Keywords
Last Name

Martin Joyce-Brady, MD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-4860
ORCID ORCID Icon0000-0002-1898-6002
 Research Expertise & Professional Interests
Basic expertise in lung glutathione metabolism, lung development and antioxidant defense. Clinical expertise in prolonged support of mechanical ventilation, ventilator weaning outcomes, and ventilator associated pneumonia.

 Self-Described Keywords
  • antioxidant defense
  • development
  • glutathione
  • oxidant stress
  • VAP
  • ventilator weaning
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tuzova M, Jean JC, Hughey RP, Brown LA, Cruikshank WW, Hiratake J, Joyce-Brady M. Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma. Front Pharmacol. 2014; 5:179. PMID: 25132819.
    View in: PubMed
  2. Sulis CA, Walkey AJ, Abadi Y, Campbell Reardon C, Joyce-Brady M. Outcomes of a ventilator-associated pneumonia bundle on rates of ventilator-associated pneumonia and other health care-associated infections in a long-term acute care hospital setting. Am J Infect Control. 2014 May; 42(5):536-8. PMID: 24773791.
    View in: PubMed
  3. Jean JC, George E, Kaestner KH, Brown LA, Spira A, Joyce-Brady M. Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. PLoS One. 2013; 8(1):e54806. PMID: 23372771.
    View in: PubMed
  4. Joyce-Brady MF, Tuder RM. Just in the "Bik" of time. Am J Respir Crit Care Med. 2011 Jun 1; 183(11):1447-8. PMID: 21642254.
    View in: PubMed
  5. Martin Joyce-BradyJun Hiratake . Inhibiting Glutathione Metabolism in Lung Lining Fluid as a Strategy to Augment Antioxidant Defense. Current Enzyme Inhibition. 2011; 7(2):71-78.
    View in: External Website
  6. Martin Joyce-Brady, William W Cruikshank, Susan R. Doctrow. Antioxidant Strategies in the Treatment of Bronchial Asthma. Bronchial Asthma-Emerging Therapeutic Strategies (Dr. Liz Sapey, Ed). 2011.
    View in: External Website
  7. Klings ES, Lowry MH, Li G, Jean JC, Fernandez BO, Garcia-Saura MF, Feelisch M, Joyce-Brady M. Hyperoxia-induced lung injury in gamma-glutamyl transferase deficiency is associated with alterations in nitrosative and nitrative stress. Am J Pathol. 2009 Dec; 175(6):2309-18. PMID: 19850887.
    View in: PubMed
  8. Walkey AJ, Reardon CC, Sulis CA, Nace RN, Joyce-Brady M. Epidemiology of ventilator-associated pneumonia in a long-term acute care hospital. Infect Control Hosp Epidemiol. 2009 Apr; 30(4):319-24. PMID: 19245314.
    View in: PubMed
  9. Martin Joyce-Brady, JC Jean, RE Marc, Lou Ann S Brown. Lung Lining Fluid Glutathione in Antioxidant Defense and Cysteine Supply. Research Advances in Respiratory Cell & Molecular Biology. Global Research Network. Karala. 2009; (1):1-18.
  10. Jean JC, Lü J, Joyce-Brady M, Cardoso WV. Regulation of Fgf10 gene expression in murine mesenchymal cells. J Cell Biochem. 2008 Apr 15; 103(6):1886-94. PMID: 18022820.
    View in: PubMed
  11. Lowry MH, McAllister BP, Jean JC, Brown LA, Hughey RP, Cruikshank WW, Amar S, Lucey EC, Braun K, Johnson P, Wight TN, Joyce-Brady M. Lung lining fluid glutathione attenuates IL-13-induced asthma. Am J Respir Cell Mol Biol. 2008 May; 38(5):509-16. PMID: 18063838.
    View in: PubMed
  12. Kuang PP, Joyce-Brady M, Zhang XH, Jean JC, Goldstein RH. Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-beta and phosphatidylinositol 3-kinase activity. Am J Physiol Cell Physiol. 2006 Dec; 291(6):C1412-21. PMID: 16837650.
    View in: PubMed
  13. Jean JC, Rich CB, Joyce-Brady M. Hypoxia results in an HIF-1-dependent induction of brain-specific aldolase C in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L950-6. PMID: 16798780.
    View in: PubMed
  14. Little FF, Joyce-Brady M. "Trends in Nebulizer Therapy". Business Briefing: US Respiratory Care 2006, London, touch Briefings. 2005; 98-100.
  15. Joyce-Brady M, Little FF. Asthma Triggered by Viral Infections: A persistent problem. Advance for Managers of Respiratory Care 14. 2005; 44-46.
  16. Hendra KP, Bonis PA, Joyce-Brady M. Development and prospective validation of a model for predicting weaning in chronic ventilator dependent patients. BMC Pulm Med. 2003 Nov 13; 3:3. PMID: 14614783.
    View in: PubMed
  17. O'Regan AW, Joyce-Brady M. "Pond poop" from propofol. Intensive Care Med. 2003 Nov; 29(11):2106. PMID: 14551681.
    View in: PubMed
  18. Kuang PP, Goldstein RH, Liu Y, Rishikof DC, Jean JC, Joyce-Brady M. Coordinate expression of fibulin-5/DANCE and elastin during lung injury repair. Am J Physiol Lung Cell Mol Physiol. 2003 Nov; 285(5):L1147-52. PMID: 12909585.
    View in: PubMed
  19. Jean JC, Liu Y, Joyce-Brady M. The importance of gamma-glutamyl transferase in lung glutathione homeostasis and antioxidant defense. Biofactors. 2003; 17(1-4):161-73. PMID: 12897438.
    View in: PubMed
  20. O'Regan AW, Castro C, Lukehart SA, Kasznica JM, Rice PA, Joyce-Brady MF. Barking up the wrong tree? Use of polymerase chain reaction to diagnose syphilitic aortitis. Thorax. 2002 Oct; 57(10):917-8. PMID: 12324682.
    View in: PubMed
  21. Jean JC, Liu Y, Brown LA, Marc RE, Klings E, Joyce-Brady M. Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxia. Am J Physiol Lung Cell Mol Physiol. 2002 Oct; 283(4):L766-76. PMID: 12225953.
    View in: PubMed
  22. Joyce-Brady M, Liu Y, Marc RE, Jean JC. “The Importance of Gamma-Glutamyl Transferase in Lung Glutathione Homeostasis and Antioxidant Defense,”. In: Thiol Metabolism and Redox Regulation of Cellular Functions. A Pompella, G Banhegyi and M Wellman-Rousseau (Eds). NATO Science Series, IOS Press. Amsterdam, Netherlands. 2002.
  23. Jean JC, Eruchalu I, Cao YX, Joyce-Brady M. DANCE in developing and injured lung. Am J Physiol Lung Cell Mol Physiol. 2002 Jan; 282(1):L75-82. PMID: 11741818.
    View in: PubMed
  24. O'Regan A, Joyce-Brady M. Latent tuberculosis may persist for over 40 years. BMJ. 2001 Sep 15; 323(7313):635. PMID: 11557726.
    View in: PubMed
  25. Joyce-Brady M, Jean JC, Hughey RP. gamma -glutamyltransferase and its isoform mediate an endoplasmic reticulum stress response. J Biol Chem. 2001 Mar 23; 276(12):9468-77. PMID: 11116135.
    View in: PubMed
  26. Jean JC, Oakes SM, Joyce-Brady M. The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters. Genomics. 1999 Apr 15; 57(2):201-8. PMID: 10198159.
    View in: PubMed
  27. Jean JC, Harding CO, Oakes SM, Yu Q, Held PK, Joyce-Brady M. gamma-Glutamyl transferase (GGT) deficiency in the GGTenu1 mouse results from a single point mutation that leads to a stop codon in the first coding exon of GGT mRNA. Mutagenesis. 1999 Jan; 14(1):31-6. PMID: 10474818.
    View in: PubMed
  28. Panchenko MP, Joyce-Brady M, Starikova MG, Oakes SM, Adachi R, Brody JS, Dickey BF. Atrial natriuretic peptide modulates alveolar type 2 cell adenylyl and guanylyl cyclases and inhibits surfactant secretion. Biochim Biophys Acta. 1998 May 27; 1403(1):115-25. PMID: 9622608.
    View in: PubMed
  29. Oakes SM, Takahashi Y, Williams MC, Joyce-Brady M. Ontogeny of gamma-glutamyltransferase in the rat lung. Am J Physiol. 1997 Apr; 272(4 Pt 1):L739-44. PMID: 9142949.
    View in: PubMed
  30. Takahashi Y, Oakes SM, Williams MC, Takahashi S, Miura T, Joyce-Brady M. Nitrogen dioxide exposure activates gamma-glutamyl transferase gene expression in rat lung. Toxicol Appl Pharmacol. 1997 Apr; 143(2):388-96. PMID: 9144455.
    View in: PubMed
  31. Powell CA, Joyce-Brady M. “Acute and Chronic Respiratory Failure”. In: A Practical Approach to Pulmonary Medicine. RH Goldstein, JJ O’Connell and JB Karlinsky (Eds). Lippincott-Raven Publishers. Philadelphia, PA. 1997.
  32. Joyce-Brady M, Oakes SM, Wuthrich D, Laperche Y. Three alternative promoters of the rat gamma-glutamyl transferase gene are active in developing lung and are differentially regulated by oxygen after birth. J Clin Invest. 1996 Apr 1; 97(7):1774-9. PMID: 8601644.
    View in: PubMed
  33. Cardoso WV, Williams MC, Mitsialis SA, Joyce-Brady M, Rishi AK, Brody JS. Retinoic acid induces changes in the pattern of airway branching and alters epithelial cell differentiation in the developing lung in vitro. Am J Respir Cell Mol Biol. 1995 May; 12(5):464-76. PMID: 7742011.
    View in: PubMed
  34. Rishi AK, Joyce-Brady M, Fisher J, Dobbs LG, Floros J, VanderSpek J, Brody JS, Williams MC. Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives. Dev Biol. 1995 Jan; 167(1):294-306. PMID: 7851650.
    View in: PubMed
  35. Joyce-Brady M, Takahashi Y, Oakes SM, Rishi AK, Levine RA, Kinlough CL, Hughey RP. Synthesis and release of amphipathic gamma-glutamyl transferase by the pulmonary alveolar type 2 cell. Its redistribution throughout the gas exchange portion of the lung indicates a new role for surfactant. J Biol Chem. 1994 May 13; 269(19):14219-26. PMID: 7910609.
    View in: PubMed
  36. Martin Joyce-Brady. Correspondence: The Search for Mycobacterial DNA in Granulomatous Tissues from Patients with Sarcoidosis Using the Polymerase Chain Reaction: Reply. American Review of Respiratory Disease. 1993; 147(3):777.
  37. Joyce-Brady M. "Tastes great, less filling". The debate about mycobacteria and sarcoidosis. Am Rev Respir Dis. 1992 May; 145(5):986-7. PMID: 1586076.
    View in: PubMed
  38. Steele MP, Levine RA, Joyce-Brady M, Brody JS. A rat alveolar type II cell line developed by adenovirus 12SE1A gene transfer. Am J Respir Cell Mol Biol. 1992 Jan; 6(1):50-6. PMID: 1728294.
    View in: PubMed
  39. Joyce-Brady M, Rubins JB, Panchenko MP, Bernardo J, Steele MP, Kolm L, Simons ER, Dickey BF. Mechanisms of mastoparan-stimulated surfactant secretion from isolated pulmonary alveolar type 2 cells. J Biol Chem. 1991 Apr 15; 266(11):6859-65. PMID: 1849893.
    View in: PubMed
  40. Brody JS, Joyce-Brady M, Steele MP. “Growth and Differentiation of Pulmonary Alveolar Epithelial Cells,”. In: Respiratory Epithelium. P. Nettesheim, DG Thomassen (Eds). Academic Press. 1991; 60-66.
  41. Paine R, Joyce-Brady M, Clement A, Brody JS. Serum accelerates the loss of type II cell differentiation in vitro. Am J Respir Cell Mol Biol. 1990 Oct; 3(4):311-23. PMID: 1698400.
    View in: PubMed
  42. Joyce-Brady MF, Brody JS. Ontogeny of pulmonary alveolar epithelial markers of differentiation. Dev Biol. 1990 Feb; 137(2):331-48. PMID: 2303166.
    View in: PubMed
  43. Brody JS, Joyce-Brady M. Alveolar cell differentiation markers in human lungs. J Mol Cell Cardiol. 1989 Feb; 21 Suppl 1:161-4. PMID: 2733026.
    View in: PubMed
  44. Joyce-Brady MF. "Diseases of the Pleura,". In: Clinical Problems in Acute Care Medicine. Heffernan JJ, Witzburg RA, and Cohen AS (Eds). W.B. Saunders Company. Philadelphia, PA. 1989.
  45. Joyce-Brady MF. "Tuberculosis,". In: Clinical Problems in Acute Care Medicine. Heffernan JJ, Witzburg RA, and Cohen AS (Eds). W.B. Saunders Company. Philadelphia, PA. 1989.
  46. Joyce-Brady MF. "Adult Respiratory Distress Syndrome,". In: Clinical Problems in Acute Care Medicine. Heffernan JJ, Witzburg RA, and Cohen AS (Eds). W.B. Saunders Company. Philadelphia, PA. 1989.
  47. Joyce-Brady MF. "Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease,". In: Clinical Problems in Acute Care Medicine. Heffernan JJ, Witzburg RA, and Cohen AS (Eds). W.B. Saunders Company. Philadelphia, PA,. 1989.
  48. Brody JS, Vaccaro CA, Joyce-Brady MF. Human pulmonary alveolar type 2 cells contain an apical membrane glycoprotein common to malignant cells. Lab Invest. 1988 Oct; 59(4):522-30. PMID: 3172711.
    View in: PubMed
  49. Marshall BC, Joyce-Brady MF, Brody JS. Identification and characterization of the pulmonary alveolar type II cell Maclura pomifera agglutinin-binding membrane glycoprotein. Biochim Biophys Acta. 1988 Sep 8; 966(3):403-13. PMID: 3416017.
    View in: PubMed
  50. Brody JS, Joyce-Brady M, Paine R. Lung cell differentiation. Mead Johnson Symp Perinat Dev Med. 1987; (30):39-42. PMID: 3333417.
    View in: PubMed
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