Elizabeth S. Klings, MD
Associate Professor
Boston University School of Medicine
Dept of Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

MD, New York University School of Medicine



Dr. Klings is an Assistant Professor in the Department of Medicine. She attends in the Medical Intensive Care Unit and on the Pulmonary Consultation Service at Boston Medical Center. Additionally, she has a clinic in the Pulmonary Hypertension Center at Boston Medical Center where she is involved in the diagnosis, evaluation and treatment of patients with pulmonary hypertension. She has special interest in the management of patients with chronic dyspnea and is the Medical Director of the Pulmonary Rehabilitation Program.

Dr. Klings’ research since fellowship has focused on pathogenesis of pulmonary vascular complications of sickle cell disease. She is an NIH-funded Principal Investigator .in the Pulmonary Center collaborating with the Boston Comprehensive Sickle Cell Center,Sickle Cell Genetics Research group and the Cardiovascular Proteomics Center at Boston University. She has phenotypically screened close to 200 sickle cell patients at Boston Medical Center for the presence of pulmonary hypertension and has begun to study the role that genetic polymorphisms play in the pathogenesis of this disease process. Along with her collaborators at Boston University, she was instrumental in formation of the multi-center SickleGen consortium which has brought together the largest cohort of prospectively collected SCD patients with well-established cardiopulmonary phenotypes for genetic studies. Known nationally as a leader in the care and treatment of patients with sickle cell disease and pulmonary hypertension, she headed a committee of 25 hematologists, pulmonologists and cardiologists to develop clinical guidelines for the care and treatment of these patients, which is currently under review by the American Thoracic Society.

Active Staff Privileges
Boston Medical Center
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section



Pfizer Consultant Agreement- Rivipansel
03/17/2014 - 12/31/2019 (PI)
Pfizer, Inc.

A Phase 2, Open-Label, Extension Study to Evaluate the Long-Term Safety and Efficacy of Ubenimex in Patients with Pulmonary Arterial Hypertension (WHO Group 1)
08/24/2016 - 08/23/2019 (PI)
Eiger BioPharmaceuticals, Inc.

A Phase 2, Randomized, Double-BLind, Placebo-Controlled Study of UBEnimex in Patients with Pulmonary ARTerial HYpertension (WHO Group 1) (LIBERTY)
06/10/2016 - 06/09/2019 (PI)
Eiger BioPharmaceuticals, Inc.

PORTICO
12/01/2015 - 12/31/2018 (PI)
Actelion Clinical Operations, Inc.

Potential pharmacokinetic interaction of HIV antiretroviral agents as fixed-dose combinations and riociguat in HIV patients.
12/08/2015 - 12/08/2018 (PI)
Bayer HealthCare Pharmaceuticals

A Study of the Efficacy and Safety of Bardoxolone Methyl in Patients with Connective Tissue Disease-Associated Pulmonary Arterial Hypertension
10/12/2016 - 10/11/2018 (PI)
Reata Pharmaceuticals, Inc.

A prospective, randomized, international, multicenter, double-arm, controlled, open-label study of Riociguat in patients with pulmonary arterial hypertension (PAH) who are on a stable dose of
05/31/2017 - 09/30/2018 (PI)
Bayer HealthCare Pharmaceuticals

Hematopoietic Stem Cell Transplantation for Young Adults with Sickle Cell Disease
09/01/2015 - 07/31/2018 (PI)
Emory University NIH NHLBI
5U01HL128566-02

The efficacy and safety of initial triple versus initial dual oral combination therapy in patients with newly diagnosed pulmonary arterial hypertension: A multi-center, double-blind, placebo
07/15/2015 - 07/14/2018 (PI)
Actelion Pharmaceuticals, Ltd.

REPAIR: Right Ventricular Remodeling in Pulmonary Arterial Hypertension
07/15/2015 - 07/14/2018 (Co-PI)
PI: Harrison W. Farber, MD
Actelion Pharmaceuticals, Ltd.

Showing 10 of 23 results. Show All Results



Yr Title Project-Sub Proj Pubs
2013 Protein biomarkers of pulmonary hypertension in sickle cell disease 5R21HL107993-02 1
2012 Protein biomarkers of pulmonary hypertension in sickle cell disease 1R21HL107993-01A1 1
2011 COMPARATIVE PROTEOMICS OF SICKLE CELL DISEASE-RELATED PULMONARY HYPERTENSION 5P41RR010888-15-5116 236
2010 COMPARATIVE PROTEOMICS OF SICKLE CELL DISEASE-RELATED PULMONARY HYPERTENSION 5P41RR010888-14-6816 236
2009 COMPARATIVE PROTEOMICS OF SICKLE CELL DISEASE-RELATED PULMONARY HYPERTENSION 5P41RR010888-13-6167 236
2009 Gene polymorphism in chronic sickle cell lung disease 5K23HL079003-05 6
2008 COMPARATIVE PROTEOMICS OF SICKLE CELL DISEASE-RELATED PULMONARY HYPERTENSION 5P41RR010888-12-5241 236
2008 Gene polymorphism in chronic sickle cell lung disease 5K23HL079003-04 6
2007 COMPARATIVE PROTEOMICS OF SICKLE CELL DISEASE-RELATED PULMONARY HYPERTENSION 2P41RR010888-11-8062 236
2007 Gene polymorphism in chronic sickle cell lung disease 5K23HL079003-03 6
Showing 10 of 17 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Worsham CM, Martin ST, Nouraie M, Cohen RT, Klings ES. Clinical and Laboratory Findings Associated with Sleep Disordered Breathing in Sickle Cell Disease. Am J Hematol. 2017 Aug 22.View Related Profiles. PMID: 28833466.
  2. Weir NA, Saiyed R, Alam S, Conrey A, Desai HD, George MP, Keeley JH, Klings ES, Mehari A, Taylor JG, Minniti CP, Kato GJ. Prostacyclin-analog therapy in sickle cell pulmonary hypertension. Haematologica. 2017 May; 102(5):e163-e165. PMID: 28126964; DOI: 10.3324/haematol.2015.131227;.
  3. Whitesell PL, Owoyemi O, Oneal P, Nouraie M, Klings ES, Rock A, Mellman TA, Berihun T, Lavella J, Taylor RE, Perrine SP. Sleep-disordered breathing and nocturnal hypoxemia in young adults with sickle cell disease. Sleep Med. 2016 Jun; 22:47-49. PMID: 27544835; PMCID: PMC4994534; DOI: 10.1016/j.sleep.2016.05.006;.
  4. Mehari A, Klings ES. Chronic Pulmonary Complications of Sickle Cell Disease. Chest. 2016 May; 149(5):1313-24. PMID: 26836905; DOI: 10.1016/j.chest.2015.11.016;.
  5. Cohen RT, Klings ES, Strunk RC. Sickle cell disease: wheeze or asthma? Asthma Res Pract. 2015; 1:14.View Related Profiles. PMID: 27965767.
  6. Moy ML, Wayne PM, Litrownik D, Beach D, Klings ES, Davis RB, Yeh GY. Long-term Exercise After Pulmonary Rehabilitation (LEAP): Design and rationale of a randomized controlled trial of Tai Chi. Contemp Clin Trials. 2015 Nov; 45(Pt B):458-67.View Related Profiles. PMID: 26362690; PMCID: PMC4886504; DOI: 10.1016/j.cct.2015.09.004;.
  7. Morris CR, Kim HY, Klings ES, Wood J, Porter JB, Trachtenberg F, Sweeters N, Olivieri NF, Kwiatkowski JL, Virzi L, Hassell K, Taher A, Neufeld EJ, Thompson AA, Larkin S, Suh JH, Vichinsky EP, Kuypers FA. Dysregulated arginine metabolism and cardiopulmonary dysfunction in patients with thalassaemia. Br J Haematol. 2015 Jun; 169(6):887-98. PMID: 25907665; PMCID: PMC4452408; DOI: 10.1111/bjh.13452;.
  8. Klings ES, Kato GJ, Gladwin MT. Management of patients with sickle cell disease. JAMA. 2015 Jan 6; 313(1):91. PMID: 25562274; DOI: 10.1001/jama.2014.15898;.
  9. Ataga KI, Klings ES. Pulmonary hypertension in sickle cell disease: diagnosis and management. Hematology Am Soc Hematol Educ Program. 2014 Dec 5; 2014(1):425-31. PMID: 25696889; DOI: 10.1182/asheducation-2014.1.425;.
  10. Hayes MM, Vedamurthy A, George G, Dweik R, Klings ES, Machado RF, Gladwin MT, Wilson KC, Thomson CC. Pulmonary hypertension in sickle cell disease. Ann Am Thorac Soc. 2014 Nov; 11(9):1488-9.View Related Profiles. PMID: 25423000; DOI: 10.1513/AnnalsATS.201408-405CME;.
Showing 10 of 47 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 47 publications over 19 distinct years, with a maximum of 6 publications in 2014

YearPublications
19992
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20022
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20041
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20093
20102
20113
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20146
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20172
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

anemia, sickle cell
endothelium
pulmonary hypertension

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Boston MA 02118
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