Keywords
Last Name

Elizabeth S. Klings, MD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-8679
ORCID ORCID Icon0000-0003-4879-720X
Other Positions
TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine

 Research Expertise & Professional Interests
Dr. Klings is an Assistant Professor in the Department of Medicine. She attends in the Medical Intensive Care Unit and on the Pulmonary Consultation Service at Boston Medical Center. Additionally, she has a clinic in the Pulmonary Hypertension Center at Boston Medical Center where she is involved in the diagnosis, evaluation and treatment of patients with pulmonary hypertension. She has special interest in the management of patients with chronic dyspnea and is the Medical Director of the Pulmonary Rehabilitation Program.

Dr. Klings’ research since fellowship has focused on pathogenesis of pulmonary vascular complications of sickle cell disease. She is an NIH-funded Principal Investigator .in the Pulmonary Center collaborating with the Boston Comprehensive Sickle Cell Center,Sickle Cell Genetics Research group and the Cardiovascular Proteomics Center at Boston University. She has phenotypically screened close to 200 sickle cell patients at Boston Medical Center for the presence of pulmonary hypertension and has begun to study the role that genetic polymorphisms play in the pathogenesis of this disease process. Along with her collaborators at Boston University, she was instrumental in formation of the multi-center SickleGen consortium which has brought together the largest cohort of prospectively collected SCD patients with well-established cardiopulmonary phenotypes for genetic studies. Known nationally as a leader in the care and treatment of patients with sickle cell disease and pulmonary hypertension, she headed a committee of 25 hematologists, pulmonologists and cardiologists to develop clinical guidelines for the care and treatment of these patients, which is currently under review by the American Thoracic Society.

 Self-Described Keywords
  • anemia, sickle cell
  • endothelium
  • pulmonary hypertension
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Klings ES, Morris CR, Hsu LL, Castro O, Gladwin MT, Mubarak KK. Pulmonary hypertension of sickle cell disease beyond classification constraints. J Am Coll Cardiol. 2014 Jul 1; 63(25 Pt A):2881-2.
    View in: PubMed
  2. Klings ES, Machado RF, Barst RJ, Morris CR, Mubarak KK, Gordeuk VR, Kato GJ, Ataga KI, Gibbs JS, Castro O, Rosenzweig EB, Sood N, Hsu L, Wilson KC, Telen MJ, Decastro LM, Krishnamurti L, Steinberg MH, Badesch DB, Gladwin MT. An official american thoracic society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease. Am J Respir Crit Care Med. 2014 Mar 15; 189(6):727-40.
    View in: PubMed
  3. Klings ES, Vichinsky EP, Morris CR. Response to "Efficacy and safety of sildenafil for the treatment of severe pulmonary hypertension in patients with hemoglobinopathies: results from a long-term follow up " Haematologica 2014;99(2):e17-18. Haematologica. 2014 Feb; 99(2):e19.
    View in: PubMed
  4. Morris CR, Kim HY, Wood J, Porter JB, Klings ES, Trachtenberg FL, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Singer ST, Taher A, Neufeld EJ, Thompson AA, Sachdev V, Larkin S, Suh JH, Kuypers FA, Vichinsky EP. Sildenafil therapy in thalassemia patients with Doppler-defined risk of pulmonary hypertension. Haematologica. 2013 Sep; 98(9):1359-67.
    View in: PubMed
  5. Klings ES, Morris CR. Making it personal: using genomics to predict pulmonary hypertension in sickle cell disease. Am J Respir Crit Care Med. 2012 Aug 15; 186(4):304-5.
    View in: PubMed
  6. Milton JN, Sebastiani P, Solovieff N, Hartley SW, Bhatnagar P, Arking DE, Dworkis DA, Casella JF, Barron-Casella E, Bean CJ, Hooper WC, DeBaun MR, Garrett ME, Soldano K, Telen MJ, Ashley-Koch A, Gladwin MT, Baldwin CT, Steinberg MH, Klings ES. A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia. PLoS One. 2012; 7(4):e34741.
    View in: PubMed
  7. Safaya S, Steinberg MH, Klings ES. Monocytes from sickle cell disease patients induce differential pulmonary endothelial gene expression via activation of NF-?B signaling pathway. Mol Immunol. 2012 Feb; 50(1-2):117-23.
    View in: PubMed
  8. Hawkins F, Ebel N, Sorescu GP, McMahon L, Sprinz P, Klings ES. Keeping it in the family: three relatives with HbSC disease and simultaneous acute pulmonary emboli. Am J Hematol. 2012 Jan; 87(1):101-4.
    View in: PubMed
  9. Solovieff N, Hartley SW, Baldwin CT, Klings ES, Gladwin MT, Taylor JG, Kato GJ, Farrer LA, Steinberg MH, Sebastiani P. Ancestry of African Americans with sickle cell disease. Blood Cells Mol Dis. 2011 Jun 15; 47(1):41-5.
    View in: PubMed
  10. Dworkis DA, Klings ES, Solovieff N, Li G, Milton JN, Hartley SW, Melista E, Parente J, Sebastiani P, Steinberg MH, Baldwin CT. Severe sickle cell anemia is associated with increased plasma levels of TNF-R1 and VCAM-1. Am J Hematol. 2011 Feb; 86(2):220-3.
    View in: PubMed
  11. Akinsheye I, Klings ES. Sickle cell anemia and vascular dysfunction: the nitric oxide connection. J Cell Physiol. 2010 Sep; 224(3):620-5.
    View in: PubMed
  12. Sebastiani P, Solovieff N, Hartley SW, Milton JN, Riva A, Dworkis DA, Melista E, Klings ES, Garrett ME, Telen MJ, Ashley-Koch A, Baldwin CT, Steinberg MH. Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. Am J Hematol. 2010 Jan; 85(1):29-35.
    View in: PubMed
  13. Solovieff N, Milton JN, Hartley SW, Sherva R, Sebastiani P, Dworkis DA, Klings ES, Farrer LA, Garrett ME, Ashley-Koch A, Telen MJ, Fucharoen S, Ha SY, Li CK, Chui DH, Baldwin CT, Steinberg MH. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. Blood. 2010 Mar 4; 115(9):1815-22.
    View in: PubMed
  14. Klings ES, Lowry MH, Li G, Jean JC, Fernandez BO, Garcia-Saura MF, Feelisch M, Joyce-Brady M. Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress. Am J Pathol. 2009 Dec; 175(6):2309-18.
    View in: PubMed
  15. Safaya S, Klings ES, Odhiambo A, Li G, Farber HW, Steinberg MH. Effect of sodium butyrate on lung vascular TNFSF15 (TL1A) expression: differential expression patterns in pulmonary artery and microvascular endothelial cells. Cytokine. 2009 Apr; 46(1):72-8.
    View in: PubMed
  16. Klings ES, Anton Bland D, Rosenman D, Princeton S, Odhiambo A, Li G, Bernard SA, Steinberg MH, Farber HW. Pulmonary arterial hypertension and left-sided heart disease in sickle cell disease: clinical characteristics and association with soluble adhesion molecule expression. Am J Hematol. 2008 Jul; 83(7):547-53.
    View in: PubMed
  17. Klings ES. Pulmonary hypertension of sickle cell disease: more than just another lung disease. Am J Hematol. 2008 Jan; 83(1):4-5.
    View in: PubMed
  18. Morris CR, Suh JH, Hagar W, Larkin S, Bland DA, Steinberg MH, Vichinsky EP, Shigenaga M, Ames B, Kuypers FA, Klings ES. Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease. Blood. 2008 Jan 1; 111(1):402-10.
    View in: PubMed
  19. Odhiambo A, Perlman DH, Huang H, Costello CE, Farber HW, Steinberg MH, McComb ME, Klings ES. Identification of oxidative post-translational modification of serum albumin in patients with idiopathic pulmonary arterial hypertension and pulmonary hypertension of sickle cell anemia. Rapid Commun Mass Spectrom. 2007; 21(14):2195-203.
    View in: PubMed
  20. Klings ES, Wyszynski DF, Nolan VG, Steinberg MH. Abnormal pulmonary function in adults with sickle cell anemia. Am J Respir Crit Care Med. 2006 Jun 1; 173(11):1264-9.
    View in: PubMed
  21. Kane LB, Klings ES. Present and future treatment strategies for pulmonary arterial hypertension : focus on phosphodiesterase-5 inhibitors. Treat Respir Med. 2006; 5(4):271-82.
    View in: PubMed
  22. Adewoye AH, Klings ES, Farber HW, Palaima E, Bausero MA, McMahon L, Odhiambo A, Surinder S, Yoder M, Steinberg MH, Asea A. Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70. Am J Hematol. 2005 Mar; 78(3):240-2.
    View in: PubMed
  23. Klings ES, Safaya S, Adewoye AH, Odhiambo A, Frampton G, Lenburg M, Gerry N, Sebastiani P, Steinberg MH, Farber HW. Differential gene expression in pulmonary artery endothelial cells exposed to sickle cell plasma. Physiol Genomics. 2005 May 11; 21(3):293-8.
    View in: PubMed
  24. Klings ES, Farber HW. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med. 2004 Jun 10; 350(24):2521-2; author reply 2521-2.
    View in: PubMed
  25. Klings ES, Farber HW. The pathogenesis of HIV-associated pulmonary hypertension. Adv Cardiol. 2003; 40:71-82.
    View in: PubMed
  26. Jean JC, Liu Y, Brown LA, Marc RE, Klings E, Joyce-Brady M. Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia. Am J Physiol Lung Cell Mol Physiol. 2002 Oct; 283(4):L766-76.
    View in: PubMed
  27. Forgione MA, Weiss N, Heydrick S, Cap A, Klings ES, Bierl C, Eberhardt RT, Farber HW, Loscalzo J. Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2002 Apr; 282(4):H1255-61.
    View in: PubMed
  28. Klings ES, Christman BW, McClung J, Stucchi AF, McMahon L, Brauer M, Farber HW. Increased F2 isoprostanes in the acute chest syndrome of sickle cell disease as a marker of oxidative stress. Am J Respir Crit Care Med. 2001 Oct 1; 164(7):1248-52.
    View in: PubMed
  29. Klings ES, Farber HW. Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease. Respir Res. 2001; 2(5):280-5.
    View in: PubMed
  30. Strohmeier GR, Walsh JH, Klings ES, Farber HW, Cruikshank WW, Center DM, Fenton MJ. Lipopolysaccharide binding protein potentiates airway reactivity in a murine model of allergic asthma. J Immunol. 2001 Feb 1; 166(3):2063-70.
    View in: PubMed
  31. Klings ES, Farber HW. Current management of primary pulmonary hypertension. Drugs. 2001; 61(13):1945-56.
    View in: PubMed
  32. Klings ES, Farber HW. IV epoprostenol for systemic sclerosis. Chest. 2000 Sep; 118(3):881-2.
    View in: PubMed
  33. Eberhardt RT, Forgione MA, Cap A, Leopold JA, Rudd MA, Trolliet M, Heydrick S, Stark R, Klings ES, Moldovan NI, Yaghoubi M, Goldschmidt-Clermont PJ, Farber HW, Cohen R, Loscalzo J. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest. 2000 Aug; 106(4):483-91.
    View in: PubMed
  34. Klings ES, Farber HW. Epoprostenol for pulmonary hypertension in scleroderma. Ann Intern Med. 2000 Jul 18; 133(2):158.
    View in: PubMed
  35. Klings ES, Hill NS, Ieong MH, Simms RW, Korn JH, Farber HW. Systemic sclerosis-associated pulmonary hypertension: short- and long-term effects of epoprostenol (prostacyclin). Arthritis Rheum. 1999 Dec; 42(12):2638-45.
    View in: PubMed
  36. Hammerman SI, Klings ES, Hendra KP, Upchurch GR, Rishikof DC, Loscalzo J, Farber HW. Endothelial cell nitric oxide production in acute chest syndrome. Am J Physiol. 1999 Oct; 277(4 Pt 2):H1579-92.
    View in: PubMed
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