls, Thomas

PMID: 21143920; PMCID: PMC3018397; DOI: 10.1186/1471-2156-11-108;

Minniti CP, Eckman J, Sebastiani P, Steinberg MH, Ballas SK. Leg ulcers in sickle cell disease. Am J Hematol. 2010 Oct; 85(10):831-3.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola

PMID: 20872960; PMCID: PMC2953786; DOI: 10.1002/ajh.21838;

Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Genetic signatures of exceptional longevity in humans. Science. 2010 Jul 1; 2010.View Related Profiles.

Baldwin, Clinton
Steinberg, Martin
Montano, Monty
Sebastiani, Paola
Myers, Richard
Andersen, Stacy
Perls, Thomas

PMID: 20595579; DOI: 10.1126/science.1190532;

Graham K, de las Morenas A, Tripathi A, King C, Kavanah M, Mendez J, Stone M, Slama J, Miller M, Antoine G, Willers H, Sebastiani P, Rosenberg CL. Gene expression in histologically normal epithelium from breast cancer patients and from cancer-free prophylactic mastectomy patients shares a similar profile. Br J Cancer. 2010 Apr 13; 102(8):1284-93.View Related Profiles.

De Las Morenas, Antonio
Antoine, Gregory
Mendez, Jane
Slama, Jaromir
Kavanah, Maureen
Sebastiani, Paola

PMID: 20197764; PMCID: PMC2855998; DOI: 10.1038/sj.bjc.6605576;

Sebastiani P, Perls TT. Prediction models that include genetic data. Circ Cardiovasc Genet. 2010 Feb; 3(1):1-2.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 20160188; PMCID: PMC2895327; DOI: 10.1161/CIRCGENETICS.110.937862;

P. Sebastiani, J. N. Milton, L. Wang. Problem Solving Handbook in Computational Biology and Bioinformatics ( L. S. Heath, N. Ramakrishnan, eds.). Designing microarray experiments. 2010; 271-290.
P. Sebastiani, N Solovief. Problem Solving Handbook in Computational Biology and Bioinformatics (L. S. Heath, N. Ramakrishnan, eds.). Genome Wide Association Studies. 2010; 159-178.

Sebastiani P, Solovieff N, Hartley SW, Milton JN, Riva A, Dworkis DA, Melista E, Klings ES, Garrett ME, Telen MJ, Ashley-Koch A, Baldwin CT, Steinberg MH. Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. Am J Hematol. 2010 Jan; 85(1):29-35.View Related Profiles.

Baldwin, Clinton
Klings, Elizabeth
Hicks, Jacqueline
Steinberg, Martin
Sebastiani, Paola

PMID: 20029952; PMCID: PMC2903007; DOI: 10.1002/ajh.21572;

Solovieff N, Milton JN, Hartley SW, Sherva R, Sebastiani P, Dworkis DA, Klings ES, Farrer LA, Garrett ME, Ashley-Koch A, Telen MJ, Fucharoen S, Ha SY, Li CK, Chui DH, Baldwin CT, Steinberg MH. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. Blood. 2010 Mar 4; 115(9):1815-22.View Related Profiles.

Baldwin, Clinton
Chui, David
Klings, Elizabeth
Hicks, Jacqueline
Farrer, Lindsay
Steinberg, Martin
Sebastiani, Paola
Sherva, Richard

PMID: 20018918; PMCID: PMC2832816; DOI: 10.1182/blood-2009-08-239517;

Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One. 2009; 4(12):e8210.View Related Profiles.

Baldwin, Clinton
Terry, Dellara
Steinberg, Martin
Montano, Monty
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 20011587; PMCID: PMC2788130; DOI: 10.1371/journal.pone.0008210;

Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol Genomics. 2010 Mar 3; 41(1):1-8.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Schembri, Frank
Liu, Gang
O'Connor, George
Lenburg, Marc
Sebastiani, Paola
Zhang, Xiaoling
Alekseyev, Yuriy
Dumas, Yves-Martine

PMID: 19952278; PMCID: PMC2841495; DOI: 10.1152/physiolgenomics.00167.2009;

Sebastiani P, Hadley EC, Province M, Christensen K, Rossi W, Perls TT, Ash AS. A family longevity selection score: ranking sibships by their longevity, size, and availability for study. Am J Epidemiol. 2009 Dec 15; 170(12):1555-62.View Related Profiles.

Sebastiani, Paola
Perls, Thomas

PMID: 19910380; PMCID: PMC2800272; DOI: 10.1093/aje/kwp309;

Emery LA, Tripathi A, King C, Kavanah M, Mendez J, Stone MD, de las Morenas A, Sebastiani P, Rosenberg CL. Early dysregulation of cell adhesion and extracellular matrix pathways in breast cancer progression. Am J Pathol. 2009 Sep; 175(3):1292-302.View Related Profiles.

De Las Morenas, Antonio
Mendez, Jane
Kavanah, Maureen
Stone, Michael
Sebastiani, Paola

PMID: 19700746; PMCID: PMC2731147; DOI: 10.2353/ajpath.2009.090115;

Sebastiani P, Timofeev N, Dworkis DA, Perls TT, Steinberg MH. Genome-wide association studies and the genetic dissection of complex traits. Am J Hematol. 2009 Aug; 84(8):504-15.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola
Perls, Thomas

PMID: 19569043; PMCID: PMC2895326; DOI: 10.1002/ajh.21440;

Bais M, McLean J, Sebastiani P, Young M, Wigner N, Smith T, Kotton DN, Einhorn TA, Gerstenfeld LC. Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. PLoS One. 2009; 4(5):e5393.View Related Profiles.

Kotton, Darrell
Gerstenfeld, Louis
Bais, Manish
Sebastiani, Paola
Einhorn, Thomas

PMID: 19415118; PMCID: PMC2673045; DOI: 10.1371/journal.pone.0005393;

Gerhardinger C, Dagher Z, Sebastiani P, Park YS, Lorenzi M. The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy. Diabetes. 2009 Jul; 58(7):1659-67. PMID: 19401417; PMCID: PMC2699853; DOI: 10.2337/db08-1008;

Givens JL, Frederick M, Silverman L, Anderson S, Senville J, Silver M, Sebastiani P, Terry DF, Costa PT, Perls TT. Personality traits of centenarians' offspring. J Am Geriatr Soc. 2009 Apr; 57(4):683-5.View Related Profiles.

Terry, Dellara
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 19392961; PMCID: PMC2895990; DOI: 10.1111/j.1532-5415.2009.02189.x;

Zhao Z, Timofeev N, Hartley SW, Chui DH, Fucharoen S, Perls TT, Steinberg MH, Baldwin CT, Sebastiani P. Imputation of missing genotypes: an empirical evaluation of IMPUTE. BMC Genet. 2008; 9:85.View Related Profiles.

Baldwin, Clinton
Chui, David
Steinberg, Martin
Sebastiani, Paola
Perls, Thomas

PMID: 19077279; PMCID: PMC2636842; DOI: 10.1186/1471-2156-9-85;

Nolan VG, Zhang Y, Lash T, Sebastiani P, Steinberg MH. Association between wind speed and the occurrence of sickle cell acute painful episodes: results of a case-crossover study. Br J Haematol. 2008 Nov; 143(3):433-8.View Related Profiles.

Steinberg, Martin
Sebastiani, Paola
Zhang, Yuqing

PMID: 18729854; PMCID: PMC4347894; DOI: 10.1111/j.1365-2141.2008.07354.x;

Sedgewick AE, Timofeev N, Sebastiani P, So JC, Ma ES, Chan LC, Fucharoen G, Fucharoen S, Barbosa CG, Vardarajan BN, Farrer LA, Baldwin CT, Steinberg MH, Chui DH. BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies. Blood Cells Mol Dis. 2008 Nov-Dec; 41(3):255-8.View Related Profiles.

Baldwin, Clinton
Chui, David
Farrer, Lindsay
Steinberg, Martin
Sebastiani, Paola

PMID: 18691915; PMCID: PMC4100606; DOI: 10.1016/j.bcmd.2008.06.007;

Beane J, Sebastiani P, Whitfield TH, Steiling K, Dumas YM, Lenburg ME, Spira A. A prediction model for lung cancer diagnosis that integrates genomic and clinical features. Cancer Prev Res (Phila). 2008 Jun; 1(1):56-64.View Related Profiles.

Spira, Avrum
Beane-Ebel, Jennifer
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Dumas, Yves-Martine

PMID: 19138936; PMCID: PMC4167688; DOI: 10.1158/1940-6207.CAPR-08-0011;

Wang L, Montano M, Rarick M, Sebastiani P. Conditional clustering of temporal expression profiles. BMC Bioinformatics. 2008; 9:147.View Related Profiles.

Montano, Monty
Sebastiani, Paola

PMID: 18334028; PMCID: PMC2335301; DOI: 10.1186/1471-2105-9-147;

Sebastiani P, Wang L, Nolan VG, Melista E, Ma Q, Baldwin CT, Steinberg MH. Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations. Am J Hematol. 2008 Mar; 83(3):189-95.View Related Profiles.

Baldwin, Clinton
Steinberg, Martin
Sebastiani, Paola

PMID: 17918249

Terry DF, Sebastiani P, Andersen SL, Perls TT. Disentangling the roles of disability and morbidity in survival to exceptional old age. Arch Intern Med. 2008 Feb 11; 168(3):277-83.View Related Profiles.

Terry, Dellara
Sebastiani, Paola
Andersen, Stacy
Perls, Thomas

PMID: 18268168; PMCID: PMC2895331; DOI: 10.1001/archinternmed.2007.75;

Abad-Grau MM, Ierache J, Cervino C, Sebastiani P. Evolution and challenges in the design of computational systems for triage assistance. J Biomed Inform. 2008 Jun; 41(3):432-41. PMID: 18337189; PMCID: PMC2486376; DOI: 10.1016/j.jbi.2008.01.007;

Sebastiani P, Zhao Z, Abad-Grau MM, Riva A, Hartley SW, Sedgewick AE, Doria A, Montano M, Melista E, Terry D, Perls TT, Steinberg MH, Baldwin CT. A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples. BMC Genet. 2008; 9:6.View Related Profiles.

Baldwin, Clinton
Terry, Dellara
Steinberg, Martin
Montano, Monty
Sebastiani, Paola
Perls, Thomas

PMID: 18194558; PMCID: PMC2248205; DOI: 10.1186/1471-2156-9-6;

M. Montano, P. Sebastiani. RNA Viruses: Host Gene Responses to Infections (D. Yang, ed.). Efforts to characterize host response to HIV-1 infection. 2008; 3-30.
T. T. Perls, P. Sebastiani. Molecular Biology of Aging (L. Guarente et al., eds.). Genetics of exceptional longevity. Cold Spring Harbor Laboratory Press. 2008; 517-544.

Sebastiani P, Nolan VG, Baldwin CT, Abad-Grau MM, Wang L, Adewoye AH, McMahon LC, Farrer LA, Taylor JG, Kato GJ, Gladwin MT, Steinberg MH. A network model to predict the risk of death in sickle cell disease. Blood. 2007 Oct 1; 110(7):2727-35.View Related Profiles.

Baldwin, Clinton
Farrer, Lindsay
Steinberg, Martin
Sebastiani, Paola

PMID: 17600133; PMCID: PMC1988954; DOI: 10.1182/blood-2007-04-084921;

Sebastiani P, Abad-Grau MM. Bayesian estimates of linkage disequilibrium. BMC Genet. 2007; 8:36. PMID: 17592642; PMCID: PMC1924864; DOI: 10.1186/1471-2156-8-36;

Ferrazzi F, Sebastiani P, Ramoni MF, Bellazzi R. Bayesian approaches to reverse engineer cellular systems: a simulation study on nonlinear Gaussian networks. BMC Bioinformatics. 2007; 8 Suppl 5:S2. PMID: 17570861; PMCID: PMC1892090; DOI: 10.1186/1471-2105-8-S5-S2;

Montano M, Flanagan JN, Jiang L, Sebastiani P, Rarick M, LeBrasseur NK, Morris CA, Jasuja R, Bhasin S. Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul; 92(7):2793-802.View Related Profiles.

Montano, Monty
Sebastiani, Paola
Bhasin, Shalender

PMID: 17440010

Spira A, Beane JE, Shah V, Steiling K, Liu G, Schembri F, Gilman S, Dumas YM, Calner P, Sebastiani P, Sridhar S, Beamis J, Lamb C, Anderson T, Gerry N, Keane J, Lenburg ME, Brody JS. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat Med. 2007 Mar; 13(3):361-6.View Related Profiles.

Spira, Avrum
Schembri, Frank
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Dumas, Yves-Martine

PMID: 17334370

P. Sebastiani, T. T. Perls . Bayesian Belief Networks: A Practical Guide to Applications (O. Pourret, P. Nam and B. G. Marcot, eds.). Complex genetic models. Wiley Publishers. New York. 2007; 53-72.
P. Sebastiani, M. Abad. Systems Bioinformatics: An Engineering Case-Based Approach (G Alterowitz and M. F. Ramoni, eds.). Bayesian networks for genetics analysis. Artech House. Boston. 2007; 205-228.
M. M. Abad-Grau, P. Sebastiani. Lecture Notes in Computer Science: Proceedings of Computation and Simulation in Modelling Biological Systems. Multivariate imputation of genotype data using short and long range disequilibrium. 2007; 187-194.

Beane J, Sebastiani P, Liu G, Brody JS, Lenburg ME, Spira A. Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression. Genome Biol. 2007; 8(9):R201.View Related Profiles.

Spira, Avrum
Liu, Gang
Beane-Ebel, Jennifer
Brody, Jerome
Lenburg, Marc
Sebastiani, Paola

PMID: 17894889; PMCID: PMC2375039; DOI: 10.1186/gb-2007-8-9-r201;

Abad-Grau MM, Montes R, Sebastiani P. Building chromosome-wide LD maps. Bioinformatics. 2006 Aug 15; 22(16):1933-4. PMID: 16782726; PMCID: PMC2893229; DOI: 10.1093/bioinformatics/btl288;

Sebastiani P, Mandl KD, Szolovits P, Kohane IS, Ramoni MF. A Bayesian dynamic model for influenza surveillance. Stat Med. 2006 Jun 15; 25(11):1803-16; discussion 1817-25. PMID: 16645996; PMCID: PMC4128871; DOI: 10.1002/sim.2566;

Nolan VG, Adewoye A, Baldwin C, Wang L, Ma Q, Wyszynski DF, Farrell JJ, Sebastiani P, Farrer LA, Steinberg MH. Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway. Br J Haematol. 2006 Jun; 133(5):570-8.View Related Profiles.

Baldwin, Clinton
Farrer, Lindsay
Steinberg, Martin
Sebastiani, Paola

PMID: 16681647; PMCID: PMC1679888; DOI: 10.1111/j.1365-2141.2006.06074.x;

Montano M, Rarick M, Sebastiani P, Brinkmann P, Russell M, Navis A, Wester C, Thior I, Essex M. Gene-expression profiling of HIV-1 infection and perinatal transmission in Botswana. Genes Immun. 2006 Jun; 7(4):298-309.View Related Profiles.

Russell, Matthew
Montano, Monty
Sebastiani, Paola

PMID: 16691187; PMCID: PMC7091840; DOI: 10.1038/sj.gene.6364297;

Rarick M, McPheeters C, Bright S, Navis A, Skefos J, Sebastiani P, Montano M. Evidence for cross-regulated cytokine response in human peripheral blood mononuclear cells exposed to whole gonococcal bacteria in vitro. Microb Pathog. 2006 Jun; 40(6):261-70.View Related Profiles.

Skefos, Jerry
Montano, Monty
Sebastiani, Paola

PMID: 16626926

P. Sebastiani, J. Jeneralcuk, M. F. Ramoni . Screening ( A. Dean and S Lewis, eds.). Design and analysis of screening experiments with microarrays. Springer Verlag. New York. 2006; 115-138.
F. Ferrazzi, P. Sebastiani, I. S. Kohane, M. F. Ramoni, R. Bellazzi. 19th IEEE Symposium on Computer-Based Medical Systems (CBMS’06). Dynamic Bayesian networks in modelling cellular systems: a critical appraisal on simulated data. 2006; 544-549.
L. Wang, M. F. Ramoni, P. Sebastiani. Lecture Notes in Computer Science: Research in Computational Molecular Biology: 10th Annual International Conference, (RECOMB 2006). Clustering short gene expression profiles. 2006; 60-68.
M. M. Abad and P. Sebastiani. Lecture Notes in Computer Science: Modeling Decisions for Artificial Intelligence: 3rd International Conference, (MDAI 2006). Bayesian correction for SNP ascertainment bias. 2006; 262-273.
F. Ferrazzi, R. Amici, R., P. Sebastiani, I. S. Kohane, M. F. Ramoni and R. Bellazzi . Genomic Signal Processing and Statistics, (GENSIPS 2006). Can we use linear Gaussian networks to model dynamic interactions among genes? Results from a simulation study. 2006; 13-14.
F. Ferrazzi, P. Sebastiani, R. Bellazzi, I.S. Kohane, M. F. Ramoni. Proceedings of Intelligent Data Analysis in Medicine and Pharmacology (IDAMAP 2006). Identification of feedback structures from gene expression time series. 2006; 57-60.
Sebastiani P, Xie X, Ramoni MF. Bayesian analysis of comparative microarray experiments by model averaging. Bayesian analysis. 2006; 1(4):707-732. View Publication

Montano M, Rarick M, Sebastiani P, Brinkmann P, Skefos J, Ericksen R. HIV-1 burden influences host response to co-infection with Neisseria gonorrhoeae in vitro. Int Immunol. 2006 Jan; 18(1):125-37.View Related Profiles.

Skefos, Jerry
Montano, Monty
Sebastiani, Paola

PMID: 16352629

Wang L, Ramoni MF, Mandl KD, Sebastiani P. Factors affecting automated syndromic surveillance. Artif Intell Med. 2005 Jul; 34(3):269-78. PMID: 16023563

Baldwin C, Nolan VG, Wyszynski DF, Ma QL, Sebastiani P, Embury SH, Bisbee A, Farrell J, Farrer L, Steinberg MH. Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. Blood. 2005 Jul 1; 106(1):372-5.View Related Profiles.

Baldwin, Clinton
Farrer, Lindsay
Steinberg, Martin
Sebastiani, Paola

PMID: 15784727; PMCID: PMC1895132; DOI: 10.1182/blood-2005-02-0548;

Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH. Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia. Nat Genet. 2005 Apr; 37(4):435-40.View Related Profiles.

Baldwin, Clinton
Steinberg, Martin
Sebastiani, Paola

PMID: 15778708; PMCID: PMC2896308; DOI: 10.1038/ng1533;

Klings ES, Safaya S, Adewoye AH, Odhiambo A, Frampton G, Lenburg M, Gerry N, Sebastiani P, Steinberg MH, Farber HW. Differential gene expression in pulmonary artery endothelial cells exposed to sickle cell plasma. Physiol Genomics. 2005 May 11; 21(3):293-8.View Related Profiles.

Klings, Elizabeth
Farber, Harrison
Lenburg, Marc
Steinberg, Martin
Sebastiani, Paola

PMID: 15741505

P. Sebastiani, M. F. Ramoni. Encyclopedia of Data Warehousing and Mining. Learning Bayesian networks. Kluwer. Amsterdam. 2005; 2:674-678.
P. Sebastiani, M. Abad, M. F. Ramoni. The Data Mining and Knowledge Discovery Handbook. Bayesian networks. 2005; 193-230.
P. Sebastiani, M. Abad and M. F. Ramoni. Genomic Signal Processing and Statistics (Dougherty, E. R., Shmulevich, I., Chen, J., Wang, Z. J., Eds.). Bayesian networks for genomic analysis. 2005; 281-320.
Sebastiani P, Ramoni F. Journal of Multivariate analysis. Normative selection of Bayesian networks. 2005; 93(2):340-357. View Publication

Sebastiani P, Abad MM, Alpargu G, Ramoni MF. Robust transmission/disequilibrium test for incomplete family genotypes. Genetics. 2004 Dec; 168(4):2329-37. PMID: 15611196; PMCID: PMC1448738

P. Sebastiani, K. Mandl. Data Mining: Next Generation Challenges and Future Directions (H. Kargupta A. Joshi K. Sivakumar , Y. Yesha, Eds). Biosurveillance and outbreak detection. MIT Press. Cambridge. 2004; 185-198.
P. Sebastiani, L. Wang, K. D. Mandl, M. F. Ramoni. MMWR: Mortality and Morbidity Weekly Reports (Supplement). Improving outbreak detection by signal integration. 2004; 257:57.
S. Lodi, P. Sebastiani, D. Cocchi , M. F. Ramoni. New Developments in Classification and Data Analysis. Bayesian clustering of gene expression dynamics: an application. Springer Verlag. New York. 2004; 259-266.

Sebastiani P, Yu YH, Ramoni MF. Bayesian machine learning and its potential applications to the genomic study of oral oncology. Adv Dent Res. 2003 Dec; 17:104-8. PMID: 15126219

Mandl KD, Overhage JM, Wagner MM, Lober WB, Sebastiani P, Mostashari F, Pavlin JA, Gesteland PH, Treadwell T, Koski E, Hutwagner L, Buckeridge DL, Aller RD, Grannis S. Implementing syndromic surveillance: a practical guide informed by the early experience. J Am Med Inform Assoc. 2004 Mar-Apr; 11(2):141-50. PMID: 14633933; PMCID: PMC353021

Sebastiani P, Lazarus R, Weiss ST, Kunkel LM, Kohane IS, Ramoni MF. Minimal haplotype tagging. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9900-5. PMID: 12900503; PMCID: PMC187880

Sebastiani P, Gussoni E, Kohane IS, Ramoni MF. Statistical challenges in functional genomics. Statistical Science. 2003; 1(18):33-70. View Publication
M. F. Ramoni , P. Sebastiani. Intelligent Data Analysis. An Introduction (M. R. Berthold, D.J. Hand, eds.). Bayesian methods in intelligent data analysis. Springer Verlag. New York. 2003; 131-168.
P. Sebastiani, M. F. Ramoni, I. Kohane. The Analysis of Gene Expression Data: Methods and Software, (Parmigiani, G., Garrett, E. S., Irizarry, R., and Zeger, S., eds.). Bayesian clustering of gene expression dynamics. Springer Verlag. New York. 2003; 400-427.
S. Lodi, D. Cocchi, P. Sebastiani. Book of short papers. CLADAG 2003: Meeting of the Classification and Data Analysis Group of the Italian Statistical Society. Applications of Bayesian clustering by dynamics. CLUEB. Bologna. 2003; 249-252.
T. Rath, M. Carreras and P. Sebastiani. Lecture Notes in Computer Science: Proceedings of the Fifth International Symposium on Intelligent Data Analysis. Automated detection of influenza epidemics with Hidden Markov Models. 2003; 521-531.
P. Sebastiani, E. Gussoni, I. S. Kohane, M. F. Ramoni. Rejoinder. Statistical Science. 2003; 18:69-70.

Ramoni MF, Sebastiani P, Kohane IS. Cluster analysis of gene expression dynamics. Proc Natl Acad Sci U S A. 2002 Jul 9; 99(14):9121-6. PMID: 12082179; PMCID: PMC123104

M. F. Ramoni, P. Sebastiani, P. Cohen. Bayesian clustering by dynamics. Machine Learning. 2002; 47(1):91-121.
C.T. Morrison, P. Cohen, P. Sebastiani . Proceedings of the 2nd International Conference on Development and Learning. On the development of visual object memory: the stay/go decision problem. IEEE Computer Society Press. 2002; 239-244.

Ramoni M, Sebastiani P, Dybowski R. Robust outcome prediction for intensive-care patients. Methods Inf Med. 2001 Mar; 40(1):39-45. PMID: 11310158

P. Sebastiani, M. F. Ramoni. Common trends in European school population. Research in Official Statistics. 2001; 4(1):169-183.
Sebastiani P and Ramoni MF. Bayesian selection of decomposable models with incomplete data. Journal of the American Statistical Association. 2001; 96(456):1375-1386. View Publication
P. Sebastiani, M. F. Ramoni, P. Cohen. Proceedings of the 5th Workshop on Case Studies in Bayesian Statistics. Bayesian analysis of sensory inputs of a mobile robot. Springer. New York. 2001; 363-379.
P. Sebastiani, H. P. Wynn. MaxEnt 2000: Twentieth International Workshop on Bayesian Inference and Maximum Entropy in Science and Engineering. Design to maximize information. AIP Conference Proceedings. 2001; 192-203.
H. P. Wynn, P. Sebastiani. MaxEnt 2000: Twentieth International Workshop on Bayesian Inference and Maximum Entropy in Science and Engineering. The quantization of the attention function under a Bayes information theoretic model. AIP Conference Proceedings. 2001; 159-168.
M. Ramoni, P. Sebastiani. Bayesian Methods: Selected Papers from Sixth World Meeting of the International Society for Bayesian Analysis (ISBA). Automated Bayesian modeling. European Communities. Luxembourg. 2001; 429-438.
P. Sebastiani, M. F. Ramoni. Bayesian Methods: Selected Papers from Sixth World Meeting of the International Society for Bayesian Analysis (ISBA). Bayesian clustering by dynamics of European socioeconomic indicators. European Communities. Luxembourg. 2001; 479-488.
P. Sebastiani, M. F. Ramon. Proceeding of the 18th International Conference on Machine Learning (ICML-2001). Clustering continuous time series. Morgan Kaufmann. San Francisco. 2001; 497-504.
P. Sebastiani, M. F. Ramoni. On the use of Bayesian networks to analyze survey data. Research in Official Statistics. 2001; 4(1):53-64.
Ramoni MF and Sebastiani P. Robust learning with missing data. Machine Learning. 2001; 45(2):147-170. View Publication
Ramoni MF and Sebastiani P. Robust Bayes Classifiers. Artificial Intelligence. 2001; 125(1):209-226. View Publication
. P. Sebastiani, M. F. Ramoni, P. Cohen. Sequence Learning: Paradigms, Algorithms, and Applications (L. Giles, R. Sun, eds.). Sequence learning via Bayesian clustering by dynamics. Springer Verlag. New York. 2001; 11-34.
P. Cohen, M. F. Ramoni, P. Sebastiani, J. Warwick. Proceedings of the 4th International Conference on Autonomous Agents (Agents 2000). Unsupervised clustering of robot activities: a Bayesian approach. ACM Press. New York. 2000; 134-136.
P. Sebastiani, M. F. Ramoni. Proceedings of the 14th Conference for Statistical Computing (Compstat 2000). Short Papers. Official statistics via Bayesian networks. Statistica. Netherlandica. 2000.
M. F. Ramoni, P. Sebastiani, P. Cohen. Proceeding of the National Conference of the American Association for Artificial Intelligence (AAAI-2000). Multivariate Bayesian clustering by dynamic. AAAI Press/The MIT Press. Menlo Park/Cambridge. 2000; 633-638.
P. Sebastiani, M. F. Ramoni, A. Crea. Profiling customers from in-house data. ACM SIGKDD Explorations. 2000; 1:91-96.
P. Sebastiani, M. F. Ramoni. Bayesian inference with missing data using bound and collapse. Journal of Computational and Graphical Statistics. 2000; 9:779-800.
Sebastiani P and Wynn HP. Maximum entropy sampling and optimal Bayesian experimental design. Journal of the Royal Statistical Society: Series B. 2000; 62(1). View Publication
M. F. Ramoni, P. Sebastiani. Proceedings of Uncertainty 99: The 7th International Workshop on Artificial Intelligence and Statistics. Learning conditional probabilities from incomplete data: an experimental comparison. Morgan Kaufman. San Mateo. 1999; 260-265.
P. Sebastiani and M. F. Ramoni. Proceedings of Uncertainty 99: The 7th International Workshop on Artificial Intelligence and Statistics. Model folding for data subject to nonresponse. Morgan Kaufman. San Mateo. 1999; 287-292.
P. Sebastiani, M. F. Ramoni, P. Cohen. Proceedings of International Joint Conference in Artificial Intelligence Workshop on Neural, Symbolic and Reinforcement Methods for Sequence Learning. Unsupervised classification of sensory input in a mobile robot. AAAI Press. Cambridge. 1999; 23-28.
P. Sebastiani, M. F. Ramoni, P. Cohen, J. Warwick, J. Davis. Proceedings of the 3rd International Symposium on Intelligent Data Analysis. Discovering dynamics using Bayesian clustering. Springer. New York. 1999; 199-210.
Dawid AP and Sebastiani P. Coherent dispersion criteria for optimal experimental design. Annals of Statistics. 1999; 65-81. View Publication
M. F. Ramoni, P. Sebastiani. Parameter estimation in Bayesian networks from incomplete databases. Intelligent Data Analysis. An International Journal. 1998; 2:139-160.
P. Sebastiani, M. F. Ramoni. Proceedings of the 14th Conference on Uncertainty in Artificial Intelligence. Decision theoretic foundations of graphical model selection. Morgan Kaufman. San Mateo. 1998; 464-471.
P. Sebastiani, H.P. Wynn. Proceedings of the 1998 Conference on Model Oriented Data Analysis and Experimental Design. Risk based optimal designs. Physica Verlag. Heidelberg. 1998; 247-257.
P. Sebastiani, M. F. Ramoni. Proceedings of the 13th Conference for Statistical Computing (Compstat98). Induction of graphical models from incomplete samples. Physica Verlag. Heidelberg. 1998; 449-454.
M. F. Ramoni, P. Sebastiani. Proceedings of the 2nd International Symposium on Intelligent Data Analysis. The use of exogenous knowledge to learn Bayesian networks from incomplete databases. Springer. New York. 1997; 537-548.
M. F. Ramoni, P. Sebastiani. Proceedings of the 13th Conference on Uncertainty in Artificial Intelligence. Learning Bayesian networks from incomplete databases. Morgan Kaufman. San Mateo. 1997; 401-408.
M. F. Ramoni, P. Sebastiani. Proceedings of the 6th Workshop on AI & Statistics. Robust learning with missing data. Preliminary Papers. Ft. Lauderdale. 1997; 339-406.
P. Sebastiani, R. Settimi. A note on D-optimal designs for a logistic regression model. Journal Statistical Planning and Inference. 1997; 59:359-368.
R.G. Cowell, A.P. Dawid, P. Sebastiani. Bayesian Statistics 5. A comparison of sequential learning methods for incomplete data. Oxford University Press. New York. 1996; 533-542.
P. Sebastiani. On the derivatives of matrix powers. SIAM Journal of Matrix Analysis. 1996; 17:640-648.
S. Colazza, M.G. Rosi, P. Sebastiani, M. Ursini. Host discrimination in the egg Parasitoids Trissolcus Basalis. Acta Aecologica. 1996; 17:109-125.
Eaton M, Giovagnoli A and Sebastiani P. A predictive approach to the Bayesian design problem with application to normal regression models. Biometrika. 1996; 83(1):111-125. View Publication
P. Sebastiani, M. Ursini. Atti della XXXVII Riunione Scientifica della Societ`a Italiana di Statistica. Modeling the behaviour of a parasitoid insect. SIS. 1994; 171-177.
P. Sebastiani, R. Settimi. Proceedings of the 9th International Workshop on Statistical Modeling. Planning experiments in non linear situation. Exeter. 1994; 1994.
Burridge J and Sebastiani P. D-optimal designs for generalised linear models with variance proportional to the square of the mean. Biometrika. 1994; 81(2):295-304. View Publication
A. Forcina, P. Sebastiani. Proceedings of the 8th International Workshop on Statistical Modeling. Graphical analysis of conditional independence. Leuven. 1993; 85-87.
P Sebastiani. Piani di Esperimento Ottimi per Modelli Lineari Generalizzati. Rome. 1992.
A. Giovagnoli, P. Sebastiani. Journal of the Italian Statistical Society. Review of the book by A.C.Atkinson and Donev, “Optimum Experimental Designs”. 1992; 1:425-426.
M. I. Taticchi, P. Pandolfi, M. T. Biondi, P. Sebastiani. Population dynamics of Daphnia Galeata Sars and Bosmina Longirostris Muell in Trasimeno lake. Bollettino di Zoologia. 1992; 59:427-435.
P. Sebastiani. Atti del Convegno SIS “Sviluppi metodologici nei diversi approcci all’inferenza statistica”. Optimal designs for generalized linear models. Pitagora Bologn. Cagliari. 1991; 1:167-170.
A. Giovagnoli, P. Sebastiani. Experimental designs for mean and variance estimation in variance component models. Computational Statistics and Data Analysis. 1990; 10:93.
A. Giovagnoli, P. Sebastiani. Introduzione ai modelli lineari con pi`u componenti di varianza. Quaderni di Statistica e Matematica Applicata. 1988; 4:79-112.
P. Sebastiani. Modelli Lineari con Piu’ Componenti di Varianza. Perugia. 1987.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 278 publications over 36 distinct years, with a maximum of 18 publications in 2012

Bar chart showing 278 publications over 36 distinct years, with a maximum of 18 publications in 2012

Year	Publications
1987	1
1988	1
1990	1
1991	1
1992	3
1993	1
1994	3
1996	4
1997	4
1998	4
1999	5
2000	6
2001	13
2002	3
2003	9
2004	4
2005	9
2006	12
2007	9
2008	11
2009	9
2010	8
2011	11
2012	18
2013	14
2014	7
2015	13
2016	10
2017	12
2018	7
2019	14
2020	7
2021	12
2022	14
2023	7
2024	11